2nd annual virtual conference - acsbiot.org

ACS BIOT National Meeting Fall 2021

2nd Annual Virtual Conference

Atlanta, Georgia August 22-26th, 2021

2 Virtual National Meeting 2021ACS BIOT

Program Grid..........................................................................pg. 3

Company Sponsors...........................................................................pg. 7

Non-Technical BIOT Meetings...............................................................................pg. 9

Keynote Speakers.........................................................................................pg. 10

Virtual Reception & Networking Session................................pg. 12

Award Winners..................................................................pg. 13

BIOT Tank.........................................................................pg. 21

Company Seminars................................................................pg. 22

BIOT DIvision Business and Programming Meeting.............................pg. 23

How to Combat Implicit Biases in Organizations.............................................pg. 27

ESBES Design Competition.........................................................pg. 29

ESBES CompetitionNetworking........................................pg. 30

Networking/Mentoring Session.......................................pg. 31

Table of Contents

3 Virtual National Meeting 2020

Sunday 8/22 Monday 8/23 Tuesday 8/24 Wednesday 8/25

N/A N/A930-1025: Business/Future

Programming930-1025: Breakfast of Champions:

Inscripta

Advances in Chromatographic Separations for mAbs

Non-Chromatography Based Separation of Biomolecules: mAbs

Case Studies in Tech Transfer, Scaleup, & Integrated Process Design

(Keynote)

Advances in Process Analytical Technologies for Measurement &

Control

Advances in Protein Engineering 1Microbial Metabolic Engineering:

Bacterial HostsNew Biomolecular Tools for

Microbial Metabolic EngineeringProcess Development and Reactor

Engineering

Novel approaches to diagnose and study disease

Advances in Protein Engineering 2 (Keynote)

Protein Structure & FunctionChallenges in Developing Novel

Modalities

N/A N/ANew Technologies in Cell &

Microbiome Engineering and Stem Cell Therapy

Big Data in Discovery & Development of Biopharmaceuticals (Keynote)

N/A Lunch and Learn: Cytiva Lunch and Learn: Bio Rad Lunch and Learn: 3MLunch and Learn:

Thermo

Van Lanen Service Award; Young Investigator Award Talk

Peterson Award; Marvin J. Johnson Award Talk

Young Professionals Award; Alan S. Michaels Award Talk

How to Combat Implicit Biases in Organizations

N/A

Advances in Chromatographic Separations beyond mAbs 1

Non-Chromatography Based Separation of Biomolecules

Membrane-Based Downstream Bioprocessing

Downstream Processing of Non-Antibody Modalities; session A

Enzyme Engineering & BiocatalysisMicrobial Metabolic Engineering:

Eukaryotic HostsHigh-Throughput Screening &

AutomationSynthetic Biology & Genome

Engineering

Unique Metamaterials for Imaging and Diagnostics Applications

New Technologies for the Delivery & Targeting of Therapeutics (Keynote)

Advances in Process Development & Manufacturing of Biologic Drug

Products

Biotechnology & Bioengineering Awards: Wang: Benjamin Woolston

and Gaden: Andre Palmer

N/A N/ACOVID Vaccines - From Discovery to the Fastest Vaccine Development in

History (Keynote)N/A

N/A N/A N/A N/A

Advances in Chromatographic Separations beyond mAbs 2

Membrane-Based Downstream Bioprocessing

In Silico & Mechanistic Modeling of Downstream Bioseparations

Downstream Processing of Non-Antibody Modalities

Systems Biology & Omics-Tools & Applications

Engineering Microbial Communities & Non-Model Systems (Keynote)

Advances in Cell Culture Media and Novel Modalities (Keynote)

Advances in Integrated Unit Operations Automation, Control and

PAT

Protein Engineering Application in Therapeutics, Diagnostics & Sensors

Biosensors & Probes for Medical Diagnostics

Protein Developability, Physical and Chemical Stability

Cell and Gene Therapy: Development & Manufacturing of Cell Therapy

Products (Keynote)

N/A N/ACOVID Therapeutics - From Discovery

to Super-Accelerated CMC Development

N/A

N/A N/A N/A N/A

In Silico & Mechanistic Modeling of Downstream Bioseparations

Protein Aggregation & Immunogenicity

COVID-19 Diagnostics & Detection - Technologies, Challenges & the Scale-

Up of Testing

Synthetic Biology & Genome Engineering

Big Data Biomedical Biomolecular & Biophysical Processes

Cell and Gene Therapy

Downstream ProcessingIntegrated and Continuous

ProcessingProtein Engineering Upstream Processing

Award Talks Other events

All times EDT

Student Networking (7-8:30)

Cell and Gene Therapy Session IV: Lentiviral Vector Focus

Integrated and Continuous Upstream and Downstream Processing (Keynote)

Inter-Molecular and Protein Interactions

N/A

Cell and Gene Therapy: AAV Focus

Implementation: It's Happening! (Keynote)

Formulation Strategies & Novel Routes of Administration

N/A

ESBES competition networking

Thursday 8/26

David Perlman Award Talk BIOT Reception

Posters

N/A

8:00-10:00 AM

12:30-1:15 PM

1:20-2:00 PM

4:00-4:30 PM

COVID

BIOT Tank( 7-8)

N/A

Downstream Processing of Novel Antibody Structures and Other

Modalities

Emerging Biophysical & Analytical Characterization Technologies

(Keynote)

Cell and Gene Therapy: T Cell Focus (Keynote)

ESBES Design Competition

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BIOT Events ACS Events

https://www.acsbiot.org/index.php/home-new

https://acs.digitellinc.com/acs/live/21/page/411/1?eventSearchInput=&eventSearchTrack%5B%5D=260

Virtual National Meeting 2021ACS BIOT 4

Dear Colleagues, On behalf of the BIOT Executive Committee, I would like to welcome you to the 2021 ACS National Meeting. Our Program Chairs Caryn Heldt (Michigan Technological University) and Aaron Noyes (Codiak Biosciences) have done an outstanding job leading the efforts to organize this year’s BIOT program. While it was our sincere hope that this year’s annual meeting could be held in person, the continued impact of the pandemic around the world made a virtual meeting the only prudent option. However, we are excited about this year’s virtual program, made possible by the thoughtful planning of our program chairs, assisted by area coordinators, session chairs, long-term program coordinator Scott Banta, and many other volunteers. This year’s exciting program includes four award lectures, thirteen keynote lectures, and over 350 oral and poster presentations, across nine program areas, including Upstream Processes, Downstream Processes, Biomolecular Technologies, Biomedical Technologies, Big Data, Cell and Gene Therapy, Integrated and Continuous Processing, Protein Engineering and COVID-19. The BIOT Tank, which celebrates the entrepreneurial side of BIOT, is back for its fourth year on Monday. The ESBES-BIOT Student Biotech Design Competition also returns, and we encourage all of you to attend for the final presentation of the student design cases. In addition to the technical program, our chairs and volunteers have organized many opportunities for networking, mentoring, supporting and building community amongst our members. The ACS BIOT Division is truly interdisciplinary, with members coming from different sectors and around the globe. We remain committed to the mission of BIOT, which is to enable a diverse and inclusive community of biotechnology professionals, innovations and solutions by being the “go-to” global resource for information exchange and dialogue across academia, industry, and government. Member volunteers are the heart and workforce of all BIOT endeavors. If you are interested in contributing to the next ACS annual meeting as a Program Chair, Area Coordinator or Session Chair, please attend the future programming/BIOT business meeting on Tuesday, August 24 at 9:30 am EDT. This division is built by volunteers, and we are always looking to grow our community. Please do not hesitate to contact me, or any other members of the BIOT Executive Committee to learn more about volunteer opportunities. I would also like to acknowledge all of the BIOT Executive Committee members for their work to make BIOT a valuable organization: Past-Chair Cynthia Collins, Chair-Elect Varnika Roy, Secretary Nihal Tugcu, Treasurer Venkatesh Natarajan, Communications Coordinator Varnika Roy, Awards Chair Matthew Lazzara, Membership Chair Yonghyun (John) Kim, Webmaster Mark Blenner, Councilors Arindam Bose, Jim Neville, Cynthia Collins, and David Roush, and Alternate Councilors William Kelly, Aaron Noyes, Raquel Orozco and Todd Przybycien. I hope to see you at the virtual meeting. Please join me in thanking the presenters and organizers and our industrial sponsors for making this meeting another excellent opportunity for networking and exchange of ideas. I hope you enjoy the meeting! Sincerely,

Anne Kantardjieff 2021 BIOT Division Chair


Acknowledgment from the Program Chairs

Dear BIOT Members:

Welcome to ACS BIOT’s second virtual conference! We have learned a lot over the past year about what a good virtual conference looks like and we tried to incorporate as many of these features as possible.

This year’s technical program will be available on the ACS website with links to all of the BIOT content in our Guidebook app. Most talks will be delivered live over Zoom, with a few that are pre-recorded due to scheduling conflicts. We opted for more concentrated areas this year so the program has nine smaller areas, plus posters. To the four traditional areas of Biomedical Technologies, Biomolecular and Biophysical Processes, Downstream Processes, Upstream Processes, we added Big Data, Cell and Gene Therapy, COVID Vaccine, Therapies, and Diagnostics, Integrated and Continuous Processing, and Protein Engineer-ing. Keynote talks are dispersed throughout the program and can be found in the Theme section of the Guidebook app. We are also looking forward to a rich poster session on Wednesday evening.

BIOT is also sponsoring several events during the week of August 22-26 which will require BIOT member-ship and can be found in the Guidebook app and on the BIOT website (www.acsbiot.org). All times are PM EDT except where note:

• Award talks from 1:20-2:00 Sunday through Tuesday• BIOT Tank (Shark Tank-like event) from 7-8 Monday• Student networking event from 7-8:30 Thursday• Lunch and Learns from 12:30-1:15 and Breakfast of Champions from 9:30-10:25 AM Monday through Thursday• Workshop on Combating Implicit Bias (1:20-2:00) Thursday• Joint BIOT/ESBES Design Competition and Networking

The Sunday reception (7-9pm on 8/22) will be hosted through Gatherly, an online networking platform. We hope you enjoy exploring all that it has to offer. We will have a keynote talk by the Perlman awardee, Dr.Peter Marks from FDA CBER. We will have a virtual escape room and other fun activities to help bring our vibrant community together. The evening will rap up with a raffle of prizes and a sign up for some great BIOT swag. Come join the fun!

We are extremely grateful for the support and assistance of numerous individuals and sponsors. Program planning would not have been possible without the dedicated efforts of an excellent team of area coordina-tors, session chairs, executive committee members, and ACS and BIOT support staff, particularly Brandi Rubino. Financial support from corporate sponsors was also critical to our ability to host a first-rate meeting packed with keynotes, award lectures, networking and other events. These individuals and sponsors are highlighted in greater detail in the acknowledgment pages and throughout the program book, as well as in the Guidebook app and in introduction slides for the technical sessions.

We trust you will enjoy all that this year’s program has to offer. We thank you for entrusting the event to our leadership and look forward to connecting with you during the meeting.

Best regards,Caryn Heldt, Michigan Technological UniversityAaron Noyes, Codiak BioSciencesCo-chairs ACS BIOT 2021


AcknowledgmentsWe are extremely grateful to the many wonderful volunteers who donated their time and talent to making

this meeting a success. In particular, we would like to acknowledge the efforts of a dedicated team of area coordinators who worked with session chairs to plan the meeting.

Upstream ProcessesOrganized by Melisa Carpio, Nitya Jacobs, Danielle Tullman-Ercek

Downstream ProcessesOrganized by Dan Bracewell Wai Keen Chung, Elizabeth Goodrich

Biomedical TechnologiesOrganized by John Kim, Maryam Raeeszadeh, ?? Sarmazdeh

Biomolecular & Biophysical TechnologiesOrganized by Cesar Calero, Maryam Raeeszadeh-Sarmazdeh, Krishna Mallela

Big DataOrganized by Sandeep Kumar, Jim Lalonde

Integrated Continuous ProcessingOrganized by Lars Pampel, Nihal Tugcu, Tim Tully

Cell and Gene TherapyOrganized by Bill Kelly, Nooshie Sanaie, Mercedes Segura

COVID Vaccine, Therapies, and Diagnostics/Pandemic ResponseOrganized by Frank Kotch, Varnika Roy, Shannon Servoss

Rapid Fire and Traditional Poster SessionOrganized by Kelsey O’Donnell, Kristen Vallente


Company Sponsorship 3M

AbbVieAstraZeneca

AvitideBio-Rad Laboratories

Biotechnology and BioengineeringCodiak BioSciences

CytivaDelaware Innovates

GenentechGlaxoSmithKline

InscriptaJSR Life Sciences

MilliporeSigmaMerck

ModernaNIIMBL

Novo NordiskPfizerSanofi

Thermo Fisher Scientific


Area Sponsorship

Special Thanks to Our Area Sponsors!

COVID Vaccine, Therapies, and Diagnostics Moderna

Upstream ProcessingPfizer

Downstream Processing 3M

Big Data Sanofi

Integrated and Continuous Processing MilliporeSigma

Cell and Gene Therapy Genentech


Sunday August 22, 2021

Van Lanen & Young Investigator Awards

1:20 PM EDT

Sunday Reception & David Perlman Award

7:00 PM EDT

Monday August 23, 2021

Lunch & Learn - Cytiva

12:30 PM EDT

Peterson & Marvin Johnson Awards

1:20 PM EDT

BIOT Tank

7:00 PM EDT

Tuesday August 24, 2021

BIOT Business Meeting/Future Programming

9:30 AM EDT

Lunch & Learn - Bio Rad

12:30 PM EDT

Young Professionals & Alan S. Michaels Award

1:20 PM EDT

Non-Technical BIOT MeetingsWednesday August 25, 2021

Breakfast of Champions - Inscripta

9:30 AM EDT

Lunch & Learn - 3M

12:30 PM EDT


1:20 PM EDT

B&B Gaden and Wang Awards

2:00 PM EDT

Poster Session

7:00 PM EDT

Thursday August 26, 2021

Lunch & Learn - Thermo Fisher Scientific

12:30 PM EDT

ESBES Design Competition

12:30 PM EDT

ESBES Competition Networking

4:00 PM EDT

Student Networking Session

7:00 PM EDT

https://american-chemical-society.zoom.com/j/87537692548?pwd=bjc3Q2JyS1hJZGtIUmNTV2hZVUJhUT09

https://biot2021.event.gatherly.io

https://american-chemical-society.zoom.com/webinar/register/WN_MXOgILDjSmWBmmZXsFxCJQ

https://american-chemical-society.zoom.com/j/88401850111?pwd=WnBkVVZoY2Z6dnB2TkMxQm9CTkJjUT09

https://us06web.zoom.us/j/81225671600?pwd=L0tFTGpZOFg3bDloQmk2RG01K1JpQT09

https://american-chemical-society.zoom.com/j/85759316514?pwd=YTI3aEZ0bzJjYis5Q2syTitqaWdldz09

https://us06web.zoom.us/webinar/register/WN_X4KW5AZFRbWkvYuragVclQ

https://us06web.zoom.us/j/89227112691?pwd=NEFlUGZseTVXQkxmQVlUWG5hbEMydz09

https://us06web.zoom.us/webinar/register/WN_DCV5HXVxRL-Ra4BpMh7eDg

https://us06web.zoom.us/webinar/register/WN_2iMaNxXsSHS5taR5FmF9uQ

https://us06web.zoom.us/j/86556737697?pwd=TTlNdHJBYXdSNC9ZeVlPdVZhU3A2QT09

https://acs.digitellinc.com/acs/live/21/page/411/1?eventSearchInput=biotechnology+and+bioengineering&eventSearchDate%5B%5D=2021-08-25&eventSearchTrack%5B%5D=260

https://acs.digitellinc.com/acs/live/21/page/411/1?eventSearchInput=&eventSearchTrack%5B%5D=260&eventSearchType%5B%5D=29

https://us06web.zoom.us/webinar/register/WN_k5UP9cSURla4o5T54ssnbQ

https://american-chemical-society.zoom.com/j/82452530772?pwd=M28yM0dYbUFOWlIxbHVqM2ZuSFZpUT09

https://us06web.zoom.us/j/84309095538?pwd=RUNNM2UxMzRBeGl5ejlndG9haXc4QT09

https://us06web.zoom.us/j/89502158559?pwd=SzhHaFZ5aGZKRENIR04zeVUrUHB0QT09


Keynote Speakers

Upstream ProcessesCarrie EckertRenewable and Sustainable Energy Institute (RASEI)Utilizing CRISPR-Cas toolkits for genotype-phenotype discovery and engineering of non-model microbes

Monday August 23rd, 4:30 PM EDT

Downstream ProcessesJorg Thommes Repertoire Immune MedicinesManufacturing innovation as a must to enabling accessibility and affordability of biologics

Tuesday August 24th, 10:30 AM EDT

Biomedical TechnologiesMillicent O. SullivanUniversity of DelawarePeptide-mediated growth factor gene therapy using extracellular matrix-inspired biomaterials

Monday August 23rd, 2:00 PM EDT

Protein EngineeringVesna MitchellCodexisEngineering of a robust, high-fidelity DNA polymerase for use in NGS library amplification

Monday August 23rd, 10:30 AM EDT

COVIDKizzmekia CorbettHarwardRapid development of COVID-19 mRNA vaccines

Tuesday August 24th, 2:00 PM EDT

Upstream ProcessesJunghae SuhBiogenGene therapy for neurological diseases



Downstream ProcessesKarol LackiAvitide, Inc.Is affinity all you need?

Wednesday August 25th, 2:00 PM EDT

Cell and Gene TherapyMelissa Bonner bluebird bioLentiviral vector gene therapy for sickle cell disease


Biomolecular and Biophysical ProcessesHanns-Christian MahlerBionterAnalytical and process development challenges and opportunities in cell and gene therapy

Wednesday August 25th, 10:30 AM EDT

Big DataGrant MurphyMerckEngineering novel proteins: Protein design, directed evolution, and machine learning

Wednesday August 25th, 10:30 AM EDT

Biomolecular and Biophysical ProcessesDavid KeireFDAPharmaceutical quality by the state of the art: Establishing new analytical protocols to assure the quality of biologics

Thursday August 26th, 10:30 AM EDT

Cell and Gene TherapyKevin Curran, MDMemorial Sloan Kettering Cancer CenterNext-generation CAR T cells in the clinic

Thursday August 26th, 10:30 AM EDT

Integrated and Continuous ProcessingJason WaltherSanofiImplementation of integrated continuous biomanufacturing across a product portfolio

Thursday August 26th, 2:40 PM EDT


Virtual Reception&

Perlman Award Lecture

Sunday August 22nd

7:00 - 9:00 PM EDT

Networking Games

Escape RoomCan You Make it Out In Time?

Free BIOT Garment to Attendees!

Peter Marks, MD, PhD

Click Here to Join!

Prizes!Oculus VR Headset

17inch Blackstone grillNespresso MachineWireless Headset$100 REI giftcard

Director, Center for Biologics Evaluation and Research, FDA

https://www.acsbiot.org/index.php/home-new


Dear Fellow BIOT Enthusiasts,

Welcome to the August 2021 Virtual Meeting!

This year we celebrate the research and professional service achievements of ten colleagues. These include the David Perlman Memorial Lecturer, Alan Michaels Awardee, Marvin J. Johnson Awardee in Microbial and Biochemical Technology, BIOT Young Investigator, James M. Van Lanen Distin-guished Service Award recipient, and the recipients of the William H. Peterson Student Presentation Awards and Young Professionals Award in Upstream and Downstream Processing selected from the August 2020 virtual meeting. We will also celebrate the Biotechnology & Bioengineering Elmer Gaden and D.I.C. Wang Awardees. Recipients are introduced in this program along with descriptions of the awards, brief biographical sketches, and titles of awards lectures where applicable. Dates and times of awards recognitions and lectures are listed in the meeting program.

The BIOT Division expresses its sincere gratitude to all awards sponsors: 3M (Young Professionals Award in Upstream and Downstream Processing), Bristol-Myers Squibb (Perlman Lecture), Pfizer (Johnson Award), and Genentech (Young Investigator Award). Without the generosity and continued support of these sponsors, our awards process would not be possible.

We are indebted to colleagues who served on awards selection committees. The process of evalu-ating nominations and selecting awardees from among our talented BIOT membership is not easy, and we are grateful for selection committee members’ dedicated service.

Finally, sincere thanks to all who nominated a colleague for an award. If you have not previously been engaged in the awards process, we strongly encourage you to become active in the next cycle – and to think broadly and inclusively as you encourage fellow BIOT members to participate. We anticipate providing details on the upcoming awards cycle soon. Please feel free to contact me ([email protected]) with questions or recommended improvements to the awards process and its reach.

Congratulations to all 2021 awardees!

Best wishes,Matthew Lazzara, BIOT Awards Chair


Van Lanen Service AwardSunday August 22nd, 1:20 PM EDT

Cynthia Collins, Ginkgo Bioworks

This award recognizes an individual for outstanding contributions to the ACS Division of Biochemical Technology through committed and sustained service. Dr. Collins is receiving this award in recognition of her past and continuing years of service and leadership to BIOT as Program Chair, Division Chair and Councilor.

From Winnipeg, Canada, Cynthia received her BS from the University of Toronto in Chemistry and Biochemistry and her PhD in Biochemistry and Molecular Biophysics from Caltech. Cynthia then spent twelve years as a professor at Rensselaer Polytechnic Institute in Troy, NY, where her group focused on using synthetic biology to engineering communication, coexistence, and collaboration between bacteria for multispecies bioprocessing and biosensing applications. Cynthia joined Ginkgo Bioworks’s Codebase team as a Program Director in February 2021.

BIOT Young Investigator AwardSunday August 22nd, 1:20 PM EDT

Domesticating Oleaginous Yeast for Biochemical Production from Low-Value and Waste Substrates.

Mark Blenner, University of Delaware

This award, sponsored by Genentech, recognizes an outstanding young contributor to the field of biochemical technology who is also an active participant in the BIOT Division programs. Professor Blenner is being honored for his work to develop oleaginous yeast systems for biochemical production from low value and waste substrates.

Dr. Blenner is an Associate Professor of Chemical & Biomolecular Engineering at the University of Delaware. Prior to that, he was the McQueen Quattlebaum Associate Professor of Chemical and Biomolecular Engineering at Clemson University. He received his PhD in Chemical Engineering from Columbia University in 2009 and completed three years of postdoctoral training as an American Heart Association Postdoctoral Fellow and an NIH NRSA Postdoctoral Fellow at Harvard Medical School and Children’s Hospital Boston. In addition to winning the 2021 ACS BIOT Young Investigator Award, Dr. Blenner has won the Presidential Early Career Award

for Scientists and Engineers (PECASE), the 2020 South Carolina Governor’s Young Scientist Award for Excellence in Scientific Research, the 2019 Clemson University Junior Researcher of the Year, and several Young Faculty Awards from DARPA, NIH, NASA and the Air Force. His research is broadly focused on engineering biomolecular and cellular systems for the production of fuels, chemicals, enzymes, biopharmaceuticals and biosensors. Recently his group has started to focus using multi-omics methods to improve engineered cell lines for the biomanufacturing setting.




David Perlman Memorial Award LectureSunday August 22nd, 7:00 PM EDT

Expediting the Development of Vaccines for Public Health Emergencies

Peter Marks, Director, Center for Biologics Evaluation and Research, U.S. FDA

The Perlman Lectureship, showcases compelling speakers with leading research programs of special interest to the BIOT community. Dr. Marks is being recognized for his contributions in advancing regulatory science and supporting vaccine development, production, and clinical testing.

Peter Marks received his graduate degree in cell and molecular biology and his medical degree at New York University and completed Internal Medicine residency and Hematology/Medical Oncology training at Brigham and Women’s Hospital in Boston. He has worked in academic settings teaching and caring for patients and in industry on drug development. He joined the FDA in 2012 as Deputy Center Director for CBER and became Center Director in January 2016.

Emerging infectious diseases can cause epidemics or pandemics, as the current global COVID-19 outbreak has well demonstrated. Rapidly responding to such outbreaks requires adequate public health capabilities including the ability to rapidly develop, evaluate, manufacture, and deploy adequate supplies of preventative vaccines. Challenges encoun-tered during the development of COVID-19 vaccines illustrate the critical nature of the supply chain and manufacturing, including the availability of adequate production facilities for drug substance and drug product. Looking toward the fu-ture, advanced manufacturing technologies applied to complex biologic products, such as vaccines, offer the promise of addressing such challenges both for epidemic and pandemic events. Moreover, the application of such technologies promises to advance the manufacturing of routine vaccines and other complex biologic products, both increasing avail-ability and reducing cost.

https://biot2021.event.gatherly.io


W.H. Peterson AwardMonday August 23rd, 1:20 PM EDT

The W.H. Peterson Award is granted each year by the Division of Biochemical Technology to student members who present outstanding research work in sessions sponsored by the division at ACS national meetings.

Best Poster Presentation

Xiaozhe Ding, a graduate student from Professor Viviana Gradinaru’s group at Caltech, is being honored for his presentation titled “Bioinspired design of adeno-associated viral capsids with expanded sizes,” at the 2020 ACS meeting.

Xiaozhe Ding is a sixth-year Ph.D. student in Bioengineering at Caltech, working with Dr. Viviana Gradinaru. Xiaozhe’s research focuses on applying structure-guided protein engineering to develop molecular tools for biomedicine. His graduate research aims to expand the carrying capacity of adeno-associated viral (AAV) vectors, a widely used gene therapy vector, through engineering the self-assembly pathway of the capsid. Xiaozhe earned his B.S. in Biological Sciences from Tsinghua University, Beijing. He performed undergraduate research in structural biology and protein engineering

in the labs of Dr. Haitao Li (Tsinghua), Dr. Michael Lin (Stanford), and Dr. Xiaodong Liu (Tsinghua).

Best Oral Presentation

Eric VanArsdale, a graduate student from Professor William Bentley’s group at the University of Maryland, is being honored for his presentation titled “Connecting biology to electronics through a redox communication network of tyrosine, tyrosinase, and eumelanin,” at the 2020 ACS meeting.

Eric VanArsdale is a sixth year Ph.D. student in the Fischell Department of Bioengineering at the University of Maryland working in that lab of Dr. William Bentley. His graduate research has focused on the use of redox-based synthetic biology and electrochemistry to access and control biological communication. These efforts include the use of electrochemistry to access biological signals,

“electrogenetic” control over gene circuits in microorganisms, and materials design for bidirectional information storage. He foresees his research being used in many fields, including biomanufacturing for coordinating metabolic activities and product formation, as well as in bioelectronic medical devices such as artificial organs or probiotic capsules that require user-controlled functionality. Eric previously earned his B.S. and M.S. in Bioengineering from the Pennsylvania State University where he researched core-shell lipid nanoparticle fabrication for cancer drug delivery in the lab of Dr. Sheereen Majd.




Marvin J. Johnson Award in Microbial and Biochemical TechnologyMonday August 23rd, 1:20 PM EDT

Harnessing synthetic biology to fight pathogens

James Collins, MIT

The Johnson award, sponsored by Pfizer, Inc., is given in recognition of outstanding research contributions to microbial and biochemical technology. Professor Collins is being recognized for his pioneering contributions to synthetic biology, which have led to breakthrough advances in microbial and biochemical technology.

Jim Collins is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT, as well as a Member of the Harvard-MIT Health Sciences & Technology Faculty. He is also a Core Founding Faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University, and an Institute Member of the Broad Institute of MIT and Harvard. He is one of the founders of the field of synthetic biology, and his research group is currently focused on using synthetic biology to create next-generation diagnostics and therapeutics. Professor Collins’ patented technologies have been licensed by over 25 biotech, pharma and medical devices companies, and he has co-founded a number of companies, including Synlogic, Senti Biosciences, and Sherlock Biosciences, as well as Phare Bio, a non-profit focused on AI-driven antibiotic discovery. He has received numerous awards and honors, including a Rhodes Scholarship and a MacArthur “Genius”

Award, and he is an elected member of all three national academies - the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine.



Award for Young Professionals in Upstream and Downstream ProcessingTuesday August 24th, 1:20 PM EDT

Michael McGarrah, Merck

This award, sponsored by 3M, recognizes professionals 35 years of age or younger who present outstanding research or development work in the BIOT division poster session at the prior ACS national meeting. Michael McGarrah, Senior Scientist at Merck, is receiving the award for his presentation “Small scale modeling of disk stack centrifugation with mammalian cell culture capillary shear for a more predictive harvest process transfer” at the 2020 ACS meeting.

Michael McGarrah received a B.S. in Chemical Engineering from Bucknell University in 2014. After completing his undergraduate studies, Michael joined the harvest process development team in the Biopharmaceutical Downstream Process Development department at GlaxoSmithKline.

He specialized in early and late phase process development and clinical manufacturing technology transfer for centrifugation and filtration unit operations for several monoclonal antibody molecules. While at GlaxoSmithKline, he also attended Villanova University part-time and completed his M.S. in Biochemical Engineering in 2019. In 2021, Michael joined the Vaccine Process Development and

Commercialization department at Merck and is excited to gain expertise in a new area of pharmaceutical development.

Quality and Quantity?: Enhancing Mammalian Biomanufacturing Performance through Systems Biotechnology Approaches

Alan S. Michaels Award in the Recovery of Biological Products


A rather stochastic approach to chromatographic bioseparations

Richard Willson, University of Houston

This award, sponsored by the Recovery of Biological Products Conference Series, recognizes outstanding research and practice contributions towards the advancement of science and technology for the recovery of biological products. Dr. Willson is being recognized for advancing methods including mutagenesis, phage display, calorimetry, electrostatic modeling, single-molecule imaging, and nucleic acid separations.

Dr. Richard Willson is Huffington-Woestemeyer Professor of Chemical Engineering and Biochemistry at the University of Houston. He holds B.S. (honors) and M.S. degrees in Chemical Engineering from Caltech, and completed his Ph.D. in Biochemical Engineering (C.L. Cooney, R.C. Reid) and postdoctoral studies in Biochemistry (J. King) at MIT. Dr. Willson is the recipient of the Presidential Young Investigator Award, and a Fellow of the AAAS, NAI, AIMBE and ACS. He served as President of the International Society for Molecular Recognition, and as Program Co-Chair and Division Chair of ACS BIOT. He’s had many wonderful students and collaborators.




Biotechnology & Bioengineering Elmer Gaden Award LectureWednesday August 25th, 2:00 PM EDT

Engineering simple purification systems to generate a novel dual-functioning therapeutic complex for treatment of hemolytic conditions: the apohemoglobin-haptoglobin complex

Andre Palmer, Ohio State University

This award was established by John Wiley & Sons, Inc. and the journal Biotechnology & Bioengineering in honor of its founding editor Elmer Gaden, Jr., and recognizes a high-impact paper reflecting exceptional innovation, creativity and originality as well as career achievement. The award is presented annually at the ACS national meeting at a session of the BIOT Division. This year, Professor Andre Palmer is being recognized for his paper “Novel manufacturing method for producing apohemoglobin and its biophysical properties,” by Ivan S. Pires, Donald A. Belcher, Richard Hickey, Colbert Miller, Abraham K. Badu-Tawiah, Jin Hyen Baek, Paul W. Buehler, and Andre F. Palmer, Biotechnology and Bioengineering 117:125-145, 2020.

Professor Palmer’s research interests encompass the development of novel hemoglobin-based oxygen carriers for a variety of applications in transfusion medicine as red blood cell substitutes and tissue engineering as oxygen-carrying perfusates. His lab is also developing scavengers of hemoglobin, heme and iron, non heme-based plasma substitutes, and monocyte/macrophage targeted drug delivery systems. He is author of more than 146 peer reviewed publications. Among others, he received the 2021 Lumley Interdisciplinary Research Award from The Ohio State University College of Engineering and the National Science Foundation Career Award in 2001. Prof. Palmer

currently serves on the International Scientific Advisory Committee on Blood Substitutes, and is a member of the Bioengineering, Technology, and Surgical Sciences Study Section at the National Institutes of Health. He served as department chair from 2014-2019. In 2015, he was inducted into the College of Fellows of the American Institute for Medical and Biological Engineering. Palmer’s research is supported by grants from the National Institutes of Health and the Department of Defense.



Benjamin Woolston, Northeastern University

The B&B Daniel I.C. Wang Award was initiated in 2008 to honor a younger member of our dynamic community who has published in Biotechnology & Bioengineering within the last three years and is presented annually at the national ACS meeting at a session of the BIOT division. This year’s awardee is Professor Benjamin Woolston. Dr. Woolston joined the NEU Chemical Engineering department as an Assistant Professor in January 2020. As an NSF Graduate Research Fellow, Dr. Woolston received his PhD in Chemical Engineering in 2017 from MIT under the guidance of Prof. Greg Stephanopoulos, where his research

focused on the development of genetic tools to enable metabolic engineering in anaerobic CO2-fixing microbes, and the establishment of a methanol utilization pathway in the model organism Escherichia coli. While at MIT, he was an inaugural Fellow of the Chemical Engineering Communication Lab, where he provided peer tutoring and department-wide workshops to assist students and post-docs with aspects of scientific communication. His Post-doctoral work was conducted in the laboratory of Prof. Emily Balskus in the Chemistry & Chemical Biology department at Harvard University, where he studied microbial metabolic pathways and enzymes that contribute to the stability of health-associated Lactobacilli in the human vaginal microbiota. At Northeastern, his research program combines approaches from his previous research training in metabolic engineering, synthetic biology, biochemistry and microbiology to engineer microbes for biofuel & biochemical production, and as diagnostics and therapeutics in the human gut microbiota.

Establishing Eubacterium limosum as a model methylotrophic acetogen

Biotechnology & Bioengineering Wang Award




The Startups Face the Sharks at 7:00 PM EDT August 23rd

Tune in to vote for the ‘Audience Choice Award’ $1000

Sharks will also invest $5,000

Meet the Start-Ups

Skroot Labs

Karios Technologies

Nitro Biosciences

Meet the Sharks!

Dr. William ProvinePresident/CEO Delaware Innovation

Space

Prof. Steven CramerRensselaer Polytechnic Institute

Dr. Jonathan CoffmanAstraZeneca

Click here to Join!

https://us06web.zoom.us/j/81225671600?pwd=L0tFTGpZOFg3bDloQmk2RG01K1JpQT09


Lunch* and Learn

Innovations in downstream processing bring opportunity, but they also bring questions. When is fiber chromatography a better option than resin-based technology? How can we deal with the increasing diversity in target structures? And what is the potential for tailor-made ligands for molecules?

In this presentation, we help you answer such questions by discussing recent developments and potential future states of antibody purification platforms.

The last few years have seen a shift in antibody therapeutics toward more targeted patient populations and a more diverse antibody modality pipeline, with bispecific antibodies, antibody fragments, antibody–drug conjugates, and more. As a result, batch sizes are smaller, and bioprocessing is becoming more flexible and modular.

Fortunately, downstream processing continues to develop rapidly. New innovations in ligand and base matrix technology have the potential to boost the productivity, reliability, and applicability of antibody purification platforms and toolbox approaches. This presentation will help illuminate the benefits and limitations of these emerging technologies.

Recent and future development of antibody purification platforms

John Jenco PhD, Senior Bioprocess Application Scientist

Monday, August 23rd

12:30 - 1:15 PM EDT

Dr. John Jenco leads Pilot Plant and the Large-Scale Applications Group at Cytiva’s headquarters in Marlborough, MA. His team provides chromatography support for Cytiva’s clinical and full-scale biopharmaceutical manufacturing customers. He has 40 years of experience in chromatography and downstream processing, including analytical and preparative techniques at bench, pilot, and manufacturing scales for a wide variety of biomolecules. John received his B.S. in Biology from Loyola University of Chicago, and his Ph.D. in Molecular and Cellular Pharmacology from the State University of New York at Stony Brook.

Click Here to Register!!!

*Attendees will receive $20 gift cards to enjoy lunch at their convenience (qty = 100)*Attendees will receive $20 gift cards to enjoy lunch at their convenience (qty = 100)

https://american-chemical-society.zoom.com/webinar/register/WN_MXOgILDjSmWBmmZXsFxCJQ


Division Business MeetingTuesday, August 24th

All BIOT Members Welcome

Click Here to Join!

9:30 AM EDT

https://american-chemical-society.zoom.com/j/85759316514?pwd=YTI3aEZ0bzJjYis5Q2syTitqaWdldz09


Lunch* and Learn

Dr. Xuemei He is the R&D Manager of Chromatography Media Chemistry at Bio-Rad Laboratories. She earned her PhD in Biological Chemistry and has over 20 years of experience in biomolecule separation and characterization. Her laboratory is concentrated on the development of chromatography media for process-scale production of biopharmaceuticals, with an emphasis on the removal of residual process- and product-related impurities during polishing stage and viral safety.

• Understand the interactions between chromatography resins and biomolecules

• Develop effective purification methods

• Examine case studies for product related impurity removal- dimers, aggregates, and charge variants

Chromatography Strategies for the Removal of Product-Related Impurities

William Rushton, MS, Chromatography, Support Scientist, Process Chromatography

Xuemei He, Ph.D, R&D Manager, Media Chemistry, Process Chromatography

Tuesday, August 24th

12:30 - 1:15 PM EDT

William Rushton is a Process Chromatography Support Scientist for customer support and method development at Bio-Rad Laboratories in North America. William has over 23 years of industry experience in Downstream Process Development. Prior to Bio-Rad, he worked at Centocor, Auxilium Pharmaceuticals, and Charles River. He obtained a M.S in Biomedical Sciences from Philadelphia College of Osteopathic Medicine and his B.S in Biology from St. Joseph’s University.

Click Here to Register!!!!


https://us06web.zoom.us/webinar/register/WN_X4KW5AZFRbWkvYuragVclQ


Breakfast* of Champions

Heterologous protein production is an indispensable tool in biotechnology and biopharma for manufacturing enzymes, protein therapeutics, and more. Generating robust production strains involves strategies that target the protein itself as well as the host genome. Despite advances in strain engineering, optimization of protein production is still limited by the ability to access the broad sequence space, constrained by traditional, low-throughput, and laborious methods like promoter substitutions or random mutagenesis. Here we use a genome-wide, multiplexed, targeted editing approach that can generate diverse edit types in both the heterologous gene and across the host genome to optimize production of cellobiohydrolase I enzyme (CHB1) in S. cerevisiae. The edits conferring improved CBH1 expression span cellular processes Important for protein production, including transcription, translation, secretion, and protein degradation pathways. Learning Objectives:

• Demonstrate that host genome engineering is essential to heterologous protein production improvement• Utilize targeted approach to significantly shorten the strain development cycle• Use of trackable cell libraries enables discovery of new targets• Show that edits essential to protein production span multiple pathways: transcription, translation, secretion and

protein degradation

Improving heterologous protein production in yeast with massively parallel CRISPR genome editing

Eric Abbate, Director, Analytical Biochemistry, Applications Development

Wednesday, August 25th

9:30 - 10:25 AM EDT

Dr. Eric Abbate serves as the Director of Analytical Biochemistry on the Applications Development team. His work primarily focuses on developing and utilizing high-throughput phenotyping workflows to screen libraries generated using the Onyx platform. Eric’s academic background is in protein structure/function and worked for many years developing enzymes for industrial use at Novozymes prior to joining Inscripta.



https://us06web.zoom.us/webinar/register/WN_DCV5HXVxRL-Ra4BpMh7eDg


Lunch* and Learn

In this virtual lunch and learn seminar, we will explore how novel bioprocessing solutions, based on advanced materials and ligand chemistries, will help enable new bioprocessing strategies to address critical challenges in process simplification and intensification. Specifically, we demonstrate how im-plementing chromatographic separation straight out of the cell culture reactor blurs the line between clarification and purification. This, combined with advanced single use polishing chromatography solution will enable highly intensified and robust biopharmaceutical purification processes of the future.

Novel Chromatographic Single Use Platform for Promoting Process Simplification and Intensification

David Chau, PhD, Application Engineer Specialist

Wednesday, August 25th

12:30 - 1:15 PM EDT



https://us06web.zoom.us/webinar/register/WN_2iMaNxXsSHS5taR5FmF9uQ



Workshop summary:

Research shows that diverse and inclusive teams make better decisions and are more innovative compared to homogeneous teams. Research also shows that the average individual possesses implicit biases which can lead to microaggressions (behaviors and speech that offend people dif-ferent from them through non-conscious brain processes). A person who experiences one or more microaggressions in an organization does not feel included in that organization. To help organiza-tions reap the performance benefits of inclusivity and diversity, this workshop provides microinter-vention tactics to address microaggressions.

Information about the workshop’s professional facilitator:

Valerie Patrick is a PhD chemical engineer who worked in multi-national organizations for 25 years where she gained over 10,000 hours of experience leading teams to achieve a wide range of ob-jectives. Valerie founded Fulcrum Connection LLC in 2013 to provide instructional design, training, consulting, and facilitation for a broad range of topics related to teamwork, innovation, and sustain-ability. Valerie also has over 10,000 hours of experience as a Certified Professional Facilitator and is certified with distinction in the foundations of neuroleadership by the NeuroLeadership Institute. Valerie is author of When Bad Teams Happen to Good People: Your Complete Repair Guide for Successful Teamwork from Career Press (published in 2021).

Click Here to Join!

Wednesday, August 25th 1:20 - 2:00 PM EDT

https://us06web.zoom.us/j/86556737697?pwd=TTlNdHJBYXdSNC9ZeVlPdVZhU3A2QT09


Lunch* and Learn

Because current biopharmaceutical process development requires the use of living cell lines with highly specific nutritional and environmental needs, a number of complex challenges must be overcome. Among these is determining the optimal cell culture media formulation.

Successful media optimization depends on understanding data, specifically how each media component influences the cells. Traditionally, these data have been collected using a technique known as spent media analysis. However, the level of detail that can be obtained using spent media analysis is fundamentally restricted. This is true for both understanding the components themselves, as the technique only permits analysis of major metabolites such as glucose and amino acids, and how they are being used. This latter issue arises as the technique can only identify a limited number of the molecules which are taken up or secreted by the cells, rather than the global molecular changes including signaling and metabolic intracellular pathways the components are involved in. The only way to accelerate the development of next-generation biopharmaceuticals is to leverage next-generation analytical solutions.

This presentation will illustrate the considerable impact of applying a multi-omics analysis--utilizing proteomics and metabolomics--in obtaining a level of detail that is unparalleled in comparison to a spent media analysis approach. In particular, we will highlight how the extra level of granular intracellular detail can enable developers to either gain actionable results in less experimental iterations or, if not less iterations, gain better results from each iteration that they undertake—with the ultimate goal of making development and manufacturing more efficient and cost-effective.

Multi-Omics and Bioinformatics in Media Design:Unlocking cell line productivity through more precise media and feeds

Paul Gulde, PhD, Manager, Multi-Omics Research and Development

Chengjian Tu, PhD, Staff Scientist

Thursday, August 26th

12:30 - 1:15 PM EDT



https://us06web.zoom.us/webinar/register/WN_k5UP9cSURla4o5T54ssnbQ


ESBES Design Competition12:30PM EDT

Click Here to Join!

https://american-chemical-society.zoom.com/j/82452530772?pwd=M28yM0dYbUFOWlIxbHVqM2ZuSFZpUT09


ESBES Competition Networking2:00PM EDT

Click Here to Join!

https://us06web.zoom.us/j/84309095538?pwd=RUNNM2UxMzRBeGl5ejlndG9haXc4QT09


Thursday, August 26th

7:00 - 8:30 PM EDT

Meet fellow Members from Industry and Academia

Student Networking/Mentoring Session

Click Here to Join!

https://us06web.zoom.us/j/89502158559?pwd=SzhHaFZ5aGZKRENIR04zeVUrUHB0QT09


The ACS Biochemical Technology Division gratefully acknowledges the 2021 financial support provided by these biotechnology industry leaders.

Job # 21-0307 Trim Size 8.25 X 10.812

#ScienceForward

Accelerate your purification workflow development Did you know that Bio-Rad’s process chromatography resins are available in prepacked formats for high-throughput resin screening, method development, and optimization? The Foresight product family includes columns, RoboColumn Units, and 96-well filter plates prepacked with mixed-mode, ion exchange, or affinity resins. Foresight screening formats minimize sample and buffer requirements and facilitate parallel purification to improve conditions and expedite resin selection.

To learn more, visit bio-rad.com/ForesightTools

Speed up method development.Use our resin screening tools.

21-0307_PPB_Foresight_1B_Print_8.25x10.812_FINAL_TJ.indd 121-0307_PPB_Foresight_1B_Print_8.25x10.812_FINAL_TJ.indd 1 4/20/21 1:36 PM4/20/21 1:36 PM

Job # 21-0307 Trim Size 8.25 X 10.812

#ScienceForward

Accelerate your purification workflow development Did you know that Bio-Rad’s process chromatography resins are available in prepacked formats for high-throughput resin screening, method development, and optimization? The Foresight product family includes columns, RoboColumn Units, and 96-well filter plates prepacked with mixed-mode, ion exchange, or affinity resins. Foresight screening formats minimize sample and buffer requirements and facilitate parallel purification to improve conditions and expedite resin selection.

To learn more, visit bio-rad.com/ForesightTools

Speed up method development.Use our resin screening tools.

21-0307_PPB_Foresight_1B_Print_8.25x10.812_FINAL_TJ.indd 121-0307_PPB_Foresight_1B_Print_8.25x10.812_FINAL_TJ.indd 1 4/20/21 1:36 PM4/20/21 1:36 PM

Unprecedented scale• Build the largest massively

parallel, multiplexed libraries.• Make diverse edits including

insertions, deletions,substitution and more.

• Rapidly connect multipleexperiments, leveragingmachine learning processes.

Superior performance• High edit rates ensure your

designs are realized.• Barcode every cell,

track every edit.• Rational design approach

affords you precise control.

inscripta.com

Greater access• The Onyx workflow seamlessly

integrates software,consumables and instrumentinto a fully automated solutionthat requires minimalgene-editing expertise.

• Inscripta’s favorable licensingterms ensure that scientistsown their discoveries andsubsequent inventions.

Biofoundry on your benchtop.The Onyx™ Digital Genome Engineering Platform looks like nothing in your lab—because it IS like nothing in your lab. Now you can design, engineer, evaluate and track results, right on your benchtop.

Did you know Moderna is hiring for roles across CMC, including analytical development, manufacturing, process development and quality?Some roles include a $10K sign-on bonus and relocation.

CMC positions are in Norwood, MA at our state-of-the-art Moderna

Technology Center. MTC is an award-winning innovation hub

for manufacturing, technical development and digital excellence.

With 650,000 square feet of space, it is an integrated manufacturing

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at scale. Here, you can join a diverse, relentless team that deeply

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If you want to help turn innovation into impact,

find out more and apply at: modernacareers.com/norwood

The Modernaworld isexpanding.

Unprecedented scale• Build the largest massively

parallel, multiplexed libraries.• Make diverse edits including

insertions, deletions,substitution and more.

• Rapidly connect multipleexperiments, leveragingmachine learning processes.

Superior performance• High edit rates ensure your

designs are realized.• Barcode every cell,

track every edit.• Rational design approach

affords you precise control.

inscripta.com

Greater access• The Onyx workflow seamlessly

integrates software,consumables and instrumentinto a fully automated solutionthat requires minimalgene-editing expertise.

• Inscripta’s favorable licensingterms ensure that scientistsown their discoveries andsubsequent inventions.

Biofoundry on your benchtop.The Onyx™ Digital Genome Engineering Platform looks like nothing in your lab—because it IS like nothing in your lab. Now you can design, engineer, evaluate and track results, right on your benchtop.

90 state-of-the-art labs available across 130,000

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The Mobile Guide for theACS BIOT 2019 National Meeting

• Browse the technical program• Make a schedule• Take notes• Vote for Best of BIOT• Get live updates• Vote for ESBES Competition Winner• Contribute to Planning Future Meetings!

Download the Guidebook App from theApp Store and type BIOT2019 todownload the guide.

Twitter: @ACS_BIOT https://tinyurl.com/y33yfufu

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BIOT 2021

2021

@ACS_BIOT @ACSBIOT

2nd annual virtual conference - acsbiot.org

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