What is asthma?

What is COPD?

COPD Chronic obstructive pulmonary disease (COPD), also known as chronic

obstructive airway disease (COAD), is a group of diseases characterised by limitation of airflow in the airway that is not fully reversible. COPD is the umbrella term for chronic bronchitis and/or emphysema. It is most often due to tobacco smoking [1] but can be due to other airborne irritants such as coal dust or solvents.

Chronic BronchitisChronic bronchitis is defined in clinical terms as a cough with sputum production on most days for 3 months of a year, for 2 consecutive years.[6]Chronic bronchitis is hallmarked by the increased number (hyperplasia) and increased size (hypertrophy) of the mucus-secreting (goblet) cells of the airway. This, along with enlargement of the mucous gland, results in an increase in production of mucus which contributes to the airway obstruction. Microscopically there is infiltration of the airway walls with inflammatory cells, particularly neutrophils. Inflammation is followed by scarring and remodelling that thickens the walls resulting in narrowing of the small airway. Further progression leads to an abnormal change (metaplasia) in the nature of the tissue along with further thickening and scarring (fibrosis) of the lower airway. The consequence of these changes is a limitation of airflow. [7]EmphysemaMain article: EmphysemaEmphysema is defined histologically as the enlargement of the air spaces distal to the terminal bronchioles, with destruction of their walls.[6]The enlarged air sacs (alveoli) of the lungs reduces the surface area available for the movement of gases during respiration. This can cause breathlessness in severe cases. The exact mechanism for the development of emphysema is not understood, although it it known to be linked with smoking and age.

Historically, what therapeutic agents have been used? Ephedrine, as part of the Chinese medicine Ma Huang, has been used in the treatment of respiratory diseases for over 5000 years

Ephedrine is now known to act indirectly, by releasing endogenous catecholamines, resulting in bronchodilation

In 1900, Solis-Cohen showed that orally administered adrenal extract was beneficial in asthma.

Historic

Initially, subcutaneous injections of epinephrine were used, followed by a nebulized epinephrine solution.

Epinephrine is one of the most potent vasopressor (i.e. causes constriction of the blood vessels and corresponding rise in blood pressure) drugs known.

Epinephrine affects respiration primarily by relaxing the bronchial muscle.

Epinephrine is rapidly metabolized by COMT, primarily in the liver.

Can we make an asthma drug with less side effects, and longer lasting?

Clues: It is known that the 2 receptor is the target for

relaxation of bronchial smooth muscle. Epinephrine has approx. equal affinity for both

and receptors However norepinephrine has greater affinity for

the receptors This indicates that placing an alkyl group on the

nitrogen leads to an increase in selectivity for the -receptors.

HO

HO

NHMe

OH

Epinephrine(Adrenaline)

HO

HO

NH2

OH

Norepinephrine(Noradrenaline)

Greater selectivity for receptors

Equal selectivity forBoth and -receptors

Perhaps, still greater selectivity for -receptors could beGenerated by appending larger alkyl substituent on nitrogen

An improvement!

Isoprenaline was synthesized by German chemists in the 1940’s

It had less cardiovacular side effects than adrenaline

Became the most widely used inhaled treatment for asthma for the next 20 years.

HO

HO

HN

OH

Isoprenaline

Further improvements needed

Needed an agent which was longer lasting, more resistant to COMT

Needed an agent which was more selective for the 2 receptors in the lung and less selective for the 1 receptors of heart.

Arrives Salbutamol

Tert-butyl group renders salbutamol more selective for 2

Hydroxymethyl group (in place of OH) renders salbutamol resistant to COMT

Remains the most widely used anti-asthma drug in the world

HOCH2

HO

HN

OH

Salbutamol

Salbutamol

Salbutamol (INN) or albuterol (USAN) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD.Salbutamol sulphate is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebuliser or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the effect of Salbutamol can take place within 5 to 20 minutes of dosing. Salbutamol can also be given orally or intravenously. However, some asthmatics may not respond to these medications as they will not have the required DNA base sequence in a specific gene.Salbutamol became available in the United Kingdom in 1969 and in the United States in 1980 under the trade name Ventolin.

HOCH2

HO

HN

OH

Salmeterol

O

Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD. It is currently available in both dry-powder inhalers (DPIs) and pressurised metered dose inhalers (pMDIs).

It is a long acting beta-adrenoceptor agonist (LABA), usually only prescribed for severe persistent asthma following previous treatment with a short-acting beta agonist such as salbutamol and is prescribed concurrently with a corticosteroid, such as beclometasone. The primary noticeable difference of salmeterol to salbutamol is that the duration of action lasts approximately 12 hours in comparison with 4 ﾐ6 hours of salbutamol.

BRONCHODILATORS, ADRENERGIC

(Inhalation)*

In the U.S-.

Adrenalin Chloride 3Airet 1

Alupent 8Arm-a-Med Isoetharine 6

Arm-a-Med Metaproterenol 8

Asthmahaler Mist 3AsthmaNefrin 3

Beta-2 6Brethaire 12

Bronkaid Mist 3Bronkaid Suspension Mist

3Bronkometer 6

Bronkosol 6Dey-Lute Isoetharine 6

Dey-Lute Metaproterenol 8Foradil 5Isuprel 7

Isuprel Mistometer 7Maxair 9

Maxair Autohaler 9Medihaler-Iso 7

microNefrin 3Nephron 3

Primatene Mist 3Proventil 1

Proventil HFA 1S-2 3

Serevent Diskus 11Vaponefrin 3

Ventolin 1Ventolin HFA 1

Ventolin Nebules 1Ventolin Rotacaps 1tolin

Rotacaps 1

In Canada-

Alupent 8Apo-Salvent 1

Berotec 4Bricanyl Turbuhaler 12Bronkaid Mistometer 3

Foradil 5Gen-Salbutamol Sterinebs

P.F. 1Isuprel 7

Isuprel Mistometer 7Maxair 9

Novo-Salmol 1Oxeze Turbuhaler 5

Pro-Air 10Serevent 11

Serevent Diskhaler 11Serevent Diskus 11

Vaponefrin 3Ventodisk 1

Ventolin 1Ventolin Nebules P.F. 1Ventolin Rotacaps 1tolin

Rotacaps 1

This information applies to the following medicines:1.Albuterol (al-BYOO-ter-ole)‡§2.Bitolterol (bye-TOLE-ter-ole)*†3.Epinephrine (ep-i-NEF-rin)‡4.Fenoterol (fen-OH-ter-ole)*5.Formoterol (for-MOH-ter-ol))‡§6.Isoetharine (eye-soe-ETH-a-reen)†‡7.Isoproterenol (eye-soe-proe-TER-e-nole)‡8.Metaproterenol (met-a-proe-TER-e-nole)‡9.Pirbuterol (peer-BYOO-ter-ole)10.Procaterol (proe-KAY-ter-ole)*11.Salmeterol# (sal-ME-te-role)*12.Terbutaline (ter-BYOO-ta-leen)