wnt/β-catenin pathway seminar spring 2011 maneeshi prasad 21st jan 2011 man
TRANSCRIPT
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Wnt/β-catenin pathway
Seminar Spring 2011
Maneeshi Prasad21st Jan 2011
Man
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Wnt pathway
• Ligands
• Receptors
• Intracellular components
• Transcription factors
• Interactome
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Wnt
• “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes
• Wnt are secreted proteins
• 19 Wnt genes in humans and mice
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Wnt Receptors
• Receptor tyrosine kinase
• Derailed/RYK
• ROR
• Frizzled-transmembrane receptor
• LRP (lipoprotein-receptor related protein)
• Single-pass Tm proteins
• Cytoplasmic tail phosphorylated by GSK3 and CK1γ
http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams
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Wnt Pathway
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Wnt signaling
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Interactions: Intracellular Components
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Intracellular Components
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Canonical/Non-canonical Wnt pathway
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Wnt Pathway Interactome
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Wnt pathway interactions
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Role of Wnt signaling
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Role of Wnt signaling
• Development
• Neural development: CNS
• Neural crest
• Limb
• Tumor formation
• Cellular growth and proliferation