VIVITÉ®

The Advanced Glycolic Acid/Antioxidant Line

The Role of Physician-Dispensed Topical Aesthetics

Topical aesthetics can be used to help improve the appearance of skin’s condition alone or in conjunction with other procedures

Topical aesthetics can complement and help promote skin treatments– eg, moisturizers can be beneficial with treatments that leave the skin dry

Patients pleased with their results from facial injectables may wish to complement them through a physician-dispensed skin care regimen

Aesthetic improvements may translate into greater interest in more advanced procedures– ie, dermal fillers, facial injectables, and/or lasers and peels

Behl P. Professional Skin Care 2006, Vol I: United States. Little Falls, NJ: Kline & Company, Inc.

VIVITÉ® Skin Care Products Are Appropriate for All Patients

VIVITÉ® is an advanced glycolic and natural antioxidant system that helps improve the appearance of mild to moderate photodamaged skin in as few as 3 weeks1,2

– Advanced skin care system designed with GLX Technology™*

– Helps improve the appearance of mild to moderate photodamaged skin

– For all skin care patients

– For patients who are dissatisfied with their current skin care system

– Appropriate for all skin types (universal anti-aging system)

*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.1. Data on file. Allergan, Inc.; 2. Downie JB. Cosmet Dermatol. 2008;21:168-175.

VIVITÉ® Line of Skin Care Products

VIVITÉ® Core System

– VIVITÉ® Exfoliating Facial Cleanser

– VIVITÉ® Daily Antioxidant Facial Serum

– VIVITÉ® Revitalizing Eye Treatment

– VIVITÉ® Night Renewal Facial Cream

VIVITÉ® Daily Facial Cleanser

VIVITÉ® Daily Facial Moisturizer SPF 30

VIVITÉ® Vibrance Therapy

VIVITÉ® Replenish Hydrating Cleanser

VIVITÉ® Replenish Hydrating Cream

VIVITÉ® GLX I Facial Peel Gel

VIVITÉ® Defining Lip Plumper

VIVITÉ® Daily Firming Lotion

VIVITÉ® Back Bar Products

– VIVITÉ® Exfoliating Facial Cleanser

– VIVITÉ® Replenish Hydrating CreamData on file. Allergan, Inc.

VIVITÉ® Skin Care Products Are Developed With Proprietary GLX Technology™

VIVITÉ® Skin Care Products are developed with proprietary GLX Technology™– This formula matrix is designed to help act as a vehicle for the deep

penetration of glycolic acid bound to natural antioxidants – Helps enhance the skin’s natural production of hyaluronic acid and

epidermal growth factor (EGF); stimulates collagen; and protects epidermal cells

– Helps allow high amounts of glycolic acid to be released over an extended period for maximum efficacy with minimum irritation

– Helps raise product pH closer to that of normal skin to reduce irritation– Helps retain a reservoir of alpha hydroxy acid (AHA) for secondary

exfoliation

Contains botanicals and innovative ingredients: chamomile, aloe, wild mango butter, green tea, pomegranate, licorice root, caffeine, olive leaf extract, algae extract peptides, superoxide dismutase, exfoliating microbeads, and interference pearls

*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.Data on file. Allergan, Inc.

In a 3-Week Clinical Trial, VIVITÉ® Core Systems Helped Improve Photodamaged Skin

22

36

54

65

0

10

20

30

40

50

60

70

80

90

100

Fine Lines and Wrinkles

Moisture* Smoothness Dryness

Imp

rove

men

t F

rom

Bas

elin

e (%

)

*Mean value of suborbital (38%) and cheek areas (34%).

Downie JB. Cosmet Dermatol. 2008;21:168-175.

After 3 Weeks’ Use

N=24

VIVITÉ® Vibrance Is a Natural Hydroquinone-Free Agent for Skin Brightening

A natural hydroquinone-free agent for skin brightening and even skin tone– Anti-aging GLX Technology™ (glycolic acid, ammonium glycolate, and

olive leaf extract)– Skin brightening/antioxidant complex:

Tyrosinase inhibition – methyl dihydroxybenzoate Increase cellular activity – retinol and glycolic Oxidative inhibition – soy isoflavones, glycyrrhiza glabra (licorice)

root extract, morus nigra (mulberry) fruit extract, grape (vitis vinifera) extract, feoniculum vulgare (fennel) seed extract, lycopene, olea europaea (olive) leaf extract, superoxide dismutase, tocopherol, and magnesium ascorbyl phosphate

– Skin redness reducing actives: allantoin glycyrrhetinic, acid bisabolol, and camellia oleifera (Japanese green tea) leaf extract

– Humectants: glycerin and butylene glycol – Emollients: dimethicone and squalane

*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.

Data on file. Allergan, Inc.

VIVITÉ® Vibrance 8-Week Clinical Trial Design

An 8-week, randomized, double-blind, split-face study of VIVITÉ® Vibrance used on one side of the face (also randomized) and a 4% HQ bleaching gel used on the other side of the face– Expert grader evaluations were made at baseline and at 4 and

8 weeks

– Twenty-one women aged 20 to 75 years with moderate pigmentation of the face participated in the trial; 18 (86%) completed the study

No patients dropped out of the clinical trial due to irritation

McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

VIVITÉ® Vibrance Helped Improve the Appearance of Fine Lines/Wrinkles, Skin Roughness, and Hyperpigmentation After 8 Weeks of Treatment

27%

61%70%

27%

66% 63%

0

10

20

30

40

50

60

70

80

90

100

Fine Lines/Wrinkles Roughness Hyperpigmentation

Natural-based Bleaching Cream 4% HQ Gel

Per

cen

t Im

pro

vem

ent

Expert Evaluator

McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

N=21

VIVITÉ® Vibrance Helped Improve Hyperpigmentation After 8 Weeks of Treatment

Processed UV RBX Brown (hyperpigmentation)

Baseline Week 8 Baseline Week 8

Photos are completely untouched. Individual results may vary.

McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

Summary

Topical aesthetics can be used to help improve the appearance of skin’s condition alone or in conjunction with other procedures

VIVITÉ® is an advanced glycolic and natural antioxidant system that helps improve the appearance of mild to moderate photodamaged skin in as few as 3 weeks1,2

– VIVITÉ® Skin Care Products are developed with proprietary GLX Technology™* which is designed to help act as a vehicle for the deep penetration of glycolic acid bound to natural antioxidants

VIVITÉ® Vibrance is a natural hydroquinone-free agent for skin brightening and even skin tone

– VIVITÉ® Vibrance helped improve the appearance of fine lines and wrinkles, skin roughness, and hyperpigmentation after 8 weeks of treatment3

*GLX Technology™ is owned by Pharma Cosmetix Research, LLC.1. Data on file. Allergan, Inc.; 2. Downie JB. Cosmet Dermatol. 2008;21:168-175; 3. McDaniel DH, Wu J. Cosmet Dermatol. 2008;21:596-602.

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©2010 Allergan, Inc. ® and ™ marks owned by Allergan, Inc.

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