4569842 pharmaceutical composition containing a derivative of para-aminobenzoic acid as an active...

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New Patents vii tion comprising a water-soluble polymeric sub- stance having a Young's modulus of 10 to 250 Kg/mm2 as determined at a temperature of 25 degrees C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20 degrees C. and a medicinal agent for remedy of periodontal dis- eases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic sol- vent by drying to obtain a pharmaceutical pre- paration in the form of a film or sheet. 4569842 PHARMACEUTICAL COMPOSITION CONTAINING A DERIVATIVE OF PARA- AMINOBENZOIC ACID AS AN ACTIVE INGREDIENT Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando, Kunitachi, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha Disclosed is a pharmaceutical composition con- taining an aminobenzoic acid derivative as an ac- tive ingredient represented by the following general formula: See Patent for Chemical Struc- ture wherein 1R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1 (alpha) or 1 (beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof. 4570013 BIPHENYLYLALKANOIC ACID DERIVATIVES, METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREFROM Mario Bergamaschi, Gian B Gervasi, Vittori Vecchietti, Massimo Signorini, Monza, Italy as- signed to Dr L Zambeletti S p A Novel compounds of formula See Patent for Chemical Structure are described which have antipyretic, analgesic and antiinflammatory ac- tivity. R is hydrogen, C1-C3 linear or branched alkyl; R1 and R2 are hydrogen, halogen, unsub- stituted or esterified hydroxy, alcoxy, and may be the same or different; R3 is hydrogen, C 1-C4 linear or branched aliphatic acyl, unsubstituted or substituted aroyl, alkylaroyl or hetaroyl groups. 4571391 CHROMIUM ACETYLACETONATE AS A DIETARY SUPPLEMENT AND PHARMACEUTICAL AGENT Dennis P Riley, Mark Anderson, John Rotruck assigned to The Procter & Gamble Company Chromium(Ill) tris-acetylacetonate, a coordina- tively saturated, stable chromium(Ill) com- pound provides a dietary chromium supplement for humans and lower animals and is a useful hypoglycemic pharmaceutical agent for treating diabetes, especially when used in conjunction with insulin therapy. 4571400 DIHYDROCODEINE/IBUPROFEN PHARMACEUTICAL COMPOSITIONS AND METHOD John D Arnold assigned to Belleview Pharma- ceutical Inc Pharmaceutical compositions containing dihy- drocodeine or a pharmaceutically acceptable acid addition salt thereof and ibuprofen or a pharmaceutically acceptable salt thereof are use- ful in treating pain in mammals. 4571407 PHARMACEUTICAL COMPOSITIONS CONTAINING BILOBALID FOR THE TREATMENT OF NEUROPATHIES Shyam S Chatterjee, Bernard Gabard, Hermann E W Jaggy, Karlsruhe, Federal Republic Of Ger- many assigned to Dr Willmar Schwabe GmbH & Co Medicaments containing bilobalid which can be used to control nervous diseases are described.

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Page 1: 4569842 Pharmaceutical composition containing a derivative of para-aminobenzoic acid as an active ingredient

New Patents vii

tion comprising a water-soluble polymeric sub- stance having a Young's modulus of 10 to 250 Kg/mm2 as determined at a temperature of 25 degrees C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20 degrees C. and a medicinal agent for remedy of periodontal dis- eases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic sol- vent by drying to obtain a pharmaceutical pre- paration in the form of a film or sheet.

4569842

PHARMACEUTICAL COMPOSITION CONTAINING A

DERIVATIVE OF PARA- AMINOBENZOIC ACID AS AN

ACTIVE INGREDIENT

Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando, Kunitachi, Japan assigned to Kureha Kagaku Kogyo Kabushiki Kaisha

Disclosed is a pharmaceutical composition con- taining an aminobenzoic acid derivative as an ac- tive ingredient represented by the following general formula: See Patent for Chemical Struc- ture wherein 1R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1 (alpha) or 1 (beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

4570013

BIPHENYLYLALKANOIC ACID DERIVATIVES, METHODS OF

PREPARATION AND PHARMACEUTICAL

COMPOSITIONS THEREFROM

Mario Bergamaschi, Gian B Gervasi, Vittori Vecchietti, Massimo Signorini, Monza, Italy as- signed to Dr L Zambeletti S p A

Novel compounds of formula See Patent for Chemical Structure are described which have antipyretic, analgesic and antiinflammatory ac- tivity. R is hydrogen, C1-C3 linear or branched alkyl; R1 and R2 are hydrogen, halogen, unsub-

stituted or esterified hydroxy, alcoxy, and may be the same or different; R3 is hydrogen, C 1-C4 linear or branched aliphatic acyl, unsubstituted or substituted aroyl, alkylaroyl or hetaroyl groups.

4571391

CHROMIUM ACETYLACETONATE AS A

DIETARY SUPPLEMENT AND PHARMACEUTICAL AGENT

Dennis P Riley, Mark Anderson, John Rotruck assigned to The Procter & Gamble Company

Chromium(Ill) tris-acetylacetonate, a coordina- tively saturated, stable chromium(Ill) com- pound provides a dietary chromium supplement for humans and lower animals and is a useful hypoglycemic pharmaceutical agent for treating diabetes, especially when used in conjunction with insulin therapy.

4571400

DIHYDROCODEINE/IBUPROFEN PHARMACEUTICAL

COMPOSITIONS AND METHOD

John D Arnold assigned to Belleview Pharma- ceutical Inc

Pharmaceutical compositions containing dihy- drocodeine or a pharmaceutically acceptable acid addition salt thereof and ibuprofen or a pharmaceutically acceptable salt thereof are use- ful in treating pain in mammals.

4571407

PHARMACEUTICAL COMPOSITIONS CONTAINING

BILOBALID FOR THE TREATMENT OF NEUROPATHIES

Shyam S Chatterjee, Bernard Gabard, Hermann E W Jaggy, Karlsruhe, Federal Republic Of Ger- many assigned to Dr Willmar Schwabe GmbH & Co

Medicaments containing bilobalid which can be used to control nervous diseases are described.