08 a finestra
TRANSCRIPT
4TH MERIAL FORUM
HAVE WE GOT PCVD &
SWINE INFLUENZA UNDER
CONTROL?
PCVD session 3
Moderator: Dr Thaïs Vila
• PCVD in 2012: a special focus on sub clinical forms, Pr. J. Segalés
• CIRCOVAC piglet vaccination: successful field experience in Spain, Dr A. Finestra
• PCVD control in 2012: how to design the best PCV2 vaccination programme? Drs F. Smeets & G. Perreul
CIRCOVAC piglet vaccination:
successful field experience in
Spain
Albert Finestra
tsc
Le Borges Blanques-Lleida
Summary
• Self-introduction
• Farm description
• Why did we decide to start vaccination?
– Evolution of the production parameters
– Diagnosis of PMWS
• Impact of the vaccination
• Conclusions
Who am I, and where I come from?
• tsc is a consultancy funded in 2004 by two swine
specialist vets.
• We are devoted to:
– Optimize the efficiency of pig farms
– Design and implement disease eradication programs
both at farm, region or nation level
– Giving advice on pig feeding and nutrition.
– Design and implement field trials. We also own an
experimental fattening unit of 350 pig capacity.
Company description
• They had 2400 sows in 3 farms:
– 550 GP sows in Ginestar (Tarragona) to produce F1
for their farms and external sales
– Owned 600 and 1250 production sows in Arbeca
(Lleida)
• Also have Feed mill to elaborate their feeds
• Fatteners: 5500 heads and other with 7500 pigs
• owned fatteners and sow units work with liquid food (a
mix of feed and by-products)
• Others fatteners are integrated
Farm description
• 2 site production 600 sows farrow-to-finish farm
• Batch farrowing on a weekly base
– About 300 pigs weaned/week
• Fattening unit 500 m apart from Site 1+2
• Batch size: about 600 animals
• Wet feeding based on by-products
Sow farm I: sites 1+2
Feed mill Kitchen-wet feeding
Sow farm and nurseries
Piglet management
• Weaning age: 24-25 days (Wednesdays)
• Piglets are left in the farrowing unit an
additional week.
• Post-weaning: 32-33 days
• Age at starting of fattening: 60-61 days
Finishers
Feed mill
Fattening unit
Olive trees
Yearly evolution of some
production parameters Yearly evolution of some of the production parameters in fattening
2,410
2,250
2,290
2,190
2,160
2,210
2,280
2,2502,240
2,300
0
1
2
3
4
5
6
7
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
Year
% l
osses/€
2,000
2,050
2,100
2,150
2,200
2,250
2,300
2,350
2,400
2,450
FC
R (
kg
/kg
)
% losses
Medication cost (€)
FCR (kg/kg)
April 07 New genetic
line
Circovac
Started new Vet in the company Oct 2007
Why vaccination? • In April 07 a new genetic line was introduced in
the system. It had an obvious sanitary impact.
2 2,1
6,9 7,1
1,9
Mortalidad
Mortality evolution
2006 1 sem 2007 2 sem 2007 1 sem 2008 2 sem 2008
Why vaccination? • In April 07 a new genetic line was introduced in
the system. It had an obvious sanitary impact.
Health impact
• We progressively observed:
– An increase of the mortality rate from an average of
3% to a peak of 9%
– The need to treat more animals
– Less efficay of the antibiotic treatments
– A negative impact on the homogeneity of the group
• As we suspected PMWS, we decided to submit
some animals to the diagnosis lab: UAB/CReSA
Facilities
Facilities
Clinical signs
Clinical signs
Clinical signs
Lesions at necropsy
Gastric ulcers
Diagnosis Table 1.- Summary of the laboratory report of the first samples sent to the UAB (November 2007)
Sample Microscopic
lesions1
ISH for PCV2 Remarks
1 Mild to moderate (LN) or moderate
(T) lymphoid depletion
Low to moderate amount of PCV2
genome
Subclinical PCV2 infection+ Diarrhoea
2 Mild lymphoid depletion (LN+T)
Low amount of genome
Subclinical PCV2 infection + Pneumonia
3 Moderate to intense (LN+T)
lymphoid depletion
Moderate amount of genome
PMWS positive
4 Moderate (T) to intense (LN)
lymphoid depletion
Moderate amount of genome
PMWS positive
1LN= Lymph nodes T= tonsil
Vaccination schedule
• Piglet vaccination: 0.5 ml of CIRCOVAC®1
– The first batch was vaccinated in February 08
in the fattening unit
– The subsequent batches were vaccinated 7
days after weaning
1The decision was made to vaccinate piglets in order to see the results faster. As at that time the only vaccine available in Spain against PCV2 was CIRCOVAC, we decided to use this approach following Merial recommendations
Impact of vaccination on mortality • In 2007 an abrupt increase of mortality was observed
• Circovac not only neutralized it but led to lower levels of
mortality than previously observed.
New genetic line
CIRCOVAC
Impact of vaccination: ADWG • While initially the genetic change led to an impairement
of the ADWG, CIRCOVAC subsequently allowed the
manifestation of their genetic potential
Evolution of the average daily gain (g/d)
450
500
550
600
650
700
750
1 3 5 7 9 11 13 15 17 19 21 23 25
Batch
AD
G (
g/d
)
ADG
CIRCOVAC
Impact of vaccination: treatments
• The recovery of the sanitary balance had a
significant impact on the medication
expenses
Evolution of the medication expenses (€/pig)
0
2
4
6
8
10
12
1 3 5 7 9 11 13 15 17 19 21 23 25
Batch
€/
pig
Cost of treatment
CIRCOVAC
Impact of vaccination:
production flow
• The negative impact of the genetic change
on the production flow was clearly
neutralized by Circovac
Evolution of the number of pigs sent to slaughter
480
500
520
540
560
580
600
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Batch
Nb
. o
f p
igs
Sold pigs
This batch consisted of 30 animals less
CIRCOVAC
Impact of vaccination: FCR
• The vaccination restored the deteriorated
conversion index allowing the
manifestation of the genetic potential. Evolution of the FCR
1
1,2
1,4
1,6
1,8
2
2,2
2,4
2,6
2,8
3
1 3 5 7 9 11 13 15 17 19 21 23 25
Batch number
FC
R (
Kg
/kg
)
FCR
CIRCOVAC
Financial impact (€ / pig)
Parameter Before CIRCOVAC Difference Estimated
Impact (€)
% losses 5.7 2.2 3.5
(-175 kg)
+0.20
FCR 2.36 2.18 0.18
(+16 kg/pig)
+3.2
ADWG 597 673 76
(+17 days)
+1.61
Medication 5.7 2.6 3.1 +3.1
Estimated ROI: 8.1
1Average cost of integration 12€/pig & 130 days of fattening period
Conclusions
• In 2007 we experienced an outbreak of PMWS
in a farm with a stabilized sanitary situation
• It looks like this fact was the consequence of a
change in the genetic line
• The introduction of CIRCOVAC a few months
after the beginning of the outbreak not only re-
stablished the sanitary balance but led also to
an improvement of the production parameters