Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada Universitas Airlangga untukdigunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. AriSutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

CORRELATION BETWEEN INSULIN RESISTANCE AND SMALLDENSE LDL INPATIENTS WITH T2DM (Cross sectional descriptive

Study In Surabaya)

Abstrak :

CORRELATION BETWEEN INSULIN RESISTANCE ANDSMALL DENSE LDL INPATIENTS WITH T2DM(Cross sectional descriptive Study In Surabaya)

Askandar Tjakroprawiro, Lea MS, Soebagijo Adi, Sri Murtiwi, Agung Pranoto,Hendromartono, Ari Sutjahjo, Sony WibisonoDiabetes and Nutrition Centre ‑ Department of Internal Medicine ‑ Dr, Soetomo HospitalAirlangga University School of Medicine, Surabaya

OBJECTIVE‑ LDL (low density lipoprotein) is the major carrier of cholesterol in human plasma, and assuch is intimately involved in the process atherosclerosis, All LDL is not created equal, There are differenttypes of LDL. Small dense LDL is more atherogenic or more toxic to the endothelium. It is more likely toenter the vessel wall, become oxidized and trigger atherosclerosis process. Causes of small dense LDL aremultiple. There is a genetic predisposition to have small dense LDL. An atherogenic lifestyle involvingminimal activity, Insulin resistance is the last major cause of small dense LDL, The aim of this study is todetermine correlation between small dense LDL and resistance insulin.RESEARCH DESIGN AND METHOD_ We conducted a cross sectional study in 50 type 2 DM patientsaged 21 ‑ 70 years. The type 2 DM was diagnosed according to PERKENI 2002 . Small dense LDLparticles are measured by ratio of LDL cholesterol with Apo B, if the ratio of LDL cholesterol with Apo Bis less than 1.2 revealed small dense LDL abnormality, Homeostasis model assessment of resistance insulin(HOMA‑R) was vsed to quantify of insulin resistance. HOMA R measurement is calculated by usingformula as follow Matheus (1985), Falutz (2002), Tjokroprawiro (2005). HOMA ‑ R abnormality is morethan 4.HOMA‑R = Fasting Insulin (_Ulml) x FPG (mmol/1) (N < 4)

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Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada Universitas Airlangga untukdigunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. AriSutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

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Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada Universitas Airlangga untukdigunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. AriSutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

22.5RESULTS‑ Data were analyzed for 50 subjects with type 2 DIVI with a mean age of 53,12 year, a meanBMI of 27.60 kg/m, a mean waist circumference for male of 96.07 m and for female of 113.7 cm, a meantriglycerida of 177.48 mg/dI, a mean LDL cholesterol of 126.62 mg/dI, a mean HDL cholesterol for male of45.22 and for female f 45.36 mg/dI, cholesterol total of 200.9 mg/dI, a mean HOMA R of 4.57, a mean maildense LDL of 1.134. A total of 34 patients (68%) have abnormality of small dense LDL. There wassignificant correlation between resistance insulin and small dense LDL r = 0.281, p = 0.04).CONCLUSION ‑ The resistance insulin was significantly correlated to the small dense LDL level inpatient with type 2 DM.

Keyword :

LDL ,T2DM

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