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APPLICATION FORM

YSP-Travel Fellowships for 13th FAOBMB Congress, Bangkok, 23-29 November, 2012.

Name of Applicant: Mr. Jia-Hua Feng (also known as Kyaw Minn Hsan) Position: Ph.D. Student (4th year Ph.D. student at Institute of Plant Biology, National

Taiwan University, Taiwan) Address of Applicant: Agricultural Biotechnology Research Center, Academia Sinica Agricultural Technology Building (Room A728), No. 128,

Sec. 2, Academia Road, Nankang, Taipei 11529, Taiwan Email address: [email protected] Membership of FAOBMB Constituent Society: Taiwan Society for Biochemistry

and Molecular Biology Date of Birth: 26/10/1978 Proof of Age: I certify on the basis of official documentation which I have seen (e.g. passport, birth certificate or driver’s licence) that the date of birth of the applicant Mr. Jia-Hua Feng is 26/10/1978, as shown above. Signed: Lie-Fen Shyur Position: Deputy Director of Agricultural Biotechnology Research Center, Academia

Sinica, Taiwan Have you previously received an FAOBMB Travel Fellowship? If yes, please indicate when. No, I have not received an FAOBMB Travel Fellowship previously.

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CURRICULUM VITAE

PERSONAL INFORMATION:

Name: 馮家華 Jia-Hua Feng (also known as Kyaw Minn Hsan)

Date of Birth: Oct 26, 1978

Nationality: Myanmar

Gender and Status: Male, Married

Contact Number: +886-2-27872100

E-mail: [email protected]

Address: Agricultural Biotechnology Research Center, Academia Sinica.

Agricultural Technology Building (Room A728), No. 128, Sec. 2, Academia

Road, Nankang, Taipei 11529, Taiwan

EDUCATION:

2007 B.Sc. in Department of Life Science, National University Kaohsiung.

2009 M.Sc. in Institute of Biotechnology, National University Kaohsiung.

Research Theme: In vitro morphogenesis of Paphiopedilum &

Phalaenopsis orchids

2009 to date Ph.D. student in Institute of Plant Biology, National Taiwan University.

Research Theme: Chemopreventive effects of novel

phytochemicals for modulating inflammation and cutaneous

metastatic melanoma

AWARDS:

1. Outstanding students in orchid biotechnology scholarship

Collage of Science, National University Kaohsiung’s (2007, 2008)

2. Outstanding postgraduate overseas students scholarship

National Taiwan University (2011, 2012)

PROFESSIONAL ACTIVITY:

Member of Taiwan Society for Biochemistry and Molecular Biology

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PUBLICATIONS: 1. Kyaw-Minn Hsan, Chun-Chieh Chen, and Lie-Fen Shyur* (2010) Current

Research and Development of Chemotherapeutic Agents for Melanoma. (Review article) Cancers. 2(2):397-419. (IF not yet available) KM Hsan’s contribution to this work was writing the first part of the paper including (1) Introduction to Melanoma, (2) Current Chemotherapeutic Agents for Melanoma and (3). Targeted or Combination Therapies for Treatment of Melanoma. Moreover, Hsan reorganized the second part of the contents wrote by CC Chen and then combined the two parts together to complete the first draft of this review article.

2. Jia-Hua Feng, Tsui-Wei Chou, Sheng-Yang Wang, Chi-Chang Huang, Ya-Wen Cheng, and Lie-Fen Shyur* (2012) A kavalacton desmethoxyyangonin prevents inflammation and fulminant hepatic damage in mice. Manuscript in preparation (to be submitted). JH Feng contributes to the in vitro bioactivity study, data analysis and organization, and writing manuscript draft.

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ABSTRACT

A kavalacton desmethoxyyangonin prevents inflammation and fulminant hepatic

damage in mice

Jia-Hua Feng1,2, Tsui-Wei Chou3, Sheng-Yang Wang4, Chi-Chang Huang5, Ya-Wen

Cheng1, and Lie-Fen Shyur1,*

1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan 2 Institute of Plant Biology, National Taiwan University, Taipei, Taiwan 3 Department of Culinary Arts, Taoyuan Innovation Institute of Technology, Taoyuan

County, Taiwan 4 Department of Forestry, National Chung Hsin University, Taichung, Taiwan 5 Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan

County, Taiwan

The present study identified a kavalacton, namly desmethoxyyangonin (DMY), from

the rhizome of Alpinia pricei Hayata (Zingiberaceae) which is used as a folk medicine

for inflammation and various disorders. Various bioassays, such as LPS-induced

inflammation in murine RAW 264.7 macrophage cell model, LPS/D-GalN-induced

fulminant hepatitis in ICR mouse, and comparative metabolomics technology were

employed for elucidating the bioefficacy and underlying mechanisms of DMY in vitro

and in vivo. Our results showed that DMY significantly inhibited proinflammatory

mediators expressions, including IL-6, TNF-α, nitric oxide, and iNOS in LPS-

stimulated macrophages. No cytotoxicity was detected for DMY in hepatocytes.

LPS/D-GalN induced acute inflammation and hepatic damages in mice accompanied

with the increase of aminotransferases activities, F4/80 cells, leukocytes, and red

blood cells infiltrations in the liver tissues were effectively prevented by i.p. pre-

administration of DMY (1 mg/kg body weight) for three successive days before

LPS/D-GalN challenge. The results of hyphenated UPLC/ESI-QTOF mass

spectrometry and partial least-squares–discriminant analysis (PLS-DA) showed that

the overall primary metabolomic profile in the fulminant hepatic damaged mice is

more distinct to that of vehicle control or DMY-treated mice. Mechanistic

investigations demonstrated that DMY protects LPS or LPS/D-GalN induced damages

in cell or animal tissues mainly through de-regulating phosphorylation of IKK/IB

and Jak2/STAT3 signalling pathway. This article is for the first time to elucidate the

novel bioactivity of DMY, and the results suggest that DMY may be valuable for

further development into an agent for inflammatory disorders.

Keywords: Alpinia pricei Hayata, desmethoxyyangonin, anti-inflammation, fulminant

hepatitis, comparative metabolomics, JAK-2/STAT3 signalling pathway.

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PERSONAL STATEMENT Research Interests I have a broad range of research interests. I am interested in 1) plant tissue culture, 2) phytoremediation, 3) molecular mechanism of plant innate immunity, and 4) molecular mechanism of Traditional Chinese Medicine (TCM) against human diseases. Especially, I am eager to know why some plants can be used as folk medicine for thousand years of human experiences, and what scientific evidences which we can provide to support their usages. So, I’m currently conducted in studying the isolation of bioactive phytocompounds from medicinal herbal plants, in vitro cell and gene based assays, and in vivo animal model for validation of bioefficacy and shedding lights on mechanistic insights of target phytoagents under the supervision of Dr. Lie-Fen Shyur, Research Fellow/Deputy Director of Agricultural Biotechnology Research Center, Academia Sinica, Taiwan. Career Goals My career goal is to be a principle investigator in Myanmar if I have an opportunity to go back to there as a researcher. I want to teach and educate young people in Myanmar about whatever I have learned in Taiwan as a kind of contribution to my native land. The Reasons to Participate in the YSP Program As a Ph.D. student and research people, I must know the most recent scientific knowledge and information around the world. Also, it is very important that I can share and communicate my research works and results in the conferences with the worldwide scientists to gain important suggestions, critics and comments from them. In turn, my research can be improved. So, I hope to have a chance to present my research and to exchange knowledge and/or opinion with the meeting participants. Most importantly, I am eager to get familiar with young scientists from FAOBMB regions and conferences in order to cooperate with them in the near future.

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