Workshop on Standards for Workshop on Standards for EHS Research Needs for EHS Research Needs for Engineered Nanoscale Engineered Nanoscale

MaterialsMaterials

WELCOMEWELCOME

Workshop on Standards for Workshop on Standards for EHS Research Needs for EHS Research Needs for Engineered Nanoscale Engineered Nanoscale

MaterialsMaterials

WELCOMEWELCOME

Chemical Science and Technology Chemical Science and Technology Laboratory Laboratory

NISTNIST

Gaithersburg, MD USAGaithersburg, MD USASeptember 12-13, 2007September 12-13, 2007

Chemical Science and Technology Chemical Science and Technology Laboratory Laboratory

NISTNIST

Gaithersburg, MD USAGaithersburg, MD USASeptember 12-13, 2007September 12-13, 2007

www.nist.govwww.nano.gov

emergency number, x 2222

Bldg. 215: Advanced Measurement Laboratory

ExitsExits

MenMenMenMen

H103H105

WomenWomenWomenWomen

A019

H107

Conference Room

Evacuation Assembly Location

The Organizing Committee Welcomes YouStandards for Nano-EHSStandards for Nano-EHS

Name Affiliation

Nora Savage U.S. EPA

Justin Teeguarden Pacific Northwest National Laboratory

Dianne Poster NIST

John Small (Chair) NIST

Nigel Walker NIEHS

Scott McNeil NCL

Richard Canady U.S. FDA

Laurie Locascio NIST

Vladimir Murashov NIOSH

Cate Alexander Brennan NNCO

Mark Wiesner Duke University

Michael Postek NIST

Eric Amis NIST

Kalman Migler NIST

David Warheit Dupont

Vicki Colvin Rice University/ICON

Angie Hight Walker NIST

Debbie Kaiser NIST

Standards for Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials

Sponsors:

NIST (www.nist.gov)

National Nanotechnology Initiative (www.nano.gov)

Purpose:

To identify standard materials needed to address toxicology and risk assessments of engineered nanoscale materials and technical challenges

Standards for Nano-EHSStandards for Nano-EHS

Goals are to:1. Develop Approaches for Identifying Standard Materials

Critical for Risk Assessment and Risk Management

2. Nomination of Materials Specific to User and Community Needs

3. Identify Critical Materials Characterization Parameters Required to Meet Needs of Specific Users and Communities

4. Identify Priority Reference Materials, Characterizations and Time-scales for Development

Products will include an official NNI report to:

assist with developing standards to address toxicology and risk assessments of engineered nanoscale materials

recommend priority materials

enable investment in the development of such materials

Standards for Nano-EHSStandards for Nano-EHS

Standard Reference Materials (SRMs)

• certified reference materials issued by NIST

• homogeneous, stable materials well-characterized for one or more chemical and/or physical properties

• assist laboratories worldwide in validating analytical measurements of chemical or physical composition

• range of compounds and physical characteristics for particle-related materials• Hear about these tomorrow from

Debbie Kaiser

Logistics

breakfast and lunch provided here

working dinner tonight: bus leaves lobby entrance at 1730

Facilitation: Energetics Inc. Joan Pellegrino, Melissa Eichner, Matt Antes, Katie Jereza, Lindsay

Pack, Pamela de los Reyes, Howard Andres

Technical Leads, Facilitators and Scribes present in the breakouts:

Group A: Cross Cut Issues in Development of Standard Materials

Group B: Materials for Occupational Exposure

Group C: Materials for Environmental Fate and Transport

Group D: Materials for Human & Ecological Health

Rooms here and down the hall on left, signs on the doors

Technical Leads and writing team on Friday

Please sign up if here on Friday, writing team additions also sign

Standards for Nano-EHSStandards for Nano-EHS

Group A: Cross Cut Issues in Development of Standard Materials: Areas that impact multiple users and communities

challenges in material considerations, experimental methods, production (sources, volumes); time scales or cost

policy, international standards cooperation

interagency collaboration, coordination; inter-laboratory comparisons Rick Canady (Session I), Dianne Poster (Session II/III), Mike Goreman and

Wyatt Vreeland (Session IV)

Group B: Materials for Occupational Exposure Reference materials for risk assessment, risk management, and

characterization of nanoparticle exposure in the workplace

materials for inhalation, ingestion, skin absorption, other routes

materials to support international consensus standards for nanoparticle exposure

Vladimir Murashov (Session I), Mark Hoover (Sessions II/IV), David Warheit (Session III)

Standards for Nano-EHSStandards for Nano-EHS

Group C: Materials for Environmental Fate and Transport

assess environmental exposure to nanomaterials in air, water and soil

determine fate and transport once released into the environment

understand their subsequent behavior and fate

mixing, dispersing, concentrating, agglomerating, decomposing, reacting, transformations

John Small (Session I), Greg Lowry (Session II), Joel Pedersen (Session III), Pratim Biswas (Session IV)

Group D: Materials for Human & Ecological Health

assessment of the biological response to engineered nanoscale

materials via environmental or non-incidental exposure to humans and

other living systems (aquatic, plants, animals)

understand effects on subcellular components, cells, tissues, organs,

organ systems, and whole organisms (e.g., bioaccumulation, toxicity) Justin Teeguarden (Session I), Vicki Colvin (Session II), Stephen Klaine

(Session III), Nigel Walker (Session IV)

Standards for Nano-EHSStandards for Nano-EHS

8:35 am – 12:00 pm Session I: Approaches for Identifying Standard Materials Critical for Risk Assessment and Risk Management

8:35 am: Considerations for Selecting Materials for Understanding Risks of Nanomaterials

- What is Necessary? Justin Teeguarden, Pacific Northwest National Laboratory

9:00 am: Considerations for Selecting Standard Materials for Occupational Safety and

Health Vladimir Murashov, National Institute for Occupational Health and Safety

9:25 am: Considerations for Nanomaterials in Environmental Fate and Transport

Assessment Mark Wiesner, Duke University

9:50 am BREAK

10:05 am International Council on Nanotechnology (ICON) – Nanotechnology EH&S

Research Needs Assessment toward Nanomaterial Classes Vicki Colvin, Rice University

10:30 am An Overview of REFNANO: A UK Initiative on Reference Materials for

Engineered Nanoparticle Toxicology and Metrology Steven M. Hankin, Institute of

Occupational Medicine, Edinburgh UK

10:50 am Group Discussion: Approaches to identifying standard materials (key considerations, criteria)

12:00 pm LUNCH

Standards for Nano-EHS- This MorningStandards for Nano-EHS- This Morning