2015:20 the effects of mild, acute hypoxia on cognitive

Research

Report number: 2015:20 ISSN: 2000-0456Available at www.stralsakerhetsmyndigheten.se

The effects of mild, acute hypoxia on cognitive performance

2015:20

Authors: Martin CastorJonathan Borgvall

SSM 2015:20

SSM 2015:20

SSM perspective

Background The Swedish nuclear power plant Forsmarks Kraftgrupp AB (FKA) reported that they wanted to use a fi re prevention method by reducing the oxygen level down to 15% in some locations. The personnel is only going to work there for a limited number of hours. This fi re protection method has never been used before in any nuclear power plant in spaces where people work.

The background to the study was the lack of comparable, suffi ciently rel-evant scientifi c literature on the topic of whether cognitive ability dete-riorates or not when the oxygen (O2) level is reduced from the normal level (21%) to 15%, without habituation. SSM needed more knowledge of whether the cognitive abilities of the personnel could be aff ected in a negative way. The goal of the study was to provide SSM with the basis for oversight.

ObjectivesThe study was divided into two parts, a literature study and an experi-mental part. The phenomenon studied was comparable to the situation at the nuclear power plant. The persons involved in the experimental phase were exposed to a change from normal oxygen level to a reduced oxygen level without having time to adapt. The exposure to 15% oxygen was 2 h during the fi rst exposure, 2 h during the second exposure and 45 min during the third and fi nal exposure.

ResultsThe literature review primarily identifi ed evidence that the eff ects on cognitive performance due to hypoxia at 15% O2, if any, would be small. A few researchers have reported fi ndings that support adverse eff ects on cognitive performance already at 16-15% O2 concentration. In sup-port of the hypothesis that no adverse eff ects on cognitive performance could be observed under conditions studied, there were no signifi cant decreases in cognitive performance as a result of exposure to the experi-mental conditions with 15% O2.

This study was clearly delineated and several possible infl uencing aspects were not included. Therefore, we cannot rule out possible inter-action eff ects, with negative impact on cognitive ability, between hypoxia and other factors such as diseases, medication and drugs, concussion history, or other aspects of air quality.

Need for further researchThere are several aspects of this research that should be of interest for further research by the nuclear industry. SSM has no plans to fund fur-ther research.

Project informationContact person SSM: Yvonne JohanssonReference: SSM2013-5580

SSM 2015:20

2015:20

Authors:

Date: June 2015Report number: 2015:20 ISSN: 2000-0456Available at www.stralsakerhetsmyndigheten.se

Martin Castor, Jonathan Borgvall

GEISTT AB, Kista

The effects of mild, acute hypoxia on cognitive performance

SSM 2015:20

This report concerns a study which has been conducted for the Swedish Radiation Safety Authority, SSM. The conclusions and view-points presented in the report are those of the author/authors and do not necessarily coincide with those of the SSM.

SSM 2015:20

SSM 2015:20

Excluded (n=30), because:Did not meet inclusion criteria (n=2)

Could not participate (n=28)

Assessed for eligibility (n=48)

Enrolment(n=18)

Assignment(n=18)

Analysis(n= 17/18)

Assigned to experimental group and exposed to experimental manipulation (n=18)

Analyzed: n = 17 for ANAM; n = 18 for K-D test) Excluded: n = 1 on ANAM due to outlier data

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60

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90

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110

Hear

t rat

e (g

ray

line)

, bea

ts p

er m

inte

Oxyg

en sa

tura

tion

(dot

ted

line)

, % sa

tura

tion

Clock time

Arterial oxygen saturation and Heart rate for one participant from 9.40 to 12.00

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10

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70

5 6 7 8 9 10 11 12 13 14 15

Seco

nds (

s)

Occasion, with baseline testing (occasion #5), experimental exposure #1 (occasion #6 to #9), experimental exposure #2

(occasion #10 to #13), and experimental exposure #3 (occasion #14 and #15).

K-D test mean times for 18 participants over 11 test occasions, i.e., excluding training and

post-test

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2

3

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7

1 2 3 4 5 6 7 8 9 10

Fatig

ue ra

ting

Occasion

Mean fatigue ratings over ten rating occasions

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5

6

7

1 2 3 4 5 6 7 8 9 10

Disc

omfo

rt ra

ting

Occasion

Mean discomfort ratings over ten rating occasions

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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Seco

nds (

s)

Occasion, with training (occasion #1 to #4), baseline testing (occasion #5), experimental exposure #1 (occasion #6 to #9),

experimental exposure #2 (occasion #10 to #13), experimental exposure #3 (occasion #14 and 15), and post test (occasion #16).

K-D test mean times for 18 participants over 16 test occasions, i.e. including training

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140

ANAM

scor

e

Occasion

Mean of ANAM scores over all six ANAM occasions

Continous performance -Running memory

2-choice reaction

Logical relations

Pursuit tracking

Matching to sample

Mathematical processing

Manikin

Switching

SSM 2015:20

StrålsäkerhetsmyndighetenSwedish Radiation Safety Authority

SE-171 16 Stockholm Tel: +46 8 799 40 00 E-mail: [email protected] Solna strandväg 96 Fax: +46 8 799 40 10 Web: stralsakerhetsmyndigheten.se

2015:20 The Swedish Radiation Safety Authority has a comprehensive responsibility to ensure that society is safe from the effects of radiation. The Authority works to achieve radiation safety in a number of areas: nuclear power, medical care as well as commercial products and services. The Authority also works to achieve protection from natural radiation and to increase the level of radiation safety internationally.

The Swedish Radiation Safety Authority works proactively and preventively to protect people and the environment from the harmful effects of radiation, now and in the future. The Authority issues regulations and supervises compliance, while also supporting research, providing training and information, and issuing advice. Often, activities involving radiation require licences issued by the Authority. The Swedish Radiation Safety Authority maintains emergency preparedness around the clock with the aim of limiting the aftermath of radiation accidents and the unintentional spreading of radioactive substances. The Authority participates in international co-operation in order to promote radiation safety and fi nances projects aiming to raise the level of radiation safety in certain Eastern European countries.

The Authority reports to the Ministry of the Environment and has around 300 employees with competencies in the fi elds of engineering, natural and behavioural sciences, law, economics and communications. We have received quality, environmental and working environment certifi cation.

2015:20 the effects of mild, acute hypoxia on cognitive

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