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    CLINICAL NUTRITION MANAGEMENT

    OFSUPERIOR MESENTERIC ARTERY

    THROMBOSIS

    Dana Magee

    ARAMARK Distance Dietetic Internship

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    OVERVIEW

    Disease Description

    Evidenced Based Nutrition Recommendations

    Case Presentation

    Nutrition Care Process

    Assessment

    Nutrition Diagnosis

    Interventions

    Monitoring and Evaluation

    Conclusion

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    ACUTE MESENTERIC ISCHEMIA

    (AMI)

    Inadequate blood flow to the bowel caused by:

    Non- occlusive Mesenteric Ischemia (NOMI)

    Mesenteric Vein Thrombosis (MVT)

    Acute Mesenteric Atrial (AMA) Embolus

    Acute Mesenteric Atrial (AMA) Thrombosis

    http://emedicine.medscape.com/article/191560

    -overview#showall

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    OCCLUSIVE MESENTERIC

    ISCHEMIAEmbolus Thrombosis

    50% of AMI cases 25% of AMI cases

    Occurs in distal branches Occur at origin of SMA

    Quick onset Gradual onset

    Low collateral blood flow Larger portion of bowelaffected

    Smaller portion of bowel

    affected

    Can affect multiple arteries

    Associated with MI, mitral

    stenosis, Afib, endocarditis,mycotic aneurysm,

    dislodged plaque

    Associated with CAD,

    stroke, PAD, dehydration,MI, HF

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    ACUTE MESENTERIC ISCHEMIA

    Risks for AMI

    Age over 50 years old

    Atherosclerosis (African Americans as higher risk)

    AFib

    Hypercoaguable states (Critical Care)

    Epidemiology

    AMI accounts for .1% of hospital admissions in US

    Mortality rate is 71% (AMA thrombosis is highest mortalityrate)

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    SIGNS AND SYMPTOMS

    Abdominal pain out of proportion to expectation

    Benign abdominal exams

    Fear of eating due to postprandial pain

    N,V, D

    GI bleed

    Bad breath

    AFib

    Signs of sepsis

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    SMA BLOCKAGE

    Ischemia can lead to:

    Vomiting and diarrhea

    GI bleed

    Necrotic bowel (8-12 hrs)

    Bacterial overgrowth

    Perforated bowel

    Sepsis

    HF

    Multi- organ system failure

    http://emedicine.medscape.com/article/191560-

    overview#showall

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    DIAGNOSIS

    Aortography gold standard

    Distinguish between SMA thrombosis and embolism

    CT scan / ultrasound

    Not as specific or sensitive Can see blockage of SMA

    Can rule out other reasons for abdominal pain

    Lab results helpful- not for diagnosis

    CBC, PPT, acid base balance, lactate

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    TREATMENT

    Immediate exploratory surgery

    Remove ischemic/ necrotic bowel

    Embolectomy

    In surgery: Peristalsis

    Coloring

    Doppler ultrasonography

    IV fluorescent under Woodlamp

    Second look surgery

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    CASE PRESENTATION

    Presented with abdominal pain out of proportion

    Admitting diagnosis: SMA thrombosis

    PMH: A-Fib, stroke, CAD, HTN, cardiomyopathy.

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    http://web.uni-plovdiv.bg/stu1104541018/docs/res/skandalakis'%20surgical%20anatomy%20-

    %202004/Chapter%2018_%20Large%20Intestine%20and%20Anorectum.htm

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    CASE PRESENTATION

    CT scan showed SMA thrombosis

    Started on TPN

    Exploratory laparotomy

    30 cm small bowel resected, NGT decompressionSecond look surgery

    GI bleed

    Pacemaker

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    EVIDENCED BASED GUIDELINES

    Early or late parenteral nutrition: ASPEN vs. ESPEN

    Casaer MP, Mesotten D, Hermans G et al

    Objective: Comparing the early initiation of PN (European)

    vs. late initiation of PN (American and Canadian)

    Prospective, randomized, controlled, parallel- group,

    multicenter trial in Belgium

    Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. New England Journal of Medicine. 2011; 365 (6): 506-517.

    Doi: 10.1056/NEJMoa1102662.

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    EVIDENCED BASED GUIDELINES

    Protocol:

    2312 patients receiving PN in 48 hours

    2328 patients receiving PN after seven days

    Patients must be at nutritional risk

    Excluded patients with BMI

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    EVIDENCED BASED GUIDELINES

    PN 48 hours post admission ICU

    1 day shorter LOS in ICU (p

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    EVIDENCE BASED GUIDELINES

    Conclusion: Late initiation better outcomes for patients.

    Limitations:

    No glutamine in PN or other modulators

    Premixed PN

    No indirect calorimetry

    Not double blinded study

    Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. New England Journal of Medicine. 2011; 365 (6): 506-517.

    Doi: 10.1056/NEJMoa1102662.

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    EVIDENCE BASED GUIDELINES

    ASPEN: Adult Critical Care Guidelines:

    Early PN feeding with protein calorie malnutrition

    Indicated with recent weight loss of 10-15%

    Studies show:

    Lower risk for complications (p

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    EVIDENCE BASED GUIDELINES

    Efficacy of Parenteral Nutrition Supplemented with Glutamine

    Dipeptide to decrease Hospital Infections in Critically Ill Surgical

    Patients

    Estivariz CF, Griffith DP, Luo M, et al

    Double blind, randomized, controlled study Objective: Effect of glutamine PN (GLN-PN) vs. standard PN

    (STD-PN) on infections in critically ill surgery patients

    Estivariz CF, Griffith DP, Luo M, et al. Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in

    critically ill surgical patients. Journal of Parenteral and Enteral Nutrition. 2008; 32 (4): 389-402. doi: 10.1177/0148607108317880.

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    EVIDENCE BASED GUIDELINES

    Methods:

    2 Cohorts: pancreatic necrosis surgery and

    cardiac/vascular/colonic surgery

    Ages 18-80

    s/p one of five surgeries

    Required PN for at least 7 days

    Estivariz CF, Griffith DP, Luo M, et al. Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in

    critically ill surgical patients. Journal of Parenteral and Enteral Nutrition. 2008; 32 (4): 389-402. doi: 10.1177/0148607108317880.

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    EVIDENCE BASED GUIDELINES

    GLN- PN

    30 subjects

    0.5 g/kg/day glutamine

    with 1 g/kg/day amino

    acid solution

    STD- PN

    29 subjects

    1.5 g/kg/day amino acid

    solution

    Estivariz CF, Griffith DP, Luo M, et al. Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in

    critically ill surgical patients. Journal of Parenteral and Enteral Nutrition. 2008; 32 (4): 389-402. doi: 10.1177/0148607108317880.

    Limitations:

    Availability of glutamine- two time periods of

    research

    Limited number of postoperative PN

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    EVIDENCE BASED GUIDELINES

    No significant changes in infection in the pancreatic cohort

    In non- pancreatic cohort GLN- PN

    Decrease in total infections (p

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    EVIDENCE BASED GUIDELINES

    Critical Illness Nutrition Practice Guidelines 2012

    Recommend glutamine considered in treatment for critically ill

    Associated with decreased risk of infection

    Not sufficient evidence for decreased LOS, intubation

    period, medical cost, or mortality

    Academy of Nutrition and Dietetics. Recommendations Summary CIU: Supplemental Glutamine. Evidence Analysis Library.

    http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201. Accessed March 22, 2013.

    http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201
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    EVIDENCE BASED GUIDELINES

    Aspen Adult Critical Care Guidelines

    Recommend 0.5 g/kg/day glutamine in PN

    Associated with decreased risk of infection, LOS, and mortality

    McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the Provision and Assessment of Nutrition Therapy in Adult Critically

    Ill Patient. Journal of Parenteral and Enteral Nutrition. 2009; 33 (3): 285-290. Doi: 10.1177/0148607109335234.

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    NUTRITION CARE PROCESS

    Assessment: Client History

    A-Fib uncontrolled

    Does not work

    Lives at home with a caregiver

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    NUTRITION CARE PROCESS

    Assessment: Food/Nutrition-Related History:

    Poor appetite after stroke, 40 pound weight loss

    Patient reported 11 pound weight loss in one week

    PTA following a low fat diet

    Assessment: Nutrition-Focused Physical Findings:

    Nausea and vomiting X two days

    Abdominal pain out of proportion to expectation

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    NUTRITION CARE PROCESS

    Assessment: Anthropometric Measurements

    Height discrepancies 62-71 inches

    Weight 145 pounds

    BMI 22.79

    Usual weight 156 pounds

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    NUTRITION CARE PROCESS

    Assessment: Nutrient Needs

    Energy: 1650-1848 kcal

    (25-28 kcal/kg actual body weight)

    Protein 79-99g protein

    (1.2-1.5g/kg actual body weight)

    Fluid needs: 1680-1890 ml

    (25-30 ml/kg actual body weight)

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    NUTRITION CARE PROCESS

    Assessment: ARAMARK Nutrition Status Classification

    Nutrition Care Indicator Category

    Highest Points Assigned

    Nutrition History 3 (poor appetite and vomiting)

    Feeding Modality/Nutrition Care Order

    4 (anticipated TPN)

    Unintentional Weight Loss 4 (greater than 2% weight loss in one

    week)

    Weight Status 0

    *Serum Albumin or Pre-albumin

    0

    Dx/Condition 3 (anticipated GI surgery)

    TOTAL POINTS 14 Nutritionally severely compromised

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    NUTRITION CARE PROCESS

    DRG Coding

    Weight loss of 5-10% of usual body weight

    Albumin 3.5-5

    Mild Protein calorie malnutrition

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    NUTRITION CARE PROCESS

    Nutrition Diagnosis

    Inadequate oral intake related to GI distress as evidenced by

    NPO diet order, 0% intake and not meeting estimated kcal or

    protein needs.

    Inadequate parenteral infusion related to parenteral prescriptiondoes not meet estimated nutritional needs as evidenced by

    parenteral regimen providing 67% of estimated caloric needs.

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    NUTRITION CARE PROCESS

    Interventions

    Once PICC is functional initiate day one TPN. 1700 ml volume:

    70g protein, 150g CHO, 15g lipid.

    Day two recommend 1700 ml volume: 80g protein, 255g CHO,

    and 15g lipids to provide 1337 kcal, 80g protein, GIR 2.68 (81% ofnutritional needs)

    Increase CHO in TPN to 255g.

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    NUTRITION CARE PROCESS

    Monitoring and evaluation

    Food and nutrient intake: Parenteral nutrition administration

    Monitor parenteral access

    Food and nutrient administration: Parenteral nutrition intake

    formula/ solutionAnthropometric Measurements: Body weight

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    MONITORING AND EVALUATION

    Biochemical data, medical tests, and procedures: Electrolytes

    and renal profile potassium, magnesium, and phosphorus

    Biochemical data, medical tests, and procedures: glucose

    endocrine profile, glucose casual

    Nutrition- focused physical findings: Digestive system: returnof GI function.

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    CONCLUSION

    SMA thrombosis, NPO

    Patient reported recent significant weight loss, TPN initiated

    Small bowel resection

    NGT suctioning, GI bleed, low hemoglobin, multiple transfusions

    Pacemaker, NPO

    Aspiration, Chopped, nectar thickened liquids

    Weaning off TPN with cardiac diet

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    CONCLUSIONS

    Late initiation of PN linked to decreased LOS, time on dialysis,

    time on ventilator, ad risk for infections

    Early PN support in patients that are admitted to the ICU

    malnourished for less complications

    Consideration of adding glutamine to PN for patients in the ICU,especially surgical patients

    Decrease infections

    More research on LOS and mortality

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    REFERENCES

    Dang CD. Acute Mesenteric Ischemia. Medscape.http://emedicine.medscape.com/article/189146-overview. Updated February 22, 2013.Accessed March 22, 2013.

    Tessier DJ. Mesenteric Artery Thrombosis. Medscape.http://emedicine.medscape.com/article/191560-overview. Updated January 6, 2012.Accessed March 22, 2013.

    American Heart Association. What is Atrial Fibrillation (AFib or AF)?. American HeartAssociation. http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-

    is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsp. Updated October 18, 2012.Accessed March 22, 2012.

    American Heart Association. Coronary Artery Disease- Coronary Heart Disease. AmericanHeart Association.http://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsp. Updated February 27, 2013.Accessed March 22, 2013.

    American Heart Association. Prevention and treatment of High Blood Pressure. American

    Heart Association.http://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsp.Updated June 6, 2012. Accessed March 22, 2012.

    http://emedicine.medscape.com/article/189146-overviewhttp://emedicine.medscape.com/article/191560-overviewhttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/HighBloodPressure/PreventionTreatmentofHighBloodPressure/Prevention-Treatment-of-High-Blood-Pressure_UCM_002054_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Coronary-Artery-Disease---The-ABCs-of-CAD_UCM_436416_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/What-is-Atrial-Fibrillation-AFib-or-AF_UCM_423748_Article.jsphttp://emedicine.medscape.com/article/191560-overviewhttp://emedicine.medscape.com/article/191560-overviewhttp://emedicine.medscape.com/article/191560-overviewhttp://emedicine.medscape.com/article/189146-overviewhttp://emedicine.medscape.com/article/189146-overviewhttp://emedicine.medscape.com/article/189146-overview
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    REFERENCES

    McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the Provision and Assessmentof Nutrition Therapy in Adult Critically Ill Patient. Journal of Parenteral and Enteral Nutrition.2009; 33 (3): 285-290. Doi: 10.1177/0148607109335234.

    Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically illadults. New England Journal of Medicine. 2011; 365 (6): 506-517. Doi:10.1056/NEJMoa1102662.

    Estivariz CF, Griffith DP, Luo M, et al. Efficacy of parenteral nutrition supplemented withglutamine dipeptide to decrease hospital infections in critically ill surgical patients. Journal ofParenteral and Enteral Nutrition. 2008; 32 (4): 389-402. doi: 10.1177/0148607108317880.

    Academy of Nutrition and Dietetics. Recommendations Summary CIU: SupplementalGlutamine. Evidence Analysis Library.http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201. AccessedMarch 22, 2013.

    International Dietetics & Nutrition Terminology (IDNT) Reference Manual Third Edition.Chicago, IL: American Dietetic Association; 2011.

    ARAMARK. Patient Food Services Policies & Procedures Volume IV. Updated March 10,

    2010. ARAMARK. Malnutrition Assessment & Diagnosis (DRG coding form).

    Pronsky ZM, Crowe JP. Food Medication Interactions 16thEdition. Birchrunville, PA: Food-Medication Interactions; 2010.

    http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201http://andevidencelibrary.com/template.cfm?template=guide_summary&key=3201