Acrokeratosis verruciformis of Hopf

F. Peral Rubio, M.D.Department of DermatologyHospital Universitario Virgen MacarenaSeville, Spain

Acrokeratosis verruciformis of Hopf

A 60 -years-old woman.The patient was referred to us for

the assessment of lesions on the hands 20 years previously.

symmetrical lesions

skin-colored, wart-like lesions

punctate keratoses

Acrokeratosis verruciformis of Hopf Skin biopsy was performed and

histological examination showed:• Mild acanthosis with slight papillomatosis.

• There was also hyperkeratosis, most marked at the edges of the lesion, with moderate hypergranulosis and a thin layer of orthokeratosis.

• The dermis was infiltrated with a few inflammatory cells surrounding the vessels

Acrokeratosis verruciformis of Hopf

Acrokeratosis verruciformis of Hopf is an autosomal dominant genodermatosis.

It is characterized by multiple, localized, symmetrical, flat, skin-colored, wart-like lesions, typically observed on the dorsum of the hands and feet

Acrokeratosis verruciformis of Hopf

Lesions are usually present at birth, but they may appear later in infancy or in some cases, onset may be delayed until the fifth decade of life.

Apart from the typical skin-colored, flat, warty papules, examination may reveal thickening of palmar skin and punctate keratoses on the palms and the soles.

Acrokeratosis verruciformis of Hopf

F. Peral Rubio, M.D.Department of DermatologyHospital Universitario Virgen MacarenaSeville, Spain