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Page 1: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Zdeněk Fík

Page 2: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auris media Auris interna

Auris externa

myrinx

Foramen

rotundum

A Meatus acusticus externus

B Membrana tympani

C Cavum tympani

D Cochlea

E Canalis semicircularis ant.

F Tuba auditiva

Page 3: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Pinna

Elastic cartilage – missing in lobulus

Page 4: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Perichondritis

-piercing

compliaction

Cauliflower deformity

– wrestling fighter

Page 5: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 6: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Otapostasis

Page 7: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auricular acupuncture

Page 8: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Frank sign

Griffing G. N Engl J Med 2014;370:e15.

Sign of early degeneration

of elastic fibres in the skin

and vessels.

Indicates possible

damage of coronary

arteries.

Page 9: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 10: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Nanda, A., et al. (2011). "Implant-supported

auricular prosthesis." Indian J Dent Res

22(1): 152-156.

Page 11: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ear canal

Page 12: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Meatus acusticus externus

Page 13: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

CT horizontal section

meatus acusticus int

meatusacusticus

externus

cochlea

celullae mastoideae

cavum tympani caput mandibulae

Page 14: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 15: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ear canal atresia

atresia

Page 16: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tragi – hair in the ear canal (adults)

• Radchakanta Bažpaj and his 13 cm long tragi – Guinness world record

Page 17: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ear canal irrigation

Page 18: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Earwax removal

Glandulae ceruminosae

Page 19: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Wide and straight ear canal

Page 20: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Eardrum

Page 21: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

1 - stria mallearis

2 – plica mallearis ant

3 – plica mallearis post

4 – pars flaccida

membranae tympani

5 – umbo

6 - prominentia mallearis

43

6

5

7 – pars tensa

membranae

tympani

8 - reflex

7

8

1

2

Eardrum - adult

Eardrum - child

Otoscopic view

Page 22: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 23: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Normal otoscopic view

Page 24: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Pathologic otoscopy view

Page 25: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paracentesis

RE

nape

neckHair?

Page 26: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Myringostomy – ventilation tube

• Secretory otitis media

Page 27: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Pars flaccida

Pars tensa

Page 28: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tympanic paraganglioma

Page 29: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Middle ear

Page 30: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tympanic cavity

malleus incus stapes

fenestra

rotundamembrana

tympanituba

Eustachi

paries membranaceus

paries labyrinticus

paries tegmentalis

paries jugularis

paries caroticus

paries mastoideus

Page 31: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tympanic cavity

M I

S

Canalis semicircularis

lateralis

N. facialis

Promontory – 1. turn

of the cochlea

Fenestra ovalis -

vestbuli

Fenestra rotunda -

cochleae

Membrana

tympani

Recessus

epitympanicus

Bulbus v. jugularis int.

Fossa cranii media

L M

Page 32: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries membranaceus• Lateral wall

epitympanum

Page 33: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries labyrinthicus

• Medial wall

Fenestra vestibuli ovalis

Fenestra cochlae rotundum

Prominentia canalis semicircularis lat

Prominentia canalis n.facialis

Page 34: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries caroticus

• Anterior wall

Tuba auditiva

Page 35: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries mastoideus

• Posterior wall

Antrum mastoideum

Eminentia pyramidalis

Chorda tympani

Page 36: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries tegmentalis• Upper wall

Page 37: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Paries jugularis• Lower wall

Page 38: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ossicula auditus

Page 39: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Malleus, incus, stapes

Page 40: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ossicula auditus

Page 41: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tensor tympani muscle

(n.V)

Stapedial muscle

(n.VII)

Page 42: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tympanic cavity – proportions

Page 43: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cavum tympani – blood supply

arterie tympanicae (superior, inferior, anterior, posterior) –

AT (S,I,A,P)

ATP (a. auricularis post.

– a. stylomastoidea)

+ chorda tympani

P A

ATI (a pharyngea

ascendens) +

n.tympanicus

N. VII

ATA

(a.maxillaris)

Rami

caroticotympanici

ATS (a.meningea

media) +

n.petrosus minor

Page 44: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Blood and nervous supply

ATP + n.VII

ATA (fissura petrotympanica)

+ chorda tympani

ATI + n. tympanicus

ATS +n.petrosus minor

Page 45: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Plexus

pterygoideus

V. meningea media

+ sinus petrosus sup.

Venous drainage

Page 46: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

CT otitis and mastoiditis

Page 47: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cholesteatoma – right side

Page 48: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Eustachian tube 1/3 bone 2/3 cartilage

1. 3cm short

2. 2,5mm wide

3. open

4. straight

1. 3,8cm long

2. 1 mm narrow

3. partly open

4. bent

AdultChildren

Page 49: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tuba Eustachi

Page 50: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Middle ear ventilation during swallowing

Cartilago tubae auditivae

lamina medialis et lateralis

M. tensor veli palatini

M. levator veli palatini

Page 51: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auris internalabyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

Page 52: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Labyrinthus osseus

Separated with spongiosa

from os petrosum

Exceptions:

• Fundus meatus acustici interni

• Facies ventrobasalis ossis petrosis

Page 53: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Position of the inner ear

cochlea

canales

semicirculares

(ant., post., lat.)

n.vestibulocochlearis

Page 54: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Canales semicirculares

Vestibulum

Cochlea

Labyrinthus osseus

Auris interna

labyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

Page 55: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cochlea

Lamina spiralis ossea

canalis spiralis osseus

• Modiolus

• Canalis longitudinalis modioli

Scala vestibuli

Scala tympani

Auris interna

labyrinthus osseus

cochlea

vestibulum

canales

semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

Page 56: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

VestibulumAuris interna

labyrinthus osseus

cochlea

vestibulum

canales

semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus

semicirculares

ductus cochlearis

Maculae cribrosae

Recessus ellipticus (utricularis)

Recessus sphericus

(saccularis)

Page 57: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Canales cemicirculares

Auris interna

labyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

L

A

P

Crus simplex

Crus ampullare

Crus commune

Page 58: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Labyrinthus membranaceus

Auris interna

labyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

Utriculus

Sacculus

Ductus reuinensDuctus endolymphaticus

Saccus endolymphaticus

Page 59: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auris interna

labyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

Semicircular canal

Utriculus,sacculus

Irritation at the beginning and the end of movement

Irritation during movement

Page 60: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ductus cochlearisAuris interna

labyrinthus osseus

cochlea

vestibulum

canales semicirculares

labyrinthus membranaceus

utriculus

sacculus

ductus semicirculares

ductus cochlearis

ScV

ScT

ScM

ScV, ScT – perilymph

ScM – endolymphCorti cells.

Tunnel of Corti

Outer hair cells

Inner hair cells

Page 61: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cochlear section

1-ductus cochlearis

2- scala vestibuli

3 -scala tympani

4 –membrana vestibularis

(Reissneri)

5- membrana basilaris

6- membrana tectoria

7 – stria vascularis

8- ganglion spirale cochleae

9 – lamina spiralis ossea

Page 62: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Inner hair cell

Afferent axon

Efferent axon

Contact with bipolar cells

Outer hair cell

Efferent axon

Afferent axon

Contact with unipolar cells

3 500

1 row

15 000

3-4 rows

Page 63: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Electron microscopy

Inner

Outer

Page 64: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Mechanoelectric

transduction

Tip links

Page 65: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Hair cells mediators

Afferent Efferent

Page 66: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Organ of Corti damage

Oter hair cells onlyOuter hair cells only

All hair cells All hair cells and ganglion

cohleare

Page 67: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cochlea

perilmyph movement

1-ductus cochlearis

2 – scala vestibuli

3 – scala tympani

4 – ganglion spirale cochleae

5 – nervus cochlearis

helicotrema

fenestra vestibuli

fenestra cochleae

Page 68: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Inner ear

Dura mater

utriculus

sacculus

canalis

semicircularisendolymphatic

ductductus

cochlearis

ductus reuniens

vestibulum

cochlea

saccus

endolymphaticus

scala

vestibuli scala

tympanicanaliculus

cochlearis

ampulla

perilymph

endolymph

Page 69: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Meatus acusticus

internus

Page 70: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

meatus acusticus internus

(n.VII. a n.VIII.)

fossa subarcuata

apertura externa

aquaeductus vestibuli

foramen jugulare

(n.IX., X., a XI.)

canalis nervi hypoglossi

sulcus sinus petrosi

inferioris

sulcus sinus sigmoidei

Fossa cranii posterior

Posterior surface of the pyramid

Page 71: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Endolymph:

production - stria vascularis

Resorption – saccus endolymphaticus

Page 72: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Zdeněk Fík

Veronika Němcová

Page 73: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Embryology

Page 74: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

External + middle ear

Pharyngeal arch

Pharyngeal cleft Pharyngeal pouch

1. + 2.

Sadler TW, Langman’s Medical Embryology 10th Edition,

Lippincott Williams and Wilkins, Baltimore MD, 2006

Otic placode

Page 75: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Meckel‘s cartilage

Reichert‘s cartilage

malleus

incus

Maxilla

Mandibula

Temporal b.

Stapes

Processus styloideus

External + middle ear

Sadler TW, Langman’s Medical Embryology 10th Edition,

Lippincott Williams and Wilkins, Baltimore MD, 2006

Page 76: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Ear development

frontal sections

• Pinna–hillocks of 1. and 2.

branchial arch

• External ear canal

ectoderm of the 1.

branchial pit

• Drum– 3 layers ectoderm,

mesenchym, entoderm

• Cavum tympani, and tuba

Eustachi – from the 1.

pharyngeal pouch -

recessus tubotympanicus,

entodermal epithelium

• Ossicles– from the

mesenchym of the 1.

(malleus, incus) a 2.

(stapes) branchial arch

(cartilago Meckeli et

Reicherti)

• Inner ear –from the otic

placode (ektodermal plate),

which deepens and

pinches off from the

surface and forms the otic

vesicle (otocyst). The

membranous labyrinth is

developed from the otocyst

with ectodermal epithelium

inside

Page 77: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Outer and middle ear

Ectoderm

Tubotympanic recess

Entoderm

Mesenchym

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6.week 9.week

5.week

Pinna development

Page 79: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Inner ear

Otic

placode

Otic cupOtic

capsule

Co+Vest

ganglion

24.day 27.day 5.week

Page 80: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

• The otic pit forms as this thickened (placodal)

ectoderm invaginates

Day 26

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• The otic pit deepens and pinches off from the surface.

Day 28

Page 82: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

.

• A cut through the otic pit at the time it

is completing its separation from the

surface ectoderm illustrates

Day 29

Page 83: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

The stato (vestibulo)-acoustic ganglion begins to

form between the otic vesicle (otocyst) and the

neural tube.

Day 30

Page 84: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Day 36

Development of the membranous labyrinth

Page 85: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Oval

window

Round

window

Cochlear duct of human fetus - 5 month of gestation

Page 86: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Developmental defects

Page 87: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auditory pathway

Page 88: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Inner hair cell

Afferent axon

Efferent axon

Contact with bipolar cells

Outer hair cell

Efferent axon

Afferent axon

Contact with unipolar cells

3 500

1 row

15 000

3-4 rows

Page 89: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

1- nuclei cochleares

2-ncl. olivaris sup.lat

3-ncl olivaris sup medialis

4-spodina IV. komory

1- nuclei cochleares

2-ncl. olivaris sup.lat

3-ncl olivaris sup medialis

4-spodina IV. komory

Afferents and efferents of the hair cells

Page 90: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Auditory pathway

• 4-neuronová•4-neuron

•Receptor – sensory cell!!

Page 91: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tonotopic organisation

Membrana basilaris – apex – deep tones, basis high

Nuclei cochleares – deep tones ventrally

Colliculus inferior – deep tones dorsally

Corpus geniculatum mediale – deep tones laterally

Sluchová kůra – deep tones anteriorly

Page 92: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 93: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

VIII.nerve

Trapezoid body

Lateral lemniscus

Radiatio

acustica

(auditory

radiations) ICCGM

BA 41,42

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Page 95: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 96: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Descendent tracts in the auditory pathway

Page 97: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Tractus vestibulo–

spinalis

cerebellaris

nuclearis

reticularis

Vestibular pathway•3-neuron

•Receptor – sensory cell!!Thalamus – VPL, VPM, VL

1

2

3

M,L,S

M,L,I

Page 98: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Vestibular pathway

• Receptor – hair cell in the macula sacculi

et utriculi, cristae ampullares

• 1.N – bipolar cell in the ggl. vestibuli

• 2.N – vestibular nucleus

• 3.N – ventral nuclei of the thalamus

Cortex: temp. and pariet. lobe

Page 99: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

The utricle and the saccule detect linear

accelaration

Macula

The axis of mechanical sensivity of each hair cell

in the utricle is orientated toward the striola

Page 100: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Function of the horizontal semicircular

canals

Page 101: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Vestibulo-ocular reflex

Page 102: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Vestibulo-nuclear

connections

macula

sacculi et

utriculi

cristae

ampullares

Page 103: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

What with the imparied

hearing??

Page 104: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

• Conductive – affected external or middle ear

• Sensorineural – affected inner ear, cochlear nerve or

auditory tract

• Mixed

Types of hearing loss

Page 105: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

How we hear?

Page 106: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Noise

Page 107: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Presbyacusis

Page 108: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Bone conduction

Page 109: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Hearing aids

Page 110: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Hearing aid

Page 111: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

TORP/PORP

Page 112: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

BAHA

(Bone anchored hearing device)

Page 113: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

BAHA

Page 114: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

BAHA

Page 115: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Bonebridge

Page 116: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Bonebridge

Page 117: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Active middle ear implant

Page 118: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Vibrant soundbidge

Page 119: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cochlear implant

Page 120: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli
Page 121: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Cochlear implant

Page 122: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Elektroacustic stimulation

Page 123: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

X-rays control

Page 124: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Brainstem implant

Page 125: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Surgical approaches

Page 126: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Suggested literature

• Petrovický, Anatomie III

• Černý, Betka, Atlas anatomie ucha

• Kahle, Frotscher, Color Atlas of Human Anatomy

• Gray, Anatomy

• tenDonkelaar et al., Klinische anatomie en embryologie

• http://www.iurc.montp.inserm.fr/cric/audition/english/corti/fcorti.htm

• http://www.rcsullivan.com/www/ears.htm

• http://anatomy.uams.edu/anatomyhtml/neuro_atlas.html

• http://anatomy.uams.edu/anatomyhtml/gross.html

• http://www.ghorayeb.com/Pictures.html

• http://www.med.unc.edu/embryo_images/unit-welcome/welcome_htms/contents.htm

• H. Greess1 · U.Baum1 · W.Römer1 · B.Tomandl2 · W. Bautz1

1 Institut für Diagnostische Radiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg 2Abteilung für Neuroradiologie der Neurochirurgischen Klinik,

Friedrich-Alexander-Universität Erlangen-Nürnberg

CT und MRT des Felsenbeins

http://www.radiologyassistant.nl/en/43facba0911f5http://www.radiologen.nl/ostemporale/pagina's/Coronaal/index.html

• Černý, Betka, Atlas anatomie ucha

• http://www.iurc.montp.inserm.fr/cric/audition/english/corti/fcorti.htm

• http://www.rcsullivan.com/www/ears.htm

• http://anatomy.uams.edu/anatomyhtml/neuro_atlas.html

• http://anatomy.uams.edu/anatomyhtml/gross.html

Page 127: Zdeněk Fík - Univerzita Karlova · Vestibular pathway •Receptor –hair cell in the macula sacculi et utriculi, cristae ampullares •1.N –bipolar cell in the ggl. vestibuli

Thank you for attention