MapID MapName Number_of_SigGenes01100 Metabolic pathways 16004110 Cell cycle 4705200 Pathways in cancer 6904115 p53 signaling pathway 3205034 Alcoholism 4105203 Viral carcinogenesis 4103030 DNA replication 2400230 Purine metabolism 3805166 HTLV-I infection 4404151 PI3K-Akt signaling pathway 4803460 Fanconi anemia pathway 2405222 Small cell lung cancer 2704512 ECM-receptor interaction 2604142 Lysosome 2905322 Systemic lupus erythematosus 2804114 Oocyte meiosis 2605168 Herpes simplex infection 3103013 RNA transport 2905205 Proteoglycans in cancer 3100240 Pyrimidine metabolism 2404068 FoxO signaling pathway 2604510 Focal adhesion 3005161 Hepatitis B 2605202 Transcriptional misregulation in ca 2803040 Spliceosome 2401130 Biosynthesis of antibiotics 2904010 MAPK signaling pathway 3104014 Ras signaling pathway 2903440 Homologous recombination 1405206 MicroRNAs in cancer 3204914 Progesterone-mediated oocyte matu 1903018 RNA degradation 1804974 Protein digestion and absorption 1905146 Amoebiasis 2004062 Chemokine signaling pathway 2503410 Base excision repair 1304064 NF-kappa B signaling pathway 1805164 Influenza A 2304360 Axon guidance 2004210 Apoptosis 1705169 Epstein-Barr virus infection 2401230 Biosynthesis of amino acids 1603430 Mismatch repair 11

04015 Rap1 signaling pathway 2404024 cAMP signaling pathway 2303420 Nucleotide excision repair 1304060 Cytokine-cytokine receptor interact 2605160 Hepatitis C 1904916 Melanogenesis 1705215 Prostate cancer 1604145 Phagosome 2004668 TNF signaling pathway 1704611 Platelet activation 1804610 Complement and coagulation casca 1404621 NOD-like receptor signaling pathwa 1304919 Thyroid hormone signaling pathway 1705220 Chronic myeloid leukemia 1405145 Toxoplasmosis 1705152 Tuberculosis 2004020 Calcium signaling pathway 2000330 Arginine and proline metabolism 1205032 Morphine addiction 1505214 Glioma 1304380 Osteoclast differentiation 1704750 Inflammatory mediator regulation o 1505162 Measles 1704530 Tight junction 1704722 Neurotrophin signaling pathway 1604921 Oxytocin signaling pathway 1804910 Insulin signaling pathway 1704550 Signaling pathways regulating pluri 1704970 Salivary secretion 1400590 Arachidonic acid metabolism 1204261 Adrenergic signaling in cardiomyoc 1700564 Glycerophospholipid metabolism 1405219 Bladder cancer 1004144 Endocytosis 2205204 Chemical carcinogenesis 1304070 Phosphatidylinositol signaling syst 1304390 Hippo signaling pathway 1704915 Estrogen signaling pathway 1404120 Ubiquitin mediated proteolysis 1604071 Sphingolipid signaling pathway 1505142 Chagas disease (American trypanos 1400410 beta-Alanine metabolism 904976 Bile secretion 1205221 Acute myeloid leukemia 11

04540 Gap junction 1300980 Metabolism of xenobiotics by cyto 1200983 Drug metabolism - other enzymes 1004370 VEGF signaling pathway 1104810 Regulation of actin cytoskeleton 1905210 Colorectal cancer 1104726 Serotonergic synapse 1404650 Natural killer cell mediated cytotoxi 1505212 Pancreatic cancer 1105231 Choline metabolism in cancer 1305230 Central carbon metabolism in cance 1105120 Epithelial cell signaling in Helicobac 1104152 AMPK signaling pathway 1404012 ErbB signaling pathway 1204662 B cell receptor signaling pathway 1104912 GnRH signaling pathway 1204146 Peroxisome 1104066 HIF-1 signaling pathway 1200480 Glutathione metabolism 900270 Cysteine and methionine metaboli 804664 Fc epsilon RI signaling pathway 1005218 Melanoma 1004917 Prolactin signaling pathway 1000260 Glycine, serine and threonine meta 805323 Rheumatoid arthritis 1104725 Cholinergic synapse 1201200 Carbon metabolism 1204923 Regulation of lipolysis in adipocytes 905133 Pertussis 1004724 Glutamatergic synapse 1202010 ABC transporters 804022 cGMP-PKG signaling pathway 1400562 Inositol phosphate metabolism 905010 Alzheimer's disease 1404514 Cell adhesion molecules (CAMs) 1300280 Valine, leucine and isoleucine degr 800830 Retinol metabolism 904924 Renin secretion 904660 T cell receptor signaling pathway 1104080 Neuroactive ligand-receptor interac 1801212 Fatty acid metabolism 804620 Toll-like receptor signaling pathway 1104130 SNARE interactions in vesicular tra 700010 Glycolysis / Gluconeogenesis 9

00982 Drug metabolism - cytochrome P45 905031 Amphetamine addiction 900350 Tyrosine metabolism 704913 Ovarian steroidogenesis 805014 Amyotrophic lateral sclerosis (ALS) 800340 Histidine metabolism 601040 Biosynthesis of unsaturated fatty ac 604918 Thyroid hormone synthesis 905140 Leishmaniasis 905223 Non-small cell lung cancer 804310 Wnt signaling pathway 1204713 Circadian entrainment 1004670 Leukocyte transendothelial migrati 1100140 Steroid hormone biosynthesis 805016 Huntington's disease 1400561 Glycerolipid metabolism 804932 Non-alcoholic fatty liver disease (N 1200760 Nicotinate and nicotinamide metab 600600 Sphingolipid metabolism 704640 Hematopoietic cell lineage 905144 Malaria 700360 Phenylalanine metabolism 505414 Dilated cardiomyopathy 904727 GABAergic synapse 903320 PPAR signaling pathway 804622 RIG-I-like receptor signaling pathwa 805012 Parkinson's disease 1104141 Protein processing in endoplasmic 1205110 Vibrio cholerae infection 700040 Pentose and glucuronate interconve 604971 Gastric acid secretion 804270 Vascular smooth muscle contractio 1005134 Legionellosis 705150 Staphylococcus aureus infection 704960 Aldosterone-regulated sodium reab 604964 Proximal tubule bicarbonate reclam 504723 Retrograde endocannabinoid signal 904630 Jak-STAT signaling pathway 1104728 Dopaminergic synapse 1005410 Hypertrophic cardiomyopathy (HCM 804721 Synaptic vesicle cycle 705132 Salmonella infection 804911 Insulin secretion 803008 Ribosome biogenesis in eukaryotes 8

05131 Shigellosis 700053 Ascorbate and aldarate metabolism 500565 Ether lipid metabolism 605211 Renal cell carcinoma 704720 Long-term potentiation 703015 mRNA surveillance pathway 805216 Thyroid cancer 500790 Folate biosynthesis 400052 Galactose metabolism 505030 Cocaine addiction 604972 Pancreatic secretion 804520 Adherens junction 704978 Mineral absorption 600051 Fructose and mannose metabolism 504922 Glucagon signaling pathway 805130 Pathogenic Escherichia coli infectio 605217 Basal cell carcinoma 604260 Cardiac muscle contraction 700511 Other glycan degradation 400770 Pantothenate and CoA biosynthesis 404730 Long-term depression 600380 Tryptophan metabolism 500620 Pyruvate metabolism 504623 Cytosolic DNA-sensing pathway 604666 Fc gamma R-mediated phagocytosi 705321 Inflammatory bowel disease (IBD) 604977 Vitamin digestion and absorption 400592 alpha-Linolenic acid metabolism 404920 Adipocytokine signaling pathway 604961 Endocrine and other factor-regulat 504330 Notch signaling pathway 505412 Arrhythmogenic right ventricular 600030 Pentose phosphate pathway 400591 Linoleic acid metabolism 404744 Phototransduction 400130 Ubiquinone and other terpenoid-qui 300430 Taurine and hypotaurine metabolis 300310 Lysine degradation 505213 Endometrial cancer 504340 Hedgehog signaling pathway 500512 Mucin type O-Glycan biosynthesis 400500 Starch and sucrose metabolism 503450 Non-homologous end-joining 305143 African trypanosomiasis 4

00250 Alanine, aspartate and glutamate 405340 Primary immunodeficiency 405020 Prion diseases 400533 Glycosaminoglycan biosynthesis - k 305033 Nicotine addiction 400860 Porphyrin and chlorophyll metaboli 400531 Glycosaminoglycan degradation 303050 Proteasome 400071 Fatty acid degradation 400532 Glycosaminoglycan biosynthesis - ch 300670 One carbon pool by folate 304973 Carbohydrate digestion and absorpt 404940 Type I diabetes mellitus 404962 Vasopressin-regulated water reabso 404672 Intestinal immune network for IgA 404612 Antigen processing and presentatio 504350 TGF-beta signaling pathway 500290 Valine, leucine and isoleucine biosy 200062 Fatty acid elongation 304966 Collecting duct acid secretion 300650 Butanoate metabolism 300750 Vitamin B6 metabolism 204150 mTOR signaling pathway 405416 Viral myocarditis 404710 Circadian rhythm 300460 Cyanoamino acid metabolism 200072 Synthesis and degradation of keton 200920 Sulfur metabolism 204140 Regulation of autophagy 305330 Allograft rejection 304975 Fat digestion and absorption 303010 Ribosome 605100 Bacterial invasion of epithelial cells 405332 Graft-versus-host disease 303022 Basal transcription factors 304930 Type II diabetes mellitus 304740 Olfactory transduction 600910 Nitrogen metabolism 200450 Selenocompound metabolism 205320 Autoimmune thyroid disease 300220 Arginine biosynthesis 200100 Steroid biosynthesis 200190 Oxidative phosphorylation 500900 Terpenoid backbone biosynthesis 2

03060 Protein export 200534 Glycosaminoglycan biosynthesis - h 200563 Glycosylphosphatidylinositol(GPI)-a 200601 Glycosphingolipid biosynthesis - lac 204320 Dorso-ventral axis formation 200020 Citrate cycle (TCA cycle) 200514 Other types of O-glycan biosynthesi 203020 RNA polymerase 205310 Asthma 200520 Amino sugar and nucleotide sugar 200730 Thiamine metabolism 100603 Glycosphingolipid biosynthesis - glo 100604 Glycosphingolipid biosynthesis - gan 100232 Caffeine metabolism 100300 Lysine biosynthesis 104122 Sulfur relay system 100970 Aminoacyl-tRNA biosynthesis 100640 Propanoate metabolism 100120 Primary bile acid biosynthesis 104742 Taste transduction 201210 2-Oxocarboxylic acid metabolism 104614 Renin-angiotensin system 104950 Maturity onset diabetes of the youn 100630 Glyoxylate and dicarboxylate meta 100510 N-Glycan biosynthesis 2

Genes Sig.NotIn.KEGG Genome.In.KEG Genome.NotIn. PValue100, 100137049, 684 1220 38506 1.587482E-711017, 1026, 103 797 124 39602 9.414221E-381017, 1026, 103 775 398 39328 8.618526E-371017, 1026, 111 812 68 39658 4.907548E-2810014, 116444, 803 180 39546 8.356159E-2610014, 1017, 10 803 206 39520 6.6918E-2410535, 10714, 1 820 36 39690 1.071077E-23100, 10606, 106 806 175 39551 2.568546E-231026, 1031, 107 800 261 39465 4.078031E-231017, 1026, 103 796 347 39379 5.925402E-22116028, 146956, 820 53 39673 9.086841E-211017, 10319, 11 817 86 39640 4.64074E-2010319, 1281, 12 818 87 39639 6.74516E-1910053, 10312, 1 815 123 39603 1.050042E-18126961, 3014, 3 816 136 39590 8.737225E-171017, 115, 1516 818 113 39613 1.341998E-161017, 10189, 10 813 186 39540 2.606519E-1610189, 10460, 1 815 172 39554 2.091176E-151026, 1839, 206 813 204 39522 2.396177E-1510622, 10714, 1 820 105 39621 2.65798E-151017, 1026, 103 818 134 39592 4.243099E-1510319, 10451, 1 814 207 39519 2.14232E-141017, 1026, 164 818 146 39580 2.396705E-141026, 1031, 126 816 179 39547 3.447397E-1410189, 10465, 1 820 133 39593 2.166594E-1310606, 113675, 815 214 39512 2.733431E-13100137049, 1647 813 257 39469 5.6227E-13100137049, 1114 815 228 39498 1.100525E-1210714, 146956, 830 28 39698 1.266564E-121026, 113130, 1 812 297 39429 3.32824E-121017, 115, 2770, 825 88 39638 7.614273E-1210200, 11157, 1 826 77 39649 1.012792E-111281, 1282, 128 825 90 39636 1.056704E-1110319, 1281, 12 824 109 39617 2.335351E-1110344, 10451, 1 819 189 39537 2.40292E-1110038, 10039, 1 831 33 39693 9.198083E-11257397, 27040, 826 91 39635 1.01042E-1010379, 293, 310 821 177 39549 2.344201E-1010501, 1947, 19 824 127 39599 2.404306E-10317, 330, 355, 827 86 39640 3.774866E-1010014, 1017, 10 820 201 39525 4.038469E-10113675, 1373, 1 828 74 39652 4.710402E-1010714, 2956, 44 833 23 39703 8.550679E-10

115, 163688, 19 820 211 39515 9.554906E-1010451, 115, 116 821 200 39526 1.890095E-0910714, 1643, 54 831 47 39679 2.743349E-0910344, 2323, 29 818 265 39461 2.774302E-091026, 10379, 13 825 133 39593 2.987781E-09115, 163688, 19 827 101 39625 2.999845E-091017, 1026, 186 828 89 39637 4.413037E-0910312, 10376, 1 824 155 39571 4.804067E-091906, 2353, 257 827 110 39616 8.944205E-09100137049, 115, 826 131 39595 1.436385E-081675, 2153, 215 830 69 39657 1.464828E-0810910, 22861, 2 831 57 39669 1.786446E-08113026, 2648, 3 827 119 39607 2.430215E-081026, 1869, 187 830 73 39653 2.648018E-0810319, 240, 277 827 120 39606 2.701718E-0810312, 1263, 15 824 179 39547 3.992684E-08113026, 115, 14 824 180 39546 4.329456E-08112483, 217, 25 832 50 39676 4.746248E-08115, 2563, 2564 829 93 39633 5.131411E-081026, 163688, 1 831 65 39661 6.398517E-0810379, 2274, 23 827 131 39595 8.149067E-08100137049, 115, 829 99 39627 1.031587E-071017, 10379, 27 827 134 39592 1.081563E-071364, 154810, 2 827 138 39588 1.560271E-07163688, 25759, 828 120 39606 1.568864E-07100137049, 1026 826 159 39567 1.862731E-07163688, 1978, 2 827 140 39586 1.865567E-071852, 2260, 226 827 142 39584 2.224128E-07115, 1469, 147, 830 90 39636 2.355659E-07100137049, 1114 832 62 39664 3.221687E-07115, 147, 154, 827 149 39577 4.02639E-07100137049, 1114 830 95 39631 4.120616E-071026, 1869, 187 834 38 39688 4.651562E-0710938, 116983, 822 258 39468 4.954341E-0710720, 1545, 15 831 82 39644 6.024707E-07113026, 1606, 1 831 82 39644 6.024707E-071490, 27113, 33 827 154 39572 6.033115E-07115, 163688, 18 830 100 39626 6.985464E-0710054, 11065, 1 828 137 39589 7.366946E-07123099, 1509, 2 829 120 39606 8.606973E-072353, 2770, 345 830 104 39622 1.043817E-061806, 217, 218, 835 31 39695 1.169819E-06115, 123264, 20 832 72 39654 1.210626E-0611040, 1978, 32 833 57 39669 1.211509E-06

10376, 10383, 1 831 89 39637 1.317322E-0610720, 1545, 15 832 74 39652 1.541045E-0610720, 1806, 54 834 46 39680 1.871342E-06100137049, 2575 833 61 39665 2.09328E-0610451, 10788, 1 825 215 39511 2.206231E-062353, 2956, 332 833 62 39664 2.385934E-06100137049, 1644 830 114 39612 2.652424E-0610451, 2185, 25 829 134 39592 2.837327E-061869, 1870, 355 833 66 39660 3.94171E-06100137049, 1606 831 101 39625 4.35282E-062260, 2261, 326 833 67 39659 4.446289E-0610312, 1839, 29 833 68 39658 5.005897E-061978, 3172, 510 830 124 39602 6.165183E-061026, 1839, 197 832 87 39639 6.339091E-0610451, 2353, 32 833 72 39654 7.898923E-06100137049, 115, 832 92 39634 1.027376E-0511001, 196743, 833 82 39644 2.210014E-051026, 1906, 197 832 103 39623 2.696972E-052678, 2876, 287 835 51 39675 2.924159E-05113675, 1491, 1 836 38 39688 3.723168E-05100137049, 1045 834 70 39656 3.887493E-051026, 1869, 187 834 71 39655 4.300284E-052353, 25759, 32 834 72 39654 4.749492E-05113675, 1491, 2 836 40 39686 4.977526E-0510312, 2353, 29 833 91 39635 4.981226E-05115, 2353, 2770 832 113 39613 5.878465E-05113675, 1373, 2 832 113 39613 5.878465E-0511145, 115, 154 835 57 39669 5.966017E-05163688, 2353, 2 834 75 39651 6.3417E-05100137049, 115, 832 116 39610 7.310288E-0510057, 10347, 1 836 44 39682 8.527191E-05115, 147, 154, 1 830 167 39559 0.000109721113026, 3613, 3 835 63 39663 0.000112739163688, 2081, 2 830 168 39558 0.0001160021001, 1002, 136 831 145 39581 0.000117035217, 3155, 3157, 836 47 39679 0.00012359910720, 1551, 15 835 65 39661 0.000137352154, 163688, 27 835 65 39661 0.00013735210451, 2353, 27 833 104 39622 0.0001386391138, 116444, 1 826 275 39451 0.000151779201562, 34, 37, 836 49 39677 0.000156152353, 3551, 355 833 106 39620 0.00016012310228, 6809, 68 837 34 39692 0.0001661412026, 217, 218, 835 67 39659 0.000166234

10720, 1577, 21 835 68 39658 0.000182444116444, 163688, 835 68 39658 0.0001824441644, 218, 220, 837 35 39691 0.000191224100137049, 115, 836 51 39675 0.0001953122876, 2905, 317 836 51 39675 0.0001953121644, 217, 218, 838 23 39703 0.000252968201562, 54898, 838 23 39703 0.000252968115, 2876, 2877, 835 72 39654 0.0002608232353, 3109, 345 835 74 39652 0.0003092641869, 1870, 274 836 56 39670 0.00032860827101, 4316, 54 832 140 39586 0.000337254115, 163688, 23 834 96 39630 0.00035198210451, 1364, 21 833 118 39608 0.00035663310720, 1545, 15 836 58 39668 0.00039896127602, 27113, 830 193 39533 0.0004113311606, 217, 231, 836 59 39667 0.0004383851649, 2081, 355 832 151 39575 0.000611368133686, 23057, 838 29 39697 0.000646217123099, 2717, 3 837 47 39679 0.0007907652323, 3553, 355 835 87 39639 0.0008334863553, 3576, 403 837 49 39677 0.0009641681644, 218, 220, 839 18 39708 0.001004762115, 3673, 3675 835 90 39636 0.001022149115, 2563, 2564 835 90 39636 0.00102214911001, 2171, 34 836 69 39657 0.001029472338376, 3551, 3 836 70 39656 0.0011124262770, 2861, 293 833 143 39583 0.0014225581410, 1649, 208 832 169 39557 0.00144563910312, 115, 299 837 54 39672 0.00152565510720, 217, 231 838 36 39690 0.001544258115, 163688, 27 836 75 39651 0.001608925100137049, 115, 834 121 39605 0.0016333152919, 317, 3553 837 55 39671 0.0016627921675, 2266, 310 837 57 39669 0.0019649282810, 3845, 478 838 39 39687 0.002126417478, 483, 486, 839 23 39703 0.002220298115, 2563, 2564 835 103 39623 0.00226883710252, 10379, 3 833 156 39570 0.002594368163688, 1644, 2 834 131 39595 0.0027083983673, 3675, 369 836 83 39643 0.00274330810312, 10814, 5 837 63 39663 0.0031226422353, 2919, 299 836 86 39640 0.003298435115, 3783, 478, 836 86 39640 0.00329843510436, 10940, 1 836 87 39639 0.003501291

3551, 3576, 479 837 65 39661 0.00360312310720, 217, 501 839 27 39699 0.003728095100137049, 1114 838 45 39681 0.0037465072271, 3265, 384 837 66 39660 0.003862955163688, 2905, 3 837 67 39659 0.00413640810189, 23293, 2 836 91 39635 0.0044090013265, 3845, 489 839 29 39697 0.0046923481719, 249, 2643 840 14 39712 0.004890799231, 2548, 2582 839 30 39696 0.005231832116444, 1644, 2 838 50 39676 0.005651906115, 478, 483, 836 96 39630 0.005780984117178, 2260, 6 837 73 39653 0.00608667530061, 4502, 47 838 51 39675 0.006101982231, 2762, 5210 839 32 39694 0.006431927163688, 5106, 5 836 102 39624 0.00782171210376, 10383, 2 838 55 39671 0.0081548872735, 54361, 74 838 55 39671 0.008154887478, 483, 486, 837 78 39648 0.0081634212517, 4125, 412 840 18 39708 0.0089946041806, 5167, 533 840 18 39708 0.008994604100137049, 2770 838 60 39666 0.0113376991545, 1644, 217 839 40 39686 0.013015789217, 2271, 2739 839 40 39686 0.01301578910622, 3551, 35 838 64 39662 0.01442439100137049, 1045 837 92 39634 0.016611813109, 3459, 355 838 67 39659 0.0170777526573, 80704, 94 840 24 39702 0.018045595100137049, 111 840 25 39701 0.0199052843551, 4792, 510 838 70 39656 0.020035891115, 478, 483, 839 48 39678 0.02281189510683, 151636, 839 48 39678 0.0228118953673, 3675, 369 838 74 39652 0.0244744222934, 5211, 56 840 29 39697 0.028359586100137049, 111 840 29 39697 0.028359586163688, 408, 51 840 29 39697 0.028359586154807, 27235, 841 11 39715 0.0289038682678, 51380, 57 841 11 39715 0.028903868217, 501, 6839, 839 52 39674 0.0290225633265, 3845, 489 839 52 39674 0.0290225632735, 53944, 54 839 52 39674 0.02902256311227, 114805, 840 31 39695 0.03319351710720, 2548, 51 839 56 39670 0.0361418872237, 27343, 75 841 13 39713 0.0378624412150, 355, 3553 840 34 39692 0.041191421

122622, 1373, 4 840 35 39691 0.044053405100, 6890, 7374 840 36 39690 0.0470117783553, 5613, 581 840 36 39690 0.04701177811041, 8702, 94 841 15 39711 0.047726519116444, 2563, 2 840 40 39686 0.059785878310720, 1356, 54 840 42 39684 0.0667189305138050, 3425, 6 841 19 39707 0.06981920535684, 5696, 572 840 44 39682 0.0740004758217, 34, 37, 501 840 44 39682 0.074000475826229, 51363, 841 20 39706 0.075775510110797, 1719, 64 841 20 39706 0.0757755101478, 483, 486, 840 45 39681 0.07776799631363, 3109, 355 840 45 39681 0.0777679963115, 360, 5613, 840 45 39681 0.077767996323308, 3109, 36 840 49 39677 0.09364408331520, 3109, 572 839 79 39647 0.09466339413400, 3625, 593 839 80 39646 0.0978540566113675, 586 842 4 39722 0.0996727278201562, 54898, 841 25 39701 0.107695435110312, 527, 911 841 27 39699 0.12130644913155, 3157, 659 841 27 39699 0.1213064491316, 55163 842 6 39720 0.1367054931978, 3551, 529 840 60 39666 0.14316195873109, 54205, 71 840 60 39666 0.14316195871407, 5564, 855 841 31 39695 0.14964512682678, 6470 842 7 39719 0.15464734173155, 3157 842 10 39716 0.206268905254205, 7263 842 10 39716 0.206268905283734, 89849, 9 841 39 39687 0.20937810823109, 355, 958 841 39 39687 0.209378108219, 84649, 949 841 41 39685 0.2246944925200916, 23521, 838 137 39589 0.224809404525759, 5296, 64 840 78 39648 0.23734961113109, 355, 3553 841 43 39683 0.24008968876875, 6877, 838 841 45 39681 0.2555313513551, 5296, 559 841 48 39678 0.2787163792143503, 163688, 838 407 39319 0.29427693671373, 768 842 17 39709 0.31480391521491, 22929 842 17 39709 0.31480391523109, 355, 958 841 54 39672 0.3248480971373, 445 842 20 39706 0.356655600410682, 7108 842 20 39706 0.356655600410312, 4731, 51 839 133 39593 0.374091950323590, 3157 842 22 39704 0.3831283346

196294, 29927 842 23 39703 0.395953836926035, 26229 842 24 39702 0.40851299135277, 80055 842 25 39701 0.420811322711041, 8702 842 26 39700 0.43285424142114, 3845 842 27 39699 0.44464704582271, 5106 842 30 39696 0.47857612215986, 84620 842 31 39695 0.489419289710622, 84265 842 32 39694 0.50003723233109, 958 842 32 39694 0.50003723232582, 2762 842 48 39678 184284 843 4 39722 12717 843 14 39712 12583 843 15 39711 17498 843 5 39721 1501 843 2 39724 17263 843 10 39716 155157 843 66 39660 134 843 28 39698 1570 843 17 39709 13745, 5613 842 53 39673 1586 843 17 39709 157486 843 17 39709 13172 843 25 39701 16470 843 28 39698 184620, 84920 842 49 39677 1

Bonferroni FDR "-logP"4.571948E-69 4.571948E-69 70.799292.711296E-35 1.355648E-35 37.026222.482135E-34 8.273785E-35 36.064571.413374E-25 3.533434E-26 27.309142.406574E-23 4.813147E-24 25.077991.927238E-21 3.212064E-22 23.174463.084702E-21 4.406717E-22 22.970187.397414E-21 9.246767E-22 22.590311.174473E-20 1.30497E-21 22.389551.706516E-19 1.706516E-20 21.227282.61701E-18 2.3791E-19 20.04159

1.336533E-17 1.113777E-18 19.333411.942606E-16 1.494312E-17 18.171013.024122E-16 2.160087E-17 17.978792.516321E-14 1.677547E-15 16.058633.864955E-14 2.415597E-15 15.872257.506774E-14 4.415749E-15 15.583946.022586E-13 3.345881E-14 14.679616.900991E-13 3.6321E-14 14.620487.654984E-13 3.827492E-14 14.575451.222012E-12 5.819107E-14 14.372326.169883E-12 2.804492E-13 13.669126.902511E-12 3.001092E-13 13.620399.928503E-12 4.136876E-13 13.462516.23979E-11 2.495916E-12 12.66422

7.872282E-11 3.027801E-12 12.563291.619338E-10 5.997546E-12 12.250063.169512E-10 1.131969E-11 11.95843.647704E-10 1.257829E-11 11.897379.585332E-10 3.195111E-11 11.477792.192911E-09 7.073905E-11 11.118372.916841E-09 9.115129E-11 10.994483.043307E-09 9.222142E-11 10.976056.725809E-09 1.97726E-10 10.631656.92041E-09 1.97726E-10 10.61926

2.649048E-08 7.358466E-10 10.03632.91001E-08 7.864891E-10 9.995498

6.751299E-08 1.775487E-09 9.6300056.924401E-08 1.775487E-09 9.619011.087161E-07 2.717903E-09 9.4230991.163079E-07 2.836778E-09 9.3937831.356596E-07 3.22999E-09 9.3269422.462595E-07 5.726966E-09 9.067999

2.751813E-07 6.25412E-09 9.0197745.443472E-07 1.20966E-08 8.7235167.900845E-07 1.699998E-08 8.5617197.989989E-07 1.699998E-08 8.5568468.604809E-07 1.763174E-08 8.5246518.639553E-07 1.763174E-08 8.5229011.270955E-06 2.541909E-08 8.3552621.383571E-06 2.712885E-08 8.3183912.575931E-06 4.953713E-08 8.0484584.13679E-06 7.805264E-08 7.842729

4.218704E-06 7.812415E-08 7.8342135.144966E-06 9.354483E-08 7.748016.999018E-06 1.249825E-07 7.6143557.62629E-06 1.337946E-07 7.577079

7.780948E-06 1.341543E-07 7.568361.149893E-05 1.948971E-07 7.3987351.246883E-05 2.078139E-07 7.3635671.366919E-05 2.240852E-07 7.323651.477846E-05 2.383623E-07 7.2897631.842773E-05 2.925036E-07 7.1939212.346931E-05 3.66708E-07 7.0888922.970971E-05 4.570725E-07 6.9864943.114901E-05 4.719546E-07 6.9659484.49358E-05 6.644602E-07 6.8068

4.518329E-05 6.644602E-07 6.8044155.364667E-05 7.675475E-07 6.729855.372832E-05 7.675475E-07 6.7291896.405489E-05 9.021815E-07 6.652846.784297E-05 9.422635E-07 6.6278889.278458E-05 1.271022E-06 6.4919170.00011596 1.567028E-06 6.395084

0.000118674 1.582317E-06 6.3850380.000133965 1.762697E-06 6.3324010.000142685 1.853052E-06 6.3050140.000173512 2.171921E-06 6.2200640.000173512 2.171921E-06 6.2200640.000173754 2.171921E-06 6.2194580.000201181 2.483721E-06 6.1558050.000212168 2.587415E-06 6.1327130.000247881 2.986516E-06 6.065150.000300619 3.578801E-06 5.9813760.000336908 3.963622E-06 5.9318810.00034866 4.010512E-06 5.91699

0.000348915 4.010512E-06 5.916673

0.000379389 4.311235E-06 5.8803080.000443821 4.986751E-06 5.8121850.000538946 5.988294E-06 5.7278470.000602865 6.624886E-06 5.6791730.000635395 6.906463E-06 5.6563490.000687149 7.388697E-06 5.6223420.000763898 8.126577E-06 5.5763570.00081715 8.601581E-06 5.547091

0.001135212 1.182513E-05 5.4043150.001253612 1.292384E-05 5.3612290.001280531 1.306665E-05 5.3520020.001441698 1.456261E-05 5.3005180.001775573 1.775573E-05 5.2100540.001825658 1.807583E-05 5.1979730.00227489 2.230284E-05 5.102432

0.002958842 2.872662E-05 4.9882710.00636484 6.120038E-05 4.655605

0.007767279 7.397409E-05 4.5691240.008421578 7.944885E-05 4.5339990.010722725 0.000100212 4.4290870.01119598 0.000103666 4.41033

0.012384817 0.000113622 4.3665030.013678538 0.00012435 4.3233530.014335275 0.000128089 4.3029860.014345931 0.000128089 4.3026640.016929979 0.000148509 4.2307360.016929979 0.000148509 4.2307360.017182128 0.00014941 4.2243160.018264097 0.000157449 4.1977940.021053629 0.000179946 4.1360660.024558309 0.000208121 4.0691940.031599698 0.000265544 3.959710.032468813 0.000270573 3.9479260.033408665 0.000276105 3.9355330.033706219 0.00027628 3.9316820.035596421 0.000289402 3.9079860.039557463 0.00031646 3.8621640.039557463 0.00031646 3.8621640.039927963 0.000316889 3.8581150.043712318 0.000344191 3.8187890.044971194 0.000351337 3.8064580.046115361 0.000357483 3.7955470.047848549 0.00036546 3.7795240.047875259 0.00036546 3.779281

0.0525440143 0.000395068 3.7388690.0525440143 0.000395068 3.7388690.0550724546 0.000410988 3.7184580.0562499256 0.000413602 3.7092710.0562499256 0.000413602 3.7092710.0728546588 0.000527932 3.5969350.0728546588 0.000527932 3.5969350.0751171118 0.000540411 3.5836540.0890680132 0.0006362 3.5096710.0946391269 0.000671199 3.4833220.0971292899 0.000684009 3.4720420.1013709372 0.000708888 3.4534790.1027101688 0.000713265 3.4477790.1149005836 0.000792418 3.399070.1184634164 0.000811393 3.3858080.1262550051 0.000858878 3.3581440.1760740641 0.00118969 3.2136970.1861103963 0.001249063 3.1896220.2277403803 0.001518269 3.1019520.2400440563 0.001589696 3.0791020.2776803664 0.001826845 3.0158470.2893715181 0.001891317 2.9979370.2943788698 0.001899219 2.9904860.2943788698 0.001899219 2.9904860.2964879965 0.001900564 2.9873850.3203787592 0.002040629 2.9537290.4096968004 0.002593018 2.846930.4163441448 0.002618517 2.839940.4393886789 0.002746179 2.816544

0.444746439 0.0027624 2.811280.4633704801 0.002860312 2.7934640.4703946373 0.002885857 2.786930.4788842295 0.002920026 2.779162

0.565899129 0.003429692 2.7066530.6124079987 0.003689205 2.6723520.6394457452 0.003829016 2.6535890.6534251268 0.003889435 2.644197

0.747177994 0.004421172 2.5859680.7800186236 0.004588345 2.5672880.7900726586 0.004620308 2.5617250.8993208718 0.00522861 2.5054780.9499491713 0.005459478 2.4816920.9499491713 0.005459478 2.481692

1 0.005762124 2.455772

1 0.005896019 2.4433211 0.006061764 2.4285131 0.006061764 2.4263731 0.006215258 2.413081 0.006618252 2.3833771 0.007015427 2.355661 0.007425253 2.328611 0.007696995 2.310621 0.008188954 2.2813461 0.008798643 2.2478051 0.008951201 2.2379981 0.009347718 2.215621 0.009347718 2.2145291 0.009801032 2.1916591 0.011856069 2.1066981 0.012181685 2.0885821 0.012181685 2.0885821 0.012181685 2.0881281 0.013284338 2.0460181 0.013284338 2.0460181 0.016659476 1.9454751 0.018932057 1.885531 0.018932057 1.885531 0.020875499 1.8409031 0.023921007 1.7795831 0.024469615 1.7675691 0.025728373 1.7436291 0.028240009 1.7010321 0.028285964 1.6981911 0.031892358 1.6418391 0.031892358 1.6418391 0.034051367 1.6112881 0.038876735 1.54731 0.038876735 1.54731 0.038876735 1.54731 0.038876735 1.5390441 0.038876735 1.5390441 0.038876735 1.5372641 0.038876735 1.5372641 0.038876735 1.5372641 0.044258023 1.4789471 0.047967113 1.4419891 0.0500201051 1.4217911 0.0541695404 1.385193

1 0.057669912 1.3560211 0.0609882528 1.3277931 0.0609882528 1.3277931 0.0616378356 1.321241 0.0768675578 1.2234011 0.0854002311 1.1757511 0.0889731466 1.1560251 0.0934742852 1.1307651 0.0934742852 1.1307651 0.0948841169 1.1204711 0.0948841169 1.1204711 0.0961252487 1.1091991 0.0961252487 1.1091991 0.0961252487 1.1091991 0.1152542564 1.028521 0.1160130106 1.0238181 0.1194151199 1.0094211 0.1211212895 1.0014241 0.1303205265 0.9678031 0.1455677389 0.9161161 0.1455677389 0.9161161 0.1633659003 0.8642141 0.1696734325 0.8441721 0.1696734325 0.8441721 0.1766303136 0.8249371 0.1817895283 0.8106581 0.2405078733 0.6855661 0.2405078733 0.6855661 0.2421722697 0.6790691 0.2421722697 0.6790691 0.2579486394 0.6484081 0.2579486394 0.6481861 0.2712566984 0.6246111 0.2733036773 0.6196261 0.289736335 0.5925561 0.3147855577 0.5548381 0.3310615538 0.5312441 0.3514090216 0.501961 0.3514090216 0.501961 0.36122105 0.488321 0.3935510074 0.4477511 0.3935510074 0.4477511 0.4112155789 0.4270221 0.4195473778 0.416656

1 0.4319496402 0.4023551 0.4439688358 0.3887941 0.4556152667 0.3759131 0.4668989571 0.3636581 0.4778296612 0.3519851 0.5123788965 0.3200491 0.5220472423 0.3103191 0.5294511871 0.3009981 0.5294511871 0.3009981 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 01 1 0

Gene_ID Transcript_ID Gene_Symbol1606 NM_201444,NM_20DGKA218 NM_001135168,NMALDH3A1340485 NM_001010887 ACER27108 NR_102367,NM_00TM7SF23425 NM_000203,NR_11IDUA2593 NM_138924,NM_00GAMT1577 NM_001291829,NMCYP3A55625 NM_001195226,NMPRODH203 NM_000476 AK164900 NR_126051,NM_00LPIN310720 NM_001073 UGT2B1155191 NM_018161 NADSYN129785 NM_030622 CYP2S12548 NM_001079804,NMGAA50484 NM_015713,NM_00RRM2B7498 NM_000379 XDH445 NM_000050,NM_05ASS13628 NM_001128928,NMINPP16303 NM_002970,NR_02SAT1134147 NM_138809 CMBL8605 NM_001159323,NMPLA2G4C8974 NM_001017973,NMP4HA2272 NM_001025389,NMAMPD351380 NM_001244706,NMCSAD11227 NM_014568 GALNT55224 NM_000290 PGAM2978 NM_001785 CDA23646 NM_012268,NM_00PLD379586 NM_001195731,NMCHPF84265 NM_032305 POLR3GL80271 NM_025194 ITPKC54658 NM_000463 UGT1A12582 NM_001008216,NMGALE4051 NM_000896,NM_00CYP4F353354 NM_148977,NM_14PANK1113026 NM_133373 PLCD380055 NM_024989 PGAP155163 NM_018129 PNPO55361 NM_018425 PI4K2A316 NM_001159 AOX16448 NM_000199 SGSH7263 NM_001270483,NMTST23057 NM_170706,NM_01NMNAT2

57104 NM_020376 PNPLA2654364 NM_001018136,NRNME1-NME29249 NM_004753 DHRS33155 NM_000191,NM_00HMGCL51084 NM_015974 CRYL19536 NM_004878 PTGES501 NM_001202404,NMALDH7A111041 NM_006876 B3GNT1113675 NM_138432 SDSL5211 NM_001002021,NMPFKL100 NM_000022 ADA217 NM_001204889,NMALDH28398 NM_003560,NM_00PLA2G654981 NM_017881,NR_02NMRK137 NM_001270447,NMACADVL84284 NM_032324 NTPCR240 NM_001256153,NMALOX5527 NM_001694,NM_00ATP6V0C3293 NM_000197 HSD17B3122622 NM_199165,NM_15ADSSL12937 NM_000178 GSS1551 NM_000765 CYP3A76609 NM_000543,NM_00SMPD110312 NM_006019,NM_00TCIRG151079 NM_015965 NDUFA1391012 NM_001281731,NMCERS5100137049NM_001114633 PLA2G4B112483 NM_133491 SAT254490 NM_001207004,NMUGT2B284830 NM_000269,NM_19NME19114 NM_004691 ATP6V0D1231 NM_001628 AKR1B19245 NM_004751 GCNT3220 NM_001293815,NMALDH1A3221 NM_001030010,NMALDH3B126229 NR_109991,NM_01B3GAT32026 NM_001975 ENO25298 NM_002651,NM_00PI4KB23382 NM_001130722,NMAHCYL22643 NM_001024070,NMGCH1427 NM_177924,NM_00ASAH1138050 NM_152419 HGSNAT11145 NM_001128203,NMPLA2G162678 NM_001288833,NMGGT1

84649 NM_032564,NM_00DGAT23706 NM_002220 ITPKA5743 NM_000963 PTGS2249 NM_001177520,NMALPL4731 NM_021075,NM_00NDUFV3

Gene_Description A549R/A549.fcdiacylglycerol kinase, alpha 80kDa 15.120257aldehyde dehydrogenase 3 family, member A1 11.781939alkaline ceramidase 2 9.847434transmembrane 7 superfamily member 2 9.835725iduronidase, alpha-L- 8.255982guanidinoacetate N-methyltransferase 7.447817cytochrome P450 3A5 isoform 3 7.338817proline dehydrogenase (oxidase) 1 7.209321adenylate kinase 1 6.034416lipin 3 5.932261UDP glucuronosyltransferase 2 family, polypeptide B11 5.712710NAD synthetase 1 5.493776cytochrome P450, family 2, subfamily S, polypeptide 1 5.352737glucosidase, alpha; acid 5.112537ribonucleotide reductase M2 B (TP53 inducible) 4.707313xanthine dehydrogenase 4.474281argininosuccinate synthase 1 4.137179inositol polyphosphate-1-phosphatase 3.998540spermidine/spermine N1-acetyltransferase 1 3.924577carboxymethylenebutenolidase homolog (Pseudomonas) 3.747646phospholipase A2, group IVC (cytosolic, calcium-independent) 3.739856prolyl 4-hydroxylase, alpha polypeptide II 3.715031adenosine monophosphate deaminase 3 3.509961cysteine sulfinic acid decarboxylase 3.269477UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosa 3.258357phosphoglycerate mutase 2 (muscle) 3.235331cytidine deaminase 3.233298phospholipase D3 3.201037chondroitin polymerizing factor 3.053714polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 3.053221inositol-trisphosphate 3-kinase C 3.025710UDP glucuronosyltransferase 1 family, polypeptide A1 3.024018UDP-galactose-4-epimerase 2.942462cytochrome P450, family 4, subfamily F, polypeptide 3 2.926818pantothenate kinase 1 2.899232phospholipase C, delta 3 2.822104post-GPI attachment to proteins 1 2.791956pyridoxamine 5'-phosphate oxidase 2.759414phosphatidylinositol 4-kinase type 2 alpha 2.752133aldehyde oxidase 1 2.726010N-sulfoglucosamine sulfohydrolase 2.716412thiosulfate sulfurtransferase (rhodanese) 2.706905nicotinamide nucleotide adenylyltransferase 2 2.647530

patatin-like phospholipase domain containing 2 2.642468NME1-NME2 readthrough 2.585619dehydrogenase/reductase (SDR family) member 3 2.5810973-hydroxymethyl-3-methylglutaryl-CoA lyase 2.533359crystallin, lambda 1 2.483947prostaglandin E synthase 2.443066aldehyde dehydrogenase 7 family, member A1 2.422436UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 2.372527serine dehydratase-like 2.322690ATP-dependent 6-phosphofructokinase, liver type isoform a 2.315860adenosine deaminase 2.313978aldehyde dehydrogenase 2 family (mitochondrial) 2.306490phospholipase A2, group VI (cytosolic, calcium-independent) 2.286566nicotinamide riboside kinase 1 2.282676acyl-CoA dehydrogenase, very long chain 2.282055nucleoside-triphosphatase, cancer-related 2.274426arachidonate 5-lipoxygenase 2.266565ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.265755hydroxysteroid (17-beta) dehydrogenase 3 2.244921adenylosuccinate synthase like 1 2.236382glutathione synthetase 2.236314cytochrome P450, family 3, subfamily A, polypeptide 7 2.235641sphingomyelin phosphodiesterase 1, acid lysosomal 2.233488T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 2.225455NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 2.222492ceramide synthase 5 2.210722phospholipase A2, group IVB (cytosolic) 2.200097spermidine/spermine N1-acetyltransferase family member 2 2.194463UDP glucuronosyltransferase 2 family, polypeptide B28 2.190602NME/NM23 nucleoside diphosphate kinase 1 2.173730ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.167275aldo-keto reductase family 1, member B1 (aldose reductase) 2.159558glucosaminyl (N-acetyl) transferase 3, mucin type 2.139019aldehyde dehydrogenase family 1 member A3 isoform 2 2.120988aldehyde dehydrogenase family 3 member B1 isoform c 2.113129galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 2.110689enolase 2 (gamma, neuronal) 2.107404phosphatidylinositol 4-kinase, catalytic, beta 2.098771adenosylhomocysteinase-like 2 2.073525GTP cyclohydrolase 1 2.042064N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.026437heparan-alpha-glucosaminide N-acetyltransferase 2.021342phospholipase A2, group XVI 2.018011gamma-glutamyltransferase 1 2.017336

diacylglycerol O-acyltransferase 2 2.016733inositol-trisphosphate 3-kinase A 2.010456prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthas 2.004486alkaline phosphatase, liver/bone/kidney 2.003285NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 2.003065

PValue Bonferroni FDR "-logP"1.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.79929

1.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.79929

1.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.799291.59E-71 4.57195E-69 4.57E-69 70.79929

Metabolism Count %Metabolism of xenobiotics by cytochrome P450 9 10.2Drug metabolism 9 10.2Arginine and proline metabolism 8 9.1Glycolysis / Gluconeogenesis 8 9.1Drug metabolism 7 8Ascorbate and aldarate metabolism 5 5.7Pentose and glucuronate interconversions 5 5.7Retinol metabolism 7 8Arachidonic acid metabolism 7 8Lysosome 9 10.2Steroid hormone biosynthesis 6 6.8Histidine metabolism 5 5.7Glycerolipid metabolism 5 5.7Galactose metabolism 4 4.5Purine metabolism 8 9.1Linoleic acid metabolism 4 4.5Androgen and estrogen metabolism 4 4.5Phosphatidylinositol signaling system 5 5.7Starch and sucrose metabolism 4 4.5Valine, leucine and isoleucine degradation 4 4.5Tyrosine metabolism 4 4.5Glycosaminoglycan degradation 3 3.4Phenylalanine metabolism 3 3.4Inositol phosphate metabolism 4 4.5Nicotinate and nicotinamide metabolism 3 3.4Vitamin B6 metabolism 2 2.3Porphyrin and chlorophyll metabolism 3 3.4Butanoate metabolism 3 3.4

P-Value Benjamini "-logP"2.30E-06 1.90E-04 5.6382723.00E-06 1.20E-04 5.5228791.10E-05 3.10E-04 4.9586072.60E-05 5.30E-04 4.5850273.60E-05 5.90E-04 4.4436979.50E-05 1.30E-03 4.0222761.20E-04 1.40E-03 3.9208191.30E-04 1.40E-03 3.8860571.60E-04 1.50E-03 3.795883.20E-04 2.60E-03 3.494855.50E-04 4.10E-03 3.2596378.20E-04 5.60E-03 3.0861864.30E-03 2.70E-02 2.3665326.50E-03 3.80E-02 2.1870877.50E-03 4.00E-02 2.1249398.00E-03 4.10E-02 2.096911.70E-02 8.10E-02 1.7695512.40E-02 1.10E-01 1.6197892.40E-02 1.00E-01 1.6197892.70E-02 1.10E-01 1.5686362.70E-02 1.10E-01 1.5686363.90E-02 1.40E-01 1.4089354.20E-02 1.50E-01 1.3767514.60E-02 1.60E-01 1.3372424.90E-02 1.60E-01 1.3098048.60E-02 2.60E-01 1.0655028.60E-02 2.50E-01 1.0655029.10E-02 2.50E-01 1.040959

Gene_ID Transcript_ID Gene_Symbol5538 NM_001142604,NM_0PPT126035 NM_015554 GLCE34 NM_001286043,NM_0ACADM5167 NM_006208 ENPP184920 NM_032834 ALG10875 NM_000071,NM_0011CBS123099 NM_206918 DEGS2133686 NM_001085411,NM_0NADK25634 NM_002765,NM_0010PRPS254205 NM_018947 CYCS5106 NM_001018073,NM_0PCK251196 NM_001165979,NM_0PLCE122929 NM_001195604,NM_0SEPHS122934 NM_144563 RPIA5198 NM_012393 PFAS6611 NM_004595,NM_0012SMS5631 NM_002764,NM_0012PRPS11789 NM_006892,NM_1758DNMT3B10606 NM_006452,NM_0010PAICS1373 NM_001875,NM_0011CPS12762 NM_001500,NM_0012GMDS586 NM_001178094,NM_0BCAT1114805 NM_052917,NM_0013GALNT131806 NM_000110,NM_0011DPYD8833 NM_003875 GMPS58510 NM_021232 PRODH227235 NM_015697 COQ254107 NR_027261,NM_0174POLE356994 NM_020244 CHPT15831 NM_001282281,NM_0PYCR15277 NR_033835,NR_0338 PIGA2271 NM_000143 FH7378 NR_109837,NM_0033UPP1874 NM_001236 CBR32583 NM_001276468,NM_0B4GALNT110682 NM_006579 EBP5424 NR_046402,NM_0012POLD16240 NM_001033 RRM110797 NR_027405,NM_0066MTHFD21491 NM_001190463,NM_1CTH1854 NM_001948,NM_0010DUT8702 NM_212543,NM_0037B4GALT484620 NM_001142352,NM_0ST6GAL2

1786 NM_001130823,NM_0DNMT1570 NM_001127610,NM_0BAAT10714 NR_046409,NM_0065POLD33242 NM_001171993,NM_0HPD3157 NM_002130,NM_0010HMGCS179623 NM_001253827,NR_0GALNT143613 NM_014214 IMPA25426 NM_006231 POLE5558 NM_001282487,NM_0PRIM279814 NM_024758 AGMAT3081 NM_000187 HGD1633 NM_000788 DCK440 NM_133436,NM_1833ASNS6470 NM_004169,NM_1489SHMT15422 NM_016937 POLA110622 NM_006467 POLR3G1644 NM_000790,NM_0012DDC23649 NM_002689 POLA21841 NM_012145,NR_0332DTYMK1719 NM_001290354,NR_1DHFR26227 NM_006623 PHGDH5427 NM_001197330,NM_0POLE25557 NM_000946 PRIM17083 NM_003258 TK16241 NM_001034,NM_0011RRM2

Gene_Description A549R/A549.fcpalmitoyl-protein thioesterase 1 -2.001688glucuronic acid epimerase -2.003931acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.028995ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.061309ALG10, alpha-1,2-glucosyltransferase -2.066375cystathionine-beta-synthase -2.096383delta(4)-desaturase, sphingolipid 2 -2.103559NAD kinase 2, mitochondrial -2.112301phosphoribosyl pyrophosphate synthetase 2 -2.116697cytochrome c, somatic -2.120496phosphoenolpyruvate carboxykinase [GTP], mitochondrial is -2.161655phospholipase C, epsilon 1 -2.166000selenophosphate synthetase 1 -2.180341ribose 5-phosphate isomerase A -2.188763phosphoribosylformylglycinamidine synthase -2.204897spermine synthase -2.216852phosphoribosyl pyrophosphate synthetase 1 -2.288134DNA (cytosine-5-)-methyltransferase 3 beta -2.304608phosphoribosylaminoimidazole carboxylase, phosphoribosyl -2.328494carbamoyl-phosphate synthase 1, mitochondrial -2.348387GDP-mannose 4,6-dehydratase -2.350671branched chain amino-acid transaminase 1, cytosolic -2.352393polypeptide N-acetylgalactosaminyltransferase 13 isoform 2 -2.354805dihydropyrimidine dehydrogenase -2.372645guanine monphosphate synthase -2.380806proline dehydrogenase (oxidase) 2 -2.430404coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.436269polymerase (DNA directed), epsilon 3, accessory subunit -2.457822choline phosphotransferase 1 -2.460461pyrroline-5-carboxylate reductase 1 -2.484295phosphatidylinositol glycan anchor biosynthesis, class A -2.507850fumarate hydratase -2.511301uridine phosphorylase 1 -2.615837carbonyl reductase 3 -2.682146beta-1,4-N-acetyl-galactosaminyl transferase 1 -2.747336emopamil binding protein (sterol isomerase) -2.786417polymerase (DNA directed), delta 1, catalytic subunit -2.844928ribonucleotide reductase M1 -2.847884methylenetetrahydrofolate dehydrogenase (NADP+ dependent -2.866815cystathionase (cystathionine gamma-lyase) -2.867201deoxyuridine triphosphatase -2.876116UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypep -2.964952ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -2.979017

DNA (cytosine-5-)-methyltransferase 1 -3.109863bile acid CoA: amino acid N-acyltransferase (glycine N-choloy -3.163426polymerase (DNA-directed), delta 3, accessory subunit -3.1819614-hydroxyphenylpyruvate dioxygenase -3.3958693-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.485415UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylga -3.525362inositol(myo)-1(or 4)-monophosphatase 2 -3.577570polymerase (DNA directed), epsilon, catalytic subunit -3.632382primase, DNA, polypeptide 2 (58kDa) -3.947016agmatine ureohydrolase (agmatinase) -3.977463homogentisate 1,2-dioxygenase -4.119843deoxycytidine kinase -4.348967asparagine synthetase (glutamine-hydrolyzing) -4.429006serine hydroxymethyltransferase 1 (soluble) -4.487330polymerase (DNA directed), alpha 1, catalytic subunit -4.732449polymerase (RNA) III (DNA directed) polypeptide G (32kD) -4.961536dopa decarboxylase (aromatic L-amino acid decarboxylase) -5.096665polymerase (DNA directed), alpha 2, accessory subunit -5.100242deoxythymidylate kinase (thymidylate kinase) -5.203735dihydrofolate reductase isoform 2 -7.632527phosphoglycerate dehydrogenase -9.018869polymerase (DNA directed), epsilon 2, accessory subunit -9.746748primase, DNA, polypeptide 1 (49kDa) -10.282687thymidine kinase 1, soluble -19.775536ribonucleotide reductase M2 -36.412889

PValue Bonferroni FDR "-logP"1.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.79929

1.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.799291.59E-71 4.57E-69 4.57E-69 70.79929

Metabolism Count %Pyrimidine metabolism 18 26.9Purine metabolism 19 28.4DNA replication 9 13.4Cysteine and methionine metabolism 5 7.5Base excision repair 5 7.5Nucleotide excision repair 5 7.5Arginine and proline metabolism 5 7.5Glycine, serine and threonine metabolism 4 6Pantothenate and CoA biosynthesis 3 4.5Drug metabolism 4 6One carbon pool by folate 3 4.5beta-Alanine metabolism 3 4.5Nitrogen metabolism 3 4.5Pentose phosphate pathway 3 4.5Selenoamino acid metabolism 3 4.5Ubiquinone and other terpenoid-quinone biosyn 2 3

P-Value Benjamini "-logP"8.20E-16 6.10E-14 15.086192.20E-13 8.80E-12 12.657581.00E-08 2.80E-07 88.50E-04 1.70E-02 3.0705819.50E-04 1.50E-02 3.0222762.20E-03 2.90E-02 2.6575774.50E-03 4.90E-02 2.3467876.90E-03 6.60E-02 2.1611511.50E-02 1.30E-01 1.8239091.70E-02 1.30E-01 1.7695511.70E-02 1.20E-01 1.7695513.20E-02 1.90E-01 1.494853.40E-02 1.90E-01 1.4685214.00E-02 2.10E-01 1.397944.30E-02 2.10E-01 1.3665328.60E-02 3.60E-01 1.065502