achieving a complexion blemish-free -...

Innovation you can build on™

Achieving a Blemish-Free

Complexion

Jennifer Donahue Marketing Manager

Abhijit Bidaye Applications Team Leader

Blem

ish-Free Com

plexion


#1skin condition in the US

Statistics (American Academy of Dermatology)

“Acne is the most common skin disorder in the

United States, affecting 40-50 million Americans.”

Nearly 85% of all people have acne at some point

in their lives, most often on the face, chest, and

back.

By mid-teens, more that 40% of adolescents have

acne or acne scarring, which requires treatment

by a dermatologist.

More than 50% of women age 25-58 report

suffering from some sort of acne

Acne effects all age groups and both genders

www.aad.org


Acne Presenta

tion Global acne market worth $3.5 billion

The USA accounts for 37% of global market

Largest growth seen in Mexico, Brazil and

South Korea

Source: Euromonitor Feb 2015


Acne Presenta

tion US skin care market– 2014 mass market

Acne is #3 in

both sales $

and volume!

Sub-Category

Kilo

Share

2014

Kilo

% chg

vs PY

FACE CARE -1%

ACNE 45% -1%

CLEANSERS 31% 0%

MOISTURIZERS 16% 0%

ANTI-AGERS 6% -4%

TONERS 2% -1%

Category

worth $852 45% of Facial

products

claim Acne

Source: Neilsen Feb 2015


Acne Presenta

tion Product launch activity

385

Source: GNPD Feb 2015



Complexion

Discovering Consumer

Needs

Blem

ish-Free Com

plexion


Consumer research

Focus Group

Consumer panelists all had mild to moderate acne and used

one or more products daily to care for their acne. Panelists

also conducted an at home use study of Croda’s Clear &

Smooth prototypes.

Group 1: Adults

8 Men and Women, ages 20-32

Group 2: Teens

Group of 6 girls ages 14-17

Group of 4 boys ages 14-17 with their mothers (to gain

insight into purchasing decisions)

Group 3: Dermatologists

3 NJ/NY practicing dermatologists

Blem

ish-Free Com

plexion


Key learnings

1. Product usage fits consumers lifestyle & vary

2. Treatments that are considered harsh are not

used as directed

3. Product loyalty is low

Switching products perceived to help achieve

better performance

Dermatologists agree

4. High emotional impact of having a ‘bad skin

day’ due to acne

“I get bored with stuff so I switch it up.”

“You need to switch up your products

over time. Your body builds up a

resistance to it so it doesn’t work as

well.”


Acne Presenta

tion How acne makes consumers feel

Good Day

“You don’t focus on your

acne.”

“You don’t think about it.”

“It is one less thing you need

to worry about.”

“You feel better, more self

confident.”

“You look in the mirror and you

are happier.”

Bad Day

“Feel like no one is giving you eye contact just

staring at your pimple.”

“Stay inside more or make excuses not to go

out.”

“Reluctant to get into pictures.”

“Photoshop pictures you are in to remove

acne.”

“ I avoid selfies”

“You can feel the pressure and want to pop it.”

“You look bad so you don’t bother to try. You

wear sweat pants.”

“You try to cover it up.”

“Pile-on concealer”


Acne Presenta

tion

Facebook

Strengthen your self-

esteem with Asepxia

March 2014

Facebook

Check out our

new line of

products

September 2014

Appealing to consumer emotions

es-la.Facebook.com/asepxia

es-la.Facebook.com/asepxia

Blem

ish-Free Com

plexion


What do consumers want? Non-Drying products

“Acne cream that doesn’t dry or age my skin”

Targeted products

“A body wash to eliminate body acne for exercise”

Quicker performance

“Put on a pimple at night and acne is gone in the

morning”

Products that don’t cause skin to break out

“A face cream that won’t cause breakouts”

Good skin tone & color

“I want a product that gives me perfectly clear skin,

with good skin tone that will balance out the color”

Blem

ish-Free Com

plexion


Consumers want improved skin texture

Softer skin

“I would wish for skin of a newborn baby”

“To clear my face and neck for life with smoother,

softer skin.”

Less noticeable pores

“A face product that minimizes pore size”

“Make my skin look flawless with no bumps or

acne”

Blem

ish-Free Com

plexion


Audience Poll 1

What do you think are the biggest unmet needs

in the acne market?

(choose as many as apply)

Formulations that are less irritating to skin

New ways to exfoliate

Formulations that deliver quicker results

More convenient formats

Multifunctional products (moisturize, cleanser,

and spot treatment in one)



Complexion

Technology to Address Consumer

Needs



Complexion

Clear & Smooth 3-

Step System

Blem

ish-Free Com

plexion


3-step regimen: Clinical study

Modelled after a market leading brand, Croda

developed 3 products that are recommended

for use both AM and PM

Clear & Smooth Scrub SC-629

Clear & Smooth Treatment SC-630

Clear & Smooth Hydrator SC-631

Tested at AMA labs (New City, NY) for 28 days

against a market leading brand

10 female panelists ages 19-28

Mild to moderate facial acne (Grade 2-3)

Evaluations at Day 7, 14, 21, & 28


Acne Presenta

tion Achieve results one week faster!

-14.6%

-25.6%

-37.2%

-51.8%

-6.1%

-14.4%

-23.5%

-37.9%

-60%

-50%

-40%

-30%

-20%

-10%

0%

Percent (%) Reduction

Total Reduction in Acne Lesions

Croda Regimen Market Leading Brand

Day 7 Day 14 Day 21 Day 28

23.4 24.8 20.4 22.6 17.2 20.2 13.2 16.4

Speed

(consumer want)

3 weeks vs 4 Efficacy

52% vs 38% less

acne lesions


Acne Presenta

tion

“It makes me feel like I

am really cleansing my

skin.”

“I like the fact that it is

a cream cleanser

(gentle on my skin).”

Clear & Smooth Scrub Ingredients Function %

Part A

Deionized Water 58.42

Acrylates/C10-30 Alkyl Acrylate Crosspolymer Rheology Modifier 0.60

Glycerin Humectant 3.00

Part B

Sodium Cocoyl Isethionate Cleansing Agent 15.00

Part C

ARLASILK™ PTS (Stearamidopropyl PG-dimonium

Chloride Phosphate and Cetyl Alcohol)

Moisturizer,

Emulsifier 1.50

CRODAFOS™ BES-70 (Beheneth-30 Phosphate

(and) Cetyl Phosphate (and) Cetearyl Alcohol) Emulsifier 1.80

CRODACOL S95 (Cetyl Alcohol) Bodifying Agent 3.00

PRISORINE 3515 (Isostearyl Alcohol) Emollient 3.00

Squalane Moisturizer 1.50

Part D


Sodium Hydroxide, 50% Neutralizing Agent 0.35

Part E

ARLASOLVE™ DMI (Dimethyl Isosorbide)

Solublizer, Active

Delivery 5.00

Benzoyl Peroxide, 75% Active Anti-acne Active 3.33

Part F

Ethylhexylglycerin (and) Caprylyl Glycol Preservative 0.10

Fragrance 0.40

Polyethylene Exfoliator 2.00

SC-629


Acne Presenta

tion Clear & Smooth Anti-Acne Treatment Ingredients Function %

Part A


Carbomer Rheology Modifier 0.20


Part B

CRODAFOS™ CES (Cetearyl Alcohol (and) Dicetyl

Phosphate (and) Ceteth-10 Phosphate)

Sensory, Stability &

Delivery

5.00

CROPURE™ ALMOND OIL (Prunus Amygdalus

Dulcis (Sweet Almond) Oil)

Nourishing Oil 2.50

ARLAMOL™ LST (PPG-3 Isostearyl Methyl Ether) Sensory, Emollience 5.00

SENSASIL PCA (PCA Dimethicone) Sensory, Emollience 1.00

Part C


Sodium Hydroxide, 50% Neutralization 0.20

Part D

ARLASOLVE™ DMI (Dimethyl Isosorbide) Solubilizer, Delivery 5.00

Benzoyl Peroxide, 75% active Anti-acne Active 3.33

Part E

AC.NET™ (Water (and) Butylene Glycol (and) PEG-

60 Almond Glycerides (and) Caprylyl Glycol (and)

Glycerin (and) Carbomer (and) Nordihydroguaiaretic

Acid (and) Oleanolic Acid)

Holistic treatment

for acne prone skin

or oily skin

3.00


Part F

Fragrance 0.10

“Easy to spread.

My skin felt

softer after using

it.”

SC-630


Acne Presenta

tion

6.49*

9.92*

13.78*

16.82*

0

2

4

6

8

10

12

14

16

18

One Application Three Applications

Commercial Application Croda Application

+112%

+70%

Treat & increase hydration

Net Change in

Hydration

(Arbitrary Units)

*significant p<0.001


Acne Presenta

tion Clear & Smooth Hydrating Cream

Ingredients Function %

Part A

Sodium Hydroxide, 50% Neutralizing Agent 0.28

Water 78.72

Butylene Glycol Humectant 4.00

CHROMOCARE™ (Butylene Glycol (and) Water (and)

Siegesbeckia Orientalis Extract (and) Rabdosia

Rubescens Extract)

Skin Complexion

Improvement 3.00

Part B

ARLASOLVE™ DMI (Dimethyl Isosorbide) Solublizer, Delivery 2.00

Salicylic Acid Anti-acne Active 0.50

Part C

SP CRODAMOL™ GTCC MBAL (Caprylic/Capric

Triglyceride)

Non-comedeogenic

Emollient 3.00

Polydiethylsiloxane Emollient 3.00


Part D

VISCARESS™ HPD (Polyquaternium-37 (and)

Hydrogenated Polydecene (and) Trideceth-6) Sensory & Stability 5.00

“Very soft, and easy to spread”

SC-631


Acne Presenta

tion Technologies for enhanced efficacy

ARLASOLVE™ DMI

Spot on actives delivery

Reduces irritation of BPO

Increases efficacy of actives

Wide ingredient compatibility ARLASOLVE™ DMI

AC.NET™

AC.NET™

Fights “break-outs”

A holistic approach to treating oily and acne prone skin

Fights against local inflammation & bacteria proliferation

Helps reduce clogging of pores due to hyperkeratosis

CHROMOCARE™

CHROMOCARE™

Evens the complexion

Prevent and control the discolorations due to blemishes

Improves skin uniformity and luminosity for a fresh look

Fights oxidative stress to reduce red and brown spots


Acne Presenta

tion Can BPO be efficacious from a cleanser?

• BPO is highly effective at limiting P. acnes and other

bacteria from leave-on systems

• However, BPO cleansers show limited antibacterial

action from rinse off cleansing systems unless very

high levels of BPO are used*

• Arlasolve DMI substantially boosts the efficacy of BPO

from cleansers with much shorter cleansing times than

BPO alone

* Source: “What is the Role of Benzoyl Peroxide Cleansers in Acne Management?”

James Q. Del Rosso, Journal of Clinical Aesthetic Dermatology


Acne Presenta

tion

0%

20%

40%

60%

80%

100%

T0 T300 secs - 4.5% BPOalone

T300 secs - 8.5% BPOalone

T300 secs - 4.0% BPOw/ ARLASOLVE DMI

% o

f B

ac

teri

a C

olo

nie

s R

em

ain

ing

(colo

ny-f

orm

ing u

nits/g

ram

) Can BPO be efficacious from a cleanser?

Antibacterial Efficacy Study of BPO Cleansers Cleansers with different levels of BPO with and without Arlasolve DMI

were applied at varying contact times (20 seconds, 1 minute, 5 minutes).

After rinsing, amount of remaining bacterial colonies were assessed.


Acne Presenta

tion

0%

20%

40%

60%

80%

100%




% o

f B

ac

teri

a C

olo

nie

s R

em

ain

ing

(colo

ny-f

orm

ing u

nits/g

ram





-5%

T 5 min

4.5% BPO alone

4.5% BPO alone, after minutes,

offers little reduction of bacteria


Acne Presenta

tion

0%

20%

40%

60%

80%

100%




% o

f B

ac

teri

a C

olo

nie

s R

em

ain

ing

(colo

ny-f

orm

ing u

nits/g

ram





-40%

T 5 min

4.5% BPO alone

T 5 min

8.5% BPO alone

Even double the BPO (8.5%) only

reduces bacterial growth by 40%


Acne Presenta

tion

0%

20%

40%

60%

80%

100%




% o

f B

ac

teri

a C

olo

nie

s R

em

ain

ing

(colo

ny-f

orm

ing u

nits/g

ram

) Kill bacteria fast, even in cleansers

Antibacterial Efficacy Study of BPO Cleansers Cleansers with different levels of BPO with and without ARLASOLVE DMI



T 5 min

4.5% BPO alone

T 5 min

8.5% BPO alone

99%

Boosting action of ARLSOLVE DMI

delivers better antibacterial action in seconds

with half the level of BPO than BPO alone

delivers in minutes

T 20secs

4.0% BPO w/ DMI


Acne Presenta

tion How it works

DMI ensures BPO has maximum contact time with the pore and the P.acnes (acne-

causing) bacteria

Arlasolve™ DMI INCI: Dimethyl Isosorbide

Dissolved BPO does not equal delivered BPO

If BPO is only dissolved, it will remain on the skin’s surface and

contribute to irritation

Leading Brand with ARLASOLVE DMI Leading Brand without ARLASOLVE DMI

Polarized, quarter-wave plate; 400x magnification


Acne Presenta

tion Prevent breakouts

with AC.NET™: an association of 3

ingredients designed to tackle the problem

of oily & acne-prone skin on all fronts

20 volunteers with oily, combination skin prone to acne/Twice daily

application of a gel containing 3% ac.net™ for 8 weeks.

DECREASE IN THE NUMBER OF LESIONS

Retentional lesions………...-35%/D56

Inflammatory lesions………-32%/D56


Acne Presenta

tion with CHROMOCARE™

Improves skin uniformity and luminosity, in order to

provide a fresh looking skin.

Fights against oxidative stress – a main cause of skin

damage (collagen degradation, inflammation, red and

brown spots).

Blemishes contribute to spots on the skin;

Chromocare can help prevent and control the

discolorations due to blemishes

Even skin tone


Acne Presenta

tion Technologies for enhanced sensory

ARLASILK™ PTS

Biomimetic Skin Conditioner

Non-occlusive moisturizer

Effective skin conditioner in body cleansers

Silky smooth after-feel

CRODAFOS™ BES-70

Building Exceptional Sensory

Provides excellent pH tolerance

Naturally substantive to skin

Behenyl chemistry provides smooth skin feel

CRODAFOS™ BES-70

ARLAMOL™ LST

ARLAMOL™ LST

Light Silky Touch

Sensory driven emollient

Super fluid that improves formulation aesthetics

Reduce the tackiness

ARLASILK™ PTS


Acne Presenta

tion Create a soft conditioned feel

High actives level gives formulation flexibility

Broad pH tolerance allows for elegant DHA or

Sal Acid formulations

Behenyl based chemistry creates

a rich sensory experience

Steric and charge stabilized

with CRODAFOS™ BES-70 INCI: Beheneth-30 Phosphate (and) Cetostearyl Alcohol (and) Dicetyl Phosphate (and)

Cetyl Phosphate


Acne Presenta

tion Light, silky application with ARLAMOL™ LST INCI: PPG-3 Isostearyl Methyl Ether

Methyl ether capped isostearic alcohol

Ether technology allows for pH stability from pH 4-12

High skin migration value (1205mm2) allows for easy

application

Other properties:

Clear Liquid

Refractve Index (RI) = 1.4459

Required HLB = 12

60% Natural


Acne Presenta

tion

Designed to provide moisturization through polar lipid replacement

Provides long-lasting skin smoothing characteristics in a broad

array of skin care, dermatological and personal care preparations

Imparts a high degree of elegance in skin treatment products in that

it is an excellent emollient that is non-occlusive and adds to

stabilization of emulsions

Moisturize & smooth with ARLASILK™ PTS INCI: Stearamidopropyl PG-dimonium Chloride Phosphate (and) Cetyl Alcohol

Blem

ish-Free Com

plexion


Audience Poll 2

What product form do you think is most needed

by consumers suffering from acne?

Toners

Cleansers

Cover-ups

Treatments

Moisturizers



Complexion

Complete your Care

Blem

ish-Free Com

plexion


Product forms consumers need

Toners for a quick cleanse

Putting your best face forward everyday

Cover-up for the occasional break-out

Be selfie-ready at all times!

“Switch-it up” product

Give your skin a gentle & natural break without

compromising efficacy


Acne Presenta

tion

“I don’t have

time in the

morning- use a

toner…”

Daily Renewal Sensitive Skin Toner SC-655


Part A


Butylene Glycol 1.00

ARLASILK PLN (Linoleamidopropyl PG-Dimonium Chloride

Phosphate Dimethicone (and) Water)

Emollient 1.50

SYNPERONIC 13/12 (Trideceth-12) Wetting agent 1.00

PHYTESSENCE™ PINK POMELO EC (Glycerin (and) Water

(and) Citrus Paradisi (Grapefruit) Fruit Extract)

Natural Exfoliator 3.00

Water (and) Sodium Benzoate (and) Potassium Sorbate Preservative 1.00


Acne Presenta

tion Blemish Cover-Up


Part A


Potassium Hydroxide (10% aq soln.) Neutralizer 1.30

Polysorbate 80 Emulsifier 0.10

Part B

Titanium Dioxide Pigment 7.00

Talc Filler 3.14

Iron Oxide Blend Pigment 1.89

Part C

Propylene Glycol Emulsion stabilizer 4.00

Magnesium Aluminum Silicate Emulsion stabilizer 1.00

Part D

Propylene Glycol Emulsion stabilizer 2.00

Sodium Carboxymethylcellulose Emulsion stabilizer 0.12

Part E

CROMOLLIENT™ DP3-A (Di-PPG-3 Myristyl Ether Adipate) Pigment dispersant 12.00

ARLAMOL™ LST (PPG-3 Isostearyl Methyl Ether) Emollient 4.00

CRODAFOS™ CS20A (Cetearyl Alcohol (and) Ceteth-20 Phosphate

(and) Dicetyl Phosphate)

Emulsifier 3.00

BRIJ™ S10 (Steareth-10) Emulsifier 2.00

CRODACOL™ C70 (Cetyl Alcohol) Structurant 0.62

BRIJ S2 (Steareth-2) Emulsifier 0.50

DERMAXYL™ (C12-15 Alkyl Benzoate – Tribehenin (and) Ceramide

NG (and) PEG 10 Phytosterol (and) Palmitoyl Hexapeptide-12)

Skin active 2.00

Part F

EVERMAT™ (Butylene Glycol (and) Enantia Chlorantha Bark Extract

(and) Oleanolic Acid)

Shine reducer & pore

tightener

3.00

Phenoxyethanol (and) Ethylhexylglycerin Preservative 1.00

MU-105

Keep the

attention on you-

not your acne.


Acne Presenta

tion

Give your skin a

natural break

while keeping your

blemishes under

control

Anti-Blemish Soothing Light Emulsion SC-662


Part A


Carbomer Thickener 0.45


Part B

CRODAMOL™ SSA (Decyl Isostearate (and) Isostearyl

Isostearate) Emollient 3.00

CRODAMOL™ AB (C12-15 Alkyl Benzoate) Emollient 2.00

Acrylates/C10-30 Alkyl Acrylate Crosspolymer Thickener 0.20

Part C


Sodium Hydroxide 50% 0.12

Part D


SEBULESS™ (Maltodextrin (and) Synringa Vulgaris (Lilac) Extract)

Promotes clear

skin 0.50 Part G

TWEEN 20 (Polysorbate 20) Solublizer 1.00


Acne Presenta

tion Technologies for improved complexion

Phytessence™ Pink Pomelo EC

Skin sparkling with life

Organic exfoliator, safe for sensitive skin

Takes days off of the cell turnover cycle

Offers mild exfoliation with no irritation

EVERMAT™

Complexion without a complex

Significantly reduce skin shine

Visibly reduce pore size

Control oily skin EVERMAT™

Phytessence™ Pink

Pomelo EC

SEBULESS™

SEBULESS™

Reduces oiliness and blemishes

Visibly reduces appearance inflammatory blemishes

Limits cellular build up and bacterial anchorage

Regulates sebum production


Acne Presenta

tion with EVERMAT™

Controls oily skin by regulating sebocyte differentiation

and proliferation

Reduces sebum production

Inhibition of 5α reductase

Refines skin grain & reduces appearance of pores

Tighten pores & reduce shine

BEFORE AFTER

3D images of skin

pores

BEFORE AFTER


Acne Presenta

tion with Phytessence™ Pink Pomelo EC INCI: Glycerin (and) Water (and) Citrus Paradisi (Grapefruit) Extract

Organic exfoliator, safe for sensitive skin:

A gentle and effective natural exfoliator

Suitable for daily use

Non-irritating, even for sensitive skin users

(assessed by 48 hr patch test)

Visible benefit for 87% of panelists

Gentle cell turnover


Acne Presenta

tion with SEBULESS™ INCI: Maltodextrin (and) Syringa Vulgaris (Lilac) Extract

Fights multiple mechanisms leading to oily skin and

inflammatory blemishes:

Reduces blemishes by half in one month

Limits cellular build-up

Fights bacterial anchorage

Boosts skin’s natural microbial defense

Regulates sebum production

Natural blemish control

SEBULESS™ 0.5% T0 T1 month

-38%, p<0.01

Significance vs placebo: p<0.01

Red Spot Reduction Evaluation

T0 T1 month

-48%, p<0.05

Significance vs placebo: p<0.01

Inflammatory Blemish Clinical Evaluation

SEBULESS™ 0.5%


Acne Presenta

tion Achieve a blemish-free complexion

Spot on Actives Delivery

Arlasolve DMI

Fights “Break out”

Ac.net

Even complexion

Chromocare

Complexion without a Complex

Evermat

Skin Sparkling with Life

Phytessence Pink Pomelo EC

Reduces Oiliness & Blemishes

Sebuless

Building Exceptional Sensory

Crodafos BES-70

Light Silky Touch

Arlamol LST

Biomimetic Skin Conditioner

Arlasilk PTS

Enhanced Efficacy Improved Complexion Enhanced Sensory

Click to Order

Samples

Clear & Smooth Scrub

SC-629

Clear & Smooth Treatment

SC-630

Clear & Smooth Hydrator

SC-631

Anti-Blemish Soothing Emulsion

SC-662

Blemish Cover-Up

MU-105

Daily Renewal Sensitive Skin Toner

SC-655

Clear & Smooth Regimen Companion Products

http://www.croda.com/samplerequest.aspx?eventID=126dbd84-fe3c-47f1-85f4-0cecfe6e4e09&lid=22818



Acne Presenta

tion Additional Information

Click to Order

Samples

To order free samples, click here.

To contact us, email [email protected]

Links to the presentation slides and the event

recording will be emailed to all attendees.

Thank you for attending!

Recordings of past events and information

about upcoming events are listed on our

website here.




mailto:[email protected]



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