4 hydroxy mipt
DESCRIPTION
Monografia de SubstânciaTRANSCRIPT
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 1 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
NH
OH
NCH3
CH3
CH3
1. GENERAL INFORMATION
IUPAC Name:
CAS#:
Synonyms:
Source:
Appearance:
UVmax(nm):
3-{2-[methyl(propan-2-yl)amino]ethyl}-1H-indol-4-ol
77872-43-6
4-OH-MIPT, 4-hydroxy-N-methyl-N-isopropyltryptamine, hats, miprocin
DEA Reference Material Collection
Gray powder (base)
Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C14H20N2O 232 143.7
HCl C14H20N2O. HCl 268 Not Determined
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in CD2Cl2 containing TMS for 0 ppm reference and methenamine as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds1H NMR: 4-OH-MIPT Lot # 0438458-25; CD2Cl2; 400MHz
8 7 6 5 4 3 2 1 0
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
63231212
CD2Cl2 TMS
8.05 8.00
2
6.95 6.85
21
6.425 6.400
1
2.33 2.31
3
2.9 2.8 2.7
23
0.975 0.950
6
methenamine
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 3 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL in chloroform.
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC
MSD transfer line: 280oCMS Source: 230oCMS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 300oC at 12 oC/min3) Hold final temperature for 9.0 min
Injection Parameters: Split Ratio = 20:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu
Threshold: 100Tune file: stune.uAcquisition mode: scan
Retention Time: 12.228 minEI Mass Spectrum: 4-OH-MIPT Lot # 0438458-25
m/z220200180160140120100806040
[x 1
05 ]In
tens
ity
1
2
3
4
5
623
223
223
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223
223
223
223
223
223
2
217
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190
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174
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17416
016
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016
0
146
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102
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102
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102
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102
102919191 9191919191 9191919191 9191919191 91919191
868686 8686868686 8686868686 8686868686 86868686
777777 7777777777 7777777777 7777777777 77777777656565 6565656565 6565656565 6565656565 65656565565656 5656565656 5656565656 5656565656 56565656
444444 4444444444 4444444444 4444444444 44444444
EI+
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 4 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 8Aperture: 150
FTIR ATR (Diamond, 3 Bounce): 4-OH-MIPT Lot # 0438458-25
Wavenumber (cm-1)3500 3000 2500 2000 1500
%Tr
ansm
ittan
ce
40
48
56
64
72
3223322332233223322332233223322332233223322332233223322332233223322332233223322332233223
2972297229722972297229722972297229722972297229722972297229722972297229722972297229722972
2929292929292929292929292929292929292929292929292929292929292929292929292929292929292929
1576157615761576157615761576157615761576157615761576157615761576157615761576157615761576
15001500150015001500150015001500150015001500150015001500150015001500150015001500150015001462146214621462146214621462146214621462146214621462146214621462146214621462146214621462 1435
143514351435143514351435143514351435143514351435143514351435143514351435143514351435
1416141614161416141614161416141614161416141614161416141614161416141614161416141614161416
1346134613461346134613461346134613461346134613461346134613461346134613461346134613461346
1261126112611261126112611261126112611261126112611261126112611261126112611261126112611261
1157115711571157115711571157115711571157115711571157115711571157115711571157115711571157
1086108610861086108610861086108610861086108610861086108610861086108610861086108610861086
1047104710471047104710471047104710471047104710471047104710471047104710471047104710471047 1038
103810381038103810381038103810381038103810381038103810381038103810381038103810381038
960960960960960960960960960960960960960960960960960960960960960960908908908908908908908908908908908908908908908908908908908908908908 835
835835835835835835835835835835835835835835835835835835835835835
798798798798798798798798798798798798798798798798798798798798798798
729729729729729729729729729729729729729729729729729729729729729729
698698698698698698698698698698698698698698698698698698698698698698 627627627627627627627627627627627627627627627627627627627627627627 615
615615615615615615615615615615615615615615615615615615615615615577577577577577577577577577577577577577577577577577577577577577577
532532532532532532532532532532532532532532532532532532532532532532482482482482482482482482482482482482482482482482482482482482482482
Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700
%Tr
ansm
ittan
ce
40
48
56
64
72
1576157615761576157615761576157615761576157615761576157615761576157615761576157615761576
1543154315431543154315431543154315431543154315431543154315431543154315431543154315431543 1500
1500150015001500150015001500150015001500150015001500150015001500150015001500150015001462146214621462146214621462146214621462146214621462146214621462146214621462146214621462 1435
143514351435143514351435143514351435143514351435143514351435143514351435143514351435
1416141614161416141614161416141614161416141614161416141614161416141614161416141614161416
1379137913791379137913791379137913791379137913791379137913791379137913791379137913791379
1346134613461346134613461346134613461346134613461346134613461346134613461346134613461346
1294129412941294129412941294129412941294129412941294129412941294129412941294129412941294 1261
126112611261126112611261126112611261126112611261126112611261126112611261126112611261
1236123612361236123612361236123612361236123612361236123612361236123612361236123612361236
1203120312031203120312031203120312031203120312031203120312031203120312031203120312031203 1157
115711571157115711571157115711571157115711571157115711571157115711571157115711571157
1146114611461146114611461146114611461146114611461146114611461146114611461146114611461146
1109110911091109110911091109110911091109110911091109110911091109110911091109110911091109
1086108610861086108610861086108610861086108610861086108610861086108610861086108610861086
1047104710471047104710471047104710471047104710471047104710471047104710471047104710471047 1038
103810381038103810381038103810381038103810381038103810381038103810381038103810381038
960960960960960960960960960960960960960960960960960960960960960960
931931931931931931931931931931931931931931931931931931931931931931 908
908908908908908908908908908908908908908908908908908908908908908850850850850850850850850850850850850850850850850850850850850850850 835
835835835835835835835835835835835835835835835835835835835835835
798798798798798798798798798798798798798798798798798798798798798798
783783783783783783783783783783783783783783783783783783783783783783
729729729729729729729729729729729729729729729729729729729729729729
698698698698698698698698698698698698698698698698698698698698698698648648648648648648648648648648648648648648648648648648648648648648 627
627627627627627627627627627627627627627627627627627627627627627 615
615615615615615615615615615615615615615615615615615615615615615
588588588588588588588588588588588588588588588588588588588588588588
577577577577577577577577577577577577577577577577577577577577577577
532532532532532532532532532532532532532532532532532532532532532532 513
513513513513513513513513513513513513513513513513513513513513513
482482482482482482482482482482482482482482482482482482482482482482
451451451451451451451451451451451451451451451451451451451451451451444444444444444444444444444444444444444444444444444444444444444444
417417417417417417417417417417417417417417417417417417417417417417
4-Hydroxy-MIPTThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 5 of 5SWGDRUG.org/monographs.htmLatest Revision: 2/5/2015
http://en.wikipedia.org/wiki/4-HO-MiPT
4. ADDITIONAL RESOURCES
Wikipedia