162

Acha SA, Ruesga M, Rodriguez C, Aguirregaviria J, Pancorbo M, Califano J,

Aguirre J. p53 mutation is rare in oral mucosa brushings from patients

previously treated for a head and neck squamous cell carcinoma. Oral

Oncology 45(8); 662; 2009.

Adhvaryu SG, Bhat RG, Daya PK, Trivedi AH, Dave BJ, Vyas RC, Jani KH.

SCE frequencies in lymphocytes of tobacco/betel nut chewers and patients

with oral submucous fibrosis. Br J Cancer 53; 141-143; 1986.

Adhvaryu SG, Dave BJ, Trivedi AH. An in vitro assessment of the genotoxic

potential of pan masalas. Indian J Med Res 90; 131-134; 1989.

Adhvaryu SG, Dave BJ, Trivedi AH. Cytogenetic surveillance of tobacco-

areca nut (mawa) chewers, including patients with oral cancers and

premalignant conditions. Mutat Res 261; 41-49; 1991.

Ahmed W, Qureshi H, Alam SE, Zuberi SJ. Association of upper

gastrointestinal lesions with addictions. J Pak Med Assoc 43; 176–177; 1993.

Albertini RJ. Biomarker responses in human populations: toward a worldwide

map. Mutat Res 428; 217-226; 1999.

Amarasena N, Ekanayaka AN, Herath L, Miyazaki H. Association between

smoking, betel chewing and gingival bleeding in rural Sri lanka. J Clin

Periodontol 30; 403–408; 2003.

Anuradha CD and Devi CSS. Studies on hematological profile and trace

elements in OSMF. J Clin Biochem Nutrition 19; 9-17; 1995.

ATSDR (1994). Agency for Toxic Substances and Disease Registry.

Toxicological profile for zinc. Atlanta, GA; U.S. Department of Health and

Human Services, Public Health Service.

Avon SL. Oral mucosal lesions associated with use of quid. J Can Dent Assoc

70(4); 244-248; 2004.

163

Awang MN. Estimation of arecoline contents in commercial areca (betel) nuts

and its relation to oral precancerous lesions. Singapore Med J 27 (4); 317-

320; 1986.

Babu KG. Oral cancer in India. Semi Oncol 28; 169-173; 2001.

Babu S, Bhat RV, Kumar PU, Sesikaran B, Rao KV, Aruna P, Reddy PR. A

comparative clinico-pathological study of oral submucous fibrosis in habitual

chewers of pan masala and betel quid. J Toxicol Clin Toxicol 34(3); 317-322;

1996.

Bagchi M, Balmoori J, Bagchi D, Ray SD, Kuszynski C, Stohs SJ. Smokeless

tobacco, oxidative stress, apoptosis and antioxidants in human oral

keratinocytes. Free Radic Biol Med 26; 992–1000; 1999.

Bagchi M, Balmoori J, Bagchi D, Stohs SJ, Chakrabarti J, Das DK. Role of

reactive oxygen species in the development of cytotoxicity with various forms

of chewing tobacco and pan masala. Toxicology 179; 247–255; 2002.

Bagchi M, Bagchi D, Stohs SJ. In vitro effects of a smokeless tobacco extract

on the production of reactive oxygen species by human oral epidermal cells

and rat hepatic mitochondria and microsomes, and peritoneal macrophages.

Arch Environ Contam Toxicol 30; 418–422; 1996.

Bagchi M, Kuszynski C, Patterson EB, Tang L, Bagchi D, Saani T, Stohs SJ.

In vitro free radical production in human oral keratinocytes induced by

smokeless tobacco extract. In vitro Toxicol 10; 263–274; 1997.

Bagwe AN and Bhisey RA. Occupational exposure to tobacco and resultant

genotoxicity in bidi industry workers. Mutat Res 299; 103–109; 1993.

Baker A, Gormally S, Saxena R, Baldwin D, Drumm B, Bonahm J, Portmann

B, Mowat AP. Copper associated liver disease in childhood. J Hepatol 23 (5);

538-43; 1995.

164

Balachandar V, Kumar BL, Suresh K, Sasikala K. Evaluation of chromosome

aberrations in subjects exposed to environmental tobacco smoke in

Tamilnadu, India. Bull Environ Contam Toxicol 81(3); 270-6; 2008.

Bates S and Vousden KH. p53 in signaling checkpoint arrest or apoptosis.

Curr Opin Genet Dev 6(1); 12-8; 1996.

Bauchinger M and Braselmann H. Use of the micronuclei in biological

dosimetry of absorbed radiation dose. In: Chromosomal Aberration, Basic and

Applied Aspects (Obe G, Natarajan AT, eds). Berlin:Springer-Verlag, 202–

211; 1990.

Beena PP, Trivedi PJ, Brahmbhatt MM, Shukla SN, Shah PM, Bakshi SR.

Micronuclei and Chromosomal aberrations in healthy tobacco chewers and

controls: A study from Gujarat, India. Arch Oncol 17(1-2); 7-10; 2009.

Belie¨n JA, Copper MP, Braakhuis BJ, Snow GB, Baak JP. Standardization of

counting micronuclei: definition of a protocol to measure genotoxic damage in

human exfoliated cells. Carcinogenesis 16; 2395–2400; 1995.

Benowitz NL. The use of biologic fluid samples in assessing smoke

consumption. In: Grabowski J, Bell CS, eds. Measurement in the analysis and

treatment of smoking behavior. NIDA research monograph no. 48.

Washington, DC: US GPO, 6-26; 1983.

Benowitz NL, Jacob P 3rd, Fong I, Gupta S. Nicotine metabolic profile in man;

comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp

Ther 268; 296-303; 1994.

Benowitz NL, Kuyt F, Jacob P, Jones RT, Osman AL Cotinine disposition and

effects. Clin Pharmacol Ther 34 (5); 604-11, 1983.

Benowitz NL and Sharp DS. Inverse relation between serum cotinine

concentration and blood pressure in cigarette smokers. Circulation 80; 1309-

12; 1989.

165

.

Bergstrom J. Cigarette smoking as a risk factor in chronic periodontal disease.

Comm Dent Oral Epidemiol 17; 245-247; 1989.

Bernard WS and Paul K. World Cancer Report World Health Organisation,

International Agency for Research on Cancer (IARC) pp. 11-21; 2003.

Betti C, Davini T, Giannessi L, Loprieno N, Barale R. Comparative studies by

comet test and SCE analysis in human lymphocytes from 200 healthy

subjects. Mutat Res 343; 201–207; 1995.

Bhatt AP and Dholakia HM. Mast cell density in oral submucous fibrosis. J

Ind Dent Assoc 48; 187-191; 1977.

Bhonsle RB, Murti PR, Daftary DK, Gupta PC, Mehta FS, Sinor PN, Irani RR,

Pindborg JJ. Regional variations in oral submucous fibrosis in India. Com

Dent Oral Epidemiol 15(4); 225-229; 1987.

Bhonsle RB, Murti PR, Gupta PC. Tobacco habits in India. In: Gupta PC,

Hamner JE, III. and Murti PR, eds, Control of Tobacco-related Cancers and

Other Diseases (Proceedings of an International Symposium January 15–19,

1990, TIFR, Bombay), Oxford, Oxford University Press, 25–46; 1992.

Blount PL, Galipeau PC, Sanchez CA, Neshat K, Levine DS, Yin J, Suzuki H,

Abraham JM, Meltzer SJ, Reid BJ. 17p allelic losses in diploid cells of patients

with Barrett's esophagus who develop aneuploidy. Cancer Res 54; 2292-329;

1994.

Bohrer PL, Filho MS, Paiva RL, da Silva IL, Rados PV. Assessment of

micronucleus frequency in normal oral mucosa of patients exposed to

carcinogens. Acta Cytol 49; 265-72; 2005.

Bolinder G, Alfredsson L, Englund A, de Faire U. Smokeless tobacco use and

increased cardiovascular mortality among Swedish construction workers. Am

J Public Health 84; 399–404; 1994.

166

Bonassi S, Neri M, Lando C, Ceppi M, Yi-ping Lin, Chang W, Holland N,

Micheline Kirsch-Volders, Zeiger E, Fenech M. The HUMN collaborative

group: Effect of smoking habit on the frequency of micronuclei in human

lymphocytes: results from the HUman MicroNucleus project. Mutat Res 543;

155-66; 2003.

Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, Micheline

Kirsch-Volders, Zeiger E, Ban S, Barale R, Maria Paola Bigatti, Bolognesi C,

Antonina Cebulska-Wasilewska, Fabianova E, Fucic A, Hagmar L, Joksic G,

Martelli A, Migliore L, Mirkova E, Maria Rosaria Scarfi, Zijno A, Norppa H,

Fenech M. An increased micronucleus frequency in peripheral blood

lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28(3);

625-31; 2007.

Boucher BJ and Mannan N. Metabolic effects of the consumption of Areca

catechu. Addict Biol 7; 103-10; 2002.

Boyle JO, Hakim J, Koch W, Vanderriet P, Hruban RH, Roa RA, Correo R,

Eby YJ, Ruppert JM, Sidransky D. The incidence of p53 mutations increases

with progression of head and neck cancer. Cancer Res 53; 4477–88; 1993.

Boyle P, Macfarlans GJ, Maisonneuve P, Zheng T, Scully C, Tedsceo B.

Epidemiology of mouth cancer in 1989; a review. J R Soc Med 83 (11); 724–

730; 1990.

Britto AP and Ravindran G. A review of cytogenetics and its automation. J

Med Sci 7; 1-18; 2007.

Brogger A, Hogstedt B, Knudsen l, Lambert B, Linnainmaak MG, Norsdenson

I, Reutewall C, Salonaa S, Skerfiving S, Sorsa M. An inter nordic prospective

study on cytogenetic end points and cancer risk. Cancer Genet Cytogenet 45;

85-92; 1990.

Brunnemann KD and Hoffmann D. Chemical composition of smokeless

tobacco products. In: Smokeless Tobacco or Health. An International

167

Perspective (Smoking and Tobacco Control Monograph No. 2; NIH Publ. No.

93-3461), Bethesda, MD, National Cancer Institute, 1992.

Brunnemann KD and Hoffmann D. Smoking and Tobacco Control

Monographs. National Cancer Institute; Chemical composition of smokeless

tobacco products; Vol. 2; 96–108; 1992.

Buckton KE, Hamilton GE, Paton L, Langland AO. Chromosome aberration in

irradiated ankylosing spondylitis patients. In: Evans HJ, Lloyd DC, editors.

Mutagen-induced chromosome damage in man. Edinburgh: Edinburgh Univ.

Press, 142– 50; 1978.

Buisson B and Bertrand D. Nicotine addiction: the possible role of functional

upregulation. Trends Pharmacol Sci 3; 130-6; 2002.

Burgaz S, Karahalil B, Canhi Z, Terzioglu F, Ancel G, Anzion RB, Bos RP,

Huttner E. Assessment of genotoxic damage in nurses occupationally

exposed to antineoplastics by the analysis of chromosomal aberrations. Hum

Exp Tox 21; 129-135; 2002.

Cairns J. Mutation selection and the natural history of cancer. Nature 255;

197–200; 1975.

Califano J, Van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S,

Corio R, Lee D, Greenberg B, Koch W, Sidransky D. Genetic progression

model for head and neck cancer; implications for field cancerization. Cancer

Res. 56; 2488-2492; 1996.

Canniff JP and Harvey W. Aetiology of oral submucous fibrosis: The

stimulation of collagen synthesis by extracts of arecanut. Int J Oral Surg

10(1); 163 -167; 1981.

Canniff JP, Batchelor JR, Dodi IA, Harvey W. HLA-typing in oral submucous

fibrosis. Tissue Antigens 26(2); 138-142; 1985.

168

Canniff JP, Harvey W, Harris M. Oral Submucous Fibrosis: Its pathogenesis

and management. Br Dent J 160; 429-434; 1986.

Carrano AV and Natarajan AT. Considerations for population monitoring using

cytogenetics techniques. ICPEMC publication 14. Mutat Res 204; 379– 406;

1988.

Casatelli G, Bonatti S, De Ferrari M, Scala M, Merue P, Margarino G,

Abbondandolo A. Micronucleus frequencies in exfoliated buccal cells in

normal mucosa, precancerous lesions and squamous cell carcinoma. Anat

Quant Cytol Histol 22(6); 486-92; 2000.

Ceylan E, Kocygit A, Gencer M, Aksoy N, Selek S. Increased DNA damage in

patients with chronic obstructive pulmonary disease who had once smoked or

been exposed to biomass. Respir Med 100; 1270–1276; 2006.

Chandra V and Ganguly M. Smoking among the elderly in rural Haryana:

(India): Lifeline: May 2002, 8:4. WHO SEARO, New Delhi, India.

Chang H, Qi C, Yi QL, Reece D, Stewart AK. p53 gene deletion detected by

fluorescence in situ hybridization is an adverse prognostic factor for patients

with multiple myeloma following autologous stem cell transplantation. Blood

105(1); 358-60; 2005.

Chang MC, Kuo MY, Hahn LJ, Hsieh CC, Lin SK, Jeng JH. Areca nut extract

inhibits the growth, attachment, and matrix protein synthesis of cultured

human gingival fibroblasts. J Periodontol 69; 1092-97; 1998.

Chang QZ, Tai HL, Chao QJ, Ba XW, Xiu L, Wei WL, Xiang QL, Yue HC.

Lymphocyte DNA damage in cigarette factory workers measured by the

Comet assay. Mutat Res 1; 444; 1999.

Charlotte J, Yuesheng J, Johan W, Jan Å, Michael D, Fredrik M. Karyotypic

heterogeneity and clonal evolution in squamous cell carcinomas of the head

and neck. Cancer Genetics and Cytogenetics 132(2); 85 – 96; 2002.

169

Chatterjee S, Dhar S, Sengupta B, Ghosh A, De M, Roy S, Raychowdhury R,

Chakrabarti S. Cytogenetic monitoring in human oral cancers and other oral

pathology: the micronucleus test in exfoliated buccal cells. Toxicol Mech

Methods 19(6-7); 427-33; 2009.

Chaturvedi H, Phukan R, Zoramtharga K, Hazarika N, Mahanta, J. Tobacco

use in Mizoram, India: sociodemographic differences in pattern. Southeast

Asian J Tropical Med Public Hlth 29; 66-70; 1998.

Chen CL, Chi CW, Chang KW, Liu TY. Safrole-like DNA adducts in oral tissue

from oral cancer patients with a betel quid chewing history. Carcinogenesis 20

(12); 2331–34; 1999.

Chen LC, Neubauer A, Kurisu W, Waldman FM, Ljung B-M, Goodson W,

Goldman ES, Moore D, Balazs M, Liu E, Mayall BH, Smith HS. Loss of

heterozygosity on the short arm of chromosome 17 is associated with high

proliferative capacity and DNA aneuploidy in primary human breast cancer.

Proc Natl Acad Sci USA 88; 3847-3851; 1991.

Chiba I, Muthumala M, Yamazaki Y, Uz Zaman A, Iizuka T, Amemiya A,

Shibata T, Kashiwazaki H, Sugiura C, Fukuda H. Characteristics of mutations

in the p53 gene of oral squamous-cell carcinomas associated with betel-quid

chewing in Sri Lanka. Int J Cancer 77; 839–42; 1998.

Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW,

DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and

cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97;

527–38; 1999.

Choucroun P, Gillet D, Dorange G, Sawicki B, Dewitte JD. Comet assay and

early apoptosis. Mutat Res 478 (1-2); 89-96; 2001.

Choudhury CR, Chowdhury A, Prasad RB, Shibahara T. Khaini chewing

damages chromosomes 2q, 3p and 21q; occurrence in a South Asian

population. Asian Pac J Cancer Prev 10(4); 715-6; 2009.

170

Chu NS. Sympathetic response to betel chewing. J Psychoact Drugs 27; 183–

186; 1995.

Chu NS. Effects of betel chewing on the central and autonomic nervous

systems. J Biomed Sci 8; 229–236; 2001.

Chu NS. Neurological aspects of areca and betel chewing. Addict Biol 7; 111–

114; 2002.

Cooper GM. Oncogenes. Jones and Bartlett, Inc., new York, 1990.

Danadevi K, Rozati R, Banu BS, Grover P. Genotoxic evaluation of welders

occupationally exposed to chromium and nickel using the Comet and

micronucleus assays. Mutagenesis 19(1); 35-41; 2004.

Das RK and Dash BC. Genotoxicity of ‘gudakhu’, a tobacco preparation. II. In

habitual users. Food Chem Toxicol 30; 1045–1049; 1992.

Dave BJ, Trivedi AH, Adhvaryu SG. Cytogenetic studies reveal increased

genomic damage among pan masala consumers. Mutagenesis 6; 159-163;

1991.

Dave BJ, Trivedi AH, Adhvaryu SG. Role of areca nut consumption in the

cause of oral cancers: A cytogenetic assessment. Cancer 70; 1017-23; 1992.

DeLeon J, Diza FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin

LP, Crooks PA. Total cotinine in plasma: a stable biomarker for exposure to

tobacco smoke. J Clin Psychopharmacol 22; 496–501; 2002.

DeM´eo M, Laget M, Castegnaro M, Dumenil G. Genotoxic activity of

potassium permanganate in acidic solutions. Mutat Res 260; 295–306; 1991.

Devendra HP and Jagdish VT. Clinico-pathological correlation of micronuclei

in oral squamous cell carcinoma by exfoliative cytology. J Oral Maxillo Facial

Pathol 12; 2-7; 2008.

171

Dockrat I and Shear M. Oral submucous fibrosis in Natal. Proceedings of the

International Academy of Oral Pathology. New York, Gorden and Breash.

1970.

Domino EF. Nontobacco sources of cotinine in the urine of non-smokers. Clin

Pharmacol Ther 57; 479; 1995.

Dönbak L, Celik M, Demirhan I, Nagas S. Genotoxic damage in Maras

powder consumers from Kahramanmaras province of Turkey. Russian J

Genet 43 (5); 513-517; 2007

Dunn BP and Stich HF. 32P-Postlabelling analysis of aromatic DNA adducts in

human oral mucosal cells. Carcinogenesis 7; 1115–1120; 1986.

Eipe N. The chewing of betel quid and oral submucous fibrosis and

anesthesia. Anesth Analg 100 (4); 1210-3; 2005.

Etzel RA. A review of the use of saliva cotinine as a marker of tobacco smoke

exposure. Prev Med 19;190-7; 1990.

Fadl-Elmula I. Chromosomal changes in uroepithelial carcinomas. Cell

Chromosome 10; 41; 2005.

Fant RV, Henningfield JE, Nelson RA, Pickworth WB. Pharmacokinetics and

pharmacodynamics of moist snuff in humans. Tob Control 8; 387-92; 1999.

Faust F, Kassie F, Knasmuller S, Boedecker RH, Mann M, Mersch

Sundermann V. The use of the alkaline comet assay with lymphocytes in

human biomonitoring studies. Mutat Res 566; 209–29; 2004.

Fenech M. Cytokinesis-block micronucleus techniques: a detailed description

of the method and its application to genotoxicity studies in human populations.

Mutat Res 161; 193–198; 1993.

Fenech M. The in vitro micronucleus technique. Mutat Res 455; 81-95; 2000.

172

Fenech M. Biomarkers of genetic damage for cancer epidemiology.

Toxicology 181; 411-416; 2002.

Fenech M. Nutritional treatment of genome instability: a paradigm shift in

disease prevention and in the setting of recommended dietary allowances.

Nutrition Res Rev 16; 109–22; 2003.

Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc 2; 104–

1084; 2007.

Fenech M and Morley AA. Measurement of micronuclei in lymphocytes. Mutat

Res 147; 29–36; 1985.

Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E.

HUMN project: detailed description of the scoring criteria for the cytokinesis-

block micronucleus assay using isolated lymphocyte cultures. Mutat Res 534;

65-75; 2003.

Fenech M, Holland N, Chang WP, Zeiger E, Bonassi S. The HUman

MicroNucleus Project - An international collaborative study on the use of the

micronucleus technique for measuring DNA damage in humans. Mutat Res

428; 271-283; 1999.

Fenech M, Perepetskaya G, Mikhalevic L. A more comprehensive application

of the micronucleus techni que for biomonitoring of genetic damage rates in

human populations. Experiences from the Chernobyl catastrophe. Environ

Mol Mutagen 30; 112–118; 1997.

Feyerabend C, Ings RM, Russell MAH. Nicotine pharmacokinetics and its

application to intake from smoking. Br J Clin Pharmacol 19; 239–247; 1985.

Florent M, Godard T, Ballet JJ, Gauduchon P, Sola B. Detection by the comet

assay of apoptosis induced in lymphoid cell lines after growth factor

deprivation. Cell Biol Toxicol 15(3); 185-92; 1999.

173

Fox JW, Gyorfi T, Dragulev B. Effects of smokeless tobacco extract on HT

1080 cell adhesion, pp125FAK phosphorylation and apoptosis. In vitro Toxicol

8; 339–47; 1995.

Fucic A, Markucic D, Mijic A, Jazbec AM. Estimation of genome damage after

exposure to ionising radiation and ultrasound used in industry. Environ Mol

Mutagen 36; 47–51; 2000.

Galloway SM. Cytotoxicity and chromosome aberrations in vitro: experience in

industry and the case for an upper limit on toxicity in the aberration assay.

Environ Molec Mutagen 35; 191–201; 2000.

Gandhi G, and Kaur R. Cytogenetic studies in exfoliated cells of high cancer

risk groups, Pan M asala Chewers. Human Ecol 9; 221-28; 2000.

Gao S, Eiberg H, Krogdahl A, Liu CJ, Sørensen JA. Cytoplasmic expression

of E-cadherin and β-catenin correlated with LOH and hypermethylation of the

APC gene in oral squamous cell carcinoma. J Oral Pathol Medi 34; 116–119;

2005.

Gao YJ, Yin XM, Wu HJ. Relationship between vertical root fracture and the

habits of chewing betel nut. Hunan Yi Ke Da Xue Xue Bao 26; 161–162;

2001.

GCRI: The Gujarat Cancer & Research Institute, Hospital based Cancer

Registry, 2001.

Ghose UR and Parida BB. Cytological study of exfoliated buccal mucosa cells

of the tribes in Orissa State (India) with high risk of oral cancer. Ind J Cancer

32; 95–99; 1995.

Gilman SL and Xun Zhou., "Introduction" in Smoke; p. 26; 2004

Gisselsson D, Jonson T, Petersén Å, Strömbeck B, Dal Cin P, Höglund M,

Mitelman F, Mertens F, Mandahl M. Telomere dysfunction triggers extensive

174

DNA fragmentation and evolution of complex chromosome abnormalities in

human malignant tumours. Proc Natl Acad Sci USA 98; 12683-88; 2001.

Gonzalez YM, Nardin N D, Grossi SG, Machtei EE, Genco RJ, Nardin ED.

Serum cotinine levels, smoking and periodontal attachment loss. J Dent Res

75; 796-802; 1996.

Gopalan C, Rama Sastri BV, Balasubramanian SC. Nutritive value of Indian

food. Third Edition, revised and updated by Narasinga Rao BS., Deosthale

YG, Pant KC, National Institute of Nutrition, Indian Council of Medical

Research, Hyderabad, India: 1991.

Gregory H, Jianhua ZG, Marta V, Michael N, Alice C, Savita PC, Shi-Qi Wu.

Fluorescent In Situ Hybridization Evaluation of p53 Gene Deletions at a

Tumor Interface of Lingual Carcinoma. The Laryngoscope 110(9); 1474–

1478; 2000.

Guitiérrez S, Carbonell E, Galofré P, Creus A, Marcos R. Cytogenetic damage

after 131-iodine treatment for hyperthyroidism and thyroid cancer. Eur J Nucl

Medi 26(12); 1589-96; 1999.

Gupta OP. An epidemiological study of periodontal disease in Trivandrum,

India. J Dent Res 43; 876; 1964.

Gupta PC. A study of dose response relationship between tobacco habits and

oral leukoplakia. Br J Cancer 50; 527-531; 1984.

Gupta PC. Gutka; a major new tobacco hazard in India. Tob Control 8; 132

1999.

Gupta PC. Mouth cancer in India: a new epidemic? J Indian Med Assoc 97;

370-373; 1999.

Gupta PC and Ball K. India: Tobacco Tragedy. Lancet 335-595; 1990.

Gupta PC and Nandakumar A. Oral cancer scene in India. Oral Diseases 5; 1-

2; 1999.

175

Gupta PC and Ray CS. Smokeless tobacco and health in India and South

Asia. Respirology 8(4); 419-431; 2003.

Gupta PC and Ray CS. Tobacco and youth in the South East Asian region.

Indian J Cancer 39; 5–33; 2002.

Gupta PC and Warnakulasuriya S. Global epidemiology of areca nut usage.

Addiction Biol 7; 77-83; 2002.

Gupta PC, Bhonsle RB, Murti PR. Oral mucosal lesions related to betel quid

chewing-an epidemiological assessment from a 10-year follow-up study of

12,212 individuals in Ernakulam district, Kerala, India. Dent J Malayasia 18;

38-42; 1997.

Gupta PC, Bhonsle RB, Murti PR, Daftary DK, Mehta FS, Pindborg JJ. An

epidemiologic assessment of cancer risk in oral precancerous lesions in India

with special reference to nodular leukoplakia. Cancer 63; 2247-2252; 1989.

Gupta PC, Hebert JR, Bhonsle RB, Sinor PR, Mehta H, Mehta FS. Dietary

factors in oral leukoplakia and submucous fibrosis in a population based case

control study in Gujarat, India. Oral Diseases 4 (6); 200-206; 1998.

Gupta PC, Mehta FS, Daftary DK, Pindborg JJ, Bhonsle RB, Jalnawalla PN,

Sinor PN, Pitkar VK, Murti PR, Irani RR, Shah HT, Kadam PM, Iyer KSS, Iyer

HM, Hegde AK, Chandrashekar GK, Shroff BC, Sahiar BE, Mehta MN.

Incidence rates of oral cancer and natural history of oral precancerous lesions

in a 10-year follow-up study of Indian villagers. Community Dent Oral

Epidemiol 8; 283–333; 1980.

Gupta PC, Pindborg JJ, Bhonsle RB, Murti PR, Mehta FS, Aghi MB, Daftary

DK, Shah HT. Intervention study for primary prevention or oral cancer among

36,000 Indian tobacco users. Lancet 1 (8492); 1235-1239; 1986.

Gupta PC, Sinor PN, Bhonsle RB, Pawar VS, Mehta HC. Oral submucous

fibrosis in India; A new epidemic? Natl med J India 11; 113–116; 1998.

176

Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen L, Norppa H,

Reuterwall C. The European Study Group on Cytogenetic Biomarkers and

Health, Chromosomal aberrations in lymphocytes predict human cancer. A

report from the European Study Group on Cytogenetic Biomarkers and Health

(ESCH), Cancer Res 58; 4117–4121; 1998.

Hagmar L, Brogger A, Hansteen IL, Heim S, Hogstedt B, Knudsen L, Lambert

B, Linnainmaa K, Mitelman F, Nordenson I, Reuterwall C, Salomaa SI,

Skerfving S, Sorsa M, Cancer risk in human predicted by increased levels of

chromosomal aberrations in lymphocytes; Nordic Study Group on the Health

Risk of Chromosome Damage. Cancer Res 54; 2919–2922; 1994.

Hall PA, Mckee PH, Menage HP, Dover R, Lane DP. High levels of p53

protein in UV-irradiated normal human skin. Oncogene 8; 203-207; 1993.

Hande AH and Chaudhary MS. Cytomorphometric analysis of buccal mucosa

of tobacco chewers. Rom J Morphol Embryol 51(3); 527-32; 2010.

Harris CC. p53 Tumor Suppressor Gene: At the Crossroads of Molecular

Carcinogenesis, Molecular Epidemiology and Cancer Risk Assessment.

Environ Health Perspec 3; 104; 435-9;1996.

Harris CC. p53: at the crossroads of molecular carcinogenesis and risk

assessment. Science 262; 1980–81; 1993.

Harris ED, Blount JE, Leach RM. Localization of lysyl oxidase in hen oviduct;

implications in egg shell membrane formation and composition. Science 208;

55–6; 1980.

Harvey W, Scutt A, Meghji S, Caniff JP. Stimulation of human buccal mucosa

fibroblast in vitro by betel nut alkaloids. Arch Oral Biol 3(1); 45-49; 1986.

Hassan GM. Effects of some synthetic coloring additives on DNA damage and

chromosomal aberrations of rat. Arab J Biotech 13(1); 13-24; 2010.

177

Hatsukami DK and Severson HH. Oral spit tobacco; Addiction, prevention and

treatment. Nicotine Tob Res 1; 21–44; 1999.

Haufroid V and Lison D. Urinary cotinine as a tobacco-smoke exposure index:

a minireview. Int Arch Occup Environ Hlth 71; 162–168; 1998.

Haveric A, Haveric S, Ibrulj S. Micronuclei frequencies in peripheral blood and

buccal exfoliated cells of young smokers and non-smokers. Toxicol Mech

Methods 20(5); 260-6; 2010.

Hecht SS and Hoffman D. Tobacco specific nitrosamines, an important group

of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9; 875-884;

1988.

Hecht SS, Chen CB, Hirota N, Ornaf RM, Tso TC, Hoffmann D. Tobacco-

specific nitrosamines: formation from nicotine in vitro and during tobacco

curing and carcinogenicity in strain A mice. J Natl Cancer Inst 60; 819–824;

1978.

Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced

cancer. Nature Rev Cancer 3; 733-744; 2003.

Heddle J. A rapid in vivo test for chromosome damage. Mutat Res 18; 187–

190; 1973.

Heinzel PA, Balaram P, Bernard HU. Mutations and polymorphisms in the

p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers. Int J

Cancer 68; 420–23; 1996.

Henningfield JE, Fant RV, Tomar SL. Smokeless tobacco; An addicting drug.

Adv Dent Res 11; 330–335; 1997.

Hirayama T. An epidemiological study of oral and pharyngeal cancer in

Central and South-East Asia. Bull WHO 34; 41-69; 1966.

178

Hoffmann D, Djordjevic MV, Fan J, Zang E, Glynn T, Connolly GN. Five

leading U.S. commercial brands of moist snuff in 1994; Assessment of

carcinogenic N-nitrosamines. J Natl Cancer Inst 87; 1862–69; 1995.

Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, Knasmueller

S, Fenech M. The micronucleus assay in human buccal cells as a tool for

biomonitoring DNA damage; the HUMN project perspective on current status

and knowledge gaps. Mutat Res 659; 93–108; 2008.

Hopman AH, Voorter CE, Ramaekers FC. Detection of genomic changes in

cancer by in situ hybridization. Mole Biol Reports Journal 19; 31-44; 1994.

Hsieh LL, Wang PF, Chen IH, Liao CT, Wang HM, Chen MC, Chang JTC,

Cheng AJ. Characteristics of mutations in the p53 gene in oral squamous cell

carcinoma associated with betel quid chewing and cigarette smoking in

Taiwanese. Carcinogenesis 22; 1497–1503; 2001.

Hukkanen J, Jacob P, Benowitz NL. Metabolism and disposition kinetics of

nicotine. Pharmacol Rev 57; 79-115; 2005.

Hungerford DA. Leucocytes cultured from small inocula of whole blood and

the preparation of metaphase chromosomes by treatment with hypotonic KCl

stain. Technol 40; 333; 1965.

IARC (1985). Betel-quid and areca-nut chewing. Monographs on the

evaluation of the carcinogenic risk of chemicals to humans. Vol. 37. Lyon,

France: International Agency for Research on Cancer, pp. 141-202.

IARC (2002). Monographs on the evaluation of carcinogenic risks to humans.

Tobacco smoke and involuntary smoking. Vol. 83. Lyon (France); WHO; p.

1452.

IARC (2004). Monographs on the Evaluation of Carcinogenic Risks to

Humans, Vol. 85, Betel-quid and Areca nut Chewing and Some Areca nut

Related Nitrosamines, Lyon.

179

IARC (2007). Monographs on the evaluation of carcinogenic risks to humans.

Vol. 89, Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines.

IARC, Lyon.

Ibrahim SO, Vasstrand EN, Johannessen AC, Idris AM, Magnusson B, Nilsen

R, Lillehaug JR. Mutations of the p53 gene in oral squamous-cell carcinomas

from Sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers

from the Sudan and Scandinavia. Int J Cancer 81; 527–534; 1999.

Idle JR. Titrating exposure to tobacco smoke using cotinine - a minefield of

misunderstandings. Clin Epidemiol 43; 313–317; 1990.

Ishida K, Ito S, Wada N, Deguchi H, Hata T, Hosoda M, Nohno T. Nuclear

localization of beta-catenin involved in precancerous change in oral

leukoplakia. Mol Cancer 6; 62; 2007.

Jacob BJ, Straif K, Thomas G, Ramadas K, Mathew B, Zhang

ZF, Sankaranarayanan R, Hashibe M. Betel quid without tobacco as a risk

factor for oral precancers. Oral Oncology 40(7); 697–704; 2004.

Jaju RJ, Patel RK, Bakshi SR, Trivedi AH, Dave BJ, Adhvaryu SG.

Chromosome damaging effects of pan masala. Cancer Lett 65; 221–226;

1992.

Jarvis MJ, Goddard E, Higgins V, Feyerabend C, Bryant A, Cook DG.

Children’s exposure to passive smoking in England since the 1980s: cotinine

evidence from population surveys. BMJ 321; 343–345; 2000.

Jarvis MJ, Tunstall-Pedoe H, Feyerabend C, Vesey C, Saloojee Y.

Comparison of tests used to distinguish smokers from nonsmokers. Am J

Public Health 77; 1435–8; 1987.

Jayadeep A, Raveendran Pillai K, Kannan S, Nalinakumari KR, Mathew B,

Krishnan Nair M, Menon VP. Serum levels of copper, zinc, iron and

ceruplasmin in oral leukoplakia and squamous cell carcinoma. J Exp Clin

Cancer Res 16(3); 295-300; 1997.

180

Jayakumar R and Sasikala K. Evaluation of DNA damage in jewellery

workers occupationally exposed to nitric oxide. Environ Toxi Pharmacol 26(2);

259-261; 2008.

Jean LL and Pierre F. 17p Deletion in Acute Myeloid Leukemia and

Myelodysplastic Syndrome Analysis of Breakpoints and Deleted Segments by

Fluorescence In Situ. Blood 91(3);1008-1015; 1998.

Jeffrey M Levsky and Robert H Singer. Fluorescence in situ hybridization:

past, present and Future. J Cell Science 116; 2833-2838; 2003.

Jeng JH, Chang MC, Hahn LJ. Role of areca nut in betel quid-associated

chemical carcinogenesis; current awareness and future perspectives. Oral

Oncol 37(6); 477–492; 2001.

Jeng JH, Hahn LJ, Lin BR, Hsieh CC, Chan CP, Chang MC. Effects of areca

nut, inflorescence piper betel extracts and arecoline on cytotoxicity, total and

unscheduled DNA synthesis in cultured gingival keratinocytes. J Oral Path

Med 28; 64-71; 1999.

Jensen RA and Page DL. p53: the promising story continues to unfold. Hum

Pathol 24; 455–56; 1993.

Jin Y, Mertens F, Jin C, Akervall J, Wennerberg J, Gorunova L, Mandahl N,

Heim S, Mitelman F. Non-random chromosome abnormalities in shortterm

cultured primary squamous cell carcinomas of the head and neck. Cancer

Res 55; 3204-3210; 1995.

John SWM, Weitzner G, Rozen R, Scriver CR. A rapid procedure for

extracting genomic DNA from leukocytes. Nucleic Acids Res 19(2); 408; 1991.

Jones NJ, Kadhim MA, Hoskins PL, Parry JM, Waters R. 32P-postlabelling

analysis and micronuclei induction in primary Chinese hamster lung cells

exposed to tobacco particulate matter. Carcinogenesis 12; 1507–1514; 1991.

181

Joshi M, Verma Y, Gautam K, Parmar G, Kumar S. Evaluation of cytogenetic

damage among areca nut and tobacco chewers. Arch Oral Biol 59(1); 64-68;

2011.

Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW.

Participation of p53 protein in the cellular response to DNA damage. Cancer

Res 51; 6304–6311; 1991.

Kastan MB, Zhan Q, El Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS,

Vogelstein B, Fornance AJ. A mammalian cell cycle checkpoint pathway

utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71; 587-

597; 1992.

Kausar A, Giri S, Mazumdar M, Giri A, Roy P, Dhar P. Micronucleus and other

nuclear abnormalities among betel quid chewers with or without sadagura, a

unique smokeless tobacco preparation, in a population from North-East India.

Mutat Res 677(1-2); 72-5; 2009.

Kayal JJ, Trivedi AH, Dave BJ, Nair J, Nair VJ, Bhide SV, Goswami VC,

Adhvaryu SG. Incidence of micronuclei in oral mucosa of users of tobacco

products singly or in various combinations. Mutagenesis 8; 31-35; 1993.

Kirsch-Volders M, Sofuni T, Aardema M, Albertini S, Eastmond D, Fenech M,

Ishidate M Jr, Kirchner S, Lorge E, Morita T, Norppa H, Surrallés J,

Vanhauwaert A, Wakata A. Report from the in vitro micronucleus assay

working group. Mutat Res 540; 153-163; 2003.

Kitagawa K, Kunugita N, Katoh T, Yang M, Kawamoto T. The significance of

the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping

method of CYP2A6 using a single PCR-RFLP. Biochem Biophys Res

Commun 262; 146–151; 1999.

Kleier C, Werkmeister R, Joos U. Zinc and vitamin A deficiency in diseases of

the mouth mucosa. Mund Kiefer Gesichtschir 2(6); 320-5;1998.

182

Klesges RC, Debon M, Ray JW. Are selfreports of smoking rate biased?

Evidence from the Second National Health and Nutrition Examination Survey.

J Clin Epidemiol 48; 1225-1233; 1995.

Ko YC, Chiang TA, Chang SJ, Hsieh SF. Prevalence of betel quid chewing

habit in Taiwan and related sociodemographic factors. J Oral Pathol Med 21;

261-264; 1992.

Kresty LA, Carmella SG, Borukhova A, Akerkar SA, Gopalkrishnan R, Harris

RE, Stoner GD, Hecht SS. Metabolites of a tobacco specific nitrosamine, 4-

(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in urine of smokeless

tobacco users. Relationship between urinary biomarkers and oral leukoplakia.

Cancer Epidemiol. Biomarkers Prev 5(7); 521-525; 1996.

Krishnadath KK, Tilanus HW, van Blankenstein M, Hop WC, Teijgeman

R, Mulder AH, Bosman FT, van Dekken H. Accumulation of genetic

abnormalities during neoplastic progression in Barrett’s esophagus. Cancer

Res 55; 1971–1976; 1995.

Krishnamurthi S and Shantha V. An overview of oral cancer control in south

India, in Varma AK (ed): Oral Oncology. Proceeding of the Third International

Congress on oral cancer, Vol IIIA. Madras, India, MacMillan, 1-6; 1994.

Kuerbitz S, Plunkett BS, Walsh WV, Kastan M. Wild-type p53 is a cell cycle

checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89;

7491-7495; 1992.

Kumar A, Sharma SC, Sharma P, Om Chandra, Singhal KC, Amit Nagar.

Beneficial effect of oral zinc in the treatment of oral submucous fibrosis. Ind J

Pharmacol 23; 236-241; 1991.

Kumar S. Pan masala chewing induces deterioration in oral health and its

implications in carcinogenesis. Toxicol Mech Methods 18; 665-677; 2008.

Kumar S, Parmar G, Saiyed HN. Nut and tobacco chewing. Br Dent J 197;

292; 2004.

183

Kwan HW. A statistical study on oral carcinomas in Taiwan with emphasis on

the relationship with betel nut chewing; A preliminary report. J Formosa med

Assoc 75; 497–505; 1976.

Lafi A and Parry JM. Cytogenetic activities of tobacco particulate matter

(TPM) derived from a low to middle tar British cigarette. Mutat Res 201; 365–

374; 1988.

Larsson A, Axéll T, Andersson G. Reversibility of snuff dippers’ lesion in

Swedish moist snuff users; A clinical and histologic follow-up study. J oral

Pathol Med 20; 258–264; 1991.

Lazarus P, Idris AM, Kim J, Calcagnotto A, Hoffmann D. p53 Mutations in

head and neck squamous cell carcinomas from Sudanese snuff (toombak)

users. Cancer Detect Prev 20; 270–78; 1996 (a).

Lazarus P, Stern J, Zwiebel N, Fair A, Richie JP, Schantz, S. Relationship

between p53 mutation incidence in oral cavity squamous cell carcinomas and

patient tobacco use. Carcinogenesis 17; 733–739; 1996 (b).

Lee HC, Yin PH, Yu TN, Chang YD, Hsu WC, Kao SY, Chi CW, Liu TY, Wei

YH. Accumulation of mitochondrial DNA deletions in human oral tissues—

Effects of betel quid chewing and oral cancer. Mutat Res 493; 67–74; 2001.

Lee JJ, Hong WK, Hittelman WN, Mao L, Lotan R, Shin DM, Benner SE, Xu

XC, Jin S. Lee, Vali M. Papadimitrakopoulou, Clarissa Geyer, Cherie

Perez, Jack W Martin, Adel K El-Naggar and Scott M. Lippman. Predicting

cancer development in oral leukoplakia: ten years of translational research.

Clin Cancer Res 6; 1702–1710; 2000.

Lee JM, Abramson JL, Kandel R, Donehower LA, Bernstein A. Susceptibility

to radiation-carcinogenesis and accumulation of chromosomal breakage in

p53 deficient mice. Oncogene 9; 3731–3736; 1994.

184

Lee KW and Chin CT. The effects of betel nut chewing on buccal mucosa of

296 Indians and Malays in West Malaysia. A clinical study. Br J Cancer 24;

433-441; 1970.

Lewińska D, Palus J, Stepnik M, Dziubałtowska E, Beck J, Rydzyński K, Natarajan

AT, Nilsson R. Micronucleus frequency in peripheral blood lymphocytes and

buccal mucosa cells of copper smelter workers, with special regard to arsenic

exposure. Int Arch Occup Environ Hlth 80(5); 371-80; 2007.

Lin CC, Chang MC, Chang HH, Wang TM, Tseng WY, Tai TF, Yeh HW, Yang

TT, Hahn LJ, Jeng JH. Areca nut-induced micronuclei and cytokinesis failure

in Chinese hamster ovary cells is related to reactive oxygen species

production and actin filament deregulation. Environ Mol Mutagen 50; 367-374;

2009.

Lin SC, Chen YJ, Kao SY, Hsu MT, Lin CH, Yang SC, Liu TY, Chang KW.

Chromosomal changes in betel-associated oral squamous cell carcinomas

and their relationship to clinical parameters. Oral Oncol 38; 266–273; 2002.

Lin MH, Liu SY, Liu YC. Autophagy induction by a natural ingredient of areca

nut. Autophagy 4; 967-968; 2008.

Lin SK, Chang YJ, Ryu SJ, Chu NS. Cerebral hemodynamic responses to

betel chewing; A Doppler study. Clin Neuropharmacol 25; 244–250; 2002.

Linder MC and Hazegh-Azam M. Copper biochemistry and molecular biology.

Am J Clin Nutr 63(5); 797-811; 1996.

Ling LJ, Hung SL, Tseng SC, Chen YT, Chi LY, Wu KM, Lai YL. Association

between betel quid chewing, periodontal status and periodontal pathogens.

Oral Microbiol Immunol 16; 364–36; 2001.

Livingston GK, Reed RN, Olson BI, Lockey JE. Induction of nuclear

aberrations by smokeless tobacco in epithelial cells of human oral mucosa.

Environ Mol Mutagenesis 15; 136-144; 1990.

185

Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell

cycle arrest and gene amplification potential accompany loss of wild-type p53.

Cell 70(6); 923-35; 1992.

Loechler EC, Green CL, Essigmann JM. In vivo mutagenesis by O6-

methylguanine built into a unique site in a viral genome. Proc Natl Acad Sci

USA 81; 6271-6275; 1984.

Lou J, Zhou G, Chu G, Jiang J, Huang F, Zheng S, Lu Y, Li X, He J. Studying

the cyto-genotoxic effects of 12 cigarette smoke condensates on human

lymphoblastoid cell line in vitro. Mutat Res 696(1); 48-54; 2010.

Lu CT, Lan SJ, Hsieh CC, Yang MJ, Ko YC, Tsai CC, Yen YY. Prevalence

and characteristics of areca nut chewers among junior high school students in

Changhua county, Taiwan. Com Dent Oral Epidemiol 21(6); 370-373; 1993.

Lucero L, Pastor S, Suarez S, Durban R, Gomez C, Parron T, Creus A,

Marcos R. Cytogenetic biomonitoring of Spanish greenhouse workers

exposed to pesticides: micronuclei analysis in periopheral blood lymphocytes

and buccal epithelial cells. Mutat Res 464; 255-62; 2000.

Ma RH, Tsai CC, Sheih TY. Increased lysyl oxidase activity in fibroblasts

cultured from Oral Submucous Fibrosis associated with betel nut chewing in

Taiwan. J Oral Pathol Med 24(9); 407-13; 1995.

Mabrouk I, Baccouche S, El-Abed R, Mokdad-Gargouri R, Mosbah A, Said S,

Daoud J, Frikha M, Jlidi R, Gargouri A. No evidence of correlation between

p53 codon 72 polymorphism and risk of bladder or breast carcinoma in

Tunisian patients. Ann NY Acad Sci 1010; 764–770; 2003.

Mackay J, Steel CM, Elder PA, FoiTest APM, Evans HJ. Allele loss on short

arm of chromosome 17 in breast cancer. Lancet 47(2);1384-1385; 1988.

Mahale A and Saranath D. Microsatellite alterations on chromosome 9 in

chewing tobacco-induced oral squamous cell carcinomas from India. Oral

Oncol 36; 199-206; 2000.

186

Maher R, Lee AJ, Warnakulasuriya KAAS, Lewis JA, Johnson NW. Role of

areca nut in the causation of oral submucous fibrosis; a casecontrol study in

Pakistan. J Oral Pathol Med 23; 65–69; 1994.

Mancini G, Carbonara AG, Heremans JF. Quantification of antigens by single

radial immunodiffusion. Int J Immunology 2; 235-254; 1965.

Mangipudy RS and Vishwanatha JK. Role of nitric oxide in the induction of

apoptosis by smokeless tobacco extract. Mol cell Biochem 200; 51–57; 1999.

Manikantan P, Balachandar V, Sasikala K, Mohanadevi S. Lymphocyte DNA

Damage in Chewing Tobacco Users of Coimbatore, Tamilnadu, by using

Comet Assay. J Hum Ecol 31(1); 53-58; 2010.

Manoj BM and Rajani AB. Occupational exposure to bidi tobacco increases

chromosomal aberrations in tobacco processors. Mutat Res 334(2); 139-144;

1995.

Martin GC, Brown JP, Eifler CW, Houston GD. Oral leukoplakia status 6

weeks after cessation of smokeless tobacco use. J Am Dent Assoc 130; 945-

954; 1999.

Matakidou A, Eisen T, Houlston RS. TP53 polymorphisms and lung cancer

risk: a systematic review and meta-analysis. Mutagenesis 18; 377–85; 2003.

Mathers CD and Loncar D. Projections of global mortality and burden of

disease from 2002 to 2030. Public Library of Science Medicine 3(11); 442;

2006.

McGurk M and Craig GT. Oral submucous fibrosis: Two cases of malignant

transformation in Asian immigrants. Br Surg 22; 56-64; 1984.

Meghji S, Caniff JP, Harvey W, Scott A, Phillipson D. Inhibition of collagenase

activity by areca nut tannins: A mechanism of collagen accumulation in oral

submucous fibrosis. J Dent Res 61; 545; 1982.

187

Mehta FS and Hamner JE III. Tobacco-Related Oral Mucosal Lesions and

Conditions in India. Jaypee Brothers Medical Publishers, New Delhi, 1993.

Mehta FS, Gupta MB, Pindborg JJ, Bhonsle RB, Jalnawalla PN, Sinor PN; An

Intervention study of oral cancer and pre cancer in rural Indian populations; A

preliminary report. Bull World Hlth Org 60; 441-46; 1982.

Mehta FS, Gupta PC, Daftary DK, Pindborg JJ and Choksi SK. An

epidemiological study of oral cancer and precancerous conditions among

101,761 villagers in Maharashtra, India. Int J Cancer 10; 134-141; 1972.

Mehta FS, Pindborg JJ, Gupta PC, Daftary DK. Epidemiologic and histological

study of oral cancer and leukoplakia among 50,915 villagers in India. Cancer

24; 832-49; 1969.

Mehta FS, Pindborg JJ, Hamner JE, Gupta PC, Daftary DK, Sahiar BE, Shroff

BC, Sanghvi LD, Bhonsle RB, Choksi SK, Dandekar VV, Mehta YN, Pitkar

VK, Sinor PN, Shah NC, Turner PS, Upadhyay SA. A report on investigations

of oral cancer and precancerous conditions in Indian rural population. 1966-

1969, Copenhagen, Munksgaard, pp 48, 68, 89,107,120; 1971.

Mehta FS, Sanjana MK, Barretto MA, Doctor R. A relation of betel leaf

chewing to periodontal disease. J Am Dent Assoc 50; 531-36; 1955.

Merchant A, Husain SS, Hosain M, Fikree FF, Pitiphat W, Siddiqui AR,

Hayder SJ, Haider SM, Ikram M, Chuang SK, Saeed SA. Paan without

tobacco; an independent risk factor for oral cancer. Int J Cancer 86; 128-31;

2000.

MFMER; 1998-2010 Mayo Foundation for Medical Education and Research.

Milic M, Kasuba V, Orescanin V, Zeljezic D, Kopjar N, Rozgaj R.

Chromosome damage in workers in cigarette manufacturing industry. J Appl

Toxicol 28(3); 399-404; 2008.

188

Mojidra B, Archana K, Gautam A, Verma Y, Lakkad BC, Kumar S. Evaluation

of genotoxicity of panmasala employing chromosomal aberration and

micronucleus assay in bone marrow cells of the mice. Toxicol Ind Health 25;

467-71; 2009.

Moller IJ, Pindborg JJ, Effendi I. The relation between betel chewing and

dental caries. Scand J Dent Res 85(1); 64-70; 1977.

Moller P, Knudsen LE, Loft S, Wallin H. The comet assay as a rapid test in

biomonitoring occupational exposure to DNA-damaging agents and effect of

confounding factors. Cancer Epidemiol Biomarkers Prev 9; 1005–1015; 2000.

Moore LE, Warner LM, Smith AH, Kalman D, Smith MT. Use of the

fluorescent micronucleus assay to detect the genotoxic effects of radiation

and arsenic exposure in exfoliated human epithelial cells. Environ Mol

Mutagen 27; 176–184; 1996.

Mujumdar AM, Kapadi AH, Pendse GS. Pharmacological properties. In;

Bavappa KVA, ed., The Areca Nut Palm, Central Plant Crop Research

Institute Publication, 245–261; 1982.

Murray CJ and Lopez AD, eds. The global burden of disease: a

comprehensive assessment of mortality and disability from diseases, injuries

and risk factors in 1990 and projected to 2020. Cambridge, Massachussets:

Harvard School of Public Health, 1996.

Murti PR, Bhonsle RB, Gupta PC Daftary DK, Pindborg JJ, Mehta FS.

Etiology of oral submucous fibrosis with special reference to the role of areca

nut chewing. J Oral Pathol Med 24; 145-152; 1995.

Murti PR, Bhonsle RB, Pindborg JJ, Daftary DK, Gupta PC, Mehta FS.

Malignant transformation rate in Oral Submucous Fibrosis over a 17 year

period. Com Dent Oral Epidemiol 13(6); 340-341; 1985.

189

Murti PR, Daftary DK, Bhonsle RB, Gupta PC, Mehta FS, Pindborg JJ.

Malignant potential of oral lichen planus; observations in 722 patients from

India. J Oral Pathol 15; 71–77; 1986.

Murti PR, Warnakulasuriya KA, Johnson NW, Bhonsle RB, Gupta PC, Daftary

DK, Mehta FS. P53 expression in oral precancer as a marker for malignant

potential. J Oral Pathol Med 27; 191–196; 1998.

Murty VVVS, Mitra AB, Luthra UK, Singh IP. Sister chromatid exchanges in

patients with precancerous and cancerous lesions of cervix uteri. Hum Genet

72; 37-42; 1986.

Nagler RM. Molecular aspect of oral cancer. Anticancer Res 22; 2977-80;

2002.

Nair U, Bartsch H, Nair J. Alert for an epidemic of oral cancer due to use of

the betel quid substitutes gutkha and pan masala; a review of agents and

causative mechanisms. Mutagenesis 19(4); 251–262; 2004.

Nair U, Obe G, Nair J, Maru GB, Bhide SV, Pieper R, Bartsch H. Evaluation of

frequency of micronucleated oral mucosa cells as a marker for genotoxic

damage in chewers of betel quid with or without tobacco. Mutat Res 261;

163–168; 1991.

Nair UJ, Friesen M, Richard I, MacLennan R, Thomas S, Bartsch H. Effect of

lime composition on the formation of reactive oxygen species from areca nut

extract in vitro. Carcinogenesis 11; 2145-48; 1990.

Nakayama J, Yuspa SH, Poirier MC. Benzo(a)pyrene - DNA adduct formation

and removal in mouse epidermis in vivo and in vitro; relationship of DNA

binding to initiation of skin carcinogenesis. Cancer Res 44; 4087-95; 1984.

Natarajan AT and Obe G. Mutagenicity testing with cultured mammalian cells:

cytogenetic assays. In: Mutagenicity: New horizons in Genetic Toxicology.

pp. 171-213. Editors: J.A. Heddle. Academic Press. New York, 1982.

190

Natarajan AT and Obe G. Screening human populations for mutations

induced by environmental pollutants: use of human lymphocytes system.

Ecotoxicol Environ Saf 4; 468 –81; 1980.

National Cancer Registry Programme: Burden and care of cancer patients, a

consolidation report of six hospital cancer registries from 1984 - 1993 under

the Indian Council of Medical Research, New Delhi, Bangalore. Co-ordination

Unit of the NCRP, 1996.

Nelson BS and Heischober B. Betel nut; a common drug used by naturalized

citizens from India, Far East Asia, and the South Pacific Islands. Ann Emerg

Med 34(2); 238-43; 1999.

Nersesyan A, Muradyan R, Kundi M, Knasmueller S. Impact of smoking on

the frequencies of micronuclei and other nuclear abnormalities in exfoliated

oral cells: a comparative study with different cigarette types. Mutagenesis

26(2); 295-301; 2010.

Neslihan AK, Bensu K, Ismet C. Do CYP2A6 and GSTM1 Genotypes have

any Impact on Genotoxicity in Healthy Turkish Smokers? FABAD J Pharm Sci

30; 17-25, 2005.

NFHC: International Institute for Population Sciences and ORC Macro

International. National Family Health Survey (NFHS-3), 2005–06: India, IIPS,

Mumbai, 2007, vol. II, 426–429.

NFHC: International Institute for Population Sciences and ORC Macro,

National Family Health Survey (NFHS-2), 1998–99: India, IIPS, Mumbai,

2000, 41–45.

Nigam P and Srivastava AB. Betel chewing and dental decay. Fed Oper Dent

1(1); 36-38; 1990.

Niphadkar MP, Contractor QQ, Bhisey RA. Mutagenic activity of gastric fluid

from chewers of tobacco with lime. Carcinogenesis 15; 927-931; 1994.

191

Notani PN. Epidemiology and prevention of head and neck cancer: A global

view. In: Saranath D (ed) Contemporary Issues In Oral Cancer, 1–29. Oxford

University Press: New Delhi. 2000.

O¨stling O and Johanson KJ. Microelectrophoretic study of radiationinduced

DNA damages in individual mammalian cells. Biochem Biophys Res Commun

123; 291–298; 1984.

Oesch F, Hengstler JG, Fuchs J. Cigarette smoking protects mononuclear

blood cells of carcinogen exposed workers from additional work exposure

induced DNA single strand breaks. Mutat Res 321; 175–185; 1994.

Oh Y and Mao L. Biomarkers in head and neck carcinoma. Curr Opin Oncol 9;

247-256; 1997.

Olive PL, Banath JP, Durand RE. Detection of etoposide resistance by

measuring DNA damage in individual Chinese hamster cells. J Natl Cancer

Inst 82; 779 –783; 1990.

Ozkul Y, Donmez H, Erenmemisoglu A, Demirtas H, Imamoglu N. Induction of

micronuclei by smokeless tobacco on buccal mucosa cells of habitual users.

Mutagenesis 12; 285–287; 1997.

Pai CY, Hsieh LL, Tsai CW, Chiou FS, Yang CH, Hsu BD. Allelic alterations at

the STR markers in the buccal tissue cells of oral cancer patients and the oral

epithelial cells of healthy betel quid-chewers; an evaluation of forensic

applicability. Forensic Sci Int 129; 158-167; 2002.

Papavasileiou D, Tosios K, Christopoulos P, Goutas N, lachodimitropoulos D.

Her-2 Immunohistochemical Expression in Oral Squamous Cell Carcinomas is

Associated with Polysomy of Chromosome 17, Not Her-2 Amplification. Head

and Neck Pathology 3(4); 263-270; 2009.

Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden;

2000 Globocan. Int J Cancer 94(2); 153–156; 2001.

192

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. Cancer

J Clin 55; 74-108; 2005.

Parkin DM, Whelan SL, Ferlay J, Young J Jr, Raymond L. Cancer incidence in

five continents. IARC Scientific Publication. Lyon. Int Agency for Res on

Cancer 7; 358-361; 1997.

Parmar G, Sagwan P, Vashi P, Kulkarni PK, Kumar S. Tobacco and Areca nut

chewing induces dental attrition and sensitivity. Int J Dent Anthropol 12; 8-14;

2008.

Parry EM, Ulcan H, Wylie FS, Wynford-Thomas D, Parry JM. Segregational

fidelity of chromosomes in human thyroid tumour cells. Chromosoma 107;

491–497; 1998.

Patel BP, Trivedi PJ, Brahmbhatt MM, Shukla SN, Shah PM, Bakshi SR.

Mutagen sensitivity in oral cancer patients, healthy tobacco chewers and

controls. Acta Cytol 54(2);169-74; 2010.

Patel DR and Greydanus DE. Substance abuse; a pediatric concern. Ind J

Pediatr 66; 557-67; 1999.

Patel RK, Jaju RJ, Bakshi SR, Trivedi AH, Dave BJ, Adhvaryu SG. Pan

masala — A genotoxic menace. Mutat Res 320; 245–249; 1994(a).

Patel RK, Trivedi AH, Jaju RJ, Adhvaryu SG, Balar DB. Ethanol potentiates

the clastogenicity of pan masala — An in vitro experience. Carcinogenesis 15,

2017–2021; 1994(b)

Patnaik S, Nayak BK, Das BR. Genetic alterations of P53 in oral tumors. In;

Varma, A.K., ed., Oral Oncology, Vol. VI, Proceedings of the 6th International

Congress on Oral Cancer, New Delhi, Macmillan, 87–92; 1999.

Paymaster JC. Cancer of the buccal mucosa; A clinical study of 650 cases in

Indian patients. Cancer 9; 431-443; 1956.

193

Paz-y-Miño C, Dávalos MV, Sánchez ME, Arévalo M, Leone PE. Should gaps

be included in chromosomal aberration analysis? Evidence based on the

comet assay. Mutat Res 516(1-2); 57-61; 2002.

Perez-Stable EJ, Benowitz NL, Marin G. Is serum cotinine a better measure of

cigarette smoking than self-report? Prev Med 24; 171-9; 1995.

Pillai R, Balram P, Reddiar KS. Pathogenesis of oral submucous fibrosis.

Relationship to risk factors associated with oral cancer. Cancer 69(8); 2011 –

2020; 1992.

Pindborg JJ, Barmes D, Roed-Peterson B. Epidemiology and histology of oral

leukoplakia and leukoedema among Papuans and New Guineans Cancer.

New York 22; 379; 1968.

Pindborg JJ, Bhonsle RB, Murti PR, Gupta PC, Daftary DK, Mehta FS.

Incidence and early forms of oral submucous fibrosis. Oral Surg Oral Med

Oral Path 50(1); 40-45; 1980.

Pindborg JJ, Kiaer J, Gupta PC, Chawla TN. Studies in oral Leukoplakias.

Prevalence of Leukoplakia among 10,0000 persons in Lucknow, India, with

special reference to use of tobacco and betel nut. Bull WHO 37; 109-116;

1967.

Pindborg JJ, Murti PR, Bhonsle RB, Gupta PC, Daftary DK, Mehta FS. Oral

submucous fibrosis as a precancerous condition. Scand J Dent Res 92; 224–

229; 1984.

Pindborg JJ, Reibel J, Roed-Petersen B, Mehta F. Tobacco-induced changes

in oral leukoplakic epithelium. Cancer 45; 2330-36; 1980.

Pinto D, Ceballos JM, Garcia G, Guzman P, Del Razo LM, Vera E, Gomez H,

Garcia A, Gonsebatt ME. Increased cytogenetic damage in outdoors painters.

Mutat Res 467; 105-11; 2000.

194

Pirkle JL, Flegal KM, Bernert JT, Brody DJ, Etzel RA, Maurer KR. Exposure of

the US population to environmental tobacco smoke: the Third National Health

and Nutrition Examination Survey, 1988 to 1991. JAMA 275(16); 1233-1240;

1996.

Poppe B, De Paepe A, Speleman F. Acquired chromosomal rearrangements

targeting selected transcription factors; contribution of molecular cytogenetic

and expression analyses to the identification of clinically and biologically

relevant subgroups in hematological malignancies. Verh K Acad Geneeskd

Belg 69; 47–64; 2007.

Prabhu NT, Warnakulasuriya K, Gelbier S, Robinson PG. Betel quid chewing

among Bangladeshi adolescents living in east London. Int J Paediatric

Dentistry 11(1); 18–24; 2001.

Preber H and Kant T. Effect of tobacco smoking on the periodontal tissues of

15-year-old schoolchildren. J Periodont Res 8; 278-283; 1973.

Preber H, Kant T, Bergstrom J. Cigarette smoking, oral hygiene and

periodontal health in Swedish army conscripts. J Clin Periodontol 7; 106-113;

1980.

Rajendran R and Karunakaran A. Further on causation of oral submucous

fibrosis. Ind J Dent Res 13(2); 74-81; 2002.

Ralhan R, Agarwal S, Nath N, Mathur M, Wasylyk B, Srivastava A. Correlation

between p53 gene mutations and circulating antibodies in betel- and tobacco-

consuming North Indian population. Oral Oncol 37; 243–50; 2001.

Ramesh T, Mendis BR, Ratnatunga N, Thattil RO. The effect of tobacco

smoking and of betel chewing with tobacco on the buccal mucosa; a

cytomorphometric analysis. J Oral Pathol Med 28(9); 385–388; 1999.

Ramirez A and Saldanha PH. Micronucleus investigation of alcoholic patients

with oral carcinomas. Genet Mol Res 1; 246-60; 2002.

195

Ranadive KJ and Gothoskar SV. Betel quid chewing and oral cancer:

experimental studies. In: Prevention and Detection of Cancer. Part I:

Prevention. Vol. 2: Etiology: Prevention Methods, pp. 1745-1766. Editor: H.E.

Nieburgs. Marcel Dekker. New York, 1978.

Ranganathan K, Devi MV, Joshua E, Kirankumar K, Saraswati TR. Oral

submucous fibrosis: a case-control study in Chennai, South India. J Oral

Pathol Med 35; 274-277; 2004.

Rani M, Bonu S, Jha P, Nguyen SN, Jamjoum L. Tobacco use in India;

prevalence and predictors of smoking and chewing in a national cross

sectional household survey. Tob Control 12(4); 2003.

Rashmi S, Ravindra Ti, Penagaluru PR, Yog RA. Risk assessment of oral

cancer in patients with pre-cancerous states of the oral cavity using

micronucleus test and challenge assay. Oral Oncology 44(4); 354-360; 2008.

Ray MR, Basu C, Mukherjee S, Roychowdhury S, Lahiri T. Micronucleus

frequencies and nuclear anomalies in exfoliated buccal epithelial cells of

Firefighters. Int J Hum Genet 5(1); 45-48; 2005.

Reddy KS and Gupta, PC. Prevalence of tobacco use among the youth. In

Report on Tobacco control in India (eds), Ministry of Health and Family

Welfare, Government of India, pp. 61–67; 2004.

Reddy KS, Perry CL, Stigler MH, Arora M. Differences in tobacco use among

young people in urban India by sex, socioeconomic status, age, and school

grade: assessment of baseline survey data. Lancet 367; 589–594; 2006.

Reddy MS, Naik SR, Bagga OP, Chuttani HK. Effect of chronic tobacco-betel-

lime ‘quid’ chewing on human salivary secretions. Am J Clin Nutr 33; 77–80;

1980.

Reichart P and Gehring F. Streptococcus mutans and caries prevalence in

Lisu and Karen of northern Thailand. J Dent Res 63(1); 56-58; 1984.

196

Repace JL and Lowrey AH. An enforceable indoor air quality standard for

environmental tobacco smoke in the workplace. Risk Anal 13; 463-75; 1993.

Riegman PH, Vissers KJ, Alers JC, Geelen E, Hop WC, Tilanus Hw, van

Dekken H. Genomic alterations in malignant transformation of Barrett’s

eosphagus. Cancer Res 61; 3164–70; 2001.

Roberts D. Comparative cytology of the oral cavities of snuff users. Acta Cytol

41; 1008–1014; 1997.

Rosin MP. The use of the micronucleus test on exfoliated cells to identify anti-

clastogenic action in humans; a biological marker for the efficacy of

chemopreventive agents. Mutat Res 267; 265–276; 1992.

Roy B, Beamon J, Balint E, Reisman D. Transactivation of the human p53

tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53

expression in some tumors. Mol Cell Biol 14; 7805–15; 1994.

Rupa DS and Eastmond DA. Chromosomal alterations affecting the 1cen-

1q12 region in buccal mucosal cells of betel quid chewers detected using

multicolor fluorescence in situ hybridization. Carcinogenesis 18; 2347–2351;

1997.

Saatci C, Ozkul Y, Tahiri S, Caglayan AO, Turhan AB, Dundar M. The effect

of maras powder on DNA methylation and micronucleus formation in human

buccal tissue. J Toxicol Environ Hlth A 71(6); 396-404; 2008.

Sakai E and Tsuchida N. Most human squamous cell carcinomas in the oral

cavity contain mutated p53 tumor-suppressor genes. Oncogene 7(5); 927–

933; 1992.

Sanghvi LD. Cancer epidemiology: the Indian scene. J Cancer Res Clin Oncol

99; 1-14; 1981.

Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R, Thara S, Mathew

B, Rajan B. Effect of screening on oral cancer mortality in Kerala, India: a

197

cluster-randomised control trial. Trivandrum Oral Cancer Screening Study

Group. Lancet 365; 1927-1933; 2005.

Saranath D, Chang SE, Bhoite LT, Panchal RG, Kerr IB, Mehta AR, Johnson

NW, Deo MG. High frequency mutation in codons 12 and 61 of H-ras

oncogene in chewing tobacco-related human oral carcinoma in India. Br J

Cancer 63; 573–578; 1991.

Saranath D, Tandle AT, Teni TR, Dedhia PM, Borges AM, Parikh D, Sanghavi

V, Mehta AR. p53 Inactivation in chewing tobacco-induced oral cancers and

leukoplakias from India. Oral Oncol 35; 242–250; 1999.

Sardas S, Cimen B, Karsli S, Yurdun T, Donbak L. Comparison of genotoxic

effect between smokeless tobacco (Maras powder) users and cigarette

smokers by the alkaline comet assay. Hum Exp Toxicol 28(4); 214-219;

2009.

Sardas S, Walker D, Akyol D, Karakaya AE. Assessment of smoking-induced

DNA damage in lymphocytes of smoking mothers of newborn infants using

the alkaline single-cell gel electrophoresis technique. Mutat Res 335; 213-

217; 1995.

Sasano H, Goukon Y, Nishihira T, Nagura H. In situ hybridization and

immunohistochemistry of p53 tumor suppressor gene in human esophageal

carcinoma. Am J Pathol 141(3); 545-50; 1992.

Schamschula RG, Adkins BL, Barmes DE, Charlton G. Betal chewing and

caries experience in New Guinea. Community Dent Oral Epidemiol 5(6); 284-

286; 1977.

Schantz SP. Carcinogenesis, markers, staging, and prognosis of head and

neck cancer. Curr Opin Oncol 5; 483-490; 1993.

Schatzkin A, Freedman LS, Schiffman MH, Dawsey SJ. Validation of

intermediate endpoints in cancer research. JNCI 82; 1746- 1752; 1990.

198

Schmid W. The micronucleus test. Mutat Res 31; 9–15; 1975.

Schwartz D, Almong N, Peled A, Goldfinger N, Rotter V. Role of wild type p53

in the G2 phase: regulation of the γ-irradiation induced delay and DNA

repair. Oncogene 15; 2597–2607; 1997.

Scientific Committee on Emerging and Newly Identified Health Risks

(SCENIHR), European Commision, Health Effects of Smokeless Tobacco

Products Preliminary Report, 2007.

Scott KC and Turnland JR. A compartmental model of zinc metabolism in

adult man to study effects of three levels of dietary copper. Am J Physiol 267;

E165-E173; 1994.

Seedat HA and Van Wyk CW. Betel-nut chewing and submucous fibrosis in

Durban. S Afr Med J 74; 568–571; 1988.

Sellappa S, Balakrishnan M, Raman S, Palanisamy S. Induction of micronuclei

in buccal mucosa on chewing a mixture of betel leaf, areca nut and tobacco. J

Oral Sci 51(2); 289-92; 2009(a).

Sellappa S, Balakrishnan M, Vellingiri B. Mixture of betel leaf, areca nut and

tobacco chewing is a risk factor for cytogenetic damage in construction

workers from south India. Brazilian J Oral Sciences 8(3); 145-148; 2009(b).

Sellappa S, Prathyumnan S, Joseph S, Keyan KS, Balakrishnan M, Sasikala

K. XRCC1399 and hOGG1326 polymorphisms and frequencies of

micronuclei, comet and chromosomal aberrations among tobacco chewers; a

South Indian population study. Asian Pac J Cancer Prev 10(6); 1057-62;

2009(b).

Shah N, Kumar R, Shah MK. Immunological studies in oral submucous

fibrosis. Ind J Dent Res 5; 81-87; 1994.

199

Shah SM, Merchant AT, Luby SP, Chotani RA. Addicted schoolchildren;

prevalence and characteristics of areca nut chewers among primary school

children in Karachi, Pakistan. J Paediatr Child Hlth 38; 507-10; 2002.

Shahnavaz SA, Ragezi JA, Bradley G, Dube IW, Jordan RC. P53 gene in

mutations sequential oral epithelial dysplasias and squamous cell carcinomas.

The J Pathol 190; 417–22; 2000.

Shetty KV and Johnson NW. Knowledge, attitudes and beliefs of adult South

Asians living in London regarding risk factors and signs for oral cancer.

Commun Dent Hlth 16(4); 227–231; 1999.

Shiau Y and Kwan H. Submucous fibrosis in Taiwan. Oral Surg Oral Med Oral

Path 47; 453-457; 1979.

Shiu and Chen. Impact of betel quid, tobacco and alcohol on three-stage

disease natural history of oral leukoplakia and cancer: Implication for

prevention of oral cancer. Eur J Cancer Prev 13(1); 39-45; 2004.

Silverman S. Oral cancer. 5th ed. American Cancer Society. Hamilton

(Ontario, Canada); BC Decker, Inc.; 2003. p. 212.

Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for

quantitation of low levels of DNA damage in individual cells. Exp Cell Res

175; 184 – 191; 1988.

Sinor PN, Gupta PC, Murti PR, Bhonsle RB, Daftary DK, Mehta FS, Pindborg

JJ. A case–control study of oral submucous fibrosis with special reference to

the etiologic role of areca nut. J Oral Pathol Med 19; 94–98; 1990.

Sisting S, Boras evi V Vu I, Luka J, Kusi Z. Salivary IgA and IgG subclasses

in oral mucosal diseases. Oral Dis 8(6); 282-6; 2002.

Smith AH, Hopenhayn-Rich C, Warner M, Biggs ML, Moore L, Smith MT.

Rationale for selecting exfoliated bladder cell micronuclei as potential

biomarkers for arsenic genotoxicity. J Toxicol Environ Hlth 40; 223-234; 1993.

200

Smith LW, Bhargawa K, Mani NJ, Malaowalla AM, Silverman S Jr. Oral

cancer and precancerous lesions in 57,518 industrial workers of Gujarat,

India. Cancer 12; 118-23; 1975.

Somorovska M, Szabova E, Vodicka P, Tulinska J, Barancokova M, Fabri R,

Liskova A, Riegerova Z, Petrovska H, Kubova J, Rausova K, Dusinska M,

Collins A. Biomonitoring of genotoxic risk in workers in a rubber factory,

comparison of the Comet assay with cytogenetic methods and immunology,

Mutat Res 445; 181– 192; 1999.

Speit G and Hartmann A. The contribution of excision repair to the DNA

effects seen in the alkaline single cell gel test (comet assay). Mutagenesis 10;

555–559; 1995.

Spivack SD, Hurteau GJ, Jain R, Kumar SV, Aldous KM, Gierthy JF,

Kaminsky LS. Gene-environment interaction signatures by quantitative mRNA

profiling in exfoliated buccal mucosal cells. Cancer Res 64; 6805-13; 2004.

Stich HF and Anders F. The involvement of reactive oxygen species in oral

cancers of betel quid/tobacco chewers. Mutat Res 214; 47–61; 1989.

Stich HF and Dunn BP. Relationship between cellular levels of beta-carotene

and sensitivity to genotoxic agents. Int J Cancer 38; 713–717; 1986.

Stich HF and Rosin MP. Quantitating the synergistic effect of smoking and

alcohol consumption with the micronucleus test on human buccal mucosa

cells. Int J Cancer 31; 305–308; 1983.

Stich HF and Stich W. Chromosome damaging activity of saliva of betel nut

and tobacco chewers. Cancer Letters 15; 193-202; 1982.

Stich HF, Curtis JR, Parida BB. Application of the micronucleus test to

exfoliated cells of high cancer risk groups; tobacco chewers. Int J Cancer 30;

553–559; 1982(a).

201

Stich HF, Stich W, Parida BB. Elevated frequency of micronucleated cells in

the buccal mucosa of individuals at high risk for oral cancer; betel quid

chewers, Cancer Lett 17; 125–134; 1982(b).

Stich HF, Mathew B, Sankaranarayanan R, Nair MK. Remission of

precancerous lesions in the oral cavity of tobacco chewers and maintenance

of the protective effect of β-carotene or vitamin A. Am J Clin Nutr 53; 298–

304; 1991.

Stich HF, Ohshima H, Pignatelli B, Michelon J, Bartsch H. Inhibitory effect of

betel nut extracts on endogenous nitrosation in humans. J Natl Cancer Inst

70; 1047–1050; 1983.

Stich HF, Parida BB, Brunnemann KD. Localized formation of micronuclei in

the oral mucosa and tobacco-specific nitrosamines in the saliva of ‘reverse’

smokers, khaini tobacco chewers and gudakhu users. Int J Cancer 50; 172–

176; 1992.

Stich HF, Rosin MP, Hornby AP, Mathew B, Sankarayanan R, Nair MK.

Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers

treated with beta-carotene and with beta-carotene plus vitamin A. Int J Cancer

42; 195–199; 1988.

Stratton KS, Wallace R, Bondurant S. Clearing the smoke: the science base

for tobacco harm reduction-executive summary. Tob Control 10; 189-95;

2001.

Subapriya R, Thangavelu A, Mathavan B, Ramachandran CR, Nagini S.

Assessment of risk factors for oral squamous cell carcinoma in Chidambaram,

Southern India; a case-control study. Eur J Cancer Prev 16(3); 251–256;

2007.

Sundqvist K, Liu Y, Erhardt P, Nair J, Bartsch H, Grafström RC. Areca nut

toxicity in cultured human buccal epithelial cells. IARC Sci Publ 105; 281-285;

1991.

202

Surrallés J, Antoccia A, Creus A, Degrassi F, Peris F, Tanzarella C, Xamena

N, Marcos R. The effects of cytochalasin-B concentration on the frequency of

micronuclei induced by four standard mutagens. Results from two

laboratories. Mutagenesis 9; 347–353; 1994.

Tanaka T, Mori H, Fujii M, Takahashi M, Hironol I. Carcinogenicity

examinationof betel quid II. Effect of vitamin A deficiency on rats fed

semipurified diet containing betel nut and calcium hydroxide. Nutr Cancer 4;

260-266; 1983.

Tang JG, Jian XF, Gao ML, Ling TY, Zhang KH. Epidemiological survey of

oral submucous fibrosis in Xiangtan City, Hunan Province, China. Commun

Dent Oral Epidemiol 25; 177–180; 1997.

Tariq P. Foreign body aspiration in children--a persistent problem. J Pak Med

Assoc 49; 33-6; 1999.

Taybos G. Oral changes associated with tobacco use. Am J Med Sci 326; 179

– 82; 2003.

Taylor A. Detection and monitoring for disorders of essential trace elements.

Annals Clin Biochem 33; 486-510; 1996.

The Assessment of Mutagenicity. Health Protection Branch Mutagenicity

Guidelines. Health Protection Branch Genotoxicity Committee, Department of

National Health and Welfare, Canada. Environ Mol Mutagen. 1993; 21(1):15-

37; discussion 46-57.

Thomas P, Holland N, Bolognesi C, Micheline Kirsch-Volders, Bonassi S,

Zeiger E, Knasmueller S, Fenech M. Buccal micronucleus cytome assay.

Nature Protocol 4 (6); 285-237; 2009.

Thompson SG, Stone R, Nanchahal K, Wald NJ. Relation of urinary cotinine

concentrations to cigarette smoking and to exposure to other people's smoke.

Thorax 45; 356-61; 1990.

203

Tice RT. The single cell gel/Comet assay: a microgel electrophoretic

technique for the detection ofDNAdamage and repair in individual cells, in:

D.H. Phillips, S.Venitt (Eds.), Environmental Mutagenesis, Bios Scientific

Publishers LTD, Oxford, UK, 1995.

Tolbert PE, Shy CM, Allen JW. Micronuclei and other nuclear anomalies in

buccal smears; Field tests in snuff users. Am J Epidemiol 134; 840–850;

1991.

Tolbert PE, Shy CM, Allen JW. Micronuclei and other nuclear anomalies in

buccal smears; Methods development. Mutat Res 271; 69-77; 1992.

Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer.

FEBS Lett 358; 1-3; 1995.

Tricker AR. Nicotine metabolism, human drug metabolism polymorphisms,

and smoking behaviour. Toxicology 183; 151–73; 2003.

Tricker AR and Preussmann R. The occurrence of N-nitro compounds in

zarda tobacco. Cancer Lett 42; 113–118; 1988.

Trivedi AH, Balar DB, Shah PM, Patel DD, Patel RK, Bakshi SR, Dinavahi

VBR. Carcinogenic and genotoxic effects of the tobacco substitute pan

masala: present status and likely future impact on the Indian population.

Cancer Treat Rev 22(5); 345-54; 1996.

Trivedi AH, Roy SK, Patel RK, Adhvaryu SG, Balar DB. Urine of

tobacco/areca nut chewers causes genomic damage in Chinese hamster

ovary cells. Carcinogenesis 16; 205–208; 1995.

Trivedy C, Warnakulasuriya S, Peters TJ. Areca nuts can have deleterious

effects. Br Med J 318(8); 1287; 1999.

Trivedy C, Baldwin D, Warnakalasuriya S, Johnson N, Peters TJ. Copper

content in areca catechu (betel nut) products and oral submucous fibrosis.

Lancet 349; 1447; 1997.

204

Trivedy C, Meghji S, Warnakulsuriya KA, Johnson NW, Harris M. Copper

stimulation in oral fibroblast in vitro: a role in pathogenesis of oral submucous

fibrosis. J Oral Pathol Med 30(8): 465-470; 2001.

Trivedy C, Warnakulasuriya S, Hazarey VK, Johnson NW. The role of copper

in the aetiopathogenesis of oral submucous fibrosis. In Verma A K, ed. Oral

Oncol IV. McMillan Press, New Delhi; 7-10; 1999.

Trivedy C, Warnakulasuriya KAAS, Peters TJ, Senkus R, Hazarey VK,

Johnson NW. Raised copper levels in tissue in oral submucous fibrosis. J Oral

Pathol Med 29; 241-248; 2000.

Trivedy C, Warnakulasuriya KAAS, Tavassoli M, Steingrimsdottir H,

Penhallow J, Maher R, Johnson NW. p53 Aberrations in oral submucous

fibrosis and oral squamous cell carcinoma detected by immunocytochemistry

and PCR-SSCP. J Oral Pathol Med 27; 72–77; 1998.

Trivedy CR, Craig G, Warnaklsuriya S. Areca nut symposium. The oral health

consequences of chewing areca nut. Addiction Biology 7(1); 115-125; 2002.

Tsai JF, Jeng JE, Chuang LY, Ho MS, Ko YC, Lin ZY, Hsieh MY, Chen SC,

Chuang WL, Wang LY, Yu ML, Dai CY, Ho C. Habitual betel quid chewing as

a risk factor for cirrhosis: a case-control study. Medicine (Baltimore); 82(5);

365-372; 2003.

Underwood. General and Systemic Pathology. 4th Edition. Edinburgh,

London; Churchill Livingstone 2004.

Vaglenov A, Nosko M, Georgieva R, Carbonell E, Creus A, Marcos R.

Genotoxicity and radioresistance in electroplating workers exposed to

chromium. Mutat Res 446; 23–34; 1999.

Van Wyk CW, Stander I, Padayachee A, Grobler­Rabie AF. The areca nut

chewing habit and oral squamous cell carcinoma in South African Indians. A

retrospective study. S Afr Med J 83; 425­9; 1993.

205

Varghese I, Sugathan CK, Balasubramoniyan G and Vijayakumar T. Serum

copper and zinc levels in premalignant and malignant lesions of the oral

cavity. Oncology 4(4); 224-227; 1987.

Vasavi M, Vedicherala B, Vattam KK, et al. Assessment of genetic damage in

inflammatory, precancerous and cancerous pathologies of the esophagus

using the comet assay. Genet Test Mol Biomarkers 14(4); 477-82; 2010.

Vogelstein B and Kinzler KW. p53 function and dysfunction. Cell 70; 523–526;

1992.

Vogelstein B, Fearon ER, Hamilton SR, Kem SE, Preisinger AC, Leppert

M, Nakamura Y, White R, Smits AMM, Bos JL. Genetic alterations during

colorectal-tumour development. N Engl J Med 319; 525-532; 1988.

Vondracek M, Xi Z, Larsson P, Baker V, Mace K, Pfeifer A, Tjalve H, Donato

MT, Gomez-Lechon MJ, Grafstrom RC. Cytochrome P450 expression and

related metabolism in human buccal mucosa. Carcinogenesis 22; 481–488;

2001.

Vora AR, Yeoman CM, Hayter JP. Alcohol, tobacco and paan use and

understanding of oral cancer risk among Asian males in Leicester. Bri Dent J

188(8); 444–451; 2000.

Waerhaug J. Prevalence of periodontal diseases in Ceylon. Final Report. Acta

Odont Scand 25; 205-231; 1967.

Wahi PN, Mittal VP, Lahiri B, Luthra UK, Seth RK, Arora GD. Epidemiological

study of precancerous lesions of the oral cavity; A preliminary report. Ind J

Med Res 58; 1361-1391; 1970.

Wang SC, Tsai CC, Huang ST, Hong YJ. Betel nut chewing and related

factors in adolescent students in Taiwan. Public Health 117(5); 339-345;

2003.

206

Wang YC, Lee HS, Chen SK, Chang YY, Chen CY. Prognostic significance of

p53 codon 72 polymorphism in lung carcinomas. Eur J Cancer 35; 226–30;

1999.

Warnakulasuriya S. The role of betel-quid in oral carcinogenesis. In; Betel-

quid and tobacco chewing among the Bangladeshi community in the United

Kingdom. London; Centre for Transcultural Health. Bedi R, Jones P, editors;

61-69; 1995.

Warnakulasuriya S. Areca nut use following migration and its consequences.

Addiction Biol 7(1); 127–132; 2000.

Warnakulasuriya S and Peters TJ. Special section: Areca nut symposium.

Introduction, biology, medical and socioeconomic aspects of areca nut use.

Addiction Biol 7; 75-76; 2002.

Warnakulasuriya S, Trivedy C, Peters TJ. Areca nut use: an independent risk

factor for oral cancer. BMJ 324 (7341); 799-800; 2002.

Wary KK and Sharan RN Aqueous extract of betel-nut of North-east India

induces DNA-strand breaks and enhances rate of cell proliferation in vitro. J

Cancer Res Clin Oncol 114; 579-582; 1988.

Wenke G, Brunnemann KD, Hoffmann D, Bhide SV. A study of betel quid

carcinogenesis. IV. Analysis of the saliva of betel chewers; a preliminary

report. J Cancer Res Clin Oncol 108; 110–113; 1984 (a).

Wenke G, Rivenson A, Brunnemann KD, Hoffmann D, Bhide SV. A study of

betel quid carcinogenesis. II. Formation of N-nitrosamines during betel quid

chewing. IARC Sci Publ 859–866; 1984 (b).

Wenke G, Rivenson A, Hoffmann D. A study of betel quid carcinogenesis. 3 3-

(Methylnitrosamino)- propionitrile, a powerful carcinogen in F344 rats.

Carcinogenesis 5; 1137–1140; 1984 (c).

207

WHO collaborating centre for oral precancerous lesions. Definition of

Leukoplakia and related lesions: An aid to studies on precancer. Oral Surg

Oral Med Oral Path 46; 517-539; 1978.

WHO. Controlling the smoking epidemic. Report of the WHO Expert

Committee on Smoking Control, Technical Report Series 630, WHO, Geneva

1979.

WHO. Control of oral cancer in developing countries. A WHO meeting. Bull

World Health Org 62; 817-830; 1984.

WHO. Smokeless tobacco control. Report of a WHO study group. Technical

report series. 773, Geneva, 1988.

WHO. World Health Organization; Making a Difference. In World Health

Report World Health Organization; Geneva; 1999.

WHO. The World Health Report. Reducing risk, promoting healthy life. WHO

Geneva pp.1-248; 2002

WHO. World cancer report. Stewart BW, Kleihues P, editors. Lyon (France);

WHO, IARC Press; p. 352; 2003.

WHO. Report on the global tobacco epidemic, 2008 (foreword and summary).

"Tobacco is the single most preventable cause of death in the world today". 8;

2008.

wikipedia; www.en.wikipedia.org/wiki/Leukoplakia

Williams JA, Wang ZR, Parrish RS, Hazlett LJ, Smith ST, Younga SR.

Fluorescence in Situ Hybridization Analysis of HER-2/neu, c-myc, and p53 in

Endometrial Cancer. Expt Moler Pathol 67(3); 135-143; 1999.

Williams SA, Summers RM, Ahmed IH, Prendergast MJ. Caries experience

tooth loss and oral health related behaviors among Bangladeshi women

resident in West Yorkshire, UK. Commun Dent Health 13; 150-156; 1996.

208

Winstock A. Areca nut-abuse liability, dependence and public health. Addict

Biol 7; 133–138; 2002.

Winstock AR, Trivedy CR, Warnakulasuriya KAAS, Peters TJ. A dependency

syndrome related to areca nut use; some medical and psychological aspects

among areca nut users in the UK. Addicti Biol 5; 173–179; 2000.

Wolfe MD and Carlos JP. Oral health effects of smokeless tobacco use in

Navajo Indian adolescents. Commun Dent Oral Epidemiol 15; 230-235; 1987.

Wu PA, Loh CH, Hsieh LL, Liu TY, Chen CJ, Liou SH. Clastogenic effect for

cigarette smoking but not areca quid chewing as measured by micronuclei in

exfoliated buccal mucosal cells. Mutat Res 8; 27-38; 2004.

Wu TT, Watanabe T, Heitmiller R, Marianna I, Arlene AF, Stanley RH.

Genetic alterations in Barrett esophagus and adenocarcinomas of the

esophagus and esophagogastric junction region. Am J Pathol. 153; 287–94;

1998.

Wu X, Zhao H, Amos CI, Shete S, Makan N, Hong WK, Kadlubar FF, Spitz

MR. Lung cancer susceptibility associated with p53 genotypes and haplotypes

in various ethnic groups. J Natl Cancer Inst 94; 681–690; 2002.

Wyllie A. Cell death: a new classification separating apoptosis from necrosis.

In: Cell Death in Biology and Pathology (Bowen, I. and Lockshin R., eds.).

Chapman and Hall, London, England, 1-34; 1981.

Xu J, Gimenez-Conti IB, Cunningham JE, Collet AM, Luna MA, Lanfranchi

HE, Spitz MR, Conti CJ. Alterations of p53, cyclin D1, Rb and H-ras in human

oral carcinomas related to tobacco use. Cancer 83; 204–12; 1998.

Yadav JS and Chadha P. Genotoxic studies in Pan masala chewers: A high

cancer risk group. Int J Hum Genet 2(2); 107-112; 2002.

Yang JA, Huber SA, Lucas ZJ. Inhibition of DNA synthesis in cultured

lymphocytes and tumor cells by extracts of betel nut, tobacco and miang leaf,

209

plant substances associated with cancer of the ororespiratory epithelium.

Cancer Res 39, 4802–4809; 1979.

Yang MS, Chang FT, Chen SS, Lee CH, Ko YC. Betel quid chewing and risk

of adverse pregnancy outcomes among aborigines in southern Taiwan. Public

Health 113, 189–192; 1999.

Yeh CG. Fatigue root fracture; a spontaneous root fracture in non-

endodontically treated teeth. Br Dent J 182; 261-66; 1997.

Yildiz D, Liu YS, Ercal N, Armstrong DW. Comparison of pure nicotine- and

smokeless tobacco extract-induced toxicities and oxidative stress. Arch

Environ Contam Toxicol 37; 434–439; 1999.

Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-type p53 restores

cell cycle control and inhibits gene amplification in cells with mutant p53

alleles. Cell 70(6); 937-48; 1992.

Yokota J, Wada M, Shimosato Y, Terada M, Sugimura T. Loss of

herozygosity on chromosomes 3, 13 and 17 in small-cell carcinoma and on

chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci USA 84;

9252-56; 1987.

Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-

type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by

interleukin-6. Nature 352; 345-47; 1991.

Yoshida S. Study on the deficiency of trace element induced by aging. Part II.

Effects of zinc deficiency on rats oral mucosa. Nippon Hotetsu Shika Gakkai

Zasshi 33(2); 376-390; 1989.

Yunus M and Khan Z. A baseline study of tobacco use among the staff of

Aligarh Muslim University, Aligarh, India. J R Soc Hlth 117(6); 359-365; 1997.

210

Zain RB, Ikeda N, Razak IA, Axéll T, Majid ZA, Gupta PC, Yaacob M. A

national epidemiological survey of oral mucosal lesions in Malaysia.

Community Dent. Oral Epidemiol 25; 377–383; 1997.

Zain RB. Oral mucosal lesions associated with betel quid, areca nut and

tobacco chewing habits: consensus from a workshop held in Kuala Lumpur,

Malaysia. J Oral Pathol Med 28; 1-4; 1999.

Zevin S, Jacob III P, Geppeti P, Benowitz NL. Clinical pharmacology of oral

cotinine. Drug Alcohol Depend 60; 13–18; 2000.

Zhan Q, Bae I, Kastan MB, Fornace AJ Jr. The p53-dependent gamma-ray

response of GADD45. Cancer Res 54(10); 2755-60; 1994.