Item Name Plate Number Plate LocationABT-263 (Navitoclax) 1 a1

ABT-737 1 a2

Linifanib (ABT-869) 1 a3

ABT-888 (Veliparib) 1 a4

Axitinib 1 a5

Saracatinib (AZD0530) 1 a6

FG-4592 1 a7

AZD6244 (Selumetinib) 1 a8

BEZ235 (NVP-BEZ235) 1 a9

BIBF1120 (Vargatef) 1 a10

Afatinib (BIBW2992) 1 a11

Bortezomib (Velcade) 1 b1

Bosutinib (SKI-606) 1 b2

Cediranib (AZD2171) 1 b3

Dovitinib (TKI-258) 1 b4

CI-1033 (Canertinib) 1 b5

CI-1040 (PD184352) 1 b6

Dasatinib (BMS-354825) 1 b7

Deforolimus (Ridaforolimus) 1 b8

Erlotinib HCl 1 b9

Gefitinib (Iressa) 1 b10

Imatinib Mesylate 1 b11

Lapatinib Ditosylate (Tykerb) 1 c1

Lenalidomide (Revlimid) 1 c2

Motesanib Diphosphate (AMG-706) 1 c3

Nilotinib (AMN-107) 1 c4

NVP-AEW541 1 c5

Pazopanib HCl 1 c6

PD0325901 1 c7

PI-103 1 c8

Rapamycin (Sirolimus) 1 c9

Sorafenib (Nexavar) 1 c10

STF-62247 1 c11

Sunitinib Malate (Sutent) 1 d1

Tandutinib (MLN518) 1 d2

Temsirolimus (Torisel) 1 d3

Trichostatin A (TSA) 1 d4

Vandetanib (Zactima) 1 d5

Vorinostat (SAHA) 1 d6

VX-680 (MK-0457, Tozasertib) 1 d7

Y-27632 2HCl 1 d8

Elesclomol 1 d9

Entinostat (MS-275, SNDX-275) 1 d10

Enzastaurin (LY317615) 1 d11

BMS-599626 (AC480) 1 e1

Obatoclax mesylate (GX15-070) 1 e2

Olaparib (AZD2281) 1 e3

Nutlin-3 1 e4

Masitinib (AB1010) 1 e5

GDC-0941 1 e6

SL327 1 e7

SB 431542 1 e8

Crizotinib (PF-02341066) 1 e9

AUY922 (NVP-AUY922) 1 e10

PHA-665752 1 e11

HA14-1 1 f1

ZSTK474 1 f2

SB 216763 1 f3

SB 203580 1 f4

SB 202190 1 f5

MK-2206 2HCl 1 f6

PD153035 HCl 1 f7

SU11274 1 f8

Vismodegib (GDC-0449) 1 f9

Brivanib (BMS-540215) 1 f10

Belinostat (PXD101) 1 f11

Iniparib (BSI-201) 1 g1

NVP-ADW742 1 g2

PCI-24781 1 g3

Linsitinib (OSI-906) 1 g4

KU-55933 1 g5

GSK1904529A 1 g6

PF-04217903 1 g7

LAQ824 (NVP-LAQ824, Dacinostat) 1 g8

JNJ-26481585 1 g9

BTZ043 racemate 1 g10

Rucaparib (AG-014699 , PF-01367338) 1 g11

MLN8054 1 h1

Vatalanib 2HCl (PTK787) 1 h2

U0126-EtOH 1 h3

ZM-447439 1 h4

GDC-0879 1 h5

LY294002 1 h6

OSU-03012 (AR-12) 1 h7

Danusertib (PHA-739358) 1 h8

TAE684 (NVP-TAE684) 1 h9

BI 2536 1 h10

Varespladib (LY315920) 1 h11

Foretinib (GSK1363089, XL880) 2 a1

SGX-523 2 a2

GSK690693 2 a3

JNJ-38877605 2 a4

Odanacatib (MK 0822) 2 a5

PD 0332991 (Palbociclib) HCl 2 a6

Triciribine (Triciribine phosphate) 2 a7

XL147 2 a8

XL-184 (Cabozantinib) 2 a9

Everolimus (RAD001) 2 a10

TW-37 2 a11

Mocetinostat (MGCD0103) 2 b1

Abiraterone (CB-7598) 2 b2

SRT1720 2 b3

YM155 2 b4

INO-1001 2 b5

MLN8237 (Alisertib) 2 b6

AT9283 2 b7

Pemetrexed (Alimta) 2 b8

Brivanib alaninate (BMS-582664) 2 b9

ADL5859 HCl 2 b10

Andarine (GTX-007) 2 b11

17-AAG (Tanespimycin) 2 c1

17-DMAG HCl (Alvespimycin) 2 c2

AG-490 2 c3

Ivacaftor (VX-770) 2 c4

SNS-032 (BMS-387032) 2 c5

Cyclopamine 2 c6

Barasertib (AZD1152-HQPA) 2 c7

Docetaxel (Taxotere) 2 c8

Gemcitabine HCl (Gemzar) 2 c9

Paclitaxel (Taxol) 2 c10

PLX-4720 2 c11

Roscovitine (Seliciclib, CYC202) 2 d1

SNS-314 Mesylate 2 d2

NSC 74859 (S3I-201) 2 d3

Capecitabine (Xeloda) 2 d4

MK-8245 2 d5

Ganetespib (STA-9090) 2 d6

TRAM-34 2 d7

AT13387 2 d8

E7080 (Lenvatinib) 2 d9

ABT-751 2 d10

Cisplatin 2 d11

CP-724714 2 e1

Valproic acid sodium salt (Sodium val 2 e2

TGX-221 2 e3

WZ3146 2 e4

CYC116 2 e5

JNJ 26854165 (Serdemetan) 2 e6

WZ4002 2 e7

Ostarine (MK-2866) 2 e8

BIIB021 2 e9

PD98059 2 e10

Regorafenib (BAY 73-4506) 2 e11

WZ8040 2 f1

XAV-939 2 f2

ENMD-2076 2 f3

Danoprevir 2 f4

Ritonavir 2 f5

BIBR 1532 2 f6

PIK-90 2 f7

Anastrozole 2 f8

Aprepitant (MK-0869) 2 f9

Bicalutamide (Casodex) 2 f10

Fulvestrant (Faslodex) 2 f11

Raltitrexed (Tomudex) 2 g1

Thalidomide 2 g2

CUDC-101 2 g3

TAK-700 (Orteronel) 2 g4

Exemestane 2 g5

Finasteride 2 g6

Irinotecan 2 g7

Cladribine 2 g8

Decitabine 2 g9

Dimesna 2 g10

Dutasteride 2 g11

PIK-75 2 h1

Bisoprolol 2 h2

Tivozanib (AV-951) 2 h3

Doxorubicin (Adriamycin) 2 h4

Adrucil (Fluorouracil) 2 h5

Abitrexate (Methotrexate) 2 h6

Bendamustine HCL 2 h7

Nelarabine (Arranon) 2 h8

Bleomycin sulfate 2 h9

Carboplatin 2 h10

PFI-1 2 h11

Clafen (Cyclophosphamide) 3 a1

Clofarabine 3 a2

YM201636 3 a3

OSI-930 3 a4

Dacarbazine (DTIC-Dome) 3 a5

Epirubicin HCl 3 a6

Oxaliplatin (Eloxatin) 3 a7

Etoposide (VP-16) 3 a8

Ku-0063794 3 a9

Evista (Raloxifene HCl) 3 a10

Idarubicin HCl 3 a11

Fludarabine Phosphate (Fludara) 3 b1

Topotecan HCl 3 b2

2-Methoxyestradiol 3 b3

AG-1024 3 b4

Letrozole 3 b5

Temozolomide 3 b6

Vincristine 3 b7

Agomelatine 3 b8

Amuvatinib (MP-470) 3 b9

Vinblastine 3 b10

JNJ-7706621 3 b11

MDV3100 (Enzalutamide) 3 c1

Dienogest 3 c2

Rufinamide (Banzel) 3 c3

Posaconazole 3 c4

Prasugrel (Effient) 3 c5

Ramelteon (TAK-375) 3 c6

AMG-073 HCl (Cinacalcet HCl) 3 c7

Celecoxib 3 c8

BMS-708163 (Avagacestat) 3 c9

PD173074 3 c10

WYE-354 3 c11

Vemurafenib (PLX4032) 3 d1

IC-87114 3 d2

BX-795 3 d3

BX-912 3 d4

Amisulpride 3 d5

Aniracetam 3 d6

Asenapine 3 d7

Benazepril HCl 3 d8

Biperiden HCl 3 d9

Camptothecin 3 d10

Carmofur 3 d11

Celastrol 3 e1

Cetirizine DiHCl 3 e2

Cilnidipine 3 e3

Cilostazol 3 e4

Epothilone A 3 e5

Floxuridine (Fludara) 3 e6

Ftorafur 3 e7

Ifosfamide 3 e8

Megestrol Acetate 3 e9

Mercaptopurine 3 e10

Zoledronic Acid (Zoledronate) 3 e11

Ki16425 3 f1

AMG-208 3 f2

Costunolide 3 f3

Dexamethasone 3 f4

Doxazosin mesylate 3 f5

Ellagic acid 3 f6

Etodolac (Lodine) 3 f7

Etomidate 3 f8

Flumazenil 3 f9

Fluoxetine HCl 3 f10

Flupirtine maleate 3 f11

Fluvoxamine maleate 3 g1

Gabapentin HCl 3 g2

Galanthamine HBr 3 g3

Genistein 3 g4

Glimepiride 3 g5

Granisetron HCl 3 g6

TG100-115 3 g7

Ketoconazole 3 g8

Lansoprazole 3 g9

Lidocaine (Alphacaine) 3 g10

Loratadine 3 g11

Losartan potassium 3 h1

GSK1059615 3 h2

MGCD-265 3 h3

Rigosertib (ON-01910) 3 h4

Ki8751 3 h5

Epothilone B (EPO906) 3 h6

BMS-707035 3 h7

Amonafide 3 h8

Dorzolamide HCl 3 h9

Gestodene 3 h10

Drospirenone 3 h11

Ruxolitinib (INCB018424) 4 a1

Isotretinoin 4 a2

Lopinavir (ABT-378) 4 a3

Mianserin HCl 4 a4

Minoxidil 4 a5

Mizoribine (Bredinin) 4 a6

Mosapride citrate 4 a7

Nafamostat mesylate 4 a8

Naftopidil DiHCl 4 a9

Omeprazole (Prilosec) 4 a10

Ondansetron HCl (Zofran) 4 a11

Oxcarbazepine 4 b1

Pelitinib (EKB-569) 4 b2

Resveratrol 4 b3

Rocuronium bromide 4 b4

Stavudine 4 b5

Tenofovir Disoproxil Fumarate 4 b6

Tenofovir (Viread) 4 b7

Trilostane 4 b8

Alfuzosin HCl (Uroxatral) 4 b9

AS-605240 4 b10

Clopidogrel (Plavix) 4 b11

Staurosporine 4 c1

Droxinostat 4 c2

Ranolazine 2HCl 4 c3

Repaglinide 4 c4

Rolipram 4 c5

Sildenafil citrate 4 c6

Sumatriptan succinate 4 c7

Tianeptine sodium 4 c8

Tizanidine HCl 4 c9

Topiramate 4 c10

Varenicline tartrate 4 c11

Venlafaxine 4 d1

Voriconazole 4 d2

Zileuton 4 d3

Aurora A Inhibitor I 4 d4

Ispinesib (SB-715992) 4 d5

Tipifarnib (Zarnestra) 4 d6

PHA-680632 4 d7

Cilomilast (SB-207499) 4 d8

Zibotentan (ZD4054) 4 d9

Atazanavir sulfate 4 d10

Thiazovivin 4 d11

SP600125 4 e1

Ofloxacin (Floxin) 4 e2

Moxifloxacin HCl 4 e3

Alfacalcidol 4 e4

TSU-68 (SU6668) 4 e5

Safinamide Mesylate (FCE28073) 4 e6

GSK429286A 4 e7

AS703026 (pimasertib) 4 e8

SB 525334 4 e9

Oligomycin A 4 e10

VX-222 4 e11

LY335979 (Zosuquidar 3HCl) 4 f1

4 f2

MC1568 4 f3

HMN-214 4 f4

AEE788 (NVP-AEE788) 4 f5

PHA-793887 4 f6

Naratriptan HCl 4 f7

PIK-93 4 f8

Ponatinib (AP24534) 4 f9

Fludarabine (Fludara) 4 f10

LY2228820 4 f11

Pralatrexate (Folotyn) 4 g1

NVP-BEP800 4 g2

Mycophenolate mofetil (CellCept) 4 g3

Dyphylline (Dilor) 4 g4

Perindopril Erbumine (Aceon) 4 g5

Irbesartan (Avapro) 4 g6

Tadalafil (Cialis) 4 g7

SB939 (Pracinostat) 4 g8

Ibuprofen Lysine (NeoProfen) 4 g9

CCT129202 4 g10

Tosedostat (CHR2797) 4 g11

XL765 (SAR245409) 4 h1

AT7519 4 h2

MK-1775 4 h3

Quizartinib (AC220) 4 h4

LY2811376 4 h5

Hesperadin 4 h6

BIX 02188 4 h7

BIX 02189 4 h8

Daclatasvir （BMS-790052）

AZD7762 4 h9

R406 (free base) 4 h10

CP 673451 4 h11

DMXAA (ASA404) 5 a1

Telaprevir (VX-950) 5 a2

Saxagliptin (BMS-477118,Onglyza) 5 a3

EX 527 5 a4

AM-1241 5 a5

SB-408124 5 a6

Dapagliflozin 5 a7

Nebivolol (Bystolic) 5 a8

Pimobendan (Vetmedin) 5 a9

AZD8055 5 a10

PHT-427 5 a11

KRN 633 5 b1

AT7867 5 b2

BMS 777607 5 b3

VX-809 5 b4

Pomalidomide 5 b5

PD318088 5 b6

KU-60019 5 b7

BS-181 HCl 5 b8

Fasudil HCl (HA-1077) 5 b9

BIRB 796 (Doramapimod) 5 b10

Tie2 kinase inhibitor 5 b11

Candesartan (Atacand) 5 c1

PD 0332991 (Palbociclib) Isethionate 5 c2

H 89 2HCl 5 c3

TWS119 5 c4

Ubenimex (Bestatin) 5 c5

Apixaban 5 c6

Semagacestat (LY450139) 5 c7

Olmesartan medoxomil (Benicar) 5 c8

Rizatriptan Benzoate (Maxalt) 5 c9

Pyridostigmine Bromide (Mestinon) 5 c10

Cefoperazone (Cefobid) 5 c11

Silodosin (Rapaflo) 5 d1

Riluzole (Rilutek) 5 d2

Risperidone (Risperdal) 5 d3

Acetylcysteine 5 d4

Alendronate (Fosamax) 5 d5

Naproxen (Aleve) 5 d6

Nitazoxanide (Alinia, Annita) 5 d7

Orlistat (Alli, Xenical) 5 d8

Allopurinol (Zyloprim) 5 d9

Allopurinol Sodium (Aloprim) 5 d10

Zafirlukast (Accolate) 5 d11

Ibuprofen (Advil) 5 e1

Amprenavir (Agenerase) 5 e2

Methyldopa (Aldomet) 5 e3

Ketoprofen (Actron) 5 e4

Ketorolac (Toradol) 5 e5

Cytarabine 5 e6

Zolmitriptan (Zomig) 5 e7

Enalaprilat dihydrate 5 e8

Isradipine (Dynacirc) 5 e9

Estrone 5 e10

Flucytosine (Ancobon) 5 e11

Aminoglutethimide (Cytadren) 5 f1

Aminophylline (Truphylline) 5 f2

Carbamazepine (Carbatrol) 5 f3

Torsemide (Demadex) 5 f4

Didanosine (Videx) 5 f5

Divalproex sodium 5 f6

Emtricitabine (Emtriva) 5 f7

Lamivudine (Epivir) 5 f8

Eplerenone 5 f9

Piroxicam (Feldene) 5 f10

Gemcitabine (Gemzar) 5 f11

Adefovir Dipivoxil (Preveon, Hepsera) 5 g1

Zalcitabine 5 g2

Paliperidone (Invega) 5 g3

Telmisartan (Micardis) 5 g4

Nevirapine (Viramune) 5 g5

Esomeprazole magnesium (Nexium) 5 g6

Nimodipine (Nimotop) 5 g7

Nisoldipine (Sular) 5 g8

Oxybutynin (Ditropan) 5 g9

Quetiapine fumarate (Seroquel) 5 g10

Chlorprothixene 5 g11

Thioguanine 5 h1

Toremifene Citrate (Fareston, Acapod 5 h2

Azacitidine (Vidaza) 5 h3

Bacitracin zinc 5 h4

Simvastatin (Zocor) 5 h5

Ramipril (Altace) 5 h6

Ranitidine (Zantac) 5 h7

Acadesine 5 h8

Acetylcholine chloride 5 h9

Nifedipine (Adalat) 5 h10

Amlodipine besylate (Norvasc) 5 h11

Chlorpheniramine Maleate 6 a1

Betaxolol HCl (Betoptic) 6 a2

Proparacaine HCl 6 a3

Pranlukast 6 a4

Carvedilol 6 a5

Butoconazole nitrate 6 a6

Azithromycin (Zithromax) 6 a7

Flubendazole (Flutelmium) 6 a8

Lomustine (CeeNU) 6 a9

Cimetidine (Tagamet) 6 a10

Clemastine Fumarate 6 a11

Bifonazole 6 b1

Metoprolol tartrate 6 b2

Etidronate (Didronel) 6 b3

Dapoxetine HCl (Priligy) 6 b4

Tranexamic acid (Transamin) 6 b5

Roxatidine acetate HCl 6 b6

Felodipine (Plendil) 6 b7

Nizatidine 6 b8

Carbidopa 6 b9

Valsartan (Diovan) 6 b10

Tropisetron 6 b11

Diclofenac sodium 6 c1

Amlodipine (Norvasc) 6 c2

Flutamide (Eulexin) 6 c3

Fluvastatin sodium (Lescol) 6 c4

Tropicamide 6 c5

Pregnenolone 6 c6

Sulfamethoxazole 6 c7

Irsogladine 6 c8

Enalapril maleate (Vasotec) 6 c9

Metformin HCl (Glucophage) 6 c10

Tolfenamic acid 6 c11

Pranoprofen 6 d1

Nefiracetam (Translon) 6 d2

Nicorandil (Ikorel) 6 d3

Tamoxifen Citrate (Nolvadex) 6 d4

Meglumine 6 d5

Aripiprazole (Abilify) 6 d6

Methscopolamine (Pamine) 6 d7

Amiodarone HCl 6 d8

Adenine 6 d9

Adenine sulfate 6 d10

Adenine HCl 6 d11

Ticlopidine HCl 6 e1

Lacidipine (Lacipil, Motens) 6 e2

Procarbazine HCl (Matulane) 6 e3

Ondansetron (Zofran) 6 e4

Sodium orthovanadate 6 e5

Elvitegravir (GS-9137) 6 e6

Maraviroc 6 e7

Raltegravir (MK-0518) 6 e8

Pyrimethamine 6 e9

Pramipexole 2HCl monohydrate 6 e10

PCI-34051 6 e11

PF 573228 6 f1

BMS-265246 6 f2

Suplatast tosylate 6 f3

ENMD-2076 L-(+)-Tartaric acid 6 f4

Formoterol hemifumarate 6 f5

Ketotifen fumarate (Zaditor) 6 f6

Urapidil HCl 6 f7

Ginkgolide A 6 f8

Uridine 6 f9

Flunarizine 2HCl 6 f10

Rebamipide 6 f11

Epalrestat 6 g1

Candesartan cilexetil (Atacand) 6 g2

Phentolamine mesilate 6 g3

Nimesulide 6 g4

Cyproterone acetate 6 g5

Memantine HCl (Namenda) 6 g6

Cyproheptadine HCl (Periactin) 6 g7

Doxifluridine 6 g8

Pioglitazone HCl (Actos) 6 g9

Lornoxicam (Xefo) 6 g10

Strontium ranelate (Protelos) 6 g11

Captopril (Capoten) 6 h1

Orphenadrine citrate (Norflex) 6 h2

Gimeracil 6 h3

Terazosin HCl (Hytrin) 6 h4

Lovastatin (Mevacor) 6 h5

Lafutidine 6 h6

Moxonidine 6 h7

Ozagrel HCl 6 h8

Mitiglinide calcium 6 h9

Rosiglitazone HCl 6 h10

Lisinopril (Zestril) 6 h11

Atorvastatin calcium (Lipitor) 7 a1

Famotidine (Pepcid) 7 a2

Moexipril HCl 7 a3

Cleviprex (Clevidipine) 7 a4

Cilazapril monohydrate (Inhibace) 7 a5

Adiphenine HCl 7 a6

Duloxetine HCl (Cymbalta) 7 a7

Trimebutine 7 a8

Ivabradine HCl (Procoralan) 7 a9

Rivastigmine tartrate (Exelon) 7 a10

Dexmedetomidine HCl (Precedex) 7 a11

Betaxolol (Betoptic) 7 b1

Detomidine HCl 7 b2

Fosinopril sodium (Monopril) 7 b3

Almotriptan malate (Axert) 7 b4

Ambrisentan 7 b5

Bexarotene 7 b6

Temocapril HCl 7 b7

Gabexate mesylate 7 b8

Rasagiline mesylate 7 b9

Naltrexone HCl 7 b10

Levosulpiride (Levogastrol) 7 b11

Azasetron HCl (Y-25130) 7 c1

Mizolastine (Mizollen) 7 c2

Flunixin meglumin 7 c3

Vinpocetine (Cavinton) 7 c4

Lapatinib 7 c5

Blonanserin (Lonasen) 7 c6

Cisatracurium besylate (Nimbex) 7 c7

Ibutilide fumarate 7 c8

Naftopidil (Flivas) 7 c9

S- (+)-Rolipram 7 c10

Bazedoxifene HCl 7 c11

Atropine 7 d1

Roflumilast (Daxas) 7 d2

Gabapentin (Neurontin) 7 d3

AZD8330 7 d4

GSK1292263 7 d5

Neratinib (HKI-272) 7 d6

LDE225 (NVP-LDE225, Erismodegib) 7 d7

CGS 21680 HCl 7 d8

BIBR-1048 (Dabigatran etexilate, Prad 7 d9

LY2608204 7 d10

LY2886721 7 d11

LY2940680 7 e1

KW 2449 7 e2

Tebipenem pivoxil (L-084) 7 e3

PF-4708671 7 e4

PD 128907 HCl 7 e5

Rosuvastatin calcium (Crestor) 7 e6

ITF2357 (Givinostat) 7 e7

AG14361 7 e8

LY2784544 7 e9

MLN2238 7 e10

MLN9708 7 e11

SB 743921 7 f1

BGJ398 (NVP-BGJ398) 7 f2

AST-1306 7 f3

SB-505124 7 f4

Avasimibe (CI-1011) 7 f5

AZD8931 7 f6

GSK461364 7 f7

R406 7 f8

SGI-1776 free base 7 f9

Aliskiren hemifumarate 7 f10

BMS 794833 7 f11

NVP-BHG712 7 g1

OSI-420 7 g2

R935788 (Fostamatinib disodium, R78 7 g3

PIK-293 7 g4

Formestane 7 g5

Vinflunine Tartrate 7 g6

AZ 960 7 g7

DAPT (GSI-IX) 7 g8

Mubritinib (TAK 165) 7 g9

Irinotecan HCl Trihydrate (Campto) 7 g10

PP242 7 g11

Cyt387 7 h1

SB590885 7 h2

Apatinib (YN968D1) 7 h3

TAME 7 h4

CAL-101 (GS-1101) 7 h5

PIK-294 7 h6

Eltrombopag (SB-497115-GR) 7 h7

LY2157299 7 h8

Telatinib (BAY 57-9352) 7 h9

Ketanserin (Vulketan Gel) 7 h10

Esomeprazole sodium (Nexium) 7 h11

BI6727 (Volasertib) 8 a1

Palomid 529 8 a2

Fesoterodine fumarate (Toviaz) 8 a3

WP1130 8 a4

AR-42 (HDAC-42) 8 a5

CP-466722 8 a6

Abiraterone Acetate (CB7630) 8 a7

BKM120 (NVP-BKM120) 8 a8

CX-4945 (Silmitasertib) 8 a9

(-)-Huperzine A 8 a10

4-Methylumbelliferone (4-MU) 8 a11

Aloe-emodin 8 b1

Apigenin 8 b2

Arbutin (Uva, p-Arbutin) 8 b3

Artesunate 8 b4

Asiatic acid 8 b5

Baicalein 8 b6

Baicalin 8 b7

Cryptotanshinone 8 b8

Cytisine (Baphitoxine, Sophorine) 8 b9

Hesperetin 8 b10

Honokiol 8 b11

Icariin 8 c1

Luteolin 8 c2

Matrine ((+)-Matrine) 8 c3

Neohesperidin 8 c4

Parthenolide ((-)-Parthenolide) 8 c5

Puerarin (Kakonein) 8 c6

Salinomycin (Procoxacin) 8 c7

Synephrine (Oxedrine) 8 c8

5-hydroxytryptophan (5-HTP) 8 c9

Aloin (Barbaloin) 8 c10

Dioscin (Collettiside III) 8 c11

Indirubin 8 d1

Quercetin (Sophoretin) 8 d2

Naringenin 8 d3

Salidroside (Rhodioloside) 8 d4

Sodium Danshensu 8 d5

Tetrandrine (Fanchinine) 8 d6

Chrysophanic acid (Chrysophanol) 8 d7

Astragaloside A 8 d8

20-Hydroxyecdysone 8 d9

10-Hydroxycamptothecin 8 d10

Apocynin (Acetovanillone) 8 d11

Rotundine 8 e1

Synephrine HCl 8 e2

Tolbutamide 8 e3

Forskolin 8 e4

Equol 8 e5

Amantadine HCl (Symmetrel) 8 e6

Amfebutamone (Bupropion) 8 e7

Benserazide 8 e8

Bupivacaine HCl (Marcain) 8 e9

Bethanechol chloride 8 e10

Chlorpromazine (Sonazine) 8 e11

Clonidine HCl (Catapres) 8 f1

Clozapine (Clozaril) 8 f2

Pramipexole (Mirapex) 8 f3

Domperidone (Motilium) 8 f4

Donepezil HCl (Aricept) 8 f5

Estriol 8 f6

Fluocinolone acetonide (Flucort-N) 8 f7

Gallamine triethiodide (Flaxedil) 8 f8

Hexestrol (Bibenzyl) 8 f9

Imatinib (Gleevec) 8 f10

Loperamide HCl 8 f11

Manidipine (Manyper) 8 g1

Manidipine 2HCl (CV-4093) 8 g2

Milrinone (Primacor) 8 g3

Mitoxantrone HCl 8 g4

Nateglinide (Starlix) 8 g5

Neostigmine bromide (Prostigmin) 8 g6

Nitrendipine 8 g7

Olanzapine (Zyprexa) 8 g8

Olopatadine HCl (Opatanol) 8 g9

Oxymetazoline HCl 8 g10

Ozagrel 8 g11

Pancuronium (Pavulon) 8 h1

Phenoxybenzamine HCl 8 h2

Propafenone (Rytmonorm) HCl 8 h3

Racecadotril (Acetorphan) 8 h4

Rosiglitazone maleate 8 h5

Salbutamol sulfate (Albuterol) 8 h6

Scopolamine HBr 8 h7

Sotalol (Betapace) 8 h8

Sulfadoxine (Sulphadoxine) 8 h9

Tenoxicam (Mobiflex) 8 h10

Vardenafil Hydrochloride Trihydrate ( 8 h11

Xylazine HCl 9 a1

Maprotiline HCl 9 a2

Naphazoline HCl (Naphcon) 9 a3

Epinephrine bitartrate (Adrenalinium) 9 a4

L-Adrenaline (Epinephrine) 9 a5

DL-Adrenaline 9 a6

Phenytoin sodium (Dilantin) 9 a7

Phenytoin (Lepitoin) 9 a8

Alizarin 9 a9

Dopamine HCl (Inotropin) 9 a10

Asaraldehyde (Asaronaldehyde) 9 a11

Ritodrine HCl (Yutopar) 9 b1

Clomipramine HCl (Anafranil) 9 b2

Phenformin HCl 9 b3

Scopine 9 b4

Tiotropium Bromide hydrate 9 b5

Scopine HCl 9 b6

Trospium chloride (Sanctura) 9 b7

Tolterodine tartrate (Detrol LA) 9 b8

Azelastine HCl (Astelin) 9 b9

Daphnetin 9 b10

Clarithromycin (Biaxin, Klacid) 9 b11

Rosiglitazone (Avandia) 9 c1

Amiloride HCl dihydrate 9 c2

Clomifene citrate (Serophene) 9 c3

Hydralazine HCl 9 c4

Isoprenaline HCl 9 c5

Medroxyprogesterone acetate 9 c6

Phenylephrine HCl 9 c7

Tetracaine HCl (Pontocaine) 9 c8

Phenacetin 9 c9

Zidovudine (Retrovir) 9 c10

Quinapril HCl (Accupril) 9 c11

Trazodone HCl (Desyrel) 9 d1

Brompheniramine 9 d2

Pioglitazone (Actos) 9 d3

Tolvaptan (OPC-41061) 9 d4

Gliclazide (Diamicron) 9 d5

Acemetacin (Emflex) 9 d6

Tioxolone 9 d7

Dehydroepiandrosterone (DHEA) 9 d8

Mifepristone (Mifeprex) 9 d9

Lonidamine 9 d10

Ethisterone 9 d11

Arecoline 9 e1

Noradrenaline bitartrate monohydrate 9 e2

TAK-733 9 e3

LDN193189 9 e4

GSK256066 9 e5

AZD5438 9 e6

PP-121 9 e7

OSI-027 9 e8

R788 (Fostamatinib) 9 e9

LY2603618 (IC-83) 9 e10

Tubastatin A HCl 9 e11

PF-05212384 (PKI-587) 9 f1

PNU-120596 9 f2

GW3965 HCl 9 f3

URB597 9 f4

BMS-806 (BMS 378806) 9 f5

DCC-2036 (Rebastinib) 9 f6

CCT128930 9 f7

A66 9 f8

TAK-875 9 f9

NU7441 (KU-57788) 9 f10

SNX-2112 9 f11

PF-04929113 (SNX-5422) 9 g1

GSK2126458 9 g2

5-hydroxymethyl tolterodine (PNU 200 9 g3

MK-0752 9 g4

WYE-125132 9 g5

WAY-100635 HCl 9 g6

Clinofibrate 9 g7

Ciprofibrate 9 g8

PF-3845 9 g9

S/GSK1349572 (GSK1349572) 9 g10

WYE-687 9 g11

LY310762 9 h1

A-674563 9 h2

AS-252424 9 h3

PF-00562271 9 h4

GSK1120212 (Trametinib) 9 h5

A 922500 9 h6

BRL-15572 9 h7

NSC-207895 (XI-006) 9 h8

Flavopiridol (Alvocidib) HCl 9 h9

PCI-32765 (Ibrutinib) 9 h10

AS-604850 9 h11

CAY10505 10 a1

CHIR-124 10 a2

CX-5461 10 a3

KW-2478 10 a4

NVP-BSK805 2HCl 10 a5

R547 10 a6

WAY-600 10 a7

ADX-47273 10 a8

BMY 7378 10 a9

TG101209 10 a10

WAY-362450 10 a11

GDC-0980 (RG7422) 10 b1

A-769662 10 b2

RS-127445 10 b3

CH5132799 10 b4

KX2-391 10 b5

GSK1838705A 10 b6

LY2109761 10 b7

YO-01027 10 b8

Geldanamycin 10 b9

LY411575 10 b10

CP-91149 10 b11

TAK-901 10 c1

AMG 900 10 c2

ZM 336372 10 c3

Nilvadipine (ARC029) 10 c4

JTC-801 10 c5

PF-03814735 10 c6

PH-797804 10 c7

Dacomitinib (PF299804,PF-00299804) 10 c8

AG-1478 (Tyrphostin AG-1478) 10 c9

SB 415286 10 c10

Crenolanib (CP-868596) 10 c11

AZ 3146 10 d1

TG101348 (SAR302503) 10 d2

PAC-1 10 d3

PKI-402 10 d4

GSK1070916 10 d5

PHA-767491 10 d6

PF-04691502 10 d7

CCT137690 10 d8

CHIR-98014 10 d9

AZ628 10 d10

AMG458 10 d11

Anacetrapib (MK-0859) 10 e1

NVP-BGT226 10 e2

GW788388 10 e3

Milciclib (PHA-848125) 10 e4

Arry-380 10 e5

AT-406 10 e6

ARRY334543 10 e7

Wortmannin 10 e8

PI3K/HDAC Inhibitor I 10 e9

Canagliflozin 10 e10

NVP-BVU972 10 e11

CH5424802 10 f1

MK-2048 10 f2

3-Methyladenine 10 f3

Dinaciclib (SCH727965) 10 f4

Dovitinib Dilactic acid (TKI258 Dilactic 10 f5

MK-5108 (VX-689) 10 f6

Dalcetrapib (JTT-705) 10 f7

SB705498 10 f8

MK-2461 10 f9

Nocodazole 10 f10

CPI-613 10 f11

PF-5274857 10 g1

GW842166X 10 g2

M344 10 g3

RITA (NSC 652287) 10 g4

GW4064 10 g5

AZD2014 10 g6

TAK-285 10 g7

A-803467 10 g8

INCB28060 10 g9

Tofacitinib (CP-690550, Tasocitinib) 10 g10

Istradefylline (KW-6002) 10 g11

Sotrastaurin (AEB071) 10 h1

Torcetrapib (CP-529414) 10 h2

VU 0357121 10 h3

WP1066 10 h4

Lonafarnib (SCH66336) 10 h5

APO866 (FK866) 10 h6

AZD4547 10 h7

BAY80-6946 10 h8

Galeterone (TOK-001) 10 h9

Sirtinol 10 h10

LY364947 10 h11

CEP33779 11 a1

Dabrafenib (GSK2118436) 11 a2

GDC-0068 11 a3

MPEP 11 a4

INK 128 (MLN0128) 11 a5

AT101 11 a6

Ciproxifan 11 a7

BYL719 11 a8

Tyrphostin AG 879 (AG 879) 11 a9

Torin 2 11 a10

CI994 (Tacedinaline) 11 a11

AM251 11 b1

NVP-TAE226 11 b2

RG108 11 b3

Tideglusib 11 b4

TPCA-1 11 b5

ML133 HCl 11 b6

Desmethyl Erlotinib (CP-473420) 11 b7

Torin 1 11 b8

JNJ 1661010 11 b9

Epiandrosterone (3β-androsterone) 11 b10

ARN-509 11 b11

SAR131675 11 c1

BI-D1870 11 c2

Semaxanib (SU5416) 11 c3

Cathepsin Inhibitor 1 11 c4

SB-269970 HCl 11 c5

Baricitinib (LY3009104, INCB28050) 11 c6

BRL 54443 11 c7

Carfilzomib (PR-171) 11 c8

BML-190 11 c9

MRS 2578 11 c10

SB 271046 11 c11

Dizocilpine (MK 801) 11 d1

StemRegenin 1 11 d2

Golvatinib (E7050) 11 d3

IEM 1754 dihydrobroMide 11 d4

CTEP 11 d5

VU 0364770 11 d6

ML130 11 d7

IMD 0354 11 d8

VUF 10166 11 d9

U-104 11 d10

WHI-P154 11 d11

Alogliptin (SYR-322) 11 e1

TG 100713 11 e2

T0070907 11 e3

GW5074 11 e4

Camostat Mesilate (FOY-305) 11 e5

Prucalopride 11 e6

(-)-MK 801 Maleate 11 e7

L-NAME HCl 11 e8

IKK-16 11 e9

A 205804 11 e10

PF-562271 11 e11

GW441756 11 f1

VU 0361737 11 f2

SB-742457 11 f3

Tyrphostin 9 (SF 6847) 11 f4

ZM 323881 HCl 11 f5

ZM 306416 11 f6

GNF-2 11 f7

Cobicistat (GS-9350) 11 f8

CCG 50014 11 f9

S-Ruxolitinib 11 f10

Lumiracoxib (COX-189) 11 f11

PF 477736 11 g1

JNJ-7777120 11 g2

Ki16198 11 g3

Pirfenidone 11 g4

Go 6983 11 g5

WZ 811 11 g6

BAY 11-7082 (BAY 11-7821) 11 g7

Dapivirine 11 g8

GW9662 11 g9

HC-030031 11 g10

IOX2 11 g11

Mozavaptan 11 h1

PF-4981517 11 h2

Icotinib 11 h3

Salubrinal 11 h4

CHIR-99021 (CT99021) HCl 11 h5

Evacetrapib (LY2484595) 11 h6

TDZD-8 11 h7

Apoptosis Activator 2 11 h8

TAK 715 11 h9

Pifithrin-α 11 h10

Rivaroxaban (Xarelto) 11 h11

Paroxetine HCl 12 a1

Zaltoprofen 12 a2

Pazopanib 12 a3

Plerixafor 8HCl (AMD3100 8HCl) 12 a4

Aspirin (Acetylsalicylic acid) 12 a5

Niflumic acid 12 a6

Ciclopirox ethanolamine 12 a7

Rimonabant (SR141716) 12 a8

Bufexamac 12 a9

Lamotrigine 12 a10

PMSF (Phenylmethylsulfonyl Fluoride) 12 a11

Piceatannol 12 b1

Niclosamide (Niclocide) 12 b2

Linagliptin (BI-1356) 12 b3

Bindarit 12 b4

Vildagliptin (LAF-237) 12 b5

Sitaxentan sodium (TBC-11251) 12 b6

Daunorubicin HCl (Daunomycin HCl) 12 b7

Pravastatin sodium 12 b8

Bepotastine Besilate 12 b9

Fosaprepitant dimeglumine 12 b10

Rofecoxib (Vioxx) 12 b11

Lurasidone HCl 12 c1

Azilsartan (TAK-536) 12 c2

Otilonium Bromide 12 c3

Solifenacin succinate 12 c4

Palonosetron HCl 12 c5

Bosentan Hydrate 12 c6

Rupatadine Fumarate 12 c7

Azelnidipine 12 c8

Miltefosine (Hexadecylphosphocholine 12 c9

Azilsartan Medoxomil (TAK-491) 12 c10

Medetomidine HCl 12 c11

Ambroxol HCl 12 d1

Amikacin sulfate 12 d2

Naloxone HCl 12 d3

Piracetam 12 d4

(R)-baclofen 12 d5

Dexmedetomidine 12 d6

Etravirine (TMC125) 12 d7

Ulipristal 12 d8

Indacaterol Maleate 12 d9

Oxybutynin chloride 12 d10

Milnacipran HCl 12 d11

Darifenacin HBr 12 e1

Tripelennamine HCl 12 e2

Entacapone 12 e3

Estradiol valerate 12 e4

Gliquidone 12 e5

Ethynodiol diacetate 12 e6

Benztropine mesylate 12 e7

Abacavir sulfate 12 e8

Altrenogest 12 e9

Anagrelide HCl 12 e10

Atomoxetine HCl 12 e11

Betahistine 2HCl 12 f1

Brinzolamide 12 f2

Flumequine 12 f3

Amitriptyline HCl 12 f4

Adrenalone HCl 12 f5

Azatadine dimaleate 12 f6

Ropinirole HCl 12 f7

Reboxetine mesylate 12 f8

Triflusal 12 f9

Trifluoperazine 2HCl 12 f10

Catharanthine 12 f11

Meptazinol HCl 12 g1

Fexofenadine HCl 12 g2

Moclobemide 12 g3

Betulinic acid 12 g4

Pergolide mesylate 12 g5

Cabozantinib malate 12 g6

Sitagliptin phosphate monohydrate 12 g7

Ethambutol HCl 12 g8

Doxycycline HCl 12 g9

Clinafloxacin (PD127391) 12 g10

Pentamidine HCl 12 g11

Pemirolast (BMY 26517) potassium 12 h1

Mirabegron (YM178) 12 h2

Acebutolol HCl 12 h3

Ampiroxicam 12 h4

Desloratadine 12 h5

Sodium Monofluorophosphate 12 h6

Hyoscyamine (Daturine) 12 h7

Ouabain 12 h8

Allylthiourea 12 h9

Avanafil 12 h10

Tolcapone 12 h11

Probenecid (Benemid) 13 a1

Procaine (Novocaine) HCl 13 a2

Homatropine Methylbromide 13 a3

Homatropine Bromide 13 a4

Hydroxyzine 2HCl 13 a5

Flavoxate HCl 13 a6

Dexamethasone Sodium Phosphate 13 a7

Aclidinium Bromide 13 a8

Bismuth Subsalicylate 13 a9

Diphemanil Methylsulfate 13 a10

Vitamin D2 (Ergocalciferol) 13 a11

Doxapram HCl 13 b1

Dibucaine (Cinchocaine) HCl 13 b2

Methazolamide 13 b3

Tetrahydrozoline HCl 13 b4

Valdecoxib 13 b5

Nabumetone 13 b6

Sertraline HCl 13 b7

Spironolactone 13 b8

Ropivacaine HCl 13 b9

Erythromycin Ethylsuccinate 13 b10

Vitamin D3 (Cholecalciferol) 13 b11

Escitalopram Oxalate 13 c1

Guanabenz (WY-8678) Acetate 13 c2

Dequalinium Chloride 13 c3

Hexamethonium Bromide 13 c4

Decamethonium Bromide 13 c5

Sodium 4-Aminosalicylate 13 c6

Sodium Nitrite 13 c7

Zinc Pyrithione 13 c8

Propranolol HCl 13 c9

Mefenamic Acid 13 c10

Ticagrelor 13 c11

Triamterene 13 d1

Sulfacetamide Sodium 13 d2

Lorcaserin HCl 13 d3

Estradiol Benzoate 13 d4

Desvenlafaxine Succinate 13 d5

Desvenlafaxine 13 d6

Histamine 2HCl 13 d7

Pefloxacin Mesylate Dihydrate 13 d8

Timolol Maleate 13 d9

Sodium Phenylbutyrate 13 d10

Terbutaline Sulfate 13 d11

Deoxyarbutin 13 e1

Tofacitinib citrate (CP-690550 citrate) 13 e2

Fingolimod (FTY720) 13 e3

LY2140023 (LY404039) 13 e4

PTC124 (Ataluren) 13 e5

VX-702 13 e6

PP2 13 e7

Stattic 13 e8

Embelin 13 e9

IPI-145 (INK1197) 13 e10

AZD2461 13 e11

PD168393 13 f1

Brefeldin A 13 f2

Oprozomib (ONX 0912) 13 f3

VX-661 13 f4

GSK J4 HCl 13 f5

(+)-Bicuculline 13 f6

NMDA (N-Methyl-D-aspartic acid) 13 f7

Cilengitide (EMD 121974, NSC 707544) 13 f8

KY02111 13 f9

(−)-Blebbistatin 13 f10

Zebularine 13 f11

AMG-517 13 g1

Tenovin-1 13 g2

Rocilinostat (ACY-1215) 13 g3

GSK2636771 13 g4

PQ 401 13 g5

ZM 39923 HCl 13 g6

SMI-4a 13 g7

BIX01294 13 g8

VE-821 13 g9

AG 18 (Tyrphostin 23) 13 g10

PRX-08066 13 g11

Otenabant (CP-945598) HCl 13 h1

GW9508 13 h2

CEP-32496 13 h3

TAK-438 13 h4

AZD5363 13 h5

GW0742 13 h6

Vortioxetine (Lu AA21004) hydrobrom 13 h7

Empagliflozin (BI10773) 13 h8

TCS 359 13 h9

Tyrphostin AG 1296 (AG 1296) 13 h10

GSK3787 13 h11

Tariquidar 14 a1

WY 14643 (Pirinixic Acid) 14 a2

Plerixafor (AMD3100) 14 a3

NSC 23766 14 a4

PRT062607 (P505-15, PRT2607, BIIB05 14 a5

Apremilast (CC-10004) 14 a6

VU 0364439 14 a7

Butein 14 a8

Necrostatin-1 14 a9

UPF 1069 14 a10

GDC-0349 14 b1

GW2580 14 b2

Scriptaid 14 b3

ABT-199 (GDC-0199 ) 14 b4

Macitentan 14 b5

CAS Number Concentration Molecular Weight Catalog Number923564-51-6 10 mM 974.61 S1001852808-04-9 10 mM 813.43 S1002

796967-16-3 10 mM 375.41 S1003912444-00-9 10 mM 244.29 S1004

319460-85-0 10 mM 386.47 S1005379231-04-6 10 mM 542.03 S1006

808118-40-3 10 mM 352.34 S1007606143-52-6 10 mM 457.68 S1008

915019-65-7 10 mM 469.55 S1009656247-17-5 10 mM 539.62 S1010

439081-18-2 10 mM 485.94 S1011179324-69-7 10 mM 384.24 S1013

380843-75-4 10 mM 530.45 S1014288383-20-0 10 mM 450.51 S1017

405169-16-6 10 mM 392.43 S1018267243-28-7 10 mM 485.94 S1019

212631-79-3 10 mM 478.67 S1020302962-49-8 10 mM 488.01 S1021

572924-54-0 10 mM 990.21 S1022183319-69-9 10 mM 429.90 S1023

184475-35-2 10 mM 446.90 S1025220127-57-1 10 mM 589.71 S1026

388082-77-7 10 mM 925.46 S1028191732-72-6 10 mM 259.26 S1029

857876-30-3 10 mM 569.44 S1032641571-10-0 10 mM 529.52 S1033

475489-16-8 10 mM 439.55 S1034635702-64-6 10 mM 473.98 S1035

391210-10-9 10 mM 482.19 S1036371935-74-9 10 mM 348.36 S1038

53123-88-9 10 mM 914.18 S1039475207-59-1 10 mM 637.03 S1040

315702-99-9 10 mM 267.35 S1041341031-54-7 10 mM 532.56 S1042

387867-13-2 10 mM 562.70 S1043162635-04-3 10 mM 1030.29 S1044

58880-19-6 10 mM 302.40 S1045443913-73-3 10 mM 475.35 S1046

149647-78-9 10 mM 264.30 S1047639089-54-6 10 mM 464.59 S1048

129830-38-2 10 mM 320.26 S1049488832-69-5 10 mM 400.50 S1052

209783-80-2 10 mM 376.41 S1053170364-57-5 10 mM 515.61 S1055

714971-09-2 10 mM 567.01 S1056803712-79-0 10 mM 413.49 S1057

763113-22-0 10 mM 434.46 S1060890090-75-2 10 mM 581.50 S1061

790299-79-5 10 mM 498.64 S1064

957054-30-7 10 mM 513.64 S1065

305350-87-2 10 mM 335.35 S1066301836-41-9 10 mM 384.39 S1067

877399-52-5 10 mM 450.34 S1068747412-49-3 10 mM 465.54 S1069

477575-56-7 10 mM 641.61 S107065673-63-4 10 mM 409.23 S1071

475110-96-4 10 mM 417.41 S1072280744-09-4 10 mM 371.22 S1075

152121-47-6 10 mM 377.43 S1076152121-30-7 10 mM 331.34 S1077

1032350-13-2 10 mM 480.39 S1078183322-45-4 10 mM 396.67 S1079

658084-23-2 10 mM 568.09 S1080879085-55-9 10 mM 421.30 S1082

649735-46-6 10 mM 370.38 S1084414864-00-9 10 mM 318.35 S1085

160003-66-7 10 mM 292.03 S1087475488-23-4 10 mM 453.58 S1088

783355-60-2 10 mM 397.42 S1090867160-71-2 10 mM 421.49 S1091

587871-26-9 10 mM 395.49 S10921089283-49-7 10 mM 851.96 S1093

956905-27-4 10 mM 372.38 S1094404951-53-7 10 mM 379.46 S1095

875320-29-9 10 mM 394.48 S1096957217-65-1 10 mM 431.39 S1097

459868-92-9 10 mM 421.36 S1098869363-13-3 10 mM 476.86 S1100

212141-51-0 10 mM 419.73 S11011173097-76-1 10 mM 426.56 S1102

331771-20-1 10 mM 513.59 S1103905281-76-7 10 mM 334.37 S1104

154447-36-6 10 mM 307.34 S1105742112-33-0 10 mM 460.45 S1106

827318-97-8 10 mM 474.55 S1107761439-42-3 10 mM 614.20 S1108

755038-02-9 10 mM 521.66 S1109172732-68-2 10 mM 380.39 S1110

849217-64-7 10 mM 632.65 S11111022150-57-7 10 mM 359.41 S1112

937174-76-0 10 mM 425.48 S1113943540-75-8 10 mM 377.35 S1114

603139-19-1 10 mM 525.56 S1115827022-32-2 10 mM 483.99 S1116

35943-35-2 10 mM 320.30 S1117956958-53-5 10 mM 448.52 S1118

849217-68-1 10 mM 501.51 S1119159351-69-6 10 mM 958.22 S1120

877877-35-5 10 mM 573.70 S1121

726169-73-9 10 mM 396.44 S1122

154229-19-3 10 mM 349.51 S11231001645-58-4 10 mM 506.02 S1129

781661-94-7 10 mM 443.29 S11303544-24-9 10 mM 136.15 S1132

1028486-01-2 10 mM 518.92 S1133896466-04-9 10 mM 381.43 S1134

150399-23-8 10 mM 471.37 S1135649735-63-7 10 mM 441.46 S1138

850173-95-4 10 mM 428.95 S1139401900-40-1 10 mM 441.36 S1140

75747-14-7 10 mM 585.69 S1141467214-21-7 10 mM 653.21 S1142

133550-30-8 10 mM 294.30 S1143873054-44-5 10 mM 392.49 S1144

345627-80-7 10 mM 380.53 S11454449-51-8 10 mM 411.62 S1146

722544-51-6 10 mM 507.56 S1147114977-28-5 10 mM 807.88 S1148

122111-03-9 10 mM 299.66 S114933069-62-4 10 mM 853.91 S1150

918505-84-7 10 mM 413.83 S1152186692-46-6 10 mM 354.45 S1153

1146618-41-8 10 mM 527.04 S1154501919-59-1 10 mM 365.36 S1155

154361-50-9 10 mM 359.35 S11561030612-90-8 10 mM 467.25 S1158

888216-25-9 10 mM 364.40 S1159289905-88-0 10 mM 344.84 S1160

912999-49-6 10 mM 409.52 S1163417716-92-8 10 mM 426.85 S1164

141430-65-1 10 mM 371.41 S116515663-27-1 10 mM 300.05 S1166

537705-08-1 10 mM 469.53 S11671069-66-5 10 mM 166.19 S1168

663619-89-4 10 mM 364.44 S11691214265-56-1 10 mM 464.95 S1170

693228-63-6 10 mM 368.46 S1171881202-45-5 10 mM 328.41 S1172

1213269-23-8 10 mM 494.18 S1173841205-47-8 10 mM 389.33 S1174

848695-25-0 10 mM 318.76 S1175167869-21-8 10 mM 267.28 S1177

755037-03-7 10 mM 482.82 S11781214265-57-2 10 mM 481.01 S1179

284028-89-3 10 mM 312.31 S1180934353-76-1 10 mM 375.47 S1181

850876-88-9 10 mM 731.83 S1183155213-67-5 10 mM 720.94 S1185

321674-73-1 10 mM 331.36 S1186

677338-12-4 10 mM 351.36 S1187

120511-73-1 10 mM 293.37 S1188170729-80-3 10 mM 534.43 S1189

90357-06-5 10 mM 430.37 S1190129453-61-8 10 mM 606.77 S1191

112887-68-0 10 mM 458.49 S119250-35-1 10 mM 258.23 S1193

1012054-59-9 10 mM 434.49 S1194426219-18-3 10 mM 307.35 S1195

107868-30-4 10 mM 296.40 S119698319-26-7 10 mM 372.54 S1197

97682-44-5 10 mM 586.68 S11984291-63-8 10 mM 285.69 S1199

2353-33-5 10 mM 228.21 S120016208-51-8 10 mM 326.34 S1201

164656-23-9 10 mM 528.53 S1202372196-77-5 10 mM 488.74 S1205

104344-23-2 10 mM 441.52 S1206475108-18-0 10 mM 454.86 S1207

25316-40-9 10 mM 579.98 S120851-21-8 10 mM 130.08 S1209

59-05-2 10 mM 454.44 S12103543-75-7 10 mM 394.72 S1212

121032-29-9 10 mM 297.27 S12139041-93-4 10 mM 1512.62 S1214

41575-94-4 10 mM 371.25 S12151403764-72-6 10 mM 347.39 S1216

50-18-0 10 mM 261.09 S1217123318-82-1 10 mM 303.68 S1218

371942-69-7 10 mM 467.48 S1219728033-96-3 10 mM 443.44 S1220

4342-03-4 10 mM 182.18 S122156390-09-1 10 mM 579.98 S1223

61825-94-3 10 mM 397.29 S122433419-42-0 10 mM 588.56 S1225

938440-64-3 10 mM 465.54 S122682640-04-8 10 mM 510.04 S1227

57852-57-0 10 mM 533.95 S122875607-67-9 10 mM 365.21 S1229

119413-54-6 10 mM 457.91 S1231362-07-2 10 mM 302.41 S1233

65678-07-1 10 mM 305.17 S1234112809-51-5 10 mM 285.30 S1235

85622-93-1 10 mM 194.15 S12372068-78-2 10 mM 923.04 S1241

138112-76-2 10 mM 243.30 S1243850879-09-3 10 mM 447.51 S1244

57-22-7 10 mM 824.96 S1248443797-96-4 10 mM 394.36 S1249

915087-33-1 10 mM 464.44 S1250

65928-58-7 10 mM 311.42 S1251

106308-44-5 10 mM 238.19 S1256171228-49-2 10 mM 700.78 S1257

150322-43-3 10 mM 373.44 S1258196597-26-9 10 mM 259.34 S1259

364782-34-3 10 mM 393.87 S1260169590-42-5 10 mM 381.37 S1261

1146699-66-2 10 mM 520.88 S1262219580-11-7 10 mM 523.67 S1264

1062169-56-5 10 mM 495.53 S1266918504-65-1 10 mM 489.92 S1267

371242-69-2 10 mM 397.43 S1268702675-74-9 10 mM 591.47 S1274

702674-56-4 10 mM 471.35 S127571675-85-9 10 mM 369.48 S1280

72432-10-1 10 mM 219.24 S128185650-56-2 10 mM 401.84 S1283

86541-74-4 10 mM 460.95 S12841235-82-1 10 mM 347.92 S1285

7689-03-4 10 mM 348.35 S128861422-45-5 10 mM 257.26 S1289

34157-83-0 10 mM 450.61 S129083881-52-1 10 mM 461.81 S1291

132203-70-4 10 mM 492.52 S129373963-72-1 10 mM 369.46 S1294

152044-53-6 10 mM 493.66 S129750-91-9 10 mM 246.19 S1299

17902-23-7 10 mM 200.17 S13003778-73-2 10 mM 261.09 S1302

595-33-5 10 mM 384.51 S130450-44-2 10 mM 152.18 S1305

118072-93-8 10 mM 272.09 S1314355025-24-0 10 mM 474.96 S1315

1002304-34-8 10 mM 383.40 S1316553-21-9 10 mM 232.32 S1319

50-02-2 10 mM 392.46 S132277883-43-3 10 mM 547.58 S1324

476-66-4 10 mM 302.19 S132741340-25-4 10 mM 287.35 S1328

33125-97-2 10 mM 244.29 S132978755-81-4 10 mM 303.29 S1332

56296-78-7 10 mM 345.79 S133375507-68-5 10 mM 420.39 S1334

61718-82-9 10 mM 434.41 S133660142-95-2 10 mM 207.70 S1338

1953-04-4 10 mM 368.27 S1339446-72-0 10 mM 270.24 S1342

93479-97-1 10 mM 490.62 S1344107007-99-8 10 mM 348.87 S1345

677297-51-7 10 mM 346.34 S1352

65277-42-1 10 mM 531.43 S1353

103577-45-3 10 mM 369.36 S1354137-58-6 10 mM 234.34 S1357

79794-75-5 10 mM 382.88 S1358124750-99-8 10 mM 462.01 S1359

958852-01-2 10 mM 333.36 S1360875337-44-3 10 mM 517.60 S1361

1225497-78-8 10 mM 473.47 S1362228559-41-9 10 mM 469.41 S1363

152044-54-7 10 mM 507.68 S1364729607-74-3 10 mM 410.42 S1366

69408-81-7 10 mM 283.33 S1367130693-82-2 10 mM 360.90 S1375

60282-87-3 10 mM 310.43 S137667392-87-4 10 mM 366.49 S1377

941678-49-5 10 mM 306.37 S13784759-48-2 10 mM 300.44 S1379

192725-17-0 10 mM 628.80 S138021535-47-7 10 mM 300.83 S1382

38304-91-5 10 mM 209.25 S138350924-49-7 10 mM 259.22 S1384

112885-42-4 10 mM 614.02 S138582956-11-4 10 mM 539.58 S1386

57149-08-3 10 mM 465.41 S138773590-58-6 10 mM 345.42 S1389

99614-01-4 10 mM 329.82 S139028721-07-5 10 mM 252.27 S1391

257933-82-7 10 mM 467.92 S1392501-36-0 10 mM 228.24 S1396

119302-91-9 10 mM 609.68 S13973056-17-5 10 mM 224.21 S1398

202138-50-9 10 mM 635.51 S1400147127-20-6 10 mM 287.21 S1401

13647-35-3 10 mM 329.43 S140481403-68-1 10 mM 425.91 S1409

648450-29-7 10 mM 257.27 S1410120202-66-6 10 mM 419.90 S1415

62996-74-1 10 mM 466.53 S142199873-43-5 10 mM 243.69 S1422

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61413-54-5 10 mM 275.34 S1430171599-83-0 10 mM 666.70 S1431

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64461-82-1 10 mM 290.17 S143797240-79-4 10 mM 339.36 S1438

375815-87-5 10 mM 361.35 S144099300-78-4 10 mM 313.86 S1441

137234-62-9 10 mM 349.31 S1442

111406-87-2 10 mM 236.29 S1443

1158838-45-9 10 mM 588.07 S1451336113-53-2 10 mM 517.06 S1452

192185-72-1 10 mM 489.40 S1453398493-79-3 10 mM 501.62 S1454

153259-65-5 10 mM 343.42 S1455186497-07-4 10 mM 424.43 S1456

229975-97-7 10 mM 802.93 S14571226056-71-8 10 mM 311.36 S1459

129-56-6 10 mM 220.23 S146082419-36-1 10 mM 361.37 S1463

186826-86-8 10 mM 437.89 S146541294-56-8 10 mM 400.64 S1468

252916-29-3 10 mM 310.35 S1470202825-46-5 10 mM 398.45 S1472

864082-47-3 10 mM 432.37 S14741236699-92-5 10 mM 431.20 S1475

356559-20-1 10 mM 343.42 S1476579-13-5 10 mM 791.06 S1478

1026785-55-6 10 mM 445.61 S1480167465-36-3 10 mM 636.99 S1481

1009119-64-5 10 mM 738.88 S1482852475-26-4 10 mM 314.31 S1484

173529-46-9 10 mM 424.47 S1485497839-62-0 10 mM 440.58 S1486

718630-59-2 10 mM 361.48 S1487143388-64-1 10 mM 371.93 S1488

593960-11-3 10 mM 389.88 S1489943319-70-8 10 mM 532.56 S1490

21679-14-1 10 mM 285.23 S1491862507-23-1 10 mM 612.74 S1494

146464-95-1 10 mM 477.47 S1497847559-80-2 10 mM 480.41 S1498

128794-94-5 10 mM 433.49 S1501479-18-5 10 mM 254.24 S1504

107133-36-8 10 mM 441.60 S1506138402-11-6 10 mM 428.53 S1507

171596-29-5 10 mM 389.40 S1512929016-96-6 10 mM 358.48 S1515

57469-77-9 10 mM 352.47 S1518942947-93-5 10 mM 497.02 S1519

238750-77-1 10 mM 406.47 S15221349796-36-6 10 mM 599.66 S1523

844442-38-2 10 mM 382.24 S1524955365-80-7 10 mM 500.60 S1525

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422513-13-1 10 mM 516.65 S15291094614-84-2 10 mM 426.51 S1530

1094614-85-3 10 mM 440.54 S1531

860352-01-8 10 mM 362.42 S1532

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117570-53-3 10 mM 282.29 S1537402957-28-2 10 mM 679.85 S1538

361442-04-8 10 mM 315.41 S154049843-98-3 10 mM 248.71 S1541

444912-48-5 10 mM 503.33 S1544288150-92-5 10 mM 356.37 S1545

461432-26-8 10 mM 408.87 S1548152520-56-4 10 mM 441.90 S1549

74150-27-9 10 mM 334.37 S15501009298-09-2 10 mM 465.54 S1555

1191951-57-1 10 mM 409.61 S1556286370-15-8 10 mM 416.86 S1557

857531-00-1 10 mM 337.85 S15581025720-94-8 10 mM 512.89 S1561

936727-05-8 10 mM 452.41 S156519171-19-8 10 mM 273.24 S1567

391210-00-7 10 mM 561.09 S1568925701-49-1 10 mM 547.67 S1570

1397219-81-6 10 mM 416.99 S1572105628-07-7 10 mM 327.83 S1573

285983-48-4 10 mM 527.66 S1574948557-43-5 10 mM 439.53 S1577

139481-59-7 10 mM 440.45 S1578827022-33-3 10 mM 573.66 S1579

130964-39-5 10 mM 519.28 S1582601514-19-6 10 mM 318.33 S1590

58970-76-6 10 mM 308.37 S1591503612-47-3 10 mM 459.50 S1593

425386-60-3 10 mM 361.44 S1594144689-63-4 10 mM 558.59 S1604

145202-66-0 10 mM 391.47 S1607101-26-8 10 mM 261.12 S1608

62893-19-0 10 mM 645.67 S1611160970-54-7 10 mM 495.53 S1613

1744-22-5 10 mM 234.20 S1614106266-06-2 10 mM 410.48 S1615

616-91-1 10 mM 163.19 S1623121268-17-5 10 mM 326.13 S1624

26159-34-2 10 mM 252.24 S162655981-09-4 10 mM 307.28 S1627

96829-58-2 10 mM 495.73 S1629315-30-0 10 mM 136.11 S1630

17795-21-0 10 mM 159.10 S1631107753-78-6 10 mM 575.68 S1633

15687-27-1 10 mM 206.28 S1638161814-49-9 10 mM 505.63 S1639

555-30-6 10 mM 211.21 S1642

22071-15-4 10 mM 254.28 S1645

74103-07-4 10 mM 376.40 S1646147-94-4 10 mM 243.22 S1648

139264-17-8 10 mM 287.36 S164984680-54-6 10 mM 348.40 S1657

75695-93-1 10 mM 371.39 S166253-16-7 10 mM 270.37 S1665

2022-85-7 10 mM 129.09 S1666125-84-8 10 mM 232.28 S1672

317-34-0 10 mM 420.43 S1673298-46-4 10 mM 236.27 S1693

56211-40-6 10 mM 348.42 S169869655-05-6 10 mM 236.23 S1702

76584-70-8 10 mM 310.41 S1703143491-57-0 10 mM 247.25 S1704

134678-17-4 10 mM 229.26 S1706107724-20-9 10 mM 414.49 S1707

36322-90-4 10 mM 331.35 S171395058-81-4 10 mM 263.20 S1714

142340-99-6 10 mM 501.47 S17187481-89-2 10 mM 211.22 S1719

144598-75-4 10 mM 426.48 S1724144701-48-4 10 mM 514.62 S1738

129618-40-2 10 mM 266.30 S1742161973-10-0 10 mM 713.12 S1743

66085-59-4 10 mM 418.44 S174763675-72-9 10 mM 388.41 S1748

5633-20-5 10 mM 357.49 S1754111974-72-2 10 mM 883.09 S1763

113-59-7 10 mM 315.86 S1771154-42-7 10 mM 167.19 S1774

89778-27-8 10 mM 598.08 S1776320-67-2 10 mM 244.20 S1782

1405-89-6 10 mM 1486.07 S179179902-63-9 10 mM 418.57 S1792

87333-19-5 10 mM 416.51 S179366357-59-3 10 mM 350.86 S1801

2627-69-2 10 mM 258.23 S180260-31-1 10 mM 181.66 S1805

21829-25-4 10 mM 346.33 S1808111470-99-6 10 mM 567.05 S1813

113-92-8 10 mM 390.86 S181663659-19-8 10 mM 343.89 S1827

5875-06-9 10 mM 330.85 S1828103177-37-3 10 mM 481.50 S1829

72956-09-3 10 mM 406.47 S183164872-77-1 10 mM 474.79 S1833

83905-01-5 10 mM 748.98 S183531430-15-6 10 mM 313.28 S1837

13010-47-4 10 mM 233.70 S1840

51481-61-9 10 mM 252.34 S1845

14976-57-9 10 mM 459.96 S184760628-96-8 10 mM 310.39 S1854

392-17-7 10 mM 684.81 S18562809-21-4 10 mM 206.03 S1857

129938-20-1 10 mM 341.87 S18691197-18-8 10 mM 157.21 S1875

93793-83-0 10 mM 384.90 S188072509-76-3 10 mM 384.25 S1885

76963-41-2 10 mM 331.46 S189028860-95-9 10 mM 226.23 S1891

137862-53-4 10 mM 435.52 S1894105826-92-4 10 mM 320.81 S1898

15307-79-6 10 mM 318.13 S190388150-42-9 10 mM 408.88 S1905

13311-84-7 10 mM 276.21 S190893957-55-2 10 mM 433.45 S1909

1508-75-4 10 mM 284.35 S1913145-13-1 10 mM 316.48 S1914

723-46-6 10 mM 253.28 S191557381-26-7 10 mM 256.09 S1929

76095-16-4 10 mM 492.52 S19411115-70-4 10 mM 165.62 S1950

13710-19-5 10 mM 261.70 S195952549-17-4 10 mM 255.27 S1960

77191-36-7 10 mM 246.30 S196965141-46-0 10 mM 211.17 S1971

54965-24-1 10 mM 563.64 S19726284-40-8 10 mM 195.21 S1974

129722-12-9 10 mM 448.39 S1975155-41-9 10 mM 398.29 S1978

19774-82-4 10 mM 681.77 S197973-24-5 10 mM 135.13 S1981

321-30-2 10 mM 368.33 S19822922-28-3 10 mM 171.59 S1983

53885-35-1 10 mM 300.25 S1984103890-78-4 10 mM 455.54 S1994

366-70-1 10 mM 257.76 S199599614-02-5 10 mM 293.36 S1996

13721-39-6 10 mM 183.91 S2000697761-98-1 10 mM 447.88 S2001

376348-65-1 10 mM 513.67 S2003518048-05-0 10 mM 444.42 S2005

58-14-0 10 mM 248.71 S2006191217-81-9 10 mM 302.26 S2011

950762-95-5 10 mM 296.32 S2012869288-64-2 10 mM 491.49 S2013

582315-72-8 10 mM 345.34 S201494055-76-2 10 mM 499.64 S2015

1291074-87-7 10 mM 525.56 S2018

43229-80-7 10 mM 402.40 S2020

34580-14-8 10 mM 425.50 S202464887-14-5 10 mM 423.94 S2025

15291-75-5 10 mM 408.40 S202658-96-8 10 mM 244.20 S2029

30484-77-6 10 mM 477.42 S203090098-04-7 10 mM 370.79 S2032

82159-09-9 10 mM 319.40 S2035145040-37-5 10 mM 610.66 S2037

65-28-1 10 mM 377.46 S203851803-78-2 10 mM 308.31 S2040

427-51-0 10 mM 416.94 S204241100-52-1 10 mM 215.76 S2043

969-33-5 10 mM 323.86 S20443094-09-5 10 mM 246.19 S2045

112529-15-4 10 mM 392.90 S204670374-39-9 10 mM 371.82 S2047

135459-87-9 10 mM 513.49 S205062571-86-2 10 mM 217.29 S2051

4682-36-4 10 mM 461.50 S2054103766-25-2 10 mM 145.54 S2055

70024-40-7 10 mM 459.92 S205975330-75-5 10 mM 404.54 S2061

118288-08-7 10 mM 431.55 S206575438-57-2 10 mM 241.68 S2066

78712-43-3 10 mM 264.71 S2067145525-41-3 10 mM 668.88 S2073

302543-62-0 10 mM 393.89 S207583915-83-7 10 mM 405.49 S2076

134523-03-8 10 mM 1155.34 S207776824-35-6 10 mM 337.45 S2078

82586-52-5 10 mM 535.03 S2079167221-71-8 10 mM 456.32 S2080

92077-78-6 10 mM 435.51 S208150-42-0 10 mM 347.88 S2082

136434-34-9 10 mM 333.88 S208439133-31-8 10 mM 387.47 S2085

148849-67-6 10 mM 505.05 S2086129101-54-8 10 mM 400.42 S2087

145108-58-3 10 mM 236.74 S2090659-18-7 10 mM 307.43 S2091

90038-01-0 10 mM 222.71 S209288889-14-9 10 mM 585.64 S2095

181183-52-8 10 mM 469.55 S2096177036-94-1 10 mM 378.42 S2097

153559-49-0 10 mM 348.00 S2098110221-44-8 10 mM 513.07 S2099

56974-61-9 10 mM 417.48 S2101161735-79-1 10 mM 267.34 S2102

16676-29-2 10 mM 377.86 S2103

23672-07-3 10 mM 341.43 S2104

123040-16-4 10 mM 386.27 S2106108612-45-9 10 mM 432.49 S2107

42461-84-7 10 mM 491.46 S210842971-09-5 10 mM 350.45 S2110

231277-92-2 10 mM 581.06 S2111132810-10-7 10 mM 367.50 S2112

96946-42-8 10 mM 1243.48 S2113122647-32-9 10 mM 885.23 S2118

57149-07-2 10 mM 392.49 S212685416-73-5 10 mM 275.34 S2127

198480-56-7 10 mM 507.06 S21285908-99-6 10 mM 694.83 S2130

162401-32-3 10 mM 403.21 S213160142-96-3 10 mM 171.24 S2133

869357-68-6 10 mM 461.23 S21341032823-75-8 10 mM 456.56 S2149

698387-09-6 10 mM 557.04 S2150956697-53-3 10 mM 485.50 S2151

124431-80-7 10 mM 535.98 S2153211915-06-9 10 mM 627.73 S2154

1234703-40-2 10 mM 559.81 S21551262036-50-9 10 mM 390.41 S2156

1258861-20-9 10 mM 512.50 S21571000669-72-6 10 mM 332.40 S2158

161715-24-8 10 mM 497.63 S21591255517-76-0 10 mM 390.41 S2163

112960-16-4 10 mM 285.77 S2168147098-20-2 10 mM 500.57 S2169

732302-99-7 10 mM 475.97 S2170328543-09-5 10 mM 320.39 S2178

1229236-86-5 10 mM 469.94 S21791072833-77-2 10 mM 361.03 S2180

1201902-80-8 10 mM 517.12 S2181940929-33-9 10 mM 553.52 S2182

872511-34-7 10 mM 560.48 S21831050500-29-2 10 mM 621.08 S2185

694433-59-5 10 mM 335.40 S2186166518-60-1 10 mM 501.72 S2187

848942-61-0 10 mM 473.93 S2192929095-18-1 10 mM 543.60 S2193

841290-81-1 10 mM 628.63 S21941025065-69-3 10 mM 405.42 S2198

173334-58-2 10 mM 609.83 S21991174046-72-0 10 mM 468.84 S2201

940310-85-0 10 mM 503.48 S2202183320-51-6 10 mM 415.87 S2205

1025687-58-4 10 mM 624.42 S2206900185-01-5 10 mM 397.43 S2207

566-48-3 10 mM 302.41 S2208

1201898-17-0 10 mM 967.02 S2209

905586-69-8 10 mM 354.36 S2214208255-80-5 10 mM 432.46 S2215

366017-09-6 10 mM 468.47 S2216136572-09-3 10 mM 677.18 S2217

1092351-67-1 10 mM 308.34 S22181056634-68-4 10 mM 414.46 S2219

405554-55-4 10 mM 453.54 S2220811803-05-1 10 mM 493.58 S2221

901-47-3 10 mM 342.41 S2225870281-82-6 10 mM 415.42 S2226

900185-02-6 10 mM 489.53 S2227496775-61-2 10 mM 442.47 S2229

700874-72-2 10 mM 369.42 S2230332012-40-5 10 mM 409.83 S2231

74050-98-9 10 mM 395.43 S2232161796-78-7 10 mM 367.40 S2233

755038-65-4 10 mM 618.81 S2235914913-88-5 10 mM 406.43 S2238

286930-03-8 10 mM 527.65 S2240856243-80-6 10 mM 384.27 S2243

935881-37-1 10 mM 312.36 S22441080622-86-1 10 mM 349.35 S2245

154229-18-2 10 mM 391.55 S2246944396-07-0 10 mM 410.39 S2247

1009820-21-6 10 mM 349.77 S2248102518-79-6 10 mM 242.32 S2251

90-33-5 10 mM 176.17 S2256481-72-1 10 mM 270.24 S2259

520-36-5 10 mM 270.24 S2262497-76-7 10 mM 272.25 S2263

88495-63-0 10 mM 384.42 S2265464-92-6 10 mM 488.70 S2266

491-67-8 10 mM 270.24 S226821967-41-9 10 mM 446.36 S2269

35825-57-1 10 mM 296.36 S2285485-35-8 10 mM 190.24 S2287

520-33-2 10 mM 302.27 S230835354-74-6 10 mM 266.33 S2310

489-32-7 10 mM 676.66 S2312491-70-3 10 mM 286.24 S2320

519-02-8 10 mM 248.36 S232213241-33-3 10 mM 610.56 S2332

20554-84-1 10 mM 248.32 S23413681-99-0 10 mM 432.38 S2346

53003-10-4 10 mM 751.00 S235294-07-5 10 mM 167.21 S2362

56-69-9 10 mM 220.22 S23741415-73-2 10 mM 418.39 S2375

19057-60-4 10 mM 869.04 S2379

479-41-4 10 mM 262.26 S2386

117-39-5 10 mM 302.24 S2391480-41-1 10 mM 272.25 S2394

10338-51-9 10 mM 300.30 S239667920-52-9 10 mM 220.15 S2401

518-34-3 10 mM 622.75 S2403481-74-3 10 mM 254.24 S2406

83207-58-3 10 mM 784.97 S24155289-74-7 10 mM 480.63 S2417

19685-09-7 10 mM 364.35 S2423498-02-2 10 mM 166.17 S2425

483-14-7 10 mM 355.43 S24375985-28-4 10 mM 203.67 S2438

64-77-7 10 mM 270.35 S244366575-29-9 10 mM 410.50 S2449

531-95-3 10 mM 242.27 S2450665-66-7 10 mM 187.70 S2451

31677-93-7 10 mM 276.20 S245214919-77-8 10 mM 293.70 S2453

18010-40-7 10 mM 324.89 S2454590-63-6 10 mM 196.68 S2455

69-09-0 10 mM 355.33 S24564205-91-8 10 mM 266.50 S2458

5786-21-0 10 mM 326.82 S2459104632-26-0 10 mM 211.33 S2460

57808-66-9 10 mM 425.91 S2461120011-70-3 10 mM 416.00 S2462

50-27-1 10 mM 288.39 S246667-73-2 10 mM 452.50 S2470

65-29-2 10 mM 891.53 S247184-16-2 10 mM 270.37 S2473

152459-95-5 10 mM 493.60 S247534552-83-5 10 mM 513.50 S2480

89226-50-6 10 mM 610.70 S248189226-75-5 10 mM 683.62 S2482

78415-72-2 10 mM 211.22 S248470476-82-3 10 mM 517.40 S2485

105816-04-4 10 mM 317.42 S2489114-80-7 10 mM 303.20 S2490

39562-70-4 10 mM 360.37 S2491132539-06-1 10 mM 312.44 S2493

140462-76-6 10 mM 373.87 S24942315-02-8 10 mM 296.84 S2495

82571-53-7 10 mM 228.25 S249615500-66-0 10 mM 732.67 S2497

63-92-3 10 mM 340.30 S249934183-22-7 10 mM 377.90 S2500

81110-73-8 10 mM 385.48 S2503155141-29-0 10 mM 473.50 S2505

51022-70-9 10 mM 337.39 S2507

114-49-8 10 mM 384.26 S2508

959-24-0 10 mM 308.82 S25092447-57-6 10 mM 310.33 S2511

59804-37-4 10 mM 337.38 S2512224785-90-4 10 mM 579.11 S2515

23076-35-9 10 mM 256.79 S251610347-81-6 10 mM 313.86 S2517

550-99-2 10 mM 246.74 S251951-42-3 10 mM 333.29 S2521

51-43-4 10 mM 183.20 S2522329-65-7 10 mM 183.20 S2523

630-93-3 10 mM 274.25 S252457-41-0 10 mM 252.27 S2525

72-48-0 10 mM 240.21 S252662-31-7 10 mM 189.64 S2529

4460-86-0 10 mM 196.20 S253123239-51-2 10 mM 323.81 S2533

17321-77-6 10 mM 351.31 S2541834-28-6 10 mM 241.72 S2542

498-45-3 10 mM 155.19 S2545139404-48-1 10 mM 490.43 S2547

85700-55-6 10 mM 191.66 S254810405-02-4 10 mM 427.96 S2549

124937-52-6 10 mM 475.57 S255079307-93-0 10 mM 418.36 S2552

486-35-1 10 mM 178.14 S255481103-11-9 10 mM 747.95 S2555

122320-73-4 10 mM 357.43 S255617440-83-4 10 mM 302.12 S2560

50-41-9 10 mM 598.08 S2561304-20-1 10 mM 196.64 S2562

51-30-9 10 mM 247.72 S256671-58-9 10 mM 386.52 S2567

61-76-7 10 mM 203.67 S2569136-47-0 10 mM 300.82 S2573

62-44-2 10 mM 179.22 S257730516-87-1 10 mM 267.24 S2579

82586-55-8 10 mM 474.98 S258125332-39-2 10 mM 408.32 S2582

980-71-2 10 mM 435.31 S2585111025-46-8 10 mM 356.44 S2590

150683-30-0 10 mM 448.94 S259321187-98-4 10 mM 323.41 S2601

53164-05-9 10 mM 415.82 S26024991-65-5 10 mM 168.17 S2603

53-43-0 10 mM 288.43 S260484371-65-3 10 mM 429.59 S2606

50264-69-2 10 mM 321.16 S2610434-03-7 10 mM 312.45 S2611

300-08-3 10 mM 236.11 S2614

108341-18-0 10 mM 337.28 S2615

1035555-63-5 10 mM 504.23 S26171062368-24-4 10 mM 406.48 S2618

801312-28-7 10 mM 518.58 S2620602306-29-6 10 mM 371.46 S2621

1092788-83-4 10 mM 319.36 S2622936890-98-1 10 mM 406.44 S2624

901119-35-5 10 mM 580.46 S2625911222-45-2 10 mM 436.30 S2626

1310693-92-5 10 mM 371.86 S26271197160-78-3 10 mM 615.73 S2628

501925-31-1 10 mM 311.72 S2629405911-17-3 10 mM 618.51 S2630

546141-08-6 10 mM 338.40 S2631357263-13-9 10 mM 406.43 S2632

1020172-07-9 10 mM 553.59 S2634885499-61-6 10 mM 341.84 S2635

1166227-08-2 10 mM 393.53 S26361374598-80-7 10 mM 533.63 S2637

503468-95-9 10 mM 413.49 S2638908112-43-6 10 mM 464.48 S2639

908115-27-5 10 mM 521.53 S26561086062-66-9 10 mM 505.50 S2658

207679-81-0 10 mM 341.49 S2659471905-41-6 10 mM 442.90 S2660

1144068-46-1 10 mM 519.60 S2661146714-97-8 10 mM 531.95 S2663

30299-08-2 10 mM 468.58 S266452214-84-3 10 mM 289.15 S2665

1196109-52-0 10 mM 456.46 S26661051375-16-6 10 mM 419.38 S2667

1062161-90-3 10 mM 528.61 S2668192927-92-7 10 mM 430.94 S2669

552325-73-2 10 mM 358.44 S2670900515-16-4 10 mM 305.28 S2671

939791-38-5 10 mM 665.66 S2672871700-17-3 10 mM 615.39 S2673

959122-11-3 10 mM 428.48 S2674193611-72-2 10 mM 479.87 S2677

58131-57-0 10 mM 279.25 S2678131740-09-5 10 mM 438.30 S2679

936563-96-1 10 mM 440.50 S2680648449-76-7 10 mM 285.22 S2681

1218777-13-9 10 mM 289.28 S2682405168-58-3 10 mM 419.91 S2683

1138549-36-6 10 mM 513.61 S2684819812-04-9 10 mM 574.66 S2685

1092499-93-8 (free base) 10 mM 563.47 S2686741713-40-6 10 mM 441.45 S2688

1062159-35-6 10 mM 494.59 S2689

851881-60-2 10 mM 369.36 S2690

21102-95-4 10 mM 458.42 S2691936091-14-4 10 mM 509.67 S2692

629664-81-9 10 mM 438.47 S26941032754-93-0 10 mM 498.60 S2696

844499-71-4 10 mM 360.39 S2697199864-87-3 10 mM 281.33 S2698

1007207-67-1 10 mM 377.42 S2699897016-82-9 10 mM 431.53 S2700

1116235-97-2 10 mM 532.57 S2703700874-71-1 10 mM 441.52 S2704

209984-56-5 10 mM 463.48 S271130562-34-6 10 mM 560.64 S2713

209984-57-6 10 mM 479.48 S2714186392-40-5 10 mM 399.87 S2717

934541-31-8 10 mM 504.64 S2718945595-80-2 10 mM 503.58 S2719

208260-29-1 10 mM 389.45 S272075530-68-6 10 mM 385.37 S2721

244218-51-7 10 mM 447.96 S2722942487-16-3 10 mM 474.48 S2725

586379-66-0 10 mM 477.30 S27261110813-31-4 10 mM 469.94 S2727

153436-53-4 10 mM 315.75 S2728264218-23-7 10 mM 359.72 S2729

670220-88-9 10 mM 443.54 S27301124329-14-1 10 mM 452.55 S2731

936091-26-8 10 mM 524.68 S2736315183-21-2 10 mM 392.49 S2738

1173204-81-3 10 mM 570.65 S2739942918-07-2 10 mM 507.63 S2740

845714-00-3 10 mM 213.24 S27421013101-36-4 10 mM 425.48 S2743

1095382-05-0 10 mM 551.48 S2744252935-94-7 10 mM 486.31 S2745

878739-06-1 10 mM 451.52 S2746913376-83-7 10 mM 539.58 S2747

875446-37-0 10 mM 637.51 S27481245537-68-1 10 mM 650.60 S2749

452342-67-5 10 mM 425.48 S2750802539-81-7 10 mM 460.57 S2751

937265-83-3 10 mM 569.63 S27521071992-99-8 10 mM 561.71 S2754

845272-21-1 10 mM 466.94 S275519545-26-7 10 mM 428.43 S2758

1339928-25-4 10 mM 508.55 S2759842133-18-0 10 mM 444.52 S2760

1185763-69-2 10 mM 340.38 S27611256580-46-7 10 mM 482.62 S2762

869901-69-9 10 mM 461.87 S2765

5142-23-4 10 mM 149.15 S2767

779353-01-4 10 mM 396.49 S2768852433-84-2 10 mM 572.59 S2769

1010085-13-8 10 mM 461.94 S2770211513-37-0 10 mM 389.59 S2772

501951-42-4 10 mM 429.23 S2773917879-39-1 10 mM 495.55 S2774

31430-18-9 10 mM 301.32 S277595809-78-2 10 mM 388.59 S2776

1373615-35-0 10 mM 436.96 S2777666260-75-9 10 mM 449.25 S2778

251456-60-7 10 mM 307.39 S2779213261-59-7 10 mM 292.37 S2781

278779-30-9 10 mM 542.84 S27821009298-59-2 10 mM 462.54 S2783

871026-44-7 10 mM 547.96 S2784944261-79-4 10 mM 357.79 S2785

1029712-80-8 10 mM 412.42 S2788477600-75-2 10 mM 312.37 S2789

155270-99-8 10 mM 384.43 S2790425637-18-9 10 mM 438.48 S2791

262352-17-0 10 mM 600.47 S2792433967-28-3 10 mM 305.32 S2795

857064-38-1 10 mM 356.22 S2796193275-84-2 10 mM 638.82 S2797

658084-64-1 10 mM 391.51 S27991035270-39-3 10 mM 463.57 S2801

1032568-63-0 10 mM 480.52 S2802851983-85-2 10 mM 388.55 S2803

410536-97-9 10 mM 394.47 S2804396129-53-6 10 mM 272.30 S2805

1257704-57-6 10 mM 462.57 S28061195765-45-7 10 mM 519.56 S2807

1001264-89-6 10 mM 458.00 S280896206-92-7 10 mM 193.24 S2809

1224844-38-5 10 mM 309.33 S281190141-22-3 10 mM 578.61 S2812

184025-19-2 10 mM 386.40 S28131217486-61-7 10 mM 441.47 S2814

148741-30-4 10 mM 316.46 S28161223001-51-1 10 mM 432.40 S2817

112522-64-2 10 mM 269.30 S2818183232-66-8 10 mM 555.24 S2819

761437-28-9 10 mM 468.94 S282048208-26-0 10 mM 334.33 S2821

865854-05-3 10 mM 334.39 S2823507475-17-4 10 mM 279.29 S2824

1222781-70-5 10 mM 313.82 S2825183321-86-0 10 mM 379.41 S2826

1222998-36-8 10 mM 607.62 S2827

681136-29-8 10 mM 365.45 S2828

481-29-8 10 mM 290.44 S2832956104-40-8 10 mM 477.43 S2840

10 mM 358.39 S2842501437-28-1 10 mM 391.42 S2843

194413-58-6 10 mM 238.28 S2845225120-65-0 10 mM 401.89 S2847

261901-57-9 10 mM 388.95 S28491187594-09-7 10 mM 371.42 S2851

57477-39-1 10 mM 230.31 S2852868540-17-4 10 mM 719.91 S2853

2854-32-2 10 mM 426.89 S2854711019-86-2 10 mM 472.67 S2855

209481-20-9 10 mM 451.99 S285677086-21-6 10 mM 221.30 S2857

1227633-49-9 10 mM 429.54 S2858928037-13-2 10 mM 633.69 S2859

162831-31-4 10 mM 412.25 S2860871362-31-1 10 mM 391.77 S2861

61350-00-3 10 mM 232.67 S2862799264-47-4 10 mM 287.34 S2863

978-62-1 10 mM 383.67 S2864155584-74-0 10 mM 262.74 S2865

178606-66-1 10 mM 309.32 S2866211555-04-3 10 mM 376.20 S2867

850649-61-5 10 mM 339.39 S2868925705-73-3 10 mM 254.25 S2870

313516-66-4 10 mM 277.66 S2871220904-83-6 10 mM 520.94 S2872

59721-29-8 10 mM 494.52 S2874179474-81-8 10 mM 367.87 S2875

121917-57-5 10 mM 337.37 S287651298-62-5 10 mM 269.69 S2877

873225-46-8 10 mM 483.63 S2882251992-66-2 10 mM 300.40 S2885

717907-75-0 10 mM 507.49 S2890504433-23-2 10 mM 275.30 S2891

1161205-04-4 10 mM 262.69 S2892607742-69-8 10 mM 353.44 S2894

10537-47-0 10 mM 282.38 S2895193000-39-4 10 mM 411.86 S2896

690206-97-4 10 mM 333.74 S2897778270-11-4 10 mM 374.32 S2899

1004316-88-4 10 mM 776.02 S2900883050-24-6 10 mM 316.35 S2901

941685-37-6 10 mM 306.37 S2902220991-20-8 10 mM 293.72 S2903

952021-60-2 10 mM 419.48 S2904459168-41-3 10 mM 277.75 S2905

355025-13-7 10 mM 488.98 S2906

53179-13-8 10 mM 185.22 S2907

133053-19-7 10 mM 442.51 S291155778-02-4 10 mM 290.36 S2912

19542-67-7 10 mM 207.25 S2913244767-67-7 10 mM 329.40 S2914

22978-25-2 10 mM 276.68 S2915349085-38-7 10 mM 355.39 S2918

931398-72-0 10 mM 352.34 S2919137975-06-5 10 mM 427.54 S2920

1390637-82-7 10 mM 456.59 S2921610798-31-7 10 mM 391.42 S2922

405060-95-9 10 mM 479.81 S2923252917-06-9 (free base) 10 mM 501.80 S2924

1186486-62-3 10 mM 638.65 S2925327036-89-5 10 mM 222.26 S2926

79183-19-0 10 mM 306.14 S2927303162-79-0 10 mM 399.51 S2928

63208-82-2 10 mM 367.30 S2929366789-02-8 10 mM 435.88 S3002

78246-49-8 10 mM 365.83 S300574711-43-6 10 mM 298.36 S3008

444731-52-6 10 mM 437.52 S3012155148-31-5 10 mM 794.47 S3013

50-78-2 10 mM 180.16 S30174394-00-7 10 mM 282.22 S3018

41621-49-2 10 mM 268.35 S3019168273-06-1 10 mM 463.79 S3021

2438-72-4 10 mM 223.27 S302384057-84-1 10 mM 256.09 S3024

329-98-6 10 mM 174.19 S302510083-24-6 10 mM 244.24 S3026

50-65-7 10 mM 327.12 S3030668270-12-0 10 mM 472.54 S3031

130641-38-2 10 mM 324.37 S3032274901-16-5 10 mM 303.40 S3033

210421-74-2 10 mM 476.89 S303423541-50-6 10 mM 563.98 S3035

81131-70-6 10 mM 446.51 S3036190786-44-8 10 mM 547.06 S3037

265121-04-8 10 mM 1004.83 S3038162011-90-7 10 mM 314.36 S3043

367514-88-3 10 mM 529.14 S3044147403-03-0 10 mM 456.45 S3046

26095-59-0 10 mM 563.57 S3047242478-38-2 10 mM 480.55 S3048

135729-62-3 10 mM 332.87 S3050157212-55-0 10 mM 569.63 S3051

182349-12-8 10 mM 532.03 S3052123524-52-7 10 mM 582.65 S3053

58066-85-6 10 mM 407.57 S3056

863031-21-4 10 mM 568.53 S3057

86347-15-1 10 mM 236.74 S306023828-92-4 10 mM 414.56 S3064

39831-55-5 10 mM 781.76 S3065357-08-4 10 mM 363.84 S3066

7491-74-9 10 mM 142.16 S307069308-37-8 10 mM 213.66 S3072

113775-47-6 10 mM 200.28 S3075269055-15-4 10 mM 435.28 S3080

126784-99-4 10 mM 475.62 S3081753498-25-8 10 mM 508.56 S3083

1508-65-2 10 mM 393.95 S3117101152-94-7 10 mM 246.35 S3140

133099-07-7 10 mM 507.46 S3144154-69-8 10 mM 291.82 S3146

130929-57-6 10 mM 305.29 S3147979-32-8 10 mM 356.50 S3149

33342-05-1 10 mM 527.63 S3151297-76-7 10 mM 384.51 S3160

132-17-2 10 mM 403.53 S3163188062-50-2 10 mM 335.35 S3165

850-52-2 10 mM 310.43 S316758579-51-4 10 mM 292.55 S3172

82248-59-7 10 mM 291.82 S31755579-84-0 10 mM 209.12 S3176

138890-62-7 10 mM 383.51 S317842835-25-6 10 mM 261.25 S3181

549-18-8 10 mM 313.86 S318362-13-5 10 mM 217.65 S3185

3978-86-7 10 mM 522.55 S318691374-20-8 10 mM 296.84 S3189

98769-84-7 10 mM 409.50 S3199322-79-2 10 mM 248.16 S3200

440-17-5 10 mM 480.42 S32012468-21-5 10 mM 336.43 S3202

59263-76-2 10 mM 269.81 S3204153439-40-8 10 mM 538.12 S3208

71320-77-9 10 mM 268.74 S3212472-15-1 10 mM 456.70 S3603

66104-23-2 10 mM 410.59 S40001140909-48-3 10 mM 635.59 S4001

654671-77-9 10 mM 523.32 S40021070-11-7 10 mM 277.23 S4004

10592-13-9 10 mM 480.90 S4005105956-97-6 10 mM 365.79 S4006

50357-45-4 10 mM 413.34 S4007100299-08-9 10 mM 266.30 S4008

223673-61-8 10 mM 396.51 S400934381-68-5 10 mM 372.89 S4010

99464-64-9 10 mM 447.46 S4011

100643-71-8 10 mM 310.82 S4012

10163-15-2 10 mM 143.95 S4013101-31-5 10 mM 289.37 S4014

11018-89-6 10 mM 728.77 S4016109-57-9 10 mM 116.18 S4017

330784-47-9 10 mM 483.95 S4019134308-13-7 10 mM 273.24 S4021

57-66-9 10 mM 285.36 S402251-05-8 10 mM 272.77 S4023

80-49-9 10 mM 370.28 S402451-56-9 10 mM 356.25 S4025

2192-20-3 10 mM 447.83 S40263717-88-2 10 mM 427.92 S4027

2392-39-4 10 mM 516.40 S4028320345-99-1 10 mM 564.55 S4031

14882-18-9 10 mM 362.09 S403262-97-5 10 mM 389.51 S4034

50-14-6 10 mM 396.65 S40357081-53-0 10 mM 432.98 S4037

61-12-1 10 mM 379.92 S4038554-57-4 10 mM 236.27 S4039

522-48-5 10 mM 236.74 S4043181695-72-7 10 mM 314.36 S4049

42924-53-8 10 mM 228.29 S405179559-97-0 10 mM 342.69 S4053

52-01-7 10 mM 416.57 S405498717-15-8 10 mM 310.86 S4058

1264-62-6 10 mM 862.05 S406067-97-0 10 mM 384.64 S4063

219861-08-2 10 mM 414.43 S406423256-50-0 10 mM 291.13 S4065

522-51-0 10 mM 527.57 S406655-97-0 10 mM 362.19 S4069

541-22-0 10 mM 418.29 S40726018-19-5 10 mM 211.15 S4073

7632-00-0 10 mM 69.00 S407413463-41-7 10 mM 317.70 S4075

318-98-9 10 mM 295.80 S407661-68-7 10 mM 241.29 S4078

274693-27-5 10 mM 522.57 S4079396-01-0 10 mM 253.26 S4080

127-56-0 10 mM 236.22 S4081846589-98-8 10 mM 232.15 S4109

50-50-0 10 mM 376.49 S4110386750-22-7 10 mM 381.46 S4112

93413-62-8 10 mM 263.38 S411356-92-8 10 mM 184.07 S4118

149676-40-4 10 mM 465.49 S411926921-17-5 10 mM 432.49 S4123

1716-12-7 10 mM 186.18 S4125

23031-32-5 10 mM 548.65 S4127

53936-56-4 10 mM 194.23 S4132540737-29-9 10 mM 504.49 S5001

162359-56-0 10 mM 343.90 S5002635318-55-7 10 mM 235.22 S6001

775304-57-9 10 mM 284.24 S6003745833-23-2 10 mM 404.30 S6005

172889-27-9 10 mM 301.77 S700819983-44-9 10 mM 211.19 S7024

550-24-3 10 mM 294.39 S70251201438-56-3 10 mM 416.86 S7028

1174043-16-3 10 mM 395.43 S7029194423-15-9 10 mM 369.22 S7039

20350-15-6 10 mM 280.36 S7046935888-69-0 10 mM 532.61 S7049

1152311-62-0 10 mM 520.50 S70591373423-53-0(free base) 10 mM 453.96 S7070

485-49-4 10 mM 367.35 S70716384-92-5 10 mM 147.13 S7072

188968-51-6 10 mM 588.66 S70771118807-13-8 10 mM 376.86 S7096

856925-71-8 10 mM 292.33 S70993690-10-6 10 mM 228.20 S7113

659730-32-2 10 mM 430.40 S7115380315-80-0 10 mM 369.48 S8000

1316214-52-4 10 mM 433.50 S80011372540-25-4 10 mM 433.42 S8002

196868-63-0 10 mM 341.79 S80031021868-92-7 10 mM 367.91 S8004

438190-29-5 10 mM 273.23 S80051392399-03-9 10 mM 600.02 S8006

1232410-49-9 10 mM 368.41 S8007118409-57-7 10 mM 186.17 S8009

866206-55-5 10 mM 517.96 S8010686347-12-6 10 mM 546.88 S8012

885101-89-3 10 mM 347.41 S80141188910-76-0 10 mM 517.46 S8015

1260141-27-2 10 mM 461.46 S80161143532-39-1 10 mM 428.92 S8019

317318-84-6 10 mM 471.49 S8020960203-27-4 10 mM 379.36 S8021

864070-44-0 10 mM 450.91 S8022301305-73-7 10 mM 360.43 S8023

146535-11-7 10 mM 266.29 S8024188591-46-0 10 mM 392.78 S8025

206873-63-4 10 mM 646.73 S802850892-23-4 10 mM 323.80 S8029

110078-46-1 10 mM 502.78 S80301177865-17-6 10 mM 530.96 S8031

1370261-97-4,1370261-96-3(fr10 mM 429.91 S8032

608141-41-9 10 mM 460.50 S8034

1246086-78-1 10 mM 422.29 S8035487-52-5 10 mM 272.25 S8036

4311-88-0 10 mM 259.33 S80371048371-03-4 10 mM 279.29 S8038

1207360-89-1 10 mM 452.55 S8040870483-87-7 10 mM 366.41 S8042

287383-59-9 10 mM 326.35 S80431257044-40-8 10 mM 868.44 S8048

441798-33-0 10 mM 588.27 S8051

Target Brief descriptionBcl-2 ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.Autophagy ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

CSF-1R Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.PARP ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

c-Kit Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.Bcr-Abl Saracatinib (AZD0530) is a Src inhibitor for c-Src and v-Abl with IC50 of 2.7 nM and 30 nM, respectively.

HIF FG-4592 is an HIF α prolyl hydroxylase inhibitor.MEK AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.

ATM/ATR BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.FGFR BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

EGFR BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.Proteasome Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM.

Src Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.VEGFR Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

c-Kit Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.EGFR CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

MEK CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.Bcr-Abl

mTOR Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM.Autophagy Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.

EGFR Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.Bcr-Abl Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

EGFR Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.TNF-alpha Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

c-Kit Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.Bcr-Abl Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM.

IGF-1R NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM.c-Kit Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

MEK PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.Autophagy PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

Autophagy Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.PDGFR Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

STF-62247 is selectively toxic and growth inhibitory to renal cells lacking VHLc-Kit Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

FLT3 Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of Flt3, PDGFRβ and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively.mTOR Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM.

HDAC Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM.VEGFR Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.

Autophagy Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM.Aurora Kinase VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.

Autophagy Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM.HSP (e.g. HSP90) Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..

HDAC MS-275 is an HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively.PKC Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.

EGFR BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.Autophagy Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

PARP Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively. E3 Ligase Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM.

c-Kit Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of

PI3K GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.

MEK SL327 is a selective inhibitor for MEK1 and MEK2 with IC50 of 0.18 μM and 0.22 μM, respectively.TGF-beta/Smad SB 431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM.

ALK PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.HSP (e.g. HSP90) NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.

c-Met PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM.Bcl-2 HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM.

PI3K ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM.GSK-3 SB 216763 is a potent and selective GSK-3α inhibitor with IC50 of 34.3 nM.

p38 MAPK SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. p38 MAPK SB 202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α and p38β with IC50 of 50 nM and 100 nM, respectively.

Akt MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively.EGFR PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM, respectively.

c-Met SU11274 is a selective Met inhibitor with IC50 of 10 nM.Hedgehog GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

FGFR Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.HDAC Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts.

PARP BSI-201 (Iniparib, SAR240550) is a PARP1 inhibitor.IGF-1R NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.

HDAC PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.IGF-1R OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.

ATM/ATR KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively.IGF-1R GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.

c-Met PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM.HDAC LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM.

HDAC JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively.BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.

PARP Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM.Aurora Kinase MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM.

c-Kit Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.MEK U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively.

Aurora Kinase ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.Raf GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.

Autophagy LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation.PDK-1 OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM.

Aurora Kinase Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.ALK TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM.

PLK BI 2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM.Phospholipase (e.g. PLA) LY315920 (Varespladib) is a potent and selective secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.

c-Met XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.c-Met SGX-523 is a selective Met inhibitor with IC50 of 4 nM.

Akt GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.c-Met JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM.

Cathepsin K Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively.CDK PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.

Akt Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.PI3K XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively.

Axl XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.mTOR Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

Bcl-2 TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

HDAC MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively.

P450 (e.g. CYP17) Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM.Sirtuin SRT1720 is a selective SIRT1 activator with EC1.5 of 0.16 μM.

E3 Ligase YM155 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor for survivin with IC50 of 0.54 nM.PARP INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM and a mediator of oxidant-induced myocyte dysfunction during reperfusion.

Aurora Kinase MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM.Aurora Kinase AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.

DHFR Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.FGFR BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.

Opioid Receptor ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM.Androgen Receptor Andarine (GTX-007) is a selective nonsteroidal androgen receptor (AR) agonist with Ki of 4 nM.

HSP (e.g. HSP90) 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.HSP (e.g. HSP90) 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.

EGFR AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively.CFTR Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

CDK SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. Hedgehog Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

Aurora Kinase AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM.Microtubule Associated Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Autophagy Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.Autophagy Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

Raf PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively.CDK Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

Aurora Kinase SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively.STAT S3I-201 (NSC 74859) is a Stat3 inhibitor with IC50 of 86 μM.

DNA/RNA Synthesis Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.Dehydrogenase MK-8245 is an inhibitor of stearoyl-CoA desaturase (SCD) which targets the liver with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1.

HSP (e.g. HSP90) Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells.Potassium Channel TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM.

HSP (e.g. HSP90) AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells.VEGFR E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively.

Microtubule Associated ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules.DNA/RNA Synthesis Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.

EGFR CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.Autophagy

PI3K TGX-221 is a potent, selective PI3K inhibitor for p110β with IC50 of 8.5 nM.EGFR WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively.

Aurora Kinase CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.E3 Ligase JNJ 26854165 (Serdemetan) is an orally bioavailable HDM2 (an E3 ligase) antagonist.

EGFR WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFRL858R and EGFRL858R/T790M with IC50 of 2 nM and 8 nM, respectively. Androgen Receptor Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM.

HSP (e.g. HSP90) BIIB021 is a novel inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectivley.MEK PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM.

c-Kit Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.EGFR WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor.

Wnt/beta-catenin XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.Aurora Kinase ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively.

HCV Protease Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM.HIV Protease Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.

Telomerase BIBR 1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM.

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinicsemialdehyde dehydrogenase.

PI3K PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively.

Aromatase Anastrozole inhibits the enzyme aromatase.Substance P Substance P antagonists (SPA).

Androgen Receptor Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM.Estrogen/progestogen ReceptoFulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM.

DNA/RNA Synthesis Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.E3 Ligase

EGFR CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.P450 (e.g. CYP17) TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively.

Aromatase Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.5-alpha Reductase Finasteride is an inhibitor of steroid Type II 5α-reductase.

Topoisomerase Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.DNA/RNA Synthesis Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

DNA Methyltransferase Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.Dimesna is an uroprotective agent used to decrease urotoxicity.

5-alpha Reductase Dutasteride is a 5-alpha-reductase inhibitor DNA-PK PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM.

Adrenergic Receptor Bisoprolol is a selective type β1 adrenergic receptor blockerc-Kit

Autophagy Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.DNA/RNA Synthesis Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS).

DHFR Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

DNA/RNA Synthesis Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.DNA/RNA Synthesis Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

DNA/RNA Synthesis Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.Epigenetic Reader Domain PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.

DNA/RNA Synthesis This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.DNA/RNA Synthesis Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase

PI3K YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM.c-Kit OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

DNA/RNA Synthesis Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers.Topoisomerase Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

DNA/RNA Synthesis Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.Topoisomerase Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

mTOR KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.Estrogen/progestogen ReceptoRaloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

Topoisomerase Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.DNA/RNA Synthesis Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Topoisomerase Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.HIF 2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

IGF-1R AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively.Aromatase Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM.

Autophagy Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer.Autophagy Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.

5-HT Receptor Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.c-Kit MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

AChR Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.Aurora Kinase JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively.

Androgen Receptor MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM.

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase

AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

Estrogen/progestogen ReceptoDienogest is an orally active synthetic progesterone (or progestin).

Sodium Channel Rufinamide, a triazole derivative, is an anticonvulsant medication.Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

P2 Receptor A novel platelet inhibitor MT Receptor Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.

CaSR AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism.COX Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.

Beta Amyloid BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.FGFR PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

mTOR WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM.Raf PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

PI3K IC-87114 is a selective inhibitor of PI3Kδ with IC50 of 0.5 μM.IκB/IKK BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively.

PDK-1 BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM.Dopamine Receptor Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

AMPA Receptor-kainate Rece Aniracetam is a nootropics and neuroprotective drug.5-HT Receptor Asenapine ihibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

RAAS Benazepril is a medication used to treat high blood pressure.AChR Biperiden is an antiparkinsonian agent of the anticholinergic type.

Topoisomerase Camptothecin (Camptohecine, 20-(S)-Camptothecin, CPT, NSC100880) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM.DNA/RNA Synthesis Carmofur (INN) is a pyrimidine analogue used as an antineoplastic agent.

Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Histamine Receptor Cetirizine Dihydrochloride is an antihistamine.

Calcium Channel Cilnidipine is a calcium channel blocker.PDE Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Microtubule Associated Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM.DNA/RNA Synthesis Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1.

DNA/RNA Synthesis Ftorafur is a substance being used in the treatment of some types of cancer.DNA/RNA Synthesis Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.

Androgen Receptor Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.DNA/RNA Synthesis Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

PKC A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM.LPA Receptor Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.

c-Met AMG-208 is a highly selective c-Met inhibitor with IC50 of 9.3 nM.Telomerase Costunolide inhibits FPTase with IC50 of 20 μM and also inhibits telomerase with IC50 of 90 μM and 65 μM in MCF-7 and MDA-MB-231 cells.

Autophagy Dexamethasone is an anti-inflammatory and immunosuppressant.Adrenergic Receptor Doxazosin mesylate is an alpha-1 adrenergic receptor blocker.

Topoisomerase Ellagic acid has antiproliferative and antioxidant property.COX Etodolac (Lodine) is a COX inhibitor with an IC50 of 53.5 nM.

GABA Receptor Etomidate is a GABAA receptors agonist at GABAA receptors.GABA Receptor Flumazenil is a benzodiazepine antagonist.

5-HT Receptor Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.DNA/RNA Synthesis Flupirtine maleate is the salt form of Flupirtine, which is a non-opioid, centrally acting analgesia, muscle relaxation and neuroprotection.

5-HT Receptor Fluvoxamine maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI).GABA Receptor Gabapentin Hydrochloride is a GABA analogue.

AChR Galanthamine (Razadyne, Reminyl) is an AChE inhibitor with IC50 of 14 nM.Topoisomerase Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

DPP-4 Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.5-HT Receptor Granisetron HCl is a serotonin 5-HT3 receptor antagonist

PI3K TG100-115 is a potent and dual selective inhibitor for PI3Kγ and PI3Kδ with IC50 of 83 nM and 235 nM, respectively.

P450 (e.g. CYP17) Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively.

Proton Pump Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.Histamine Receptor Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Histamine Receptor Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.RAAS Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

mTOR GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively.c-Met MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM and 7 nM, respectively.

PLK Rigosertib (Estybon, Novonex, ON-01910) is a non-ATP-competitive inhibitor of PLK1 (Polo-like kinase 1) with IC50 of 9 nM.c-Kit Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

Microtubule Associated Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.Integrase BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM.

Topoisomerase Amonafide (NSC-308847) is a selective topoisomerase II inhibitor.Carbonic Anhydrase Dorzolamide HCl is a carbonic anhydrase inhibitor.

Estrogen/progestogen ReceptoGestodene is a progestogen hormonal contraceptive.Estrogen/progestogen ReceptoDrospirenone is a synthetic progestin that is an analog to spironolactone.

JAK INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.Hydroxylase It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

HIV Protease Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM.Histamine Receptor Mianserin is a psychoactive agent of the tetracyclic antidepressant.

Lysyl Hydroxylase Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth.DNA/RNA Synthesis Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.

5-HT Receptor Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.Proteasome Nafamostat is an anticoagulant.

Adrenergic Receptor Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.Autophagy Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.

5-HT Receptor Ondansetron is a serotonin 5-HT3 receptor antagonist. Sodium Channel Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

EGFR Pelitinib (EKB-569) is a potent EGFR inhibitor with IC50 of 38.5 nM.Autophagy Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

AChR Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant.Reverse Transcriptase Stavudine is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

Reverse Transcriptase Tenofovir disoproxil fumarate belongs to nucleotide analogue reverse transcriptase inhibitors (nRTIs). Reverse Transcriptase Tenofovir blocks reverse transcriptase and hepatitis B virus infections.

Dehydrogenase Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.Adrenergic Receptor Alfuzosin(Uroxatral) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

PI3K AS-605240 is a novel, potent and selective PI3Kγ inhibitor with IC50 of 8 nM.P2 Receptor Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent.

PKC Staurosporine (AM-2282) is a potent PKC inhibitor with IC50 of 2.7 nM.HDAC Droxinostat (CMH, 5809354) is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively.

Calcium Channel Ranolazine(Ranexa), is an antianginal medication.Potassium Channel Repaglinide is for the treatment of type II diabetes.

PDE Rolipram is a PDE4-inhibitor and an anti-inflammatory agent.PDE Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

5-HT Receptor Sumatriptan succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.5-HT Receptor Tianeptine is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes.

Adrenergic Receptor Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Carbonic Anhydrase Topiramate is an anticonvulsant compound.

AChR Varenicline is a prescription medication used to treat smoking addiction.5-HT Receptor Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).

P450 (e.g. CYP17) Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.

Zileuton (ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Aurora Kinase Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM.Kinesin Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.

Transferase Tipifarnib (Zarnestra, R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM.Aurora Kinase PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, repectively.

PDE Cilomilast (SB-207499) is a potent LPDE4 and HPDE4 inhibitor with IC50 of 100 nM and 120 nM, respectively.Endothelin Receptor Zibotentan (ZD4054) is a specific Endothelin A (ETA) antagonist with IC50 of 21 nM.

HIV Protease Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM.ROCK Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of ~0.5 μM.

JNK SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.Topoisomerase Ofloxacin is a synthetic broad-spectrum antimicrobial agent.

Topoisomerase Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent.Alfacalcidol is a non-selective VDR activator medication.

FGFR TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.MAO Safinamide Mesylate is mesylate salt of Safinamide, which selectively and reversibly inhibits MAO-B with IC50 of 0.45 μM.

ROCK GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.MEK AS703026 is a highly selective and potent non-competitive inhibitor of MEK1/2 with IC50 of 5-11 nM.

TGF-beta/Smad SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM.ATPase

HCV Protease VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM.P-gp LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with Ki of 60 nM.

HCV Protease BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM.HDAC MC1568 is a selective HDAC inhibitor with IC50 of 220 nM.

PLK HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk)1 with IC50 of 118 nM.EGFR AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively.

CDK PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.5-HT Receptor Naratriptan (Amerge) is a triptan agent that is used for the treatment of migraine headaches.

PI3K PIK-93 is a novel and potent inhibitor of PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively.Bcr-Abl AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

DNA/RNA Synthesis Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor.p38 MAPK LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM.

DHFR Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.HSP (e.g. HSP90) NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM.

Dehydrogenase Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.PDE Dyphylline(Dilor, Lufyllin, diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects.

RAAS Perindopril Erbumine (Aceon) is a potent ACE) inhibitor with IC50 of 1.05 nM.RAAS Irbesartan (Avapro, SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

PDE Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM.HDAC SB939 is a potent HDAC inhibitor with IC50 of 40-140 nM.

COX Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug.Aurora Kinase CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.

Aminopeptidase CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively.mTOR XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.

CDK AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.Wee1 MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM.

FLT3 AC220 (Quizartinib) is a potent and selective inhibitor of Flt3ITD and Fltwt with IC50 of 1.1 nM and 4.2 nM, respectively.Beta Amyloid LY2811376 is a non-peptidic BACE1 inhibitor with IC50 of 239 nM/249 nM and also decreases the Aβ secretion with EC50 of ~300 nM.

Aurora Kinase Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively.MEK BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM.

MEK BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

Oligomycin A is a specific inhibitor of complex V (ATP synthase) of the electron transport chain.

Chk AZD7762 is a novel CHK1 and CHK2 inhibitor with IC50 of 5 nM and <10 nM, respectively.

Syk R406 (free base) is a Syk inhibitor with IC50 of 41 nM.PDGFR CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.

VDA DMXAA (ASA404) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively.HCV Protease Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.

DPP-4 Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.Sirtuin EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM.

Cannabinoid Receptor AM-1241 is a selective CB2 agonist with Ki of 3.4 nM.OX Receptor SB-408124 (Tocris-1963) is a non-peptide antagonist for OX1 with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively.

SGLT Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM.Adrenergic Receptor Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

PDE Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.mTOR AZD8055 is a novel ATP-competitive inhibitor of mTOR with IC50 of 0.8 nM.

Akt PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.PDGFR KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

Akt AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and S6K with IC50 of 32 nM/17 n/47 nM and 85 nM, respectively.Axl BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively.

CFTR VX-809 is a CFTR modulator with EC50 of 0.1 μM.TNF-alpha Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM.

MEK PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor.ATM/ATR KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.

CDK BS-181 is a highly selective CDK inhibitor for CDK7 with IC50 of 21 nM.Autophagy Fasudil is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.

p38 MAPK BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM.Tie-2 Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM.

RAAS Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.CDK PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC50 of 11 nM and 16 nM, respectively.

PKA H 89 2HCl is a mutiple-targeted inhibitor for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b with IC50 of 80 nM, 120 nM, 135 nM, 270 nM, 2600 nM and 2800 nM, respectively. GSK-3 TWS119 is a GSK-3β inhibitor with IC50 of 30 nM.

Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells.Factor Xa Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

Gamma-secretase Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.RAAS Olmesartan medoxomil (Benicar) is a compound which is hydrolyzed to olmesartan that is a selective AT1 subtype angiotensin II receptor antagonist.

5-HT Receptor Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.AChR Pyridostigmine Bromide(Mestinon) is a parasympathomimetic and a reversible cholinesterase inhibitor.

Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.Adrenergic Receptor Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity.

Sodium Channel Riluzole(Rilutek) is a drug used to treat amyotrophic lateral sclerosis. 5-HT Receptor Risperidone(Risperdal) is an atypical antipsychotic used to treat schizophrenia.

AChR Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Alendronate (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.

COX Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.OX Receptor Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

Allopurinol Sodium(Aloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 µM for CYP2C9)

COX Ibuprofen (Advil, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.HIV Protease Amprenavir is a HIV protease inhibitor with IC50 of 14.6 ng/mL in wild-type HIV isolates.

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

COX Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

COX Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.DNA/RNA Synthesis Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.

5-HT Receptor Zolmitriptan(Zomig) is a selective serotonin receptor agonist.RAAS Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

Calcium Channel Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.Estrogen/progestogen ReceptoEstrone is an estrogenic hormone.

Flucytosine (5-Fluorocytosine, 5-FC, Ancobon) is an antifungal drug with IC50 of 0.93 μM in C. albicans.Aromatase Aminoglutethimide (AMG, Cytadren) is an aromatase inhibitor with IC50 of 10 μM.

PDE Aminophylline(Phyllocontin, Truphylline) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.Autophagy Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.

Torsemide(Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ± 0.17 μM.Reverse Transcriptase Didanosine(Videx, Videx EC) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

Autophagy Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form.Reverse Transcriptase Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.

Reverse Transcriptase Lamivudine(Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.

COX Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM.Autophagy Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites.

Reverse Transcriptase Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Reverse Transcriptase Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

Dopamine Receptor Paliperidone(Invega) is an atypical antipsychotic.RAAS Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Reverse Transcriptase Nevirapine(Viramune) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.Proton Pump Esomeprazole magnesium(Nexium) is a proton pump inhibitor to reduce gastric acid secretion.

Autophagy Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

AChR Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.Dopamine Receptor Quetiapine fumarate(Seroquel) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

Dopamine Receptor Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.DNA Methyltransferase Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

Estrogen/progestogen ReceptoToremifene Citrate(Fareston, Acapodene) is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.DNA Methyltransferase Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.

Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.Simvastatin (Zocor) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .

RAAS Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.Histamine Receptor Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 μM.

AMPK Acadesine results in accumulation of ZMP, which mimics both activating effects of AMP on AMPK and AMPKK.AChR The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.

Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action.Calcium Channel Amlodipine (Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.

Histamine Receptor Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.Adrenergic Receptor Betaxolol hydrochloride (Betoptic) is a β1 adrenergic receptor blocker with IC50 of 6 μM.

Sodium Channel Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.Pranlukast is a selective cysteinyl leukotriene receptor antagonist.

Adrenergic Receptor Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

Autophagy

Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.

Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.

Azithromycin (Zithromax) is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.Flubendazole (Flutelmium) is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM.

Histamine Receptor Cimetidine(Tagamet), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Histamine Receptor Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

Adrenergic Receptor

5-HT Receptor Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor.

Histamine ReceptorCalcium Channel Felodipine (Plendil) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

Histamine Receptor Nizatidine is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE.Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

RAAS Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 μM5-HT Receptor Tropisetron hydrochloride is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

COX Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Calcium Channel Amlodipine(Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.

P450 (e.g. CYP17) Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer.HMG-CoA Reductase Fluvastatin sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM.

AChREstrogen/progestogen ReceptoPregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 ¦ÌM and 6.0 ¦ÌM, respectively.

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.AChR Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

Opioid Receptor Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.Autophagy Metformin hydrochloride(Glucophage) is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.

COX

GABA Receptor Nefiracetam (Translon) is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.Potassium Channel Nicorandil(Ikorel) is potassium channel activator.

Autophagy Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL.

5-HT ReceptorAChR Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker.

AutophagyDNA/RNA Synthesis Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

DNA/RNA Synthesis Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.DNA/RNA Synthesis Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

P2 Receptor Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.Calcium Channel Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker.

DNA/RNA Synthesis Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.5-HT Receptor Ondansetron (Zofran) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

ATPase Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.Integrase Elvitegravir (EVG, JTK-303/GS-9137) is a HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

CCR5 Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively.Integrase Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectivly.

DHFR Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.Dopamine Receptor Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.

HDAC PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM.FAK PF 573228 is a inhibitor of FAK with IC50 of 4 nM.

CDK BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively.Suplatast tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.

Aurora Kinase ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively.

Bifonazole is an antifungal agent and a prostatic aromatase activity inhibitor with IC50 of 1.6 μM.

Metoprolol tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 μM.

Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM.Pranoprofen is a PGE2 inhibitor with IC50 of 7.5 μM.

Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

Adrenergic Receptor Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively.

Histamine Receptor Ketotifen fumarate (Zaditor) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.5-HT Receptor Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.

GABA ReceptorDNA/RNA Synthesis

Calcium Channel

RAAS Candesartan cilexetil (Atacand) is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg

Adrenergic ReceptorCOX

Androgen Receptor Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM.AMPA Receptor-kainate Rece

Histamine Receptor

P450 (e.g. CYP17)COX

Calcium ChannelRAAS

AChRDehydrogenase

Adrenergic ReceptorHMG-CoA Reductase

Histamine Receptor

Potassium Channel

PPARRAAS

HMG-CoA ReductaseHistamine Receptor

RAASCalcium Channel

RAAS

5-HT ReceptorOpioid Receptor

Adrenergic ReceptorAChR

Adrenergic ReceptorAdrenergic Receptor

Adrenergic ReceptorRAAS

5-HT Receptor

RAAS

Proteasome Gabexate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.MAO

Opioid Receptor

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.

Phentolamine mesilate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM.Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

Memantine hydrochloride (Namenda) is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Cyproheptadine hydrochloride (Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.Lornoxicam (Xefo) is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

Strontium ranelate (Protelos) is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.Captopril (Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

Orphenadrine citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Hytrin (terazosin) is an alpha-adrenergic blocker used to treat high blood pressure and enlarged prostate.Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

Ozagrel hydrochloride is a selective thromboxane A2 synthetase enzyme inhibitors with IC50 of 11 nM, used as antiasthmatic agent.Mitiglinide is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Atorvastatin (Lipitor) is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 ¦ÌM, which is used for the treatment of hypertension and congestive heart failure.Cleviprex (Clevidipine) is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure.

Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.Adiphenine is a nicotinic receptor inhibitor with IC50 of 15 ¦ÌM, used as an antispasmodic drug.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.Rivastigmine, a cholinesterase inhibitor with IC50 of 5.5 μM, ues as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.

Dexmedetomidine is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.Fosinopril sodium (Monopril) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).

Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

Rasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

Naltrexone is an opioid receptor antagonist with IC50 of 8 nM used primarily in the management of alcohol dependence and opioid dependence.

Dopamine Receptor

5-HT ReceptorHistamine Receptor

COXSodium Channel

EGFR Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.5-HT Receptor

Adrenergic ReceptorSodium Channel

Adrenergic Receptor Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.PDE S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM.

Estrogen/progestogen ReceptoBazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM.AChR Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.

PDE Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.GABA Receptor Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analogue.

MEK AZD8330 (ARRY-424704) is a MEK 1/2 inhibitor with IC50 of 7 nM.GPR GSK-1292263 is a novel GPR119 agonist.

EGFR Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.Smoothened LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

5-alpha Reductase CGS 21680 hydrochloride is an A2A adenosine receptor agonist with an Ki of 27 nM.BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.

LY2608204 activates glucokinase (GK) with EC50 of 42 nM.LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.

Hedgehog LY2940680 binds to the Smo receptor and potently inhibits Hh signaling.Aurora Kinase KW-2449 potently inhibits Flt3, Abl and Aurora A with IC50 of 6.6 nM, 14 nM and 48 nM, respectively.

Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoformsS6 Kinase PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM.

Dopamine Receptor PD 128907 HCl is a potent and selective dopamine D2/D3 receptors agonist.RAAS Rosuvastatin calcium is an competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

HDAC ITF2357 (Givinostat) is a potent inhibitor of HDAC with IC50 of 7.5-16 nM.PARP AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM.

JAK LY2784544 is selective to V617F mutant JAK2 with IC50 of 55 nM in Ba/F3 cells.Proteasome MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.

Proteasome MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. Kinesin SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively.

FGFR BGJ398 (NVP-BGJ398) is a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM, respectively.EGFR AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively.

TGF-beta/Smad SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively.P450 (e.g. CYP17) Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.

EGFR AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, respectively.PLK GSK461364 inhibits purified Plk1 with Ki of 2 nM.

FLT3 R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.Pim SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively.

RAAS Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.c-Met BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively.

Bcr-Abl NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively.EGFR OSI-420 is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for inhibition of human EGFR and EGFR autophosphorylation with IC50 of 2 nM and 20 nM, respectively.

Syk R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.PI3K PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively.

Aromatase Formestane(Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM.

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Flunixin meglumine is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity. Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.

Cisatracurium besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Microtubule Associated Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.

JAK AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, respectively.Beta Amyloid DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

HER2 Mubritinib (TAK 165) is a potent inhibitor of ErbB2 with IC50 of 6 nM.Topoisomerase Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.

Autophagy PP242 is a selective mTOR inhibitor with IC50 of 8 nM.JAK CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.

Raf SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM.VEGFR Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM.

APC Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor and also inhibits an E3 ubiquitin ligase called "anaphase-promoting complex/cyclosome (APC/C)".PI3K CAL-101 is a selective PI3K class I inhibitor of p110δ with IC50 of 2.5 nM.

PI3K PIK-294 is a highly potent and selective p110δ inhibitor with IC50 of 10 nM.Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current.

TGF-beta/Smad LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM.c-Kit Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRβ with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.

5-HT Receptor Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.ATPase Esomeprazole sodium (Nexium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

PLK BI6727 (Volasertib) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM.mTOR Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively.

AChR Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.Bcr-Abl WP1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

HDAC AR-42 (HDAC-42, OSU-HDAC42) is a pan-HDAC inhibitor with IC50 30 nM.ATM/ATR CP-466722 is an potent and reversible ATM inhibitor.

P450 (e.g. CYP17) Abiraterone acetate (CB7630, CB 7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.PI3K BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively.

PKC CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM.GluR (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM.

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

P450 (e.g. CYP17) Apigenin is a potent P450 inhibitor for CYP2C9 with IC50 of 23 pMArbutin(Uvasol, p-Arbutin) is a tyrosinase inhibitor with an IC50 of 1.09 mM.

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.p38 MAPK Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.

P450 (e.g. CYP17) Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.

STAT Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM.Cytisine is a nicotinic acetylcholine receptor agonist.

Histamine Receptor Hesperetin is a bioflavonoid and, to be more specific, a flavanone.Akt Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway.

PDE Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively.PDE Luteolin is a PDE4 inhibitor and a general phosphodiesterase inhibitor, and an Interleukin 6 inhibitor.

Opioid Receptor Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.

E3 Ligase Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.Puerarin (Kakonein) is a 5-HT2C receptor and benzodiazepine site antagonist.

Aminoglutethimide (Cytadren) is an anti-steroid drug which inhibits aromatase.Androgen Receptor Synephrine (Oxedrine) is a compound commonly used for weight loss.

5-Hydroxytryptophan(5-HTP) is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of Vitamin B6.Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 μM for HeLaS3 cells

Dioscin(Collettiside III) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.

GSK-3 Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM.

PI3K Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. P450 (e.g. CYP17) Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

Salidroside (Rhodioloside; Rhodosin) is a glucoside compound with an IC50 of 4.99 ± 0.23 μg/mL for the proliferation of SACC-2 cells.P450 (e.g. CYP17) Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge.

Calcium Channel Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM.EGFR Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.

TGF-beta/Smad Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. 20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.

Topoisomerase 10-Hydroxycamptothecin (10-HCPT, 10-hydroxy-CPT, OHCPT, NSC107124) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

Calcium Channel Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.Adrenergic Receptor Synephrine HCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

Potassium Channel Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM.cAMP Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC).

Estrogen/progestogen ReceptoEquol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines.Dopamine Receptor Amantadine hydrochloride(Symmetrel) is used to treat or prevent infections of the respiratory tract caused by a certain virus.

Dopamine Receptor Amfebutamone (Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectivelyDopamine Receptor Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

cAMP Bupivacaine hydrochloride(Marcain) is a more potent cAMP production inhibitor with an IC50 of 2.3 μMAChR Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

Dopamine Receptor Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currentsAdrenergic Receptor Clonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

5-HT Receptor Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.Dopamine Receptor Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Dopamine Receptor Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.AChR Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.

Estrogen/progestogen ReceptoEstriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.Fluocinolone(Flucort-N) acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.

AChR Gallamine triethiodide(Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.Estrogen/progestogen ReceptoHexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

PDGFR Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.Autophagy Loperamide is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.

Calcium Channel Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.Calcium Channel Manidipine HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

ATPase Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDEMitoxantrone HCl is a classic folic acid antagonist.

Potassium Channel Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.AChR Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor.

Autophagy Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.5-HT Receptor Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

Histamine Receptor Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamineAdrenergic Receptor Oxymetazoline hydrochloride is an α1 and α2 adrenergic receptor agonist.

Factor Xa Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.AChR Pancuronium (Pavulon) is a competitive acetylcholine antagonist with an IC50 of 5.5 ¡À 0.5 nM

Adrenergic Receptor Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.Sodium Channel Propafenone(Rytmonorm) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

Opioid Receptor Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μMPPAR Rosiglitazone maleate (Avandia) is an anti-diabetic agent in the thiazolidinedione class of agents.

Adrenergic Receptor Salbutamol (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

AChR Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ¡À 4.3 nM

Adrenergic Receptor Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μMSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax

Tenoxicam(Mobiflex) is a good HO. radicals scavenger with an IC50 of 56.7 μMPDE Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

Adrenergic Receptor Xylazine HCl is α2 class of adrenergic receptor agonist.Adrenergic Receptor Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

Adrenergic Receptor Naphazoline hydrochloride (Naphcon) is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Adrenergic Receptor Epinephrine bitartrate (D02149, Adrenalinium) is alpha- and beta-adrenergic receptor stimulator.

Adrenergic Receptor L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines.Adrenergic Receptor DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

Sodium Channel Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer.Sodium Channel Phenytoin (Lepitoin; NSC 8722; Phenytek; Phenytoine; Sodanton; Zentropi) is an inactive voltage-gated sodium channel stabilizer.

P450 (e.g. CYP17) Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively.Dopamine Receptor Dopamine hydrochloride (Inotropin) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

COX Asaraldehyde (Asaronaldehyde) is natural COX-2 inhibitor.Adrenergic Receptor Ritodrine hydrochloride (DU 21220; Miolene; NSC 291565; Pre-Par) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.

5-HT Receptor Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. AMPK Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class.

Adrenergic ReceptorAChR Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.

AChR Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist.

AChR Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.Histamine Receptor Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist.

DNA/RNA Synthesis Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively.P450 (e.g. CYP17) Clarithromycin (Biaxin, Klacid) is a macrolide antibiotic and a CYP3A4 substrate and inhibitor.

PPAR Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively.Sodium Channel Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker.

Estrogen/progestogen ReceptoClomifene citrate (Serophene) is a selective estrogen receptor modulator.Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

Adrenergic ReceptorEstrogen/progestogen ReceptoMedroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Adrenergic Receptor Phenylephrine hydrochloride is a selective α1-adrenergic receptor agonist.Calcium Channel Tetracaine hydrochloride (Pontocaine) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

COX Phenacetin is a non-opioid analgesic without anti-inflammatory properties.Reverse Transcriptase Zidovudine (Retrovir) is a reverse transcriptase inhibitor.

RAAS Quinapril hydrochloride (Accupril) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.5-HT Receptor

Histamine Receptor Brompheniramine is a histamine H1 receptors antagonist.Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.

Vasopressin Receptor Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28¦ÌM for the inhibition of AVP-induced platelet aggregation.Potassium Channel Gliclazide (Diamicron) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ¡À 30 nM

COX Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Carbonic Anhydrase Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.

Androgen Receptor Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone.Estrogen/progestogen ReceptoMifepristone (Mifeprex, RU-486, RU-38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

Lonidamine is an orally administered small molecule hexokinase inactivator with an IC50 of 0.85 mM.Estrogen/progestogen Recepto

AChR Arecoline is a muscarinic acetylcholine receptor agonist.

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

Scopine HCl is the hydrochloride of Scopine, which is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

Isoprenaline is a non-selective β-adrenoceptor, inhibits the 3H-inositol phosphate accumulation with IC50 of 0.08 μM.

Trazodone is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

MEK TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM. TGF-beta/Smad LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.

PDE GSK256066 is a selective PDE4B inhibitor with IC50 of 3.2 pM.CDK AZD5438 is a potent inhibitor of CDK1, CDK2 and CDK9 with IC50 of 16 nM, 6 nM, and 20 nM, respectively.

DNA-PK PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM.mTOR OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.

Syk R788 (Fostamatinib) is a Syk inhibitor with IC50 of 41 nM.Chk LY2603618 (IC-83) is a selective Chk1 inhibitor with potential anti-tumor activity.

HDAC Tubastatin A is a potent HDAC6 inhibitor with IC50 of 15 nM.mTOR PKI-587 is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively.

AChR PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM in α7*-expressing SH-EP1 cells.Liver X Receptor GW3965 is a potent, selective LXR agonist, which exhibits its potency in the LXRα/SRC1 LiSA and LXRα-GAL4 with EC50 of 125 nM and 190 nM, respectively.

FAAH URB597 (KDS-4103) is a potent FAAH inhibitor with IC50 of 4.6 nM.gp120/CD4 BMS-806 (BMS 378806) selectively inhibitis the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.

Bcr-Abl DCC-2036 is a conformational control inhibitor of Abl1 and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, respectively.Akt CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.

PI3K A66 is a potent and specific p110α inhibitor with IC50 of 32 nM.GPR TAK-875 is a selective GPR40 agonist with EC50 of 14 nM.

DNA-PK NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.HSP (e.g. HSP90) SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, respectively.

HSP (e.g. HSP90) PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and also inhibits Her-2 degradation with IC50 of 37 nM.mTOR GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.

AChR 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.Beta Amyloid MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells.

mTOR WYE-125132 is a highly potent, ATP-competitive and specific mTOR inhibitor with IC50 of 0.19 nM.5-HT Receptor WAY 100635 is a potent and selective 5-HT agonist with IC50 of 0.95 nM.

RAAS Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM.PPAR Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

FAAH PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM.Integrase S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM.

mTOR WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.5-HT Receptor LY310762 is a 5-HT1D antagonist with Ki of ~0.2 μM.

Akt A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively.PI3K AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM.

FAK PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. MEK GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

Transferase A 922500 is a DGAT-1 inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively.5-HT Receptor BRL-15572 is a 5-HT1D antagonist with pKi of 7.9.

DNA/RNA Synthesis NSC-207895 suppresses MDMX with IC50 of 2.5 ¦ÌM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulate MDM2, an E3 ligaseCDK Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.

BTK PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.PI3K AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM.

PI3K CAY10505 is a PI3Kγ inhibitor with IC50 of 30 nM.Chk CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM.

DNA/RNA Synthesis CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. HSP (e.g. HSP90) KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.

JAK NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM.CDK R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively.

mTOR WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.

GluR ADX47273 is a potent and specific mGlu5 antagonist with IC50 of 0.17μM.

5-HT Receptor BMY 7378 is a multiple inhibitors of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively.c-RET TG101209 is a potent inhibitor of JAK2, Flt3 and RET with IC50 of 6 nM, 25 nM and 17 nM, respectively.

FXR WAY-362450 is a potent, selective FXR agonist with EC50 of 4 nM.mTOR GDC-0980 (RG7422) is a potent, selective inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 5 nM, 27 nM, 7 nM, and 14 nM, and also a mTOR inhibitor with Ki of 17 nM.

AMPK A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM and inhibits fatty acid synthesis with IC50 of 3.2 μM.5-HT Receptor RS-127445 is a selective 5-HT2B antagonist with pKi of 9.5 and pIC50 of 10.4.

mTOR CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM.Src KX2-391 (KX01) is a highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines .

ALK GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectivelyTGF-beta/Smad LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively.

Gamma-secretase YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively.Autophagy Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM.

Gamma-secretase LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM and 0.082 nM for membrane- and cell-based γ-secretase.Phosphorylase CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM.

Aurora Kinase TAK-901 is a novel inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM, respectively.Aurora Kinase AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively.

Raf ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM.Calcium Channel Nilvadipine (ARC029) is a potent calcium channel blocker with an IC50 of 0.03 nM.

Opioid Receptor JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM.Aurora Kinase PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively.

p38 MAPK PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM.EGFR PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

EGFR AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM.GSK-3 SB 415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively.

PDGFR Crenolanib (CP-868596) is a potent and selective inihibitor of PDGFRα with IC50 of 10 nM in PDGFRα over-expressed CHO cells.Kinesin AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.

JAK TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM.Caspase PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

PI3K PKI-402 is a potent dual PI3K/mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR with IC50 of 2 nM, 7 nM, 16 nM, 14 nM, and 3 nM, respectively.Aurora Kinase GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM, respectively.

CDK PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Akt PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM.

Aurora Kinase CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively.GSK-3 CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively.

Raf AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively. c-Met AMG 458 is a potent c-Met inhibitor of human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM.

CETP Anacetrapib (MK0859) is a potent and selective rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, respectivelymTOR NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM.

TGF-beta/Smad GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM.CDK PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with IC50 of 45 nM.

EGFR ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM. E3 Ligase AT-406 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

EGFR ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.ATM/ATR Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM

HDAC PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.SGLT Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.

c-Met NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.ALK CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM.

Integrase MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.

Autophagy 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation.

CDK Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.c-Kit Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.

Aurora Kinase MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM.CETP Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM.

TRPV SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells. c-Met MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively.

Autophagy Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.Dehydrogenase CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.

Smoothened PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively.Cannabinoid Receptor GW842166X is a potent and highly selective agonist of CB2 receptor.

HDAC M344 is a potent HDAC inhibitor with IC50 of 100 nM.E3 Ligase RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells, and also inhibits MDM2-p53 interaction by targeting to p53.

FXR GW 4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM.mTOR AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.

EGFR TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively.Sodium Channel A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM.

c-Met INCB28060 is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM.JAK CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM.

Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM.PKC Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM.

CETP Torcetrapib (CP-529414) is a CETP inhibitor with IC50 of 37 nM.GluR VU0357121 is a novel allosteric modulator of mGlu5 with EC50 of 33 nM.

JAK WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells .Transferase Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

APO866 effectively inhibits NAMPT with IC50 of 0.09 nM.FGFR AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively.

PI3K BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα and PI3Kβ with IC50 of 0.469 nM and 3.72 nM, respectively.Androgen Receptor Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively.

Sirtuin Sirtinol is a specific SIRT1 and SIRT2 inhibtor with IC50 of 131 μM and 38 μM, respectively.TGF-beta/Smad LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM.

JAK CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM.Raf Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively.

Akt GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively.GluR MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM.

mTOR INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM.Bcl-2 AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

Histamine Receptor Ciproxifan is a highly potent and selective H3-receptor antagonist with IC50 of 9.2 nM.PI3K BYL719 strongly and selectively inhibits PI3Kα.

HER2 AG879 inhibits both ErbB2 and Flk-1 with IC50 of 1 μM.ATM/ATR Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

HDAC CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.Cannabinoid Receptor AM251 is a cannabinoid 1 receptor antagonist with IC50 of 8.9 μM.

FAK NVP-TAE226, a potent dual FAK/IGF-1R, inhibiting FAK and IGF-1R with IC50 of 5.5 nM and 0.14 μM, respectively.DNA Methyltransferase RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM.

GSK-3 Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM.IκB/IKK TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.

Potassium Channel ML133 is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5).EGFR Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM.

Autophagy Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.

FAAH JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human).

Estrogen/progestogen ReceptoEpiandrosterone (3β-androsterone) is a steroid hormone with weak androgenic activity which acts as a L-type Ca2+ channel antagonist.Adrenergic Receptor ARN-509 is a selective androgen receptor inhibitor with IC50 of 16 nM.

VEGFR SAR131675 is a VEGFR-3 inhibitor with IC50 of 20 nM.S6 Kinase BI-D1870 is an ATP-competitive inhibitor of ribosomal S6 for RSK1, RSK2, RSK3 and RSK4 with IC50 of 31 nM, 24 nM, 18 nM and 15 nM, respectively.

VEGFR Semaxanib (SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor with IC50 of 1.04 μM.Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

5-HT Receptor SB-269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3.JAK Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.

5-HT Receptor BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively.Proteasome Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.

Cannabinoid Receptor BML-190 is a selective CB2 inverse agonist with Ki of 435 nM.P2 Receptor MRS2578 is a potent P2Y6 receptor with IC50 of 37 nM.

5-HT Receptor SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.GluR Dizocilpine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

StemRegenin 1 is an AhR inhibitor with IC50 of 127 nM.c-Met E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively.

5-HT Receptor IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.GluR CTEP is a selective allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM.

GluR VU 0364770 is a selective positive allosteric mGlu4 with EC50 of 1.1 μM.NOD1 ML130 is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM.

IκB/IKK IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NFκβ pathway.5-HT Receptor VUF10166 is a novel, potent and competitive antagonist to 5-HT3A with Ki of 0.04 nM.

Carbonic Anhydrase U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with IC50 of 45.1 nM and 4.5 nM, respectively.EGFR WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.

DPP-4 Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of < 10 nM.PI3K TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.

PPAR T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM.Raf GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM.

HCV Protease Camostat is a trypsin-like protease inhibitor, inhibiting matriptase and human neutrophil elastase with IC50 of 0.5 μM and 0.2 μM, respectively.5-HT Receptor Prucalopride is a selective, high affinity 5-HT receptor agonistfor 5-HT4a and 5-HT4b with Ki of 2.5 nM and 8 nM, respectively.

GluR MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.

IκB/IKK IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

FAK PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.Trk receptor GW 441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM.

GluR5-HT Receptor SB-742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63.

EGFR SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.VEGFR ZM-323881 is a potent and selective inhibitor of VEGFR2 with IC50 < 2 nM.

VEGFR ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively.Bcr-Abl GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM.

P450 (e.g. CYP17) Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

JAK S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively.COX Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of 0.06 μM.

Chk PF 477736 is a ChK inhibitor against ChK1, ChK2, VEGFR2, Yes and Fms with IC50 of 0.49 nM, 47 nM, 8 nM, 14 nM and 10 nM, respectively.Histamine Receptor JNJ-7777120 is a potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM.

LPA Receptor Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively.

VU 0361737 is a selective positive allosteric modulator for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively.

TGF-beta/Smad Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.

PKC Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.CXCR WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

E2 conjugating Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).Reverse Transcriptase Dapivirine is an nonnucleoside reverse transcriptase inhibitor for HIV reverse transcriptase with IC50 of 24 nM.

PPAR GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

HIF IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.Vasopressin Receptor Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.

P450 (e.g. CYP17) PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM. EGFR Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM.

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.GSK-3 CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

CETP LY2484595 is a potent and selective inhibitor of CETP with IC50 of 5.5 nM.GSK-3 TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.

Caspase Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.p38 MAPK TAK 715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM.

Autophagy Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.Factor Xa Rivaroxaban (Xarelto, BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM, respectively.

5-HT ReceptorCOX

c-Kit Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. CXCR Plerixafor 8HCl (DB06809, Mozobil, AMD3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

Proteasome Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.GABA Receptor

ATPase Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.Cannabinoid Receptor Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.

COX Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.Sodium Channel Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, respectively.

PMSF (Phenylmethyl sulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.Syk Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM.

Autophagy Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM.DPP-4 Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.DPP-4 Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

Endothelin Receptor Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.Telomerase Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

HMG-CoA Reductase Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Histamine Receptor Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.COX Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM.

Dopamine Receptor Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.RAAS Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.

AChR Otilonium bromide is an antimuscarinic.AChR Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.

5-HT Receptor Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.Endothelin Receptor Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

Histamine Receptor Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 and 102 nM, respectively.Calcium Channel Azelnidipine is a dihydropyridine calcium channel blocker.

Akt Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa.

Paroxetine is an antidepressant drug of the SSRI type. Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

RAAS

Adrenergic ReceptorSodium Channel Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, respectively.

Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.Opioid Receptor Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.

Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.GABA Receptor (R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

Adrenergic Receptor Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.Reverse Transcriptase Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.Adrenergic Receptor Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36.

AChR Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.

AChR Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.Histamine Receptor Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.

Histone Methyltransferase Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.Estrogen/progestogen ReceptoEstradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

Potassium Channel Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.Estrogen/progestogen ReceptoEthynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

Histamine Receptor Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.Reverse Transcriptase Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Estrogen/progestogen ReceptoAltrenogest is a progestogen structurally related to veterinary steroid trenbolone.PDE Anagrelide is a drug used for the treatment of essential thrombocytosis.

5-HT ReceptorHistamine Receptor Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM.

Carbonic Anhydrase Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.Topoisomerase Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.

5-HT Receptor Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.Adrenergic Receptor Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Histamine Receptor Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.Ropinirole a selective dopamine D2 receptors inhibitor with IC50 of 29 nM.

Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM.COX Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.

Autophagy Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 ¦ÌM

Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.Histamine Receptor Fexofenadine inhibits histamine H1 receptor with IC50 of 246 nM.

MAO Moclobemide is MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.Topoisomerase Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.

Dopamine Receptor Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.Axl Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

DPP-4 Sitagliptin phosphate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

MMP Doxycycline HCL is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP inhibitor.Clinafloxacin (PD127391) is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

Pentamidine is an inhibitor of <i>PRL Phosphatases</i> and also inhibits synthesis of DNA, RNA and protein.Histamine Receptor Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Adrenergic Receptor Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.Adrenergic Receptor Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

COX Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

Histamine Receptor Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.AChR Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.

Sodium Channel Ouabain is a selective Na+, K+-ATPase inhibitor, binds to α2 subunit and α3 subunit with Ki of 41 nM and 15 nM, respectively.Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

PDE Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.Transferase Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.

Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.Sodium Channel Procaine (Novocaine) HCl is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

AChR Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.AChR Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Histamine Receptor Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.AChR Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.

IL Receptor Dexamethasone is an interleukin receptor inhibitor and also suppresses COX-2. AChR Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.AChR Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

Sodium Channel Dibucaine (Cinchocaine) HCl is a local anesthetics.Carbonic Anhydrase Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Adrenergic Receptor Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.COX Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.

COX Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.5-HT Receptor Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.

Androgen Receptor Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by <i>Streptomyces erythreus</i>, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.Vitamin D3 (Cholecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM.

5-HT Receptor Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.Adrenergic Receptor

PKC Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.AChR Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

AChR Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.NF-κB Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-?oB inhibition and free radical scavenging.

Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.Proton Pump Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.

Adrenergic Receptor Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.COX Mefenamic acid is a competitive inhibitor of COX-1 and COX-2.

P2 ReceptorSodium Channel Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

Autophagy Sulfacetamide Sodium is an anti-biotic.5-HT Receptor Lorcaserin HCl is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.5-HT Receptor

5-HT Receptor Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. Histamine Receptor Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

TopoisomeraseAdrenergic Receptor Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.

HDAC Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity.

Vitamin D2 is a selective inhibitors of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

Guanabenz (WY-8678) Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.

Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.

Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.

Adrenergic Receptor Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.JAK Tofacitinib citrate (CP-690550) is a potent JAK3 inhibitor with IC50 of 1 nM.

Bcr-Abl FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM.GluR LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors and rat neurons expressing native mGlu2/3 receptors with Ki of 149 nM, 92 nM and 88 nM, respectively.

CFTR PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM.p38 MAPK VX-702 is a highly selective inhibitor of p38 MAPKα with IC50 of 4-20 nM.

Src PP2 is Src kinase inhibitor, potently inhibits GST-Src activity with IC50 of 100 nM.STAT Stattic inhibits STAT3 with IC50 of 5.1 μM.

IAPPI3K IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM.

PARP AZD2461 is a poor P-glycoprotein substrate with lower affinity for Pgp than does olaparib.EGFR

ATPase Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells.Proteasome Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.

CFTR VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.Histone demethylases GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3/UTX with IC50 of 60 nM.

GABA Receptor (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM.GluR

Integrin Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively.Wnt/beta-catenin KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.

ATPase (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases with IC50 from 0.5-5 μM.DNA Methyltransferase Zebularine is an inhibitor of cytidine deaminase and also inhibit DNA methylation.

TRPV AMG 517 is a potent and selective transient receptor potential vanilloid-1 (TRPV1) antagonist with IC50 of <10 nM. E3 Ligase Tenovin-1 protects against MDM2-mediated p53 degradation, which invloves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

HDAC Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM.PI3K GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor.

IGF-1R PQ 401 is an IGF-1R inhibitor with IC50 of <1 μM.JAK ZM39923 is an JAK inhibitor for JAK1, JAK3, EFGR and TGM2 with IC50 of 4.4 μM, 7.1 μM, 5.6 μM and 10 nM, respectively.

Pim SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM.Histone Methyltransferase BIX01294 is an inhitor of G9a histone methyltransferase with IC50 of 2.7 μM.

ATM/ATR VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.EGFR AG 18 inhibits EGFR with IC50 of 35 μM.

5-HT Receptor PRX-08066 is a selective 5-HT2B antagonist with IC50 of 3.4 nM.Cannabinoid Receptor CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM.

GPR GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32.CSF-1R CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively.

Potassium Channel TAK-438 is a novel potassium-competitive acid blocker (P-CAB) type antisecretory agent that reversibly inhibits gastric H+, K+-ATPase with IC50 of 19 nM at pH 6.5.Akt AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively.

PPAR GW0742 is a potent and highly selective PPARβ/δ agonist, binding to hPPARδ with IC50 of 1 nM.5-HT Receptor Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

SGLT Empagliflozin (BI-10773) is a potent and selective SGLT2 inhibitor with IC50 of 3.1 nM.FLT3 TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.

c-Kit Tyrphostin AG 1296 (AG 1296) is an inhibitor of PDGFR, FGFR and c-Kit with IC50 of < 1 μM, 12.3 μM and 1.8 μM, respectively.PPAR GSK3787 is as a potent and selective antagonist of PPARδ with pIC50 of 6.6.

P-gp Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM.PPAR WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with ED50 of 1.5 μM.

CXCR Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.Rac NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of about 50 μM.

Syk

Embelin, from the Japanese Ardisia herb, is a fairly potent, nonpeptidic, cell-permeable inhibitor of XIAP and efficiently overcomes the protective effect of XIAP XLALP to apoptosis.

NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of L-glutamate.

PDE Apremilast (CC-10004) is a potent PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.

GluREGFR Butein, a plant polyphenol isolated from <i>Rhus verniciflua</i>, inhibits EGFR tyrosine phosphorylation with IC50 of 8 μM.

TNF-alpha Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.PARP UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM.

mTOR GDC-0349, is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM.CSF-1R GW2580 is a selective inhibitor of human c-FMS with IC50 of 30 nM.

HDAC Scriptaid is an inhibitor of histone deacetylase.Bcl-2 ABT-199 is a Bcl-2-selective inhibitor with Ki of < 0.010 nM.

Endothelin Receptor Macitentana (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.Saracatinib (AZD0530) is a Src inhibitor for c-Src and v-Abl with IC50 of 2.7 nM and 30 nM, respectively.

AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.

Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM.

Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of Flt3, PDGFRβ and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively.Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM.

Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.

Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM.VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..

MS-275 is an HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively.Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.

BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively. Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM.

Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively.

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.

SL327 is a selective inhibitor for MEK1 and MEK2 with IC50 of 0.18 μM and 0.22 μM, respectively.

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.

PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM.

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. SB 202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α and p38β with IC50 of 50 nM and 100 nM, respectively.

MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively.PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM, respectively.

GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts.

PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.

KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively.GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.

JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively.BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.U0126-EtOH is a highly selective inhibitor of MEK1 and MEK2 with IC50 of 0.07 μM and 0.06 μM, respectively.

ZM-447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively.GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.

LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation.

Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.

LY315920 (Varespladib) is a potent and selective secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.

XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.

GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively.PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.

Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively.

XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively.

YM155 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor for survivin with IC50 of 0.54 nM.INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM and a mediator of oxidant-induced myocyte dysfunction during reperfusion.

AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.

Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.

Andarine (GTX-007) is a selective nonsteroidal androgen receptor (AR) agonist with Ki of 4 nM.

17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.

AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively.Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively. Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM.Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

PLX-4720 is a potent and selective inhibitor of B-RafV600E and c-Raf-1Y340D/Y341D with IC50 of 13 nM and 6.7 nM, respectively.Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively.

Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.MK-8245 is an inhibitor of stearoyl-CoA desaturase (SCD) which targets the liver with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1.

TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM.

E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively.

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules.Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.

CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively.

CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.JNJ 26854165 (Serdemetan) is an orally bioavailable HDM2 (an E3 ligase) antagonist.

WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFRL858R and EGFRL858R/T790M with IC50 of 2 nM and 8 nM, respectively. Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM.

BIIB021 is a novel inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectivley.

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively.

Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM.

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic

PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively.

Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM.

Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively.

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM.

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS).

Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.

Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers.Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.Raloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

AG-1024 (Tyrphostin) is a specific IGF-1R and IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively.

Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.

Agomelatine is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively.

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex.

AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.

AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism.

BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM.PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively.

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

Asenapine ihibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Camptothecin (Camptohecine, 20-(S)-Camptothecin, CPT, NSC100880) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM.

Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1.

Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM.Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.

Costunolide inhibits FPTase with IC50 of 20 μM and also inhibits telomerase with IC50 of 90 μM and 65 μM in MCF-7 and MDA-MB-231 cells.

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI)class.Flupirtine maleate is the salt form of Flupirtine, which is a non-opioid, centrally acting analgesia, muscle relaxation and neuroprotection.

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

TG100-115 is a potent and dual selective inhibitor for PI3Kγ and PI3Kδ with IC50 of 83 nM and 235 nM, respectively.

Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively.

Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

GSK1059615 is a novel and dual inhibitor of PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR with IC50 of 0.4 nM, 0.6 nM, 2 nM, 5 nM and 12 nM, respectively.MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM and 7 nM, respectively.

Rigosertib (Estybon, Novonex, ON-01910) is a non-ATP-competitive inhibitor of PLK1 (Polo-like kinase 1) with IC50 of 9 nM.Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.

INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth.Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.

Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.

Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant.Stavudine is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.

Tenofovir disoproxil fumarate belongs to nucleotide analogue reverse transcriptase inhibitors (nRTIs).

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.Alfuzosin(Uroxatral) is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Droxinostat (CMH, 5809354) is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively.

Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

Sumatriptan succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.Tianeptine is a selective serotonin reuptake enhancer (SSRE) compound used for treating major depressive episodes.

Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Venlafaxine is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI).

Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.

Zileuton (ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM.Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.

Tipifarnib (Zarnestra, R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM.PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, repectively.

Cilomilast (SB-207499) is a potent LPDE4 and HPDE4 inhibitor with IC50 of 100 nM and 120 nM, respectively.Zibotentan (ZD4054) is a specific Endothelin A (ETA) antagonist with IC50 of 21 nM.

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively.

Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent.

TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.Safinamide Mesylate is mesylate salt of Safinamide, which selectively and reversibly inhibits MAO-B with IC50 of 0.45 μM.

GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.AS703026 is a highly selective and potent non-competitive inhibitor of MEK1/2 with IC50 of 5-11 nM.

SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM.

VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM.LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with Ki of 60 nM.

HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk)1 with IC50 of 118 nM.AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively.

PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.Naratriptan (Amerge) is a triptan agent that is used for the treatment of migraine headaches.

PIK-93 is a novel and potent inhibitor of PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively.AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor.

Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.

Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.Dyphylline(Dilor, Lufyllin, diprophylline) is a xanthine derivative with bronchodilator and vasodilator effects.

Irbesartan (Avapro, SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.

CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively.XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.

AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.

AC220 (Quizartinib) is a potent and selective inhibitor of Flt3ITD and Fltwt with IC50 of 1.1 nM and 4.2 nM, respectively.LY2811376 is a non-peptidic BACE1 inhibitor with IC50 of 239 nM/249 nM and also decreases the Aβ secretion with EC50 of ~300 nM.

Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively.

Oligomycin A is a specific inhibitor of complex V (ATP synthase) of the electron transport chain.

AZD7762 is a novel CHK1 and CHK2 inhibitor with IC50 of 5 nM and <10 nM, respectively.

DMXAA (ASA404) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively.Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.

Saxagliptin (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

SB-408124 (Tocris-1963) is a non-peptide antagonist for OX1 with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively.

PHT-427 is a dual Akt and PDPK1 inhibitor with Ki of 2.7 μM and 5.2 μM, respectively.KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and S6K with IC50 of 32 nM/17 n/47 nM and 85 nM, respectively.BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively.

Fasudil is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.

BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM.

PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC50 of 11 nM and 16 nM, respectively.

H 89 2HCl is a mutiple-targeted inhibitor for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b with IC50 of 80 nM, 120 nM, 135 nM, 270 nM, 2600 nM and 2800 nM, respectively.

Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells.Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.Olmesartan medoxomil (Benicar) is a compound which is hydrolyzed to olmesartan that is a selective AT1 subtype angiotensin II receptor antagonist.

Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.Pyridostigmine Bromide(Mestinon) is a parasympathomimetic and a reversible cholinesterase inhibitor.

Cefoperazone is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.

Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Alendronate (Fosamax) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.

Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

Allopurinol Sodium(Aloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 µM for CYP2C9)

Ibuprofen (Advil, Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.Amprenavir is a HIV protease inhibitor with IC50 of 14.6 ng/mL in wild-type HIV isolates.

Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.

Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

Flucytosine (5-Fluorocytosine, 5-FC, Ancobon) is an antifungal drug with IC50 of 0.93 μM in C. albicans.Aminoglutethimide (AMG, Cytadren) is an aromatase inhibitor with IC50 of 10 μM.

Aminophylline(Phyllocontin, Truphylline) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.

Torsemide(Demadex) is a pyridine-sulfonyl urea type loop diuretic with an IC50 of 2.7 ± 0.17 μM.Didanosine(Videx, Videx EC) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form.Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.

Lamivudine(Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.

Adefovir Dipivoxil(Preveon, Hepsera) works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

Telmisartan (Micardis) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Nevirapine(Viramune) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.Esomeprazole magnesium(Nexium) is a proton pump inhibitor to reduce gastric acid secretion.

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.Nisoldipine (Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.

Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.Quetiapine fumarate(Seroquel) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

Toremifene Citrate(Fareston, Acapodene) is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.

Bacitracin zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.Simvastatin (Zocor) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .

Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 μM.

Acadesine results in accumulation of ZMP, which mimics both activating effects of AMP on AMPK and AMPKK.The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.

Amlodipine (Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.

Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.Betaxolol hydrochloride (Betoptic) is a β1 adrenergic receptor blocker with IC50 of 6 μM.

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.

Butoconazole nitrate is an anti-fungal agent for IL-2, TNFα, IFN and GM-CSF with IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively.

Azithromycin (Zithromax) is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.Flubendazole (Flutelmium) is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM.

Cimetidine(Tagamet), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.

Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor.

Felodipine (Plendil) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.

Nizatidine is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE.Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.

Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 μMTropisetron hydrochloride is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Amlodipine(Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.

Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer.

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 ¦ÌM and 6.0 ¦ÌM, respectively.

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.Metformin hydrochloride(Glucophage) is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.

Nefiracetam (Translon) is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.Meglumine is an amino sugar derived from sorbitol for THP-1 cells with IC50 of 22 μg/mL.

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.Ondansetron (Zofran) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.Elvitegravir (EVG, JTK-303/GS-9137) is a HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively.Raltegravir (MK-0518, Isentress) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectivly.

Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.

BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively.Suplatast tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.

ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively.

Bifonazole is an antifungal agent and a prostatic aromatase activity inhibitor with IC50 of 1.6 μM.

Metoprolol tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 μM.

Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively.

Ketotifen fumarate (Zaditor) is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively.

Candesartan cilexetil (Atacand) is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg

Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM.

Gabexate is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.Rebamipide is a cholecystokinin type 1 (CCK1) receptor inhibitor for inhibiting [125I]BH-CCK-8S with IC50 of 37.7 μM.

Phentolamine mesilate is a nonselective alpha-adrenergic antagonist with IC50 of 0.1 μM.

Memantine hydrochloride (Namenda) is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Cyproheptadine hydrochloride (Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM.Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.Lornoxicam (Xefo) is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

Strontium ranelate (Protelos) is a strontium(II) salt of ranelic acid for (-)-desmethoxyverapamil binding to calcium channel with IC50 of 0.5 mM.Captopril (Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.

Orphenadrine citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Hytrin (terazosin) is an alpha-adrenergic blocker used to treat high blood pressure and enlarged prostate.Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.

Ozagrel hydrochloride is a selective thromboxane A2 synthetase enzyme inhibitors with IC50 of 11 nM, used as antiasthmatic agent.Mitiglinide is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Atorvastatin (Lipitor) is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 ¦ÌM, which is used for the treatment of hypertension and congestive heart failure.Cleviprex (Clevidipine) is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure.

Cilazapril is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.Adiphenine is a nicotinic receptor inhibitor with IC50 of 15 ¦ÌM, used as an antispasmodic drug.

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.Rivastigmine, a cholinesterase inhibitor with IC50 of 5.5 μM, ues as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.

Dexmedetomidine is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.Fosinopril sodium (Monopril) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).

Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.Temocapril HCl is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

Rasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

Naltrexone is an opioid receptor antagonist with IC50 of 8 nM used primarily in the management of alcohol dependence and opioid dependence.

Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM.

Bazedoxifene HCl is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM.Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.

Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analogue.

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

CGS 21680 hydrochloride is an A2A adenosine receptor agonist with an Ki of 27 nM.BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.

KW-2449 potently inhibits Flt3, Abl and Aurora A with IC50 of 6.6 nM, 14 nM and 48 nM, respectively.

Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoformsPF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM.

Rosuvastatin calcium is an competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.

MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.

MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively.

BGJ398 (NVP-BGJ398) is a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM, respectively.AST-1306 is a novel irreversible inhibitor of EGFR and ErbB4 with IC50 of 0.5 nM and 0.8 nM, respectively.

SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively.Avasimibe inhibits ACAT and CYP2C9 with IC50 of 3.3 μM and 2.9 μM, respectively.

AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, respectively.

SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively.

BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively.

NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively.OSI-420 is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for inhibition of human EGFR and EGFR autophosphorylation with IC50 of 2 nM and 20 nM, respectively.

PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively.

Formestane(Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM.

Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.

Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.

Flunixin meglumine is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity. Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 (Ki, 14.8 nM) and serotonin 5-HT2(Ki, 3.98 nM) receptors antagonist properties.

Cisatracurium besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.

AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, respectively.DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.

Apatinib (YN968D1) is an orally bioavailable, selective VEGFR2 inhibitor with IC50 of 1 nM.

Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor and also inhibits an E3 ubiquitin ligase called "anaphase-promoting complex/cyclosome (APC/C)".

Eltrombopag (SB-497115-GR, Promacta, Revolade) is a small molecule agonist of the c-mpl (TpoR) receptor with an IC50 of 0.69 μM for the inhibition of hERG K+ channel tail current.

Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRβ with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.

Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.Esomeprazole sodium (Nexium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively.

Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.WP1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

Abiraterone acetate (CB7630, CB 7630, CB-7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively.

CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM.(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM.

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.Aloe-emodin is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.Asiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.

Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.

Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway.

Icariin is a flavonol and PDE5 inhibitor with IC50 of 1.0, 0.75, and 1.1 μM for PDE5A1, A2, and A3, respectively.Luteolin is a PDE4 inhibitor and a general phosphodiesterase inhibitor, and an Interleukin 6 inhibitor.

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.Neohesperidin is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.

Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

5-Hydroxytryptophan(5-HTP) is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme aromatic-L-amino-acid decarboxylase with the help of Vitamin B6.Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 μM for HeLaS3 cells

Dioscin(Collettiside III) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.

Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 75 nM and 0.19 μM.

Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml. Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

Salidroside (Rhodioloside; Rhodosin) is a glucoside compound with an IC50 of 4.99 ± 0.23 μg/mL for the proliferation of SACC-2 cells.Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge.

Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM.

Astragaloside A is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. 20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods.

10-Hydroxycamptothecin (10-HCPT, 10-hydroxy-CPT, OHCPT, NSC107124) is a DNA topoisomerase I inhibitor with potent anti-tumor activity.Apocynin (Acetovanillone) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.Synephrine HCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

Equol is an isoflavandiol metabolized from daidzein by bacterial flora in the intestines.Amantadine hydrochloride(Symmetrel) is used to treat or prevent infections of the respiratory tract caused by a certain virus.

Amfebutamone (Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4μM for the reuptake of dopamine and norepinephrine, respectivelyBenserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

Bupivacaine hydrochloride(Marcain) is a more potent cAMP production inhibitor with an IC50 of 2.3 μMBethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currentsClonidine hydrochloride(Catapres) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.

Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.Pramipexole (Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.

Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.Fluocinolone(Flucort-N) acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.

Gallamine triethiodide(Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.Hexestrol binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM.Manidipine HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.

Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE

Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.

Olanzapine(Zyprexa) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.

Olopatadine hydrochloride(Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine

Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.Pancuronium (Pavulon) is a competitive acetylcholine antagonist with an IC50 of 5.5 ¡À 0.5 nM

Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.Propafenone(Rytmonorm) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

Racecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 μMRosiglitazone maleate (Avandia) is an anti-diabetic agent in the thiazolidinedione class of agents.

Salbutamol (Albuterol) is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ¡À 4.3 nM

Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μMSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide with an IC50 of 249 μg/ml for P. vivax

Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

Maprotiline hydrochloride (Deprilept, Ludiomil, Psymion) is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

Naphazoline hydrochloride (Naphcon) is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Epinephrine bitartrate (D02149, Adrenalinium) is alpha- and beta-adrenergic receptor stimulator.

L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines.DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.

Phenytoin sodium (Dilantin) is an inactive voltage-gated sodium channel stabilizer.Phenytoin (Lepitoin; NSC 8722; Phenytek; Phenytoine; Sodanton; Zentropi) is an inactive voltage-gated sodium channel stabilizer.

Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively.Dopamine hydrochloride (Inotropin) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

Ritodrine hydrochloride (DU 21220; Miolene; NSC 291565; Pre-Par) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.

Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class.

Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.

Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist.

Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist.

Daphnetin is an inhibitor of EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively.Clarithromycin (Biaxin, Klacid) is a macrolide antibiotic and a CYP3A4 substrate and inhibitor.

Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively.

Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.

Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Tetracaine hydrochloride (Pontocaine) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

Quinapril hydrochloride (Accupril) is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM.

Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.

Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28¦ÌM for the inhibition of AVP-induced platelet aggregation.Gliclazide (Diamicron) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ¡À 30 nM

Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone.Mifepristone (Mifeprex, RU-486, RU-38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

Lonidamine is an orally administered small molecule hexokinase inactivator with an IC50 of 0.85 mM.

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

Scopine HCl is the hydrochloride of Scopine, which is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.

Isoprenaline is a non-selective β-adrenoceptor, inhibits the 3H-inositol phosphate accumulation with IC50 of 0.08 μM.

Trazodone is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.

Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM. LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.

AZD5438 is a potent inhibitor of CDK1, CDK2 and CDK9 with IC50 of 16 nM, 6 nM, and 20 nM, respectively.

PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM.OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.

PKI-587 is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM, respectively.

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM in α7*-expressing SH-EP1 cells.GW3965 is a potent, selective LXR agonist, which exhibits its potency in the LXRα/SRC1 LiSA and LXRα-GAL4 with EC50 of 125 nM and 190 nM, respectively.

BMS-806 (BMS 378806) selectively inhibitis the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.

DCC-2036 is a conformational control inhibitor of Abl1 and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, respectively.CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.

NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, respectively.

PF-04929113 (SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and also inhibits Her-2 degradation with IC50 of 37 nM.GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells.

WYE-125132 is a highly potent, ATP-competitive and specific mTOR inhibitor with IC50 of 0.19 nM.

Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM.

S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM.

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.

A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively.

PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

A 922500 is a DGAT-1 inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively.

NSC-207895 suppresses MDMX with IC50 of 2.5 ¦ÌM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulate MDM2, an E3 ligaseFlavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.

PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells.

NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM.R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively.

WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.

BMY 7378 is a multiple inhibitors of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively.TG101209 is a potent inhibitor of JAK2, Flt3 and RET with IC50 of 6 nM, 25 nM and 17 nM, respectively.

GDC-0980 (RG7422) is a potent, selective inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 5 nM, 27 nM, 7 nM, and 14 nM, and also a mTOR inhibitor with Ki of 17 nM.

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM and inhibits fatty acid synthesis with IC50 of 3.2 μM.

CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM.KX2-391 (KX01) is a highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines .

GSK1838705A is a potent inhibitor of IGF-1R, IR and ALK with IC50 of 2.0 nM, 1.6 nM and 0.5 nM, respectivelyLY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively.

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively.

LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM and 0.082 nM for membrane- and cell-based γ-secretase.CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM.

TAK-901 is a novel inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM, respectively.AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively.

Nilvadipine (ARC029) is a potent calcium channel blocker with an IC50 of 0.03 nM.

JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM.PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively.

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

SB 415286 is a potent GSK3α and GSK3β inhibitor with IC50 of 78 nM and ~78 nM, respectively.

Crenolanib (CP-868596) is a potent and selective inihibitor of PDGFRα with IC50 of 10 nM in PDGFRα over-expressed CHO cells.

PKI-402 is a potent dual PI3K/mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR with IC50 of 2 nM, 7 nM, 16 nM, 14 nM, and 3 nM, respectively.GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B and Aurora C with IC50 of 3.5 nM and 6.5 nM, respectively.

PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM.

CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively.CHIR-98014 is a potent and selective GSK-3 inhibitor for GSK-3ɑ and GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively.

AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively. AMG 458 is a potent c-Met inhibitor of human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM.

Anacetrapib (MK0859) is a potent and selective rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, respectively

PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with IC50 of 45 nM.

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM. AT-406 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM

PI3K/HDAC Inhibitor I is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.

MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation.

Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.

SB705498 is a TRPV1 antagonist for hTRPV1 with pIC50 and pKi of 7.1 and 7.6 in HEK293 cells. MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively.

Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.

PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively.

RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells, and also inhibits MDM2-p53 interaction by targeting to p53.

AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.

TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively.

Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM.Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM.

WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells .Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively.

BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα and PI3Kβ with IC50 of 0.469 nM and 3.72 nM, respectively.Galeterone (TOK-001, VN/124-1) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively.

Sirtinol is a specific SIRT1 and SIRT2 inhibtor with IC50 of 131 μM and 38 μM, respectively.

Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively.

GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively.

AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

Ciproxifan is a highly potent and selective H3-receptor antagonist with IC50 of 9.2 nM.

Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.

NVP-TAE226, a potent dual FAK/IGF-1R, inhibiting FAK and IGF-1R with IC50 of 5.5 nM and 0.14 μM, respectively.

Tideglusib (NP031112, NP-12) is a potent non ATP-competitive inhibitor of GSK3 with IC50 of 60 nM.

ML133 is a potent potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5).Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM.

JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human).

Epiandrosterone (3β-androsterone) is a steroid hormone with weak androgenic activity which acts as a L-type Ca2+ channel antagonist.

BI-D1870 is an ATP-competitive inhibitor of ribosomal S6 for RSK1, RSK2, RSK3 and RSK4 with IC50 of 31 nM, 24 nM, 18 nM and 15 nM, respectively.

Semaxanib (SU5416) is a potent and selective VEGFR (Flk-1/KDR) inhibitor with IC50 of 1.04 μM.Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

SB-269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3.Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.

BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively.

SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.Dizocilpine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

E7050 is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, respectively.

IEM 1754 dihydrobroMide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

VUF10166 is a novel, potent and competitive antagonist to 5-HT3A with Ki of 0.04 nM.

U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with IC50 of 45.1 nM and 4.5 nM, respectively.WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.

Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of < 10 nM.TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.

Camostat is a trypsin-like protease inhibitor, inhibiting matriptase and human neutrophil elastase with IC50 of 0.5 μM and 0.2 μM, respectively.Prucalopride is a selective, high affinity 5-HT receptor agonistfor 5-HT4a and 5-HT4b with Ki of 2.5 nM and 8 nM, respectively.

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively.GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM.

Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively.

PF 477736 is a ChK inhibitor against ChK1, ChK2, VEGFR2, Yes and Fms with IC50 of 0.49 nM, 47 nM, 8 nM, 14 nM and 10 nM, respectively.JNJ-7777120 is a potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM.

Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively.

VU 0361737 is a selective positive allosteric modulator for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively.

Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.

Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).Dapivirine is an nonnucleoside reverse transcriptase inhibitor for HIV reverse transcriptase with IC50 of 24 nM.

GW9662 is a selective PPAR antagonist, inhibiting PPARγ, PPARα and PPARδ with IC50 of 3.3 nM, 32 nM and 2 μM, respectively. HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.Mozavaptan (OPC-31260) is a novel competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively.

PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM. Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with IC50 of 5 nM.

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.Rivaroxaban (Xarelto, BAY 59-7939) is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM, respectively.

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. Plerixafor 8HCl (DB06809, Mozobil, AMD3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.

Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, respectively.

PMSF (Phenylmethyl sulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor.

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively.Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.

Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.

Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with Ki of 550 and 102 nM, respectively.

Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa.

Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

Ambroxol HCl is a potent inhibitor of the neuronal Na+ channels with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, respectively.

Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.

Piracetam is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.(R)-baclofen is a derivative of gamma-aminobutyric acid primarily used to treat spasticity.

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.

Tripelennamine is a widely used H1 antagonist, inhibiting PhIP glucuronidation with IC50 of 30 μM.

Estradiol is a synthetic ester used to treat menopausal symptoms and hormone deficiencies.

Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 ¦ÌM

Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM.

Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties.

Pergolide mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Sitagliptin phosphate (MK-0431) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

Doxycycline HCL is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP inhibitor.Clinafloxacin (PD127391) is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

Pentamidine is an inhibitor of <i>PRL Phosphatases</i> and also inhibits synthesis of DNA, RNA and protein.Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM.

Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

Ouabain is a selective Na+, K+-ATPase inhibitor, binds to α2 subunit and α3 subunit with Ki of 41 nM and 15 nM, respectively.

Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.

Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16.Procaine (Novocaine) HCl is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Doxapram HCl inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.

Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by <i>Streptomyces erythreus</i>, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.Vitamin D3 (Cholecalciferol) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM.

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-?oB inhibition and free radical scavenging.

Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.

Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.

Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

Lorcaserin HCl is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.

Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.

Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.

Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity.

Vitamin D2 is a selective inhibitors of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

Guanabenz (WY-8678) Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.

Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.

Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.

Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

DeoxyArbutin is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.

LY404039 is a potent agonist of recombinant human mGlu2, mGlu3 receptors and rat neurons expressing native mGlu2/3 receptors with Ki of 149 nM, 92 nM and 88 nM, respectively.

PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM.

PP2 is Src kinase inhibitor, potently inhibits GST-Src activity with IC50 of 100 nM.

IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM.

AZD2461 is a poor P-glycoprotein substrate with lower affinity for Pgp than does olaparib.

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells.Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3/UTX with IC50 of 60 nM.

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM.

Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively.KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.

(-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases with IC50 from 0.5-5 μM.Zebularine is an inhibitor of cytidine deaminase and also inhibit DNA methylation.

AMG 517 is a potent and selective transient receptor potential vanilloid-1 (TRPV1) antagonist with IC50 of <10 nM. Tenovin-1 protects against MDM2-mediated p53 degradation, which invloves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

ZM39923 is an JAK inhibitor for JAK1, JAK3, EFGR and TGM2 with IC50 of 4.4 μM, 7.1 μM, 5.6 μM and 10 nM, respectively.

VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.

CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM.

GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32.CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively.

TAK-438 is a novel potassium-competitive acid blocker (P-CAB) type antisecretory agent that reversibly inhibits gastric H+, K+-ATPase with IC50 of 19 nM at pH 6.5.AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively.

GW0742 is a potent and highly selective PPARβ/δ agonist, binding to hPPARδ with IC50 of 1 nM.Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Empagliflozin (BI-10773) is a potent and selective SGLT2 inhibitor with IC50 of 3.1 nM.

Tyrphostin AG 1296 (AG 1296) is an inhibitor of PDGFR, FGFR and c-Kit with IC50 of < 1 μM, 12.3 μM and 1.8 μM, respectively.

Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM.WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with ED50 of 1.5 μM.

Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of about 50 μM.

Embelin, from the Japanese Ardisia herb, is a fairly potent, nonpeptidic, cell-permeable inhibitor of XIAP and efficiently overcomes the protective effect of XIAP XLALP to apoptosis.

is a specific agonist for NMDA receptor mimicking the action of L-glutamate.

Apremilast (CC-10004) is a potent PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.

Butein, a plant polyphenol isolated from <i>Rhus verniciflua</i>, inhibits EGFR tyrosine phosphorylation with IC50 of 8 μM.

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

GDC-0349, is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM.

Macitentana (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.

XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex.

AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.

Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.

ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively.

Pioglitazone hydrochloride (Actos) is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.

Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 ¦ÌM, which is used for the treatment of hypertension and congestive heart failure.

NVP-BHG712 is a specific inhibitor of c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM and also inhibits EphB4 and VEGFR2 with ED50 of 25 nM and 4.2 μM, respectively.

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays antiangiogenic, antiinflammatory, and antitumor properties due to the inhibitory effect on the PI3K/Akt pathway.

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.

Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Dioscin(Collettiside III) is a saponin extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.

PP-121 is a multi-target inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, respectively, and also inhibits DNA-PK with IC50 of 60 nM.

GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.

PF-04691502 is an ATP-competitive, selective inhibitor of PI3K(α/β/δ/γ)/mTOR with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, also inhibits Akt phosphorylation on T308/S473 with IC50 of 7.5 nM/3.8 nM.

Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM

Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).

Plerixafor 8HCl (DB06809, Mozobil, AMD3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.

Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.

Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM.

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.