vol. pp. new productsdownloads.hindawi.com/journals/jamc/1997/376192.pdfdiscovery. the aim is to...

Journal of Automatic Chemistry, Vol. 19, No. (January-February 1997) pp. 27-29

New products

Titroprocessor Combinatorial chemistry

The 726 Titroprocessor is the latest member of theMetrohm titrator family. It performs kinetically slowreactions, such as diazotizations and nonaqueous titra-tions, as well as fast reactions, such as acid-base titrations.In addition to this it also performs end-point and KarlFischer titrations (moisture content), plus measures pH,U/mV and temperature and it can be used as an

independent dosing unit.

Results and methods for back titrations, determinationsof pK or HNP (half neutralization potential), ampero-metric titrations, and complex dosing regimes can bestored within the instrument or on a memory card(SRAM card). To facilitate rapid use of the instrumentafter installation, each instrument comes with a read-onlymemory card containing a large number of tried andtested methods.

The 726 Titroprocessor is available with one or two setsof measuring inputs, each set comprising two inputs forhigh impedance electrodes, one for the temperaturesensor and one for the polarized electrode. There arealso four connections for dosing instruments which can beused as titrating or auxiliary burettes. Two RS 232interfaces ensure quick communication with the outsideworld.

On the LCD screen, titration curves in real time,measuring point lists, volume/time curves as well assuperimposed curves can be displayed. The print-outaccording to GLP occurs either on the integrated printeror if preferred an external device.

For further information telephone Metrohm UK Ltd on

01280 824 824.

An application note (No. 222/ICA Version 1) is nowavailable from Micromass Ltd on High Throughput LC-MSVerification ofDrug Candidatesfrom 96-Well Plates. With theadvent of combinatorial chemistry, the pharmaceuticalindustry has radically altered its approach to drugdiscovery. The aim is to vastly increase the number ofpotentially useful organic compounds synthesized, withmany more compounds being screened for biologicalactivity, resulting in more drugs being found morequickly. This stands in contrast to the traditional situa-tion of labour-intensive, step-wise synthesis of individualcompounds and their analogues, which would be fol-lowed by meticulous isolation, purification and charac-terization.

Covering several quite different concepts, combinatorialchemistry originally evolved out of the necessity to

generate a diverse range of large numbers of organiccompounds, the structures of which can be guided bycomputer-aided design. The technique has three basicmethods, for which libraries have been created, consistingof either individual compounds in separate vessels or anentire mixture of reaction products. These libraries arethen screened for biological activity, and any indicationof a positive response results in the isolation, identifica-tion and characterization of a compound. Its efficacy isthen studied by drug metabolism and pharmacokineticstudies.

As the approach to the synthesis of drug candidates hashad to change to meet the high numbers of compoundsrequired, so has the approach to compound characteriza-tion. Previously, when limited numbers of organiccompounds were individually synthesized, each was

The 726 Titroprocessor from Metrohm connected to the company’s 717 Sample changer. See text for details.

0142-0453/97 $12.00 (C) 1997 Taylor & Francis Ltd 27

New products

completely characterized using multiple analytical meth-ods. These included melting point determination, com-bustion analyses, infra-red spectrophotometry, ultra-violet spectrophotometry, nuclear magnetic resonancespectroscopy, and mass spectrometry.

The increase in the number of drug candidates has madethe complete analysis process far too time-consuming andperhaps even unnecessary at the time of initial synthesis,as the majority of compounds synthesized do not exhibitsuitable biological activity. A new analytical techniqueis needed, to state categorically--yes or ’no’--andconfidently whether any of the expected synthetic pro-ducts are present at the end of the syntheses.

Atmospheric Pressure Ionization (API) mass spectro-metry is the most suitable analytical technique capableofmeeting these criteria. It can be applied with equal easeto both single and multi-component samples, the latter ofwhich may require on-line liquid chromatography (LC),and it also generates unambiguous molecular weightinformation for the majority of organic compounds. Theapplication note describes OpenLynx-Diversity, whichintegrates a sample handling system for 96-well plates,an LC procedure, and a bench-top API mass detectorwithin a Microsoft Windows-NT environment.

For further information contact Dr Andrew Eaton, MicromassLtd, Floats Road, Wythenshawe, Manchester, M23 9LZ, UK.Tel.: 0161 945 4170; fax: +44 0161 998 8915; E-mail:andrew, eaton@micromass, co. uk.

Titrator

Until now the Titrino titrators were stand-alone instru-ments; the 721 NET Titrino was designed for PC linkage,and does not have separate keypads. Methods, para-meters, as well as evaluations and calculations areentered via the user’s PC. The system fulfills the require-ments of ISO and GLP, which demands that all settingsand results are stored for several years. The 721 NETTitrino has five operating modes: dynamic titration;monotonic Titration; titration to a fixed endpoint;measurement of pH, voltage or temperature; and pHcalibration with up to nine buffers.

For further information telephone Metrohm UK Ltd on01280 824824.

Materials checking

Perkin-Elmer has introduced a system for materialschecking and assay determination: the IdentiCheck FT-NIR systems. The combination of an FT-NIR spectro-meter, unique sampling options and validated softwareprovides a system which can be optimized to meetspecific operating requirements.

The systems are an alternative to traditional dispersiveNIR instruments, covering the first and second overtoneregions. Utilizing the full first overtone region, whichextends beyond 2,500nm, improves results and allows

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new applications and sampling opportunities. Two sys-tems are available. The Spectrum Identi-Check FT-NIRSystem comprises the IdentiCheck FT-NIIR Spectro-meter and Spectrum IdentiCheck Software forWindows-based, PC-controlled operation. The ParagonIdentiCheck FT-NIR is a fully-integrated system com-prising the IdentiCheck FT-NIR Spectrometer andparagon IdentiCheck Software. Both systems includeflexible and versatile sampling accessories. A reflectanceaccessory allows analysis of powders and tablets, forexample, in their containers, eliminating sample prepara-tion. A remote sampling interface offers remote fibre-optic sampling of liquids and solids and can be installedsimultaneously with the standard transmission and re-flectance systems.

For further information, contact Perkin-Elmer Ltd, PostOffce Lane, Beaconsfield, Buckinghamshire HP9 1QA, UK.Tel.: 01494 676161; fax: 01494 679331/3. E-mailhttp //www.perkin-elmer.com.

FT-IR microscopy

Perkin-Elmer’s AutoIMAGE System integrates a newmicroscope design with the company’s IMAGE software.All microscope operations, including adjustments toaperture, focus and illumination, are automated andcontrolled from a panel on the PC screen. The user alsohas access to new modes of operation, such as automaticATR mapping for surface studies.

Features such as Auto View, Auto Status, Auto Marker,Auto Correlation, Auto Illumination and Auto Modesave analysis time; other key features of the AutoIMAGESystem include Auto Focus, which allows refocusingduring unattended data collection operations such as linescanning or mapping, and Auto Aperture, which enablesusers to interactively select the sampling area on thevisible image. Simultaneous Variable Magnification(SVM) provides users with access to any magnificationview of the sample. The infra-red mapping area isdefined simply by drawing a moveable growbox on thevideo image using the mouse. The AutoIMAGE Micro-scope provides superior IR performance, spatial resolu-tion and visible image quality. With all functionscontrolled via an interactive panel on the PC screen,conventional controls are eliminated for simplicity andspeed of operation.

Forfurther information contact Perkin-Elmer Ltd (as before).

’FAST’ interactive training

Thermo Jarrell Ash Corporation have launched theirFAST (Fully Interactive Atomic Spectroscopy Training)software on CD ROM for all their spectroscopy products.FAST software gives instant access to text and video clips(with sound) explaining the routine operation and main-tenance of the instrument and accessories, as well asinstrument theory.

New products

FAST is a new concept in training designed to providethe operator with virtually all of the information nor-mally given during an intensive training course. How-ever, FAST allows training at the operator’s convenience,and can instantly access specific bits of informationpertaining to immediate topics of interest. FAST isnormally resident on the instrument’s computer andoperates in the Windows environment. Therefore, im-mediate visual and spoken help is available for adjust-ments or optimization parameters that would normallyrequire an operator’s manual and/or a phone call.

For more information contact Thermo Jarrell Ash, 27 ForgeParkway, Franklin, MA 02038, USA. Tel.: 508 520-1880;fax: 508 520 1732.

Benchtop fluorine analysis

Oxford Instruments’ Industrial Analysis Group’sQP20 + is the latest generation of the QP20. These usepulsed Nuclear Magnetic Resonance (NMR) to measurea wide range of components, including water, oil, fats,and chemical products, usually in less than 30 seconds. Anew application package determines fluoride in tooth-paste, fluorine in waste solvents and in alumina smeltingscrubbers.

The analyser now features an optional PC operatingsystem, running under MS Windows. The user is offeredroutine operation by simple keyboard or mouse func-tions, a large clear display of individual results or tabulardisplays of a series of results, fully integrated with MSExcelTM for customized data presentation, and a flexiblePulse Sequence Editor. The analyser is also availablewithout a PC for simple, routine checks of productionsamples as a console operation system.

Further information from Oxford Instruments’ Industrial Analy-sis Group, 130A Baker Avenue Ext., Concord, MA 01742, USA;tel.: 800 447 4717 or 508 371 9009; or 19/20 Nuffeld Way,

Abingdon, Oxon 0X14 1TX, UK; tel.: 01235 532, 123,,fax (01235) 535 0416.Alternative solvents

Following similar developments in the USA and Japan,approvals have now been received for pre-marketing anew range of DuPont cleaning and drying agents in theEuropean Union. The products, to be marketed underthe Vertrel brand, are near ’drop-in’ replacements forozone depleting CFC-based solvents formerly widely usedin the electronics and metal cleaning industries and beingphased out under the Montreal Protocol.

The Vertrel(R) product line is designed to offer analternative to users currently seeking long-term replace-ments for halogenated solvents such as CFC-113, 1.1.1trichloroethane; and for HCFCs such as HCFC-225 ca/cb and HCFC-141b, regulated under the MontrealProtocol. They can also be considered as alternativesfor PFCs (perfluorocarbons) in some applications wherethese have been adopted because of the lack of timelyalternatives to CFC- 13.

The new products are designed to be used in existingequipment, subject to certain DuPont recommendedmodifications to minimize emissions. They are suitablefor removal of a large spectrum of contaminants in thefield of printed circuit board assembly, metal cleaning,decontamination, displacement drying prior to metaliza-tion, high precision cleaning, and also as carrier fluids forlubricant deposition or as dielectric fluids.

Currently manufactured in the company’s Ponca Cityplant in Oklahoma, US, the products will be shipped toEurope from a new plant recently started up at theDuPont Mitsui Shimizu fluorochemicals complex inJapan.Further informationfrom Tim Horsten, Fluorochemicals, DuPontInternational, Geneva, Switzerland. Tel.: + 41-22-717 50 81;fax: + 41-22-717 61 69.

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