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TRANSCRIPT
1H NMR Spectrum of 1 at 600 MHz in CDCl3
M56-KT-76_1H-CDCl3-pw90_09062013
7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
Chemical Shift (ppm)
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
Ab
so
lute
In
ten
sity
28
26
25
5'22
131314
10
3'1515
12
23
27
6'
29
6 11
NH27
1'
5
94'34
19
Electronic Supplementary Material (ESI) for Chemical Science.This journal is © The Royal Society of Chemistry 2014
HSQC Spectrum of 1 at 600 MHz in CDCl3
7 6 5 4 3 2 1 0
F2 Chemical Shift (ppm)
0
20
40
60
80
100
120
140
F1
Ch
em
ica
l S
hift
(pp
m)
C-19
C-4'
C-15
C-5'
C-1'
C-3'
C-6'
COSY Spectrum of 1 at 600 MHz in CDCl3
8 7 6 5 4 3 2 1 0
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
7
F1
Ch
em
ica
l S
hift
(pp
m)
H-3'/H-4' H-4'/H-5'
TOCSY Spectrum of 1 at 600 MHz in CDCl3
7 6 5 4 3 2 1
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
7
8
F1
Ch
em
ica
l S
hift
(pp
m)
H-3'/H-4' H-4'/H-5'
HMBC Spectrum of 1 at 600 MHz in CDCl3
7 6 5 4 3 2 1
F2 Chemical Shift (ppm)
0
50
100
150
200
F1
Ch
em
ica
l S
hift
(pp
m)
H-5'/C-4'
H-5'/C-3'
H-1'/C-21
H-1'/C-6'
H-3'/C-2'
H-3'/C-4'
H-6'/C-1'
Expanded HMBC Spectrum of 1 at 600 MHz in CDCl3
6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0
F2 Chemical Shift (ppm)
130
135
140
145
F1
Ch
em
ica
l S
hift
(pp
m)
3.0 2.5 2.0
F2 Chemical Shift (ppm)
196
198
200
202
204
206
208
F1
Ch
em
ica
l S
hift
(pp
m)
H-1'/C-21
H-3'/C-2'
H-15/C-16
H-15/C-17
H-15/C-21
H-29/C-17
H-19/C-20
H-19/C-21
H-19/C-17
1H NMR Spectrum of 1 at 600 MHz in CD3OD
M56-KT-29_1H-CD3OD-pw90_06052013
7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
Chemical Shift (ppm)
0.05
0.10
0.15
0.20
0.25
Norm
aliz
ed I
nte
nsity
19
4 3 4'9
5
1'
7 6
29
6'
11
27
23
15 15
12
3'
1014
22
13
13
5'
25
26
28
HSQC Spectrum of 1 at 600 MHz in CD3OD
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5
F2 Chemical Shift (ppm)
0
20
40
60
80
100
120
140
F1
Ch
em
ica
l S
hift
(pp
m)
C-19
C-4'
C-1'
C-6'
C-15
C-3'
C-5'
COSY Spectrum of 1 at 600 MHz in CD3OD
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
7
F1
Ch
em
ica
l S
hift
(pp
m)
H-3'/H-4' H-4'/H-5'
TOCSY Spectrum of 1 at 600 MHz in CD3OD
6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
7
F1
Ch
em
ica
l S
hift
(pp
m)
H-3'/H-4' H-4'/H-5'
HMBC Spectrum of 1 at 600 MHz in CD3OD
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
F2 Chemical Shift (ppm)
0
50
100
150
200
F1
Ch
em
ica
l S
hift
(pp
m)
H-1'/C-6'
H-1'/C-21
H-6'/C-1'
H-5'/C-3'
H-5'/C-4'
H-3'/C-2'
H-3'/C-4'
H-19/C-20
H-19/C-21
H-19/C-17 H-29/C-17
ROESY Spectrum of 1 at 600 MHz in CD3OD
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
F1
Ch
em
ica
l S
hift
(pp
m)
H-4/H-22
H-3/H-6
H-7/H-9
H-10/H-25
1H NMR Spectrum of 8 at 600 MHz in CD3OD
M56-KT-28_1H-CD3OD-pw90_05062013
7.5 7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
Chemical Shift (ppm)
0.05
0.10
0.15
Norm
aliz
ed I
nte
nsity
1943
95
76
1-OCH3
11
27
23
15
1210 14
22 25
13 13
26 28
HSQC Spectrum of 8 at 600 MHz in CD3OD
7 6 5 4 3 2 1 0
F2 Chemical Shift (ppm)
0
20
40
60
80
100
120
140
F1
Ch
em
ica
l S
hift
(pp
m)
C-19
C-15
C-7
OCH3
TOCSY Spectrum of 8 at 600 MHz in CD3OD
8 7 6 5 4 3 2 1 0
F2 Chemical Shift (ppm)
0
1
2
3
4
5
6
7
F1
Ch
em
ica
l S
hift
(pp
m)
HMBC Spectrum of 8 at 600 MHz in CD3OD
8 7 6 5 4 3 2 1
F2 Chemical Shift (ppm)
0
50
100
150
F1
Ch
em
ica
l S
hift
(pp
m)
OCH3/C-1
H-7/C-24
H-15/C-16
H-15/C-17
H-15/C-21