180 PATENT ABSTRACTS

poultry animal diseased with proventriculitis: in- oculating a cell culture capable of sustaining the growth and replication of the reovirus; extra- cting the virus from cellular and nonviral com- ponents, and rendering the reovirus into a form suitable for administration to poultry, yields a vaccine and an immunization method.

4559306

M O D I F I E D P A S T E U R E L L A M U L T O C I D A B A C T E R I A

Carrell J Kucera assigned to Norden Laboratories Inc

The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bac- teria vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.

4559323

A41030 A N T I B I O T I C S

Karl Michel, Ralph E Kastner assigned to Eli Lilly and Company

Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fer- mentation of new Streptomyces virginiae N RRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity against Staphylococcus and Streptococcus species which are penicillin resistant. In addition, the antibiotic factors have shown inhibition of Streptococcus pneumonia Park I, The complex and the in- dividual factors enhance feed efficiency in ruminant animals, and are growth promoters in chickens and swine, and are especially valuable in milk production in dairy cattle.

4559338

S O L U B L E Q U I N A Z O L I N O - I , 4 - B E N Z O D I A Z E P I N - 5 , 1 3 - D I O N E

D E R I V A T I V E S

Mark G Bock, Roger M Freidinger, Ben E Evans assigned to Merck & Co lnc

Novel quinazolino- 1,4-benzodiazepin-5,13- dione derivatives, which are soluble in aqueous media and which have been found to be an- tagonists of the function of cholecystokinins

(CCK), to the preparation of these compounds from compounds prepared by aerobic fermenta- tion of certain Aspergillus alliaceus strains, and to the use of these compounds to antagonize the function of CCK, which antagonism is useful, e.g.. for the treatment and prevention of dis- orders of the gastrointestinal, central nervous and appetite-regulatory systems of mammals, especially of humans.

4559339

I N D O L - 3 - Y L - Q U I N A Z O L I N O - 1 , 4 - B E N Z O D I A Z E P I N - 5 , 1 3 - D I O N E S

Mark G Bock. Roger M Freidinger, Ben E Evans assigned to Merck & Co Inc

Novel indol-3-yl-quinazolino- 1,4- benzodiazepin-5,13-diones, which are an- tagonists of the function of cholecystokinins (CCK), to the preparation of these compounds from compounds prepared by aerobic fermenta- tion of certain Aspergillus alliaceus strains, and to the use of these compounds to antagonize the function of CCK, which antagonism is useful, e.g,, for the treatment and prevention of dis- orders of the gastrointestinal, central nervous and appetite-regulatory systems of mammals, especially of humans.

4560552

A N T I B I O T I C S

Martin Cole, Thomas T Howarth, Christopher Reading, Dorking, United Kingdom assigned to Beecham Group p I c

A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (1): See Patent for Chemical Structure (I) In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of beta lac- tam antibiotics against many beta-lactamase producing bacteria.

4560662

S T R E P T O M Y C E S A N T I B I O T I C U S A T C C 31771 A N D P R O C E S S F O R

O B T A I N I N G S A M E

Leonardo M Cappelletti, Roberto Spagnoli, Luciano Toscano assigned to Pierrel S p A