2014 年 4 月 研究生读书报告
DESCRIPTION
2014 年 4 月 研究生读书报告. 王凯 硕 士研究生 临 床检验诊断学. Seminars In Cancer Biology. Cancer Discovery. A review of the current understanding and clinical utility of miRNAs in esophageal cancer - PowerPoint PPT PresentationTRANSCRIPT
2014年 4月研究生读书报告王凯硕士研究生临床检验诊断学
Seminars In Cancer Biology
A review of the current understanding and clinical utility of miRNAs in esophageal cancerComparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
Cancer Discovery
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
Four miRNAs (mi-R-25, -99a, -133a and -133b) showed good potential as diagnostic markers and interestingly five (mi-R-21, -27b, -126, - 143 and -145) appeared to be useful both as diagnostic and prognostic/predictive markers.
Summary of studies looking at miRNA expression in tumor tissues and non-tumor tissues
Summary of miRNAs identified to have a role in determining prognosis
Summary of key miRNAs identified as having a potential role in the diagnosis and/or prognosis of oesophageal cancer
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
11 EAC
23 fresh-frozen
primary tumors
NOTCH1 TP53 C:G>G:CA:T>C:G
Tumor Tissue EAC
12 ESCC
ESCC
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
Find out the drive gene
MicroRNAs matched with the drive gene
Quantitative detection of the expression of the gene and microRNA
Analyze the relationship between the expression of the gene and microRNAs
Experimental verification
• Sparkle of Inspiration
• Conclusion
• Genomic Analysis of Esophageal Cancer
• miRNAs In Esophageal Cancer
1 2
34
Thank You