STUDY OF SERUM ZINC AND STUDY OF SERUM ZINC AND COPPER IN NEONATES AND COPPER IN NEONATES AND

THEIR MOTHERSTHEIR MOTHERS

Soumya Ranjan ParidaBasic B.Sc. Nursing 4th year

Sum Nursing College

ZINCZINC• Third most abundant trace element after

iron and fluorine.• Most abundant intracellular metal after

potassium and calcium.• Prosthetic group in metalloenzymes like

carbonic enhydrase and superoxide dismutase.

• Important for body growth & development of CNS & its myelination and bone mineralisation of fetus.

• Synthesis of DNA & RNA.• Helps in tissue repair and phagocytosis.

COPPERCOPPER• Essential part of cuproproteins.• Regulation of biological amines in

brain.• Prosthetic group in tyrosinase and

superoxide dismutase.

AIMS AND OBJECTIVESAIMS AND OBJECTIVES• 1.To find out level of zinc & copper in pregnant

women & their newborns at the time of delivery.

• 2.To find out relation between maternal serum zinc & copper status and serum zinc,copper status of their newborns.

• 3.To find out the correlation of these values with birth weight and gestational age.

• 4.To find out whether deficiency of these trace metals is associated with IUGR & prematurity.

Material and MethodsMaterial and Methods• The study group comprised 100 newborns

delivered in maternity ward of P.B.M. hospital,Bikaner and their mothers and 20 nonpregnant women to act as control.

• Excluding,neonates with perinatal complication affecting the physical & neurological status & newborns with evident congenital malformations.

• Method-atomic absorption spectrophotometry

OBSERVATIONS

MEAN SERUM MEAN SERUM ZINCZINC AND AND COPPERCOPPER LEVELS IN MATERNAL AND CORD LEVELS IN MATERNAL AND CORD

BLOODBLOOD

020406080

100120140160180

SE

RU

MZ

INC

LE

VE

L

SE

RU

MC

OP

PE

RL

EV

EL

MATERNAL ZINCLEVEL

CORD SERUMZINC LEVEL

MATERNALCOPPER LEVEL

CORD SERUMCOPPER LEVEL

MEAN CORD SERUM MEAN CORD SERUM ZINCZINC AND AND COPPERCOPPER OF TERM AND PRETERM NEWBORNOF TERM AND PRETERM NEWBORN

0

20

40

60

80

100

120

SE

RU

MZ

INC

LE

VE

L

SE

RU

MC

OP

PE

RL

EV

EL

TERM SERUMZINC LEVEL

PRETERM SERUMZINC LEVEL

TERM SERUMCOPPER LEVEL

PRETERM SERUMCOPPER LEVEL

MEAN SERUM MEAN SERUM ZINCZINC AND AND COPPER COPPER LEVELS LEVELS OF OF TERMTERM NEWBORNS AND THEIR MOTHERS NEWBORNS AND THEIR MOTHERS

020

406080

100120

140160

SE

RU

MZ

INC

LE

VE

L

SE

RU

MC

OP

PE

RL

EV

EL

MATERNALSERUM ZINCLEVEL

TERMNEWBORNSERUM ZINCLEVEL

MATERNALSERUM COPPERLEVEL

TERMNEWBORNSERUM COPPERLEVEL

RELATION OF CORD SERUM RELATION OF CORD SERUM ZINCZINC AND AND GESTATIONAL AGEGESTATIONAL AGE

0

20

40

60

80

100

120

34 WKS -40 WKS

CO

RD

SE

RU

M Z

INC

LE

VE

L

mic

rog

ram

s/d

l

cord serumzinc level

RELATION OF CORD SERUM RELATION OF CORD SERUM ZINCZINC AND AND BIRTH WEIGHTBIRTH WEIGHT

0

20

40

60

80

100

120

140

BIRTH WEIGHT(kg)

CO

RD

SE

RU

M Z

INC

m

icro

gra

ms/

dl

SERUM ZINCLEVEL

RELATION OF CORD SERUM RELATION OF CORD SERUM COPPER AND GESTATIONAL AGECOPPER AND GESTATIONAL AGE

05

10152025303540

30 33 36 39 42

GESTATIONAL AGE(WEEKS)

CO

RD

SER

UM

CO

PP

ER

LEV

EL(m

icro

gra

m/

dl)

RELATION OF CORD SERUM COPPER RELATION OF CORD SERUM COPPER AND BIRTH WEIGHTAND BIRTH WEIGHT

0

10

20

30

40

50

60

1 1.5 2 2.5 3 3.5 4

BIRTH WEIGHT(KG)

CO

RD

SER

UM

C

OP

PER

(mic

rog

ram

/d

l)

MEAN CORD SERUM ZINC LEVEL IN MEAN CORD SERUM ZINC LEVEL IN RELATION TO INTRAUTERINE GROWTH RELATION TO INTRAUTERINE GROWTH

STATUS AT TERM AND PRETERMSTATUS AT TERM AND PRETERM

0

20

40

60

80

100

120

CO

RD

SER

UM

ZIN

C

LEV

EL(m

icro

gra

m/dl)

TERM AGATERM SGATERM LGAPRETERM AGAPRETERM SGA

MEAN CORD SERUM COPPERMEAN CORD SERUM COPPER LEVEL IN RELATION TO LEVEL IN RELATION TO INTRAUTERINE GROWTH STATUS AT TERM AND INTRAUTERINE GROWTH STATUS AT TERM AND

PRETERMPRETERM

0

5

10

15

20

25

30

35

40

45

50

CO

RD

SER

UM

CO

PP

ER

LEV

EL(m

icro

gra

ms/d

l)

TERM AGATERM SGATERM LGAPRETERM AGAPRETERM SGA

CONCLUSIONCONCLUSION• 1.Cord serum zinc level is higher than

maternal serum & copper level is lower.• 2.Prematurity is associated with lower

cord levels of serum zinc & copper levels.• 3.Our study has revealed that fetal

hypozincemia was associated with IUGR in our preterm group emphasising the importance of zinc in intrauterine growth of fetus.

• 4.Several trials have suggested reduction in preterm & LBW on zinc supplementation in mother.

THANKS