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AaronMichaelMohs,Ph.D.DepartmentofPharmaceuticalSciencesFred&PamelaBuffettCancerCenterUniversityofNebraskaMedicalCenter986858NebraskaMedicalCenterOmaha,NE68198-6858EDUCATIONAug.2002–Dec.2006 DoctorofPhilosophy PharmaceuticsandPharmaceuticalChemistry UniversityofUtah SaltLakeCity,UT Dissertation:BiodegradableMacromolecularContrastAgentsfor

MagneticResonanceImaging.(DefendedSept.28,2006) Mentor:Dr.Zheng-RongLu,Ph.D.

Aug.1998–May2002 BachelorofArts Chemistry(Biologyconcentration) SaintJohn’sUniversity/CollegeofSaintBenedict Collegeville,MN UndergraduateResearch:Bidentatenitrogenousmolybdenum

complexesascatalysts. Mentor:Dr.ChrisSchaller,Ph.D.

POSTDOCTORALTRAININGOct.2006–July2011 PostdoctoralFellowship BiomedicalEngineering EmoryUniversity–GeorgiaInstituteofTechnology Atlanta,GA ResearchEmphasis:NanotechnologyforBiomedicalImaging

Applications Mentor:Dr.ShumingNie,Ph.D.

ACADEMICAPPOINTMENTS2015–Present AssistantProfessor(Tenure-Track),DepartmentofPharmaceuticalSciences,

CollegeofPharmacy,UniversityofNebraskaMedicalCenter

2015–Present CourtesyAssistantProfessor,BiochemistryandMolecularBiology,CollegeofMedicine,UniversityofNebraskaMedicalCenter

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2015–Present Member,TheFredandPamelaBuffettCancerCenter,UniversityofNebraskaMedicalCenter

2015–Present Member,CenterforDrugDeliveryandNanomedicine,UniversityofNebraskaMedicalCenter

2015–2016 AdjunctAssistantProfessor,BiomedicalEngineering,WakeForestUniversityHealthSciences

2011–2015 AssistantProfessor(Tenure-Track),BiomedicalEngineering(primary),CancerBiology(joint),andRegenerativeMedicine(joint),WakeForestUniversityHealthSciences,WakeForestUniversity–VirginiaTechSchoolofBiomedicalEngineeringandSciences(SBES-WFUHS)

CERTIFICATESANDLICENCESNone.

GRANT/CONTRACTSUPPORTCurrentFundingTitle: TunableFluorescentOrganicNanoparticlesforCancerImaging

Applications.FundingAgency: NIH/NCIMechanism: R21CA212500Dates: 02/15/2017–01/31/2020TotalDollars: $602,000($400,000direct)Investigators: PI:Mohs;co-I:Dr.TonyHollingsworth

Title: NonclinicaldevelopmentofNervelight,anintra-operativeperipheralnerveimagingagent.

FundingAgency: NIH/NCIMechanism: R44CA180745Dates: 09/25/2017–08/31/2019TotalDollars: $1,972,209;$509,856toUNMC($336,785direct);contractinprocessInvestigators: sub-PI:Mohs;PI:ManzanitaPharmaceuticals(Dr.StephenKahl)

Title: HyaluronicAcidBasedNanoparticlesforTargetedImage-GuidedTumorSurgery.

FundingAgency: NIH/NIBIBMechanism: R01EB019449Dates: 09/25/2014–06/30/2018TotalDollars: $1,325,018($895,500direct)Investigators: PI:Mohs;co-I:Drs.FrankC.MariniandGracaAlmeida-Poroda

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Title: NanoparticleFormulationsofOrlistatforTreatmentofChemoresistantCancer.

FundingAgency: NIH/NIGMSMechanism: ProjectunderP20GM103480(COBRE:NebraskaCenterfor

Nanomedicine.)Dates: 06/01/2016–05/31/2018TotalDollars: $250,000directInvestigators: ProjectPI:Mohs

Title: PositionstoSupporttheNationalStrategicResearchInstitute.FundingAgency: NebraskaResearchInitiativeDates: 01/01/2016–12/31/2018TotalDollars: $375,550directInvestigators: PI:Mohs

Title: MultimodalContrastAgentsforIntegratedPreoperativeandIntraoperativeImagingofPancreaticCancer.

FundingAgency: Cattlemen'sBallAssociationofNebraskaMechanism: UNMCPancreaticSPOREDevelopmentalResearchProjectDates: 09/01/2016–08/31/2017(continuedunderno-costextension)TotalDollars: $50,000directInvestigators PI:Mohs;co-I:Dr.YutongLiu(formerco-I:Dr.MichaelBoska)

Title: Developmentofcontrastagentstargetingtolymphangiogenesisinanorthotopicprostatecancermodel.

FundingAgency: DepartmentofUrologyviaDaviesPhilanthropyDates: 06/01/2016–05/31/2017(continuedunderno-costextension)TotalDollars: $50,000directInvestigators: PI:Mohs;co-PI:Dr.SamikshanDutta;co-I:Drs.KaustubhDattaandChad

LaGrange

Title: NanomedicineApproachestoImage-GuidedDrugDeliveryinMetastaticCancers.

FundingAgency: UNMCCollegeofPharmacyMechanism SeedGrantFundsDates: 07/01/2017–06/30/2018TotalDollars: $90,000directforallPIscombinedInvestigators: co-PIs:Drs.Mohs,JeredGarrison,DJMurry,andDavidOupicky

CompletedFundingTitle: Nanotechnologyforminimallyinvasiveforcancerdetectionand

resection.FundingAgency: NIH/NCIMechanism: K99/R00PathwaytoIndependenceAwardinCancerNanotechnology

Research;K99/R00CA153916

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Dates: 09/03/2010–03/31/2017TotalDollars: $894,259($654,711direct)K99andR00phasescombinedInvestigators: PI:Mohs

Title: Longitudinalassessmentsofplacentaloxygenationandperfusionusingultrasoundandphotoacoustics.

FundingAgency: NIH/NICHDMechanism: R21HD086357Dates: 09/17/2015–8/31/2017TotalDollars: $45,690($30,359direct)Investigators: PI:Dr.Yamaleyeva(subcontractPI:Mohs)

Title: Multimodalcontrastagentsforpreoperativeandintraoperativeimaging.

FundingAgency: NebraskaDepartmentofHealthandHumanServicesMechanism: LB5062017-41Dates: 07/01/2016–06/30/2017TotalDollars: $50,000Investigators: PI:Mohs

Title: DevelopmentofMultimodalImagingNanoparticlesforIntegratedPreoperativeandIntraoperativeImaging.

FundingAgency: NebraskaCenterforNanomedicineMechanism: ImagingRelatedPilotGrantsDates: 06/01/2015–05/31/2017TotalDollars: $10,000Investigators: PI:Mohs;co-PI:Dr.MichaelBoska

Title: Nanoparticle-BasedDeliveryofNovelFattyAcidSynthaseInhibitors.FundingAgency: WakeForestUniversityHealthSciences&VirginiaTechMechanism: WFUComprehensiveCancerCenter-SchoolofBiomedicalEngineering

andSciencesJointPilotAwardDates: 09/01/2014–08/31/2015TotalDollars: $50,000Investigators: PI:Dr.StevenKridel;co-PI:Mohs,Dr.ToddLowther

Title: OpticalMolecularTomographyforRegenerativeMedicine.FundingAgency: NIH/NHLBIMechanism: BioengineeringResearchPartnership;R01HL098912Dates: 03/01/2010–11/30/2014TotalDollars: $2,852,790Investigators: PI:Dr.GeWang;co-PI:Dr.ShaySoker;co-I:Mohs,Dr.YongXu,etal.

Title: ControlledReleaseBiomaterialsforIL-35SecretingMesenchymalStromalCellsfortheTreatmentofTypeIDiabetes.

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FundingAgency: WakeForestInstituteforRegenerativeMedicineMechanism: PromotingInnovativeDiscoveriesPilotDates: 08/01/2014–07/31/2015(approximate)TotalDollars: $25,000Investigators: PI:Mohs;co-PIs:Drs.EmmanuelOpara,ChrisPorada,GracaAlmeida-

Porada

Title: NewNearInfraredImagingMethodtoDetectGeneticallyLabeledCellsUsingaNerve/MuscleConstructModel.

FundingAgency: WakeForestInstituteforRegenerativeMedicine Mechanism: PilotSeedGrantDates: 06/01/2012–05/31/2013(approximate)TotalDollars: $25,000Investigators: PI:Mohs;co-PIs:Drs.KhalilBitar,FrankMarini,RobertGilmont

STUDYSECTIONSNational/International

2017 AdhocMember,MedicalImagingStudySection(MEDI),NIHCenterforScientificReview,Denver,CO

2015 Member,SpecialEmphasisPanel(2015/05ZCA1TCRB-Q(M1)),CentersforCancerNanotechnologyExcellence(CCNE),Bethesda,MD

2015 Reviewer,AppliedandEngineeringResearches,MinistryofScienceandTechnology,StateofIsrael

State

2013–Present ScientificReviewPanel,MarylandStemCellResearchFund,BaltimoreMD

2013 ScientificReviewPanel,NYSTEMProgram,RestonVA

Institutional

2017 Reviewer,GraduateStudentFellowship–CellBio;Chair:Dr.MatthewZimmerman

2016–Present Reviewer,GraduateStudentFellowship–DrugDevelopment;Chair:Dr.RakeshSingh

PATENTSIssuedPatents

1. NieS,MohsAM,ManciniMC,inventors;EmoryUniversity,assignee.Integratedsystemandmethodsforreal-timeanatomicalguidanceinadiagnosticortherapeuticprocedure.UnitedStatespatentUS9,451,882.2016Sept27.

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2. NieS,MohsAM,ManciniMC,inventors;EmoryUniversity,assignee.Additionalsystemsandmethodsforprovidingreal-timeanatomicalguidanceinadiagnosticortherapeuticprocedure.UnitedStatespatentUS9,345,389.2016May24.

PendingPatents

1. Mohs AM, Svechkarev D, PayneWM. Tunable fluorescent organic nanoparticles andmethodsofmakingandusingthesame.UnitedStatesprovisionalpatentapplicationUS62/459,082.2017Feb15.

2. MohsAM,HillTK,KridelSJ.FAS InhibitorsandMethodsAssociatedTherewith.UnitedStatesprovisionalpatentapplicationUS15/328,797.2017Jan24.

3. Mohs AM, Kridel SJ. Hyaluronic Acid-Based Nanoparticles as Biosensors for Imaging-GuidedSurgeryandDrugDeliveryVehiclesandMethodsAssociatedTherewith.UnitedStatesprovisionalpatentapplicationUS15/326,694.2017Jan10.

4. ZongY,LuZR,MohsAM,FengY,inventors;UniversityofUtahassignee.BiodegradablemacromolecularMRIcontrastagentsandmethodsofpreparationandusethereof.UnitedStatesprovisionalpatentapplicationUS60/814,449.2006June16.

ActiveTechnologyDisclosures

1. MohsAM,SvechkarevD,PayneWM.Tunablefluorescentorganicnanoparticles.UNMCref:17015.(Disclosure:September20,2016).

2. MohsAM,SvechkarevD,PayneWM.Polymer-basedStainingandSensingAgents.UNMCref:17014(Disclosure:September20,2016).

CONSULTINGPOSITIONS2014–Present AssociateEditor,FrontiersinPharmacology:IntegrativeandRegenerative

Pharmacology

2011–2012 SeniorScientificConsultant,Spectropath,Inc.,Atlanta,GA

ManuscriptAdHocReviewer(ImpactFactor)

ActaBiomaterialia(6.319)ACSAppliedMaterialsandInterfaces(7.504)ACSNano(13.334)AdvancedDrugDeliveryReviews(15.606)AdvancedFunctionalMaterials(11.382)AmericanJournalofRoentgenology(2.731)Analytical&BioanalyticalChemistry(3.578)AnalyticalChemistry(5.636)BioconjugateChemistry(4.513)Biomaterials(8.387)

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ColloidsandSurfacesB:Biointerfaces(4.125)Endocrine-RelatedCancer(5.267)EuropeanPolymerJournal(3.242)IEEETransactionsonBiomedicalEngineering(3.577)JournalofAppliedPolymerScience(1.600)JournalBiomedicalApplications(2.082)JournalofPhotochemistryandPhotobiologyA:Chemistry(2.625)MedicalPhysics(2.635)MolecularPharmaceutics(4.384)Nanomedicine:Nanotechnology,Biology,andMedicine(6.692)NatureNanotechnology(35.267)PharmaceuticalResearch(3.420)PLOSONE(3.057)ScientificReports(5.228)Small(8.315)TranslationalResearch(4.652)

MILITARYSERVICENone.

HONORSANDAWARDS2014 WakeForestComprehensiveCancerCenterNominee,Pew-StewartScholars

ProgramforCancerResearch

2010 InnovationoftheYear(IntegratedImagingandSpectroscopySystemforImage-GuidedSurgery)–awardedbytheEmoryOfficeofTechnologyTransfer

2006–2011 Emory–GeorgiaTechCenterforCancerNanotechnologyExcellenceDistinguishedFellowship

2006 WolfPrize–awardedtoaUniversityofUtahCollegeofPharmacygraduatestudentforexcellenceinteaching,highestawardgivenbytheCollegeofPharmacy

2006 JeffreyA.FoxAward–awardedtoUniversityofUtah,Pharmaceuticsgraduatestudentfordedicationandservicetodepartment

2005 PhRMAFoundationPredoctoralFellowshipawardedbythePhRMAFoundation,Washington,DC

2005 Vice-Chair,StudentAdvisoryCommittee,PharmaceuticsandPharmaceuticalChemistry,UniversityofUtah

2002 EnzonFellowshipawardedbyEnzonInc.,Pistacaway,NJ

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2000 St.John’sUniversityStudyAbroadProgramattheUniversityofSalzburg

1999–2000 SiehlScholarship–awardedbySt.John’sUniversityforacademicexcellenceandleadership

1998–2002 President’sScholarship–awardedbySt.John’sUniversity,basedonacademicachievement,service,andleadership

1998–2002 RecognitionScholarshipforStudentsinScience–awardedbySt.John’sUniversity,basedonacademicachievementinscience

MEMBERSHIPS/OFFICESINPROFESSIONALSOCIETIESMemberships

AmericanAssociationforCancerResearch(AACR)AmericanAssociationofPharmaceuticalScientists(AAPS)AmericanChemicalSociety(ACS)ControlledReleaseSociety(CRS)WorldMolecularImagingSociety(WMIS)

SocietyandNationalOrganizationServiceContributions

2017 Abstract Reviewer, World Molecular Imaging Congress, WorldMolecularImagingSociety

2016 UNMCAAPSStudentChapterEarly-stageCareerDevelopmentPanelist

2014 Vice-Chair, Regenerative Imaging and SensingWorkingGroup; TissueEngineeringandRegenerativeMedicineInternationalSociety

2012 SessionChair,CancerImaging,BiomedicalEngineeringSocietyAnnualMeeting

2013–2014 Selection Committee Chair, Wake Forest Institute of RegenerativeMedicine Young Investigator Award; Tissue Engineering andRegenerativeMedicineInternationalSociety

2013–2014 Abstract Reviewer, Cancer Technologies, Biomedical EngineeringSocietyAnnualMeeting

2013 Invited Faculty Panelist on Career Development at the BiomaterialsGordonResearchSeminar;Holderness,NH

2013 Abstract Reviewer, Imaging Technologies, Tissue Engineering andRegenerativeMedicineInternationalSociety

2011–2012 Chair, Nanomaterials/NanoformulationsWorking Group, NCI AllianceforNanotechnologyinCancer

2008 Participant, NIST-ASTM sponsored interlaboratory study (ILS) onnanotechnologystandardization

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2007–2010 Participant,NCIWorkingGrouptosetstandardsfornanotechnologyasachemicalandbiologicaltechnologyforcancerinformatics,detection,andtreatment

COMMITTEEASSIGNMENTSUniversityofNebraskaMedicalCenter

July2016–Present PharmaceuticalSciencesGraduateProgramCommittee(Chair:Dr.JeredGarrison)

June2016–Sept.2016 CollegeofPharmacyBusinessManagerSearchCommittee(Chair:Dr.ChristopherShaffer)

Jan.2016–Present CancerResearchGraduateProgramCommittee(Chair:Dr.JoyceSolheim)

July2015–Present Member,AdmissionsCommittee,UNMCCollegeofPharmacy(co-Chairs:Drs.ChristopherShafferandCharlesKrobot)

WakeForestUniversityHealthSciences

July2013–Mar.2015 BiomedicalEngineeringSociety(BMES)WakeForestStudentChapterFacultyAdvisor

July2012–Mar.2015 WakeForestInstituteforRegenerativeMedicineDepartmentalAnimalCareandUseCommitteeReviewer

Sept.2011–Mar.2015 WakeForest–VirginiaTechSchoolofBiomedicalEngineeringandSciencesFacultysearchcommittee

DoctorofPhilosophyGraduateStudentCommittees

Oct.2017–Present Chair,GraduateCommitteeforMadelineOlsen(UNMC-CRGP);Chair:Dr.AaronMohs

June2016–Present Chair,GraduateCommitteeforBowenQi(UNMC-PSGP);Chair:Dr.AaronMohs

May2016–Present Chair,GraduateCommitteeforNickWojtynek(UNMC-CRGP);Chair:Dr.AaronMohs

Aug.2015–Present Chair,GraduateCommitteeforWilliamPayne(UNMC-PSGP);Chair:Dr.AaronMohs

Aug.2015–Present Chair,GraduateCommitteeforDeepBhattacharya(UNMC-PSGP);Chair:Dr.AaronMohs

May2015–Present Member,GraduateCommitteeforYiChen(UNMC-PSGP);Chair:Dr.DavidOupicky

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Aug.2016–Present Member,GraduateCommitteeforYuHang(UNMC-PSGP);Chair:Dr.DavidOupicky

Aug.2014–Present Member,GraduateCommitteeforEllieMcCabe(WFUHS-MolecularMedicine);Chair:Dr.NicoleLevi-Polyachenko(WFUHS)

Aug.2011–June2017 Member,GraduateCommitteeforEtaiSapoznik(WFUHS-BiomedicalEngineering);Chair:Dr.ShaySoker

Feb.2017–May2017 Member,GraduateCommitteforYinnongJai(UNMC-PSGP);Chair:Dr.JeredGarrison

Aug.2012–Dec.2015 Member,GraduateCommitteeforBenjaminRowe(WFUHS-Physiology/Pharmacology);Chair:Dr.GeorgeChrist(WFUHS)

Aug.2012–Aug.2015 Member,GraduateCommitteeforHannahBaker(WFUHS-BiomedicalEngineering);Chair:Dr.GeorgeChrist(WFUHS)

June2012–July2015 Member,GraduateCommitteeforRiuWang(WFUHS-BiomedicalEngineering);Chair.Dr.WilliamWagner(WFUHS)

Aug.2011–May2015 Member,GraduateCommitteeforJohnP.McQuelling(WFUHS-BiomedicalEngineering);Chair:Dr.EmmanuelOpara(WFUHS)

Jan.2012–Apr.2015 Chair,GraduateCommitteeforTannerHill(WFUHS-BiomedicalEngineering);Chair:Dr.AaronMohs(WFUHS)

Jun.2012–Apr.2015 Co-Chair,GraduateCommitteeElizabeth(Graham)Gurysh(WFUHS-BiomedicalEngineering);Chair:Dr.NicoleLevi-Polyachenko(WFUHS),Co-Chair:Dr.AaronMohs(WFUHS)

Aug.2011–Jan.2015 Member,GraduateCommitteeforJohnScott(WFUHS-BiomedicalEngineering);Chair:Dr.GeorgeChrist(WFUHS)

MasterofScienceGraduateStudentCommittees

Aug.2014–Jun.2015 Chair,GraduateCommitteeforWilliamPayne(WFUHS-BiomedicalEngineering);Chair:AaronMohs(WFUHS)

Aug.2011–May.2012 Member,GraduateCommitteeforRiuWang(WFUHS-BiomedicalEngineering);Chair:Dr.WilliamWagner(WFUHS)

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PRESENTATIONSInternational,National,andRegionalMeetings

1. MohsAM.Fluorescenthyaluronicacidnanoparticlesenhancepancreaticcancerinmiceforsurgicalnavigation.ContrastMediaResearch;Durango,CO,October2017.

2. MohsAM(Invited).Image-guidedsurgeryusingnearinfraredfluorescentnanoparticles.NanoBioChina2016the1stSymposiumonMinimallyInvasiveandImageGuidedSurgery;Nanjing,China,October2016.

3. MohsAM.Image-guidedsurgeryfortumorremovalusinghyaluronicacid-derivednearinfraredfluorescentnanoparticles.10thWorldBiomaterialsCongress;Montreal,Canada,May2016.

4. MohsAM. IntraoperativeImagingUsingNear InfraredFluorescentHyaluronicAcid.7thAnnualSino-U.S.JointResearchForum;Omaha,NE,May2016.

5. Kelkar SS, Hill TK, Payne WM,Mohs AM. Near Infrared Fluorescent Self-AssembledNanoparticles for Image-Guided Surgery; Materials Research Society Fall Meeting &Exhibit;Boston,MA,December2015.

6. MohsAM,HillTK,KelkarSS,MariniFC,Levine,E.HyaluronicAcidDerivedNanoparticleswithActivatableFluorescenceforImage-GuidedTumorSurgery;BiomedicalEngineeringSocietyAnnualMeeting;SanAntonio,TX,October2014.

7. Mohs AM, Raghavan S, Gilmont R, Somara S, Marini FC, Bitar KN. Near InfraredFluorescent Neural Progenitor Cells to Track Differentiation and Tissue Innervation;BiomedicalEngineeringSocietyAnnualMeeting;SanAntonio,TX,October2014.

8. MohsAM.NanotechnologyforMinimallyInvasiveCancerDetectionandResection;NCIAlliance for Nanotechnology in Cancer InvestigatorsMeeting; Rockville, MD, October2014.

9. Mohs AM. Near Infrared Fluorescent Protein Labeling of Enteric Nerve Cells:Development and Initial Characterization of IM-FEN-iRFP Cells, North Carolina TissueEngineering and RegenerativeMedicine Society AnnualMeeting;Winston-Salem, NC,October2013.

10. Mohs AM. Nanotechnology for Image-Guided Intervention: Potential for ProstateCancer?, Prostate Cancer Research and Translation Symposium; Winston-Salem, NC,March2013.

11. MohsAM,ManciniMC,QianX,WangY,ProvenzaleJM,NieS.NanotechnologyforGuidedTumor Resection, NCI Alliance for Nanotechnology in Cancer Investigators Meeting;Houston,TX,November2012.

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12. Mohs AM, Wang Y, Qian X, Mancini MC, Provenzale J, Nie S. Nanotechnology forSpectroscopic and Image-Guided Tumor Resection, Biomedical Engineering SocietyAnnualMeeting;Atlanta,GA,October2012.

13. MohsAM.Tumorcellmarker imaging:searchingforthemicrometastasesthatchangethegame,RSNA/ASTROCancerImagingandRadiationTherapySymposium;Atlanta,GA,April2011(co-presentersProvenzaleJMandManciniMC).

14. MohsAM.Laser-guidedwidefieldimagingandspectroscopyforguidanceduringsurgicalresectionoftumors,FitzpatrickInstituteforPhotonicsAnnualMeeting;DukeUniversity,Durham,NC,October2010(copresentersManciniMC,ProvenzaleJM).

15. MohsAM,ManciniMC,ProvenzaleJM,SinghalS,WangMD,NieS.Ahand-heldimagingand spectroscopy device for intraoperative, contrast-enhanced tumor detection,BiomedicalEngineeringSocietyAnnualMeeting;Austin,TX,October2010.

16. MohsAM,RazaSH,White,WB,KaddiC,ManciniMC,NieS,WangMD,SinghalS.Thedevelopment of a novel endoscope to visualize residual tumor cells following cancersurgery,AmericanCollegeofSurgeons95thAnnualClinicalCongress;Chicago,IL,October2009.

17. Mohs AM, Smith AM, Mancini MC, Wen MM, Nie S. Investigating the Interactions,Consequences,andApplicationsofNanoparticlesatBiologicalInterfaces,NCIAllianceforNanotechnologyinCancerInvestigatorsMeeting;Chicago,IL,September2008.

18. MohsAM,ZongY,GoodrichKC,ParkerDL,LuZR.PEG-g-(GdDTPA-co-L-cystine):effectofPEG chain lengthon in vivo contrast enhancement inMRI,UtahCenter forAdvancedImagingResearch17thAnnualSymposium;SaltLakeCity,UT,October2005.

19. MohsAM,WangX,ZongY,GoodrichKC,ParkerDL,LuZR.PEG-g-(GdDTPA-co-L-cystine):abiodegradablemacromolecularcontrastagentforbloodpoolMRimaging,UtahCenterforAdvancedImagingResearch16thAnnualSymposium;ParkCity,UT,November2004.

InvitedExternalInstitutionPresentations

1. Mohs AM. Biomedical imaging and nanotechnology: An example of how clinicalchallenges guide scientific innovation, Glen Arth Seminar Series, College of St.Benedict/St.John’sUniversity;St.Joseph,MN,November2016.

2. Mohs AM. Contrast-enhanced fluorescence for intraoperative imaging. Frank ReidyResearchCenterforBioelectrics(FRRCBE),OldDominionUniversity;Norfolk,VA,October2016.

3. MohsAM.Hyaluronan-derivednanoparticlesforbiomedicalapplications:Experiencesinimaging and drug delivery. China Pharmaceutical University; Nanjing, China, October2016.

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4. MohsAM. The Role of CancerNanotechnology for Intraoperative Imaging, College ofEngineering,UniversityofNebraskaatLincoln;Lincoln,NE,April2016.

5. MohsAM.CancerNanotechnology:ApplicationsforImage-GuidedSurgery;DepartmentofChemistry,UniversityofNebraskaatOmaha;Omaha,NE,April2016.

6. MohsAM.NanotechnologyforContrast-EnhancedFluorescence-GuidedSurgery;LI-CORBiosciences;Lincoln,NE,December2015.

7. MohsAM.Nanotechnology for Image-GuidedTumorSurgery;BiomedicalEngineering,UniversityofSouthDakota;SiouxFalls,SD,September2014.

8. MohsAM.HyaluronicAcidDerivedNanoparticles for Image-GuidedSurgery andDrugDelivery;Chemistry,WakeForestUniversity;Winston-Salem,NC,September2014.

9. Mohs AM. Nanotechnology for Emerging Biomedical Applications, Joint School forNanoscience andNanoengineering atUNCGreensboro andNCA&T,Greensboro,NC,November2012.

10. MohsAM.Nanotechnologyformedicalandsurgicalimaging:currentstatusandfuturepossibilities, Duke Radiology Grand Rounds; Durham, NC, January 2011 (co-presenterProvenzaleJM).

11. Mohs AM.Wide-field optical imagingwith interactive excitation and spectroscopy toresectcontrast-enhancedtumors,NortheasternUniversity;Boston,MA,January2011.

12. MohsAM.Wide-fieldopticalimagingusingpointexcitationandspectroscopyforimage-guidedresectionofcontrast-enhancedtumors,UTSouthwesternMedicalCenter;Dallas,TX,November2010.

13. MohsAM.Quantumdotsforcellularandmolecularimaging:unusualopticalpropertiesandcellulartoxicity,InvitedspeakeratUTDallas;Richardson,TX,November2010.

14. MohsAM.IntegratedSpectroscopyandImagingforIntraoperativeCancerDetectionandSurgicalOncology,CaseWesternReserveUniversity;Cleveland,OH,January2010.

COMMUNITYSERVICE/OUTREACH2012 Sciencefairevaluator-SherwoodForestElementary(Winston-Salem,NC)

PUBLICATIONSA) PublishedJournalArticles1. PayneWM,SvechkarevD,KyrychenkoA,MohsAM.Theroleofhydrophobicmodification

onhyaluronicaciddynamicsandself-assembly.CarbohydPolym.2018;182:132-141.

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2. SvechkarevD,KyrychenkoA,PayneWM,MohsAM.Developmentofcolloidallystablecarbazole-basedfluorescentnanoaggregates.J.Photochem.PhotobiolA.2018;352:55-64.

3. BogdanD, SvechkarevD,ArnulfR, TromayerM, LiskaR,MohsAM,VautheyE.Directobservationofaphotochemicalalkyne-allenereactionandofatwistedandrehybridizedintramolecularcharge-transferstateinadonor-acceptordyad.J.Am.Chem.Soc.2017InPress.DOI:10.1021/jacs.7b09591.PMID:29068229

4. BhattacharyaD,SvechkarevD,Souchek JJ,HillTK,TaylorMA,NatarajanA,MohsAM.ImpactofstructurallymodifyinghyaluronicacidonCD44 interaction. JMaterChemB.2017;DOI:10.1039/C7TB01895A.

5. PayneWM,HillTK,SvechkarevD,HolmesMB,SajjaB,MohsAM.Multimodal imagingnanoparticles derived from hyaluronic acid for integrated preoperative andintraoperativecancer imaging.ContrastMediaMol Imaging.2017;Article ID9616791.PMID:29097944

6. SouchekJJ,DavisAL,HillTK,HolmesMB,QiB,SinghPK,KridelSJ,MohsAM.Combinationtreatmentwithorlistat-containingnanoparticlesandtaxanesissynergisticandenhancesmicrotubule stability in taxane-resistant prostate cancer cells.Mol Cancer Ther.2017;16(9):1819-1830.PMID:28615298

7. ZarifpourM,AnderssonK-E,KelkarSS,MohsA,MendelsohnC,SchneiderK,MariniF,ChristGJ.Characterizationofamurinemodelofbioequivalentbladderwoundhealingand repair followingsubtotal cystectomy.BioresOpenAccess.2017;6(1):35–45.PMID:28560089

8. HillTK,KelkarSS,WojtynekNE,SouchekJJ,PayneWM,StumpfK,MariniFC,MohsAM.Near infrared fluorescent nanoparticles derived from hyaluronic acid improve tumorcontrast for image-Guided surgery. Theranostics. 2016;6(13):2314–2328. PMID:27877237

9. YoonY,MohsAM,ManciniMC,NieS,ShimH.Combinationofanintegrin-targetingNIRtracerandanultrasensitivespectroscopicdeviceforintraoperativedetectionofheadandneck tumor margins and metastatic lymph nodes. Tomography. 2016;2(3):215–222.PMID:27738656

10. KelkarSS,HillTK,MariniFC,MohsAM.Nearinfraredfluorescentnanoparticlesbasedonhyaluronic acid: Self-assembly, optical properties, and cell interaction.Acta Biomater.2016;36:112–21.PMID:26995504

11. HillTK,DavisAL,WheelerFB,KelkarSS,FreundEC,LowtherWT,KridelSJ,MohsAM.DevelopmentofaSelf-AssembledNanoparticleFormulationofOrlistat,Nano-ORL,with

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IncreasedCytotoxicityagainstHumanTumorCellLines.MolPharm.2016;13(3):720–8.PMID:26824142

12. Hill TK,Mohs AM. Image-guided tumor surgery: will there be a role for fluorescentnanoparticles?WIREsNanomedNanobiotechnol.2016;8(4):498–511.PMID:26585556

13. NiuG,SapoznikE,LuP,CriswellT,MohsAM,WangG,LeeS-J,XuY,SokerS.Fluorescentimagingofendothelialcellsinbioengineeredbloodvessels:theimpactofcrosslinkingofthescaffold.JTissueEngRegenMed.2016;10(11):955–966.PMID:24616385

14. Stevenson AT, Reese LM, Hill TK, McGuire J, Mohs AM, Shekhar R, Bickford LR,Whittington AR. Fabrication and characterization of medical grade polyurethanecomposite catheters for near-infrared imaging. Biomaterials. 2015;54:168–76. PMID:25907050

15. HillTK,AbdulahadA,KelkarSS,MariniFC,LongTE,ProvenzaleJM,MohsAM.Indocyaninegreen-loaded nanoparticles for image-guided tumor surgery. Bioconjug Chem.2015;26(2):294–303.PMID:25565445

16. MohsAM*,ManciniMC,Provenzale JM, SabaCF,Cornell KK,HowerthEW,Nie S.Anintegrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. IEEE Trans Biomed Eng. 2015;62(5):1416–1424. PMID:25585410.*Denotescorrespondingauthor.

17. OpieAMT,BennettJR,WalshM,RajendranK,YuH,XuQ,ButlerA,ButlerP,CaoG,MohsAM,WangG.Studyofscanprotocolforexposurereductioninhybridspectralmicro-CT.Scanning.2014;36(4):444–55.PMID:24604215

18. BennettJR,OpieAMT,XuQ,YuH,WalshM,ButlerA,ButlerP,CaoG,MohsA,WangG.Hybridspectralmicro-CT:systemdesign,implementation,andpreliminaryresults. IEEETransBiomedEng.2014;61(2):246–53.PMID:23996533

19. Provenzale JM, Mohs AM. Nanotechnology in neurology-current status and futurepossibilities.USNeurol.2010;6(1):12–17.

20. MohsAM,ManciniMC,SinghalS,ProvenzaleJM,Leyland-JonesB,WangMD,NieS.Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrastenhancement, detection sensitivity, and tissue penetration. Anal Chem.2010;82(21):9058–65.PMID:20925393

21. MohsAM, Provenzale JM. Applications of nanotechnology to imaging and therapy ofbraintumors.NeuroimagingClinNAm.2010;20(3):283–92.PMID:20708547

22. MohsAM,DuanH,KairdolfBA,SmithAM,NieS.Proton-resistantquantumdots:stabilityingastrointestinalfluidsandimplicationsfororaldeliveryofnanoparticleagents.NanoRes.2009;2(6):500–508.PMID:20379372

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23. Smith AM,Mohs AM, Nie S. Tuning the optical and electronic properties of colloidalnanocrystalsbylatticestrain.NatNanotechnol.2009;4(1):56–63.PMID:19119284

24. SmithAM,DuanH,MohsAM,NieS.Bioconjugatedquantumdotsforinvivomolecularandcellularimaging.AdvDrugDelivRev.2008;60(11):1226–40.PMID:18495291

25. FengY,JeongE-K,MohsAM,EmersonL,LuZ-R.Characterizationoftumorangiogenesiswith dynamic contrast-enhanced MRI and biodegradable macromolecular contrastagentsinmice.MagnResonMed.2008;60(6):1347–52.PMID:19025902

26. Mohs AM, Lu Z-R. Gadolinium(III)-based blood-pool contrast agents for magneticresonanceimaging:statusandclinicalpotential.ExpertOpinDrugDeliv.2007;4(2):149–64.PMID:17335412

27. MohsAM,NguyenT,JeongE-K,FengY,EmersonL,ZongY,ParkerDL,LuZ-R.ModificationofGd-DTPA cystine copolymerswithPEG-1000optimizespharmacokinetics and tissueretention for magnetic resonance angiography.Magn Reson Med. 2007;58(1):110–8.PMID:17659618

28. Zong Y, Guo J, Ke T, Mohs AM, Parker DL, Lu Z-R. Effect of size and charge onpharmacokineticsandinvivoMRIcontrastenhancementofbiodegradablepolydisulfideGd(III)complexes.JControlRelease.2006;112(3):350–6.PMID:16631270

29. Lu Z-R, Mohs AM, Zong Y, Feng Y. Polydisulfide Gd(III) chelates as biodegradablemacromolecular magnetic resonance imaging contrast agents. Int J Nanomedicine.2006;1(1):31–40.PMID:17722260

30. ZongY,WangX,GoodrichKC,MohsAM,ParkerDL,LuZ-R.Contrast-enhancedMRIwithnew biodegradable macromolecular Gd(III) complexes in tumor-bearing mice.MagnResonMed.2005;53(4):835–42.PMID:15799038

31. MohsAM,ZongY,GuoJ,ParkerDL,LuZ-R.PEG-g-poly(GdDTPA-co-L-cystine):effectofPEG chain length on in vivo contrast enhancement in MRI. Biomacromolecules.2005;6(4):2305–11.PMID:16004476

32. MohsAM,WangX,GoodrichKC, ZongY, ParkerDL, Lu Z-R. PEG-g-poly(GdDTPA-co-L-cystine): a biodegradablemacromolecular blood pool contrast agent forMR imaging.BioconjugChem.2004;15(6):1424–30.PMID:15546211

B)ChaptersinBooks

1. KelkarSS,MohsAM.TranslationalImagingforRegenerativeMedicine.InTranslationalRegenerativeMedicine;AtalaA,AllicksonJ,Eds.;AcademicPress:Elsevier:Waltham,MA,2015;pp257-265.

C) MediaFeatures

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RelatedtomansucriptMohsAM,etal.AnalChem.2010;82(21):9058–65.PMID:20925393.

Chemical&EngineeringNews,October15,2010. Optics&PhotonicsNews,January1,2011

RelatedtomanuscriptMohsAM,etal.IEEETransBiomedEng.2015;62(5):1416–1424.PMID:25585410.

IEEETransBiomedEngCoverandFeaturearticle.ScienceDaily,January20,2015.PhotonicOnline,January20,2015.WSJSMohsRadioInterview.

D) AbstractsandPreliminaryCommunications(10of48;presenterunderlined)1. Qi B, Crawford AJ, Holmes MB, Wojtynek NE, Souchek JJ, Almeida-Porada G,

Hollingsworth MA, Mohs AM. Indocyanine green loaded hyaluronan-derivednanoparticles for fluorescence-enhanced surgical imaging of an orthotopic pancreaticcancer model. World Molecular Imaging Congress; Philadelphia, PA, September2017.PodiumPresentation.

2. Svechkarev D, Payne WM, Mohs AM. Colloidal stability and spectral properties ofcarbazole-based fluorescent nanoaggregates. 17th IEEE International Conference onNanotechnology;Pittsburgh,PA,July2017.Poster.

3. PayneWM,SvechkarevD,KyrychenkoA,MohsAM.Computationalmodelsofpolymericnanoparticlesforrationaldesignindrugdelivery.GordonResearchConferenceonCancerNanomedicine;MountSnow,VT,June2017.Poster.*SelectedforPodiumPresentation.

4. BhattacharyaDS,SvechkarevD,Souchek JJ,Hill TK,TaylorM,NatarajanA,MohsAM.TuninghyaluronicacidbindingpropertiestoCD44usingsynthetic, invitroandinsilicoapproaches. 253rd American Chemical Society National Meeting and Exposition; SanFrancisco,CA,April2017.Poster.

5. HillTK,KelkarSS,SouchekJJ,PayneWM,MariniFC,MohsAM.Nearinfraredhyaluronan-derived nanoparticles for fluorescence image-guided tumor surgery. Imaging in 2020;JacksonHole,WY,September2016.Poster.

6. SouchekJJ,HillTK,DavisAL,QiB,HolmesMB,SinghPK,KridelSJ,MohsAM.Combinationtreatment with Nano-Orlistat and taxanes is synergistic and enhances microtubulestability in taxane-resistant prostate cancer cells. 14th International Nanomedicine &DrugDeliverySymposium(NanoDDS);Baltimore,MD,September2016.Poster.*Selectedfor “Rapid Fire Presentation” and awarded Society for Biomaterials-Drug DeliverySpecialInterestGroupResearchAward

7. Payne WM, Svechkarev DA, Boska MD, Mohs AM. Multimodal contrast agents forintegrated preoperative and intraoperative cancer imaging. AACR Engineering andPhysicalSciencesinOncology;Boston,MA,June2016.Poster.

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8. SouchekJJ,HillTK,DavisAL,QiB,SinghPK,KridelSJ,MohsAM.Nano-orlistatsynergizeswithtaxanesintaxane-resistantprostatecancercells.7thAnnualSino-U.S.JointResearchSymposium,May2016,UNMC,Omaha,NE.Poster.*FirstPlacePosterPresentationandCashprize.

9. HillTK,AbdulahadA,KelkarSS,MariniFC,LongTE,ProvenzaleJM,MohsAM.Indocyaninegreen-loadednanoparticlesimprovetumorcontrastforimage-guidedsurgery.NanoDDS;Seattle,WA,September2015.Poster.

10. HillTK,DavisAL,WheelerFB,KelkarSS,FreundEC,LowtherWT,KridelSJ,MohsAM.Nanoparticle formulation of orlistat improves drug stability and cytotoxicity againsthumancancercelllines.NanoDDS;Seattle,WA,September2015.Poster.

TEACHINGACTIVITIESA. DidacticCoursework

UniversityofNebraskaMedicalCenter(Sept.2015–Fall2017)

Course(Role): PharmaceuticalSciencesI,PHSC570(Instructor) Duties: Preparedandpresentedlecturesrelatedtomicromeritics.LecturesGiven: 3

Course(Role): PharmaceuticalSciencesII,PHSC670(Instructor) Duties: Preparedandpresentedlecturesrelatedtozeroandfirst-orderrate

equations,compartmentmodeling,andphysiologically-basedpharmacokinetics.

LecturesGiven: 23

Course(Role): PharmaceuticalSciencesIII,PHSC672(Instructor) Duties: Preparedandpresentedlecturesrelatedtotheconceptsandmodeling

ofpharmacokinetic-pharmacodynamicrelationshipsandmodifiedreleasepharmacokinetics.

LecturesGiven: 10

Course(Role): PharmaceuticalScienceApplicationsinPharmacy,PHSC691(Instructor)

Duties: Preparedandgavelectureonnanotechnologyforimage-guidedsurgery

LecturesGiven: 3

Course(Role): PharmaceuticalsSciencesGraduateProgramSeminar,PHSC970(Co-Coordinator)

Duties: Scheduledseminarsandorganizedtheitineraryofinvitedspeakers;maintainedstudentattendance

Non-lecturehours: 80

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WakeForestUniversityHealthSciences(Sept.2011–March2015)

Course(Role): QuantitateOrganSystemsPhysiology,BMES606(CourseDirector,Instructor)

Duties: Arrangedschedulestointegratemathematicalmodeling,simulation,quantitativedescriptionoforganphysiologyandcontrol,andsupervisesemesterproject.

LecturesGiven: 27Non-lecturehours: 90

Course(Role): MedicalImagingII,BMES751(Instructor)Duties: Preparedandgavelecturesonthechemistryofcontrastagentsand

principlesofcontrastenhancedmagneticresonanceimagingandcomputedtomography.

LecturesGiven: 4

Course(Role): DrugDiscovery,DesignandDevelopment,CHM740(Instructor) Duties: Preparedandgavelecturestointroducepharmaceuticalsciencesto

chemistryundergraduateandgraduatestudents,includingadsorption,distribution,metabolism,excretion,andcontrolledrelease.

LecturesGiven: 4

Course(Role): IntroductiontoRegenerativeMedicine,BMES631(Instructor)Duties: Preparedandgavelectureondrugdeliveryintissueengineeringand

regenerativemedicine.LecturesGiven: 1

Course(Role): EngineeringApproachestoTreatingCancer,BMES5984(Instructor)Duties: Preparedagavealectureonusingnanotechnologyfordetecting,

diagnosing,andtreatingcancerLecturesGiven: 1

Course(Role): TopicsinCancerBiology,MCB723(Instructor) Duties: Preparedandgavelectureoncancerimaging.LecturesGiven: 1

B. TeachingRelatedtoUndergraduate/Graduate/PostdoctoralResearchersStudent: WilliamPayne–GraduateStudent

2017-2018BlueWatersGraduateFellowship(6awardednationally);2017UNMCgraduatestudentofdistinction

Program: PharmaceuticalSciences(UNMC);MSBiomedicalEngineering(WFUHS)

Student: DeepS.Bhattacharya–GraduateStudent 2017-2019ProgramofExcellenceAssistantshipRecipientProgram: PharmaceuticalSciences(UNMC)

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Student: BowenQi–GraduateStudentProgram: PharmaceuticalSciences(UNMC)

Student: NicholasWojtynek–GraduateStudentProgram: CancerResearch(UNMC)

Student: MadelineOlsen–GraduateStudentProgram: CancerResearch(UNMC)

Student: TannerHill–GraduateStudent,PostdoctoralFellow2014-2015MikeandLucyRobbinsFellowshipAward(WakeForest)foracademic,research,andleadershipexcellence

Program: BiomedicalEngineering(WFUHSasgraduatestudent);PharmaceuticalSciences(UNMCaspostdoctoralfellow)

Student: DenisSvechkarev,PhD–PostdoctoralFellowProgram: PharmaceuticalSciences

Student: JoshuaSouchek,PhD–PostdoctoralFellowProgram: PharmaceuticalSciences

Student: JoeGeraldJesuRaj,PhD–PostdoctoralFellowProgram: PharmaceuticalSciences

Student: SnehaKelkar,PhD–PostdoctoralFellowProgram: BiomedicalEngineering

Student: NoahReed–UndergraduateStudentProgram: UNMCSummerUndergraduateResearchProgram(attendsUniversityof

NebraskaatLincoln)

Student: ChaojunWang–UndergraduateStudentProgram: AsiaPacificRimDevelopmentProgram(attendedXi'anJiaotong

UniversityHealthScienceCenter,China)

Student: EricaFreund–UndergraduateStudentProgram: PhysicsHonorsThesisAdvisor(attendedWakeForestUniversity)

Student: GillianLloyd–UndergraduateStudentProgram: UndergraduateTrainee(attendedWakeForestUniversity,Major:

Biology)

Student: JoshuaCopus–UndergraduateStudentProgram: WakeForestInstituteforRegenerativeMedicineSummerScholar

(attendedClemsonUniversity,Major:BiomedicalEngineering)

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21

Student: XiangxiGao–UndergraduateStudentProgram: WakeForest–VirginiaTechBiomedicalEngineeringSummerScholar

(attendedEmoryUniversity,Major:Math,Biology)

Student: KindellSchmitt–UndergraduateStudentProgram: WakeForest–VirginiaTechBiomedicalEngineeringSummerScholar

(attendedVirginiaTech,Major:BiologicalSystemsEngineering)

Student: MarthaKahlson–UndergraduateStudentProgram: WakeForestInstituteforRegenerativeMedicineSummerScholar

(attendedMountHolyokeCollege,Major:Biochemistry)

Student: RobertJohnson,II–UndergraduateStudent Program: NHLBIExcellenceinCardiovascularSciencesProgram(attendedJohnson

C.SmithUniversity,Major:Biology)

Student: FlorenceMcCarty–UndergraduateStudentProgram: NHLBIExcellenceinCardiovascularSciencesProgram(attendedJohnson

C.SmithUniversity,Major:Biology)