J F 1 A - 3

Sex Age EF ‘% Etiology NYHA

MF s 70 >70 <30 ? 30 CHD no CHD 1-11 Ill-w

n. of Dte 1722 621 1699 644 617 1073 975 1368 1590 753ACE:i “h 83 74 83 74 86 81 80 81 82 76P < < < <

C o8 pts with C f a rs I c ac t w A dw e n t e a m l t We a A p m g ya l v e f w a a w ah r A u U A w s lp p w N I t w a bf c

I1 I C C OHU UA ni

E P M aG H B

r a r a ne i (c h f ( c s d 1

d w i o e rI p w a c h d 1

D ea v w s b up rb P a w t A ( = 3p < 0 w a t w a p h C wt A ( 3 p < 0 A 1 h s 6w p A d i o 1 r

0 F d ip t w A ft n T ( o r

ClinicalVariable ACEI RX No ACEI RX p

Aae. veare & SD 74.1 + 11.8 75.6 + 12.1 0.05- ..Male sex, OR 1.34 (95”/6cl, 1.04-1.74) 0.03Ssrumcreatinine, mgldl 1.4 + 0.9 2.0 * 2.0 0.00001Cardiomagaiypresent, OR 1,57 (95% Cl, 1.14-2.14) 0.005LVejectionfractian,% 34.1 + 14.8 42.2 + 14.6 0.00001

In addition, A w p m f a t ar d d n l f a tr a v c c b A ps m p a t c cI p a t w e e fw u d T A a ii p u u e b ad p ra o p f a w r im d d p A ad r q p c E m ic p s s

H1 V FP C

S cC oT D M SG D M P M aG H B

V ey v r m mp w s h f T v r d

v r f p w < 3 ed ( w p p ( a ( m

V d S e f 9 p m eo i a c m t aerved ae controle( C e nv ( e v ( ms pw m a c ( m r g( d iw q c <

V cl C

f 2 +~ 198 +73 171 +55 175+26 159 *3I

EF (%) 23+ 7 26+ 9 23&3 23&5

Mass (g) 334*87 305+76 306+73 317 *42MR (1+) 2.8+ 1.1 2.5+ 1.4 2.3+ 1,1 2.9 + 0,6”

An increase of > 5% in EF (+ responee)was obaavad in 40% of the patientsafterV andnone in C.

c V – response V + reapanee

LVEF 1 23i 3 25+ 5 19*7LVEF 2 23& 5 23& 6 32+ 11**A LVEF (%) O*5 –2 +4 13+ 6***RVAC 1 46& 14 39+ 17 24& 14*RVAC 2 33+ 18 24+ 10+ 52+ 6**A RVAC (%) –13+ 18 -15 *14 28+ 11***

+P -=0.02 w+1, *P <0.02 Vs < Vs 1, * < Vs c

i o p p + ri < i r w a s a ef 8 s c h f v i vr a i b p p w

m i f

I1 0TheimpsctofWatiarino CiinicaiOutcome~in

E P E J M G H BU B R I C

u i w o f hh f ( f 1 c h e

6 m a d t d h r ft s d p w c dc 2 r h r r 4p d r 1 w gt y a l d l a s ca h h l e f h pa f c v a m

v d d p a Ow e w a d bg c e r a o r d ar a w w a s

Endpaint Warfarin No Werf Odds Ratia PA1l-cauaemartality 17.5”A 18,1% 0.780 0.44Any rehospitalization 48.8% 44.s% 1.274 0.36CHF rehospitalization 32.5”A 23,1”h 1.670 0.07Death or rehospitalization 53,2°h 50.3% 1.142 0.62

The d r d b g @ = 0 Ma q l m i f c m ad = 0 o c f p 0w w w g O t f rp f w g 0 T l

s s s c m t ss t 6 e r o c op w w t C r c la c p w fd c l p r t

E MC

W S G A SU H G S 1A H MS

M & i m f a l ap w c h f s h a d

l c m p s a c en p M I D C

( t P M p ( 1m 1 M g a d a

A ( d ( f ( N c I( N c ( N c ( N c (w a f e m T w r

c m P V M 0 a np h t ( P 2 M < 0

C c w b a c h c S1 C i p e m

f a H M c a a e rp h a t M o c mi n v p R T c

p 1 v = a = n