CNSCNS regulates itself: its «psychosomatoses» occur after breach of mast cell-guarded barriers under conjoint co-evolved pluri-site microbial «influence» PNE-Immunology matures from «Solutes» to «Conduits, Cauldrons & Pellets» monitored by PNS to explain LOCAL small-arterial «change» by Mast cells Concatenated Conduits: lymphatics, fascial spaces, adventitial nerves and neural vessels, vessel-vessels, micro-conduits, nerves, sinus cavernosus … Carrying: fluid signals, cells, MCs and their cytokine pellets (Kunder 2008) Mast cells (MCs) are "kanban-hubs" at every stage.

CNSCNS regulates itself: its «psychosomatoses» occur after breach of mast cell-guarded barriers under conjoint co-evolved pluri-site microbial «influence» PNE-Immunology matures from «Solutes» to «Conduits, Cauldrons & Pellets» monitored by PNS to explain LOCAL small-arterial «change» by Mast cells Concatenated Conduits: lymphatics, fascial spaces, adventitial nerves and neural vessels, vessel-vessels, micro-conduits, nerves, sinus cavernosus … Carrying: fluid signals, cells, MCs and their cytokine pellets (Kunder 2008) Mast cells (MCs) are "kanban-hubs" at every stage.

«Real»-Biological Proposals for new paths to bipolarity, mixity, fibromyalgia, and migraine. G.Treviranus, Berne (CH)

«Real»-Biological Proposals for new paths to bipolarity, mixity, fibromyalgia, and migraine. G.Treviranus, Berne (CH)

Present CRISIS OF RESEARCH: Glahn DC (2008): pathways, through which .. remote risk-conferring and … influence on brain … are unknown. Maes M (1995, 2012): a bad, chronic … (neuro)inflammation and (neuro) degenerative processes following less well defined triggers. Whalley (2012) polygenetic risk profiling, … model… in vitro, individuals from the extremes .. to identify the cellular process that underlie imaging findings.

Present CRISIS OF RESEARCH: Glahn DC (2008): pathways, through which .. remote risk-conferring and … influence on brain … are unknown. Maes M (1995, 2012): a bad, chronic … (neuro)inflammation and (neuro) degenerative processes following less well defined triggers. Whalley (2012) polygenetic risk profiling, … model… in vitro, individuals from the extremes .. to identify the cellular process that underlie imaging findings.

www.biposuisse.ch

500+ 500+ Mio. Yrs. Mio. Yrs.

oldolda MC from Malaga

1.) PterygoPalatineGanglion: calms BRAIN MAST CELLs (MCs) -

2.) BRAIN MCs: in meninges, thalamus, putamen, habenula are «psychodynamic migrants», damage & heal the BBB and Gray matter & White mattter. 3.) Peripheral MC-borne TNF «XR» pellets leak from final curve of THORACIC DUCT & reach centripetal adventitial vessels of CAROTIDE Art. & VETEBRAL branches causing local BBB damage e.g. from MCs4.) MC-made pellets beforehand trickle from PNS-influenced LYMPHATIC CAULDRONS cause FIBROMYALGIA/other psycho-SOMATIC STRESS DISORDERS5.) BARTONELLA ungueal Cat scratch Disease, Morgellons etc. a Genome-hijacker & -modifier Genome-hijacker & -modifier ?CNV , Chromosome anoma- ?CNV , Chromosome anoma-lies, lies, MASTOCYTE MASTOCYTE mutations mutations ??

1.) PterygoPalatineGanglion: calms BRAIN MAST CELLs (MCs) -

2.) BRAIN MCs: in meninges, thalamus, putamen, habenula are «psychodynamic migrants», damage & heal the BBB and Gray matter & White mattter. 3.) Peripheral MC-borne TNF «XR» pellets leak from final curve of THORACIC DUCT & reach centripetal adventitial vessels of CAROTIDE Art. & VETEBRAL branches causing local BBB damage e.g. from MCs4.) MC-made pellets beforehand trickle from PNS-influenced LYMPHATIC CAULDRONS cause FIBROMYALGIA/other psycho-SOMATIC STRESS DISORDERS5.) BARTONELLA ungueal Cat scratch Disease, Morgellons etc. a Genome-hijacker & -modifier Genome-hijacker & -modifier ?CNV , Chromosome anoma- ?CNV , Chromosome anoma-lies, lies, MASTOCYTE MASTOCYTE mutations mutations ??

Bartonella-caused mutation triple hypothesis: a genetic link to Mastocyte activation syndromes & BPAD?

2012: PPG calms brain MCs? A “NEW TWIST for BPAD?” (Hagop)

2013:“Mastocyte Activation Syndromes” – a PARADIGM DISORDER for BPAD?2014 ? Peru-Brazil migrants mission for Bartonella bac. with additional B.henselae -PCR & HCl-33 for BPAD?? Infect MCs w/ Bartonella ? ? Skin test for BH in Mastocyte Activation Syndromes ? HCl-33 in common depression

Full circle? Full circle? ImmuneR ImmuneR weakweakBART-like germs invade, lymphatics,BART-like germs invade, lymphatics,CNS… CNS… Behavior: «thrive & Behavior: «thrive & don’t fear cats»don’t fear cats»& BONE MARROW & BONE MARROW mutationsmutations MC-activation syndrome & IR MC MC-activation syndrome & IR MC IR-deficiency IR-deficiency more infections.more infections.

SYSTEMIC MAST SYSTEMIC MAST CELL ACTIVATION CELL ACTIVATION SyndromeSyndrome1991 Metcalfe: MILD Systemic MASTOCYTOSIS with NORMAL SKIN2007 Akin: aberrant mast cell population with idiopathic ANAPHYLAXIS2009 Bonadonna: CLONAL mast cell disorders in systemic reactions to BEE-stings and serum TRYPTASE2010 Alvarez-Twose:… with SYSTEMIC MAST CELL ACTIVATION

Various mutations in Mastocyte activation syndrome (with anaphylaxia)

Rogers MP, HMS 1985

What kind of rhinosinusitis?

.

Alice In Wonderland SyndromePEDUNCULAR HALLUCINOSIS

M, 1977: Italian.RC-BPAD1 since childhood, CSA, OH++, sex++

Spectacular hallucinations: devils all around him, micro- / devils all around him, micro- / macropsiamacropsia,TLE-like. Talented.

NOT psychotic , insight.Univ. depart.: F20 & Xeplion

i.m.rTMS: L DFPC: halluc. STOPPED ! He refuses further TMS because”I NEED the “Fire in my legs”

as FEEDBACK from GOD”

P. G

rof

Angioma & Zoonotic psychosis (sheep). Periungueal tendernessPeriungueal tenderness & ascending along lymphatics is «difficult data» …

M, 1936: M, 1936: Generalized,

clinical, serological,

antibiotic- responsive

Bartonella henselae:

Small serie’s clusters are chance, Small serie’s clusters are chance, but 5 independent recent cases but 5 independent recent cases had clinico-serological and/or MRT had clinico-serological and/or MRT signs ++ suggestive of BARTONELLAsigns ++ suggestive of BARTONELLA

Early vertebralis arteriitis SCAR?

MC extracelluar traps? M, 1964: M, 1964:

TY-Kurd Anergic BPAD-2 Cthymia, OH ++

«Mickey’s cheek» lesions of DORSAL MIDBRAIN : 1 Bartonella henselae BHBHPeri red nucleus =O red nucleus =O SCAR or ? ongoing Bartonellosis ? with +potential for angiomas?

Where is Where is your your clinical clinical datadata??

Thoracic duct & Venositis?

pyoderma gangrenosum

BH caused oculo-glandular syn-drome of dorsal midbrain of Parinaud 1898 !

Lhermitte

1. BPAD SYSTEMIC AUTOINFLAMMATION Leboyer 2012

CONFLICT= trigger Grunze 2012 - ? via MAST CELLS (MCs) ? ? 2. Classical dimensions THOUGHT-ACTION-MOOD MAP ONTO Cortico-SubCortical-Circuits Anderson 1986 which are BUNDLED at the THALAMUS GT. IRBD 2012 ? in order to receive MC-signals? 3. NASAL Ganglion [PPG] ? exerts TONIC A.Ch-anti-inflammatory PARASYMPATHETIC BRAKE ON MC otherwhise opening BBB? IRBD 2012

4. TRIGEMINAL afferents or STOP of biting (TG mot)? inhibit NASAL PPG-brake ? MCs open BBB ACUTE SHAME: STOPS ostracism.

5. HABENULAR MCs brake VTA/SEARCH-system CHRONIC SHAME: STOPS rivalry. GT. IRBD 2013 Can ISTDP (H.Davanloo) REVERTCan ISTDP (H.Davanloo) REVERT SHAME SHAME TO TO GUILT GUILT ??

6. MRI: LEFT hemisphere-LITHIUM-rescue: does it STOP -LITHIUM-rescue: does it STOP MCs ? 7. THREAT signals of co-evolved microbes act via LYMPH-conduits through MC-pellets on ? own vessels of Carotide etc. MCs open BBB along SMALL ARTERIES 8. MRI reveils “environmental” GM-losses : HIPPOCAMPUS xxxHIPPOCAMPUS xxxMCs ? RIGHT: non-shared (mostly) environmental damage

1. BPAD SYSTEMIC AUTOINFLAMMATION Leboyer 2012

CONFLICT= trigger Grunze 2012 - ? via MAST CELLS (MCs) ? ? 2. Classical dimensions THOUGHT-ACTION-MOOD MAP ONTO Cortico-SubCortical-Circuits Anderson 1986 which are BUNDLED at the THALAMUS GT. IRBD 2012 ? in order to receive MC-signals? 3. NASAL Ganglion [PPG] ? exerts TONIC A.Ch-anti-inflammatory PARASYMPATHETIC BRAKE ON MC otherwhise opening BBB? IRBD 2012

4. TRIGEMINAL afferents or STOP of biting (TG mot)? inhibit NASAL PPG-brake ? MCs open BBB ACUTE SHAME: STOPS ostracism.

5. HABENULAR MCs brake VTA/SEARCH-system CHRONIC SHAME: STOPS rivalry. GT. IRBD 2013 Can ISTDP (H.Davanloo) REVERTCan ISTDP (H.Davanloo) REVERT SHAME SHAME TO TO GUILT GUILT ??

6. MRI: LEFT hemisphere-LITHIUM-rescue: does it STOP -LITHIUM-rescue: does it STOP MCs ? 7. THREAT signals of co-evolved microbes act via LYMPH-conduits through MC-pellets on ? own vessels of Carotide etc. MCs open BBB along SMALL ARTERIES 8. MRI reveils “environmental” GM-losses : HIPPOCAMPUS xxxHIPPOCAMPUS xxxMCs ? RIGHT: non-shared (mostly) environmental damage

R Li ÷÷ no LEFT

Lenticulostriate SMALL ARTERYNON-sharedNON-shared environment environment Van den Schot, 2010 NON-sharedNON-shared environment environment Van den Schot, 2010

MIDBRAIN ?MIDBRAIN ? MIDBRAIN ?MIDBRAIN ?

HC 2008

HIPPOCAMPUS Szabo 2009

BundledGM x BPAD in TWINSGM x BPAD in TWINS

R R R

T A M

Bearden: CX 2007 GM loss & rescue

LITHIUMLITHIUM acts as MC-

Inhibitor ?

APPROACH CYCLES

PPG-brakeof BBB-MCsMCsbraked by ? TG-baskets

Severity MIG±AURA

MIGTENSCFS HealthyControls

FrequentFrequentMIGMIGRAINEURSRAINEURS

PUTAMEN PUTAMEN

Maleki 2011

PPPPGG

minor part opens to liquid ? from CAROTIS

& Sinus & Sinus Cavernosus Ggl.Cavernosus Ggl.

GM GM May May 20092009

C1)i. Parasympathetic PPG = 2 x 70T cells, of which 5.6T to brain ARTERIES: ? APPROACH network: its VTA has 2 x 400T cells

MIGRAINE: ii.Cortex is hyper-responsive because of low Thalamo-Cortical drive – bc. of MCs? ii. ET1 or kynurenin

CSD-oligemia via ? Pericytes Chauvel 2012 iii.CGRP-receptors only on MCs (but NO axon reflex!) iv. CAUSE of MIG.= Unknown trouble of TG! brainstem!

C1)i. Parasympathetic PPG = 2 x 70T cells, of which 5.6T to brain ARTERIES: ? APPROACH network: its VTA has 2 x 400T cells

MIGRAINE: ii.Cortex is hyper-responsive because of low Thalamo-Cortical drive – bc. of MCs? ii. ET1 or kynurenin

CSD-oligemia via ? Pericytes Chauvel 2012 iii.CGRP-receptors only on MCs (but NO axon reflex!) iv. CAUSE of MIG.= Unknown trouble of TG! brainstem!

ALL HEADACHES show LOCAL GM-loss & WM-loss corr. general COGNITIVE ALL HEADACHES show LOCAL GM-loss & WM-loss corr. general COGNITIVE

OUTPUT= 2 x 2.8T cells BRAIN ARTERIES BRAIN ARTERIES ((? MCs) MCs)

’’Dreier 2002,

CLUST

Subj. severe TENSION

COGNITION/ Memory

HeadachesRavindran 2011

Cell migration can overcome interstitial flow ~.1-4 µm/s

Cell migration can overcome interstitial flow ~.1-4 µm/s

COLLECTING vessel

BARRIERS BARRIERS

PATHOGENSPHYSICAL needs &threats

PATHOGENSPHYSICAL needs &threats

Post-nodalPost-nodal Collectors Collectors lungr & LEFT Thoracicducts

Margaris 2012

Initial LV Initial LV 00..003 mm3 mm

NALT, BALT, GALT, GERALT

TTHHRREEAATT signal

Rat t

ail H

aged

oorn

200

4

L~ NODEL~ NODE

Rat t

ail S

uam

i 201

1

Could pellets cross the barrier of lymphatic collectors or ducts? NO?NO?YESYES, IFIF neurogenic nerves & MCs OPEN LYMPHATICS to hasten the SIGNAL DELIVERIES to LYMPH-NODES required for immune response - at the expense of FLUID DRAINAGE – WHILE microbes are present.

Could pellets cross the barrier of lymphatic collectors or ducts? NO?NO?YESYES, IFIF neurogenic nerves & MCs OPEN LYMPHATICS to hasten the SIGNAL DELIVERIES to LYMPH-NODES required for immune response - at the expense of FLUID DRAINAGE – WHILE microbes are present.

TNF-a fosters : -lymphatic growth-leukocyte & MC transmigration- MC attraction in lung: Baluk 2009

TNF-a fosters : -lymphatic growth-leukocyte & MC transmigration- MC attraction in lung: Baluk 2009

Conduits for lymph-borne signals to the BRAINSTEM? LEFT – more than right - Thoracic DUCT drains a «cauldron»

FROM LYMPHATIC «catchment areas»: face, skin, GIT/UGT, FROM LYMPHATIC «catchment areas»: face, skin, GIT/UGT, CNSCNS

Conduits for lymph-borne signals to the BRAINSTEM? LEFT – more than right - Thoracic DUCT drains a «cauldron»

FROM LYMPHATIC «catchment areas»: face, skin, GIT/UGT, FROM LYMPHATIC «catchment areas»: face, skin, GIT/UGT, CNSCNS

VAVA

Seeger 2009Thoracic ductThoracic duct

SubclaviaSubclaviaSubclaviaSubclavia

Thoracic Thoracic ductduct

through cephalad curves the thoracic DUCTS come to lie within the carotide sheath close to the CAROTIDE and VERTEBRAL art. CAROTIDE and VERTEBRAL art. and to the VAGAL N.VAGAL N.: here TNFa-pellets could cross from the LYMPHATICS to the former’s micro-arteries

through cephalad curves the thoracic DUCTS come to lie within the carotide sheath close to the CAROTIDE and VERTEBRAL art. CAROTIDE and VERTEBRAL art. and to the VAGAL N.VAGAL N.: here TNFa-pellets could cross from the LYMPHATICS to the former’s micro-arteries

VAGAL N.VAGAL N.

Seeger 2009

Inflammatory VEIN Inflammatory VEIN stenosesstenoses of of IJV IJV in in MSclerosisMSclerosis?? 91% or of or of Azygos Azygos 86% (Zamboni 2009) with Type III collagen; but no myofibroblast (Coen 2013).Lymphatic & Lymphatic & MC-mediated? MC-mediated? VARICOSE VEINS driven by C-fibres & mast cells (Vital 2010) ;C5a activation (deVries 2013).

Inflammatory VEIN Inflammatory VEIN stenosesstenoses of of IJV IJV in in MSclerosisMSclerosis?? 91% or of or of Azygos Azygos 86% (Zamboni 2009) with Type III collagen; but no myofibroblast (Coen 2013).Lymphatic & Lymphatic & MC-mediated? MC-mediated? VARICOSE VEINS driven by C-fibres & mast cells (Vital 2010) ;C5a activation (deVries 2013).

R Thorac duct

thoracic duct pellet-leaks maybe reach the brachial the brachial plexus perineural plexus perineural veins veins behind the ant. scalene, then the radicular veins and Bateson’s Bateson’s plexus.

thoracic duct pellet-leaks maybe reach the brachial the brachial plexus perineural plexus perineural veins veins behind the ant. scalene, then the radicular veins and Bateson’s Bateson’s plexus.

Pellet TNF acts on the vasa vasorum of the CAROTIDE branches CAROTIDE branches and causes ? MC-modifying «arteriitis» of BBB..

The VERTEBRAL ARTERIES VERTEBRAL ARTERIES fuse to the Basilar Art. Basilar Art. preserving LATERALITY of ist walls. The left VA left VA is crossed by the Thoracic Duct, which lies inside the carotid sheath with the IJV and the vagal nerve which are also inflamed via the proper micro-arteries.The transversa colli Art. transversa colli Art. could inflame the brachial plexus.

Pellet TNF acts on the vasa vasorum of the CAROTIDE branches CAROTIDE branches and causes ? MC-modifying «arteriitis» of BBB..

The VERTEBRAL ARTERIES VERTEBRAL ARTERIES fuse to the Basilar Art. Basilar Art. preserving LATERALITY of ist walls. The left VA left VA is crossed by the Thoracic Duct, which lies inside the carotid sheath with the IJV and the vagal nerve which are also inflamed via the proper micro-arteries.The transversa colli Art. transversa colli Art. could inflame the brachial plexus.

MC-mediatedMC-mediated ? inflammatory inflammatory VASA VASA VASORUM VASORUM dissectionsdissections

MC-mediatedMC-mediated ? inflammatory inflammatory VASA VASA VASORUM VASORUM dissectionsdissections

MC-MC-mediated mediated ? Reversible cerebral vaso-constriction syndrome

MC-MC-mediated mediated ? Reversible cerebral vaso-constriction syndrome

MC-mediatedMC-mediated? Rupture Rupture of atherosclerotic plaqueof atherosclerotic plaque

Willems 2013Willems 2013

MC-mediatedMC-mediated? Rupture Rupture of atherosclerotic plaqueof atherosclerotic plaque

Willems 2013Willems 2013

KLC2 lowers AMPA: TAT-KLCpCDK inhibitsinhibits GSK3-P~ylation of KLC2 needed for (rat) AMPAR-trafficking and «mood-stabilizing» in the rat (Du, Manji 2009). But KLC2 is ALSO needed to fetch the pump Na+/K+-ATPaseNa+/K+-ATPase when MCs fill with Na+ after any release (± IgE).

micro biomechanicsnano biomechanics

Trzewik 2001

LYMPHATICLYMPHATICmicrovalvesmicrovalves

LYMPHATIC «open end»

Bonghan «primo-ves-sels» slide freely on

brain surfaces & within vessels

«The pump» Na+/K+-ATPase neuro-ISO-FORM 3 is candidate for mood swings El-Mailakh 1983.Only BPAD patients already stabilized on LI: the pump and oxidative stress Bannerjee 2012

Ouabaïne-like cardenolides from adrenals e.g. INHIBIT the pump causing TNF-related (TRAIL) apoptosis Panayiotidis 2010

brain-slice «irritability», stress-hypertension and damages healed by LITHIUM (not VPA) Hennion, El-Mailakh 2002

Icv.-Ouabaïne-Mania-rats release more DA in mPFC – LI no use!Sui (Shanghai) 2013

AMPH the pump in rats – unless on LI or VPAMAMPH and pro-inflammatory CKs pump isoform3 bc. of downstream Erk Pendyala 2012

«pump» ISOFORM 3 is related to MIGRAINE

Bonghan Rabbit ventricle

Good or bad guy ?

Trzewik 2001

Particle inside!

ABC-C1 ABC-C1 trans-trans-porter = multi-porter = multi-drug-resistance drug-resistance MDR1MDR1: : carries S1Pcarries S1P – – Fingolimod – Fingolimod – targeted targeted prime prime modulator of modulator of MC functions.MC functions.

BARTONELLABARTONELLA

Mphage

media EC

prolif via

HIF-1,

VEGF..

Scheidegger 2011

F10 F10 & BP& BP

OH intake in amygdalar k.o.-14-3-3ζ which is needed by KLC2 …

MC & BBB: MC are longlived (wks-mo), but migrate within hour from blood to brain:

TNF- essential 1st contact with EC (Kneilling 2009)

MC & BBB: MC are longlived (wks-mo), but migrate within hour from blood to brain:

TNF- essential 1st contact with EC (Kneilling 2009)

MCs steer Leukocyte

& own entry ± entry ±

similarly similarly

MCs steer Leukocyte

& own entry ± entry ±

similarly similarly

MCs BasophilsBasophils

BBB

Paul Ehrlich

1854-1915

LeukLeuk

LeukLeuk

LeukLeuk

R. Post

RR-MSMS: Flares: days, Remission: weeks; 70%70% progressiveprogressive

BPAD

ECEC

TTNNFF

Theoharides N.Y. MCs in ASDMCs in MSetc.

Theoharides N.Y. MCs in ASDMCs in MSetc.

ONGOING CAUSE ONGOING CAUSE OLD or NEW SYMPTOMS OLD or NEW SYMPTOMS

TREAT ONGOING CAUSE TREAT ONGOING CAUSE RECOVERY RECOVERY

Rudich et 2012

B.2) BRAIN MCs: open, damage & seal BBB: are hubshubs

B.2) BRAIN MCs: open, damage & seal BBB: are hubshubs

MCs are long-living hubs w/ convergent divergent signals on ~100 / ~40 receptorsresonating with Stress-axes HPA, HThyrA,Ntroph/peptA

MCs are long-living hubs w/ convergent divergent signals on ~100 / ~40 receptorsresonating with Stress-axes HPA, HThyrA,Ntroph/peptA

SelyeSelye

Addictive signals calm (CB, Nicotine, BZD) or release + H (OH, Op.) or via MKLC (OH) AMPH ??

Addictive signals calm (CB, Nicotine, BZD) or release + H (OH, Op.) or via MKLC (OH) AMPH ??

Schizophr Bull. 1995;21(2):167-71.

BIPOLAR & Rheumatism “Gelenkrheumatismus”: E. KraepelinSCHIZOPHRENIA & RA: Fuller Torrey & Yolken++ >HCO cats in childhood Similarities:class II HLA Ag. ? infectious etiology: retroviruses, HERPES viruses (EBV, HSV) Toxoplasma gondii Inverse correlation “once a person gets one (..) relatively immune to the other.” Torrey EF, Yolken RH, 2001

BIPOLAR & Rheumatism “Gelenkrheumatismus”: E. KraepelinSCHIZOPHRENIA & RA: Fuller Torrey & Yolken++ >HCO cats in childhood Similarities:class II HLA Ag. ? infectious etiology: retroviruses, HERPES viruses (EBV, HSV) Toxoplasma gondii Inverse correlation “once a person gets one (..) relatively immune to the other.” Torrey EF, Yolken RH, 2001

Bartonella H-like bacteria CAUSE «epigenetic» hijacking of the histone acetylase and repair systems & genetic changes to the human genome incl. CNV

Bartonella H-like bacteria CAUSE «epigenetic» hijacking of the histone acetylase and repair systems & genetic changes to the human genome incl. CNV

FM: sensitivity (detection ok) in noxious & multiple sensory modes: sounds; even pleasant odors, which parallels tenderness – and ? Irritability ?

FM: sensitivity (detection ok) in noxious & multiple sensory modes: sounds; even pleasant odors, which parallels tenderness – and ? Irritability ?

Ceko et al.(McGill) 2012 «4 possible factors»: 1) ongoing peripheral source of input from C nociceptors other than applied S ; 2) sensitized NMDA-R (Staud: Can be dampened in HCO too: post-NMDA-R .. 3) (..) descending modulation of DH DNIC MOR, 2ADR etc. pp.!; 4) supraspinal level.

Ceko et al.(McGill) 2012 «4 possible factors»: 1) ongoing peripheral source of input from C nociceptors other than applied S ; 2) sensitized NMDA-R (Staud: Can be dampened in HCO too: post-NMDA-R .. 3) (..) descending modulation of DH DNIC MOR, 2ADR etc. pp.!; 4) supraspinal level.

MCs unleashed by PPG … LI case reports; VALP: none.LIMBIC DA Striatal D2/D3+:pain; COMTval/val (DA -):pain .- FM: DRD3-SNP.

MCs unleashed by PPG … LI case reports; VALP: none.LIMBIC DA Striatal D2/D3+:pain; COMTval/val (DA -):pain .- FM: DRD3-SNP.

? ANTICIPATION Thalamic MCs?Thalamic MCs?

F20F20

Ceko, Bushnell, Gracely (2012) Tran, Casey 2010Potvin 2008, 2009Lévesque 2012r= - 0.70 PANNS+

Ceko, Bushnell, Gracely (2012) Tran, Casey 2010Potvin 2008, 2009Lévesque 2012r= - 0.70 PANNS+

55, , 1010, , 20 s & 20 s 20 s & 20 s HEAT HEAT perception intensityperception intensity

Qrost-v. BRAIN gyrus rectus {SHAME – GUILT}Qpost.-d. BRAINQThalamusCR QThalamus

Qrost-v. BRAIN gyrus rectus {SHAME – GUILT}Qpost.-d. BRAINQThalamusCR QThalamus

TNF-

MC

MCMC

www.bipoSuisse.ch

Research Gatewww.Prezi.com

Muchas gracias!

PC EC AC