4975369

PATENT ABSTRACTS

R E C O M B I N A N T A N D C H I M E R I C K S I / 4 A N T I B O D I E S D I R E C T E D

A G A I N S T A H U M A N A D E N O C A R C I N O M A A N T I G E N

Lisa S Beavers, Thomas F Bumol, Robert A Gadski, Barbara J Weigel assigned to Eli Lilly and Company

The present invention comprises novel recom- binant DNA compounds which encode mono- clonal antibody KSI/4 and chimeric derivatives of monoclonal antibody KS1/4. Eukaryotic ex- pression vectors have been constructed that comprise novel KS 1/4-encoding DNA and drive expression of KSI/4 when transformed into an appropriate host cell. The novel expression vec- tors can be used to create modified and chimeric derivatives of KSI/4. The recombinant- produced KSI/4, KS1/4 derivatives and KSI/4 chimeras are useful for the diagnosis, prognosis and treatment of disease states including adenocarcinoma.

4975372

M I C R O B I A L T R A N S F O R M A T I O N P R O D U C T O F L-683 ,590

Byron H Arison, Edward S Inamine, Shieh- Shung T Chen, Linda Wicker assigned to Merck & Co Inc

Described is a new immunosuppressant, L- 685,487, a monodemethylated rearranged derivative ofL-683,590, produced under fermen- tation conditions utilizing the microorganism, unidentified Actinomycete (Merck Cultrue Col- lection MA 6474) ATCC No. 53828. The macro- lide immunosuppressant is useful in preventing human host rejection of foreign organ trans- plants, e.g. bone marrow and heart transplants.

4976958

M Y C O B A C T E R I A L R E C O M B I N A N T S A N D P E P T I D E S

Thomas Shinnick, Richar Houghten assigned to Scripps Clinic and Research Foundation

127

Recombinant 540 amino acid residue and 517 amino acid residue proteins encoded by the genome of Mycobacterium tuberculosis are dis- closed as are vectors for propagating their DNA sequences and expressing the proteins. Also dis- closed are methods for using those proteins. Pep- tides that correspond substantially to the sequences of those proteins and methods of their use are also disclosed, as are polymers con- raining peptide repeating units corresponding to the 540 residue protein and also polymers con- mining 517 protein pentapeptides as repeating units.

4976959

T - P A A N D S O D I N L I M I T I N G T I S S U E D A M A G E

Henry Berger, Crist Frangakis assigned to Bur- roughs Wellcome Co

A combination of t-PA and SOD of use in in- hibiting damage to jeopardized tissue during reperfusion in a mammal.

4977079

M E T H O D F O R T H E D E T E R M I N A T I O N O F A N T I - P . F A L C I P A R U M S P O R O Z O I T E

A N T I B O D I E S IN H U M A N B L O O D

Carlo A Nuzzolo, Adriano Bernardi, Antonello Pessi, Antonio S Verdini, Rome, Italy assigned to Eniricerche S p A

An immunoenzimatic method is disclosed for the detection and the measurement ofanti-P, fal- ciparum sporzoite antibodies in human blood and/or in its derivatives, which operates with a synthetic antigen-enzyme conjugate capable of forming with the antisporozoite antibodies a stable antibody-synthetic antigen-enzyme com- plex, and one or more proteins absorbed and/or covalently linked to a solid support, which eagerly bind the antisporozoite antibody of said complex. The method, thanks to its simpleness, specificity and rapidity, is particularly useful in epidemiologic investigations into malaria and into the efficacy of an antimalarial vaccine.