ΑΒΧ≅!∃∆ΕΦ∆∃ Γ∋4/∃ !∀#∃%&∋()∗+∃,∀−.&/+/0&1∗+∃2)3 ... · 2011....
TRANSCRIPT
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Acronym Topic Project type
VPH NoE Networking N o E
VPHOP Osteoporo s i s I P
euHeart Heart/CV disease I P
ARTreat CV/Atheroschlerosi s I P
preDiC T Heart/CV disease STREP
ContraCancrum Cancer STREP
ARCH Vascular/AVF & haemodialys is STREP
PASSP O R T Liver/surgery STREP
Predic tAD Alzheimers/BM & diagnosis STREP
NeoMA R K Oral cancer/BM, D & T STREP
V P H 2 Heart/LVD surgery STREP
IMPPACT Liver cancer/RFA therap y STREP
HAMAM Breast cancer/diagnos is STREP
Action-Grid Grid access EU – LA & Balkans C A
RADICAL Security and privacy in V P H C A
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Name
seedEP1 SAPHIR: A multi-organ Core Model of arterial pressure and body fluids homeostasis
(CNRS, Evry)
seedEP2 IMUS: integrated multi-level modeling of the musculoskeletal system (ULB, IOR)
seedEP3 WHAM: "Modeling human disease in the presence of model and parameter
uncertainty" (KI)
seedEP4 Towards quantitative assessment of drug safety by multiscale and molecular simulation
tools (IMIM/GRIB)
seedEP5 Modeling and visualizing brain function and pathophysiology (ERCIM/ICS-Forth)
EP6 (Call 1) Establishing ontology-based methods to improve interoperability between data and
models for the VPH ToolKit: the Guyton case study (EBI, CNRS, UoA, Univ. Wash.)
EP7 (Call 2) CIGENE: Integrating genetic theory and genomic data with multiscale models in a
population context
EP8 (Call 2) The NoE, Infrastructure and the Challenge of Call6
EP9 (Call 2) VIP for VPH : Execution of medical image simulation workflows on DEISA through
workflow interoperability between the Virtual Imaging Platform and the VPH toolkit
EP10 (Call 3) Environment for Sexually Transmitted Infection Modelling
EP11 (Call 3) Vascular Tissue Modelling Environment (VTME)
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⊥α/ΠΠΠ∀
BIOSYS 2006
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!/:∗∋
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(∀&∋.(∃
Β]2∃
1/4(∋/+∃
>..)#∃χ)&
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ς[∀
• ∃∋#0)+∗(/∋−∃.−.(#3.∃∗1(∃
/α#∋∃3#∃.1∗+#.∃
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
Γ+///4Η∃3)+>Ω/∋0∗4∃&4(#0∋∗>/4∃
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3#∃.1∗+#.∃
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∃∃∃∃∃∃∃∃∃∃Ω∃3∗4−∃.−.(#3.∃∗∋#∃&4α/+α#
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26
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
Ο4∃(∀#∃+/40Ω(#∋39∃:#∃3).(∃=#∃&4∃:∗(#∋∃∗4
-
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders. ςω∀
-
Defects of renal transporters are implicated in health problems.
These are pharmacological targets with inter-connected relationships.
ςΖ∀
Μ_%6%3∗6Φ∀∋Π∀%3∀;ΒΠ∀ΜςΨΨεΝΠ∀∋∃./0∗Β∀Υ%Θ∀ΖεΜςΝ2∀ξωΤΛω!εΠΝ∀
Gittelman’s syndrome: PA↓, RAAS ↑ compensation par ENaC Gordon’s syndrome:
(PHA typeII)
PA ↑ PRA & Aldo ↓
Bartter’s syndrome:
PA ↓ , PRA ↑ & Aldo ↑
α-adducin: essential hypertension
-
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Synchronisation & simulation
adaptatives
Synchronisation &
simulation à pas fixe
Synchronisation à pas fixe &
simulation adaptative
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9.6>∃4∗60µ;Α∗6∀
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temps
O2 I1
M2 M1
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, ∀ΞΧι%>3Λ∗40%63%∆∀∀
, ∀⊥0/340Χ≅3%∆∀;??4∗;>∃∀
Modèle
couplé Coordinateur
Modèle
couplé
Modèle
atomique
Modèle
atomique
Modèle
atomique Coordinateur
Simulateur Simulateur
Simulateur
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?∆Ν⊥∃Ξ.#∋∃Ο4(#∋;∗1#∃
• ∀Ζ/4(∋/+∃?∆Ν⊥∃.&3)+∗>/4Κ∃
• ∀_;60?≅Β;3%∀_ς9Κ∀/01≅Β;Α∗6∀?;4;1%3%4/Π∃
• ∀ϑ∃;6Ε%∀1∗∆%Β∀?;4;1%3%4/∀Χ%:∗4%∀;6∆∀∆≅406Ε∀/01≅Β;Α∗6Π∀
• ∀ΞΧ/%4Θ%∀1∗∆%Β∀∃0%4;4>∃.∀;6∆∀Θ;40;ΧΒ%/∀Μ06?≅3/Φ∀∗≅3?≅3/Φ∀?;4;1%3%4/Ν∀06∀4%;ΒΛΑ1%Π∀
• ∀9%;4>∃∀Θ;40;ΧΒ%/∀Χ.∀6;1%Π∀
• ∃⊥/∗
-
87/∀:∗4∀⊥Ω+_Κ∀φ∀_ς9Κ∀
%6%4;Α∗6∀∗:∀;6∀
]_Κ∀Μ⊥Ω+_ΚΝ∀ΙΒ%∀
]9Κ#∀
_ς9Κ∀ΜϑυυΝ∀ α_∀
_;=%ΙΒ%∀∀
_ς9Κ2∀
);ΑΘ%∀Β0Χ4;4.∀
(#_Κ∀
_;3Β;Χ∀
-
_∗∆≅Β;4∀/./3%1/Λ1∗∆%Β∀∗:∀ΧΒ∗∗∆∀?4%//≅4%2∀Χ4%;=∆∗%1%63∀1∗∆%Β/∀:∗4∀
06∆0Θ0∆≅;Β∀1∗∆≅Β%/2∀∀
∀,∀ϑ&9Φ∀Β≅6ΕΦ∀=0∆6%.∀
Model
Properties
Operations
TissueE!ect
Properties
Operations
ThirstDrinking
Properties
Operations
RedBloodCells
Properties
Operations
PulmonaryDynamics
Properties
Operations
PlasmaTissue
Properties
Operations
MuscleBloodFlow
Properties
Operations
LocalBloodFlowControl
Properties
Operations
KidneySaltOut
Properties
Operations
Kidney
Properties
Operations
Hemodynamics
Properties
Operations
HeartViciousCycle
Properties
Operations
HeartRate
Properties
Operations
HeartHypertrophy
Properties
Operations
Guyton
Properties
Operations
GelProtein
Properties
Operations
GelFluid
Properties
Operations
Electrolytes
Properties
Operations
CapillaryMembrane
Properties
Operations
BloodViscosity
Properties
Operations
AutonomicControl
Properties
Operations
AntidiureticHormone
Properties
Operations
AngioControl
Properties
Operations
AldoControl
Properties
Operations
AdaptBaroreceptor
Properties
Operations
VascularStressRelax…
Properties
Operations
-
]#(∗&+#Ω.1∗+#∃#ϑ(#4.&/4.∃∗4
-
_∗∆≅Β;4∀/./3%1/Λ1∗∆%Β∀∗:∀ΧΒ∗∗∆∀?4%//≅4%2∀∀
∴0∆6%.∀1∗∆≅Β%∀
≅.3∗6Φ∀ΩΠϑΠΦ∀#ΠΠ∀ϑ∗Β%1;6Φ∀;6∆∀(Π}Π∀4;6Ε%4Φ∀λϑ04>≅Β;Α∗62∀ΞΘ%4;ΒΒ∀4%Ε≅Β;Α∗6Πλ∀∀
Ω66≅;Β∀Υ%Θ0%1∃
α∗./1/4.(∋&1(/∋∃#Ρ#1(∃/4∃
∗∋(#∋.∃
%Ο?Η∃Γ+//1∃7∋#..)∋#∃
,,ΖΗ∃7+∗.3∗∃Ζ,∃
ΠΓΑΗ∃Π#4∗+∃Γ+///4∃
ΖΧ≅Η∃(∀&∋7+∋∃
Β?Η∃∗+7+∋∃
Ξ!,Ξ!Ν∃
Χ]Η∃∋∗(#∃/;∃∋#4∗+∃Χ∗µ∃
#ϑ1∋#>/4∃
%Ξ]Η∃∋∗(#∃/;∃)∋&4#∃/)(7)(
%Ο?∃,Β∃
,,Ζ∃ΠΓΑ∃ Π≅β∃ Χ]∃
%Ξ]∃
ΖΧ≅Β2?∃Β?∃
ΒΞ?∃
afferent,
efferent, &
resistance
glomerular
volume
sodium
reabsorption/
excretion
renal blood flow
-
_∗∆≅Β%∀ΥΩΩ9∀∀ΜΥ%606ΛΩ6Ε0∗3%6/06ΛΩΒ∆∗/3%4∗6%Λ9./3%1Ν∀
ΡΠ∀≅0ΒΒ;≅∆∀φ∀∋Π∀(;66;%43∀Μ∋∗0Α%4/Ν∀
∋406>0?;Β∀9∗≅4>%/2∀αΥ+)⊥Ω∀∼∀9>∃.6#&∋)&7)∃6ΓΟ)ΩΞΞΘ)Ρ)Τ.∗∗)&7)(Σ./∃Ο)ΩΞΞΖ)Ρ)Σ64#&/≅&65)&7)∃6ΓΟ)
ΩΞΞΞ)Ρ);&∋−−./)&7)∃6ΓΟ)ΦΠΠα)Ρ)Σ∃5&∋)&7)ς∃/7&/Ο)ΦΠΠΠ)Ρ)ς∋β/Χ&∋%&∋)&7)∃6ΓΟ)ΦΠΠ_)Ρ)χ∋2δ8?∃∗(−∃/.)&7)∃6ΓΟ)ΦΠΠ_)Ρ)χ∋2δ8?∃∗(−∃/.)&7)∃6ΓΟ)ΦΠΠΘ)Ρ);&28;&7&∋5()&7)∃6ΓΟ)ΦΠΠα)Ρ)
Η∃4%/&∋)&7)∃6ΓΟ)ΩΞ⊥Ω)Ρ)Η∃4%/&∋)&7)∃6ΓΟ)ΩΞ⊥α)Ρ)Λ&34&(∋∃)Με∗&δ)&7)∃6ΓΟ)ΦΠΠα)Ρ);&/7δ)&7)∃6ΓΟ)ΦΠΠΘΓΓΓ))
:4∗1∀δ)&++∗)04>≅Β;Α6Ε∀4%606Λ
;6Ε0∗3%6/06∀/./3%1∀;6∆∀ΧΒ∗∗∆∀?4%//≅4%∀4%Ε≅Β;Α∗6Πλ∀Ω>3;∀α0∗3∃%∗4∀εΖΜςΛΣΝ2∀![ΣΛ!ωΨΠ∀
-
ως∀Θ/Π∀Τς∀Θ/Π∀ΥΩΩ9∀1∗∆%Β∀
-
(0Ε∃%4ΛΥ%/∗Β≅Α∗6∀1∗∆%Β/2∀∀
∋≅Β/;ΑΒ%∀1∗∆%Β/∀∗:∀3∃%∀∃%;43∀ΜΚ#97Ν∀
– +;>∃∀Θ%6340>Β%∀0/∀4%?4%/%63%∆∀;/∀;∀/06ΕΒ%∀
>∗634;>ΑΒ%∀%Β%1%63Φ∀Χ.∀1%;6/∀∗:∀;∀Θ;40;ΧΒ%∀
%Β;/3;6>%∀1∗∆%Β∀
• 8/06Ε∀1∗Θ06Ε∀;Θ%4;Ε%∀063%4:;>%∀>∗1?∗6%63/∀
:∗4∀06?≅3Λ∗≅3?≅3∀>∗≅?Β06Ε∀3∀>∗≅?Β06Ε∀:∗4∀;∀:≅ΒΒΛ?≅Β/;ΑΒ%∀Θ%4/0∗6∀
Μ4%ν≅0406Ε∀4%Λ0∆%6ΑΙ>;Α∗6∀∗:∀3∃%∀ως∀
?;4;1%3%4/Ν∀
Ω∀∃0Ε∃%4Λ4%/∗Β≅Α∗6∀Ρ+_∀1∗∆%Β∀∗:∀3∃%∀Κ&∀
063%Ε4;Α6Ε2∀
Ω∀?;Α%63Λ/?%>0Ι>∀Ε%∗1%34.∀∗Χ3;06%∆∀:4∗1∀ϑ#∀01;Ε%/∀
Ω∀1∗4%∀∆%3;0Β%∆∀%Β%>34∗Λ1ζ>;6∗Λ∃.∆4;≅Β0>∀1∗∆%Β∀
_∗Θ06Ε∀;Θ%4;Ε%∀063%4:;>%∀
-
Τς∀9%6/0ΑΘ03.∀;6;Β./0/∀;6∆∀
Ε%6%4;Α∗6∀∗:∀;∀&043≅;Β∀∋∗?≅Β;Α∗6∀
• )#∗∀%6;ΧΒ%∀>∗1?;40/∗6∀∗:∀;Β3%46;ΑΘ%∀∗4∀1∗4%∀∆%3;0Β%∆∀
1∗∆≅Β%/)
• ∀Ω/∀;∀Ε≅0∆%∀:∗4∀(/)−(6(0.∀%Γ?Β∗4;Α∗6∀∗:∀∆4≅Ε∀%Η%>3/Φ∀Ε%6%Α>∀?∗Β.1∗4?∃0/1/Φ∀%3>Π∀
-
• ∃Ολ∃3∗7.∃/;∃(∀#∃∆ν∃3/∃∀1∗∆≅Β%2∀?Β∗3/∀∗:∀;ΒΒ∀∗≅3?≅3∀Θ;40;ΧΒ%/∀;/∀:≅6>Α∗6∀∗:∀%;>∃∀06?≅3Φ∀
∗Θ%4∀;∀4%Β%Θ;63∀?∃./0∗Β∗Ε0>;Β∀4;6Ε%∀∗:∀Θ;Β≅%/∀
• ∀Ζ/37∋#∀#4.&α#∃.#4.&>α&(−∃∗4∗+−.&.∀Μ7α79ϑ∀3%;1Ν∀
• 9%6/0ΑΘ03.∀∗:∀ςΤω∀/./3%1∀Θ;40;ΧΒ%/∀3∗∀%;>∃∀∗:∀Τξ∀/%Β%>3%∆∀?;4;1%3%4/∀;3∀
ε∀106ΠΦ∀!∃Φ∀!∆;.Φ∀;6∆∀[∀;Β>≅Β;3%∆∀
• ∀#∃0/∀0/∀∆∗6%∀:∗4∀/.∋#∃6∀/3%;∆.∀/3;3%∀;6∆∀;Β/∗∀Μ3%Ν∀:∗4∀!ΨΨΨ∀Γ∀Τξ∀
4;6∆∗10µ%∆∀λ06∆0Θ0∆≅;Β/λ∀ΜMorris. 1991. "Factorial Sampling Plans for Preliminary Computational Experiments." Technometrics, 33(2): 161-174)∀
• ∀γ%∀∃;Θ%∀3∃≅/2∀
• ∀Θ043≅;Β∀?∗?≅Β;Α∗6∀∗:∀%6ΘΠ∀εΨΨ∀ΨΨΨ∀4;6∆∗10µ%∆∀06∆0Θ0∆≅;Β/Φ∀;6∆∀
• ∀1%;6∀∀9⊥∀∗:∀3∃%∀%Η%>3∀∗:∀%;>∃∀?;4;1%3%4∀∗6∀%;>∃∀Θ;40;ΧΒ%Φ∀;6∆∀
;Β/∗∀%/Α1;3%/∀063%4;>Α∗6/∀;1∗6Ε∀3∃%∀?;4;1%3%4∀%Η%>3/∀Μ>∗Θ;40;6>%∀
;6;Β./0/∀?4∗Θ0∆%/∀∆%3;0Β/Ν∀
δ)−(/4∃5δε∆6Η∃Ζ/37∋#∀#4.&α#∃Ν#4.&>α&(−∃∗4∗+−.&.ΚΚΚ∃
-
δε∆∃0+/=∗+∃.#4.&>α&(−∃∗4∗+−.&.∃λ∃%;3?Β∗3/λ∀∗:∀1%;6/∀∗:∀%Β%1%63;4.∀%Η%>3/∀
[Σ∀
Θ;40;ΧΒ%/∀
?;4;1%3%4/∀
?;4;1%3%4/∀
Θ;40;ΧΒ%/∀
?#∗4∃α∗+)#.∃/;∃(∀#∃4/∋3∗+&ο#∃;6Ε%∀∗:∀Θι∀∃;6Ε%∀∗:∀%;>∃∀?;4;1%3%4∀Μ∗6%Λ;3Λ;ΛΑ1%Φ∀!Ψ∀
∗:∀;ΒΒ∗3/∀;4%∀/∃∗∃;6Ε%Φ∀;/∀1;4=%∆Π∀#∃%∀Ε4;?∃∀0/∀34≅6>;3%∆∀;3∀∀!Π∀∀
∀∀∀ϑΒ%;4Β.Φ∀3∃%∀?;Ο%46/∀>∃;6Ε%∀∃∀?;4;1%3%4∀Μ∗6%Λ;3Λ;ΛΑ1%Φ∀!Ψ∀
∗:∀;ΒΒ∗3/∀;4%∀/∃∗∃;6Ε%Φ∀;/∀1;4=%∆Π∀#∃%∀Ε4;?∃∀0/∀34≅6>;3%∆∀;3∀∀!Π∀∀
∃∃∃Ζ+#∗∋+−9∃(∀#∃7∗π#∋4.∃1∀∗40#∃:&(∀∃>3#∃∗θ#∋∃(∀#∃7∗∋∗3#(#∋∃7#∋()∋=∗>/4.Κ∃∃
-
λ_∗440/∀?Β∗3/λ∀∗:∀1%;6/∀;6∆∀/3;6∆;4∆∀∆%Θ0;Α∗6/∀Μ9⊥+&Ν∀∗:∀
6∗41;Β0µ%∆∀%Η%>3/∀∗:∀;ΒΒ∀?;4;1%3%4/∀∗6∀3∃%∀Θ;40;ΧΒ%∀
λ∋Ωλ∀∗(∃;/)∋∃>3#.∃∗θ#∋∃7#∋()∋=∗>/4∃
≅ϑ∗37+#∃/;∃.#4.&>α&(−∃∋#.)+(.∃;/∋∃∃
(∀#∃α∗∋&∗=+#∃ρ,Βρ∃5∗∋(#∋&∗+∃=+///4∃/;∃∗++∃ες∃3/
-
λ_∗440/∀?Β∗3/λ∀∗:∀1%;6/∀;6∆∀/3;6∆;4∆∀∆%Θ0;Α∗6/∀Μ9⊥+&Ν∀∗:∀
6∗41;Β0µ%∆∀%Η%>3/∀∗:∀;ΒΒ∀?;4;1%3%4/∀∗6∀3∃%∀Θ;40;ΧΒ%∀λ∋Ωλ∀∗(∃
;/)∋∃>3#.∃∗θ#∋∃7#∋()∋=∗>/4∃Μϑ)Υ2∀4%:%4%6>%∀/∗∆0≅1∀>∗6>%634;Α∗6∀3∗∀∆%3%4106%∀Ω⊥(∀/%>4%Α∗6∀4;3%Ν∀
≅ϑ∗37+#∃/;∃.#4.&>α&(−∃∋#.)+(.∃;/∋∃∃
(∀#∃α∗∋&∗=+#∃ρ,Βρ∃5∗∋(#∋&∗+∃=+///4∃/;∃∗++∃ες∃3//4.∃:&(∀∃/(∀#∋∃
7∗∋∗3#(#∋.∃∀
ΨΠΨ∀1%;6/∀∀9⊥+&∀
?;4;1%3%4/∀
#Ρ#1(.∃/4∃,Β∀
ϑ)Υ∀
1/α∗∋&∗41#∃/;∃ΖΧΠ∃
#Ρ#1(.∃:&(∀∃∗++∃
/(∀#∋∃7∗∋∗3#(#∋.∀
-
76∀;∆∆0Α∗6∀3∗∀3∃%∀/%6/0ΑΘ03.∀;6;Β./0/2∀
Κ;4Ε%∀∋∗?≅Β;Α∗6∀∗:∀∀
λ&043≅;Β∀Μ≅.3∗6Ν∀76∆0Θ0∆≅;Β/λ∀
Υ;6∆∗10µ%∆∀?;4;1%3%4/∀"∀;6;Β∗Ε∗≅/∀3∗∀λ%&/.7=∗&λ∀
#∃0/∀4%/≅Β3/∀06∀;∀Θ;40%3.∀∗:∀Θ043≅;Β∀λ∗
-
_≅ΒΑ?Β∗3/∀3∗∀Θ0/≅;Β0µ%∀/%6/0ΑΘ03.∀4%/≅Β3/∀
-
%&∋()∗+∃ρδ)−(/4Ω7/7)+∗>/4ρΗ∃∃,∗∋∗3#(#∋.∃3/.(∃&37+&1∗(#/4∃
∀!Τς∀ΨΨΨ∀λΘ043≅;Β∀06∆0Θ0∆≅;Β/λ∀/4∃;/∋∃7∋/(#&4∃/4∃
βΠδΧ ∃0∗&4∃/;∃7/.&>α#∃;##
-
• ∀Θ043≅;Β∀?∗?≅Β;Α∗6∀
∗:∀ςΨΨ∀ΨΨΨ∀Θ043≅;Β∀
06∆0Θ0∆≅;Β/∀"∀
%Γ?Β∗4;Α∗6∀∗:∀6∗Θ%Β∀
4%Β;Α∗6/∃0?/∀;1∗6Ε∀
3∃%∀?Β%3∃∗4;∀∗:∀
?;4;1%3%4/∀φ∀
Θ;40;ΧΒ%/∀
γ%Χ∀063%4:;>%∀:∗4∀∆;3;Χ;/%∀∗:∀/%6/0ΑΘ03.∀4%/≅Β3/∀
-
∗6/34≅>Α∗6∀∗:∀;∀Ε4;?∃∀∗:∀1∗∆%ΒΛ/34≅>3≅4%∀
-
QKDB (Quantitative Kidney DataBase)
Ζ+&1Ι&40∃/4∃/4#∃/;∃(∀#∃∋#;#∋#41#.∃
=∋&40.∃)7∃∗∃;Β∀:%;3≅4%/Φ∀34;6/?∗43∀?;4;1%3%4/Φ∀η∗∗6>%634;Α∗6/Φ∀34;6/?∗43%4∀=06%Α>/Φ∀%3>Π∀
⊥.6;10>∀/>4∗ΒΒΛ∆∗∗6340Χ≅3%∆∀Χ.∀
3∃%∀∃∀>∗11≅603.∀
-
QKDB : what's there?
-
QKDB (Quantitative Kidney DataBase) %∀
• Χ%Ο%4∀063%Ε4;Α∗6∀063∗∀∗3∃%4∀4%/∗≅4>%/∀
• 6%/Θ∀ΙΒ%/∀
– ;≅3∗1;Α>;ΒΒ.∀Ε%6%4;3%∀Ε4;?∃/∀∗:∀/%;4>∃∀4%/≅Β3/∀
– 76>∗4?∗4;Α∗6∀∗:∀6%Β%/∀
-
Ω≅3∗1;Α>∀06:∗41;Α∗6∀%Γ34;>Α∗6∀Χ;/%∆∀∗6∀ο∴⊥α∀∆%/>40?3∗4/∀Ω66%ΛΚ0/%∀_06;4∆Φ∀Υζ10∀⊥%Β∗41%Φ∀α40Ε0Ο%∀4;≅Φ∀Ω66%ΛΚ;≅4%∀Κ0Ε∗µ;3∀Μ+)977+Ν∀
-
ΞΧι%>ΑΘ%/2∀
Α∋/3∃3∗4−∃0//;Βλ∀1∗∆%Β/∀∗:∀=0∆6%.∀:≅6>Α∗6∀• ∀≅.3∗6∀1∗∆%Β/∀∗:∀α∋∀4%Ε≅Β;Α∗6∀
• ∀7=%∆;∀1∗∆%Β∀∗:∀;>0∆ΛΧ;/%∀4%Ε≅Β;Α∗6∀
• ∀∆;3;∀:4∗1∀>Β060>;Β∀340;Β/∀;6∆∀?∗?≅Β;Α∗6∀/3≅∆0%/∀• ∀:≅6>Α∗6;Β∀∆;3;∀:4∗1∀%Γ?%401%63;Β∀1∗∆%Β/∀
• ∀?∗;Β∀3∗∗Β/∀Μ5∀_ς9Κ5Ν∀• ∀3;Β%63%∆∀>∗ΒΒ;Χ∗4;3∗4/∀
• ∀5∀
!/:∗∋0%/∀∗:∀%Γ?%401%63;Β∀1∗∆%Β/Ν∀
• ∀λ4%Λ≅/%;ΧΒ%λΦ∀≅1%63%∆Φ∀/3;6∆;4∆/ΛΧ;/%∆Φ∀%3>ΠΦ∀:∗4∀3∃%∀∋∃./0∗1%−&∋(∀
763%4;>ΑΘ%∀87∀:∗4∀_ς9Κ∀1∗∆%Β/∀
Modèle
couplé Coordinateur
Modèle
couplé
Modèle
atomique
Modèle
atomique
Modèle
atomique Coordinateur
Simulateur Simulateur
Simulateur
Formalisme Continu Formalisme Discret
Hiérarchie de modèles Hiérarchie de simulateurs _ς9Κ∀∀
tubule transport models built-up from kinetic descriptions of transporters
counter-current recycling in medullary nephron loops and blood vessels
=0∆6%.∀1∗∆%Β/∀;3∀1;6.∀/>;Β%/∀
-
SAPHIR & BIMBO collaborators
IBISC (FRE 3190) & IR4M UMR8081
• SR Thomas
• Thibault Grosse (CDD VPH) • Rob Moss (postdoc BIMBO) • Stana Agnes (Ing IGR) • Pierre Mazière (postdoc SAPHIR) • Jérôme Bazin (CDD VPH NoE)
MC ENSIIE : Brigitte Grau, Anne-Laure Ligozat, Amel Bouzeghoub, Anne-Lise Minard
MC IBISC : Fariza Tahi, Farida Zehraoui, Nadia Abchiche, Tarek Melliti
http://saphir.ibisc.fr/
LTSI INSERM U.642 Rennes
Alfredo Hernandez Virginie LeRolle, David Ojeda, Guy
Carrault, Mireille Gareau
TIMC/PRETA UMR 5525 CNRS Grenoble
Pierre Baconnier Julie Fontecave-Jallon, Pascale Calabrese,
Enas Abdulhay
INSERM U927, Poitiers
Patrick Hannaert François Guillaud
U. Paris VI Jean-Pierre Françoise
NASA Ron White∀
BIMBO team (Lyon)
François Gueyffier Ivanny Marchand, Alexandra Laugerotte, Thierry Dumont