7. chris van hoof new 100313dl

7/27/2019 7. Chris Van Hoof New 100313DL

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BioMEMS

Enabling Killer Apps inHealthcare & Lifestyle


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Chronic diseasesstem in large partfrom lifestyle related

risk factors

BioMEMSEnabling Killer Appsin

Healthcare & Lifestyle

Chris Van Hoof, imec, Belgium


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LAST MONTH


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I LEARNED ABOUT MYHEALTH RISKS


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risk factors

HEALTH=

Genetics

Bill Davenhall, geo-medicine guru, ESRI


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LANDSCAPE OF POC DX

Type Benchtop Portable Smartphone

Where? Clinical lab Clinical lab or Drsoffice

Home or Drs office

What? Expensive and dedicatedinstrument, low-costdisposable

Lower cost dedicatedinstrument, low-cost

disposable

No instrument. Morefunctions integrated into

disposable. Data processing

in smartphone or cloud.

Instrument cost $10-100k $5-20k $0

Disposable cost $10-200 $10-200 $0.50-10

Well-servicedSolutions exist

Nocompelling

solutions on

the market

yet


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disposablemicrofabricated

test

flexible:blood,saliva,

urine

smartphone

healthtracking

app +

webservices

iLabTECHNICAL CONCEPT

Wireless link

ONE PLATFORM - MANY MARKERS

DNA/RNA Mutations miRNA: marker for cancer and other diseases Pathogen DNA/RNA: infectious diseases (HepC,

HIV, et.)

Proteins Biomarkers for disease (cancer, Alzheimers,

infectious diseases, heart disease, etc.)

Small molecules and metabolites Metabolic information (e.g. cholesterol)

Microscopy Blood cell count (e.g. HIV CD4+) Blood disorders (e.g. sickle cell anemia)


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disposablemicrofabricated

test

flexible:blood,saliva,

urine

smartphone

healthtracking

app +

webservices

Detection chip

~1 cm

2-4 cm

Fluidics chip

PCB with

radio,

power,

control

Package

Exploded view

iLabTECHNICAL CONCEPT

Wireless link


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200MM BIOMEMS WAFER


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inlets outlet

MICRO-PILLAR ARRAY FILTER

Injection volume

200m

supply

c

hannel

distributor

micro-pillars

50m 5m

injection area distribution area separation area


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Chip-PCR

Conv.PCR

MICRO-REACTOR FOR DNA

AMPLIFICATION


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http://www.diginfo.tv/v/13-0022-r-en.phpPanasonic-imec result

HALF CREDIT CARD SIZE BIOMEMSachieving on-chip DNA amplification and detection from whole blood sample

SEPARATION OF 11 DNA STRANDS IN 2CM LONG CHANNELDNA fragments are 10, 15, 20, 25, 35, 50, 75, 100, 150, 200 and 300bp


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risk factors

HEALTH=

Genetics+Lifestyle

+ Environment



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risk factors

3lifestyle-related RISK FACTORS

are responsiblefor all chronic diseases


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PREVENTIONTRACK RISK FACTORS & ADAPT LIFESTYLE

Raised blood pressure

Raised blood glucose

Overweight/obesity

Abnormal blood lipids

Unhealthy diet

Physical inactivity

Tobacco use

Behavioral / lifestylerisk factors

GENETICS

ENVIRONMENT

Intermediate risk factors

Heart disease | Stroke | Cancer |Chronic pulmonary diseases | Diabetes

MAIN CHRONIC DISEASES


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REDUCING DIABETES AND

HYPERTENSION PREVALENCEBY 5% WOULD SAVEAPPROXIMATELY

$9 BILLION ANNUALLY IN THENEAR TERM

PREVENTION WORKS !


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Reviewo

ver1Mp

eople

Source:Wo

odcocketal,Int

JofEpidemiolog

y,2010Reduction in global risk

mortality by increasingphysical activity

PREVENTION WORKS !


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Totalexpenditur

eonheal

th,

%

GDP

OECD dataad

1970 1980 1990 2000 2008

16

14

12

10

8

6

4

UNITED STATES

GERMANY

SWITZERLAND

UNITED KINGDOM


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Technology should

EMPOWERpeople towards

disease prevention


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QUALITY OF DATA

DESIRABLEFORMFACTOR

LOWCOST

LOWPOWER

REQUIRES RADICALINNOVATIONS

inSENSOR, CIRCUIT, SYSTEM, INTEGRATION

TECHNOLOGY, ALGORITHM & DATA ANALYTICS


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KILLER APPS

THAT

SAVE LIVES


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risk factors

KILLER APP #1

STAY FIT


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18kcal/kg/day 4.3kcal/kg/day

THE ADVERSE EFFECT OF

EVOLUTION


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WITH DRAMATIC CONSEQUENCES


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NEEDS A BEHAVIOR CHANGE


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A MULTITUDE OF DEVICES


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IMEC CIRCUITS SYSTEMS &


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IMECs CIRCUITS, SYSTEMS &ALGORITHMS FOR ENERGY EXPENDITURE

90%Accuracy

Reliablein everyday situations

1 monthAutonomy


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GRAND CHALLENGE: ENERGY INTAKE

imec HYPERSPECTRAL SENSOR

imec PHYSIOLOGICAL SENSOR

CHANGING BEHAVIOR IS TOUGH


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CHANGING BEHAVIOR IS TOUGH


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risk factors

KILLER APP #2

MANAGESTRESS


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Stressed person


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30-40%

25%

4/10

$42-300B

STRESS MANAGEMENT APPS


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STRESS MANAGEMENT APPS

STRESS BIOMARKERS


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Sympathetic

and

Parasympathetic

Autonomic

Nervous

System

Heart rate

Respiration rate

Salivation

Perspiration

Pupil dilation

STRESS BIOMARKERS

EMERGING t l


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EMERGING tools


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Parametersmeasured today

Skin conductance3D-accelerometerSkin temperatureSkin humidityAmbient

temperature

Ambient humidity

STRESS AT WORK STRESS PATIENTS


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STRESS AT WORK

80% accuracyin classifying stress from rest

STRESS PATIENTS

75% accuracyin classifying patients from controls

SALIVA STRESS SENSOR


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SALIVA STRESS SENSOR


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Chronic diseasesstem in large part

from lifestyle related

risk factors

KILLER APP #3

DISPOSABLEHEALTH PATCH

REDESIGN FOR


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ROLL-TO-ROLLMANUFACTURING


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TAKEAN IMEC WIRELESS SENSOR DESIGN

ADAPT IT FOR FOIL INTEGRATION


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ADAPT IT FOR FOIL INTEGRATION


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INTEGRATE PASSIVES AND ICS

LOW-COST


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LOW COST

SKIN TEMPERATUREPATCH


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risk factors

HEALTH

=

Genetics+ Lifestyle

+ Environment



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risk factors

KILLER APP #4

KEEP YOUR

ENVIRONMENT IN

CHECK


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imec ENVIRONMENTAL NO2 SENSOR


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imec ENVIRONMENTAL NO2 SENSOR

CONTINUOUSMEASUREMENT

at ambient temperature

in varying humidity

EMERGING ppb NO2 MONITORING


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2

12 14 16 18 20 22-120

-100

-80

-60

-40

-20

0

Time (hours)

Relativeresponse(%)

Parking garage

Clean air in nature

EMERGING environmental MONITORING


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risk factors

Basic NOSE functionality: array of eNose sensors on single chip


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MEDICALQUALITY

DATA

IN

CONSUMERHANDS


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Technology

mustEMPOWERPEOPLE

towards disease prevention and towardsa healthier lifestyle

ENCOURAGE & MOTIVATE


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BioMEMSEnabling Killer Apps in

Healthcare & Lifestyle

7. chris van hoof new 100313dl

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