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WORLD SYMPOSIUM ONPULMONARY HYPERTENSION

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INTRODUCTIONTraditionally the PH World Symposia series, started in Geneva in 1973 and held every 5 years after the Evian edition in 1998 (Venice 2003, Dana Point 2008, Nice 2013), has marked the progresses in pulmonary hypertension science and has anticipated future developments. The published supplement including the symposia proceedings constitutes a collection of articles among the most cited in this scientific area.

Each new edition of the WSPH series has increased the attendance compared with the previous one, testifying the growing interest of the stakeholders of this area. More than 1200 international physicians attended the 5th WSPH – Nice 2013.

The structure of the 6th WSPH consists in 13 sessions where world specialists in the field, divided in 13 Task Forces, present the results of their studies developed in the last two years and regarding some topic items:1. Pathology & Pathobiology2. Genetics & Genomics3. Pathophysiology of the RV and of the Pulmonary Circulation4. PH Haemodynamic Definitions and Clinical Classifications and

Characteristics of Specific PAH Subgroups5. Diagnosis of Pulmonary Hypertension 6. Risk Stratification and Medical Therapy of Pulmonary Arterial

Hypertension7. Right Ventricular Assistance and Lung Transplantation8. Trials Design & New Therapies for Pulmonary Arterial

Hypertension9. PH due to Left Heart Diseases10. PH due to Chronic Lung Diseases11. CTEPH12. Pediatric PH13. Patients’ Perspectives

The objectives of the 6th WSPH are:• Review of the major advances in pulmonary vascular science in

the past 5 years• Analyze the available evidence in different basic and clinical

areas by expert task forces• Evaluation of the gaps of evidence in different areas and

proposals for future collaborative research programs• Elaboration of documents by the task forces, summarizing the

results of pre-symposium meetings (previous 18-24 months)• Discussion of the task forces documents at the symposium

sessions with worldwide experts and with other stakeholders• Final drafting of peer reviewed papers to be included in a

supplement (prestigious medical journal) to facilitate the implementation of the 6th WSPH conclusions.

Our purpose is to foster with the Symposium constructive scientific interactions and collaborations in the very unique scenario of the bay of Nice.

For the Steering CommitteeNazzareno Galiè

Vallerie V. McLaughlinLewis J. Rubin

Gérald Simonneau



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SCIENTIFIC PROGRAM ENDORSED BY The Symposium Steering Committee• Adaani Frost, MD

Houston, TX – USA• Nazzareno Galiè, MD

Bologna, Italy• Ardeschir H. Ghofrani, MD

Giessen, Germany• Marc Humbert, MD

Paris, France• Anne Margaret Keogh, MD

Sydney, Australia• Michael D. McGoon, MD

Rochester, MN – USA• Vallerie V. McLaughlin, MD

Ann Arbor, MI – USA• Nicholas W. Morrell, MD

Cambridge, UK• Lewis J. Rubin, MD

San Diego, CA – USA• Werner Seeger, MD

Giessen, Germany• Gérald Simonneau, MD

Paris, France• Rogerio Souza, MD

Sao Paulo, Brazil

The Symposium Secretariat

I&C s.r.l.Via Andrea Costa, 202/640134 Bologna (IT)Stefania Parolari and Giulia DeliaPh: +39 - 051.614.4004Fax: +39 - 051.614.2772@: [email protected]



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Index• MAP OF THE CONGRESS CENTER 6• SYMPOSIUM TIMETABLE 7• SCIENTIFIC PROGRAM 8

TUESDAY, FEBRUARY 27• TASK FORCE 1 – Pathology & Pathobiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8• TASK FORCE 2 – Genetics and Genomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8• TASK FORCE 3 – Pathophysiology of the RV and of the Pulmonary Circulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9• TASK FORCE 4 – PH Haemodynamic Definitions and Clinical Classifications and Characteristics of Specific PAH Subgroups . . . . . . . . 9• TASK FORCE 5 – Diagnosis of Pulmonary Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

WEDNESDAY, FEBRUARY 28• TASK FORCE 6 – Risk Stratification and Medical Therapy of Pulmonary Arterial Hypertension . . . . . . . . . . . . . . . . . . . . . 10• TASK FORCE 7 – Right Ventricular Assistance and Lung Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10• TASK FORCE 8 – Trials Design & New Therapies for Pulmonary Arterial Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . 10• TASK FORCE 9 – PH due to Left Heart Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

THURSDAY, MARCH 1• TASK FORCE 10 – PH due to Chronic Lung Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11• TASK FORCE 11 – CTEPH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12• TASK FORCE 12 - Pediatric PH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12• TASK FORCE 13 – Patients’ Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

• POSTER SESSIONS 13• BEST POSTER AWARDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13• POSTERS EXPOSED ON TUESDAY, FEBRUARY 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15• POSTERS EXPOSED ON WEDNESDAY, FEBRUARY 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31• POSTERS EXPOSED ON THURSDAY, MARCH 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

• GENERAL INFORMATION 50• INDEX OF POSTERS AUTHORS AND TASK FORCES MEMBERS 53• SPONSORS 69



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Map of the AcropolisCONGRESS CENTER

Agora 1 Agora 2

Agora 3

REGISTRATION DESKSAND

ASSOCIATION BOOTHS

MAIN ENTRANCE

< AGORA 2

SLIDECENTER

CLOAKROOM

AGORA 2 >

LUNCHAREA

LUNCHAREA

POSTERS AND COFFEE

BREAKAREA

POSTERS AND COFFEE

BREAKAREA

> MYKONOS BAR AND RELAX AREA

APOLLON <MEETING HALL



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Symposium timetable TF=Task Force

time Tuesday, February 27 time Wednesday, February 28 Thursday, March 1

08.30-09.00 Apollon Hall Opening Ceremony

09.00-10.30 Apollon Hall TF 1. Pathology & Pathobiology

09.00-10.30 Apollon Hall

TF 6. Risk Stratification and Medical Therapy of Pulmonary Arterial

HypertensionTF 10. PH due to Chronic Lung Diseases

10.30-11.00 Agora 2 coffee break

10.30-11.00 Agora 2 coffee break coffee break

11.00-12.30 Apollon Hall TF 2. Genetics & Genomics


TF 7. Right Ventricular Assistance and Lung Transplantation TF 11. CTEPH

12.30-13.00 Apollon Hall Best Poster Awards Ceremony

12.30-14.00 Agora 2 and 3 Lunch and posters Lunch and posters

13.00-14.00 Agora 2 and 3 Lunch and posters


TF 3. Pathophysiology of the RV and of the Pulmonary Circulation


TF 8. Trials Design & New Therapies for Pulmonary Arterial Hypertension TF 12. Pediatric PH

15.30-16.00 Agora 2 coffee break

15.30-16.00 Agora 2 coffee break coffee break


TF 4. PH Haemodynamic Definitions and Clinical Classifications

and Characteristics of Specific PAH Subgroups

16.00-17.30 Apollon Hall TF 9. PH due to Left Heart Diseases TF 13. Patients' Perspectives


TF 5. Diagnosis of Pulmonary Hypertension

17.30-18.00 Apollon Hall Final remarks and next steps



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Scientific ProgramTUESDAY, FEBRUARY 27APOLLON HALL

08.30 - 09.00Opening CeremonyNazzareno Galiè, Bologna ITALYVallerie V. McLaughlin, Ann Arbor MI USALewis J. Rubin, La Jolla CA USAGérald Simonneau, Paris FRANCE

09.00-10.30Task Force 1. Pathology & Pathobiology CHAIR: MARC HUMBERT, Paris FRANCECHAIR: MARLENE RABINOVITCH, Stanford CA USASEBASTIEN BONNET, Chemin Sainte-Foy CANADAPETER DORFMÜLLER, Paris FRANCECHRISTOPHE GUIGNABERT, Le Plessis Robinson FRANCEJAMES R. KLINGER, Rhode Island RI USAMARK R. NICOLLS, Stanford CA USAANDREA J. OLSCHEWSKI, Graz AUSTRIASONI SAVAI PULLAMSETTI, Bad Nauheim GERMANYRALPH T. SCHERMULY, Giessen GERMANYKURT R. STENMARK, Aurora CO USA

Objectives:- State of the art- Main bench to bedside achievements- Recommendation on how to identify most relevant pathways- Most appropriate cells, tissues and animal models- Proposed Future Directions (specific and detailed)

AGORA 210.30-11.00coffee break

APOLLON HALL

11.00-12.30Task Force 2. Genetics & GenomicsCHAIR: NICHOLAS W. MORRELL, Cambridge UKCHAIR: JAMES E. LOYD, Nashville TN USAMICHEALA A. ALDRED, Indianapolis IN USAWENDY K. CHUNG, New York NY USAGREGORY ELLIOTT, Salt Lake City UT USAWILLIAM NICHOLS, Cincinnati OH USAFLORENT SOUBRIER, Paris FRANCERICHARD C. TREMBATH, London UK

Objectives:- State of the Art- Pathobiology links between mutations and disease

(why low penetrance)- Genetic counselling and healthy mutation carriers- Practical application of genomics- Proposed Future Directions (specific and detailed)

12.30-13.00Best Poster Awards Ceremony

AGORA 2 and 313.00-14.00Lunch and posters



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Scientific ProgramTUESDAY, FEBRUARY 27APOLLON HALL

14.00-15.30Task Force 3. Pathophysiology of the RV and of the pulmonary circulationCHAIR: ROBERT NAEIJE, Brussels BELGIUMCHAIR: ANTON VONK NOORDEGRAAF, Amsterdam THE NETHERLANDSKELLY MARIE CHIN, Dallas TX USAFRANÇOIS HADDAD, Palo Alto CA USAPAUL M. HASSOUN, Baltimore MD USAANNA R. HEMNES, Nashville TN USASUSAN R. HOPKINS, San Diego CA USASTEVEN M. KAWUT, Philadelphia PA USADAVID LANGLEBEN, Montreal CANADAJOOST LUMENS, Maastricht THE NETHERLANDS

Objectives:- State of the Art- Main bench to bedside achievements- MRI, echocardiography and metabolic studies- Early detection and irreversibility thresholds of RV dysfunction- Proposed future directions (specific and detailed)


APOLLON HALL16.00-17.30Task Force 4. PH haemodynamic definitions and clinical classifications and characteristics of specific PAH subgroupsCHAIR: GÉRALD SIMONNEAU, Paris FRANCECHAIR: ROGERIO SOUZA, Sao Paulo BRAZILDAVID S. CELERMAJER, Sydney AUSTRALIACHRISTOPHER P. DENTON, London UKMICHAEL A. GATZOULIS, London UKMICHAEL KROWKA, Rochester MN USADAVID MONTANI, Paris FRANCEPAUL WILLIAMS, Johannesburg SOUTH AFRICA

Objectives:- State of the art- Haemodynamic definitions- Atypical PAH- PVOD

17.30 – 19.00Task Force 5. Diagnosis of pulmonary hypertensionCHAIR: ADAANI FROST, Houston TX USACHAIR: ADAM TORBICKI, Otwock POLANDDAVID B. BADESCH, Aurora CO USASIMON GIBBS, London UKDEEPA GOPALAN, London UKDINESH KHANNA, Ann Arbor MI USAALESSANDRA MANES, Bologna ITALYRONALD J. OUDIZ, Torrance Los Angeles CA USATORU SATOH, Tokyo JAPANFERNANDO TORRES, Dallas TX USA

Objectives:- State of the art- Practice recommendations- New diagnostic tools?- Proposed future directions (specific and detailed)



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Scientific ProgramWEDNESDAY, FEBRUARY 28APOLLON HALL

09.00-10.30Task Force 6. Risk stratification and medical therapy of pulmonary arterial hypertensionCHAIR: NAZZARENO GALIÈ, Bologna ITALYCHAIR: VALLERIE V. MCLAUGHLIN, Ann Arbor MI USARICHARD N. CHANNICK, Boston MA USAROBERT P. FRANTZ, Rochester MN USAEKKEHARD GRÜNIG, Heidelberg GERMANYZHI CHENG JING, Beijing CHINAIOANA R. PRESTON, Boston MA USATOMAS PULIDO, Mexico City MEXICOZEENAT SAFDAR, Houston TX USAYUICHI TAMURA,Tokyo JAPAN

Objectives:- State of the art- Practice recommendations- General measures and non-specific therapy (pregnancy, a/c

therapy, rehabilitation)- Proposed future directions (specific and detailed)


APOLLON HALL11.00-12.30Task Force 7. Right ventricular assistance and lung transplantationCHAIR: WALTER KLEPETKO, Vienna AUSTRIACHAIR: MARIUS HOEPER, Hanover GERMANYRAYMOND L. BENZA, Pittsburgh PA USAPAUL A. CORRIS, Newcastle Upon Tyne UKMARC DE PERROT, Toronto CANADAELIE FADEL, Paris FRANCEANNE M. KEOGH, Sydney AUSTRALIACHRISTIAN KÜHN, Hanover GERMANYLAURENT SAVALE, Paris FRANCE

Objectives:- State of the art- ICU management of severe PH- Practice recommendations- Proposed future directions (specific and detailed)


APOLLON HALL14.00-15.30Task Force 8. Trials design and new therapies for pulmonary arterial hypertensionCHAIR: LEWIS J. RUBIN, La Jolla CA USACHAIR: OLIVIER SITBON, Paris FRANCEAMANY N. EL-GAZAYERLY, The Hague THE NETHERLANDSMARDI I. GOMBERG MAITLAND, Falls Church VA USAJOHN GRANTON, Toronto CANADAMICHAEL I. LEWIS, Los Angeles CA USASTEPHEN C. MATHAI, Baltimore MD USAMAURIZIO RAINISIO, Imperia ITALYNORMAN STOCKBRIDGE, Silver Spring MD USAMARTIN R. WILKINS, London UKROHAM ZAMANIAN, Stanford CA USA

Objectives:- State of the art- Current challenges- Proposed future directions (specific and detailed)




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Scientific ProgramWEDNESDAY, FEBRUARY 28APOLLON HALL

16.00-17.30Task Force 9. PH due to left heart diseasesCHAIR: JEAN LUC VACHIERY, Brussels BELGIUMCHAIR: TERESA DE MARCO, San Francisco CA USAIRINA CHAZOVA, Moscow RUSSIAN FEDERATIONJOHN G. COGHLAN, London UKMARCO GUAZZI, Milan ITALYIRENE LANG, Vienna AUSTRIAMASSIMILIANO PALAZZINI, Bologna ITALYSTEPHAN H. ROSENKRANZ, Cologne GERMANYRYAN J. TEDFORD, Charleston SC USA

Objectives:- State of the art- Current challenges- Vasoreactivity testing in left heart disease- Proposed future directions (specific and detailed)

THURSDAY, MARCH 1APOLLON HALL

09.00-10.30Task Force 10. PH due to chronic lung diseasesCHAIR: WERNER SEEGER, Giessen GERMANYCHAIR: STEVEN D. NATHAN, Falls Church VA USAJOAN ALBERT BARBERÀ, Barcelona SPAINSEAN P. GAINE, Dublin IRELANDSERGIO HARARI, Milan ITALYFERNANDO J. MARTINEZ, Ann Arbor MI USAHORST OLSCHEWSKI, Graz AUSTRIAKAREN M. OLSSON, Hanover GERMANYANDREW J. PEACOCK, Glasgow UKJOANNA PEPKE-ZABA, Cambridge UKSTEEVE PROVENCHER, Chemin Sainte-Foy CANADANORBERT WEISSMANN, Giessen GERMANY





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Scientific ProgramTHURSDAY, MARCH 1APOLLON HALL

11.00-12.30Task Force 11. CTEPHCHAIR: ARDESCHIR H. GHOFRANI, Giessen GERMANYCHAIR: NICK H. KIM, La Jolla CA USACHAIR: DAVID P. JENKINS, Cambridge UKMARION DELCROIX, Leuven BELGIUMXAVIER JAIS, Paris FRANCEMICHAEL M. MADANI, San Diego CA USAHIROMI MATSUBARA, Okayama JAPANECKHARD MAYER, Bad Nauheim GERMANYTAKESHI OGO, Osaka JAPANVICTOR F. TAPSON, Los Angeles CA USA

Objectives:- State of the art- Current challenges- Treatment selection- Proposed future directions (specific and detailed)


APOLLON HALL14.00-15.30Task Force 12. Pediatric PHCHAIR: ERIKA BERMAN ROSENZWEIG, New York NY USACHAIR: ROLF M.F. BERGER, Groningen THE NETHERLANDSSTEVEN ABMAN, Aurora CO USAIAN T. K. ADATIA, Edmonton CANADAMAURICE BEGHETTI, Geneve SWITZERLANDDAMIEN BONNET, Paris FRANCECHRISTINE GARNETT, Silver Spring MD USASHEILA G. HAWORTH BUSK, LondonUKDUNBAR IVY, Aurora CO USA



APOLLON HALL16.00-17.30Task Force 13. Patients’ perspectivesCHAIR: MICHAEL D. MCGOON, Rochester MN USACHAIR: PISANA FERRARI, Milan ITALYIAIN ARMSTRONG, Sheffield UKMIGDALIA DENIS, Miami FL USA LUKE S. HOWARD, London UKSANJAY MEHTA, London CANADANORIKO MURAKAMI, Yamatoshi JAPANBRAD A. WONG, Silver Spring MD USA

Objectives:- Mission- Narrative medicine (disease, illness, sickness)- Current challenges- Proposed future directions (specific and detailed)

17.30-18.00Final remarks and next stepsNazzareno Galiè, Vallerie V. McLaughlin, Gérald Simonneau, Lewis J. Rubin



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POSTER SESSIONS

BEST POSTER AWARDSThese posters are exposed for the whole period of the World Symposium: February 27, 28 and March 1

BASIC SCIENCE1 IMMUNE REPERTOIRE-BASED SIGNATURES IN THE BLOOD AND

IN THE LUNG VESSEL-ASSOCIATED TERTIARY LYMPHOID TISSUE IN PRE-CAPILLARY PULMONARY HYPERTENSIONSylvia Cohen-Kaminsky*[2], Sébastien J Dumas[2], Isabelle Klingel-Schmitt[3], Matthieu Vocelle[3], Anais Courtier[4], Orchidee Filipe-Santo[4], Gilles Parmentier[4], Solène Perez[4], Caroline Suberbielle[5], Sophie Caillat-Zucman[6], Gerald Simonneau[2], Frederic Perros[3], Marc Humbert[2], Morad Nakhleh[3], David Montani[2], Barbara Girerd[2], Andrei Seferian[2], Peter Dorfmüller[1]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson 92350 ~ France, [2]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Plessis-Robinson F-92350, AP-HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre F-94270, France ~, [3]

INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Plessis Robinson, F-92350 ~ France, [4]Former (Research and Development, ImmunID Technologies), Grenoble F-38054 ~ France, [5]Regional Histocompatibility Laboratory IR7, APHP, Hopital Saint Louis, Paris, F-75010 ~ France, [6]

Unit of Immunology and Genetics of Type 1 Diabetes., INSERM U986, Hôpital St-Vincent de Paul; Université Paris Descartes, Faculté de Médecine, Paris F-75014 ~ France

2 A GENOME-WIDE ASSOCIATION STUDY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONMichael Newnham*[1], Mark Toshner[1], Marta Bleda[1], William Auger[2], Joan Albert Barberà[3], Harm Jan Bogaard[4], John Cannon[5], Gerry Coghlan[6], Paul Corris[7], Marion Delcroix[8], John Dunning[5], Heather Elding[9], Simon Gibbs[10], Charaka Hadinnapola[1], David Jenkins[5], David Kiely[11], Irene Lang[12], Eckhard Mayer[13], Choo Ng[5], Andrew Peacock[14], Nicholas Screaton[5], Karen Sheares[5], Michael Simpson[15], Nicole Soranzo[9], Dolores Taboada[5], Richard Trembath[15], Steven Tsui[5], Martin Wilkins[16], Stephen John Wort[17], Stefan Gräf[1], Joanna Pepke-Zaba[5], Nicholas Morrell[1]

[1]University of Cambridge ~ Cambridge ~ United Kingdom, [2]UC San Diego ~ San Diego ~ United States of America, [3]University of Barcelona ~ Barcelona ~ Spain, [4]

VU Medical Centre ~ Amsterdam ~ Netherlands, [5]Papworth Hospital ~ Cambridge ~ United Kingdom, [6]Royal Free Hospital ~ London ~ United Kingdom, [7]Newcastle University ~ Newcastle ~ United Kingdom, [8]KU Leuven - University of Leuven ~ Leuven ~ Belgium, [9]Wellcome Trust Sanger Institute ~ Cambridgeshire ~ United Kingdom, [10]Hammersmith Hospital ~ London ~ United Kingdom, [11]Royal Hallamshire Hospital ~ Sheffield ~ United Kingdom, [12]Medical University of Vienna ~ Vienna ~ Austria, [13]Kerckhoff Heart and Lung Center ~ Bad Nauheim ~ Germany, [14]Golden Jubilee Hospital ~ Glasgow ~ United Kingdom, [15]Kings College ~ London ~ United Kingdom, [16]Imperial College ~ London ~ United Kingdom, [17]Royal Brompton Hospital ~ London ~ United Kingdom

3 GENETIC ANALYSIS OF 2,156 WHO GROUP 1 PAH PATIENTS ENROLLED IN THE PAH BIOBANKMichael Pauciulo*, Katie Lutz, Anna Walsworth, Lisa Martin, William NicholsCincinnati Children’s Hospital Medical Center ~ Cincinnati ~ United States of America



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POSTER SESSIONS

BEST POSTER AWARDSThese posters are exposed for the whole period of the World Symposium: February 27, 28 and March 1

CLINICAL SCIENCE4 REDUCED RIGHT VENTRICULAR CONTRACTILE RESERVE IN

PATIENTS WITH SYSTEMIC SCLEROSIS AND BORDERLINE PULMONARY ARTERIAL PRESSURESAlberto Maria Marra*[1], Christian Nagel[1], Benjamin Egenlauf[1], Satenik Harutyunova[1], Norbert Blank[2], Hanns-Martin Lorenz[2], Christoph Fiehn[3], Nicola Benjamin[1], Christine Fischer[4], Antonio Cittadini[5], Eduardo Bossone[6], Ekkehard Grünig[1]

[1]Centre for Pulmonary Hypertension at Thoraxclinic, University Hospital Heidelberg, Heidelberg, Germany ~ Heidelberg ~ Germany, [2]Department of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany ~ Heidelberg ~ Germany, [3]

Praxis für Rheumatologie und klinische Immunologie ~ Baden-Baden ~ Germany, [4]

Department of Human Genetics; University of Heidelberg; ~ Heidelberg ~ Germany, [5]Department of Translational Medical Sciences ~ Naples ~ Italy, [6]Department, Cardiology Division, “Cava de’ Tirreni and Amalfi Coast” Hospital, University of Salerno, Salerno, Italy ~ Salerno ~ Israel

5 RISK ASSESSMENT IN SCLERODERMA PATIENTS WITH NEWLY DIAGNOSED PULMONARY ARTERIAL HYPERTENSION: APPLICATION OF THE ESC/ERS RISK PREDICTION MODEL Valentina Mercurio*, Nermin Diab, Grace Peloquin, Rachel Damico, Todd Kolb, Stephen Mathai, Paul HassounJohns Hopkins University ~ Baltimore ~ United States of America

6 IDENTIFICATION OF GENETIC DEFECTS IN PULMONARY ARTERIAL HYPERTENSION BY A NEW GENE PANEL DIAGNOSTIC TOOLJie Song*[1], Christina Alessandra Eichstaedt[1], Rebecca Rodriguez Viales[2], Nicola Benjamin[1], Satenik Harutyunova[1], Christine Fischer[3], Katrin Hinderhofer[3], Ekkehard Grünig[1]

[1]Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]

European Molecular Biology Laboratory ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Germany

7 EFFECTIVENESS OF PERCUTANEOUS TRANSLUMINAL PULMONARY ANGIOPLASTY FOR LONG-TERM OUTCOMES IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONKaori Takeuchi*[2], Takumi Inami[2], Masaharu Kataoka[1], Hanako Kikuchi[2], Shigeta Yohei[2], Ayumi Goda[2], Haruhisa Ishiguro[2], Hideaki Yoshino[2], Toru Satoh[2]

[1]Keio University School of Medicine ~ Tokyo ~ Japan, [2]Kyorin University School of Medicine ~ Tokyo ~ Japan

8 SEQUENTIAL HYBRID THERAPY WITH PULMONARY ENDARTERECTOMY AND ADDITIONAL BALLOON PULMONARY ANGIOPLASTY FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION.Kenichi Yanaka*[1], Kazuhiko Nakayama[1], Toshiro Shinke[1], Hiromasa Otake[1], Hiroyuki Kawamori[1], Yuto Shinkura[1], Naoki Tamada[1], Hiroyuki Onishi[1], Yasunori Tsuboi[1], Seimi Kobayashi[1], Hiroshi Tanaka[2], Yutaka Okita[2], Noriaki Emoto[1], Ken-Ichi Hirata[1]

[1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine ~ Kobe ~ Japan, [2]Division of Cardiovascular Surgery, Department of Surgery, Kobe University Graduate School of Medicine ~ Kobe ~ Japan

9 EARLY DETECTION OF PULMONARY ARTERIAL HYPERTENSION IN APPARENTLY HEALTHY CHILDREN BY MANDATORY ELECTROCARDIOGRAPHY SCREENING: A JAPANESE NATIONWIDE SURVEYMitani Yoshihide*[1], Sawada Hirofumi[1], Nakayama Tomotaka[2], Fukushima Hiroyuki[3], Kogaki Shigetoyo[4], Igarashi Takehiro[5], Ichida Fukiko[6], Ono Yasuo[7], Nakanishi Toshio[8], Doi Shozaburo[9], Ishikawa Shiro[10], Matsushima Masaki[11], Yamada Osamu[5], Saji Tsutomu[2]

[1]Mie University Graduate School of Medicine ~ Tsu ~ Japan, [2]Toho University Omori Medical Center ~ Tokyo ~ Japan, [3]Keio University School of Medicine ~ Tokyo ~ Japan, [4]Osaka University School of Medicine ~ Osaka ~ Japan, [5]National Cerebral and Cardiovascular Center ~ Osaka ~ Japan, [6]Toyama University School of Medicine ~ Toyama ~ Japan, [7]Shizuoka Children’s Hospital ~ Shizuoka ~ Japan, [8]Tokyo Women’s Medical University ~ Tokyo ~ Japan, [9]Tokyo Medical and Dental University ~ Tokyo ~ Japan, [10]Fukuoka Children’s Hospital ~ Fukuoka ~ Japan, [11]Social Insurance Chukyo Hospital ~ Nagoya ~ Japan



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POSTER SESSIONS

Tuesday, February 27, 2018PATHOLOGY AND PATHOBIOLOGYA10 PAH-MIMICKING CHIP TO ELUCIDATE THE DISEASE

PATHOGENESIS AND SCREEN ANTI-PAH DRUGSFakhrul Ahsan*, Taslim A Al Hilal, Ali KeshavarzTexas Tech University Health Sciences Center ~ Amarillo ~ United States of America

A11 URIC ACID CAUSES EXCESSIVE PULMONARY ARTERIAL SMOOTH MUSCLE CELL PROLIFERATION VIA URATV1 UPREGULATION IN PULMONARY ARTERIAL HYPERTENSIONSatoshi Akagi*, Tamura Yuichi, Tu Ly, Phan Carole, Thuillet Raphaël, Sekine Ayumi, Huertas Alice, Humbert Marc, Guignabert ChristopheINSERM UMR_S 999 / University of Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre ~ France

A12 HEPARAN SULFATE IMBALANCE AND FINE STRUCTURAL MODIFICATIONS OF THEIR SULFATION PATTERNS IN LUNG ARE ASSOCIATED WITH FUNCTIONAL EFFECTS IN PRECAPILLARY PULMONARY HYPERTENSIONPatricia Albanese*[2], Sébastien Dumas[3], Benoit Ranchoux[3], Sara Shamdani[2], Sandrine Chantepie[2], Emilie Henault[2], David Montani[1], Barbara Girerd[1], Peter Dormuller[3], Elie Fadel[3], Philippe Dartevelle[3], Frederic Perros[3], Marc Humbert[1], Dulce Papy-Garcia[2], Sylvia Cohen-Kaminsky[1]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay. AP-HP Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre ~ 94270, Le Kremlin-Bicêtre ~ France, [2]Laboratoire CRRET/ EAC CNRS 7149, ERL CNRS 9215, Université Paris Est Créteil ~ 94010 Créteil ~ France, [3]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay ~ 92350, Le Plessis-Robinson, ~ France

A13 EXPERIMENTAL AND HUMAN PULMONARY VENO-OCCLUSIVE DISEASE: SIMILARITIES AND DIFFERENCESFabrice Antigny*[1], Esther Nossent[2], Melanie Lambert[1], Benoit Ranchoux[1], Audrey Courboulin[1], Barbara Girerd[3], Florent Soubrier[4], Florence Lecerf[1], Aurélie Hautefort[1], Harm Jan Bogaard[2], Elie Fadel[1], Gerald Simonneau[3], Anton Vonk Noordegraaf[2], Katrien Grünberg[2], Marc Humbert[1], David Montani[3], Peter Dorfmuller[1], Frederic Perros[1]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]Dept of Pulmonary diseases and Dept of Pathology, VU University Medical Center ~ Amsterdam ~ Netherlands, [3]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [4]INSERM UMR_S 956, Université Pierre and Marie Curie Université ~ Paris ~ France

A14 FORMINS MAY REGULATE ENDOTHELIAL TO MESCHYMAL TRANSITION VIA VASCULAR ENDOTHELIAL CADHERINMeghan Bernier*, Anil Bhatta, Lewis RomerJohns Hopkins School of Medicine ~ Baltimore ~ United States of America

A15 NEUTRALIZATION OF CXCL12 REVERSES PULMONARY VASCULAR REMODELING BY DECREASING PULMONARY ARTERIAL SMOOTH MUSCLE CELL ACCUMULATIONJennifer Bordenave*[1], Raphaël Thuillet[1], Ly Tu[1], Carole Phan[1], Gérald Simonneau[1], Alice Huertas[1], Marcel Hibert[2], Dominique Bonnet[2], Marc Humbert[1], Nelly Frossard[2], Christophe Guignabert[1]

[1]INSERM UMR_S999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre ~ France, [2]UMR 7200 CNRS-Université de Strasbourg / LabEx MEDALIS, Faculté de Pharmacie ~ Illkirch ~ France

A16 COMPREHENSIVE CHARACTERIZATION OF MESENCHYMAL STEM CELLS IN PAHKyunghee Byun*[4], Hanul Choi[4], Seyeon Oh[4], Duk-Kyung Kim[1], Duk-Kyung Kim[2], Byeong-Ju Lee[2], Jeongwon Ryu[4], Hae Ok Jung[3], Kevin Chung[4], Hanul Choi[4]

[1]Department of Cardiology, Sejong General Hspital ~ Bucheon ~ Korea, Republic of, [2]Department of Cardiovascular Medicine, Gachon University Gil Medical Center ~ Incheon ~ Korea, Republic of, [3]Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of, [4]Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute ~ Incheon ~ Korea, Republic of

A17 INDOLEAMINE-2,3-DIOXYGENASE AS A POTENTIAL THERAPEUTIC TARGET OF PULMONARY HYPERTENSIONZongye Cai*, Richard Wb Van Duin, Dirk Jan Duncker, Daphne MerkusErasmus MC ~ Rotterdam ~ Netherlands

A18 APELIN-13 CO-TREATMENT WITH UMBILICAL CORD BLOOD-DERIVED MESENCHYMAL STEM CELLS IMPROVES ENGRAFTED CELL SURVIVAL AND INHIBITS MACROPHAGE ACTIVATION IN PULMONARY ARTERIAL HYPERTENSION MURINE MODELSeungbum Choi*[1], Byeong-Ju Lee[2], Seyeon Oh[1], Kuk Hui Son[1], Duk-Kyung Kim[2], Hanul Choi[2], Jeongwon Ryu[3], Hae Ok Jung[4], Kyunghee Byun[1], Kevin Chung[1]

[1]Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute ~ Incheon ~ Korea, Republic of, [2]Department of Cardiovascular Medicine, Gachon University Gil Medical Center ~ Incheon ~ Korea, Republic of, [3]Advenced Medical Technology Laboratory Healcerion Co., Ltd ~ Seoul ~ Korea, Republic of, [4]Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of



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Tuesday, February 27, 2018PATHOLOGY AND PATHOBIOLOGYA19 NMDA-TYPE GLUTAMATE RECEPTOR ACTIVATION PROMOTES

VASCULAR REMODELING AND PULMONARY ARTERIAL HYPERTENSIONSylvia Cohen-Kaminsky*[1], Sébastien J Dumas[2], Gilles Bru-Mercier[2], Audrey Courboulin[2], Marceau Quatredeniers[2], Catherine Rucker-Martin[2], Fabrice Antigny[2], Morad K Nakhleh[2], Benoit Ranchoux[2], Elodie Gouadon[2], Maria Candida Vinhas[2], Matthieu Vocelle[2], Nicolas Raymond[2], Peter Dorfmüller[2], Elie Fadel[2], Frédéric Perros[2], Marc Humbert[1],[1]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Plessis-Robinson F-92350, AP-HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre F-94270, France ~, [2]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Plessis Robinson, F-92350 ~ France

A20 RASSF1A REGULATES HIF-1: TRIGGERING A FEED FORWARD LOOP IN HYPOXIA DRIVEN PULMONARY HYPERTENSIONSwati Dabral*[1], Christian Muecke[1], Rajkumar Savai[1], Chanil Valsarajan[1], Astrid Wietelmann[1], Gregg Semenza[3], Christos Samakovalis[2], Norbert Weissmann[2], Friedrich Grimminger[2], Werner Seeger[2], Reinhard Dammann[2], Soni Savai Pullamsetti[1]

[1]Max-Planck Insitute for heart and lung research ~ Bad Nauheim ~ Germany, [2]

University of giessen ~ Giessen ~ Germany, [3]Johns Hopkins University School of Medicine ~ Baltimore ~ United States of America

A21 INFLUENCE OF 16ALPHA-OHE2 ON MIGRATION AND ARYL HYDROCARBON RECEPTOR SIGNALLING IN BLOOD OUTGROWTH ENDOTHELIAL CELLS IN PAH.Nina Denver*[1], Craig Docherty[1], Katie Yates Harvey[1], Ruth Andrew[2], Natalie Homer[2], Nicholas Morrell[3], Margaret Maclean[1]

[1]University of Glasgow ~ Glasgow ~ United Kingdom, [2]University of Edinburgh ~ Edinburgh ~ United Kingdom, [3]University of Cambridge ~ Cambridge ~ United Kingdom

A22 A MEASUREMENT OF THE COMMON CAROTID ARTERY IN PATIENTS WITH PULMONARY HYPERTENSIONGunnar Einarsson*[2], Dan Henrohn[2], Frida Ulander[2], Tord Naessén[1], Marita Larsson[1], Gerhard Wikström[2]

[1]Department of Women’s and Children’s Health, Obstetrics and Gynaecology, Uppsala University Hospital, Uppsala ~ Uppsala ~ Sweden, [2]Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden ~ Uppsala ~ Sweden

A23 HISTONE DEACETYLASE 7 MEDIATES HYPOXIA-INDUCED MITOCHONDRIAL REPROGRAMING IN PULMONARY HYPERTENSION AND CANCERElisabetta Gamen*[1], Prakash Chelladurai[1], Werner Seeger[2], Soni Savai Pullamsetti[1]

[1](1) Max-Planck Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, [2]

Universities of Giessen and Marburg Lung Center (UGMLC) ~ Giessen ~ Germany

A24 COMPLEMENTARY AND INTEGRATED VALUE OF SIX-MINUTE WALK TEST, VE/VCO2 SLOPE AND RIGHT ATRIAL STRAIN IN EARLY DETECTION OF FUNCTIONAL IMPAIRMENT AND VASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTSMiriam Gravellone*, Ailia Giubertoni, Jacopo Zanaboni, Cristina Piccinino, Paolo Nicola MarinoClinical Cardiology, “Maggiore della Carità” Hospital ~ Novara ~ Italy

A25 BIOMARKER DISCOVERY IN PULMONARY ARTERIAL HYPERTENSION: EXERCISE TRAINING, OR NIGHTLY OXYGENGabriele Grunig*[1], Christina Eichstaedt[3], Nedim Durmus[1], Stéphanie Saxer[4], Konrad E Bloch[4], Sylvia Ulrich[4], Ekkehard Grünig[3], Serhiy Pylawka[2]

[1]NYU School of Medicine ~ New York ~ United States of America, [2]Mirna Analytics LLC ~ New York ~ United States of America, [3]Thoraxclinic at the University Clinic Heidelberg ~ Heidelberg ~ Germany, [4]University of Zurich ~ Zurich ~ Switzerland

A26 CHARACTERIZATION OF RATS MUTATED IN BMPR2: THE MAIN GENETIC RISK FACTOR FOR PAHAurélie Hautefort*[1], Catherine Rucker-Martin[1], Boris Manoury[2], Melanie Lambert[1], Angele Boet[1], Florence Lecerf[1], Peter Dorfmüller[1], Séverine Ménoret[3], Laurent Tesson[3], Igniacio Anegon[3], David Montani[4], Barbara Girerd[4], Marc Humbert[4], Fabrice Antigny[1], Frederic Perros[1]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]Inserm, UMR S1180, Faculté de Pharmacie, Université Paris Sud ~ Châtenay-Malabry ~ France, [3]INSERM UMR 1064-ITUN; CHU de Nantes ~ Nantes ~ France, [4]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France



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Tuesday, February 27, 2018PATHOLOGY AND PATHOBIOLOGYA27 PROPOSAL OF CLINICAL DIAGNOSTIC CRITERIA FOR

PULMONARY VENO-OCCLUSIVE DISEASE (PVOD) BASED ON THE PVOD REGISTRY STUDY IN JAPANHatsue Ishibashi-Ueda*[1], Keiko Ohta-Ogo[1], Seiichiro Sakao[2], Nobuhiro Tanabe[3], Teruaki Oka[4], Masanori Kitaichi[6], Norifumi Nakanishi[5], Toru Satoh[7], Hiromi Matsubara[8], Koichiro Tatsumi[2]

[1]Department of Pathology, National Cerebral and Cardiovascular Center, ~ Suita, Osaka ~ Japan, [2]Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [3]Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [4]

Department of Pathology,Kanto Central Hospital ~ Tokyo ~ Japan, [5]Department of Cardiovascular Medicine, Minami-Osaka Hospital ~ Osaka ~ Japan, [6]Department of Pathology, National Hospital Organization Minami Wakayama Medical Center ~ Tanabe, Wakayama ~ Japan, [7]Department of Cardiology, Kyorin University School of Medicine ~ Mitaka, Tokyo ~ Japan, [8]Department of Clinical Science, National Hospital Organization Okayama Medical Center ~ Okayama ~ Japan

A28 SELENOPROTEIN P PROMOTES THE DEVELOPMENT OF PULMONARY ARTERIAL HYPERTENSION -A POSSIBLE NOVEL THERAPEUTIC TARGET-Nobuhiro Kikuchi*[1], Kimio Satoh[1], Ryo Kurosawa[1], Nobuhiro Yaoita[1], Mohammad Elias-Al-Mamun[1], Mohammad Abdul Hai Siddique[1], Junichi Omura[1], Taijyu Satoh[1], Masamichi Nogi[1], Shinichiro Sunamura[1], Satoshi Miyata[1], Yoshiro Saito[2], Yasushi Hoshikawa[3], Yoshinori Okada[4], Hiroaki Shimokawa[1]

[1]Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan, [2]Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University ~ Kyoto ~ Japan, [3]Department of Thoracic Surgery, Fujita Health University School of Medicine ~ Aichi ~ Japan, [4]Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University ~ Sendai ~ Japan

A29 ALTERED BMP SIGNALING BY ENDOTHELIN-1 TO ACCELERATE PROLIFERATION OF SMOOTH MUSCLE CELLSHidekazu Maruyama*[2], Satoshi Sakai[1], Kazutaka Aonuma[1]

[1]University of Tsukuba ~ Tsukuba ~ Japan, [2]Moriya Daiichi General Hospital ~ Moriya ~ Japan

A30 SMOOTH MUSCLE PRIMES ENDOTHELIUM FOR REGENERATION BY LINKING METABOLISM TO EPIGENETICSKazuya Miyagawa*, Minyi Shi, Pin-I Chen, Jan Hennigs, Zhixin Zhao, Mouer Wang, Caiyun Li, Toshie Saito, Shalina Taylor, Silin Sa, Aiqin Cao, Lingli Wang, Michael Snyder, Marlene RabinovitchStanford Universtiy School of Medicine ~ Stanford ~ United States of America

A31 COMPARATIVE PHYSIOLOGICAL EVALUATION OF THE STATUS OF PULMONARY HEALTH IN YOUNG SMOKERS AND NON-SMOKERS Natalia Mokina*, Vasily Pyatin, Egor MokinSamara State Medical University ~ Samara ~ Russian Federation

A32 SCREENING OF AUTOANTIBODIES IN PATIENT WITH CHIRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION AND ITS VALIDATION IN PATIENT WITH PULMONARY HYPERTENSIONAkira Naito*[1], Tanabe Nobuhiro[2], Hiwasa Takaki[3], Jujo Takayuki[2], Sugiura Toshihiko[1], Sakao Seiichiro[1], Tatsumi Koichiro[1]

[1]Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [2]Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [3]Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan

A33 PULMONARY VASCULAR REMODELING PATTERNS AND EXPRESSION OF GCN2 IN PULMONARY VENO-OCCLUSIVE DISEASEEsther Nossent*[1], Antigny Fabrice[2], David Montani[3], Harm Jan Bogaard[1], Maria-Rosa Ghigna[4], Mélanie Lambert[2], Vincent Thomas De Montpréville[4], Barbara Girerd[3], Xavier Jaïs[3], Laurent Savale[3], Olaf Mercier[5], Elie Fadel[5], Florent Soubrier[6], Olivier Sitbon[3], Gérald Simonneau[3], Anton Vonk Noordegraaf[1], Marc Humbert[3], Frédéric Perros[2], Peter Dorfmüller[4]

[1]Department of Pulmonary Diseases, VU University Medical Center, Institute for Cardiovascular Research ~ Amsterdam ~ Netherlands, [2]INSERM UMR_S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies, Hôpital Marie Lannelongue ~ Paris ~ France, [3]National Reference Center of Pulmonary Hypertension, Department of Pulmonology and Intensive Care Unit for Respiratory Diseases, Hôpital Bicêtre, AP-HP, Kremlin-Bicêtre ~ Paris ~ France, [4]Department of Pathology, Hôpital Marie Lannelongue ~ Paris ~ France, [5]Department of Thoracic and Vascular Surgery, Hôpital Marie Lannelongue ~ Paris ~ France, [6]Department of Clinical Genetics, hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris and UMR_S 1166-ICAN, INSERM, UPMC Sorbonne Universités ~ Paris ~ France

A34 WIDE COMPARATIVE STUDY ON ANTIPROLIFERATIVE VS VASODILATOR EFFECTS OF DRUGS USED FOR PULMONARY HYPERTENSION IN RAT AND HUMAN ARTERIESFrancisco Perez-Vizcaino*[1], Daniel Morales-Cano[1], Bianca Barreira[2], Laura Moreno[2], Joan A Barbera[2], Angel Cogolludo[1]

[1]Universidad Complutense ~ Madrid ~ Spain, [2]Ciberes ~ Madrid ~ Spain



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POSTER SESSIONS

Tuesday, February 27, 2018PATHOLOGY AND PATHOBIOLOGYA35 GUT-LUNG CONNECTION IN PULMONARY ARTERIAL

HYPERTENSIONFrederic Perros*[1], Benoit Ranchoux[1], Amélie Bigorgne[2], Aurélie Hautefort[1], Barbara Girerd[3], Olivier Sitbon[3], David Montani[3], Marc Humbert[3], Colas Tcherakian[4]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]UPMC UMRS CR7 – Inserm U1135 – CNRS ERL 8255 ~ Paris ~ France, [3]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [4]Service de Pneumologie, Hôpital Foch ~ Suresnes ~ France

A36 DASATINIB INCREASES ENDOTHELIAL PERMEABILITY LEADING TO PLEURAL EFFUSION Carole Phan*[1], Etienne-Marie Jutant[1], Ly Tu[1], Raphael Thuillet[1], Andrei Seferian[1], David Montani[1], Alice Huertas[1], Jan Van Bezu[2], Fabian Breijer[2], Anton Vonk Noordegraaf[3], Marc Humbert[1], Jurjan Aman[4], Christophe Guignabert[1]

[1]INSERM UMR_S999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre ~ France, [2]VU University Medical Center, Department of Physiology ~ Amsterdam ~ Netherlands, [3]Department of Pulmonary Disease, Institute of Cardiovascular Research ~ Amsterdam ~ Netherlands, [4]VU University Medical Center, Department of Physiology and Department of Pulmonary Disease, Institute of Cardiovascular Research ~ Amsterdam ~ Netherlands

A37 SHOULD WE CONSIDER PIRFENIDONE IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION?Paul-Benoit Poble*, Ghigna Maria Rosa, Phan Carole, Tu Ly, Bordenave Jennifer, Cumont Amélie, Thuillet Raphaël, Huertas Alice, Humbert Marc, Dorfmüller Peter, Guignabert ChristopheINSERM UMR_S 999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre ~ France

A38 LUNG CANCER–ASSOCIATED PULMONARY HYPERTENSION: ROLE OF MICROENVIRONMENTAL INFLAMMATION BASED ON TUMOR CELL-IMMUNE CELL CROSSTALKSoni Pullamsetti*[1], Rajkumar Savai[1], Baktybek Kojonazarov[2], Samantha Storn[1], Henning Gall[2], Ylia Salazar[1], Janine Wolf[3], Andreas Weigert[4], Nefertiti El-Nikhely[1], Ardeschir Ghofrani[2], Gabriele Krombach[3], Ludger Fink[5], Stefan Gattenlöhner[6], Ulf Rapp[1], Ralph Schermuly[2], Friedrich Grimminger[2], Werner Seeger[2]

[1]Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodeling, member of the German Center for Lung Research (DZL) ~ Bad Nauheim ~ Germany, [2]Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen ~ Germany, [3]Department of Radiology, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen ~ Germany, [4]

Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt ~ Frankfurt ~ Germany, [5]Institute of Pathology and Cytology, UEGP ~ Wetzlar ~ Germany, [6]

Department of Pathology, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen ~ Germany

A39 MITOMYCIN C INDUCES PULMONARY HYPERTENSION AND PATHOLOGIC SIGNS OF PULMONARY VASCULAR OCCLUSIVE DISEASE IN RABBITSRozenn Quarck*[1], Allard Wagenaar[2], Birger Tielemans[2], Aurélie Hautefort[3], Catharina Belge[1], Fabrice Antigny[3], David Montani[3], Marion Delcroix[1], Frédéric Perros[3]

[1]KU Leuven and University Hospitals Leuven ~ Leuven ~ Belgium, [2]KU Leuven ~ Leuven ~ Belgium, [3]INSERM and University Paris-Sud ~ Le Plessis Robinson ~ France

A40 TRICHLOROETHYLENE-INDUCED PERMEABILITY OF THE PULMONARY VASCULAR ENDOTHELIUM: A ROLE IN THE DEVELOPMENT OF PULMONARY VENO-OCCLUSIVE DISEASE? Marianne Riou*[1], Morad Nakhleh[2], Florence Lecerf[2], Marc Humbert[1], David Montani[1], Frederic Perros[2]

[1]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôpital de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France

A41 BLOCKADE OF ENDOTHELIN RECEPTOR TYPE B PROMOTE APOPTOSIS IN HUMAN PULMONARY ARTERIAL SMOOTH MUSCLE CELLSSatoshi Sakai*, Hidekazu Maruyama, Taizo Kimura, Junya Honda, Kazuya Otsu, Satoshi Homma, Takashi Miyauchi, Kazutaka AonumaUniversity of Tsukuba ~ Tsukuba ~ Japan



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POSTER SESSIONS

Tuesday, February 27, 2018PATHOLOGY AND PATHOBIOLOGYA42 SHEAR-MEDIATED ERYTHROCYTE NITRIC OXIDE PRODUCTION

IS DIFFERENTIALLY REGULATED IN PATIENTS WITH SICKLE CELL DISEASE Jacqueline Szmuszkovicz*, Silvie Suriany, Derek Ponce, Jon DetterichChildren’s Hospital Los Angeles ~ Los Angeles ~ United States of America

A43 THE SIX-TRANSMEMBRANE PROTEIN STAMP2 PROTECTS FROM PULMONARY HYPERTENSION VIA ACTIONS IN MONONUCLEAR CELLSHenrik Ten Freyhaus*, Mahreen Batool, Eva Berghausen, Marius Vantler, Stephan RosenkranzKlinik III for Internal Medicin, Heart Center of the University of Cologne ~ Cologne ~ Germany

A44 PHENOTYPING OF PULMONARY ARTERIAL ENDOTHELIAL CELLS ISOLATED FROM PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION AT DIAGNOSISBirger Tielemans*[1], Allard Wagenaar[1], Mathias Leys[2], Catharina Belge[2], Marion Delcroix[2], Rozenn Quarck[1]

[1]KU Leuven ~ Leuven ~ Belgium, [2]UZ leuven ~ Leuven ~ Belgium

A45 BMPRII DRIVEN RESPONSE OF ENDOTHELIAL INTEGRITY AND ANGIOGENESIS IN HUMAN LUNG MICROVASCULAR ENDOTHELIAL CELLSBirger Tielemans*[1], Rik Gijsbers[1], Annelies Michiels[1], Allard Wagenaar[1], Richard Farré Marti[1], Catharina Belge[2], Marion Delcroix[2], Rozenn Quarck[1]

[1]KU Leuven ~ Leuven ~ Belgium, [2]UZ leuven ~ Leuven ~ Belgium

A46 CONTRIBUTION OF BMP9 TO PULMONARY ARTERIAL HYPERTENSION: ROLE OF ENDOTHELIN-1Ly Tu*[3], Ayumi Sekine[3], Christine Mallet[2], Jennifer Bordenave[3], Agnès Castan[2], Raphael Thuillet[3], Carole Phan[3], Paul-Benoit Poble[3], Jean-Jacques Feige[1], Alice Huertas[3], Marc Humbert[3], Sabine Bailly[2], Christophe Guignabert[3]

[1]Inserm U1036 ~ Grenoble ~ France, [2]Inserm UMR_S 1036 ~ Grenoble ~ France, [3]

Inserm UMR_S 999 ~ Paris ~ France

A47 LONG NONCODING RNA TYKRIL PLAYS A ROLE IN PULMONARY HYPERTENSION BY CONTROLLING THE P53 MEDIATED REGULATION OF PDGFRßChanil Valasarajan*[1], Christoph Zehendner[2], Serge Thal[3], Astrid Werner[2], Jes-Niels Boeckel[2], Florian Bischoff[2], David John[2], Tyler Weirick[2], Simone Glaser[2], Oliver Rossbach[4], Nicolas Jaé[2], Shemsi Demolli[2], Regina Hummel[3], Karl-Friedrich Kreitner[5], Christian Möllmann[3], Katharina Michalik[2], Wei Chen[6], Werner Seeger[1], Shizuka Uchida[2], Andreas Zeiher[7], Stefanie Dimmeler[2], Soni Pullamsetti[1]

[1]Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodeling, member of 13 the German Center for Lung Research (DZL) ~ Bad Nauheim ~ Germany, [2]Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt am Main ~ Frankfurt am Main ~ Germany, [3]

Department of Anesthesiology, University Medical Center Mainz ~ Mainz ~ Germany, [4]Institute of Biochemistry, University of Giessen ~ Giessen ~ Germany, [5]Department of Radiology, University Medical Center Mainz ~ Mainz ~ Germany, [6]Department of Biology, Southern University of Science and Technology ~ Guangdong ~ China, [7]ZIM III, Department of Cardiology, Goethe University ~ Frankfurt am Main ~ Germany

A48 SEX HORMONE PROFILES PREDICT THE RISK AND SEVERITY OF DISEASE IN POST-MENOPAUSAL WOMEN WITH PULMONARY ARTERIAL HYPERTENSIONCorey Ventetuolo*[1], Grayson Baird[1], R Graham Barr[2], David Bluemke[3], Andrew Foderaro[1], Jason Fritz[4], Nicholas Hill[5], James Klinger[1], Joao Lima[6], Pamela Ouyang[6], Harold Palevsky[4], Amy Palmisciano[7], Diane Pinder[4], Ioana Preston[5], Thomas Walsh[7], Kari Roberts[5], Steven Kawut[4]

[1]Brown University ~ Providence ~ United States of America, [2]Columbia University ~ New York ~ United States of America, [3]National Institutes of Health ~ Bethesda ~ United States of America, [4]University of Pennsylvania ~ Philadelphia ~ United States of America, [5]Tufts University ~ Boston ~ United States of America, [6]Johns Hopkins ~ Baltimore ~ United States of America, [7]Rhode Island Hospital ~ Providence ~ United States of America

A49 PLATELET FUNCTION ABNORMALITIES IN PULMONARY HYPERTENSION Eleni Vrigkou*, Iraklis Tsangaris, Argyrios Tsantes, Dimitrios Konstantonis, Athanasios Pappas, Frantzeska Frantzeskaki, Michalis Rizos, Stylianos Orfanos, Apostolos ArmaganidisAttikon University Hospital ~ Athens ~ Greece

A50 RECEPTOR TYROSINE KINASE SIGNALING DRIVING “PSEUDO-MALIGNANT” LUNG VASCULAR REMODELING - THERAPEUTIC EXPLOITATIONNaga Dinesh Reddy Yerabolu*Justus Liebig university Giessen ~ Giessen ~ Germany



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POSTER SESSIONS

Tuesday, February 27, 2018GENETICS AND GENOMICS A51 THE UNITED STATES PULMONARY HYPERTENSION SCIENTIFIC

REGISTRY (USPHSR): DESIGN AND INITIAL BASELINE CHARACTERISTICSDavid Badesch*[1], Adaani Frost[4], Eric Austin[2], Jessica Badlam[1], Ray Benza[5], Wendy K. Chung[6], Harrison Farber[7], Kathy Feldkircher[9], Bill Nichols[8], Abby Poms[10], Chang Yu[2], C Greg Elliott[3]

[1]University of Colorado ~ Denver ~ United States of America, [2]Vanderbilt University ~ Nashville ~ United States of America, [3]Intermountain Medical Center, University of Utah ~ Murray ~ United States of America, [4]Houston Methodist Hospital and Weill Cornell Medical College ~ Houston ~ United States of America, [5]Allegheny Hospital ~ Pittsburgh ~ United States of America, [6]Columbia University ~ New York ~ United States of America, [7]Boston University ~ Boston ~ United States of America, [8]Cincinatti Children’s Hospital ~ Cincinatti ~ United States of America, [9]ESquared Trials ~ Half Moon Bay ~ United States of America, [10]ESquared Trials ~ United States of America

A52 DISCOVERY OF VASCULAR CELL-SPECIFIC EPIGENOMIC SIGNATURES, NOVEL TRANSCRIPTION FACTORS AND SIGNALING NETWORKS IN HUMAN PULMONARY ARTERIAL HYPERTENSIONPrakash Chelladurai*[1], Carsten Künne[1], Christine Weber[2], René Reiner Nötzold[2], Mario Schmoranzer[1], Mario Looso[1], Uta-Maria Bauer[2], Werner Seeger[1], Soni Savai Pullamsetti[1]

[1]Max-Planck Institute for Heart and Lung Research, Bad Nauheim ~ 61231 ~ Germany, [2]Institute of Molecular Biology and Tumor Research ~ Marburg ~ Germany

A53 PREVALENCE AND CLINICAL FEATURES OF BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 MUTATION IN KOREAN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTSWook-Jin Chung*[1], Jun Soo Lee[2], Seungbum Choi[1], Seyeon Oh[1], Hanul Choi[2], Kyung-Hee Kim[3], Kuk Hui Son[1], Hae Ok Jung[4], Jeongwon Ryu[1], Kyunghee Byun[1]

[1]Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute ~ Incheon ~ Korea, Republic of, [2]Department of Cardiovascular Medicine, Gachon University Gil Medical Center ~ Incheon ~ Korea, Republic of, [3]Department of Cardiology, Sejong General Hspital ~ Bucheon ~ Korea, Republic of, [4]Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of

A54 FIRST IDENTIFICATION OF KRÜPPEL-LIKE FACTOR 2 MUTATION IN HERITABLE PULMONARY ARTERIAL HYPERTENSIONChristina Eichstaedt*[1], Jie Song[1], Rebecca Rodríguez Viales[2], Zixuan Pan[1], Nicola Benjamin[1], Christine Fischer[3], Marius Hoeper[4], Silvia Ulrich[5], Katrin Hinderhofer[3], Ekkehard Grünig[1]

[1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelb ~ Heidelberg ~ Germany, [2]European Molecular Biology Laboratory ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Germany, [4]Hannover Medical School, Clinic for Pneumology ~ Hannover ~ Germany, [5]

Clinic of Pulmonology, University Hospital Zurich ~ Zurich ~ Switzerland

A55 COMMON GENETIC BASIS FOR PULMONARY ARTERIAL HYPERTENSION AND HIGH ALTITUDE PULMONARY EDEMAChristina Eichstaedt*[1], Heimo Mairbäurl[2], Jie Song[1], Nicola Benjamin[1], Christine Fischer[3], Katrin Hinderhofer[3], Ekkehard Grünig[1]

[1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]Medical Clinic VII, Sports Medicine, University of Heidelberg and Translational Lung Research Centre Heidelberg (TLRC), German Centre for Lung Research (DZL) ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Germany

A56 CLINICAL MANIFESTATION OF HEREDITARY PULMONARY ARTERIAL HYPERTENSION BY A “SECOND HIT” MUTATION IN THE GENES BMPR2 AND EIF2AK4Christina Eichstaedt*[1], Jie Song[1], Rebecca Rodríguez Viales[2], Nicola Benjamin[1], Satenik Harutyunova[1], Christine Fischer[3], Katrin Hinderhofer[3], Ekkehard Grünig[1]

[1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]European Molecular Biology Laboratory ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Germany



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Tuesday, February 27, 2018GENETICS AND GENOMICS A57 LANDSCAPE OF MUTATIONS FOUND BY GENE PANEL ROUTINE

SEQUENCING FOR PULMONARY HYPERTENSION Mélanie Eyries*[1], Anne Leroy[1], Barbara Girerd[2], David Montani[2], Marilyne Levy[3], Damien Bonnet[3], Arnaud Bourdin[4], Romain Tresorier[5], Ari Chaouat[6], Vincent Cottin[7], Céline Sanfiorenzo[8], Grégoire Prevot[9], Martine Reynaud-Gaubert[12], Claire Dromer[10], Ali Houeijeh[11], Marc Humbert[2], Florent Soubrier[1]

[1]Département de Génétique, Hôpital Pitié-Salpétrière, APHP ~ PARIS ~ France, [2]Centre de référence de l’hypertension pulmonaire sévère, Service de pneumologie, Hôpital Bicêtre, APHP ~ Le Kremlin Bicêtre ~ France, [3]M3C-Cardiologie pédiatrique, Hôpital Necker-enfants malades, APHP ~ PARIS ~ France, [4]Département de pneumologie et addictologie, CHU Arnaud de Villeneuve ~ Montpellier ~ France, [5]Service de cardiologie maladies vasculaires, CHU Gabriel Montpied ~ Clermont-Ferrand ~ France, [6]Département de pneumologie, CHRU Nacy-Université de Lorraine ~ Vandoeuvre-les-nancy ~ France, [7]Service de pneumologie, CHU Lyon HCL-GH Est-Hôpital Louis Pradel ~ Bron ~ France, [8]Service de pneumologie, Hôpital Pasteur, CHU Nice ~ Nice ~ France, [9]Service de pneumologie, Hôpital Larrey, CHU toulouse ~ Toulouse ~ France, [10]Service de pneumologie, CHU de Bordeaux, Hôpital Haut-lévêque ~ Bordeaux ~ France, [11]

Service de cardiologie infantile et congénitale, CHRU Lille-Hôpital cardiologique ~ Lille ~ France, [12]Service de pneumologie, CHU Nord de Marseille, AP-HM, Aix- Marseille Université ~ Marseille ~ France

A58 NOVEL CAUSATIVE GENES FOR HERITABLE PULMONARY ARTERIAL HYPERTENSIONStefan Gräf*[1], Matthias Haimel[1], Marta Bleda[1], Charaka Hadinnapola[1], Wei Li[1], Joshua Hodgson[1], Bin Liu[1], Richard M Salmon[1], Mark Southwood[2], Laura Southgate[3], Rajiv D Machado[4], Jennifer M Martin[1], Carmen M Treacy[1], Katherine Yates[1], Louise C Daugherty[1], Olga Shamardina[1], Deborah Whitehorn[1], Simon Holden[5], Micheala A. Aldred[6], Harm J Bogaard[7], Colin Church[8], Gerry Coghlan[9], Robin Condliffe[11], Paul A Corris[14], Cesare Danesino[15], Mélanie Eyries[16], Henning Gall[18], Stefano Ghio[19], Hossein-Ardeschir Ghofrani[18], J Simon R Gibbs[20], Barbara Girerd[21], Arjan C Houweling[7], Luke Howard[10], Marc Humbert[21], David G Kiely[11], Gabor Kovacs[23], Robert V Mackenzie Ross[17], Shahin Moledina[22], David Montani[21], Michael Newnham[1], Andrea Olschewski[6], Horst Olschewski[6], Andrew J Peacock[8], Joanna Pepke-Zaba[2], Inga Prokopenko[10], Christopher J Rhodes[10], Laura Scelsi[19], Werner Seeger[18], Florent Soubrier[16], Jay Suntharalingam[17], Emilia Swietlik[1], Mark R Toshner[1], Anton Vonk Noordegraaf[7], Quintin Waisfisz[7], John Wharton[10], Stephen J Wort[10], Nicole Soranzo[13], Willem H Ouwehand[1], Allan Lawrie[11], Paul D Upton[1], Richard C Trembath[12], Martin R Wilkins[10], Nicholas W Morrell[1]

[1]University of Cambridge ~ Cambridge ~ United Kingdom, [2]Papworth Hospital ~ Papworth ~ United Kingdom, [3]Molecular and Clinical Sciences Research Institute, St George’s, University of London ~ London ~ United Kingdom, [4]University of Lincoln ~ Lincoln ~ United Kingdom, [5]Addenbrooke’s Hospital ~ Cambridge ~ United Kingdom, [6]Cleveland Clinic ~ Cleveland, Ohio ~ United States of America, [7]VU University Medical Center ~ Amsterdam ~ Netherlands, [8]Golden Jubilee National Hospital ~ Glasgow ~ United Kingdom, [9]Royal Free Hospital ~ London ~ United Kingdom, [10]

Imperial College London ~ London ~ United Kingdom, [11]Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital ~ Sheffield ~ United Kingdom, [12]King’s College London ~ London ~ United Kingdom, [13]Wellcome Trust Sanger Institute ~ Hinxton ~ United Kingdom, [14]University of Newcastle ~ Newcastle ~ United Kingdom, [15]Department of Molecular Medicine, University of Pavia ~ Pavia ~ Italy, [16]Département de génétique, hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, and UMR_S 1166-ICAN, INSERM, UPMC Sorbonne Universités ~ Paris ~ France, [17]Royal United Hospitals Bath NHS Foundation Trust ~ Bath ~ United Kingdom, [18]University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL) and of the Excellence Cluster Cardio-Pulmonary System (ECCCPS) ~ Giessen ~ Germany, [19]Fondazione IRCCS Policlinico San Matteo ~ Pavia ~ Italy, [20]

National Heart & Lung Institute, Imperial College London ~ London ~ United Kingdom, [21]Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP-HP, Service de Pneumologie, Centre de référence de l’hypertension pulmonaire; INSERM UMR_S 999, Hôpital Bicêtre, Le Kremlin-Bicêtre ~ Paris ~ France, [22]Great Ormond Street Hospital ~ London ~ United Kingdom, [23]Ludwig Boltzmann Institute for Lung Vascular Research ~ Graz ~ Austria



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Tuesday, February 27, 2018GENETICS AND GENOMICS A59 A SENSITIVE RESPONSE TO HYPOXIA IN PULMONARY ARTERY

IN HIGH-ALTITUDE PULMONARY EDEMA SUSCEPTIBLE SUBJECTS UNDER A GENETIC BACKGROUND OF VARIATIONS IN THE EGLN1 GENENobumitsu Kobayashi*, Fumiya Kinota, Yunden Droma, Toshimichi Horiuchi, Atuhito Ushiki, Masanori Yasuo, Hiroshi Yamamoto, Masao Ota, Masayuki HanaokaShinshu University School of Medicine ~ Matsumoto ~ Japan

A60 KCNK3 CHANNEL INACTIVATION LEADS TO PULMONARY VASCULAR ALTERATIONS IN RATMélanie Lambert*[1], Aurélie Hautefort[1], Boris Manoury[2], David Montani[1], Marc Humbert[1], Frédéric Perros[1], Fabrice Antigny[1]

[1]U999 ~ Le plessis Robinson ~ France, [2]U1180 ~ Chatenay Malabry ~ France

A61 ENHANCED EXPRESSION OF ENDOTHELIN-2, AN ISOPEPTIDE OF ENDOTHELIN-1, BY HYPOXIA IN LUNGS: POSSIBLE ROLE IN PULMONARY HYPERTENSIONYoko Suzuki*[1], Ikeda Koji[2], Miyagawa Kazuya[2], Tamada Naoki[1], Nakayama Kazuhiko[1], Yanagisawa Masashi[3], Emoto Noriaki[1]

[1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine ~ Kobe ~ Japan, [2]Clinical Pharmacy, Kobe Pharmaceutical University ~ Kobe ~ Japan, [3]International Institute for Integrative Sleep Medicine, University of Tsukuba ~ Tsukuba ~ Japan

A62 THE EFFECTS OF BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 MUTATION ON RIGHT VENTRICULAR FUNCTION IN PULMONARY ARTERIAL HYPERTENSION AFTER OPTIMAL COMBINATION THERAPYHiraide Takahiro*[1], Murata Mitsushige[2], Kataoka Masaharu[1], Aimi Yuki[3], Isobe Sarasa[1], Kawakami Takashi[1], Moriyama Hidenori[1], Endo Jin[1], Itabashi Yuji[1], Gamou Shinobu[3], Fukuda Keiichi[1]

[1]Department of Cardiology, Keio University School of Medicine ~ Tokyo ~ Japan, [2]

Department of Laboratory Medicine, School of Medicine, Keio University ~ Tokyo ~ Japan, [3]Second Department of Internal Medicine, Kyorin University School of Medicine ~ Tokyo ~ Japan

PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATIONA63 INHIBITION OF NITRIC OXIDE SYNTHASE UNMASKS POTENT

VASOCONSTRICTION IN ESTABLISHED PULMONARY ARTERIAL HYPERTENSIONKohtaro Abe*, Mariko Tanaka, Hiroyuki TsutsuiKyushu University Graduate School of Medical Sciences ~ Fukuoka ~ Japan

A64 DIMINISHED RIGHT VENTRICULAR FUNCTION AT DIAGNOSIS OF PULMONARY HYPERTENSION IS ASSOCIATED WITH MORTALITY IN BRONCHOPULMONARY DYSPLASIA Gabriel Altit*, Shazia Bhombal, Jeffrey Feinstein, Theresa TacyStanford University ~ Palo Alto ~ United States of America

A65 THE OMEGA-3 EPA: DHA 6:1 FORMULATION PREVENTS THE MONOCROTALINE-INDUCED PULMONARY HYPERTENSION, PULMONARY ARTERY REMODELING AND ENDOTHELIAL DYSFUNCTION, AND RIGHT VENTRICULAR FAILURE IN RATSSaid Amissi*[1], Zahid Rasul Niazi[1], Mélanie Burban[1], Romain Kessler[2], Mathieu Canuet[3], Florence Toti[1], Laurent Monassier[4], Nelly Boehm[5], Cyril Auger[1], Ferhat Meziani[2], Valérie Schini-Kerth[1]

[1]UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, Université de Strasbourg ~ Strasbourg ~ France, [2]EA 7293, Stress vasculaire et tissulaire en transplantation, Fédération de médecine translationnelle de Strasbourg, Faculté de Pharmacie, université de Strasbourg ~ Strasbourg ~ France, [3]Pneumologie-addictologie clinique, 5101 Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg ~ Strasbourg ~ France, [4]EA 7296, Laboratoire de Neurologie et Pharmacologie cardiovasculaire, Fédération de médecine translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg ~ Strasbourg ~ France, [5]Institut d’histologie et INSERM U1119, Fédération de médecine translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg, France ~ Strasbourg ~ France



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Tuesday, February 27, 2018PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATIONA66 ALTERATION OF KCNK3 FUNCTION CONTRIBUTES TO RIGHT

VENTRICULAR DYSFUNCTIONS IN EXPERIMENTAL PULMONARY HYPERTENSION Fabrice Antigny*[1], Mélanie Lambert[1], Angèle Boet[1], Catherine Rucker-Martin[1], Véronique Capuano[1], Stéphane Hatem[2], Aurélie Hautefort[1], Jean-Baptiste Michel[3], Peter Dorfmüller[1], Elie Fadel[1], Tom Kotsimbos[4], Philippe Jourdon[1], David Montani[1], Frédéric Perros[1], Marc Humbert[1]

[1]INSERM U999 ~ LE PLESSIS ROBINSON ~ France, [2]UMRS-1166 INSERM ~ Paris ~ France, [3]INSERM UMRS 1148 ~ Paris ~ France, [4]Dept. Respiratory Medicine, Alfred Hospital ~ Melbourne ~ Australia

A67 IMPAIRED RIGHT VENTRICULAR O2 DELIVERY IS ASSOCIATED WITH REDUCED RIGHT VENTRICULAR RESERVE IN PULMONARY HYPERTENSION DURING EXERCISEZongye Cai*, Richard Wb Van Duin, Dirk Jan Duncker, Daphne MerkusErasmus MC ~ Rotterdam ~ Netherlands

A68 PULMONARY ARTERIAL VOLUME, A DETERMINANT OF RESERVOIR FUNCTION MAY MODULATE RIGHT VENTRICULAR PERFORMANCE IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONHao-Chih Chang*, Lu Dai-Yin, Sung Shih-HsienDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital ~ Taipei City ~ Taiwan

A69 ALTERED MYOCARDIAL ENERGY METABOLISM IN EXPERIMENTAL RIGHT VENTRICULAR FAILURE ON ACUTE AND CHRONIC INCREASED AFTERLOADLaurence Dewachter*[1], Asmae Belhaj[2], Benoit Rondelet[2], Francois Kerbaul[1], Serge Brimioulle[1], Robert Naeije[1], Céline Dewachter[1]

[1]Université Libre de Bruxelles ~ Brussels ~ Belgium, [2]Université Catholique de Louvain ~ Dinant ~ Belgium

A70 CORRELATION BETWEEN RIGHT VENTRICULAR FUNCTION ASSESSED BY ECHOCARDIOGRAPHY AND BY RIGHT HEART CATHETERIZATION AMONG PATIENTS WITH PULMONARY HYPERTENSIONJuan Farina*[1], Augusto Lavalle Cobo[1], Hector Gomez Santa Maria[1], Diego Crippa[1], Brenda Varela[3], Alfredo Hirschson Prado[2], Alejandro Nitsche[3], Angeles Barth[1], Victor Daru[1], Adrian Lescano[1]

[1]Finochietto Clinic ~ Buenos Aires ~ Argentina, [2]Hospital Rivadavia ~ Buenos Aires ~ Argentina, [3]Hospital Aleman ~ Buenos Aires ~ Argentina

A71 PULMONARY VASCULAR RESISTANCE AND COMPLIANCE RELATIONSHIP IN PULMONARY HYPERTENSION: DIRECT MEASUREMENTS VERSUS EMPIRIC FORMULAEChristian Gerges*[1], Mario Gerges[1], Pierre Fesler[2], Anna Maria Pistritto[3], David Celermajer[4], Irene Lang[1]

[1]Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna ~ Vienna ~ Austria, [2]PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, and Department of Internal Medicine, Lapeyronie Hospital ~ Montpellier ~ France, [3]Department of Internal Medicine, Division of Cardiology, Ferrarotto Hospital, University of Catania ~ Catania ~ Italy, [4]Department of Cardiology, Sydney Medical School, University of Sydney ~ Sydney ~ Australia

A72 MIR-21 REGULATED RIGHT VENTRICULAR REMODELING SECONDARY TO PULMONARY ARTERIAL PRESSURE OVERLOADChih-Hsin Hsu*[2], Hao-Chih Chang[1], Frederick Y Chen[4], Ronglih Liao[3]

[1]Chi-Mei Medical Center ~ Tainan ~ Taiwan, [2]Cheng Kung University Hospital ~ Tainan ~ Taiwan, [3]Brigham and Women’s Hospital ~ Boston ~ United States of America, [4]Tufts Medical Center ~ Boston ~ United States of America

A73 ACTIVATED CONVENTIONAL DENDRITIC CELLS AS DRIVERS IN THE PATHOPHYSIOLOGY OF IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION (IPAH)?Thomas Koudstaal*[1], Jennifer Van Hulst[1], Tridib Das[1], Peter Heukels[1], Daphne Merkus[2], Michiel De Raaf[2], Ingrid Bergen[1], Bogaard Harmjan[3], Caetano Reis E Sousa[4], Geert Van Loo[5], Rudi Hendriks[1], Karin Boomars[1], Mirjam Kool[1]

[1]Department of Pulmonary Medicine, Erasmus MC ~ Rotterdam ~ Netherlands, [2]

Department of Cardiology ~ Rotterdam ~ Netherlands, [3]Department of Pulmonary Medicine, VUmc ~ Amsterdam ~ Netherlands, [4]Cancer research Centre UK, The Francis Crick Institute ~ London ~ United Kingdom, [5]VIB ~ Ghent ~ Belgium

A74 EXERCISE HEMODYNAMIC PREDICTORS OF PEAK OXYGEN CONSUMPTION IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSIONEloara Machado Ferreira*, Carolina M S Messina, Rudolf K F Oliveira, Angelo X C Fonseca, Roberta P Ramos, Jaquelina S Ota-ArakakiFederal University of São Paulo (UNIFESP) ~ São Paulo ~ Brazil

A75 POTENTIAL ROLE OF THE ARYL HYDROCARBON RECEPTOR IN PAHMargaret Maclean*, Afshan Dean, Teja Gregorc, Craig DochertyUniversity of Glasgow ~ Glasgow ~ United Kingdom



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Tuesday, February 27, 2018PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATIONA76 OSTEOPONTIN IN RIGHT VENTRICULAR REMODELING

Argen Mamazhakypov*, Akylbek Sydykov, Xia Tian, Kabita Pradhan, Astrid Weiß, Werner Seeger, Norbert Weissmann, Ardeschir Ghofrani, Ralph SchermulyExcellence Cluster Cardio-Pulmonary System, University of Giessen ~ Giessen ~ Germany

A77 THE STIFFNESS OF THE PULMONARY ARTERY AS A MARKER OF RIGHT VENTRICULAR FUNCTION IN PATIENTS WITH PULMONARY HYPERTENSIONOlga Moiseeva*, Maria Simakova, Anton Rygkov, Aigun KyzymlyAlmazov National Medical Research Centre ~ Saint-Petersburg ~ Russian Federation

A78 THE CLINICAL VALUE OF ASSESSING RIGHT VENTRICULAR DIASTOLIC FUNCTION AFTER BALLOON PULMONARY ANGIOPLASTY IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONHidenori Moriyama*, Mitsushige Murata, Toshimitsu Tsugu, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Mai Kimura, Sarasa Isobe, Jin Endo, Takashi Kohno, Yuji Itabashi, Keiichi FukudaKeio University ~ Tokyo ~ Japan

A79 HIGH-SENSITIVE CARDIAC TROPONIN T LEVEL IS A SURROGATE MARKER FOR RV FUNCTIONAL RECOVERY AFTER SUCCESSFUL BALLOON PULMONARY ANGIOPLASTY IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONMitsushige Murata*, Toshimitsu Tsugu, Takahiro Hiraide, Hidenori Moriyama, Mai Kimura, Sarasa Isobe, Takashi Kawakami, Masaharu Kataoka, Takashi Kohno, Yuji Itabashi, Keiichi FukudaKeio University ~ Tokyo ~ Japan

A80 WNT-SIGNALING PATHWAY DRIVES RIGHT VENTRICULAR REMODELINGSreenath Reddy Nayakanti*[1], Aleksandra Tretyn[1], Swati Dabral[1], Mario Böhm[2], Baktybek Kojonazarov[2], Wiebke Janssen[1], Werner Seeger[1], Ralph Schermuly[2], Soni Savai Pullamsetti[1]

[1]Max-Planck-Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, [2]

Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) ~ Giessen ~ Germany

A81 THE RELATIONSHIP BETWEEN PULMONARY BLOOD FLOW AND PULMONARY MICROVASCULAR RECRUITMENT IN SUPINE EXERCISING HUMANSStylianos Orfanos*[2], David Langleben[1], Michele Giovinazzo[1], Robert Schlesinger[1], Fay Blenkhorn[1], John Catravas[3]

[1]Jewish General Hospital ~ Montreal ~ Canada, [2]Attikon Hospital ~ Athens ~ Greece, [3]Old Dominion University ~ Norfolk ~ United States of America

A82 REGIONAL INHOMOGENEITY OF RIGHT VENTRICULAR CONTRACTION DURING HYPOXIC BREATHING BUT NOT DURING EXERCISE IN HEALTHY SUBJECTSBeatrice Pezzuto*[1], Kevin Forton[2], Vitalie Faoro[2], Yoshiki Motoji[2], Roberto Badagliacca[3], Carmine Dario Vizza[3], Jean-Luc Vachiéry[5], Robert Naeije[4]

[1]Free University of Brussels-Dept of Exercise Physiology of the Faculty of Motor Sciences; Sapienza University of Rome - Dept. of Cardiovascular and Respiratory Sciences ~ Rome ~ Italy, [2]Free University of Brussels - Dept of Exercise Physiology of the Faculty of Motor Sciences ~ Brussels ~ Belgium, [3]Sapienza University of Rome - Dept of Cardiovascular and Respiratory Sciences ~ Rome ~ Italy, [4]Free University of Brussels - Dept of Exercise Physiology of the Faculty of Motor Sciences; Erasme Academic Hospital - Dept of Cardiology ~ Brussels ~ Belgium, [5]Erasme Academic Hospital of Brussels, Dept of Cardiology ~ Brussels ~ Belgium

A83 QUANTIFICATION AND VISUALIZATION OF PULMONARY VASCULAR RESPONSE TO NITRIC OXIDE USING COMPUTED TOMOGRAPHYFarbod Rahaghi*[5], Tilo Winkler[2], Puja Kohli[3], Berta Marti Fuster[4], Ramya Radhakrishnan[5], Tyler Blackwater[1], James Ross[4], Richard Channick[3], R Scott Harris[3], Raúl San José Estépar[4], George Washko[5]

[1]Harvard Medical School, Brigham and Women’s Hospital ~ Boston ~ United States of America, [2]Harvard Medical School, Massachusetts General Hospital, Anesthesia, Critical Care and Pain Medicine ~ Boston ~ United States of America, [3]Harvard Medical School, Massachusetts General Hospital, Pulmonary and Critical Care ~ Boston ~ United States of America, [4]Harvard Medical School, Brigham and Women’s Hospital, Department of Radiology ~ Boston ~ United States of America, [5]Harvard Medical School, Brigham and Women’s Hospital, Division of Pulmonary and Critical Care ~ Boston ~ United States of America

A84 ABNORMAL RESPONSE TO EXERCISE IN SYSTEMIC SCLEROSIS PATIENTS WITH NORMAL PULMONARY PRESSURES AT REST: A CASE-CONTROLLED STUDYAsma Rimouche*[1], Sergio Caravita[1], Laurence Dewachter[2], Antoine Bondue[1], Jean Luc Vachiery[1]

[1]Erasme-ULB ~ Brussels ~ Belgium, [2]ULB ~ Brussels ~ Belgium



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Tuesday, February 27, 2018PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATIONA85 ADAMTS8 PROMOTES THE DEVELOPMENT OF PULMONARY

ARTERIAL HYPERTENSION AND RIGHT VENTRICULAR FAILURE -A POSSIBLE NOVEL THERAPEUTIC TARGET-Kimio Satoh*[1], Junichi Omura[1], Nobuhiro Kikuchi[1], Taijyu Satoh[1], Ryo Kurosawa[1], Masamichi Nogi[1], Shinichiro Sunamura[1], Tomohiro Ohtsuki[1], Elias Al-Mamun[1], Mohammad Abdul Hai Siddique[1], Nobuhiro Yaoita[1], Satoshi Miyata[1], Yasushi Hoshikawa[2], Yoshinori Okada[2], Hiroaki Shimokawa[1]

[1]Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan, [2]Department of Thoracic Surgery, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan

A86 RIGHT VENTRICULAR CHARACTERISTICS IN EISENMENGER SYNDROME – ECG AND ECHO CORRELATIONSTatiana Valkovicova*[1], Monika Kaldararova[1], Adriana Reptova[1], Marcela Bohacekova[1], Ljuba Bacharova[2], Robert Hatala[1], Iveta Simkova[1]

[1]Department of Cardiology and Angiology, Slovak Medical University and National Institute of Cardiovascular Diseases ~ Bratislava ~ Slovakia, [2]International Laser Center ~ Bratislava ~ Slovakia

A87 TRANSITION FROM POST- TO COMBINED PRE/POST-CAPILLARY PULMONARY HYPERTENSION: KEY ROLE OF ENDOTHELINRichard WB van Duin*[1], Kelly Stam[1], Zongye Cai[1], Dirk Jan Duncker[1], Irwin Karl Reiss[2], Daphne Merkus[1]

[1]Erasmus MC ~ Rotterdam ~ Netherlands, [2]Sophia Children’s hospital ~ Rotterdam ~ Netherlands

PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPSA88 PULMONARY HYPERTENSION IN TAKAYASU ARTERITIS

Ali Akdogan*[1], Esra Firat[2], Yusuf Ziya Sener[3], Berkan Armagan[1], Metin Oksul[3], Serkan Asil[3], Vedat Hekimsoy[3], Abdulsamet Erden[1], Alper Sari[1]

[1]Hacettepe University Faculty of Medicine, Department of Rheumatology ~ Ankara ~ Turkey, [2]Hacettepe University Faculty of Medicine, Department of Internal Medicine ~ Ankara ~ Turkey, [3]Hacettepe University Faculty of Medicine, Department of Cardiology ~ Ankara ~ Turkey

A89 A COMPARISON OF NT-PROBNP LEVELS IN PATIENTS WITH SSC-ASSOCIATED PAH AND PATIENTS WITH SSC–RELATED PH ASSOCIATED WITH LUNG DISEASE Sahachat Aueyingsak*, Wilaiwan Khrisanapant, Upa Kukongviriyapun, Orapin Pasurivong, Burabha PussadhammaFaculty of Medicine, Khon Kaen University ~ Khon Kaen ~ Thailand

A90 RESULTS OF MEDIUM SEVEN YEARS’FOLLOW-UP IN SYSTEMIC SCLEROSIS PATIENTS WITH EXERCISE INDUCED PULMONARY HYPERTENSION MEASURED DURING RIGHT HEART CATHETERIZATIONLuciana D’Angelo*, Andrea Garascia, Eleonora Bruschi, Francesco Musca, Oscar Massimiliano Epis, Antonella Moreo, Maria FrigerioASST Grande Ospedale Metropolitano Niguarda ~ Milan ~ Italy

A91 JOGJAKARTA CONGENITAL HEART DISEASE AND PULMONARY HYPERTENSION (COHARD-PH) STUDY: RESULTS FROM A SINGLE-CENTER NATIONAL REFERRAL HOSPITAL REGISTRY IN INDONESIALucia Kris Dinarti*, Dyah Wulan Anggrahini, Anggoro Budi HartopoDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Gadjah Mada - Dr Sardjito Hospital ~ Yogyakarta ~ Indonesia



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POSTER SESSIONS

Tuesday, February 27, 2018PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPSA92 THE MORTALITY OF PREGNANT PATIENTS WITH UNCORRECTED

ATRIAL SEPTAL DEFECT IS INFLUENCED BY SEVERE PULMONARY HYPERTENSION – A SUBSTUDY OF JOGJAKARTA COHARD-PH REGISTRY Anggoro Budi Hartopo*, Dyah Wulan Anggrahini, Lucia Kris DinartiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Gadjah Mada ~ Yogyakarta ~ Indonesia

A93 PULMONARY HYPERTENSION IN ASIA: INSIGHTS FROM AN ASIAN TERTIARY REFERRAL CENTRETeng Yik Hoo*[1], Benjamin Chew[1], Jonathan Yap[1], Wen Ruan[1], Jeremy Teoh[1], Maggie Wong[1], Sewa Du Wen[2], Ghee Chee Phua[2], Andrea Low[3], Ju Le Tan[1], Soo Teik Lim[1]

[1]Department of Cardiology, National Heart Centre Singapore ~ Singapore ~ Singapore, [2]Department of Respiratory Medicine, Singapore General Hospital ~ Singapore ~ Singapore, [3]Department of Rheumatology, Singapore General Hospital ~ Singapore ~ Singapore

A94 THE DISPROPORTIONAL INCREASE OF PULMONARY PRESSURE IS RELATED TO THE CLINICAL OUTCOMES IN PATIENTS WITH CHRONIC HEART FAILUREWei-Ming Huang*, Shih-Hsien SungTaipei Veterans General Hospital ~ Taipei ~ Taiwan

A95 THE DETERMINANTS OF “OUT OF PROPORTION” PULMONARY HYPERTENSION IN PATIENTS WITH MILD CHRONIC OBSTRUCTION PULMONARY DISEASEWei-Ming Huang*, Shih-Hsien SungDepartment of Medicine, Taipei Veterans General Hospital ~ Taipei ~ Taiwan

A96 IMPACT OF BLOOD VISCOSITY ON PULMONARY VASCULAR RESISTANCE IN PATIENTS ASSESSED FOR PULMONARY HYPERTENSION AT A LARGE TERTIARY CENTREAleksander Kempny*, Konstantinos Dimopoulos, Colm Mccabe, Rafael Alonso-Gonzalez, Laura Price, Michael Gatzoulis, Stephen J WortRoyal Brompton Hospital ~ London ~ United Kingdom

A97 GENDER ASPECTS AMONG PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION IN THE MODERN TREATMENT ERABarbro Kjellström*[1], Clara Hjalmarsson[2], David Kylhammar[3], Sven-Erik Bartfay[2], Göran Rådegran[4], Magnus Nisell[5]

[1]Karolinska Institute ~ Stockholm ~ Sweden, [2]Sahlgrenska Universitetssjukhuset ~ Göteborg ~ Sweden, [3]Linköping Universitetssjukhus ~ Linköping ~ Sweden, [4]Skåne Universitetssjukhus ~ Lund ~ Sweden, [5]Karolinska Universityhospital ~ Stockholm ~ Sweden

A98 CHARACTERISTICS OF PULMONARY ARTERIAL HYPERTENSION IN PATIENTS WITH SYSTEMIC SCLEROSIS AND ANTICENTRIOLE AUTOANTIBODIESKana Kubota*Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo ~ Bunkyo-ku, Tokyo ~ Japan

A99 PH EXPERIENCE IN A TERTIARY CENTERMehmet Serdar Kucukoglu*, Mert Palabiyik, Ozge Cetinarslan, Rengin DemirIstanbul University Institute of Cardiology ~ Istanbul ~ Turkey

A100 PULMONARY HYPERTENSION IN GREECE: PRELIMINARY DATA FROM A NATIONAL REGISTRY Athanasios Manginas*[9], Maria Toumpourleka[1], George Giannakoulas[1], Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], Iraklis Tsangaris[3], Eleni Stagaki[3], Stylianos Orfanos[3], Georgia Pitsiou[4], Evangelia Panagiotidou[4], Ioanna Mitrouska[5], Ekaterini Avgeropoulou[6], Katerina Naka[7], Stavros Konstandinides[8], Anastasia Anthi[3]

[1]Aristotle University of Thessaloniki ~ Thessaloniki ~ Greece, [2]Department of Cardiology, Onassis Cardiac Surgery Center ~ Athens ~ Greece, [3]Attikon University Hospital ~ Athens ~ Greece, [4]Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, [5]Pulmonary Department, University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Greece, [6]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [7]Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Greece, [8]Cardiology Department, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [9]Department of Cardiology, Mediterraneo Hospital ~ Athens ~ Greece



27

POSTER SESSIONS

Tuesday, February 27, 2018PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPSA101 PREVALENCE AND CORRELATES OF OBESITY IN PRECAPILLARY

PULMONARY HYPERTENSIONAthanasios Manginas*[9], Maria Toumpourleka[1], George Giannakoulas[1], Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], Iraklis Tsangaris[3], Eleni Stagaki[3], Stylianos Orfanos[3], Stylianos Orfanos[3], Georgia Pitsiou[4], Evangelia Panagiotidou[4], Ioanna Mitrouska[5], Ekaterini Avgeropoulou[6], Katerina Naka[7], Stavros Konstandinides[8], Anastasia Anthi[3]

[1]Aristotle University of Thessaloniki ~ Thessaloniki ~ Greece, [2]Department of Cardiology, Onassis Cardiac Surgery Center ~ Athens ~ Greece, [3]Attikon University Hospital ~ Athens ~ Greece, [4]Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, [5]Pulmonary Department, University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Greece, [6]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [7]Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Greece, [8]Cardiology Department, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [9]Department of Cardiology, Mediterraneo Hospital ~ Athens ~ Greece

A102 ECHOCARDIOGRAPHIC ASSESSMENT OF RIGHT VENTRICULAR COUPLING TO PULMONARY CIRCULATION IS ASSOCIATED WITH HEMODYNAMIC DISEASE SEVERITY IN PRECAPILLARY PULMONARY HYPERTENSIONAthanasios Manginas*[10], Maria Toumpourleka[1], George Giannakoulas[1], Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], Spyridon Rammos[2], Spyridon Rammos[2], Iraklis Tsangaris[3], Eleni Stagaki[4], Stylianos Orfanos[4], Georgia Pitsiou[5], Evangelia Panagiotidou[5], Evangelia Panagiotidou[5], Ioanna Mitrouska[6], Ekaterini Avgeropoulou[7], Katerina Naka[8], Stavros Konstandinides[9], Anastasia Anthi[4]

[1]Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki ~ Thessaloniki ~ Greece, [2]Department of Cardiology, Onassis Cardiac Surgery Center ~ Athens ~ Greece, [3]2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens ~ Athens ~ Greece, [4]Pulmonary Hypertension Clinic, Department of Critical Care, Attikon Hospital, National and Kapodistirian University of Athens ~ Athens ~ Greece, [5]Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, [6]

Pulmonary Department, University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Greece, [7]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [8]Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Greece, [9]Cardiology Department, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [10]

Department of Cardiology, Mediterraneo Hospital ~ Athens ~ Greece

A103 THE BLOOD COUNT LEVELS, THE MEAN PULMONARY ARTERY PRESSURE AND SIX MINUTE WALK TEST AMONG ADULT FILIPINOS WITH PULMONARY HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASES: RESULTS FROM THE PHILIPPINE HEART CENTER – CENTER FOR PULMONARY VASCULAR DISORMaria Paz Mateo*Philippine Heart Center ~ Quezon City ~ Philippines

A104 COMPARISON OF CARDIAC OUTPUT DETERMINATION BY THE INDIRECT FICK AND THE THERMODILUTION METHOD IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONSophia Anastasia Mouratoglou*, Ioannis Doundoulakis, Feloukidis Cristos, Bazmpani Maria Anna, Arvanitaki Alexandra, Toumpourleka Maria, Grosomanidis Vasileios, Hadjimiltiades Stavros, Karvounis Haralambos, Giannakoulas GeorgeFirst Department of Cardiology, AHEPA University Hospital of Thessaloniki ~ Thessaloniki ~ Greece

A105 PULMONARY ARTERIAL HYPERTENSION IN IGG4-RELATED DISEASE: ALL ABOUT THE EPOPROSTENOL?Nicole Ruopp*, Harrison FarberBoston University ~ Boston ~ United States of America

A106 PULMONARY ARTERY DILATATION PROGRESS IN PATIENTS WITH PULMONARY HYPERTENSION COEXISTING PULMONARY ARTERY ANEURYSM - POSSIBLE INVOLVEMENT OF PROSTAGLANDIN E RECEPTOR TYPE 4 OVEREXPRESSION-Akagi Satoshi*[1], Nakamura Kazufumi[1], Yokoyama Utako[2], Kasahara Shingo[3], Sarashina Toshihiro[1], Ejiri Kentaro[1], Ito Hiroshi[1]

[1]Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ~ Okayama ~ Japan, [2]Department of Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine ~ Yokohama ~ Japan, [3]Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ~ Okayama ~ Japan



28

POSTER SESSIONS

Tuesday, February 27, 2018PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPSA107 DIFFERENTIAL INCREASE IN CIRCULATING PAN VEGF-A AND

VEGF-A165B LEVELS AMONG SUBTYPE OF PULMONARY HYPERTENSIONShigetake Shimokata*[1], Kikuchi Ryosuke[2], Adachi Shiro[3], Okumura Naoki Okumura[3], Tajima Fumitaka[1], Kamimura Yoshihiro[1], Nakano Yoshihisa[1], Kondo Takahisa[3], Murohara Toyoaki[1]

[1]Department of Cardiology, Nagoya University Graduate School of Medicine ~ Nagoya ~ Japan, [2]Department of Medical Technique, Nagoya University Hospital ~ Nagoya ~ Japan, [3]Department of Advandced in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine ~ Nagoya ~ Japan

A108 SEVERE PULMONARY ARTERIAL HYPERTENSION IN PATIENTS TREATED BY CHINESE HERB NATURE INDIGO: QING-DAIYuichi Tamura*[1], Asuka Furukawa[1], Ly Tu[2], Christophe Guignabert[2], Marc Humbert[2], Noriaki Emoto[3], Hiroshi Watanabe[4], Koichiro Tatsumi[5]

[1]IUHW Mita Hospital ~ Tokyo ~ Japan, [2]South Paris University ~ Paris ~ France, [3]Kobe University ~ Kobe ~ Japan, [4]Hamamatsu University School of Medicine ~ Hamamatsu ~ Japan, [5]Chiba University ~ Chiba ~ Japan

A109 CLINICAL CHARACTERISTICS AND SURVIVAL OF ASIAN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONJonathan Yap*[2], Teng Yik Hoo[2], Jeremy Teoh[2], Benjamin Chew[2], Duu Wen Sewa[1], Ghee Chee Phua[1], Andrea Low[3], Choong Hee Lim[2], Ju Le Tan[2], Maggie Wong[2], Wen Ruan[2]

[1]Department of Respiratory Medicine, Singapore General Hospital ~ Singapore ~ Singapore, [2]Department of Cardiology, National Heart Centre Singapore ~ Singapore ~ Singapore, [3]Department of Rheumatology, Singapore General Hospital ~ Singapore ~ Singapore

A110 THE STRUCTURAL-FUNCTIONAL STATE OF THE SYSTEMIC CIRCULATION ARTERIES IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONIryna Zhyvylo*, Yurii Sirenko, Ganna RadchenkoSI «National Scientific Centre «M. D. Strazhesko Institute of Cardiology» of NAMS of Ukraine» ~ Kyiv ~ Ukraine

DIAGNOSIS OF PULMONARY HYPERTENSIONA111 DEATH OR RESOLUTION: THE NATURAL HISTORY OF

PULMONARY HYPERTENSION IN BRONCHOPULMONARY DYSPLASIAGabriel Altit*, Shazia Bhombal, Theresa Tacy, Jeffrey FeinsteinStanford University ~ Palo Alto ~ United States of America

A112 RECEPTOR TYROSINE KINASES AND RELATED LIGANDS PROVIDE NEW PLASMA BIOMARKERS IN PULMONARY ARTERIAL HYPERTENSIONHabib Bouzina*~ Lunds University - Lund - Sweden

A113 NONSYNDROMIC PERIPHERAL PULMONARY ARTERY STENOSIS IS ASSOCIATED WITH HOMOZYGOSITY OF RNF213 P.ARG4810LYS REGARDLESS OF CO-OCCURRENCE OF MOYAMOYA DISEASESung-A Chang*, Ju Sun Song, Taek Kyu Park, Jung Hoon Yang, Woo Chan Kwon, So Ree Kim, Sung Mok Kim, Jihoon Cha, Shin Yi Jang, Young Seok Cho, Tae Jung Kim, Oh Young Bang, Jin Young Song, Chang Seok Ki, Duk-Kyung KimSamsung Medical Center, Sungkyunkwan University School of Medicine ~ Seoul ~ Korea, Republic of

A114 CLINICAL PROFILING AND PREDICTING CLINICAL DETERIORATION IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTS IN A PULMONARY HYPERTENSION REFERENCE CENTER IN CAMPINAS-BRAZILMônica Corso Pereira*[1], Plínio José Whitaker Wolf[2]

[1]Faculty of Medical Sciences of the State University of Campinas (Unicamp) ~ Campinas ~ Brazil, [2]Student of the Faculty of Medicine of Pontifical Catholic University of Campinas (Puccamp) ~ Campinas ~ Brazil



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POSTER SESSIONS

Tuesday, February 27, 2018DIAGNOSIS OF PULMONARY HYPERTENSIONA115 INCIDENCE OF PULMONARY HYPERTENSION AND

DETERMINING FACTORS IN PATIENTS WITH SYSTEMIC SCLEROSIS AFTER NEGATIVE RIGHT HEART CATHETERISATIONSatenik Harutyunova*[2], Gerry Coghlan[1], Matthias Wolf[2], Oliver Distler[3], Christopher P Denton[4], Martin Doelberg[5], Alberto Marra[2], Nicola Benjamin[2], Christine Fischer[6], Ekkehard Grünig[2]

[1]Cardiology Department, Royal Free Hospital, London ~ London ~ United Kingdom, [2]

Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [3]Department of Rheumatology, Faculty of Medicine, University of Zurich ~ Zürich ~ Switzerland, [4]Centre of Rheumatology, Royal Free Hospital, London ~ London ~ United Kingdom, [5]Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, CH-4123 Allschwil, Switzerland ~ Allschwil ~ Switzerland, [6]Institute of biostatistics University clinic Heidelberg ~ Heidelberg ~ Germany

A116 PULMONARY HYPERTENSION IN ASIA: ESTIMATED PREVALENCE AND PROGNOSIS FROM THE ECHOCARDIOGRAPHY COHORTChih-Hsin Hsu*[2], Wei-Ting Chang[1], Hsiang-Yuan Chang[3], Wei-Shin Liu[4], Wei-Da Lu[2]

[1]Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Yungkang Dist ~ Tainan ~ Taiwan, [2]Department of Internal Medicine,National Cheng Kung University ~ Tainan ~ Taiwan, [3]National Cheng Kung University Hospital Dou-Liou Branch ~ Dou-Liou ~ Taiwan, [4]Tzu-Chi General Hospital ~ Hualien ~ Taiwan

A117 PREVALENCE OF PULMONARY HYPERTENSION IN PATIENTS WITH SARCOIDOSIS: A SINGLE CENTER EXPERIENCEDeniz Kaptan Ozen*[1], Bulent Mutlu[1], Alper Kepez[1], Derya Kocakaya[2], Berrin Ceyhan[2], Batur Gonenc Kanar[1], Okan Erdogan[1], Halil Atas[1]

[1]Marmara University Medical Faculty Cardiology Department ~ ISTANBUL ~ Turkey, [2]

Marmara University Medical Faculty Pneumology Department ~ ISTANBUL ~ Turkey

A118 EFFICIENT DETECTION OF PULMONARY ARTERIAL HYPERTENSION USING SERUM HAPTOGLOBIN LEVEL AND CARDIAC MRI IN PATIENTS WITH CONNECTIVE TISSUE DISEASESMasaru Kato*[1], Hiroyuki Nakamura[1], Eri Sugawara[1], Yuichiro Fujieda[1], Kenji Oku[1], Toshiyuki Bohgaki[1], Shinsuke Yasuda[1], Hiroshi Ohira[2], Ichizo Tsujino[2], Masaharu Nishimura[2], Tatsuya Atsumi[1]

[1]Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University ~ Sapporo ~ Japan, [2]First Department of Medicine, Hokkaido University Hospital ~ Sapporo ~ Japan

A119 NAILFOLD VIDEOCAPILLAROSCOPY PARAMETERS AS A PREDICTORS OF PULMONARY ARTERIAL HYPERTENSION DEVELOPMENT IN PATIENTS WITH SYSTEMIC SCLEROSISNataliya Klyaus*, Maria Simakova, Kirill Malikov, Alexey Maslyanskiy, Olga MoiseevaFederal State Budgetary Institution “V.A. Almazov National Medical Research Center” of the Ministry of Health of the Russian Federation ~ Saint-Petersburg ~ Russian Federation

A120 ACCURACY AND PRECISION OF MEAN PULMONARY PRESSURE ASSESSED BY ECHOCARDIOGRAPHY AMONG PATIENTS WITH PULMONARY HYPERTENSIONAdrian Lescano*, Juan Farina, Hector Gomez Santa Maria, Augusto Lavalle Cobo, Guadalupe Romero, Nicolas Gonzalez, Miguel Gonzalez, Victor Daru, Hugo GrancelliFinochietto Clinic ~ Buenos Aires ~ Argentina

A121 RAISING PAH AWARENESS IN SERBIASenka Milutinov*, Ilija Andrijevic, Jovan Matijasevic, Ana AndrijevicInstitute for Pulmonary Diseases of Vojvodina ~ Sremska Kamenica ~ Serbia

A122 RIGHT HEART CATHETERIZATION FOR THE ASSESSMENT OF PULMONARY HYPERTENSION IN PATIENTS WITH INTERSTITIAL LUNG DISEASENesrin Mogulkoc*[1], Hakan Kultursay[2], Bahri Akdeniz[3]

[1]Ege University Hospital Pulmonology Department ~ Izmir ~ Turkey, [2]Ege University Hospital, Cardiology Department ~ Izmir ~ Turkey, [3]Dokuz Eylul University Hospital, Cardiology Department ~ Izmir ~ Turkey

A123 EVALUATION OF CARDIAC FUNCTIONAL ALTERATIONS AND NATRIURETIC PEPTIDE LEVELS IN PATIENTS WITH SYSTEMIC SARCOIDOSISBulent Mutlu*[1], Deniz Kaptan Ozen[1], Alper Kepez[1], Derya Kocakaya[2], Berrin Ceyhan[2], Okan Erdogan[1], Batur Gonenc Kanar[1], Halil Atas[1]

[1]Marmara University Medical Faculty Cardiology Department ~ ISTANBUL ~ Turkey, [2]

Marmara University Medical Faculty Pneumology Department ~ ISTANBUL ~ Turkey



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POSTER SESSIONS

Tuesday, February 27, 2018DIAGNOSIS OF PULMONARY HYPERTENSIONA124 THE CONTRIBUTION OF ENDOTHELIAL CELLS TO THE

VOLATOLOMIC SIGNATURE OF PAHMorad Nakhleh*[1], Salam Khatib[2], Ly Tu[1], Maria Vinhas[1], Barbara Girerd[1], Frederic Perros[1], David Montani[1], Raneen Jeries[2], Peter Dorfmuller[1], Elie Fadel[1], Christophe Guignabert[1], Marc Humbert[1], Hossam Haick[2], Sylvia Cohen-Kaminsky[1]

[1]1Univ Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France. 2 AP-HP, DHU TORINO, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France. 3 Inserm UMR_S 999, LabExLERMIT, Hôpital Marie Lannelongue ~ Le Plessis Ro, [2]Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion–Israel Institute of Technology ~ Haifa ~ Israel

A125 CONGENITAL HEART DISEASES: A RARE REASON FOR PULMONARY HYPTERTENSION IN ADULT PATIENTSGulfer Okumus*[1], Celik Sumer[1], Zuleyha Bingol[1], Gokcen Orhan[2], Murat Inanc[3], Ahmet Kaya Bilge[4]

[1]Istanbul University Medical Faculty Department of Pulmonary Diseases ~ Istanbul ~ Turkey, [2]Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Department of Cardiovasculary Surgery ~ Istanbul ~ Turkey, [3]

Istanbul University Medical Faculty Department of Rheumatology ~ Istanbul ~ Turkey, [4]

Istanbul University Medical Faculty Department of Cardiology ~ Istanbul ~ Turkey

A126 TUMOR MARKERS ARE ALTERED IN PLASMA FROM PULMONARY ARTERIAL HYPERTENSION PATIENTSGöran Rådegran*[1], Habib Bouzina[2]

[1]Lund University ~ Lund ~ Sweden, [2]~ Sweden

A127 PULMONARY HYPERTENSION (PH) DUE TO LEFT HEART DISEASE: A PREDICTIVE MODEL USING THE NATIONAL ECHO DATABASE OF AUSTRALIA (NEDA)Geoff Strange*[1], David Playford[1], Jim Codde[1], David Celermajer[2], Gregory Scalia[3], Kevin Chung[1]

[1]The University of Notre Dame ~ Fremantle ~ Australia, [2]The University of Sydney ~ Sydney ~ Australia, [3]The University of Queensland ~ Brisbane ~ Australia

A128 CT FUNCTIONAL PARAMETERS FOCUSING ON RVOT FOR PHYi-Shan Tsai*[2], Hsu Chih-Hsin[1]

[1]Department of Cardiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University ~ Tainan ~ Taiwan, [2]Department of Diagnostic Radiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University ~ Tainan ~ Taiwan



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POSTER SESSIONS

Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB10 EFFICACY OF ORAL IRON SUBSTITUTION IN NONANEMIC-IRON

DEFICIENT PAH PATIENTS Bahri Akdeniz*, Ebru Özpelit, Dilek Sezgin, Bihter Sentürk, Can Sevinç, Resit Yigit Yilancioglu, Nezihi BarisNo ~ Izmir ~ Turkey

B11 HOW EFFICACIOUS IS THE GUIDELINE BASED RISK STRATIFICATION IN WHOLE PAH POPULATION IN ROUTINE PRACTICE?Bahri Akdeniz*, Ebru Özpelit, Dilek Sezgin, Can Sevinç, Nezihi Baris, Bihter SentürkNo ~ Izmir ~ Turkey

B12 RELATIONSHIP BETWEEN BALANCE AND EXERCISE CAPACITY IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONBahri Akdeniz*, Buse Ozcan Kahraman, Sema Savci, Ismail Ozsoy, Serap Acar, Ebru Ozpelit, Can SevincDokuz Eylul University ~ Izmir ~ Turkey

B13 ROLE OF CARDIAC MAGNETIC RESONANCE IN STRATIFYING THE PROGNOSIS OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONAlessandra Albini*, Fabio Dardi, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Enrico Monti, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

B14 TRANSITION FROM SUBCUTANEOUS TREPROSTINIL TO INTRAVENOUS THERMOSTABLE EPOPROSTENOL IN PATIENTS WITH SEVERE PULMONARY ARTERIAL HYPERTENSION Anastasia Anthi*[1], Konstantina Ntai[1], Dimitrios Konstantonis[1], Frantzeska Frantzeskaki[1], Eleni Stagaki[2], Cornelia Mitrakou[1], Athanasios Pappas[2], Michalis Rizos[1], Olympia Apostolopoulou[1], Apostolos Armaganidis[1], Stylianos Orfanos[1]

[1]Pulmonary Hypertension Clinic and 2nd Department of Critical Care, University of Athens, “Attikon” Hospital ~ Athens ~ Greece, [2]Pulmonary Hypertension Clinic, University of Athens, “Attikon” Hospital ~ Athens ~ Greece

B15 INITIAL TREATMENT STRATEGY AND LONG-TERM SURVIVAL IN PULMONARY ARTERIAL HYPERTENSION (PAH)Athénaïs Boucly*[1], Jason Weatherald[2], Laurent Savale[1], David Montani[1], Xavier JaÏs[1], Mitja Jevnikar[1], Gérald Simonneau[1], Marc Humbert[1], Olivier Sitbon[1]

[1]Université Paris-Sud, APHP, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]

Department of Medicine, Division of Respirology, University of Calgary ~ Calgary, AB ~ Canada

B16 LONG-TERM OUTCOMES AND PREDICTORS OF SURVIVAL IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION WITHOUT ACCESS TO PARENTERAL PROSTANOID THERAPYElena Dimitrova*[1], Arman Postadzhiyan[2], Bozhidar Finkov[2], Blagorodna Karatancheva[2], Emilia Naseva[3], Vasil Velchev[2]

[1]National Heart Hospital ~ Sofia ~ Bulgaria, [2]University Hospital “Saint Anna” ~ Sofia ~ Bulgaria, [3]Medical University - Sofia ~ Sofia ~ Bulgaria

B17 IMPROVEMENT OF PULMONARY DIFFUSION CAPACITY AFTER INTRAVENOUS IRON SUBSTITUTION IN PATIENTS WITH IRON DEFICIENCY AND PULMONARY HYPERTENSIONDaniel Dumitrescu*, Tilmann Kramer, Henrik Hagmanns, Felix Gerhardt, Thomas Viethen, Stephan Baldus, Stephan RosenkranzHerzzentrum der Universitaet zu Koeln ~ Cologne ~ Germany

B18 CORRELATES OF WHO FUNCTIONAL CLASS IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASE. RESULTS FROM CHALLENGE REGISTRY.Christos Feloukidis*[1], George Giannakoulas[1], Konstantinos Vasiliadis[2], Alexandra Frogoudaki[3], Christos Ntellos[4], Afroditi Tzifa[10], Styliani Brili[5], Athanasios Manginas[6], Despina Ntiloudi[1], Marios Kolios[7], Antonios Pitsis[8], Haralambos Karvounis[1], Konstantinos Tsioufis[5], Spyridon Rammos[9]

[1]Cardiology Department, AHEPA University Hospital ~ Thessaloniki ~ Greece, [2]

Cardiology Department, G. Papanikolaou Hospital ~ Thessaloniki ~ Greece, [3]

Cardiology Department, Attikon University Hospital ~ Athens ~ Greece, [4]Cardiology Department, Tzaneio General Hospital of Piraeus ~ Athens ~ Greece, [5]Cardiology Department, Hippokrateion University Hospital ~ Athens ~ Greece, [6]Cardiology Department, Mediterraneo Hospital ~ Athens ~ Greece, [7]Cardiology Department, University Hospital of Ioannina ~ Ioannina ~ Greece, [8]Department of Cardiothoracic Surgery, Saint Luke’s Clinic ~ Thessaloniki ~ Greece, [9]Department of Paediatric Cardiology and ACHD, Onassis Cardiac Surgery Centre ~ Athens ~ Greece, [10]

Department of Congenital Heart Disease, Mitera Children’s Hospital ~ Athens ~ Greece



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POSTER SESSIONS

Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB19 EXERCISE CMR TO EVALUATE RV FUNCTION AND

HEMODYNAMICS IN PAH: PILOT STUDYVeronica Franco*, Eks Wye Pollock, Subha RamanThe Ohio State University ~ Columbus, Ohio ~ United States of America

B20 INVESTIGATION OF HEPATIC FIBROSIS AS A NOVEL PROGNOSTIC FACTOR IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONAsuka Furukawa*, Yuichi TamuraInternational University of Health and Welfare Mita Hospital ~ Tokyo ~ Japan

B21 AUDIT OF DISEASE TARGETED THERAPIES IN ADULT PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION Wendy Gin-Sing*[1], Simon Gibbs[1], Luke Howard[1], Rachel Davies[1], George Villa[1], Margaret Lau-Walker[2], Geraldine Lee[2]

[1]Hammersmith Hospital ~ London ~ United Kingdom, [2]King’s College ~ London ~ United Kingdom

B22 SAFETY OF SWITCHING TO RIOCIGUAT FOR THE TREATMENT OF PULMONARY HYPERTENSION: DATA FROM THE EXPERT REGISTRYEkkehard Grünig*[1], Henning Gall[2], Hossein-Ardeschir Ghofrani[2], Marc Humbert[3], Gérald Simonneau[3], Hans Klose[4], Michael Halank[5], David Langleben[6], Repke Snijder[17], Pilar Escribano[11], Lisa Mielniczuk[7], Tobias Lange[10], Jean-Luc Vachiéry[8], Hubert Wirtz[9], Douglas Helmersen[12], Iraklis Tsangaris[14], Joan Albert Barberá[15], Joanna Pepke-Zaba[13], Anco Boonstra[16], Stephan Rosenkranz[25], Sylvia Ulrich[26], Regina Mascherbauer[18], Marion Delcroix[19], Pavel Jansa[27], Miguel Angel Gómez Sánchez[20], Jens Klotsche[21], Christian Meier[22], David Pittrow[23], Marius M Hoeper[24]

[1]Thoraxclinic at Heidelberg University Hospital ~ Heidelberg ~ Germany, [2]University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL) ~ Giessen ~ Germany, [3]Université Paris-Sud, Le Kremlin-Bicêtre, Service de Pneumologie, Centre de Référence de l’Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [4]Section Pneumology, University Medical Center Hamburg-Eppendorf ~ Hamburg ~ Germany, [5]Medical Clinic I, Department of Pneumology, University Hospital Carl Gustav Carus ~ Dresden ~ Germany, [6]Jewish General Hospital, McGill University ~ Montreal, Quebec ~ Canada, [7]

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute ~ Ottawa ~ Canada, [8]Département de Cardiologie, Cliniques Universitaires de Bruxelles, Hôpital Erasme ~ Brussels ~ Belgium, [9]Department of Respiratory Medicine, University of Leipzig ~ Leipzig ~ Germany, [10]Department of Internal Medicine II, Division of Pneumology, University Medical Center ~ Regensburg ~ Germany, [11]Department of Cardiology, Hospital 12 de Octubre ~ Madrid ~ Spain, [12]Alberta Health Services, University of Calgary ~ Calgary, Alberta, ~ Canada, [13]Pulmonary Vascular Disease Unit, Papworth Hospital ~ Cambridge ~ United Kingdom, [14]Second Department of Critical Care, University Hospital Attikon ~ Athens ~ Greece, [15]Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer and University of Barcelona ~ Barcelona ~ Spain, [16]VU Medisch Centrum ~ Amsterdam ~ Netherlands, [17]Department of Pulmonology, St Antonius Ziekenhuis ~ Nieuwegein ~ Netherlands, [18]Servicestelle für klinische Studien, Krankenhaus der Elisabethinen Linz GmbH ~ Linz ~ Austria, [19]

Department of Pulmonology, Katholieke Universiteit ~ Leuven ~ Belgium, [20]Hospital General Nuestra Señora del Prado, Talavera de la Reina ~ CIBERES ~ Spain, [21]German Rheumatism Research Center Berlin, Leibniz Institute ~ Berlin ~ Germany, [22]Bayer AG, Global Development, Global Medical Affairs ~ Berlin ~ Germany, [23]Institute for Clinical Pharmacology, Medical Faculty, Technical University ~ Dresden ~ Germany, [24]Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School ~ Hannover ~ Germany, [25]Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center ~ Cologne ~ Germany, [26]Klinik für Pneumologie, UniversitätsSpital Zürich ~ Zurich ~ Switzerland, [27]2nd Department of Medicine – Department of Cardiovascular Medicine, Charles University in Prague ~ Prague ~ Czech Republic



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Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB23 RISK STRATIFICATIONS AND DEATHS IN ADULT UNCORRECTED

ATRIAL SEPTAL DEFECT WITH PULMONARY HYPERTENSION: AN INDONESIAN EXPERIENCEAnggoro Budi Hartopo*, Dyah Wulan Anggrahini, Lucia Kris DinartiDepartment of Cardiology and Vascular Medicine Universitas Gadjah Mada/Sardjito General Hospital ~ Yogyakarta ~ Indonesia

B24 INITIAL COMBINATION THERAPY WITH RIOCIGUAT AND AMBRISENTAN IN PULMONARY ARTERIAL HYPERTENSION: A PROSPECTIVE OPEN-LABEL STUDYNaushad Hirani*, Jason Weatherald, Doug Helmersen, Mitesh Thakrar, Rhea Varughese, Carmen Lydell, Nowell FineUniversity of Calgary ~ Calgary ~ Canada

B25 IMPACT OF AGE AND COMORBIDITY ON OUTCOME IN IDIOPATHIC PULMONARY HYPERTENSION: DATA FROM THE SWEDISH PULMONARY ARTERIAL HYPERTENSION REGISTRYClara Hjalmarsson*[2], Göran Rådegran[1], David Kylhammar[3], Bengt Rundqvist[2], Jonas Multing[2], Magnus Nisell[4], Barbro Kjellström[4]

[1]Department of Clinical Sciences, Cardiology, Lund University and Skåne University Hospital ~ Lund ~ Sweden, [2]Department of Cardiology, Sahlgrenska Academy, Gothenburg University, and Sahlgrenska University Hospital ~ Göteborg ~ Sweden, [3]

Department of Clinical Physiology and Department of Medicine and Health Sciences, Linköping University ~ Linköping ~ Sweden, [4]Cardiology Unit, Department of Medicine, Karolinska Institute ~ Stockholm ~ Sweden

B26 EFFICACY AND SAFETY OF EARLY SEQUENTIAL COMBINATION THERAPY WITH RIOCIGUAT AND ENDOTHELIN RECEPTOR ANTAGONISTS IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: RESULTS FROM PATENT-1 AND PATENT-2Marc Humbert*[1], Ekkehard Grünig[2], Pavel Jansa[3], Gérald Simonneau[1], Franck Rahaghi[4], Stephan Rosenkranz[5], Dennis Busse[6], Christian Meier[7], Janethe De Oliveira Pena[8], Hossein-Ardeschir Ghofrani[9]

[1]Université Paris-Sud, Le Kremlin-Bicêtre, Service de Pneumologie, Centre de Référence de l’Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]Centre for Pulmonary Hypertension, Thoraxclinic at Heidelberg University Hospital ~ Heidelberg ~ Germany, [3]Clinical Department of Cardiology and Angiology, 1st Faculty of Medicine, 2nd Medical Department, Charles University ~ Prague ~ Czech Republic, [4]Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Florida, Weston ~ Florida ~ United States of America, [5]Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center ~ Cologne ~ Germany, [6]Chrestos Concept GmbH & Co. KG ~ Essen ~ Germany, [7]Bayer AG, Global Development, Global Medical Affairs ~ Berlin ~ Germany, [8]Bayer HealthCare Pharmaceuticals Inc, Whippany ~ New Jersey ~ United States of America, [9]

University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany, member of the German Center for Lung Research (DZL) ~ Giessen ~ Germany

B27 HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND INFLAMMATORY MARKERS IN PREDICTION OF LONG-TERM RESPONSIVENESS TO CALCIUM CHANNEL BLOCKERS IN PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSIONKamil Jonas*, Marcin Waligora, Wojciech Magon, Jakub Stepniewski, Piotr Podolec, Grzegorz KopecDepartment of Cardiac and Vascular Diseases Jagiellonian University Medical College ~ Krakow ~ Poland

B28 OUTCOME OF COMPRESSION OF LEFT CORONANY ARTERY IN PATIENTS WITH SEVERE PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASESJo Won Jung*, Sang Eun Lee, Hyuk-Jae Chang, Se Yong Jung, Jae Young Choi, Yu Lim Shin, Han Ki Park, Young Hwan ParkYonsei University College of Medicine ~ Seoul ~ Korea, Republic of

B29 EARLY EXPERIENCE OF MACITENTAN FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSIONC WITH CONGENITAL HEART DISEASES IN SINGLE CENTER.Jo Won Jung*, Hyuk Jae Chang, Se Yong Jung, Jae Young ChoiYonsei University College of Medicine ~ Seoul ~ Korea, Republic of

B30 CLINICAL COURSE OF INITIAL ORAL COMBINATION THERAPY FOR THE TREATMENT OF PAH IN SYSTEMIC SCLEROSISYasushi Kawaguchi*, Yuki Ichimura, Tomoaki Higuchi, Kae TakagiInstitute of Rheumatology, Tokyo Women’s Medical University ~ Tokyo ~ Japan

B31 RAPID SEQUENTIAL COMBINATION THERAPY WITH PDE5 INHIBITORS AND ENDOTHELIN RECEPTOR ANTAGONISTS SUBSTANTIALLY IMPROVES HEMODYNAMICS AT EARLY FOLLOW-UPTilmann Kramer*, Daniel Dumitrescu, Felix Gerhardt, Phillip Nattmann, Christopher Hohmann, Stephan Baldus, Stephan RosenkranzKlinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Germany ~ Cologne ~ Germany



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Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB32 HEMODYNAMIC AND HISTOPATHOLOGIC BENEFITS OF

EARLY TREATMENT WITH MACITENTAN IN A RAT MODEL OF PULMONARY ARTERIAL HYPERTENSIONKim Kyung-Hee*[2], Kim Hyung-Kwan[1]

[1]Seoul National University Hospital ~ Seoul ~ Korea, Republic of, [2]Sejong General Hospital ~ Kyunggido ~ Korea, Republic of

B33 THE PROGNOSTIC VALUE OF DLCO AND PULMONARY BLOOD FLOW IN PATIENTS WITH PULMONARY HYPERTENSIONTobias Lange*, Nicoletta MergenthalerUniversity Medical Center Regensburg ~ Regensburg ~ Germany

B34 PULMONARY HYPERTENSION IN KOREAN PATIENTS WITH CONNECTIVE TISSUE DISEASE: RESULTS FROM EXTENDED FOLLOW-UP OF A NATION-WIDE REGISTRYShin-Seok Lee*[2], Chan Hong Jeon[1], Han Ki Park[3]

[1]Soonchunhyang University Hospital ~ Bucheon ~ Korea, Republic of, [2]Chonnam National University Bitgoeul Hospital ~ Gwangju-Gwangyeoksi ~ Korea, Republic of, [3]

Severance Hospital, Yonsei University College of Medicine ~ Seoul ~ Korea, Republic of

B35 FUNCTIONAL CAPACITY USING SUBMAXIMAL EXERCISE TEST IS RELIABLE PREDICTOR FOR AGGRAVATION OF PULMONARY HYPERTENSIONByeong-Ju Lee*, Jung Hyun ChoiPusan national university hospital ~ Busan ~ Korea, Republic of

B36 CLINICAL EFFICACY OF MACITENTAN IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: OUR EXPERIENCE IN ARGENTINAAdrian Lescano*[1], Nicolas Atamañuk[4], Vanesa Gregorietti[2], Nicolas Caruso[5], Daniela Garcia Brasca[3], Maria Lorena Coronel[6], Juan Farina[1], Sergio Perrone[2], Guillermo Bortman[5]

[1]Finochietto Clinic ~ Buenos Aires ~ Argentina, [2]Hospital El Cruce ~ Buenos Aires ~ Argentina, [3]Hospital Italiano ~ Cordoba ~ Argentina, [4]Hospital Fernandez ~ Buenos Aires ~ Argentina, [5]Sanatorio Mitre ~ Buenos Aires ~ Argentina, [6]Instituto Cabral ~ Corrientes ~ Argentina

B37 MEDICATION ADHERENCE AND RISK OF HOSPITALIZATION IN PULMONARY ARTERIAL HYPERTENSION (PAH) PATIENTS TREATED WITH ENDOTHELIN RECEPTOR ANTAGONISTS (ERAS) OR PHOSPHODIESTERASE TYPE 5 INHIBITORS (PDE5IS)Cassandra Lickert*[1], Jerrold Hill[2], Michele Cole[1], Rolin Wade[2], Yuen Tsang[1], William Drake[1]

[1]Actelion Pharmaceutical ~ South San Francisco ~ United States of America, [2]

QuintilesIMS ~ Plymouth Meeting ~ United States of America

B38 SURVIVAL OF PATIENTS WITH PULMONARY HYPERTENSION –A SINGLE CENTER EXPERIENCE IN JAPAN-Hiromi Matsubara*, Aiko OgawaNational Hospital Organization Okayama Medical Center ~ Okayama ~ Japan

B39 MORTALITY IN PULMONARY ARTERIAL HYPERTENSION TRIALS: A COMPARISON BETWEEN META-ANALYSESEnrico Monti*, Massimiliano Palazzini, Enrico Gotti, Fabio Dardi, Andrea Rinaldi, Alesandra Albini, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita Tanese, Antonio Colangelo, Mariangela Rotunno, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized, Diagnosticand Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

B40 PROGNOSTIC VALUE OF 12-LEAD ECG IN PATIENTS WITH PRECAPILLARY PULMONARY HYPERTENSIONThomas Nguyen*, Jean-Luc Vachiéry, Rubén Casado-ArroyoErasme University Hospital, Department of Cardiology ~ Brussels ~ Belgium

B41 ALLERGIC TO ONE DOES NOT MEAN TO ALLZeki Ongen*, Burcak Kilickiran Avci, Hurrem Gul OngenCerrahpasa Medical Faculty ~ Istanbul ~ Turkey

B42 CARDIOPULMONARY EXCERCISE TEST IN PULMONARY ARTERIAL HYPERTENSION PATIENTS: LONGITUDINAL CHANGES IN THE MODERN MANAGEMENT ERAEvangelia Panagiotidou*[1], Georgia Pitsiou[1], Evdokia Sourla[1], Sofia Akritidou[1], Vasileios Bagalas[1], Afroditi Boutou[2], Ioannis Stanopoulos[1]

[1]Respiratory Failure Clinic, General Hospital of Thessaloniki “G.Papanikolaou”, Aristotle University of Thessaloniki ~ THESSALONIKI ~ Greece, [2]Respiratory Clinic,General Hospital of Thessaloniki “G.Papanikolaou”, Aristotle University of Thessaloniki ~ THESSALONIKI ~ Macedonia, Former Yugoslav Republic of

B43 TREATMENT PATTERNS AND MEDICATION ADHERENCE AND PERSISTENCE AMONG PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION IN REAL-WORLD DATABASE REPRESENTING A LARGE US HEALTH PLANJanis Pruett*[2], Michael Hull[1], Eleena Koep[1], Yuen Tsang[2], William Drake[2]

[1]Optum ~ Eden Prairie ~ United States of America, [2]Actelion Pharmaceuticals, US ~ South San Francisco ~ United States of America



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Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB44 HEMODYNAMIC AND EXERCISE EFFECTS OF DIFFERENT TYPES

OF INITIAL ORAL COMBINATION THERAPY IN PULMONARY ARTERIAL HYPERTENSIONAndrea Rinaldi*, Massimiliano Palazzini, Enrico Gotti, Fabio Dardi, Alessandra Albini, Enrico Monti, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

B45 INITIAL CLINICAL RESULTS WITH MACITENTAN IN CONGENITAL HEART DISEASE PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONJoaquín Rueda-Soriano*[1], Josep Lluís Melero-Ferrer[2], Carlos Israel Chamorro-Fernández[3], Francisco Buendia-Fuentes[4], Ana Osa-Sáez[1], Luis Martínez-Dolz[1]

[1]Servicio de Cardiología. Hospital Universitari i Politècnic La Fe, Valencia ~ Valencia ~ Spain, [2]Servicio de Cardiología. Hospital de Manises. ~ Manises ~ Spain, [3]Servicio de Cardiología. Hospital Virgen de los Lirios. ~ Alcoi ~ Spain, [4]Servicio de Cardiología. Hospital Arnau de Vilanova. ~ Valencia ~ Spain

B46 SAFETY AND EFFICACY OF SUBCUTANEOUS TREPROSTINIL IN CONGENITAL HEART DISEASE- RELATED PULMONARY ARTERIAL HYPERTENSIONNika Skoro-Sajer*[1], Christian Gerges[1], Olga Hajnalka Balint[2], Monika Kaldararova[3], Iveta Simkova[3], Johannes Jakowitsch[1], Harald Gabriel[1], Helmut Baumgartner[4], Mario Gerges[1], Roela Sadushi-Kolici[1], David Celermajer[5], Irene Lang[1]

[1]Cardiology, Medical University of Vienna ~ Vienna ~ Austria, [2]György Gottsegen, Hungarian Institute of Cardiology ~ Budapest ~ Hungary, [3]Department of Cardiology and Angiology, Slovak Medical University and National Institute of Cardiovascular Diseases ~ Bratislava ~ Slovakia, [4]Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, ~ Münster ~ Germany, [5]Sydney Medical School, University of Sydney, ~ Sydney ~ Australia

B47 PARENTERAL USE OF PROSTANOIDS IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) IN A TERTIARY REFERRAL UNIVERSITY HOSPITALEleni Stagaki*, Andriana Papaioannou, Athanasios Pappas, Loukianos Rallidis, Dimitrios Konstantonis, Frantzeska Frantzeskaki, Iraklis Tsagkaris, John Lekakis, Spyros Papiris, Apostolos Armaganidis, Stylianos Orfanos, Anastasia AnthiPulmonary Hypertension Clinic, University of Athens, “Attikon” Hospital ~ Athens ~ Greece

B48 THE GOAL OF LONG-TERM OXYGEN THERAPY TO AVOID TISSUE HYPOXIA IN PATIENTS WITH PULMONARY HYPERTENSIONRika Suda*, Nobuhiro Tanabe, Akira Naito, Rintaro Nishimura, Takayuki Jujo, Toshihiko Sugiura, Seiichiro Sakao, Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan

B49 DIVERSITY OF BORDERLINE PULMONARY ARTERIAL PRESSURE ASSOCIATED WITH SYSTEMIC SCLEROSIS: 4 CASE SERIESEri Sugawara*[1], Masaru Kato[1], Ryo Hisada[1], Hiroyuki Nakamura[1], Fujieda Yuichiro[1], Kenji Oku[1], Toshiyuki Bohgaki[1], Shinsuke Yasuda[1], Hiroshi Ohira[2], Ichizo Tsujino[2], Masaharu Nishimura[2], Tatsuya Atsumi[1]

[1]Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University ~ Sapporo ~ Japan, [2]First Department of Medicine, Hokkaido University Hospital ~ Sapporo ~ Japan

B50 REAL LIFE EXPERIENCE WITH REVEAL RISK SCORE FOR PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONCelik Sumer*[1], Ahmet Kaya Bilge[2], Murat Inanc[4], Halim Issever[3], Gulfer Okumus[1]

[1]Istanbul University Medical Faculty Department of Pulmonary Diseases ~ Istanbul ~ Turkey, [2]Istanbul University Medical Faculty Department of Cardiology ~ Istanbul ~ Turkey, [3]Istanbul University Medical Faculty Department of Public Health ~ Istanbul ~ Turkey, [4]Istanbul University Medical Faculty Department of Rheumatology ~ Istanbul ~ Turkey

B51 INFLUENCE OF INITIAL RIOCIGUAT MONOTHERAPY AND TRANSITION FROM SILDENAFIL TO RIOCIGUAT THERAPY IN PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION ON RIGHT HEART REMODELING AND RIGHT VENTRICULAR – PULMONARY ARTERIAL COUPLING Irina Taran*[1], Anna Belevskaya[4], Marina Saidova[2], Tamila Martynyuk[3], Irina Chazova[5]

[1]Postgraduate student of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federatio, [2]

Dr. Med. Sci., Prof. Head of Department of Ultrasonic Diagnostic Techniques, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation ~, [3]Dr. Med. Sci., Head of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation, [4]

Physician of Ultrasonic Diagnostic Techniques Laboratory, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation ~ Moscow ~ Russian Fe, [5]

RAS Academician, Prof., Dr. Med. Sci., Director of Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Head of Department of Hypertension, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Res



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Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB52 THE VALUE OF CARDIOPULMONARY EXERCISE TESTING IN

ASSESSMENT OF THE SEVERITY OF PULMONARY ARTERIAL HYPERTENSION PATIENTS Irina Taran*[1], Zarina Valieva[2], Tamila Martynyuk[3], Irina Chazova[4]

[1]Postgraduate student of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federatio, [2]

PhD of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation ~ Moscow ~ Russ, [3]Dr. Med. Sci., Head of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation, [4]

RAS Academician, Prof., Dr. Med. Sci., Director of Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Head of Department of Hypertension, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Res

B53 ENHANCED GLUCOSE METABOLISM IN THE RIGHT VENTRICULAR WALL PREDICTS A PROGNOSTIC IMPACT IN PATIENTS WITH PULMONARY HYPERTENSIONNakamura Tomohisa*, Tahara Nobuhiro, Sugiyama Yoichi, Bekki Munehisa, Tahara Atsuko, Honda Akihiro, Kumagai Eita, Igata Sachiyo, Fukumoto YoshihiroDepartment of Internal Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine ~ Fukuoka ~ Japan

B54 HEMODYNAMIC EFFECTS OF THE ORAL PROSTACYCLIN (IP) RECEPTOR AGONIST RALINEPAG IN PULMONARY ARTERIAL HYPERTENSION (PAH)Fernando Torres*[9], Harrison Farber[1], Arsen D Ristic[2], Vallerie Mclaughlin[3], John Adams[4], Stewart Turner[4], Preston Klassen[4], Pilar Escribano-Subias[5], Namita Sood[6], Anne M Keogh[7], Lewis Rubin[8]

[1]Professor of Medicine and Director of the Pulmonary Hypertension Center, Boston University School of Medicine ~ Boston, MA ~ United States of America, [2]Professor of Internal Medicine and Cardiology, Belgrade University School of Medicine, Assistant Director, Department of Cardiology of the Clinical Center of Serbia, Coordinator of the National Registry on Pulmonary Hypertension ~ Belgrade ~ Serbia, [3]Kim A. Eagle, MD Endowed Professor of Cardiovascular Medicine, Director of Pulmonary Hypertension Program, University of Michigan ~ Ann Arbor, MI ~ United States of America, [4]Arena Pharmaceuticals ~ San Diego, CA ~ United States of America, [5]Departamento de Cardiologia, Hospital 12 de Octubre ~ Madrid ~ Spain, [6]University of Texas Health Science Center of Houston ~ Houston, TX ~ United States of America, [7]Department of Cardiology, St Vincent’s Hospital ~ Sydney ~ Australia, [8]Emeritus Professor of Medicine, University of California, San Diego School of Medicine, La Jolla, CA; Adjunct Professor of Medicine, Columbia University College of Physicians and Surgeons ~ New York, NY ~ United States of America, [9]Medical Director of Lung Transplantation, Head of Pulmonary Hypertension Program, UT Southwestern Medical Center, ~ Dallas, TX ~ United States of America

B55 IS REDUCED SYSTEMIC ARTERIAL STIFFNESS A NOVEL SURROGATE INDEX OF SEVERITY IN PATIENTS WITH GROUP 1 PULMONARY ARTERIAL HYPERTENSION?Helen Triantafyllidi*[1], Olympia Apostolopoulou[2], Benas Dimitris[1], Leonidas Palaiodimos[1], Mary Varoudi[1], George Pavlidis[1], Anastasia Anthi[2], Loukianos Rallidis[1], Orfanos Stylianos[2], Hraklis Tsagkaris[2], Ignatios Ikonomidis[1], Apostolos Armaganidis[2], John Lekakis[1]

[1]2nd Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital ~ Athens ~ Greece, [2]2nd Department of Critical Care, Medical School, University of Athens, ATTIKON Hospital ~ Athens ~ Greece

B56 THE ROLE OF SYSTEMIC ENDOTHELIAL GLYCOCALYX IN PATIENTS WITH GROUP 1 PULMONARY ARTERIAL HYPERTENSIONHelen Triantafyllidi*[1], Olympia Apostolopoulou[2], Dimitris Benas[1], Leonidas Palaiodimos[1], Mary Varoudi[1], George Pavlidis[1], Dimitris Kostantonis[2], Ignatios Ikonomidis[1], Stylianos Orfanos[2], Iraklis Tsagkaris[2], Anastasia Anthi[2], Apostolos Armaganidis[2], John Lekakis[1]

[1]2nd Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital ~ Athens ~ Greece, [2]2nd Department of Critical Care, Medical School, University of Athens, ATTIKON Hospital ~ Athens ~ Greece

B57 RIGHT ATRIUM ENLARGEMENT PREDICTS CLINICALLY SIGNIFICANT SUPRAVENTRICULAR ARRHYTHMIAS IN PULMONARY ARTERIAL HYPERTENSION.Marcin Waligóra*, Anna Tyrka, Jakub Stepniewski, Wojciech Magon, Piotr Podolec, Grzegorz KopecDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College at John Paul II Hospital ~ Krakow ~ Poland

B58 ELECTROCARDIOGRAPHIC CRITERIA OF RIGHT VENTRICULAR HYPERTROPHY REFLECT HEMODYNAMIC IMPROVEMENT IN PULMONARY HYPERTENSION.Marcin Waligóra*, Anna Tyrka, Jakub Stepniewski, Piotr Podolec, Grzegorz KopecDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College at John Paul II Hospital ~ Krakow ~ Poland

B59 STRUCTURAL AND FUNCTIONAL STATUS OF THE SYSTEMIC CIRCULATION ARTERIES IN PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION WITH DIFFERENT FUNCTIONAL ABILITIES AND ENDPOINTSIryna Zhyvylo*, Yevhen Titov, Ganna Radchenko, Yurii SirenkoNational Scientific Centre “Institute of Cardiology named after M.D.Strazhesko” of AMS of Ukraine ~ Kyiv ~ Ukraine



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Wednesday, February 28, 2018RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSIONB60 PROGNOSTIC VALUE OF ELECTROCARDIOGRAM IN PATIENTS

WITH IDIOPATHIC/HEREDITARY PULMONARY ARTERIAL HYPERTENSIONElisa Zuffa*, Fabio Dardi, Nikita Tanese, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Enrico Monti, Alessandra Albini, Daniele Guarino, Filippo Pasca, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

RIGHT VENTRICULAR ASSISTANCE AND LUNG TRANSPLANTATION B61 PERCUTANEOUS ATRIAL SEPTOSTOMY WITH PERIPHERAL

STENT IN A PATIENT WITH SYNCOPE AND REFRACTORY PULMONARY ARTERIAL HYPERTENSION AND MILD HYPOXIAVasil Velchev*St. Anna Hospital ~ Sofia ~ Bulgaria

TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSIONB62 POTENCY, SELECTIVITY, AND COMPARATIVE PLATELET AND

VASCULAR ACTIVITY OF RALINEPAG ACTING ON IP RECEPTORS IN HUMAN TISSUESJohn Adams*[3], Brendan Whittle[1], Lei Shen[2], Jigisha Patel[2], Lucie H Clapp[2]

[1]William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London ~ London ~ United Kingdom, [2]Institute of Cardiovascular Science, University College London ~ London ~ United Kingdom, [3]Arena Pharmaceuticals ~ San Diego, CA ~ United States of America

B63 SILDENAFIL ADDED TO PIRFENIDONE IN PATIENTS WITH ADVANCED IDIOPATHIC PULMONARY FIBROSIS (IPF) AND PULMONARY HYPERTENSION (PH): A PHASE IIB, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDYJürgen Behr*[1], Steven D Nathan[2], Sergio Harari[3], Wim Wuyts[4], Klaus-Uwe Kirchgaessler[5], Monica Bengus[5], Frank Gilberg[5], Athol U Wells[6]

[1]Department of Internal Medicine V, LMU and Asklepios Fachkliniken Gauting, Comprehensive Pneumology Center ~ Munich ~ Germany, [2]INOVA Heart and Vascular Institute, Inova Fairfax Hospital ~ Vienna, VA ~ United States of America, [3]

U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, MultiMedica IRCCS ~ Milan ~ Italy, [4]Department of Pulmonary Medicine, Unit for Interstitial Lung Diseases, University of Leuven ~ Leuven ~ Belgium, [5]F Hoffmann-La Roche, Ltd. ~ Basel ~ Switzerland, [6]Interstitial Lung Disease Unit, Royal Brompton Hospital ~ London ~ United Kingdom



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Wednesday, February 28, 2018TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSIONB64 INDIVIDUALIZED HOME-BASED EXERCISE PROGRAM FOR THE

IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTS: MULTIPLE CASE STUDYLina Butane*, Daina Šmite, Andris SkrideLatvian ~ Riga ~ Latvia

B65 UDENAFIL FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSIONHyuk Jae Chang*[1], Shin-Jeong Song[1], Sung-A Chang[2], Hyung Kwan Kim[3], Duk-Kyung Kim[2]

[1]Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul ~ Seoul ~ Korea, Republic of, [2]Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine ~ Seoul ~ Korea, Republic of, [3]Department of Cardiology, Seoul National University Hospital, Seoul, South Korea ~ Seoul ~ Korea, Republic of

B66 ACUTE HEMODYNAMIC CHANGES AFTER SINGLE ADMINISTRATION OF UDENAFIL IN PULMONARY ARTERIAL HYPERTENSION (PHASE IIA STUDY)Sung-A Chang*[3], Hyung-Kwan Kim[1], Hyuk Jae Chang[2], Duk-Kyung Kim[3]

[1]Seoul National University Hospital ~ Seoul ~ Korea, Republic of, [2]Yonsei Severance Hospital ~ Seoul ~ Korea, Republic of, [3]Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine ~ Seoul ~ Korea, Republic of

B67 BASELINE AND DEMOGRAPHIC DATA ON THE FIRST 150 PATIENTS FROM SPHERE (UPTRAVI® [SELEXIPAG]: THE USERS DRUG REGISTRY)Kelly Chin*[1], Kristin Highland[2], Nick H Kim[3], Murali Chakinala[4], Anna Hemnes[5], Harrison Farber[6], Carol Zhao[7], Mike Keating[8], Brian Hartline[7], Johanna Colvin[7], Vallerie Mclaughlin[9]

[1]Pulmonary and Critical Care Division, University of Texas Southwestern Medical Center ~ Dallas ~ United States of America, [2]Cleveland Clinic ~ Cleveland ~ United States of America, [3]Division of Pulmonary and Critical Care Medicine, University of California San Diego ~ La Jolla ~ United States of America, [4]Washington University School of Medicine ~ St. Louis ~ United States of America, [5]Vanderbilt University Medical Center ~ Nashville ~ United States of America, [6]Boston University School of Medicine ~ Boston ~ United States of America, [7]Actelion Pharmaceuticals US ~ South San Francisco ~ United States of America, [8]Actelion Pharmaceuticals US ~ South San Francisco ~ United States of America, [9]University of Michigan Medical Center ~ Ann Harbor ~ United States of America

B68 ERS TASK FORCE: EXERCISE TRAINING AND REHABILITATION IN PATIENTS WITH SEVERE CHRONIC PULMONARY HYPERTENSIONEkkehard Grünig*[1], Christina Eichstaedt[1], Joan-Albert Barberà[2], Isabel Blanco[2], Eduardo Bossone[3], Antonio Cittadini[3], Marion Delcroix[4], Sean Gaine[5], Stefano Ghio[6], Lina Gumbiene[7], Frances Handoko De Man[8], Martin Johnson[9], David Kiely[11], Gabor Kovacs[12], Alison Mackenzie[9], Robert Naeije[10], Silvia Ulrich[13], Horst Olschewski[12], Abílio Reis[14], Mário Santos[14], Anton Vonk Noordegraaf[8], Andrew Peacock[9]

[1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]2. Hospital Clinic at the University of Barcelona ~ Barcelona ~ Spain, [3]Department of Cardiac Surgery, University Hospital Salerno ~ Salerno ~ Italy, [4]Department of Pneumology, University Hospital Leuven ~ Leuven ~ Belgium, [5]Department of Pulmonology, Mater Misericordiae University Hospital ~ Dublin ~ Ireland, [6]Division of Cardiology, Università degli studi di Pavia ~ Pavia ~ Italy, [7]

Department of Cardiovascular Medicine, Vilnius University Hospital Santaros Klinikos ~ Vilnius ~ Lithuania, [8]Department of Pulmonology, VU University Medical Center Amsterdam ~ Amsterdam ~ Netherlands, [9]Golden Jubilee Hospital ~ Glasgow ~ United Kingdom, [10]Department of Cardiology, University Clinic Brussels - Erasme Hospital ~ Brussels ~ Belgium, [11]Department of Respiratory Medicine, Royal Hallamshire Hospital ~ Sheffield ~ United Kingdom, [12]Department Internal Medicine, Medical University of Graz ~ Graz ~ Austria, [13]Centre for Pulmonary Hypertension, University Hospital Zurich ~ Zurich ~ Switzerland, [14]14. Department of Internal Medicine, Hospital Geral de Santo António ~ Porto ~ Portugal, [15]Cardiology and Pneumology ~ Europe ~ United Kingdom

B69 ADVANCED CORRECTIVE TREATMENT USING PULMONARY VASOREACTIVITY TESTING IN PATIENTS WITH EISENMENGER SYNDROME WITH CONGENITAL HEART DISEASES; RETROSPECTIVE STUDY IN SINGLE CENTER Jo Won Jung*, Se Yong Jung, Jae Young Choi, Yu Lim Shin, Han Ki Park, Young Hwan ParkYonsei University College of Medicine ~ Seoul ~ Korea, Republic of

B70 CONTINUOUS S.C. DIURETIC THERAPY AT HOME IMPROVES QUALITY OF LIFE IN END-STAGE PAHMiriam Kap*Erasmus MC ~ Rotterdam ~ Netherlands

B71 BENEFICIAL EFFECTS OF FERRIC CARBOXYMALTOSE IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION AND IRON DEFICIENCY: A LONG-TERM PILOT STUDYTilmann Kramer*, Kristiana Natsina, Thomas Viethen, Felix Gerhardt, Daniel Dumitrescu, Stephan Baldus, Stephan RosenkranzKlinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Germany ~ Köln ~ Germany



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Wednesday, February 28, 2018TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSIONB72 IDENTIFICATION OF CELASTRAMYCIN AS A NOVEL

THERAPEUTIC AGENT FOR PULMONARY ARTERIAL HYPERTENSIONRyo Kurosawa*, Satoh Kimio, Nobuhiro Kikuchi, Taijyu Satoh, Junichi Omura, Masamichi Nogi, Shinichiro Sunamura, Tomohiro Otshuki, Nobuhiro Yaoita, Mohammad Abdul Hai Siddique, Md Elias Al-Mamun, Toru Shimizu, Hiroaki ShimokawaTohoku University ~ Sendai ~ Japan

B73 CHRONIC TRANSFUSION EXCHANGES IN THE MANAGEMENT OF SICKLE CELL DISEASE-ASSOCIATED PRECAPILLARY PULMONARY HYPERTENSION: A PILOT STUDYTurpin Matthieu*, Parent Florence, Jais Xavier, Montani David, Sitbon Olivier, Humbert Marc, Simonneau Gerald, Savale LaurentService de pneumologie - CHU Bicêtre ~ Le Kremlin Bicêtre ~ France

B74 SAFETY AND EFFICACY OF IMMUNOADSORPTION AS AN ADD-ON TO MEDICAL TREATMENT IN PATIENTS WITH SEVERE IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION (IPAH)Christian Nagel*[2], Benjamin Egenlauf[1], Ralf Ewert[3], Hans Lehmkuhl[4], Stephan Rosenkranz[5], Nicola Benjamin[1], Vedat Schwenger[6], Felix Herth[7], Ekkehard Grünig[1]

[1]Centre for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]Lung Centre, Klinikum Mittelbaden ~ Baden-Baden ~ Germany, [3]Clinic for Internal Medicine, Greifswald University Hospital ~ Greifswald ~ Germany, [4]Medical Practice for Cardiology, Augustenburger Platz 1 ~ Berlin ~ Germany, [5]Department of Cardiology, Heart Center at the University Hospital Cologne and Cologne Cardiovascular Research Center ~ Cologne ~ Germany, [6]Department of Nephrology, Klinikum Stuttgart ~ Stuttgart ~ Germany, [7]Department of Internal Medicine, Pulmonology and Critical Care Medicine, Thorax Clinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany

B75 PRECLINICAL AND PHASE 1 CLINICAL CHARACTERIZATION OF LIQ861, A NEW DRY POWDER FORMULATION OF TREPROSTINILMike Royal*[1], Robert Roscigno[1], Toby Vaughn[1], Stephanie Anderson[1], William Wargin[2], Rex Williams[1], Clint Forsythe[3], Thomas Hunt[3], Patrick Normand[5], Manal Hantash[5], John Dillberger[4]

[1]Liquidia Technologies ~ RTP ~ United States of America, [2]Nuventra, Inc. ~ Durham, NC ~ United States of America, [3]PPD Development, LLC ~ Austin, TX ~ United States of America, [4]J. Dillberger LLC ~ Nashville, IN ~ United States of America, [5]ITR Laboratories ~ Montreal, Quebec ~ Canada

B76 IDENTIFICATION OF EMETINE AS A NOVEL THERAPEUTIC AGENT FOR PULMONARY HYPERTENSION IN RATS -HIGH-THROUGHPUT SCREENING OF 5,562 COMPOUNDS-Mohammad Abdul Hai Siddique*, Kimio Satoh, Ryo Kurosawa, Md Elias Al- Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Hiroaki ShimokawaDepartment of Cardiovascular Medicine ~ Sendai ~ Japan

B77 PYRIDOXAMINE ATTENUATED THE SMOOTH MUSCLE CELL PROLIFERATION AND HEMODYNAMIC AGGRAVATION IN THE PULMONARY ARTERY HYPERTENSION ANIMAL MODELKuk Hui Son*[1], Seyeon Oh[1], Seungbum Choi[1], Kyung-Hee Kim[2], Minsu Kim[1], Hanul Choi[1], Jeongwon Ryu[3], Kyunghee Byun[1], Wook-Jin Chung[1]

[1]Gachon Cardiovascular Research Institute, Gachon University ~ Incheon ~ Korea, Republic of, [2]Departement of Cardiology, Sejong General Hospital ~ Bucheon ~ Korea, Republic of, [3]Advanced Medical Technology Laboratory Healcerion Co., Ltd ~ Seoul ~ Korea, Republic of

B78 THE MOTION STUDY: A RESPONDER ANALYSIS OF RIOCIGUAT Namita Sood*[1], Alvaro Aranda[2], David Platt[3], Larose Anneliese[3], Frank Kleinjung[4], Gerald O’brien[3]

[1]The Ohio State University ~ Colombus ~ United States of America, [2]CardioPulmonary Research Center ~ San Juan ~ Puerto Rico, [3]Bayer Pharmaceuticals, Inc. ~ Whippany ~ United States of America, [4]Bayer Pharmaceuticals, Inc. ~ Berlin ~ Germany



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POSTER SESSIONS

Wednesday, February 28, 2018PH DUE TO LEFT HEART DISEASESB79 HEMODYNAMIC PREDICTORS OF ACUTE RIGHT HEART FAILURE

AFTER HEART TRANSPLANTATION (HT). EMERGING ROLE OF PULMONARY ARTERY COMPLIANCE (PAC)Oscar Aguirre-Zurita*, David Galvez, Walter Alarco, Oscar Guerrero, Miguel Lescano, Christian Soplopuco, Ruth Villarroel, Ana SihuayroINCOR ~ LIMA ~ Peru

B80 PDE-5 INHIBITORS FOR PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE: POTENTIAL BENEFIT?Hayley Barnes*[1], Zoe Brown[2], Andrew Burns[3], Trevor Williams[1]

[1]Alfred Hospital ~ Melbourne ~ Australia, [2]Royal Adelaide Hospital ~ Adelaide ~ Australia, [3]Department of Cardiology, St Vincent’s Hospital ~ Melbourne ~ Australia

B81 CLINICAL PHENOTYPES, VENTILATORY RESPONSES TO EXERCISE AND OUTCOMES OF PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE: ROLE OF THE PRE-CAPILLARY COMPONENTSergio Caravita*[3], Andrea Faini[1], Sandy Carolino D’Araujo[2], Céline Dewachter[2], Laura Chomette[2], Antoine Bondue[2], Robert Naeije[2], Gianfranco Parati[1], Jean-Luc Vachiéry[2]

[1]Dept of Cardiovascular, Neural, and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano ~ Milano ~ Italy, [2]Dept of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme ~ Bruxelles ~ Belgium, [3]Dept of Cardiovascular, Neural, and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano; Dept of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme ~ Milano ~ Italy

B82 DYSREGULATION OF WNT-RELATED SIGNALING PATHWAY CORRELATES WITH THE DEVELOPMENT OF PH SECONDARY TO LEFT VENTRICULAR DYSFUNCTIONZen-Kong Dai*, I-Chen Chen, Jong-Hau HsuDept. of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University ~ Kaohsiung ~ Taiwan

B83 A NEW SCORE TO DIFFERENTIATE IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION FROM PULMONARY HYPERTENSION DUE TO HEART FAILURE WITH PRESERVED EJECTION FRACTIONFabio Dardi*[1], Nikita Tanese[1], Sergio Caravita[2], Andrea Rinaldi[1], Celine Dewachter[3], Enrico Gotti[1], Thomas Nguyen[3], Enrico Monti[1], Alessandra Albini[1], Massimiliano Palazzini[1], Alessandra Manes[1], Jean Luc Vachiery[3], Nazzareno Galiè[1]

[1]University of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy, [2]IRCCS Ospedale S. Luca ~ Milano ~ Italy, [3]Pulmonary Hypertension and Heart Failure Clinic - CUB Hop Erasme ~ Brussels ~ Belgium

B84 PATHOPHYSIOLOGY OF PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE – A HEMODYNAMIC STUDYChristian Gerges*[1], Mario Gerges[1], Pierre Fesler[2], Anna-Maria Pistritto[3], David Celermajer[4], Irene Lang[1]

[1]Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna ~ Vienna ~ Austria, [2]PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, and Department of Internal Medicine, Lapeyronie Hospital ~ Montpellier ~ France, [3]Division of Cardiology, Ferrarotto Hospital, University of Catania ~ Catania ~ Italy, [4]Department of Cardiology, Sydney Medical School, University of Sydney ~ Sydney ~ Australia

B85 EFFECTS OF CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION ON PULMONARY HAEMODYNAMICS IN ADVANCED HEART FAILURE PATIENTSAda Francesca Giglio*[1], Luciana D’’Angelo[1], Enrico Perna[1], Enrico Ammirati[1], Francesca Macera[1], Manlio Gianni Cipriani[1], Fabrizio Oliva[2], Andrea Garascia[1], Claudio Russo[2], Maria Frigerio[1]

[1]2nd Section of Cardiology-Heart Failure and Transplantation, De Gasperis CardioCenter, Niguarda Hospital, Milan, Italy. ~ Milano ~ Italy, [2]De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda Ca’ Granda, Milan, Italy ~ Milano ~ Italy

B86 GENETIC ANALYSIS AND CHAMBER SPECIFIC GENE EXPRESSION ANALYSIS IN PATIENTS WITH CPC-PH AND IPC-PHHidetaka Kioka*, Yoshihiro Asano, Ayako Takuwa, Yohei Miyashita, Hiroshi Miyawaki, Tomohito Ohtani, Yoshiki Sawa, Keiko Yamauchi-Takihara, Yasushi SakataOsaka University Graduate School of Medicine ~ Suita ~ Japan

B87 THERAPEUTIC POTENTIAL OF PHOSPHODIESTERASE TYPE 5 INHIBITORS IN HEART FAILURE WITH PRESERVED EJECTION FRACTION AND COMBINED POST- AND PRE-CAPILLARY PULMONARY HYPERTENSIONTilmann Kramer*[2], Kristina Orlova[2], Felix Gerhardt[2], Daniel Dumitrescu[2], Henrik Ten Freyhaus[2], Martin Hellmich[1], Stephan Baldus[2], Stephan Rosenkranz[2]

[1]Institut für Medizinische Statistik, Informatik und Epidemiologie (IMSIE), Universität zu Köln, Germany ~ Köln ~ Germany, [2]Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Germany ~ Köln ~ Germany

B88 PRESENCE OF PULMONARY HYPERTENSION IS A POOR PROGNOSTIC FACTOR IN PATIENTS WITH PRIMARY MITRAL REGURGITATION NOT IN SECONDARY MITRAL REGURGITATIONJu-Hee Lee*[1], Jae-Hyeong Park[2], Hee-Jin Kwon[2], Seok-Woo Seong[2], Jin Kyung Ohh[2], Myeong-Chan Cho[2]

[1]Chungbuk National University Hospital ~ Cheongju ~ Korea, Republic of, [2]Chungnam National University ~ Daejeon ~ Korea, Republic of



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Wednesday, February 28, 2018PH DUE TO LEFT HEART DISEASESB89 FLUID CHALLENGE DURING RIGHT HEART CATHETERIZATION:

AN EXPERIENCE FROM A TERTIARY PULMONARY HYPERTENSION REFERRAL CENTRENima Moghaddam*[1], John Swiston[1], Robert D Levy[1], Lisa Lee[2], Victor F Huckell[1], Nathan W Brunner[1]

[1]University of British Columbia ~ Vancouver ~ Canada, [2]Vancouver Coastal Health ~ Vancouver ~ Canada

B90 EFFECT OF IMPROVEMENT OF PULMONARY HYPERTENSION AND/OR LEFT VENTRICULAR SYSTOLIC FUNCTION ON THE LONG-TERM PROGNOSIS OF PATIENTS WITH PULMONARY HYPERTENSION WITH LEFT VENTRICULAR SYSTOLIC DYSFUNCTIONJae-Hyeong Park*[3], Ju-Hee Lee[1], Hee-Jin Kwon[2]

[1]Chungbuk National University Hospital ~ Cheongju ~ Korea, Republic of, [2]Chungnam National University ~ Daejeon ~ Korea, Republic of, [3]~ Korea, Republic of

B91 COMPARATIVE OUTCOME OF INCIDENT PATIENTS WITH PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE ACCORDING WITH THE HAEMODYNAMIC CLASSIFICATION OF THE 2015 ESC-ERS PULMONARY HYPERTENSION GUIDELINESFilippo Pasca*, Fabio Dardi, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Alessandra Albini, Enrico Monti, Elisa Zuffa, Daniele Guarino, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized, Diagnosticand Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

B92 NEDA PH-LHD PREDICTIVE MODEL: VALIDATION OF DIASTOLIC MARKERS OF PULMONARY HYPERTENSION WITH RIGHT HEART CATHETERISATION Geoff Strange*[1], David Playford[1], Pyi Naing[1], Jim Codde[1], David Celermajer[2], Gregory Scalia[3], Kevin Chung[1]

[1]The University of Notre Dame ~ Fremantle ~ Australia, [2]The University of Sydney ~ Sydney ~ Australia, [3]The University of Queensland ~ Brisbane ~ Australia

B93 RHO-KINASE AND CYCLOPHILIN A AS NOVEL THERAPEUTIC TARGETS FOR CARDIAC DIASTOLIC DYSFUNCTION AND POST-CAPILLARY PULMONARY HYPERTENSIONShinichiro Sunamura*, Kimio Satoh, Ryo Kurosawa, Tomohiro Ohtsuki, Nobuhiro Kikuchi, Mohammad Elias-Al-Mamun, Toru Shimizu, Shohei Ikeda, Kota Suzuki, Taijyu Satoh, Junichi Omura, Masamichi Nogi, Mohammad Abdul Hai Siddique, Satoshi Miyata, Hiroaki ShimokawaDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan

B94 MEAN VELOCITY OF THE PULMONARY ARTERY AS AN EARLY PROGNOSTIC INDICATOR IN HFREF IN RELATION WITH FIBROSIS BIOMARKERS GALECTIN-3 AND ST2/IL-1.Blanca Trejo-Velasco*[1], Oscar Fabregat-Andrés[1], Maria Pilar García-González[2], Monica Ferrando[1], Diana Perdomo-Londoño[1], Joaquina Belchi[1], Cristina Albiach-Montañana[1], Sergio Sánchez-Álvarez[1], Juan Pablo Cardenas-Tealdo[1], Salvador Morell-Cabedo[1], Francisco Ridocci-Soriano[1]

[1]Hospital General Universitario de Valencia ~ Valencia ~ Spain, [2]Centro Médico Eresa Valencia ~ Valencia ~ Spain

B95 A RARE AND RAPIDLY PROGRESSING CASE OF PULMONARY HYPERTENSIONYalin Tolga Yaylali*, Sonmez GokhanPamukkale University ~ Denizli ~ Turkey



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POSTER SESSIONS

Thursday, March 1, 2018PH DUE TO CHRONIC LUNG DISEASESC10 A POTENTIAL ROLE FOR PDE-5 INHIBITORS FOR PULMONARY

HYPERTENSION DUE TO LUNG DISEASE/HYPOXIAHayley Barnes*[1], Zoe Brown[2], Andrew Burns[3], Trevor Williams[1]

[1]Alfred Hospital ~ Melbourne ~ Australia, [2]Royal Adelaide Hospital ~ Adelaide ~ Australia, [3]Department of Cardiology, St Vincent’s Hospital ~ Melbourne ~ Australia

C11 SEVERE PULMONARY HYPERTENSION IN TOBACCO-INDUCED RESPIRATORY DISEASESSamy Chelabi*[1], Guillaume Chassagnon[2], Laurent Savale[1], Jason Weatherald[5], Xavier Jais[1], Athenais Boucly[1], Herve Mal[4], Pierre-Regis Burgel[3], Gerald Simonneau[1], Olivier Sitbon[1], Marc Humbert[1], David Montani[1]

[1]APHP, Service de pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]APHP, Service de radiologie, Hôpital Cochin ~ Paris ~ France, [3]APHP, Service de pneumologie, Hôpital Cochin ~ Paris ~ France, [4]APHP, Service de pneumologie, Hôpital Bichat ~ Paris ~ France, [5]Department of Medecine, University of Calgary ~ Calgary ~ Canada

C12 COMPARATIVE OUTCOME OF INCIDENT PATIENTS WITH PULMONARY HYPERTENSION DUE TO LUNG DISEASE ACCORDING WITH THE HAEMODYNAMIC CLASSIFICATION OF THE 2015 ESC-ERS PULMONARY HYPERTENSION GUIDELINESDaniele Guarino*, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Fabio Dardi, Alessandra Albini, Enrico Monti, Elisa Zuffa, Filippo Pasca, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

C13 INHALED ILOPROST AS POTENTIAL NEW TREATMENT FOR GROUP 3 PULMONARY HYPERTENSIONChih-Hsin Hsu*, Po-Lan SuDepartment of Internal Medicine, National Cheng Kung University Hospital ~ Tainan ~ Taiwan

C14 PROGNOSTIC FACTORS OF PULMONARY HYPERTENSION WITH SEVERE LUNG DISEASE IN RETROSPECTIVE STUDYNakayama Kazuhiko*, Emoto Noriaki, Tamada Naoki, Shinkura Yuto, Onishi Hiroyuki, Yanaka Kenichi, Matsuoka Yoichiro, Shinke Toshiro, Hirata Ken-IchiKobe University Graduate School of Medicine ~ Kobe ~ Japan

C15 ESTABLISHMENT OF A NOVEL MODEL OF GROUP 3 PULMONARY HYPERTENSION INDUCED BY SU5416/HYPOXIA IN RATSYosuke Wada*, Kitaguchi Yoshiaki, Yasuo Masanori, Hanaoka MasayukiFirst Department of Internal Medicine, Shinshu University School of Medicine ~ Matsumoto ~ Japan

C16 A RARE RESPIRATORY CONDITION ASSOCIATED WITH PULMONARY HYPERTENSIONYalin Tolga Yaylali*, Sinan Durmus, Alperen Emre Akgun, Fatma EvyapanPamukkale University ~ Denizli ~ Turkey

CTEPHC17 BALLOON PULMONARY ANGIOPLASTY(BPA) AS AN

ADDITIONAL TREATMENT OPTION FOR PATIENTS WITH INOPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH) TREATED WITH RIOCIGUAT.Shiro Adachi*[1], Nakano Yoshihisa[1], Tajima Fumitaka[2], Shimokata Shigetake[1], Kamimura Yoshihiro[1], Okumura Naoki[1], Murohara Toyoaki[1], Kondo Takahisa[1]

[1]Nagoya university graduate school of medicine ~ nagoya ~ Japan, [2]Nagoya university hospital ~ Nagoya ~ Japan

C18 SUBMASSIVE PULMONARY EMBOLISM TREATMENT WITH ULTRASOUND-ACCELERATED THROMBOLYSIS (SPEAR) TRIAL: A PROSPECTIVE STUDY.Wael Berjaoui*, Michael Knox, Reda Girgis, David LangholzSpectrum Health ~ Grand Rapids ~ United States of America

C19 PREVALENCE AND LONG TERM OUTCOME OF CTEPH - SINGLE CENTRE EXPERIENCE.Marcela Bohacekova*, Tatiana Valkovicova, Monika Kaldararova, Iveta SimkovaDepartment of Cardiology and Angiology, Medical Faculty, Slovak Medical University and National Institute of Cardiovascular Diseases, ~ Bratislava ~ Slovakia



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POSTER SESSIONS

Thursday, March 1, 2018CTEPHC20 IS SUBDURAL HAEMORRHAGE AFTER PULMONARY

ENDARTERECTOMY UNDER-ESTIMATED?Alicia Xue Fen Chia*[1], Jonathan Yap[1], Wen Ruan[1], Kenny Wei-Tsen Loh[2], Foong Koon Cheah[2], Ai Leen Ang[2], Ghee Chee Phua[2], Duu Wen Sewa[2], Ju Le Tan[1], David Jenkins[3], Victor Tar Toong Chao[1], Soo Teik Lim[1]

[1]National Heart Centre Singapore ~ Singapore ~ Singapore, [2]Singapore General Hospital ~ Singapore ~ Singapore, [3]Papworth Hospital ~ Cambridge ~ United Kingdom

C21 ABSENCE OF THE FACTOR V LEIDEN MUTATION AND GENETIC RISK FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONMark Dodson*[2], Kelli Sumner[1], Jadyn Sanders[1], Lynette Brown[2], Scott Stevens[2], Scott Woller[2], Hunter Best[1], Gregory Elliott[2]

[1]ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories ~ Salt Lake City, UT ~ United States of America, [2]Department of Medicine, Intermountain Medical Center ~ Murray, UT ~ United States of America

C22 EFFECT OF BALLOON PULMONARY ANGIOPLASTY ON RIGHT VENTRICULAR AFTERLOAD IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONChristian Gerges*[1], Mario Gerges[1], Nika Skoro-Sajer[1], Roela Sadushi-Kolici[1], Bernhard Moser[2], Shahrokh Taghavi[2], Walter Klepetko[2], Hiromi Matsubara[3], Irene Lang[1]

[1]Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, General Hospital ~ Vienna ~ Austria, [2]Department of Surgery, Division of Thoracic Surgery, Medical University of Vienna, Vienna General Hospital ~ Vienna ~ Austria, [3]Department of Cardiology, Okayama Medical Center ~ Okayama ~ Japan

C23 VENTILATION/PERFUSION SCINTIGRAPHY FOR THE DIAGNOSIS OF CTEPH AFTER SPLENECTOMYMario Gerges*[4], Christian Gerges[4], Karanikas Georgios[1], Wolfgang Birkfellner[2], Isolde Maria Weinberg[2], Ilse Schwarzinger[3], Max Publig[3], Nika Skoro-Sajer[4], Maria Frey[4], Michael Schaffarich[2], Johannes Jakowitsch[4], Klaus Lechner[5], Bernhard Moser[6], Taghavi Sharokh[6], Walter Klepetko[6], Marcus Hacker[1], Irene Marthe Lang[4]

[1]Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [2]Center for Medical Physics and Biomedical Engineering, Vienna General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [3]Department of Laboratory Medicine, Division of Medical-Chemical Laboratory Diagnostics, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [4]Department of Internal Medicine II, Division of Cardiology, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [5]

Department of Internal Medicine I, Division of Haematology, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [6]Department of Surgery, Division of Thoracic Surgery, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria

C24 EXPERIENCE OF ONE YEAR OF BALLOON PULMONARY ANGIOPLASTY IN A SINGLE CENTER: SAFETY AND SHORT TERM RESULTSEnrico Gotti*, Massimiliano Palazzini, Andrea Rinaldi, Fabio Dardi, Enrico Monti, Alessandra Albini, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

C25 EXERCISE RIGHT HEART CATHETERIZATION IN PATIENTS WITH CHRONIC THROMBOEMBOLIC DISEASE – THERE IS A NEED FOR DEFINITION OF EXERCISE PULMONARY HYPERTENSIONStefan Guth*[1], Christoph Wiedenroth[1], Rieth Andreas[1], Christoph Liebetrau[1], Manuel Richter[2], Hossein Ardeschir Ghofrani[1], Eckhard Mayer[1]

[1]Kerckhoff-Clinic ~ Bad Nauheim ~ Germany, [2]University Clinic Giessen ~ Giessen ~ Germany

C26 END-STAGE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: UNIQUE MOLECULAR AND HISTOPATHOLOGICAL IMPRINTDijana Iloska*[1], Jochen Wilhelm[2], Stefan Guth[3], Rajkumar Savai[1], Ralph Schermuly[2], Ludger Fink[2], Werner Seeger[1], Eckhard Mayer[3], Soni Pullamsetti Savai[1]

[1]Max-Planck-Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, [2]

Department of Internal Medicine, Universities of Giessen and Marburg Lung Center ~ Giessen ~ Germany, [3]Kerckhoff-Klinik ~ Bad Nauheim ~ Germany

C27 USEFULNESS OF PERCUTANEOUS TRANSLUMINAL PULMONARY ANGIOPLASTY FOR CHRONIC PULMONARY THROMBOEMBOLIC DISEASETakumi Inami*[1], Masaharu Kataoka[2], Yohei Shigeta[1], Kaori Takeuchi[1], Hanako Kikuchi[1], Ayumi Goda[1], Haruhisa Ishiguro[1], Hideaki Yoshino[1], Toru Satoh[1]

[1]Kyorin University School of Medicine ~ Tokyo ~ Japan, [2]Keio University School of Medicine ~ Tokyo ~ Japan

C28 THE RELATIONSHIP BETWEEN THE DIAMETER OF BRONCHIAL ARTERIES AND THE RISK OF PULMONARY EDEMA OR AIRWAY BLEEDING FOR PULMONARY ENDARTERECTOMYTakayuki Jujo*, Tanabe Nobuhiro, Sakao Seiichiro, Akira Naito, Suda Rika, Kasai Hajime, Nishimura Rintaro, Sugiura Toshihiko, Ishida Keiichi, Tatsumi KoichiroGraduated School of Medicine, Chiba University ~ Chiba ~ Japan



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Thursday, March 1, 2018CTEPHC29 HOW DIFFERENT IS CENTRAL VERSUS PERIPHERAL CTEPH?

Monika Kaldararova*[1], Marcela Bohacekova[1], Jozef Pacak[1], Tatiana Valkovicova[1], Anna Remkova[2], Pavel Jansa[3], Jaroslav Lindner[4], Iveta Simkova[1]

[1]Department of Cardiology and Angiology, Slovak Medical University and National Institute of Cardiovascular Diseases ~ Bratislava ~ Slovakia, [2]Department of Internal Medicine, Slovak Medical University ~ Bratislava ~ Slovakia, [3]Center for Pulmonary Hypertension, General Teaching Hospital and Ist Faculty of Medicine of Charles University ~ Prague ~ Czech Republic, [4]2nd Surgical Department-Department of Cardiovascular Surgery, General University Hospital and the First Faculty of Medicine, Charles University ~ Prague ~ Czech Republic

C30 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN FIRSTLY DIAGNOSED PULMONARY EMBOLISM: INCIDENCE, PREDICTORS, AND PROGNOSTIC IMPLICATIONSKye Hun Kim*, Hyukjin Park, Jae Yeong Cho, Hyun Ju Yoon, Jong Chun ParkChonnam National University Hospital ~ Gwangju ~ Korea, Republic of

C31 FEASIBILITY AND SAFETY OF SHORTENING HOSPITAL STAY IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION TREATED WITH BALLOON PULMONARY ANGIOPLASTYMai Kimura*, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Toshimitsu Tsugu, Sarasa Isobe, Shinsuke Yuasa, Yuji Itabashi, Mitsushige Murata, Keiichi FukudaDepartment of Cardiology, Keio University School of Medicine ~ Tokyo ~ Japan

C32 EVALUATION OF HEMODYNAMIC RESPONSES TO EXERCISE IN PATIENTS WITH CTEPH AFTER BALLOON PULMONARY ANGIOPLASTYSugimura Koichiro*, Aoki Tatsuo, Tatebe Shunsuke, Yamamoto Saori, Yaoita Nobuhiro, Sato Haruka, Kozu Katsuya, Konno Ryo, Shimokawa HiroakiDepartment of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan

C33 CHANGES IN VESSEL DIAMETER AND LOCAL ELASTIC PROPERTIES OF PULMONARY ARTERIES AFTER BALLOON PULMONARY ANGIOPLASTY.Wojciech Magon*, Jakub Stepniewski, Marcin Waligóra, Kamil Jonas, Piotr Podolec, Grzegorz KopecDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College at John Paul II Hospital ~ Krakow ~ Poland

C34 3D PRINTING IN PATIENTS WITH PULMONARY HYPERTENSION Athanasios Manginas*[1], Georgios Bobas[2]

[1]Mediterraneo Hospital ~ Athens ~ Greece, [2]Univ. of Dundee ~ Dundee ~ United Kingdom

C35 DRUG-DRUG INTERACTION EVALUATION BETWEEN DIRECT ORAL ANTICOAGULANTS AND PHOSPHODIESTERASE-5 INHIBITORS: A POTENTIAL RISK FOR PULMONARY HYPERTENSION PATIENTS?Victor Margelidon-Cozzolino*[1], Sophie Hodin[2], Xavier Delavenne[2], Laurent Bertoletti[3]

[1]INSERM U1059, laboratoire SAINBIOSE ~ Saint-Priest-en-Jarez ~ France, [2]Faculté de Médecine de Saint-Etienne ~ Saint-Etienne ~ France, [3]Centre Hospitalier Universitaire de Saint-Etienne ~ Saint-Priest-en-Jarez ~ France

C36 PULMONARY ENDARTERECTOMY: BOLOGNA UNIVERSITY EXPERIENCESofia Martin-Suarez*[1], Gregorio Gliozzi[1], Nazzareno Galiè[2], Davide Pacini[1]

[1]Cardiac Surgery Dept. S.Orsola Hospital ~ Bologna ~ Italy, [2]Dept. of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University ~ Bologna ~ Italy

C37 MULTI-STEP THERAPY WITH RIOCIGUAT, BALLOON PULMONARY ANGIOPLASTY, AND CARDIAC REHABILITATION FOR INOPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONTakeshi Ogo*, Shigefumi Fukui, Yoichi Goto, Nao Konagai, Ryotaro Asano, Jin Ueda, Akihiro Tsuji, Yoshiaki Morita, Michio Nakanishi, Keiichi Fukuda, Satoshi Yasuda, Michio NakanishiNational Cerebral and Cardiovascular Centre ~ Osaka ~ Japan

C38 RESIDUAL RIGHT VENTRICULAR REMODELING FOLLOWING BALLOON PULMONARY ANGIOPLASTY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONTakeshi Ogo*[1], Ryotaro Asano[1], Ohta-Ogo Keiko[2], Shigefumi Fukui[1], Akihiro Tsuji[1], Jin Ueda[1], Nao Konagai[1], Keiichi Fukuda[3], Yoshiaki Morita[3], Satoshi Yasuda[1]

[1]Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center ~ Osaka ~ Japan, [2]Department of Pathology, National Cerebral and Cardiovascular Center ~ Osaka ~ Japan, [3]Department of Radiology, National Cerebral and Cardiovascular Center ~ Osaka ~ Japan

C39 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION ASSOCIATED WITH CHRONIC SYNTHETIC CANNABINOIDS ‘BONZAI’ USEGül Öngen*[1], Ersan Atahan[1], Burçak Kiliçkiran Avci[3], Bedrettin Yildizeli[2]

[1]Istanbul University, Cerrahpasa Medical Faculity, Pulmonary Deparment ~ Istanbul ~ Turkey, [2]Marmara University, Marmara Medical School, Thoracic Surgery ~ Istanbul ~ Turkey, [3]Istanbul University, Cerrahpasa Medical Faculity, Cardiology Deparment ~ Istanbul ~ Turkey



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Thursday, March 1, 2018CTEPHC40 PULMONARY BLOOD VOLUME BY DUAL-ENERGY CT IS A NEW

MANAGEMENT INDEX FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONHiroyuki Onishi*[1], Nakayama Kazuhiko[1], Yanaka Kenichi[1], Tamada Naoki[1], Izawa Yuu[1], Shinkura Yuto[1], Tuboi Yasunori[1], Shimoyama Shinsuke[3], Nishii Tatsuya[3], Kono Atushi[3], Negi Noriyuki[2], Mori Shumpei[1], Otake Hiromasa[1], Satomi-Kobayashi Seimi[1], Shinke Toshiro[1], Emoto Noriaki[4], Hirata Ken-Ichi[1]

[1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine ~ Kobe ~ Japan, [2]Division of Radiology, Center for Radiology and Radiation Oncology, Kobe University Hospital ~ Kobe ~ Japan, [3]

Department of Radiology, Kobe University Graduate School of Medicine ~ Kobe ~ Japan, [4]Department of Clinical Pharmacy, Kobe Pharmaceutical University ~ Kobe ~ Japan

C41 REPEATED EMBOLIZATION COMBINED WITH INHIBITION OF ANGIOGENESIS RESULTS IN EARLY CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN RABBITSRozenn Quarck*[1], Allard Wagenaar[1], Birger Tielemans[1], Frédéric Perros[3], Peter Dorfmüller[3], Catharina Belge[2], Marion Delcroix[2]

[1]KU Leuven ~ Leuven ~ Belgium, [2]University Hospitals Leuven ~ Leuven ~ Belgium, [3]

University Paris Sud ~ Le Plessis Robinson ~ France

C42 PREVALENCE AND CHARACTERISTICS OF PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION FROM A SINGLE SINGAPORE CENTREWen Ruan*[1], Kevin Quah[1], Jonathan Yap[1], Aidila Binte Ismail[1], Duu Wen Sewa[2], Ghee Chee Phua[2], Ai Leen Ang[2], Foong Koon Cheah[2], Kenny Loh[1], Chia Alicia Xue Fen[1], Choong Hee Lim[1], Jenkins David[3], Victor Tar Toong Chao[1], Soo Teik Lim[1], Ju Le Tan[1]

[1]National Heart Centre Singapore ~ Singapore ~ Singapore, [2]Singapore General Hospital ~ Singapore ~ Singapore, [3]Papworth Hospital NHS trust ~ London ~ United Kingdom

C43 SUBCUTANEOUS TREPROSTINIL FOR THE TREATMENT OF NON-OPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: A RANDOMIZED, CONTROLLED TRIAL (CTREPH)Roela Sadushi-Kolici*[4], Pavel Jansa[1], Grzegorz Kopec[2], Adam Torbicki[3], Ioana-Alexandra Campean[4], Gert Hoeffken[5], Nika Skoro-Sajer[4], Iveta Simkova[6], Kristof Karlocai[7], Regina Steringer-Mascherbauer[8], Miroslav Samarzija[9], Barbara Salobir[10], Walter Klepetko[11], Jaroslav Lindner[12], Irene Marthe Lang[4]

[1]Charles University of Prague, Cardiology ~ Prague ~ Czech Republic, [2]Department of Cardiac and Vascular Diseases Jagiellonian University Medical College Centre for Rare Cardiovascular Diseases John Paul II Hospital ~ Krakow ~ Poland, [3]John Paul II Hospital, Cardiac and Vascular Diseases Centre for Rare Cardiovascular Diseases ~ Warsaw ~ Poland, [4]Medical University of Vienna, Internal Medicine II, Cardiology ~ Vienna ~ Austria, [5]Internal Medicine I, Pulmonary Disease, University Carl Gustav Carus ~ Dresden ~ Germany, [6]Slovak Medical University, Cardiology ~ Bratislava ~ Slovakia, [7]

Semmelweis University Heart Center, Cardiology ~ Budapest ~ Hungary, [8]Elisabethinen University Teaching Hospital, Cardiology ~ Linz ~ Austria, [9]University Hospital Centre Zagreb, Respiratory Diseases ~ Zagreb ~ Croatia, [10]University Medical Centre of Ljubljana, Internal Medicine, Pulmonary Diseases and Allergy ~ Ljubljana ~ Slovenia, [11]

Medical University of Vienna, Thoracic Surgery ~ Vienna, Austria ~ Austria, [12]Charles University of Prague , Cardiovascular Surgery ~ Prague ~ Czech Republic

C44 THE ESC/ERS RISK ASSESSMENT INSTRUMENT FOR PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION IS ALSO APPLICABLE IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONAnna Sandqvist*[1], David Kylhammar[2], Barbro Kjellström[3], Stefan Söderberg[4]

[1]Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology, Umeå University ~ Umeå ~ Sweden, [2]Department of Clinical Physiology and Department of Medicine and Health Sciences, Linköping University ~ Linköping ~ Sweden, [3]Department of Medicine, Cardiology Unit, Karolinska Institute ~ Stockholm ~ Sweden, [4]Department of Public Health and Clinical Medicine, Heart Centre, Umeå University ~ Umeå ~ Sweden

C45 A TREATMENT GOAL TO IMPROVE RENAL FUNCTION AFTER BALLON PULMONARY ANGIOPLASTY IS REDUCING PULMONARY VSCULAR RESISTANCE IN PATIENTS WITH CHRONIC THROMBOLIC PULMONARY HYPERTENSIONIsobe Sarasa*, Itabashi Yuji, Kawakami Takeshi, Kataoka Masaharu, Murata Mitsushige, Fukuda KeiichiKeio uninversity ~ Tokyo ~ Japan



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POSTER SESSIONS

Thursday, March 1, 2018CTEPHC46 EARLY OUTCOMES FOLLOWING PULMONARY

ENDARTERECTOMY: AN AUSTRALIAN TERTIARY REFERRAL CENTRE EXPERIENCESarah Scheuer*[2], Sam Emmanuel[1], Anne Keogh[2], Joanna Pepke-Zaba[3], David Jenkins[4], David Boshell[1], Eugene Kotylar[5], Kumud Dhital[2]

[1]St Vincent’s Hospital ~ Sydney ~ Australia, [2]St Vincent’s Hospital; Victor Chang Cardiac Research Institute; University of New South Wales ~ Sydney ~ Australia, [3]

Papworth Hospital; Cambridge University ~ Cambridge ~ United Kingdom, [4]Papworth Hospital ~ Cambridge ~ United Kingdom, [5]St Vincent’s Hospital; University of New South Wales ~ Sydney ~ Australia

C47 PREDICTORS FOR WORSENING HEMODYNAMICS DURING FOLLOW-UP PERIOD AFTER BALLOON PULMONARY ANGIOPLASTYYuto Shinkura*[2], Kazuhiko Nakayama[2], Hiroyuki Onishi[2], Kenichi Yanaka[2], Naoki Tamada[2], Yasunori Tsuboi[2], Hiromasa Otake[2], Seimi Satomi-Kobayashi[2], Toshiro Shinke[2], Noriaki Emoto[1], Ken-Ichi Hirata[2]

[1]Department of Clinical Pharmacy, Kobe Pharmaceutical University, Japan ~ Kobe ~ Japan, [2]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine ~ Kobe ~ Japan

C48 A SIMPLE PREDICTIVE ALGORITHM FOR MORTALITY RISK IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONNika Skoro-Sajer*[1], Christian Gerges[1], Mario Gerges[1], Adelheid Panzenböck[1], Johannes Jakowitsch[1], Walter Klepetko[2], David Celermajer[3], Irene Lang[1]

[1]Cardiology, Medical University of Vienna ~ Vienna ~ Austria, [2]Department of Cardiothoracic Surgery ~ Vienna ~ Austria, [3]Sydney Medical School ~ Sydney ~ Australia

C49 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION MIMICS PULMONARY EMBOLISMAndris Skride*, Dana Kigitovica, Valdis Gibietis, Barbara Vitola, Sintija StrautmaneDr ~ Riga ~ Latvia

C50 SAFETY AND EFFICACY OF DIRECT ORAL ANTICOAGULANTS FOR PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN ONE EXPERT CENTER IN JAPANRika Suda*, Nobuhiro Tanabe, Takayuki Jujo, Akira Naito, Rintaro Nishimura, Toshihiko Sugiura, Seiichiro Sakao, Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan

C51 PULMONARY ENDARTERECTOMY AND BALLOON PULMONARY ANGIOPLASTY SIMILARLY IMPROVE HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION.Naoki Tamada*[1], Kazuhiko Nakayama[1], Ken-Ichi Yanaka[1], Hiroyuki Onishi[1], Yuto Shinkura[1], Kazuhiro P Izawa[2], Toshiro Shinke[1], Noriaki Emoto[3], Ken-Ichi Hirata[1]

[1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine ~ Kobe ~ Japan, [2]Graduate School of Health Sciences, Kobe University ~ Kobe ~ Japan, [3]Clinical Pharmacy, Kobe Pharmaceutical University ~ Kobe ~ Japan

C52 POOR SUBPLEURAL PERFUSION RELATING TO LESS DEVELOPED BRONCHIAL ARTERIES PREDICTS FAILURE AFTER BALLOON PULMONARY ANGIOPLASTY FOR NON-OPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONYu Taniguchi*[2], Philippe Brenot[1], Xavier Jais[2], Carlos Garcia[1], Olivier Planche[2], Elie Fadel[1], Marc Humbert[2], Gerald Simonneau[2]

[1]Hôpital Marie Lannelongue ~ PARIS ~ France, [2]Hôpital Universitaire de Bicêtre ~ PARIS ~ France

C53 THE WALL SHEAR STRESS OF THE PULMONARY ARTERIES IN THE PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION BEFORE AND AFTER BALLOON PULMONARY ANGIOPLASTY; ANALYSIS USING COMPUTATIONAL FLUID DYNAMICS.Hideo Tsubata*[1], Nakanishi Naohiko[1], Itatani Keiichi[2], Fukai Kuniyoshi[1], Yaku Hitoshi[2], Matoba Satoaki[1]

[1]Kyoto Prefectural University of Medicine ~ Kyoto ~ Japan, [2]Department of Cardiovascular Surgery, Kyoto Prefectural University of Medicine ~ Kyoto ~ Japan

C54 HYDATID EMBOLIZATION RELATED CHRONIC PULMONARY HYPERTENSIONOmac Tufekcioglu*[1], Idris Yakut[1], Yucel Kanal[1], Ilke Erbay[1], Funda Dereagzi[1], Yesim Akin[1], Levent Birincioglu[2], Hatice Sasmaz[1]

[1]Turkey Yuksek Ihtisas Hospital, Cardiology ~ Ankara ~ Turkey, [2]Turkey Yuksek Ihtisas Hospital, Cardiovascular Surgery ~ Ankara ~ Turkey



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POSTER SESSIONS

Thursday, March 1, 2018CTEPHC55 CASE SERIES OF SEVEN WOMEN WITH UTERINE FIBROIDS

LEADING TO THROMBOEMBOLIC DISEASE AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSIONAnjali Vaidya*[2], Anne-Sophie Lacharite-Roberge[1], Farhan Raza[2], Riyaz Bashir[2], Chandra Dass[4], Yoshiya Toyoda[3], Paul Forfia[2]

[1]Temple University Hospital Department of Medicine ~ Philadelphia ~ United States of America, [2]Temple University Hospital Heart and Vascular Institute ~ Philadelphia ~ United States of America, [3]Temple University Hospital Department of Cardiovascular Surgery ~ Philadelphia ~ United States of America, [4]Temple University Hospital Department of Radiology ~ Philadelphia ~ United States of America

C56 INITIAL CLINICAL AND HEMODYNAMIC RESULTS OF A REGIONAL PULMONARY THROMBOENDARTERECTOMY PROGRAMAnjali Vaidya*, Farhan Raza, Anne-Sophie Lacharite-Roberge, Chandra Dass, Riyaz Bashir, Toyoda Yoshiya, Paul ForfiaTemple Heart and Vascular Institute ~ Philadelphia ~ United States of America

C57 ENDOTHELIAL PROGENITOR CELLS (EPCS) IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH)Keiko Yamamoto*[2], Rintaro Nishimura[1], Akira Naito[2], Rika Suda[2], Takayuki Jujo[1], Seiichiro Sakao[2], Nobuhiro Tanabe[1], Koichiro Tatsumi[2]

[1]Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [2]Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan

C58 PREDICTIVE POWER OF THE RISK STRATIFICATION SCORES FOR PULMONARY HYPERTENSION IN PULMONARY EMBOLISM Yalin Tolga Yaylali*[1], Samet Yilmaz[1], Hande Senol[1], Omac Tufekcioglu[2]

[1]Pamukkale University ~ Kinikli, Denizli ~ Turkey, [2]Yuksek Ihtisas Training and Research Hospital ~ Ankara ~ Turkey

C59 PRACTICES SURROUNDING PULMONARY HYPERTENSION AND BRONCHOPULMONARY DYSPLASIA AMONGST NEONATOLOGISTS CARING FOR PREMATURE INFANTSGabriel Altit*, Henry Chong Lee, Susan Hintz, Theresa Tacy, Jeffrey Feinstein, Shazia BhombalStanford University ~ Palo Alto ~ United States of America

PEDIATRIC PHC60 PULMONARY ARTERY HYPERTENSION IS ASSOCIATED WITH

DECREASED CARDIAC OUTPUT IN FONTAN PATIENTS Vincent Aluquin*[1], Athira Nair[2], William Lee[3]

[1]Penn State Hershey Children’s Hospital ~ Hershey, Pennsylvania ~ United States of America, [2]UCSF Fresno ~ Fresno, California ~ United States of America, [3]Penn State University ~ State College, PA ~ United States of America

C61 INTRAVENOUS TREPROSTINIL AND OCCULT FRACTURES IN INFANTS: MORE THAN A CASUAL CORRELATION?Meghan Bernier*, Lewis RomerJohns Hopkins School of Medicine ~ Baltimore ~ United States of America

C62 THE CARDIOPULMONARY EXERCISE TESTING IN CHILDREN AND ADOLESCENTS WITH PULMONARY ARTERIAL HYPERTENSION.Mariana Cazalas*, Ines Abella, Alejandro Tocci, Claudio Moros, Maria Sicurello, Haydee Vazquez, Maria GrippoArgentine Society of Cardiology ~ Buenos Aires ~ Argentina

C63 PEDIATRIC PULMONARY HYPERTENSION AT CHIDREN HOSPITAL “DR RICARDO GUTIERREZ”BUENOS AIRES. ARGENTINAMariana Elisa Cazalas*, Maria Grippo, Ines Abella, Haydee Vazquez, Maria Sicurello, Alejandro Goldsman, Angela Sardella, Isabel TorresArgentine Society of Cardiology ~ Buenos Aires ~ Argentina

C64 PEDIATRIC PULMONARY HYPERTENSION AND CONGENITAL HEART DISEASE. EXPIERENCE AT CHILDREN HOSPITAL “DR. RICARDO GUTIÉRREZ” BUENOS AIRES, ARGENTINA.Mariana Elisa Cazalas*, Maria Grippo, Haydee Vazquez, Alejandro Goldsman, Maria Sicurello, Alberto Quilindro, Angela Sardella, Ines AbellaChildren Hospital Dr Ricardo Gutiérrez . Buenos Aires. Argentina ~ Buenos Aires ~ Argentina



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POSTER SESSIONS

Thursday, March 1, 2018PEDIATRIC PHC65 OUTCOMES OF TREATMENTS OF SELECTIVE PULMONARY

VASODILATORS AFTER THE TRANSCATHETER CLOSURE IN ATRIAL SEPTAL DEFECT WITH PULMONARY ARTERIAL HYPERTENSION Jae Young Choi*, Kim Jung Yoon, Kim Ah Young, Jung Jo Won, Jung Se YongDivision of Pediatirc Cardiology, Congenital Heart Disease Center, Severance Cardiovascular Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul ~ Seoul ~ Korea, Republic of

C66 COMPARISON BETWEEN PAEDIATRIC AND ADULT PATIENTS WITH PULMONARY ARTERIAL HYPERTENSIONFabio Dardi*, Alessandra Manes, Massimiliano Palazzini, Elisa Zuffa, Enrico Gotti, Andrea Rinaldi, Alessandra Albini, Enrico Monti, Daniele Guarino, Filippo Pasca, Nikita Tanese, Antonio Colangelo, Mariangela Rotunno, Andrea Donti, Nazzareno GalièUniversity of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

C67 ATRIAL SEPTAL DEFECT FENESTRATED DEVICES IN CHILDREN WITH SEVERE PULMONARY HYPERTENSIONAnne Fournier*, Francisco Gonzales-Barlatay, Maire-Josee Raboisson, Julie Briere, Nagib DahdahCHU mere-enfant Sainte-Justine ~ Montreal ~ Canada

C68 EPIDEMIOLOGICAL CHARACTERISTICS OF PULMONARY ARTERIAL HYPERTENSION IN THE PEDIATRIC POPULATION. REGISTRATION OF A MEXICAN NATIONAL CENTER.Humberto Garcia*, Emilia Covian, Sandra Patricia Antunez, Eduardo Melendez, Ramon Flores, Antonio SalgadoISSSTE ~ Mexico ~ Mexico

C69 ECONOMIC EVALUATION AND BUDGET IMPACT ANALYSIS OF A PEDIATRIC PULMONARY HYPERTENSION PROGRAM IN MEXICO. Humberto Garcia*[1], Silvia Guzman[2], Enrique Gomez Alvarez[3], Maria Emilia Covian[3], Araceli Olivares[2], Herman Soto[2]

[1]ISSSTE ~ Mexico ~ Mexico, [2]HS ~ Mexico ~ Mexico, [3]~ Mexico ~ Mexico

C70 VENTRICULAR ARTERIAL COUPLING RATIO AND VOLUMES CORRELATE WITH RIGHT VENTRICULAR STRAIN AND PREDICTS OUTCOMES USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY IN PEDIATRIC PULMONARY HYPERTENSIONPei-Ni Jone*, Michal Schäfer, Dunbar IvyChildren’s Hospital Colorado, University of Colorado School of Medicine ~ Aurora ~ United States of America

C71 COMPARATIVE ANALYSIS OF DETERMINING RISK FACTORS OF PNEUMOTHORAX COMPLICATING PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN IN THAI NEONATES Narongsak Nakwan*, Sutthikiat Jaroensri, Wuttichart KamolvisitDepartment of Pediatrics, Hat Yai Hospital ~ Songklha ~ Thailand

C72 A CASE OF ATRIAL SEPTAL DEFECT ASSOCIATED PULMONARY ARTERIAL HYPERTENSION RELATED TO EISENMENGER’S SYNDROMEHidemi Sorimachi*, Noriaki Takama, Masahiko KurabayashiDepartment of Cardiovascular Medicine, Gunma University Graduate School of Medicine ~ Maebashi ~ Japan

C73 FIRST-IN-CHILD USE OF THE SOLUBLE GUANYLATE CYCLASE STIMULATOR RIOCIGUAT IN PULMONARY ARTERIAL HYPERTENSIONTill Spreemann*, Christoph Happel, Harald Bertram, Georg HansmannHannover Medical School ~ Hannover ~ Germany

C74 IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION IN PEDIATRICS: VALIDITY OF DOPPLER COLOR ECHOCARDIOGRAM FOR THE NON-INVASIVE DIAGNOSISCarolina Stepffer*, Adelia Marques, Julieta Rancati, Ines Martinez, Jesus Damsky Barbosahospital elizalde ~ buenos aires ~ Argentina

C75 CONGENITAL HEART DEFECT WITH PULMONARY HYPERTENSION: IS POSSIBLE A SURGICAL CORRECTION AFTER TREATMENT WITH SILDENAFIL?Carolina Stepffer*, Maria Adelia Marques, Ines Martinez, Ana De Dios, Jesus Damsky Barbosahospital elizalde ~ buenos aires ~ Argentina



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POSTER SESSIONS

Thursday, March 1, 2018PATIENTS’ PERSPECTIVESC76 PHARMACOECONOMIC BURDEN OF PULMONARY

HYPERTENSION IN DIFFERENT HEALTH CARE SYSTEMSCharles Burger D.*, Mohamedanwar Ghandour, Divya Padmanabhan MenonMayo Clinic ~ Jacksonville, Florida ~ United States of America

C77 INTERNATIONAL ENVIRONMENTAL SCAN OF SPECIALIZED PULMONARY HYPERTENSION CLINICS Carolyn Doyle-Cox*[1], Gail Nicholson[2], Wendy Gin-Sing[3], Traci Stewart[4]

[1]University of Ottawa Heart Institue ~ Ottawa ~ Canada, [2]Alberta Health Services ~ Alberta ~ Canada, [3]Hammersmith Hospital ~ London ~ United Kingdom, [4]University of Iowa ~ Iowa ~ United States of America

C78 ORAL UPFRONT COMBINATION THERAPY IN PATIENTS WITH CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION: FROM A RETROSPECTIVE COHORT STUDYKentaro Ejiri*, Satoshi Akagi, Toshihiro Sarashina, Kazufumi Nakamura, Hiroshi ItoOkayama University ~ Okayama ~ Japan

C79 ASSESSMENT OF LUNG ULTRASONOGRAPHY AS PREDICTOR OF PULMONARY INVOLVEMENT IN A COHORT OF PATIENTS AFFECTED BY SYSTEMIC SCLEROSIS COMPLICATED BY EITHER INTERSTITIAL LUNG DISEASE OR PULMONARY ARTERIAL HYPERTENSIONElisa Tinazzi*, Federico Confente, Gloria Tacchella, Giuseppe Patuzzo, Claudio LunardiUniversity of Verona ~ Verona ~ Italy



50

GENERAL INFORMATIONCONGRESS LOCATIONNice Acropolis Congress CenterEntrance for the public from Risso Boulevard, NicePh: +33 (0)4 93 92 83 00Fax: +33 (0)4 93 92 82 55

OFFICIAL LANGUAGEThe official language of the Symposium is English.

SECURITY CHECKPOINTFor safety reasons, every person accessing to the Nice Acropolis Congress Center has to go through a Security Checkpoint placed at the entrance. We suggest to all participants to arrive in due time.

REGISTRATIONEvery registered attendee can collect his/her congress kit at the Registration Desk placed in Agora 1 after the main entrance. New Registrations are accepted onsite only with payment by credit/debit card.

REGISTRATION FEES (VAT INCLUDED)Registration Fee Poster presenters € 550,00University & public/private hospital nurses* € 550,00University & public/private hospital physicians* € 1.200,00No-university/no-public/no-private hospital physicians and pharma companies representatives € 3.300,00

Reduced fee for staff members of the sponsor companies € 1.650,00

* To benefit from this Registration Fee, the participant must provide the Organizing Secretariat with a document testifying his/her affiliation to the University/Hospital.

The Registration Fee includes:Admission to Scientific Sessions, congress kit, coffee breaks and lunches.Accompanying persons are not accepted in the Congress Area.

BADGESParticipants are requested to wear their congress badge during allsessions, coffee breaks, lunches.Badges colored stripes:RED: TASK FORCES BLUE: ATTENDEESYELLOW: SPONSORSGREY: ORGANIZATION STAFF

REGISTRATION AND POSTER DESKThe desks are open during the congress as follows:Monday February 26 from 16.00 to 19.00Tuesday February 27 from 07.30 to 19.00Wednesday February 28 from 08.00 to 17.30Thursday March 1 from 08.00 to 17.30

INTERNET CONNECTIONAll the congress venue is WIFI area – codes to access internet are:• WIFI name: wsph2018• login: wsph2018• password: wsph2018

VOTING SYSTEMThrough a WEBAPP the audience is kindly requested to attend the interactive part of each TF session. Instructions are given onsite.The use of the voting system is reserved to PHYSICIANS employed in Universities or Hospitals (no pharmaceutical companies staff); the Organizing Secretariat invites any participant to comply with this guideline.

COFFEE BREAKS AND LUNCHESCoffee breaks are arranged in Agora 2, outside the Meeting Hall.Lunches are served in Agora 3, while desserts and coffees in Agora 2, next to the Posters Area.No accompanying person is allowed to access coffee breaks and lunches during the Conference.

BARMykonos Bar is open during the Conference at Acropolis Center (drinks upon payment).

CERTIFICATE OF ATTENDANCEThe certificate of attendance is available on request at the Registration Desk.

ABSTRACT BOOKThe Posters Abstract Book is published on the Symposium Website: www.wsph2018.com



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GENERAL INFORMATIONINFORMATION FOR SPEAKERS, POSTER PRESENTERS AND AWARDED BEST POSTERS

SPEAKERS: Slide center opening timesMonday February 26 from 16.00 to 19.00Tuesday February 27 from 07.30 to 19.00Wednesday February 28 from 08.00 to 17.30Thursday March 1 from 08.00 to 17.30

Speakers are kindly requested to reach our technical support team in the slide center not later than 2 hours before the relevant scheduled session in order to copy the presentations onto the meeting computer.Presentations must be in Power Point and no personal computer is allowed.The operating system is Microsoft Windows Office and converter for Macintosh is available.If the speech is at 9.00 in the morning, the speaker is kindly invited to deliver his/her slides the day before.

POSTER PRESENTERS: Mounting and dismounting rulesTouch screens are available in the Posters Area to find any poster and author name.The number of the corresponding panel (where the poster must be fixed) is indicated near each name. In the Posters Area, presenters can find the necessary material to hang their posters.Our staff is in assistance to the presenters to fix their posters in the Posters Area (Agora 2).

Mounting Time:Any presenter must fix his/her poster/s on the assigned day from 08.00 to 09.00.For presentations on February 27, poster mounting is allowed from 7.30 to 9.00 and also the day before February 26 from 16.00 to 19.00.

Dismounting Time:Any presenter is requested to dismount his/her poster/s at the end of the day of exhibition within 19.30.At 19.30 of the same day, our Organization will remove and eliminate all posters not dismounted.

POSTER PRESENTATIONAlthough no poster discussion is planned, the poster presenters are kindly invited to be near their posters during lunch time in order to assist attendees interested in having information on their works.

BESTS POSTER AWARDS CEREMONYAll winners are kindly requested to be present in Apollon hall on February 27 at 12.30 for the Best Poster Awards Ceremony.

EACCME CREDITSThe 6TH WORLD SYMPOSIUM ON PULMONARY HYPERTENSION, Nice, France, 27/02/2018-01/03/2018 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 19 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 Credits ™. Information on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities. Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.

EACCME® creditsEach participant can only receive the number of credits he/she is entitled to, according to his/her actual participation at the event once he/she has completed the feedback form. Cf. criteria 9 and 23 of UEMS 2016.20.In order to help you issue individual certificates to each participants, please find below the breakdown of ECMEC®s per day:27.02.2018 - 7,0028.02.2018 - 6,0001.03.2018 - 6,00

The EACCME® awards ECMEC®s on the basis of 1 ECMEC® for one hour of CME with a maximum of 8 ECMEC®s per day. Cf. Chapter X of UEMS 2016.20.



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GENERAL INFORMATIONTRANSPORTATIONAccess to Nice Acropolis Congress Center

From the airport:Take Bus n° 98 to the station ”cathédrale vieille-ville”; then take the tramway towards “Hôpital Pasteur”; Stop at “Acropolis”.

From the train station:Take the tramway towards “Hôpital Pasteur”; Stop at “Acropolis”.

From the A8 motorway “Provencal”:Exit n° 50 towards “Nice Centre“ and the “Promenade des Anglais“; then follow the directions for “Acropolis“.

NICE TRAMWAYNice inaugurated the first line of its tramway (T1) on November 24, 2007. The line runs for 8.7 km and stretches from the northern tip of Nice, Nice-Nord (Boulevard Comte de Falicon) near the Ray Stadium and the A8 motorway, all the way to “Hôpital Pasteur”.Name of the tramway stop for the congress: ACROPOLIS.Due to Carnival Parades to be held on some days of the Symposium, the tram circulation could be redirected.For further information:http://en.nicecarnaval.com/access-transport-and-parking

PRIVACY POLICY AND DIFFUSION OF THE IMAGESPursuant to art. 13 of Legislative Decree no. 196/2003, the personal data of the participants, the video footage and the photographs taken at the World Symposium on Pulmonary Hypertension will be processed by I & C S.r.l. exclusively for purposes related to the communication and enhancement of this event. The provision of personal data is optional, but any refusal to provide such data will not allow you to participate in video and photo shoots.

The processing will be carried out thanks to adequate tools to guarantee security and privacy and can be carried out also through automatic tools that will memorize, manage and transmit the data.Images will be sent, communicated, shown only to third parts appointed to carrying out the necessary activities for the purposes mentioned above and will eventually be publicized through publications on the event website for the strict necessary time to carry out the purposes of the processing.The Data Controller is I & C s.r.l., located in Bologna, Via Andrea Costa, 202/6 phone +39 051 6144004, fax +39 051 6142772, email address [email protected] In relation to the data provided, each participant may exercise the rights referred to art. 7 of Legislative Decree no. 196/2003,

by contacting the Data Controller at the addresses indicated above.

USEFUL AND EMERGENCY NUMBERSTAXI: Tel.: +33(0)4 93 13 78 78AIRPORT: Tel: +33 820 42 33 33AMBULANCE: 15POLICE: 17FIREFIGHTERS: 18

PALAIS DES CONGRÈS ACCESS PLAN

Tram line Line 1 route "Acropolis" & "Palais des Expositions" stops

rail stationSNCF

ACROPOLIS

PORT Nice Côte d'Azur

MEDITERRANEAN SEA

Nice Côte d'Azur

Exit 55

Nice Est

A8

A8

To

ITALy

Bd Cessole

Bd de Cimiez

Vieux Nice

Bd Gam

betta

Voie PierreM

athi

s

(Expressway)

Av. Jean Médecin

Nice Côte

d'Azur

AiRPORT

Promenade des Anglais

To

CANNESTo

MONACO

Nicecastle

Av. Desambrois

Av. Borriglione

Tunnel André Malraux Av. des Diables Bleus

Route de Turin

Quai desEtats-Unis

Albert 1er

gardens

Pl. Garibaldi

Pl. Masséna

Bd Jean Jaurès

Bd R

isso

Bd d

e Riq

uier

Bd S

t-Roc

h

Bd P

aste

ur

Rue

A. G

al

Av. Félix

Av. Thiers

Bd Victor Hugo

Rue de France

Faur

e

Bd. J

B Ve

rany

Rout

e de

Turin

Bd. du Gal. Delfino

Bd. R

isso

Rue Barla

TO THE PORT

Av. d

e la

Rép

ubliq

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Av. G

allié

ni

Bd. SolaVoieRapide

Parc autoVinci Park

2 000 places

EsplanadeMal. de Lattrede Tassigny

ACROPOLISPALAIS DES CONGRÈS

Av. M

al. L

yaut

ey

Palais des CongrèsDelivery area

AuvarePark

Main entrance



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AUTHORS AND TASK FORCES MEMBERS INDEX

Abe Kohtaro .............................................................................................................................................................................22Abella Ines .................................................................................................................................................................................47Abman Steven ........................................................................................................................................................................12Acar Serap .................................................................................................................................................................................31Adachi Shiro .............................................................................................................................................................................42Adams John ....................................................................................................................................................................36, 37Adatia Ian T. K. ........................................................................................................................................................................12Aguirre-Zurita Oscar ..........................................................................................................................................................40Ah Young Kim .........................................................................................................................................................................48Ahsan Fakhrul .........................................................................................................................................................................15Akagi Satoshi ..................................................................................................................................................................15, 49Akdeniz Bahri .................................................................................................................................................................29, 31Akdogan Ali .............................................................................................................................................................................25Akgun Alperen Emre ........................................................................................................................................................42Akihiro Honda ........................................................................................................................................................................36Akin Yesim .................................................................................................................................................................................46Akritidou Sofia .......................................................................................................................................................................34Al Hilal Taslim A .....................................................................................................................................................................15Al-Mamun Elias .............................................................................................................................................................25, 39Al-Mamun Mohammad Elias .....................................................................................................................................41Alarco Walter ...........................................................................................................................................................................40Albanese Patricia ..................................................................................................................................................................15Albiach-Montañana Cristina .......................................................................................................................................41Albini Alessandra ........................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Aldred Micheala ............................................................................................................................................................. 8, 21Alexandra Arvanitaki .........................................................................................................................................................27Alice Huertas ..................................................................................................................................................................15, 18Alicia Xue Fen Chia .............................................................................................................................................................45Alonso-Gonzalez Rafael .................................................................................................................................................26Altit Gabriel .............................................................................................................................................................22, 28, 47Aluquin Vincent .....................................................................................................................................................................47Aman Jurjan .............................................................................................................................................................................18Amélie Cumont .....................................................................................................................................................................18Amissi Said ................................................................................................................................................................................22Ammirati Enrico ....................................................................................................................................................................40Anderson Stephanie .........................................................................................................................................................39Andreas Rieth..........................................................................................................................................................................43Andrew Ruth ............................................................................................................................................................................16Andrijevic Ana ........................................................................................................................................................................29Andrijevic Ilija ..........................................................................................................................................................................29Anegon Igniacio ...................................................................................................................................................................16Ang Ai Leen .....................................................................................................................................................................43, 45Anggrahini Dyah Wulan ...............................................................................................................................25, 26, 33Anneliese Larose ..................................................................................................................................................................39Anthi Anastasia ..................................................................................................................................26, 27, 31, 35, 36

Antigny Fabrice .................................................................................................................................15, 16, 18, 22, 23Antunez Sandra Patricia ..................................................................................................................................................48Aonuma Kazutaka ......................................................................................................................................................17, 18Apostolopoulou Olympia ....................................................................................................................................31, 36Aranda Alvaro .........................................................................................................................................................................39Armagan Berkan ..................................................................................................................................................................25Armaganidis Apostolos .......................................................................................................................19, 31, 35, 36Armstrong Iain........................................................................................................................................................................12Asano Ryotaro ........................................................................................................................................................................44Asano Yoshihiro .....................................................................................................................................................................40Asil Serkan .................................................................................................................................................................................25Atahan Ersan ...........................................................................................................................................................................44Atamañuk Nicolas ...............................................................................................................................................................34Atas Halil .....................................................................................................................................................................................29Athanasopoulos Georgios ..................................................................................................................................26, 27Atsuko Tahara .........................................................................................................................................................................36Atsumi Tatsuya ..............................................................................................................................................................29, 35Atushi Kono ..............................................................................................................................................................................45Aueyingsak Sahachat .......................................................................................................................................................25Auger Cyril ................................................................................................................................................................................22Auger William .........................................................................................................................................................................13Austin Eric ..................................................................................................................................................................................20Avgeropoulou Ekaterini ........................................................................................................................................26, 27Ayumi Sekine ..........................................................................................................................................................................15Bacharova Ljuba ...................................................................................................................................................................25Badagliacca Roberto.........................................................................................................................................................24Badesch David B. ........................................................................................................................................................... 9, 20Badlam Jessica ......................................................................................................................................................................20Bagalas Vasileios ..................................................................................................................................................................34Bailly Sabine .............................................................................................................................................................................19Baird Grayson .........................................................................................................................................................................19Baldus Stephan ..........................................................................................................................................31, 33, 38, 40Balint Olga Hajnalka ..........................................................................................................................................................35Bang Oh Young .....................................................................................................................................................................28Barbera Joan A ......................................................................................................................................................................17Barberà Joan Albert................................................................................................................................11, 13, 32, 38Baris Nezihi ...............................................................................................................................................................................31Barnes Hayley ................................................................................................................................................................40, 42Barr R Graham .......................................................................................................................................................................19Barreira Bianca .......................................................................................................................................................................17Bartfay Sven-Erik...................................................................................................................................................................26Barth Angeles .........................................................................................................................................................................23Bashir Riyaz ...............................................................................................................................................................................47Batool Mahreen ....................................................................................................................................................................19Bauer Uta-Maria ....................................................................................................................................................................20



54


Baumgartner Helmut ........................................................................................................................................................35Bazmpani Maria Anna ......................................................................................................................................................27Beghetti Maurice ..................................................................................................................................................................12Behr Jürgen ..............................................................................................................................................................................37Belchi Joaquina .....................................................................................................................................................................41Belevskaya Anna ..................................................................................................................................................................35Belge Catharina...................................................................................................................................................18, 19, 45Belhaj Asmae ..........................................................................................................................................................................23Benas Dimitris .........................................................................................................................................................................36Bengus Monica ......................................................................................................................................................................37Benjamin Nicola .........................................................................................................................................14, 20, 29, 39Benza Ray ...................................................................................................................................................................................20Benza Raymond L. ..............................................................................................................................................................10Bergen Ingrid ..........................................................................................................................................................................23Berger Rolf M.F. .....................................................................................................................................................................12Berghausen Eva ....................................................................................................................................................................19Berjaoui Wael ..........................................................................................................................................................................42Berman Rosenzweig Erika ............................................................................................................................................12Bernier Meghan ...........................................................................................................................................................15, 47Bertoletti Laurent ..................................................................................................................................................................44Bertram Harald.......................................................................................................................................................................48Best Hunter ...............................................................................................................................................................................43Bhatta Anil ..................................................................................................................................................................................15Bhombal Shazia ..................................................................................................................................................22, 28, 47Bigorgne Amélie ..................................................................................................................................................................18Bilge Ahmet Kaya .......................................................................................................................................................30, 35Bingol Zuleyha .......................................................................................................................................................................30Birincioglu Levent ................................................................................................................................................................46Birkfellner Wolfgang .........................................................................................................................................................43Bischoff Florian ......................................................................................................................................................................19Blackwater Tyler ....................................................................................................................................................................24Blanco Isabel ...........................................................................................................................................................................38Blank Norbert..........................................................................................................................................................................14Bleda Marta .....................................................................................................................................................................13, 21Blenkhorn Fay .........................................................................................................................................................................24Bloch Konrad E ......................................................................................................................................................................16Bluemke David ......................................................................................................................................................................19Bobas Georgios ....................................................................................................................................................................44Boeckel Jes-Niels .................................................................................................................................................................19Boehm Nelly ............................................................................................................................................................................22Boet Angele ....................................................................................................................................................................16, 23Bogaard Harm Jan ...................................................................................................................................13, 15, 17, 21Bohacekova Marcela.......................................................................................................................................25, 42, 44Bohgaki Toshiyuki .......................................................................................................................................................29, 35Böhm Mario..............................................................................................................................................................................24

Bondue Antoine...........................................................................................................................................................24, 40Bonnet Damien ............................................................................................................................................................12, 21Bonnet Dominique .............................................................................................................................................................15Bonnet Sebastien.....................................................................................................................................................................8Boomars Karin ........................................................................................................................................................................23Boonstra Anco ........................................................................................................................................................................32Bordenave Jennifer ...................................................................................................................................................15, 19Bortman Guillermo .............................................................................................................................................................34Boshell David ..........................................................................................................................................................................46Bossone Eduardo .......................................................................................................................................................14, 38Boucly Athénaïs ............................................................................................................................................................31, 42Bourdin Arnaud .....................................................................................................................................................................21Boutou Afroditi ......................................................................................................................................................................34Bouzina Habib ...............................................................................................................................................................28, 30Breijer Fabian ..........................................................................................................................................................................18Brenot Philippe ......................................................................................................................................................................46Briere Julie .................................................................................................................................................................................48Brili Styliani ................................................................................................................................................................................31Brimioulle Serge ...................................................................................................................................................................23Brown Lynette .........................................................................................................................................................................43Brown Zoe ........................................................................................................................................................................40, 42Bru-Mercier Gilles ................................................................................................................................................................16Brunner Nathan W ..............................................................................................................................................................41Bruschi Eleonora ..................................................................................................................................................................25Buendia-Fuentes Francisco ..........................................................................................................................................35Burban Mélanie .....................................................................................................................................................................22Burgel Pierre-Regis .............................................................................................................................................................42Burns Andrew ................................................................................................................................................................40, 42Busse Dennis ...........................................................................................................................................................................33Butane Lina ...............................................................................................................................................................................38Byun Kyunghee ...................................................................................................................................................15, 20, 39Cai Zongye ..............................................................................................................................................................15, 23, 25Caillat-Zucman Sophie ....................................................................................................................................................13Campean Ioana-Alexandra..........................................................................................................................................45Cannon John ...........................................................................................................................................................................13Canuet Mathieu .....................................................................................................................................................................22Cao Aiqin ....................................................................................................................................................................................17Capuano Véronique ..........................................................................................................................................................23Caravita Sergio ..............................................................................................................................................................24, 40Cardenas-Tealdo Juan Pablo ......................................................................................................................................41Carole Phan .....................................................................................................................................................................15, 18Carolino D’Araujo Sandy ...............................................................................................................................................40Caruso Nicolas .......................................................................................................................................................................34Casado-Arroyo Rubén .....................................................................................................................................................34Castan Agnès ..........................................................................................................................................................................19



55


Catravas John .........................................................................................................................................................................24Cazalas Mariana Elisa .......................................................................................................................................................47Celermajer David S. ........................................................................................................9, 23, 30, 35, 40, 41, 46Cetinarslan Ozge .................................................................................................................................................................26Ceyhan Berrin .........................................................................................................................................................................29Cha Jihoon ................................................................................................................................................................................28Chakinala Murali ...................................................................................................................................................................38Chamorro-Fernández Carlos Israel .......................................................................................................................35Chang Hao-Chih ...................................................................................................................................................................23Chang Hsiang-Yuan............................................................................................................................................................29Chang Hyuk Jae ...........................................................................................................................................................33, 38Chang Sung-A ...............................................................................................................................................................28, 38Chang Wei-Ting.....................................................................................................................................................................29Channick Richard N. .................................................................................................................................................10, 24Chantepie Sandrine ...........................................................................................................................................................15Chao Victor Tar Toong .............................................................................................................................................43, 45Chaouat Ari ...............................................................................................................................................................................21Charles D Burger ..................................................................................................................................................................49Chassagnon Guillaume ..................................................................................................................................................42Chazova Irina .........................................................................................................................................................11, 35, 36Cheah Foong Koon ...................................................................................................................................................43, 45Chelabi Samy ..........................................................................................................................................................................42Chelladurai Prakash ..................................................................................................................................................16, 20Chen Frederick Y ..................................................................................................................................................................23Chen I-Chen .............................................................................................................................................................................40Chen Pin-I ...................................................................................................................................................................................17Chen Wei ....................................................................................................................................................................................19Chew Benjamin ............................................................................................................................................................26, 28Chia Alicia Xue Fen .............................................................................................................................................................43Chih-Hsin Hsu .........................................................................................................................................................................30Chin Kelly Marie .............................................................................................................................................................. 9, 38Cho Jae Yeong .......................................................................................................................................................................44Cho Myeong-Chan .............................................................................................................................................................40Cho Young Seok ...................................................................................................................................................................28Choi Hanul ...............................................................................................................................................................15, 20, 39Choi Jae Young ...................................................................................................................................................33, 38, 48Choi Jung Hyun ....................................................................................................................................................................34Choi Seungbum ..................................................................................................................................................15, 20, 39Chomette Laura ....................................................................................................................................................................40Chong Lee Henry .................................................................................................................................................................47Christophe Guignabert ..........................................................................................................................................15, 18Chung Kevin ..........................................................................................................................................................15, 30, 41Chung Wendy Kay ........................................................................................................................................................ 8, 20Chung Wook-Jin ..........................................................................................................................................................20, 39Church Colin ............................................................................................................................................................................21

Cipriani Manlio Gianni .....................................................................................................................................................40Cittadini Antonio .........................................................................................................................................................14, 38Clapp Lucie H ..........................................................................................................................................................................37Codde Jim ........................................................................................................................................................................30, 41Coghlan Gerry ......................................................................................................................................................13, 21, 29Coghlan John .........................................................................................................................................................................11Cogolludo Angel .................................................................................................................................................................17Cohen-Kaminsky Sylvia ........................................................................................................................13, 15, 16, 30Colangelo Antonio .............................................................................................31, 34, 35, 37, 41, 42, 43, 48Cole Michele ............................................................................................................................................................................34Colvin Johanna ......................................................................................................................................................................38Condliffe Robin ......................................................................................................................................................................21Confente Federico ..............................................................................................................................................................49Coronel Maria Lorena.......................................................................................................................................................34Corris Paul A. ..........................................................................................................................................................10, 13, 21Corso Pereira Mônica .......................................................................................................................................................28Cottin Vincent..........................................................................................................................................................................21Courboulin Audrey ....................................................................................................................................................15, 16Courtier Anais .........................................................................................................................................................................13Covian Emilia ...........................................................................................................................................................................48Covian Maria Emilia ...........................................................................................................................................................48Crippa Diego ...........................................................................................................................................................................23Cristos Feloukidis .................................................................................................................................................................27D’’Angelo Luciana ......................................................................................................................................................25, 40Dabral Swati ....................................................................................................................................................................16, 24Dahdah Nagib ........................................................................................................................................................................48Dai Zen-Kong ..........................................................................................................................................................................40Dai-Yin Lu ....................................................................................................................................................................................23Damico Rachel .......................................................................................................................................................................14Dammann Reinhard ..........................................................................................................................................................16Damsky Barbosa Jesus ...................................................................................................................................................48Danesino Cesare ..................................................................................................................................................................21Dardi Fabio ......................................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Dartevelle Philippe .............................................................................................................................................................15Daru Victor ........................................................................................................................................................................23, 29Das Tridib ....................................................................................................................................................................................23Dass Chandra ..........................................................................................................................................................................47Daugherty Louise C ...........................................................................................................................................................21David Jenkins ..........................................................................................................................................................................45David Montani ........................................................................................................................................................................39Davies Rachel ..........................................................................................................................................................................32De Dios Ana .............................................................................................................................................................................48De Marco Teresa ...................................................................................................................................................................11De Montpréville Vincent Thomas ...........................................................................................................................17De Perrot Marc .......................................................................................................................................................................10



56


De Raaf Michiel......................................................................................................................................................................23Dean Afshan.............................................................................................................................................................................23Delavenne Xavier ................................................................................................................................................................44Delcroix Marion ..............................................................................................................12, 13, 18, 19, 32, 38, 45Demerouti Eftihia ........................................................................................................................................................26, 27Demir Rengin ..........................................................................................................................................................................26Demolli Shemsi .....................................................................................................................................................................19Denis Migdalia .......................................................................................................................................................................12Denton Christopher P ................................................................................................................................................ 9, 29Denver Nina .............................................................................................................................................................................16Dereagzi Funda .....................................................................................................................................................................46Detterich Jon ...........................................................................................................................................................................19Dewachter Céline .......................................................................................................................................................23, 40Dewachter Laurence ................................................................................................................................................23, 24Dhital Kumud ..........................................................................................................................................................................46Diab Nermin ............................................................................................................................................................................14Dillberger John ......................................................................................................................................................................39Dimitris Benas .........................................................................................................................................................................36Dimitrova Elena .....................................................................................................................................................................31Dimmeler Stefanie ..............................................................................................................................................................19Dimopoulos Konstantinos ............................................................................................................................................26Dinarti Lucia Kris .................................................................................................................................................25, 26, 33Distler Oliver ............................................................................................................................................................................29Docherty Craig ..............................................................................................................................................................16, 23Dodson Mark ..........................................................................................................................................................................43Doelberg Martin ...................................................................................................................................................................29Donti Andrea ...........................................................................................................................................................................48Dorfmüller Peter ................................................................................................................8, 13, 15, 16, 17, 30, 45Doundoulakis Ioannis ......................................................................................................................................................27Doyle-Cox Carolyn ..............................................................................................................................................................49Drake William ..........................................................................................................................................................................34Droma Yunden .......................................................................................................................................................................22Dromer Claire .........................................................................................................................................................................21Dumas Sébastien J ...........................................................................................................................................13, 15, 16Dumitrescu Daniel ...................................................................................................................................31, 33, 38, 40Duncker Dirk Jan ................................................................................................................................................15, 23, 25Dunning John .........................................................................................................................................................................13Durmus Nedim ......................................................................................................................................................................16Durmus Sinan..........................................................................................................................................................................42Egenlauf Benjamin ....................................................................................................................................................14, 39Eichstaedt Christina A. ..........................................................................................................................14, 16, 20, 38Einarsson Gunnar ................................................................................................................................................................16Eita Kumagai............................................................................................................................................................................36Ejiri Kentaro ..............................................................................................................................................................................49El-Gazayerly Amany N. ....................................................................................................................................................10

El-Nikhely Nefertiti ..............................................................................................................................................................18Elding Heather .......................................................................................................................................................................13Elias-Al-Mamun Mohammad .....................................................................................................................................17Elliott Gregory .........................................................................................................................................................8, 20, 43Emmanuel Sam .....................................................................................................................................................................46Emoto Noriaki ......................................................................................................................................................14, 28, 46Endo Jin .......................................................................................................................................................................................24Epis Oscar Massimiliano ................................................................................................................................................25Erbay Ilke ....................................................................................................................................................................................46Erden Abdulsamet ..............................................................................................................................................................25Erdogan Okan ........................................................................................................................................................................29Escribano-Subias Pilar .............................................................................................................................................32, 36Evyapan Fatma.......................................................................................................................................................................42Ewert Ralf ....................................................................................................................................................................................39Eyries Mélanie ........................................................................................................................................................................21Fabregat-Andrés Oscar ..................................................................................................................................................41Fabrice Antigny .....................................................................................................................................................................17Fadel Elie .............................................................................................................................10, 15, 16, 17, 23, 30, 46Faini Andrea .............................................................................................................................................................................40Faoro Vitalie ..............................................................................................................................................................................24Farber Harrison ...........................................................................................................................................20, 27, 36, 38Farina Juan ..............................................................................................................................................................23, 29, 34Farré Marti Richard .............................................................................................................................................................19Feige Jean-Jacques ...........................................................................................................................................................19Feinstein Jeffrey ..................................................................................................................................................22, 28, 47Feldkircher Kathy .................................................................................................................................................................20Feloukidis Christos ..............................................................................................................................................................31Ferrando Monica ..................................................................................................................................................................41Ferrari Pisana ...........................................................................................................................................................................12Fesler Pierre .....................................................................................................................................................................23, 40Fiehn Christoph .....................................................................................................................................................................14Filipe-Santo Orchidee ......................................................................................................................................................13Fine Nowell ...............................................................................................................................................................................33Fink Ludger ......................................................................................................................................................................18, 43Finkov Bozhidar.....................................................................................................................................................................31Firat Esra ......................................................................................................................................................................................25Fischer Christine .................................................................................................................................................14, 20, 29Florence Parent ......................................................................................................................................................................39Flores Ramon ..........................................................................................................................................................................48Foderaro Andrew .................................................................................................................................................................19Forfia Paul ...................................................................................................................................................................................47Forsythe Clint ..........................................................................................................................................................................39Forton Kevin .............................................................................................................................................................................24Fournier Anne .........................................................................................................................................................................48Franco Veronica .....................................................................................................................................................................32



57


Frantz Robert P. ......................................................................................................................................................................10Frantzeskaki Frantzeska ................................................................................................................................19, 31, 35Frey Maria ..................................................................................................................................................................................43Frigerio Maria .................................................................................................................................................................25, 40Fritz Jason ..................................................................................................................................................................................19Frogoudaki Alexandra .....................................................................................................................................................31Frossard Nelly .........................................................................................................................................................................15Frost Adaani ....................................................................................................................................................................... 9, 20Fujieda Yuichiro .....................................................................................................................................................................29Fukiko Ichida ............................................................................................................................................................................14Fukuda Keiichi ...............................................................................................................................................................24, 44Fukui Shigefumi ....................................................................................................................................................................44Fumitaka Tajima ...........................................................................................................................................................28, 42Furukawa Asuka ...........................................................................................................................................................28, 32Gabriel Harald ........................................................................................................................................................................35Gaine Sean P. ..................................................................................................................................................................11, 38Galiè Nazzareno .........................................................8, 10, 12, 31, 34, 35, 37, 40, 41, 42, 43, 44, 48Gall Henning ..........................................................................................................................................................18, 21, 32Galvez David ...........................................................................................................................................................................40Gamen Elisabetta ................................................................................................................................................................16Garascia Andrea ..........................................................................................................................................................25, 40Garcia Brasca Daniela ......................................................................................................................................................34Garcia Carlos ...........................................................................................................................................................................46Garcia Humberto .................................................................................................................................................................48García-González Maria Pilar ........................................................................................................................................41Garnett Christine ..................................................................................................................................................................10Gattenlöhner Stefan ..........................................................................................................................................................18Gatzoulis Michael A. .................................................................................................................................................... 9, 26Georgios Karanikas ............................................................................................................................................................43Gerald Simonneau ..............................................................................................................................................................39Gerges Christian ...............................................................................................................................23, 35, 40, 43, 46Gerges Mario ......................................................................................................................................23, 35, 40, 43, 46Gerhardt Felix ..............................................................................................................................................31, 33, 38, 40Ghandour Mohamedanwar ........................................................................................................................................49Ghigna Maria Rosa ....................................................................................................................................................18, 17Ghio Stefano ...................................................................................................................................................................21, 38Ghofrani Hossein-Ardeschir .................................................................................12, 18, 21, 24, 32, 33, 43Giannakoulas George ....................................................................................................................................26, 27, 31Gibbs Simon ....................................................................................................................................................9, 13, 21, 32Gibietis Valdis .........................................................................................................................................................................46Giglio Ada Francesca ........................................................................................................................................................40Gijsbers Rik ...............................................................................................................................................................................19Gilberg Frank...........................................................................................................................................................................37Gin-Sing Wendy ...........................................................................................................................................................32, 49Giovinazzo Michele ............................................................................................................................................................24

Girerd Barbara .................................................................................................................13, 15, 16, 17, 18, 21, 30Girgis Reda ................................................................................................................................................................................42Giubertoni Ailia .....................................................................................................................................................................16Glaser Simone ........................................................................................................................................................................19Gliozzi Gregorio ....................................................................................................................................................................44Goda Ayumi ....................................................................................................................................................................14, 43Gokhan Sonmez ...................................................................................................................................................................41Goldsman Alejandro .........................................................................................................................................................47Gomberg Maitland Mardi I. .........................................................................................................................................10Gomez Alvarez Enrique ..................................................................................................................................................48Gómez Sánchez Miguel Angel .................................................................................................................................32Gomez Santa Maria Hector ................................................................................................................................23, 29Gonzales-Barlatay Francisco .......................................................................................................................................48Gonzalez Miguel ..................................................................................................................................................................29Gonzalez Nicolas..................................................................................................................................................................29Gopalan Deepa .........................................................................................................................................................................9Goto Yoichi ................................................................................................................................................................................44Gotti Enrico ......................................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Gouadon Elodie ...................................................................................................................................................................16Gräf Stefan ........................................................................................................................................................................13, 21Grancelli Hugo .......................................................................................................................................................................29Granton John ..........................................................................................................................................................................10Gravellone Miriam ..............................................................................................................................................................16Gregorc Teja .............................................................................................................................................................................23Gregorietti Vanesa ..............................................................................................................................................................34Grimminger Friedrich ..............................................................................................................................................16, 18Grippo Maria ...........................................................................................................................................................................47Grünberg Katrien .................................................................................................................................................................15Grünig Ekkehard .........................................................................................10, 14, 16, 20, 29, 32, 33, 38, 39Grunig Gabriele ....................................................................................................................................................................16Grzegorz Kopec ....................................................................................................................................................................33Guarino Daniele ....................................................................................................31, 34, 35, 37, 41, 42, 43, 48Guazzi Marco...........................................................................................................................................................................11Guerrero Oscar ......................................................................................................................................................................40Guignabert Christophe .........................................................................................................8, 15, 18, 19, 28, 30Gumbiene Lina ......................................................................................................................................................................38Guth Stefan ...............................................................................................................................................................................43Guzman Silvia .........................................................................................................................................................................48Hacker Marcus ........................................................................................................................................................................43Haddad François ......................................................................................................................................................................9Hadinnapola Charaka .............................................................................................................................................13, 21Hagmanns Henrik................................................................................................................................................................31Haick Hossam .........................................................................................................................................................................30Haimel Matthias ....................................................................................................................................................................21Hajime Kasai ............................................................................................................................................................................43



58


Halank Michael ......................................................................................................................................................................32Hanaoka Masayuki .............................................................................................................................................................22Handoko De Man Frances ............................................................................................................................................38Hansmann Georg ................................................................................................................................................................48Hantash Manal .......................................................................................................................................................................39Happel Christoph ................................................................................................................................................................48Haralambos Karvounis ....................................................................................................................................................27Harari Sergio ...................................................................................................................................................................11, 37Harmjan Bogaard ................................................................................................................................................................23Harris R Scott ...........................................................................................................................................................................24Hartline Brian ...........................................................................................................................................................................38Hartopo Anggoro Budi .................................................................................................................................25, 26, 33Haruka Sato ..............................................................................................................................................................................44Harutyunova Satenik .......................................................................................................................................14, 20, 29Harvey Katie Yates ...............................................................................................................................................................16Hassoun Paul M. .............................................................................................................................................................. 9, 14Hatala Robert ..........................................................................................................................................................................25Hatem Stéphane ..................................................................................................................................................................23Hautefort Aurélie ..............................................................................................................................15, 16, 18, 22, 23Haworth Busk Sheila G. ..................................................................................................................................................12Hekimsoy Vedat ....................................................................................................................................................................25Hellmich Martin .....................................................................................................................................................................40Helmersen Douglas ..................................................................................................................................................32, 33Hemnes Anna R. ............................................................................................................................................................. 9, 38Henault Emilie ........................................................................................................................................................................15Hendriks Rudi..........................................................................................................................................................................23Hennigs Jan ..............................................................................................................................................................................17Henrohn Dan ...........................................................................................................................................................................16Herth Felix ..................................................................................................................................................................................39Heukels Peter ..........................................................................................................................................................................23Hibert Marcel ...........................................................................................................................................................................15Hidenori Moriyama ............................................................................................................................................................22Highland Kristin .....................................................................................................................................................................38Higuchi Tomoaki ...................................................................................................................................................................33Hill Jerrold..................................................................................................................................................................................34Hill Nicholas ..............................................................................................................................................................................19Hinderhofer Katrin .....................................................................................................................................................14, 20Hintz Susan ................................................................................................................................................................................47Hiraide Takahiro ....................................................................................................................................................................24Hirani Naushad ......................................................................................................................................................................33Hirata Ken-Ichi ...............................................................................................................................................................14, 46Hiroaki Shimokawa ............................................................................................................................................................44Hirofumi Sawada ..................................................................................................................................................................14Hiromasa Otake ....................................................................................................................................................................45Hiroshi Ito ...................................................................................................................................................................................27

Hiroyuki Fukushima ............................................................................................................................................................14Hiroyuki Onishi ......................................................................................................................................................................42Hirschson Prado Alfredo ................................................................................................................................................23Hisada Ryo .................................................................................................................................................................................35Hitoshi Yaku ..............................................................................................................................................................................46Hjalmarsson Clara ......................................................................................................................................................26, 33Hodgson Joshua ..................................................................................................................................................................21Hodin Sophie ..........................................................................................................................................................................44Hoeffken Gert .........................................................................................................................................................................45Hoeper Marius M. ..............................................................................................................................................10, 20, 32Hohmann Christopher .....................................................................................................................................................33Holden Simon .........................................................................................................................................................................21Homer Natalie ........................................................................................................................................................................16Homma Satoshi .....................................................................................................................................................................18Honda Junya ...........................................................................................................................................................................18Hoo Teng Yik ...................................................................................................................................................................26, 28Hopkins Susan R. ......................................................................................................................................................................9Horiuchi Toshimichi ............................................................................................................................................................22Hoshikawa Yasushi .....................................................................................................................................................17, 25Houeijeh Ali ..............................................................................................................................................................................21Houweling Arjan C .............................................................................................................................................................21Howard Luke S. ....................................................................................................................................................12, 21, 32Hsu Chih-Hsin .......................................................................................................................................................23, 29, 42Hsu Jong-Hau .........................................................................................................................................................................40Huang Wei-Ming ..................................................................................................................................................................26Huckell Victor F ......................................................................................................................................................................41Huertas Alice ..........................................................................................................................................................15, 18, 19Hull Michael ..............................................................................................................................................................................34Humbert Marc ................8, 13, 15, 16, 17, 18, 19, 21, 22, 23, 28, 30, 31, 32, 33, 39, 42, 46Hummel Regina ....................................................................................................................................................................19Hunt Thomas ...........................................................................................................................................................................39Hyung-Kwan Kim .................................................................................................................................................................34Ichimura Yuki ...........................................................................................................................................................................33Ikeda Shohei ............................................................................................................................................................................41Ikonomidis Ignatios ............................................................................................................................................................36Iloska Dijana .............................................................................................................................................................................43Inami Takumi ...................................................................................................................................................................14, 43Inanc Murat ......................................................................................................................................................................30, 35Ishibashi-Ueda Hatsue .....................................................................................................................................................17Ishiguro Haruhisa ........................................................................................................................................................14, 43Ismail Aidila Binte ................................................................................................................................................................45Isobe Sarasa ....................................................................................................................................................................24, 44Issever Halim ...........................................................................................................................................................................35Itabashi Yuji ......................................................................................................................................................................24, 44Ito Hiroshi ...................................................................................................................................................................................49



59


Ivy Dunbar ........................................................................................................................................................................12, 48Izawa Kazuhiro P ...................................................................................................................................................................46Jaé Nicolas ................................................................................................................................................................................19Jaïs Xavier ..............................................................................................................................................12, 17, 31, 42, 46Jakowitsch Johannes ......................................................................................................................................35, 43, 46Jakub Stepniewski ..............................................................................................................................................................33Jang Shin Yi ..............................................................................................................................................................................28Jansa Pavel .....................................................................................................................................................32, 33, 44, 45Janssen Wiebke ....................................................................................................................................................................24Jaroensri Sutthikiat .............................................................................................................................................................48Jenkins David P. .........................................................................................................................................12, 13, 43, 46Jennifer Bordenave ............................................................................................................................................................18Jeon Chan Hong ..................................................................................................................................................................34Jeries Raneen ..........................................................................................................................................................................30Jevnikar Mitja ..........................................................................................................................................................................31Jin Endo .......................................................................................................................................................................................22Jing Zhi Cheng.......................................................................................................................................................................10Jo Won Jung ............................................................................................................................................................................48John David ................................................................................................................................................................................19Johnson Martin ......................................................................................................................................................................38Jonas Kamil ..............................................................................................................................................................................44Jone Pei-Ni ................................................................................................................................................................................48Jourdon Philippe..................................................................................................................................................................23Jujo Takayuki ................................................................................................................................................35, 43, 46, 47Jung Hae Ok ...................................................................................................................................................................15, 20Jung Jo Won ...................................................................................................................................................................33, 38Jung Se Yong .................................................................................................................................................................33, 38Jung Yoon Kim .......................................................................................................................................................................48Jutant Etienne-Marie .........................................................................................................................................................18K F Oliveira Rudolf ..............................................................................................................................................................23Kaldararova Monika ...............................................................................................................................25, 35, 42, 44Kamil Jonas...............................................................................................................................................................................33Kamolvisit Wuttichart ........................................................................................................................................................48Kanal Yucel ................................................................................................................................................................................46Kanar Batur Gonenc ..........................................................................................................................................................29Kap Miriam ................................................................................................................................................................................38Kaptan Ozen Deniz ............................................................................................................................................................29Karatancheva Blagorodna ............................................................................................................................................31Kariofillis Panagiotis ..................................................................................................................................................26, 27Karlocai Kristof .......................................................................................................................................................................45Karvounis Haralambos ..................................................................................................................................26, 27, 31Kataoka Masaharu ...................................................................................................................................14, 24, 43, 44Kato Masaru ....................................................................................................................................................................29, 35Katsuya Kozu ...........................................................................................................................................................................44Kawaguchi Yasushi .............................................................................................................................................................33

Kawakami Takashi ......................................................................................................................................................24, 44Kawamori Hiroyuki .............................................................................................................................................................14Kawut Steven M. ............................................................................................................................................................. 9, 19Kazufumi Nakamura ..........................................................................................................................................................27Kazuhiko Nakayama ........................................................................................................................................22, 42, 45Kazuya Miyagawa ...............................................................................................................................................................22Keating Mike ............................................................................................................................................................................38Keiichi Fukuda ...............................................................................................................................................................22, 45Keiichi Ishida ............................................................................................................................................................................43Keiichi Itatani............................................................................................................................................................................46Keiko Ohta-Ogo ...................................................................................................................................................................44Kempny Aleksander ..........................................................................................................................................................26Ken-Ichi Hirata ...............................................................................................................................................................42, 45Kenichi Yanaka ..............................................................................................................................................................42, 45Kentaro Ejiri ..............................................................................................................................................................................27Keogh Anne .............................................................................................................................................................................46Keogh Anne M..............................................................................................................................................................10, 36Kepez Alper ..............................................................................................................................................................................29Kerbaul Francois ...................................................................................................................................................................23Keshavarz Ali ...........................................................................................................................................................................15Kessler Romain ......................................................................................................................................................................22Khanna Dinesh ...........................................................................................................................................................................9Khatib Salam ............................................................................................................................................................................30Khrisanapant Wilaiwan ...................................................................................................................................................25Ki Chang Seok ........................................................................................................................................................................28Kiely David G. .......................................................................................................................................................13, 21, 38Kigitovica Dana .....................................................................................................................................................................46Kikuchi Hanako .............................................................................................................................................................14, 43Kikuchi Nobuhiro ......................................................................................................................................17, 25, 39, 41Kiliçkiran Avci Burçak ...............................................................................................................................................34, 44Kim Duk-Kyung ...................................................................................................................................................15, 28, 38Kim Hyung Kwan .................................................................................................................................................................38Kim Kye Hun ............................................................................................................................................................................44Kim Kyung-Hee ............................................................................................................................................................20, 39Kim Minsu ..................................................................................................................................................................................39Kim Nick H. ......................................................................................................................................................................12, 38Kim So Ree ................................................................................................................................................................................28Kim Sung Mok ........................................................................................................................................................................28Kim Tae Jung ...........................................................................................................................................................................28Kimio Satoh ..............................................................................................................................................................................39Kimura Mai .......................................................................................................................................................................24, 44Kimura Taizo .............................................................................................................................................................................18Kinota Fumiya .........................................................................................................................................................................22Kioka Hidetaka .......................................................................................................................................................................40Kirchgaessler Klaus-Uwe ...............................................................................................................................................37



60


Kitaichi Masanori ..................................................................................................................................................................17Kjellström Barbro ...............................................................................................................................................26, 33, 45Klassen Preston......................................................................................................................................................................36Kleinjung Frank ......................................................................................................................................................................39Klepetko Walter .........................................................................................................................................10, 43, 45, 46Klingel-Schmitt Isabelle ..................................................................................................................................................13Klinger James R. ............................................................................................................................................................. 8, 19Klose Hans .................................................................................................................................................................................32Klotsche Jens ..........................................................................................................................................................................32Klyaus Nataliya .......................................................................................................................................................................29Knox Michael ...........................................................................................................................................................................42Kobayashi Nobumitsu .....................................................................................................................................................22Kobayashi Seimi ...................................................................................................................................................................14Kocakaya Derya ....................................................................................................................................................................29Koep Eleena .............................................................................................................................................................................34Kohli Puja ....................................................................................................................................................................................24Kohno Takashi................................................................................................................................................................24, 44Koichiro Sugimura ...............................................................................................................................................................44Koichiro Tatsumi ...........................................................................................................................................................17, 43Koji Ikeda ....................................................................................................................................................................................22Kojonazarov Baktybek ............................................................................................................................................18, 24Kolb Todd ...................................................................................................................................................................................14Kolios Marios ...........................................................................................................................................................................31Konagai Nao ............................................................................................................................................................................44Konstandinides Stavros .........................................................................................................................................26, 27Konstantonis Dimitrios ..................................................................................................................................19, 31, 35Kool Mirjam ..............................................................................................................................................................................23Kopec Grzegorz ..................................................................................................................................................36, 44, 45Kostantonis Dimitris ...........................................................................................................................................................36Kotsimbos Tom ......................................................................................................................................................................23Kotylar Eugene ......................................................................................................................................................................46Koudstaal Thomas...............................................................................................................................................................23Kovacs Gabor.................................................................................................................................................................21, 38Kramer Tilmann ..........................................................................................................................................31, 33, 38, 40Kreitner Karl-Friedrich ......................................................................................................................................................19Krombach Gabriele ...........................................................................................................................................................18Krowka Michael .........................................................................................................................................................................9Kubota Kana ............................................................................................................................................................................26Kucukoglu Mehmet Serdar..........................................................................................................................................26Kühn Christian ........................................................................................................................................................................10Kukongviriyapun Upa ......................................................................................................................................................25Kultursay Hakan ....................................................................................................................................................................29Kuniyoshi Fukai ......................................................................................................................................................................46Künne Carsten ........................................................................................................................................................................20Kurabayashi Masahiko .....................................................................................................................................................48

Kurosawa Ryo ..............................................................................................................................................17, 25, 39, 41Kwon Hee-Jin .................................................................................................................................................................40, 41Kwon Woo Chan ..................................................................................................................................................................28Kylhammar David ..............................................................................................................................................26, 33, 45Kyung-Hee Kim .....................................................................................................................................................................34Kyzymly Aigun ........................................................................................................................................................................24Lacharite-Roberge Anne-Sophie ............................................................................................................................47Lambert Melanie ..............................................................................................................................15, 16, 17, 22, 23Lang Irene ..................................................................................................................11, 13, 23, 35, 40, 43, 45, 46Lange Tobias ...................................................................................................................................................................32, 34Langholz David ......................................................................................................................................................................42Langleben David ...................................................................................................................................................9, 24, 32Larsson Marita ........................................................................................................................................................................16Lau-Walker Margaret ........................................................................................................................................................32Laurent Savale ........................................................................................................................................................................39Lavalle Cobo Augusto ............................................................................................................................................23, 29Lawrie Allan ..............................................................................................................................................................................21Lecerf Florence ....................................................................................................................................................15, 16, 18Lechner Klaus ..........................................................................................................................................................................43Lee Byeong-Ju ..............................................................................................................................................................15, 34Lee Geraldine .........................................................................................................................................................................32Lee Ju-Hee .......................................................................................................................................................................40, 41Lee Jun Soo ..............................................................................................................................................................................20Lee Lisa .........................................................................................................................................................................................41Lee Sang Eun...........................................................................................................................................................................33Lee Shin-Seok .........................................................................................................................................................................34Lee William ................................................................................................................................................................................47Lehmkuhl Hans ......................................................................................................................................................................39Lekakis John ....................................................................................................................................................................35, 36Leroy Anne ................................................................................................................................................................................21Lescano Adrian ....................................................................................................................................................23, 29, 34Lescano Miguel .....................................................................................................................................................................40Levy Marilyne ..........................................................................................................................................................................21Levy Robert D..........................................................................................................................................................................41Lewis Michael I. ......................................................................................................................................................................10Leys Mathias .............................................................................................................................................................................19Li Caiyun ......................................................................................................................................................................................17Li Wei .............................................................................................................................................................................................21Liao Ronglih ..............................................................................................................................................................................23Lickert Cassandra .................................................................................................................................................................34Liebetrau Christoph ...........................................................................................................................................................43Lim Choong Hee .........................................................................................................................................................28, 45Lim Soo Teik ...........................................................................................................................................................26, 43, 45Lima Joao ...................................................................................................................................................................................19Lindner Jaroslav ...........................................................................................................................................................44, 45



61


Liu Bin ............................................................................................................................................................................................21Liu Wei-Shin ..............................................................................................................................................................................29Loh Kenny Wei-Tsen ..................................................................................................................................................43, 45Looso Mario .............................................................................................................................................................................20Lorenz Hanns-Martin .........................................................................................................................................................14Low Andrea .....................................................................................................................................................................26, 28Loyd James E. .............................................................................................................................................................................8Lu Wei-Da ...................................................................................................................................................................................29Lumens Joost ..............................................................................................................................................................................9Lunardi Claudio .....................................................................................................................................................................49Lutz Katie ....................................................................................................................................................................................13Ly Tu .......................................................................................................................................................................................15, 18Lydell Carmen .........................................................................................................................................................................33Macera Francesca ................................................................................................................................................................40Machado Ferreira Eloara ...............................................................................................................................................23Machado Rajiv D ..................................................................................................................................................................21Mackenzie Alison .................................................................................................................................................................38Mackenzie Ross Robert V ..............................................................................................................................................21Maclean Margaret ......................................................................................................................................................16, 23Madani Michael M. .............................................................................................................................................................12Magon Wojciech .........................................................................................................................................................36, 44Mairbäurl Heimo ..................................................................................................................................................................20Mal Herve ...................................................................................................................................................................................42Malikov Kirill .............................................................................................................................................................................29Mallet Christine......................................................................................................................................................................19Mamazhakypov Argen ....................................................................................................................................................24Manes Alessandra ................................................................................9, 31, 34, 35, 37, 40, 41, 42, 43, 48Manginas Athanasios ............................................................................................................................26, 27, 31, 44Manoury Boris ...............................................................................................................................................................16, 22Marcin Waligora ....................................................................................................................................................................33Margelidon-Cozzolino Victor .....................................................................................................................................44Maria Toumpourleka .........................................................................................................................................................27Marino Paolo Nicola ..........................................................................................................................................................16Marques Maria Adelia......................................................................................................................................................48Marra Alberto Maria .................................................................................................................................................14, 29Marti Fuster Berta.................................................................................................................................................................24Martin Jennifer M .................................................................................................................................................................21Martin Lisa ..................................................................................................................................................................................13Martin-Suarez Sofia ............................................................................................................................................................44Martinez Fernando Jose.................................................................................................................................................11Martinez Ines ...........................................................................................................................................................................48Martínez-Dolz Luis ...............................................................................................................................................................35Martynyuk Tamila ........................................................................................................................................................35, 36Maruyama Hidekazu ................................................................................................................................................17, 18Masaharu Kataoka .....................................................................................................................................................22, 45

Masaki Matsushima............................................................................................................................................................14Masanori Yasuo .....................................................................................................................................................................42Masashi Yanagisawa ..........................................................................................................................................................22Masayuki Hanaoka .............................................................................................................................................................42Mascherbauer Regina ......................................................................................................................................................32Maslyanskiy Alexey ............................................................................................................................................................29Mateo Maria Paz ...................................................................................................................................................................27Mathai Stephen C.......................................................................................................................................................10, 14Matijasevic Jovan .................................................................................................................................................................29Matsubara Hiromi .....................................................................................................................................12, 17, 34, 43Matthieu Turpin .....................................................................................................................................................................39Mayer Eckhard .....................................................................................................................................................12, 13, 43Mccabe Colm ..........................................................................................................................................................................26McGoon Michael D. ...........................................................................................................................................................12McLaughlin Vallerie V. .....................................................................................................................8, 10, 12, 36, 38Mehta Sanjay ...........................................................................................................................................................................12Meier Christian ..............................................................................................................................................................32, 33Melendez Eduardo.............................................................................................................................................................48Melero-Ferrer Josep Lluís ..............................................................................................................................................35Ménoret Séverine ................................................................................................................................................................16Mercier Olaf..............................................................................................................................................................................17Mercurio Valentina ..............................................................................................................................................................14Mergenthaler Nicoletta ...................................................................................................................................................34Merkus Daphne ..................................................................................................................................................15, 23, 25Messina Carolina M.S. ......................................................................................................................................................23Meziani Ferhat ........................................................................................................................................................................22Michalik Katharina ...............................................................................................................................................................19Michel Jean-Baptiste .........................................................................................................................................................23Michiels Annelies .................................................................................................................................................................19Mielniczuk Lisa .......................................................................................................................................................................32Milutinov Senka .....................................................................................................................................................................29Mitrakou Cornelia ................................................................................................................................................................31Mitrouska Ioanna ........................................................................................................................................................26, 27Mitsushige Murata .....................................................................................................................................................22, 45Miyagawa Kazuya ...............................................................................................................................................................17Miyashita Yohei ......................................................................................................................................................................40Miyata Satoshi ......................................................................................................................................................17, 25, 41Miyauchi Takashi ...................................................................................................................................................................18Miyawaki Hiroshi ..................................................................................................................................................................40Moghaddam Nima .............................................................................................................................................................41Mogulkoc Nesrin ..................................................................................................................................................................29Moiseeva Olga ..............................................................................................................................................................24, 29Mokin Egor ...............................................................................................................................................................................17Mokina Natalia .......................................................................................................................................................................17Moledina Shahin ..................................................................................................................................................................21



62


Möllmann Christian ............................................................................................................................................................19Monassier Laurent ...............................................................................................................................................................22Montani David .......................................................................9, 13, 15, 16, 17, 18, 21, 22, 23, 30, 31, 42Monti Enrico ....................................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Morales-Cano Daniel ........................................................................................................................................................17Morell-Cabedo Salvador ...............................................................................................................................................41Moreno Laura..........................................................................................................................................................................17Moreo Antonella ..................................................................................................................................................................25Morita Yoshiaki .......................................................................................................................................................................44Moriyama Hidenori ............................................................................................................................................................24Moros Claudio ........................................................................................................................................................................47Morrell Nicholas W. ....................................................................................................................................8, 13, 16, 21Moser Bernhard ....................................................................................................................................................................43Motoji Yoshiki ..........................................................................................................................................................................24Mouratoglou Sofia-Anastasia ...........................................................................................................................26, 27Muecke Christian .................................................................................................................................................................16Multing Jonas .........................................................................................................................................................................33Munehisa Bekki .....................................................................................................................................................................36Murakami Noriko .................................................................................................................................................................12Murata Mitsushige .....................................................................................................................................................24, 44Musca Francesco ..................................................................................................................................................................25Mutlu Bulent .............................................................................................................................................................................29Naeije Robert .........................................................................................................................................9, 23, 24, 38, 40Naessén Tord ...........................................................................................................................................................................16Nagel Christian .............................................................................................................................................................14, 39Naing Pyi .....................................................................................................................................................................................41Nair Athira ..................................................................................................................................................................................47Naito Akira .............................................................................................................................................17, 35, 43, 46, 47Naka Katerina .......................................................................................................................................................26, 27, 27Nakamura Hiroyuki....................................................................................................................................................29, 35Nakamura Kazufumi ..........................................................................................................................................................49Nakanishi Michio .........................................................................................................................................................44, 44Nakanishi Norifumi .............................................................................................................................................................17Nakayama Kazuhiko ........................................................................................................................................14, 46, 46Nakhleh Morad K......................................................................................................................................13, 16, 18, 30Nakwan Narongsak ...........................................................................................................................................................48Naohiko Nakanishi .............................................................................................................................................................46Naoki Okumura ............................................................................................................................................................28, 42Naoki Tamada .......................................................................................................................................................22, 42, 45Naseva Emilia..........................................................................................................................................................................31Nathan Steven D .........................................................................................................................................................37, 11Natsina Kristiana ...................................................................................................................................................................38Nattmann Phillip ...................................................................................................................................................................33Nayakanti Sreenath Reddy ..........................................................................................................................................24Newnham Michael ....................................................................................................................................................13, 21

Ng Choo ......................................................................................................................................................................................13Nguyen Thomas ..........................................................................................................................................................34, 40Nichols Bill .................................................................................................................................................................................20Nichols William ................................................................................................................................................................ 8, 13Nicholson Gail ........................................................................................................................................................................49Nicolls Mark R. ............................................................................................................................................................................8Nisell Magnus ................................................................................................................................................................26, 33Nishimura Masaharu ................................................................................................................................................29, 35Nishimura Rintaro ..............................................................................................................................................35, 46, 47Nitsche Alejandro ................................................................................................................................................................23Nobuhiro Tahara ...................................................................................................................................................................36Nobuhiro Tanabe ........................................................................................................................................................17, 43Nobuhiro Yaoita ....................................................................................................................................................................44Nogi Masamichi ................................................................................................................................17, 25, 39, 39, 41Noriaki Emoto ......................................................................................................................................................22, 42, 45Noriyuki Negi ..........................................................................................................................................................................45Normand Patrick ...................................................................................................................................................................39Nossent Esther ..............................................................................................................................................................15, 17Nötzold René Reiner .........................................................................................................................................................20Ntai Konstantina ...................................................................................................................................................................31Ntellos Christos .....................................................................................................................................................................31Ntiloudi Despina ..................................................................................................................................................................31O’brien Gerald .......................................................................................................................................................................39Ogawa Aiko..............................................................................................................................................................................34Ogo Takeshi ...........................................................................................................................................................12, 44, 44Oh Seyeon ...............................................................................................................................................................15, 20, 39Ohh Jin Kyung........................................................................................................................................................................40Ohira Hiroshi ...................................................................................................................................................................29, 35Ohta-Ogo Keiko ...................................................................................................................................................................17Ohtani Tomohito ..................................................................................................................................................................40Ohtsuki Tomohiro .......................................................................................................................................................25, 41Oka Teruaki ...............................................................................................................................................................................17Okada Yoshinori ..........................................................................................................................................................17, 25Okita Yutaka .............................................................................................................................................................................14Oksul Metin ..............................................................................................................................................................................25Oku Kenji ...........................................................................................................................................................................29, 35Okumus Gulfer .............................................................................................................................................................30, 35Oliva Fabrizio ..........................................................................................................................................................................40Olivares Araceli ......................................................................................................................................................................48Olivier Sitbon ..........................................................................................................................................................................39Olschewski Andrea J. ................................................................................................................................................. 8, 21Olschewski Horst ...............................................................................................................................................11, 21, 38Olsson Karen M. ...................................................................................................................................................................11Omura Junichi ....................................................................................................................................17, 25, 39, 39, 41Öngen Gül .................................................................................................................................................................................44



63


Ongen Hurrem Gul ............................................................................................................................................................34Ongen Zeki ...............................................................................................................................................................................34Onishi Hiroyuki ....................................................................................................................................................14, 45, 46Orfanos Stylianos ..........................................................................................................19, 24, 26, 27, 31, 35, 36Orhan Gokcen ........................................................................................................................................................................30Orlova Kristina ........................................................................................................................................................................40Osa-Sáez Ana ..........................................................................................................................................................................35Osamu Yamada .....................................................................................................................................................................14Ota Masao .................................................................................................................................................................................22Otake Hiromasa ...........................................................................................................................................................14, 46Otshuki Tomohiro ................................................................................................................................................................39Otsu Kazuya .............................................................................................................................................................................18Oudiz Ronald J. .........................................................................................................................................................................9Ouwehand Willem H ........................................................................................................................................................21Ouyang Pamela .....................................................................................................................................................................19Ozcan Kahraman Buse ....................................................................................................................................................31Ozpelit Ebru .............................................................................................................................................................................31Ozsoy Ismail .............................................................................................................................................................................31P Ramos Roberta ..................................................................................................................................................................23Pacak Jozef ................................................................................................................................................................................44Pacini Davide ...........................................................................................................................................................................44Padmanabhan Menon Divya ......................................................................................................................................49Palabiyik Mert .........................................................................................................................................................................26Palaiodimos Leonidas ......................................................................................................................................................36Palazzini Massimiliano....................................................................11, 31, 34, 35, 37, 40, 41, 42, 43, 48Palevsky Harold .....................................................................................................................................................................19Palmisciano Amy ..................................................................................................................................................................19Pan Zixuan .................................................................................................................................................................................20Panagiotidou Evangelia ...............................................................................................................................26, 27, 34Panzenböck Adelheid ......................................................................................................................................................46Papaioannou Andriana ...................................................................................................................................................35Papiris Spyros ..........................................................................................................................................................................35Pappas Athanasios ............................................................................................................................................19, 31, 35Papy-Garcia Dulce ...............................................................................................................................................................15Parati Gianfranco ..................................................................................................................................................................40Park Han Ki ..............................................................................................................................................................33, 34, 38Park Hyukjin ..............................................................................................................................................................................44Park Jae-Hyeong .........................................................................................................................................................40, 41Park Jong Chun .....................................................................................................................................................................44Park Taek Kyu ..........................................................................................................................................................................28Park Young Hwan ........................................................................................................................................................33, 38Parmentier Gilles ..................................................................................................................................................................13Pasca Filippo ............................................................................................................31, 34, 35, 37, 41, 42, 43, 48Pasurivong Orapin ..............................................................................................................................................................25Patel Jigisha ..............................................................................................................................................................................37

Patuzzo Giuseppe................................................................................................................................................................49Pauciulo Michael...................................................................................................................................................................13Pavlidis George .....................................................................................................................................................................36Peacock Andrew J. ...................................................................................................................................11, 13, 21, 38Peloquin Grace ......................................................................................................................................................................14Pena Janethe De Oliveira ..............................................................................................................................................33Pepke-Zaba Joanna .......................................................................................................................11, 13, 21, 32, 46Perdomo-Londoño Diana .............................................................................................................................................41Perez Solène ............................................................................................................................................................................13Perez-Vizcaino Francisco ................................................................................................................................................17Perna Enrico .............................................................................................................................................................................40Perrone Sergio........................................................................................................................................................................34Perros Frédéric ..............................................................................................13, 15, 16, 17, 18, 22, 23, 30, 45Peter Dorfmüller ..........................................................................................................................................................18, 23Pezzuto Beatrice....................................................................................................................................................................24Phan Carole ............................................................................................................................................................15, 18, 19Phua Ghee Chee .......................................................................................................................................26, 28, 43, 45Piccinino Cristina ..................................................................................................................................................................16Pinder Diane ............................................................................................................................................................................19Piotr Podolec............................................................................................................................................................................33Pistritto Anna Maria ...................................................................................................................................................23, 40Pitsiou Georgia ....................................................................................................................................................26, 27, 34Pitsis Antonios.........................................................................................................................................................................31Pittrow David ...........................................................................................................................................................................32Planche Olivier .......................................................................................................................................................................46Platt David ..................................................................................................................................................................................39Playford David ...............................................................................................................................................................30, 41Poble Paul-Benoit ........................................................................................................................................................18, 19Podolec Piotr...................................................................................................................................................................36, 44Pollock Eks Wye ....................................................................................................................................................................32Poms Abby ................................................................................................................................................................................20Ponce Derek .............................................................................................................................................................................19Postadzhiyan Arman..........................................................................................................................................................31Pradhan Kabita ......................................................................................................................................................................24Preston Ioana R. ............................................................................................................................................................10, 19Prevot Grégoire .....................................................................................................................................................................21Price Laura .................................................................................................................................................................................26Prokopenko Inga ..................................................................................................................................................................21Provencher Steeve ..............................................................................................................................................................11Pruett Janis ................................................................................................................................................................................34Publig Max .................................................................................................................................................................................43Pulido Tomas ...........................................................................................................................................................................10Pullamsetti Soni ............................................................................................................................................................18, 19Pullamsetti Soni Savai ......................................................................................................................8, 16, 20, 24, 43Pussadhamma Burabha .................................................................................................................................................25



64


Pyatin Vasily ..............................................................................................................................................................................17Pylawka Serhiy ........................................................................................................................................................................16Quah Kevin ...............................................................................................................................................................................45Quarck Rozenn ....................................................................................................................................................18, 19, 45Quatredeniers Marceau .................................................................................................................................................16Quilindro Alberto .................................................................................................................................................................47Rabinovitch Marlene ................................................................................................................................................... 8, 17Raboisson Maire-Josee ...................................................................................................................................................48Radchenko Ganna .....................................................................................................................................................28, 36Rådegran Göran .................................................................................................................................................26, 30, 33Radhakrishnan Ramya .....................................................................................................................................................24Rahaghi Farbod .....................................................................................................................................................................24Rahaghi Franck ......................................................................................................................................................................33Rainisio Maurizio ..................................................................................................................................................................10Rallidis Loukianos .......................................................................................................................................................35, 36Raman Subha ..........................................................................................................................................................................32Rammos Spyridon .............................................................................................................................................26, 27, 31Rancati Julieta .........................................................................................................................................................................48Ranchoux Benoit ................................................................................................................................................15, 16, 18Raphaël Thuillet ............................................................................................................................................................15, 18Rapp Ulf .......................................................................................................................................................................................18Rasul Niazi Zahid ..................................................................................................................................................................22Raymond Nicolas .................................................................................................................................................................16Raza Farhan ..............................................................................................................................................................................47Reis Abílio ..................................................................................................................................................................................38Reis e Sousa Caetano .......................................................................................................................................................23Reiss Irwin Karl .......................................................................................................................................................................25Remkova Anna .......................................................................................................................................................................44Reptova Adriana ...................................................................................................................................................................25Reynaud-Gaubert Martine ...........................................................................................................................................21Rhodes Christopher J .......................................................................................................................................................21Richter Manuel .......................................................................................................................................................................43Ridocci-Soriano Francisco .............................................................................................................................................41Rika Suda ....................................................................................................................................................................................43Rimouche Asma ....................................................................................................................................................................24Rinaldi Andrea ...............................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Rintaro Nishimura ................................................................................................................................................................43Riou Marianne ........................................................................................................................................................................18Ristic Arsen D ..........................................................................................................................................................................36Rizos Michalis .................................................................................................................................................................19, 31Roberts Kari ..............................................................................................................................................................................19Rodriguez Viales Rebecca ...................................................................................................................................14, 20Romer Lewis ....................................................................................................................................................................15, 47Romero Guadalupe ...........................................................................................................................................................29Rondelet Benoit ....................................................................................................................................................................23

Roscigno Robert ...................................................................................................................................................................39Rosenkranz Stephan ..........................................................................................11, 19, 31, 32, 33, 38, 39, 40Ross James ................................................................................................................................................................................24Rossbach Oliver ....................................................................................................................................................................19Rotunno Mariangela..........................................................................................31, 34, 35, 37, 41, 42, 43, 48Royal Mike .................................................................................................................................................................................39Ruan Wen ........................................................................................................................................................26, 28, 43, 45Rubin Lewis J. ..................................................................................................................................................8, 10, 12, 36Rucker-Martin Catherine .......................................................................................................................................16, 23Rueda-Soriano Joaquín ..................................................................................................................................................35Rundqvist Bengt ...................................................................................................................................................................33Ruopp Nicole ..........................................................................................................................................................................27Russo Claudio .........................................................................................................................................................................40Rygkov Anton .........................................................................................................................................................................24Ryo Konno .................................................................................................................................................................................44Ryosuke Kikuchi ....................................................................................................................................................................28Ryu Jeongwon .....................................................................................................................................................15, 20, 39S Ota-Arakaki Jaquelina .................................................................................................................................................23Sa Silin ...........................................................................................................................................................................................17Sachiyo Igata ...........................................................................................................................................................................36Sadushi-Kolici Roela ........................................................................................................................................35, 43, 45Safdar Zeenat ..........................................................................................................................................................................10Saidova Marina ......................................................................................................................................................................35Saito Toshie ...............................................................................................................................................................................17Saito Yoshiro.............................................................................................................................................................................17Sakai Satoshi ...................................................................................................................................................................17, 18Sakao Seiichiro ............................................................................................................................................17, 35, 46, 47Sakata Yasushi ........................................................................................................................................................................40Salazar Ylia.................................................................................................................................................................................18Salgado Antonio...................................................................................................................................................................48Salmon Richard M ...............................................................................................................................................................21Salobir Barbara ......................................................................................................................................................................45Samakovalis Christos ........................................................................................................................................................16Samarzija Miroslav ..............................................................................................................................................................45San José Estépar Raúl ......................................................................................................................................................24Sánchez-Álvarez Sergio ..................................................................................................................................................41Sanders Jadyn ........................................................................................................................................................................43Sandqvist Anna ......................................................................................................................................................................45Sanfiorenzo Céline .............................................................................................................................................................21Santos Mário ............................................................................................................................................................................38Saori Yamamoto ...................................................................................................................................................................44Sarasa Isobe ....................................................................................................................................................................22, 45Sarashina Toshihiro .............................................................................................................................................................49Sardella Angela .....................................................................................................................................................................47Sari Alper ....................................................................................................................................................................................25



65


Sasmaz Hatice.........................................................................................................................................................................46Satoaki Matoba .....................................................................................................................................................................46Satoh Kimio ...................................................................................................................................................17, 25, 39, 41Satoh Taijyu ....................................................................................................................................................17, 25, 39, 41Satoh Toru ..........................................................................................................................................................9, 14, 17, 43Satomi-Kobayashi Seimi ................................................................................................................................................46Satoshi Akagi ...........................................................................................................................................................................27Savai Rajkumar .....................................................................................................................................................16, 18, 43Savale Laurent .............................................................................................................................................10, 17, 31, 42Savci Sema ................................................................................................................................................................................31Sawa Yoshiki .............................................................................................................................................................................40Saxer Stéphanie ....................................................................................................................................................................16Scalia Gregory ...............................................................................................................................................................30, 41Scelsi Laura ...............................................................................................................................................................................21Schäfer Michal ........................................................................................................................................................................48Schaffarich Michael ............................................................................................................................................................43Schermuly Ralph T. .....................................................................................................................................8, 18, 24, 43Scheuer Sarah .........................................................................................................................................................................46Schini-Kerth Valérie ............................................................................................................................................................22Schlesinger Robert .............................................................................................................................................................24Schmoranzer Mario ............................................................................................................................................................20Schwarzinger Ilse .................................................................................................................................................................43Schwenger Vedat.................................................................................................................................................................39Screaton Nicholas ................................................................................................................................................................13Se Yong Jung ..........................................................................................................................................................................48Seeger Werner .......................................................................................................11, 16, 18, 19, 20, 21, 24, 43Seferian Andrei .............................................................................................................................................................13, 18Seiichiro Sakao ..............................................................................................................................................................17, 43Seimi Satomi-Kobayashi ................................................................................................................................................45Sekine Ayumi ..........................................................................................................................................................................19Semenza Gregg ....................................................................................................................................................................16Sener Yusuf Ziya ....................................................................................................................................................................25Senol Hande ............................................................................................................................................................................47Sentürk Bihter .........................................................................................................................................................................31Seong Seok-Woo .................................................................................................................................................................40Sevinç Can .................................................................................................................................................................................31Sewa Duu Wen ....................................................................................................................................................28, 43, 45Sezgin Dilek ..............................................................................................................................................................................31Shamardina Olga .................................................................................................................................................................21Shamdani Sara .......................................................................................................................................................................15Sharokh Taghavi ....................................................................................................................................................................43Sheares Karen .........................................................................................................................................................................13Shen Lei .......................................................................................................................................................................................37Shi Minyi ......................................................................................................................................................................................17Shigeta Yohei ..........................................................................................................................................................................43

Shigetake Shimokata ...............................................................................................................................................28, 42Shigetoyo Kogaki ................................................................................................................................................................14Shih-Hsien Sung ....................................................................................................................................................................23Shimizu Toru ....................................................................................................................................................................39, 41Shimokawa Hiroaki .................................................................................................................................17, 25, 39, 41Shin Yu Lim .......................................................................................................................................................................33, 38Shingo Kasahara ...................................................................................................................................................................27Shinke Toshiro ................................................................................................................................................................14, 46Shinkura Yuto .................................................................................................................................................................14, 46Shinobu Gamou....................................................................................................................................................................22Shinsuke Shimoyama .......................................................................................................................................................45Shiro Adachi .............................................................................................................................................................................28Shiro Ishikawa .........................................................................................................................................................................14Shozaburo Doi .......................................................................................................................................................................14Shumpei Mori .........................................................................................................................................................................45Shunsuke Tatebe ..................................................................................................................................................................44Sicurello Maria ........................................................................................................................................................................47Siddique Mohammad Abdul Hai .......................................................................................17, 25, 39, 39, 41Sihuayro Ana............................................................................................................................................................................40Simakova Maria ............................................................................................................................................................24, 29Simkova Iveta ......................................................................................................................................25, 35, 42, 44, 45Simonneau Gérald ......................................................................... 8, 9, 12, 13, 15, 17, 31, 32, 33, 42, 46Simpson Michael ..................................................................................................................................................................13Sirenko Yurii .....................................................................................................................................................................28, 36Sitbon Olivier ......................................................................................................................................10, 17, 18, 31, 42Skoro-Sajer Nika ........................................................................................................................................35, 43, 45, 46Skride Andris ..................................................................................................................................................................38, 46Šmite Daina ..............................................................................................................................................................................38Snijder Repke ..........................................................................................................................................................................32Snyder Michael ......................................................................................................................................................................17Söderberg Stefan ................................................................................................................................................................45Son Kuk Hui ............................................................................................................................................................15, 20, 39Song Jie ..............................................................................................................................................................................14, 20Song Jin Young ......................................................................................................................................................................28Song Ju Sun .............................................................................................................................................................................28Song Shin-Jeong ..................................................................................................................................................................38Sood Namita ...................................................................................................................................................................36, 39Soplopuco Christian ..........................................................................................................................................................40Soranzo Nicole ..............................................................................................................................................................13, 21Sorimachi Hidemi ................................................................................................................................................................48Soto Herman ...........................................................................................................................................................................48Soubrier Florent ............................................................................................................................................8, 15, 17, 21Sourla Evdokia .......................................................................................................................................................................34Southgate Laura ....................................................................................................................................................................21Southwood Mark .................................................................................................................................................................21



66


Souza Rogerio ............................................................................................................................................................................9Spreemann Till .......................................................................................................................................................................48Stagaki Eleni..................................................................................................................................................26, 27, 31, 35Stam Kelly...................................................................................................................................................................................25Stanopoulos Ioannis ..........................................................................................................................................................34Stavros Hadjimiltiades .....................................................................................................................................................27Stenmark Kurt R. .......................................................................................................................................................................8Stepffer Carolina ...................................................................................................................................................................48Stepniewski Jakub .....................................................................................................................................................36, 44Steringer-Mascherbauer Regina .............................................................................................................................45Stevens Scott ...........................................................................................................................................................................43Stewart Traci .............................................................................................................................................................................49Stockbridge Norman ........................................................................................................................................................10Storn Samantha .....................................................................................................................................................................18Strange Geoff .................................................................................................................................................................30, 41Strautmane Sintija ...............................................................................................................................................................46Stylianos Orfanos .................................................................................................................................................................36Su Po-Lan ....................................................................................................................................................................................42Suberbielle Caroline ..........................................................................................................................................................13Suda Rika ..................................................................................................................................................................35, 46, 47Sugawara Eri ...................................................................................................................................................................29, 35Sugiura Toshihiko ........................................................................................................................................................35, 46Sumer Celik .....................................................................................................................................................................30, 35Sumner Kelli .............................................................................................................................................................................43Sunamura Shinichiro ..............................................................................................................................17, 25, 39, 41Sung Shih-Hsien ....................................................................................................................................................................26Suntharalingam Jay ...........................................................................................................................................................21Suriany Silvie ............................................................................................................................................................................19Suzuki Kota................................................................................................................................................................................41Suzuki Yoko ...............................................................................................................................................................................22Swietlik Emilia .........................................................................................................................................................................21Swiston John ...........................................................................................................................................................................41Sydykov Akylbek ..................................................................................................................................................................24Szmuszkovicz Jacqueline ..............................................................................................................................................19Taboada Dolores ..................................................................................................................................................................13Tacchella Gloria .....................................................................................................................................................................49Tacy Theresa ...........................................................................................................................................................22, 28, 47Taghavi Shahrokh ................................................................................................................................................................43Takagi Kae .................................................................................................................................................................................33Takahiro Hiraide ....................................................................................................................................................................22Takahisa Kondo ............................................................................................................................................................28, 42Takaki Hiwasa ..........................................................................................................................................................................17Takama Noriaki ......................................................................................................................................................................48Takashi Kawakami ...............................................................................................................................................................22Takayuki Jujo ...........................................................................................................................................................................17

Takehiro Igarashi...................................................................................................................................................................14Takeshi Kawakami ...............................................................................................................................................................45Takeuchi Kaori ...............................................................................................................................................................14, 43Takuwa Ayako .........................................................................................................................................................................40Tamada Naoki................................................................................................................................................................14, 46Tamura Yuichi ........................................................................................................................................................10, 28, 32Tan Ju Le ...........................................................................................................................................................26, 28, 43, 45Tanabe Nobuhiro ......................................................................................................................................17, 35, 46, 47Tanaka Hiroshi ........................................................................................................................................................................14Tanaka Mariko ........................................................................................................................................................................22Tanese Nikita ..................................................................................................31, 34, 35, 37, 40, 41, 42, 43, 48Taniguchi Yu .............................................................................................................................................................................46Tapson Victor F. ......................................................................................................................................................................12Taran Irina ..........................................................................................................................................................................35, 36Tatsumi Koichiro ................................................................................................................................17, 28, 35, 46, 47Tatsuo Aoki ................................................................................................................................................................................44Tatsuya Nishii ...........................................................................................................................................................................45Taylor Shalina ..........................................................................................................................................................................17Tcherakian Colas...................................................................................................................................................................18Tedford Ryan J. ......................................................................................................................................................................11Ten Freyhaus Henrik .................................................................................................................................................19, 40Teoh Jeremy....................................................................................................................................................................26, 28Tesson Laurent .......................................................................................................................................................................16Thakrar Mitesh ........................................................................................................................................................................33Thal Serge ..................................................................................................................................................................................19Thuillet Raphaël...................................................................................................................................................15, 18, 19Tian Xia .........................................................................................................................................................................................24Tielemans Birger ................................................................................................................................................18, 19, 45Tinazzi Elisa ...............................................................................................................................................................................49Titov Yevhen .............................................................................................................................................................................36Tocci Alejandro ......................................................................................................................................................................47Tomohisa Nakamura .........................................................................................................................................................36Tomotaka Nakayama ........................................................................................................................................................14Torbicki Adam .................................................................................................................................................................. 9, 45Torres Fernando .............................................................................................................................................................. 9, 36Torres Isabel .............................................................................................................................................................................47Toshihiko Sugiura ........................................................................................................................................................17, 43Toshihiro Sarashina .............................................................................................................................................................27Toshio Nakanishi...................................................................................................................................................................14Toshiro Shinke ...............................................................................................................................................................42, 45Toshner Mark R. ............................................................................................................................................................13, 21Toti Florence ............................................................................................................................................................................22Toumpourleka Maria ................................................................................................................................................26, 27Toyoaki Murohara .......................................................................................................................................................28, 42Toyoda Yoshiya ......................................................................................................................................................................47



67


Treacy Carmen M .................................................................................................................................................................21Trejo-Velasco Blanca ..........................................................................................................................................................41Trembath Richard C. ...........................................................................................................................................8, 13, 21Tresorier Romain ..................................................................................................................................................................21Tretyn Aleksandra ................................................................................................................................................................24Triantafyllidi Helen ..............................................................................................................................................................36Tsagkaris Hraklis ....................................................................................................................................................................36Tsagkaris Iraklis .............................................................................................................................................................35, 36Tsai Yi-Shan ...............................................................................................................................................................................30Tsang Yuen ................................................................................................................................................................................34Tsangaris Iraklis ...........................................................................................................................................19, 26, 27, 32Tsantes Argyrios ....................................................................................................................................................................19Tsioufis Konstantinos.........................................................................................................................................................31Tsubata Hideo .........................................................................................................................................................................46Tsuboi Yasunori .............................................................................................................................................................14, 46Tsugu Toshimitsu .........................................................................................................................................................24, 44Tsui Steven .................................................................................................................................................................................13Tsuji Akihiro ...............................................................................................................................................................................44Tsujino Ichizo ..................................................................................................................................................................29, 35Tsutomu Saji .............................................................................................................................................................................14Tsutsui Hiroyuki ......................................................................................................................................................................22Tu Ly ............................................................................................................................................................15, 18, 19, 28, 30Tufekcioglu Omac ......................................................................................................................................................46, 47Turner Stewart ........................................................................................................................................................................36Tyrka Anna .................................................................................................................................................................................36Tzifa Afroditi ..............................................................................................................................................................................31Uchida Shizuka ......................................................................................................................................................................19Ueda Jin.......................................................................................................................................................................................44Ulander Frida ...........................................................................................................................................................................16Ulrich Sylvia ....................................................................................................................................................16, 20, 32, 38Upton Paul D ............................................................................................................................................................................21Ushiki Atuhito ..........................................................................................................................................................................22Utako Yokoyama ...................................................................................................................................................................27Vachiéry Jean-Luc ............................................................................................................................11, 24, 32, 34, 40Vaidya Anjali ............................................................................................................................................................................47Valasarajan Chanil ...............................................................................................................................................................19Valieva Zarina ..........................................................................................................................................................................36Valkovicova Tatiana ..........................................................................................................................................25, 42, 44Valsarajan Chanil ..................................................................................................................................................................16Van Bezu Jan ...........................................................................................................................................................................18Van Duin Richard WB .....................................................................................................................................15, 23, 25Van Hulst Jennifer ................................................................................................................................................................23Van Loo Geert .........................................................................................................................................................................23Vantler Marius .........................................................................................................................................................................19Varela Brenda..........................................................................................................................................................................23

Varoudi Mary ...........................................................................................................................................................................36Varughese Rhea ....................................................................................................................................................................33Vasileios Grosomanidis ...................................................................................................................................................27Vasiliadis Konstantinos ....................................................................................................................................................31Vaughn Toby ............................................................................................................................................................................39Vazquez Haydee ...................................................................................................................................................................47Velchev Vasil ...................................................................................................................................................................31, 37Ventetuolo Corey .................................................................................................................................................................19Viethen Thomas ...........................................................................................................................................................31, 38Villa George ..............................................................................................................................................................................32Villarroel Ruth ..........................................................................................................................................................................40Vinhas Maria ............................................................................................................................................................................30Vinhas Maria Candida ......................................................................................................................................................16Vitola Barbara .........................................................................................................................................................................46Vizza Carmine Dario ..........................................................................................................................................................24Vocelle Matthieu ..........................................................................................................................................................13, 16Vonk Noordegraaf Anton ...................................................................................................9, 15, 17, 18, 21, 38Vrigkou Eleni ...........................................................................................................................................................................19Wada Yosuke ...........................................................................................................................................................................42Wade Rolin ................................................................................................................................................................................34Wagenaar Allard ................................................................................................................................................18, 19, 45Waisfisz Quintin ....................................................................................................................................................................21Waligóra Marcin ...........................................................................................................................................................36, 44Walsh Thomas ........................................................................................................................................................................19Walsworth Anna....................................................................................................................................................................13Wang Lingli ...............................................................................................................................................................................17Wang Mouer ............................................................................................................................................................................17Wargin William ......................................................................................................................................................................39Washko George ....................................................................................................................................................................24Watanabe Hiroshi ................................................................................................................................................................28Weatherald Jason ..............................................................................................................................................31, 33, 42Weber Christine ....................................................................................................................................................................20Weigert Andreas ..................................................................................................................................................................18Weinberg Isolde Maria ....................................................................................................................................................43Weirick Tyler .............................................................................................................................................................................19Weiß Astrid ...............................................................................................................................................................................24Weissmann Norbert.........................................................................................................................................11, 16, 24Wells Athol U ...........................................................................................................................................................................37Wen Sewa Du .........................................................................................................................................................................26Werner Astrid ..........................................................................................................................................................................19Wharton John .........................................................................................................................................................................21Whitaker Wolf Plínio José .............................................................................................................................................28Whitehorn Deborah ..........................................................................................................................................................21Whittle Brendan ....................................................................................................................................................................37Wiedenroth Christoph .....................................................................................................................................................43



68


Wietelmann Astrid ..............................................................................................................................................................16Wikström Gerhard ..............................................................................................................................................................16Wilhelm Jochen ....................................................................................................................................................................43Wilkins Martin R. .................................................................................................................................................10, 13, 21Williams Paul ................................................................................................................................................................................9Williams Rex .............................................................................................................................................................................39Williams Trevor ..............................................................................................................................................................40, 42Winkler Tilo ...............................................................................................................................................................................24Wirtz Hubert .............................................................................................................................................................................32Wojciech Magon ..................................................................................................................................................................33Wolf Janine ...............................................................................................................................................................................18Wolf Matthias ..........................................................................................................................................................................29Woller Scott ..............................................................................................................................................................................43Wong Brad A. ..........................................................................................................................................................................12Wong Maggie ...............................................................................................................................................................26, 28Wort Stephen J .............................................................................................................................................................21, 26Wort Stephen John ............................................................................................................................................................13Wuyts Wim ................................................................................................................................................................................37X C Fonseca Angelo ..........................................................................................................................................................23Xavier Jais ..................................................................................................................................................................................39Yakut Idris ...................................................................................................................................................................................46Yamamoto Hiroshi...............................................................................................................................................................22Yamamoto Keiko ..................................................................................................................................................................47Yamauchi-Takihara Keiko ...............................................................................................................................................40Yanaka Ken-Ichi .....................................................................................................................................................................46Yanaka Kenichi ..............................................................................................................................................................14, 46Yang Jung Hoon ...................................................................................................................................................................28Yaoita Nobuhiro ..................................................................................................................................................17, 25, 39Yap Jonathan ................................................................................................................................................26, 28, 43, 45Yasuda Satoshi .......................................................................................................................................................................44Yasuda Shinsuke ..........................................................................................................................................................29, 35Yasunori Tuboi ........................................................................................................................................................................45Yasuo Masanori .....................................................................................................................................................................22Yasuo Ono .................................................................................................................................................................................14Yates Katherine ......................................................................................................................................................................21Yaylali Yalin Tolga ...............................................................................................................................................41, 42, 47Yerabolu Naga Dinesh Reddy ...................................................................................................................................19Yilancioglu Resit Yigit........................................................................................................................................................31Yildizeli Bedrettin .................................................................................................................................................................44Yilmaz Samet ...........................................................................................................................................................................47Yohei Shigeta ..........................................................................................................................................................................14Yoichi Sugiyama ....................................................................................................................................................................36Yoichiro Matsuoka ...............................................................................................................................................................42Yoon Hyun Ju ..........................................................................................................................................................................44Yoshiaki Kitaguchi ...............................................................................................................................................................42

Yoshihide Mitani ...................................................................................................................................................................14Yoshihiro Fukumoto ...........................................................................................................................................................36Yoshihiro Kamimura..................................................................................................................................................28, 42Yoshihisa Nakano........................................................................................................................................................28, 42Yoshino Hideaki ...........................................................................................................................................................14, 43Yoshiya Toyoda ......................................................................................................................................................................47Yu Chang ....................................................................................................................................................................................20Yuasa Shinsuke ......................................................................................................................................................................44Yuichi Tamura ..........................................................................................................................................................................15Yuichiro Fujieda .....................................................................................................................................................................35Yuji Itabashi ......................................................................................................................................................................22, 45Yuki Aimi .....................................................................................................................................................................................22Yuto Shinkura .................................................................................................................................................................42, 45Yuu Izawa ....................................................................................................................................................................................45Zamanian Roham .................................................................................................................................................................10Zanaboni Jacopo .................................................................................................................................................................16Zehendner Christoph .......................................................................................................................................................19Zeiher Andreas ......................................................................................................................................................................19Zhao Carol .................................................................................................................................................................................38Zhao Zhixin ...............................................................................................................................................................................17Zhyvylo Iryna ...................................................................................................................................................................28, 36Zuffa Elisa ...................................................................................................................31, 34, 35, 37, 41, 42, 43, 48



69

SPONSORS



70

NOTES



71

NOTES

The Symposium Secretariat

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