PATENT ABSTRACTS

pharmaceutical composition comprising the protein or fragments thereof.

5210185

H U M A N N E R V E G R O W T H F A C T O R

Valle Francesco Della, Lanfranco Callegaro, Sil- vana Lorenzi, Padova, Italy assigned to Fidia S p A

The present invention is directed to a method for the isolation of Human Nerve Growth Factor (HNGF) from human placenta. More par- ticularly, the invention is directed to the method of isolation of the beta-subunit of Human Nerve Growth Factor and Compositions containing the same for the treatment of neuropathological conditions.

5212057

B I O L O G I C A L S Y S T E M F O R C O N S T R U C T I N G A N D T E S T I N G

V I R A L V A C C I N E S

Richard W Moyer, David Bloom assigned to University of Florida

Disclosed is a novel biological system for 1) the evaluation of potential complications of live virus vaccines prior to actual testing in animals or in the field, and 2) the construction of vaccine vectors in which the ability to grow within specific organs or tissues has selectively been eliminated from the virus.

207

include a promoter region upstream from the multiple cloning site. The invention is ex- emplified with Bacillus. Specific secretory signal sequences have been isolated with those vectors, allowing for efficient secretion into the super- natant, and not just to the periplasmic space to provide proteins in economically high yields. Secretory sequences are provided superior to other previously known sequences.

5212074

G E N E T I C M A T E R I A L E N C O D I N G N E W I N S U L I N - L I K E G R O W T H

F A C T O R B I N D I N G P R O T E I N IGFBP-6

Michael C Kiefer, Frank R Masiarz assigned to Chiron Corporation

A purified binding protein selected from the group consisting of insulin-like growth factor bi- nding protein having an amino acid sequence which is at least 85% homologous to the amino acid sequence of FIG. 1 and fragments thereof comprising at least 10 consecutive amino acids of the sequence that are capable of binding to an antibody specific for the protein or to an insulin- like growth factor is described. Recombinant DNA molecules encoding the binding proteins and subsequences thereof are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for preparing the binding proteins by growing the recombinant hosts containing the relevant DNA molecules. Antibodies to the pro- tein, identified as IGFBP-6, which are useful in various diagnostic applications, are also described.

5212070

S E C R E T O R Y S I G N A L S E L E C T I O N V E C T O R S F O R E X T R A C E L L U L A R P R O T E I N S Y N T H E S I S IN B A C I L L I

Hilde E Smith, Jan H Van Ee, Ben P H Peeters, Sier Bron, Gerard Venema, Groningen, Nether- lands assigned to Gist-brocades

Novel vectors are provided for identifying secretory signal sequences from DNA fragments of unicellular microorganisms. The plasmids comprise a multiple cloning site with restriction sites in reading frame with a structural gent which permits rapid screening of the secreted ex- pression product. Optionally, the vectors may

5212084

R E T R O V I R U S A N D R E L A T E D M E T H O D U S E D F O R

P R O D U C I N G A M O D E L F O R E V A L U A T I N G T H E

A N T I R E T R O V I R A L E F F E C T S O F D R U G S A N D V A C C I N E S

Harold McClure, Patricia Fultz, Daniel C An- derson assigned to Emory University; Centers for Disease Control

A retrovirus and related method used in pro- ducing a model for evaluating the antiretroviral effects of drugs and vaccines includes the steps of