what does the neurootologist need to know about eye movements? · what does the neurootologist need...
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What does the neurootologist need to know about eye movements?
1) Functional classification of eye movement subtypes2) How to examine at the bedside the different eye movement
subtypes3) Localization using eye movement abnormalities in classical
syndromes that may present to the neurootologist1) Syndromes of the posterior fossa
1) Wallenbergs2) AICA3) INO4) Cerebellum
1) FLOCCULUS2) NODULUS
2) Distinctive syndromes that present to the Neurootologist1) OPSOCLONUS2) PSP (Progressive Supranuclear Palsy3) WERNICKES4) UPBEAT NYSTAGMUS
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The dominance of the fovea
•Courtesy, Chris Kennard•G Westheimer
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•Serve the needs of vision, and specifically those of the fovea where spatial acuity is best.
Function and classification of eye movements
•Bring images onto the fovea (saccades and vergence)
•Keep images still on the fovea, for best spatial resolution (vestibular, pursuit and vergence)
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Skew deviation, ptosis, head tilt Wallenbergs
•Learn to do a simple alternative cover test
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Saccadic dysmetria – overshoot to one side, undershoot to the other
WALLENBERG’S SYNDROME
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Wallenberg’s Syndrome – PICA distribution infarctinvolving the dorsolateral medulla
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Wallenberg’s Syndrome – PICA distribution infarctinvolving the dorsolateral medulla
Restiform body (ICP)
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Wallenberg’s syndrome (PICA)
• Skew deviation (OTR), due to involvement of caudal vestibular nuclei mediating otolith-ocular responses
• Saccadic dysmetria (ipsipulsion) due to a functional lesion of the fastigial nucleus from interruption of olivary-cerebellar climbing fibers to the cerebellar cortex which increases Purkinje cell inhibition on underlying fastigial nucleus.
• REMEMBER distal (medial) PICA syndrome which can mimic an acute vestibular neuritis.
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VOR head impulse sign in a patient with hearing loss, facial weakness and limb
ataxia
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Middle cerebellar peduncle lesion in AICA infarct
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AICA syndrome
• Peripheral involvement: Internal Auditory Artery: Unilateral loss of vestibular function– Skew deviation (OTR), due to involvement of otolith-
ocular responses– Impulse sign due to involvement of canal-ocular
responses– Hearing loss
• Central involvement: Ataxia, due to involvement of cerebellar pathways. Other signs of lateral pons
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Internuclear ophthalmoplegia (INO) with adduction failure and abducting nystagmus and spared adduction with convergence
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INO Skew deviation and head tilt
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MLF lesion
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MLF syndrome (INO)
• Slowing or loss of (conjugate) ADduction of eye on side of lesion with sparing of vergence-mediated adduction.
• Contralateral eye nystagmus on ABduction• OTR due to involvement of otolith-ocular
pathways traveling in the lateral portion of the MLF.
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Downbeat, gaze- evoked and rebound nystagmus in cerebellar atrophy
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Pursuit and VOR Cancellation abnormalities in cerebellar atrophy
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Cerebellar flocculus and paraflocculus (tonsils)
Flocculus
Paraflocculus
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Abnormal VOR in cerebellar diseaseAbnormal direction
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Head-shaking nystagmus in cerebellar disease downbeat after horizontal head shaking
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Cerebellar floccular-parafloccular (tonsil) syndrome
• Gaze-evoked, rebound, downbeat nystagmus
• Loss of pursuit and cancellation of the VOR during combined eye-head tracking
• Abnormal ‘cross-coupling’ with vertical responses to horizontal stimulus
• Postsaccadic drift
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Periodic Alternating Nystagmus (PAN)
Null every two minutes
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Anatomical Locus of PAN
Nodulus
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PAN: Pathogenesis and Treatment
• Two key normal mechanisms– Central velocity-storage mechanism located within the
vestibular nuclei that improves the ability of the vestibular system to respond to low-frequency head motion by perseverating peripheral vestibular signals.
– Adaptation mechanism that acts to null any sustained unidirectional nystagmus (which in natural circumstances is always due to a lesion)
• In PAN, instability in velocity storage is produced by loss of (gaba-mediated) inhibition from the Purkinje cells of the nodulus onto the vestibular nuclei.
• Short-term adaptation (which is working normally) causes reversals of nystagmus leading to sustained oscillation.
• Baclofen (GABA-b) provides the missing inhibition and stops the nystagmus.
– Usually need only 10 mg PO TID.– Avoid precipitous discontinuation.– Memantine may be a useful adjunct– Medications do not work as well in congenital PAN.
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Opsoclonus
Patient with a few days of vertigo then objects began jumping
Causes
Paraneoplastic
Metabolic-toxic
Post viral, immune mediated
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Some normal subjects can voluntarily produce saccadic oscillations (this capability can run in
families)
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Progressive loss of balance with falls
PROGRESSIVE SUPRANUCLEAR PALSY (PSP) Slow vertical saccades, saccadic intrusions
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MRI in PSP
PSP small midbrain, ‘humming bird’ or ‘penguin’ sign
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Anatomical locus for vertical saccade commands
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Top of the Basilar Syndromesupranuclear vertical gaze palsy
predominantly down
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Vertical (down) gaze problemsLesions in riMLF and caudal thalamus
Artery of Pecheron (subthalamic perforator from the posterior cerebral artery)
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Recent onset of jumping vision and imbalance
Wernicke’s syndrome (B1-thiamine)
Bariatric surgery
Chemotherapy
Alcoholism
Eating disorders
Hypermesis Gravidarum
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Wernicke’s Disease – Absent VOR slow phases (acute horizontal bilateral vestibulopathy (Choi l)
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Wernicke’s Disease(lesions in the medial vestibular nuclei)
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Upbeat nystagmus
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Minagar et al. Neurology 2001
Pierrot-Deseilligny and Milea, Brain, 2005
Upbeat nystagmus and the nucleus intercalatus and nucleus of Roller (perihypoglossal nuclei).
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A Phone Call from an Acutely Vertiginous Patient: Key Diagnoses
Stroke BPPV
Headache,Neck painOther Neurological Symptoms (diplopia, numbness, weakness, hiccoughs, dysphagia, dysarthria, incoordination),Hearing loss,Risk Factors (age, hypertension, lipid disorder, heart disease, diabetes)
Aural symptoms (pain, pressure, fullness in ear, seashell tinnitus, hearing loss (low frequency, fluctuating)
Headache, Family or personal history of migraine, Triggers, Aura, Light sensitivity, Relieved by sleep
Vestibular Neuritis
Vestibular Migraine
Menieres
Positional, Transient,Recent inciting events (dentist, hair dresser, trauma)
Sustained vertigo even when at rest though worsened by movement,Viral illness
Neurological symptoms?Headache or neck pain?Any previous episodes?Duration of the spell?Is it positional?Hearing symptoms?Age?Vascular risk factors?
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The Acutely Vertiginous Patient: Key Findings
Stroke BPPV
Spontaneous jerk nystagmus that does not suppress with fixation,Gaze-evoked, direction -changing nystagmus, Skew deviation,Absent head impulse sign (though if present does not r/o stroke)Other neurological signs
Spontaneous nystagmus similar to vestibular neuritis,Nystagmus may spontaneously change direction in the first hours after onset.Loss of hearing,
May mimic BPPV or Vestibular Neuritis or have central ocular motor signs (gaze-evoked or vertical nystagmus)
Vestibular Neuritis
Vestibular Migraine
Menieres
Positional nystagmus,Transient, after a latency,usually mixed vertical torsional if posterior canal or horizontal if lateral canal BPosterior canal BPPV changes direction on sitting up
Sustained, spontaneous mixed horizontal-torsional nystagmus in straight ahead gaze.Obeys Alexander’s law (more intense with gaze in the direction of quick phase)More intense when lying with bad ear down.Suppressed with fixation,Positive head impulse sign
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A Flow Chart For Classification Of NystagmusIs fixation impaired because of a slow drift, or an intrusive saccade, away from the fixation target?
If a slow drift is culprit
Jerk Pendular
Unidrectional
Changes direction with viewing eye = Latent Nystagmus
Vestibular (constant velocity)
Central Peripheral
Acquired (MS or OPT) or Congenital
Changes direction with direction of gaze (gaze-evoked)
Congenital (velocity increasing)
Acquired(velocity decreasing e.g. cerebellar)
(Use effect of fixation and vector of nystagmus)