vitix viticolor - cs portugal

VITILIGINOUS SKIN

VITIXVITICOLOR

ACM-ADV_VX-009.indd 1ACM-ADV_VX-009.indd 1 10/22/20 3:56 PM10/22/20 3:56 PM

ACM PATENTED

EXTRAMEL

V

VE

GETAB L E E X T RA

CT

IMPROVES THE PHYSIOLOGICAL FREE RADICAL BALANCE

Vegetal complex (Catalase + SOD): Rich in antioxidant activity

VEG

ETABLE EXTRA

CTEXTRAMEL

VAC

M P A T E NT ED

EPIDERMALFACE

HYPOPIGMENTATION& BODY

VITIXREGULATING GEL

CLINICAL STUDIES

VITIX + UVB PHOTOTHERAPY VERSUS VITIX + HELIOTHERAPY VERSUS PLACEBO + UVB PHOTOTHERAPY (2) HELIOTHERAPY ALONE (3)

DR. A.KEMIS, PROF. JP.ORTONNE - HOSPITAL OF L’ARCHET DR. Y.GAUTHIER - CHU DE BORDEAUX

VITIX DOUBLES THE PROBABILITY OF ACHIEVING SATISFACTORY REPIGMENTATION

EXCELLENT CUTANEOUS TOLERANCE

DIRECTIONS FOR USE:Apply Vitix Regulating Gel 1-2 times a day to affected areas and surrounding areas for 4-6 months.After complete penetration, you may apply a regular skincare cream or make-up.Can be used on its own or in combination with phototherapy.

DAILYSKINCARE

(2) Study into the efficacy of VITIX regulating gel in reducing the lesion plaque by planimetric analysis in UV light in 20 patients for 6 months – A. KEMIS, J.P. ORTONNE – 2002(3) Study into the combination of VITIX regulating gel and heliotherapy in 20 patients for 4 months demonstrating the effi cacy in skin repigmentation – Y. GAUTHIER – 2003

(1) In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with Vitiligo and its successful removal by a UVB-Activated pseudocatalase – Karin U.Schallreuter – The society for investigative dermatology – 1999

GEL WITH MICROSPHERES CONTAINING AND PROTECTING THE VEGETAL ACTIVE INGREDIENT

WHEN APPLIED, THE ACTIVE INGREDIENT IS RELEASED THROUGH CONTACT WITH THE SKIN

50 ml tube

EPIDERMIS OF PATIENTS SUFFERING FROM VITILIGO

Reduction of catalase activity

Increase in hydrogen peroxide level (H2O2)

Cytotoxic for melanocytes

‘‘By restoring a physiological hydrogen peroxide level, we can obtain outstanding

repigmentation even on long-standing vitiligo

‘‘ (1)

Professor Karin U. Schallreuter – Vitiligo Clinic - London u The propability of gaining at least 50% reduction of the surface of the lesion plaque is twice as great with Vitix than with the excipient alone (17,7% versus 35,3%)

u Improvement of repigmentation with Vitix for more than 50% of respondents

35%0%

35%

30%

VITIX <Control zone

VITIX > Control zone

VITIX =Control zone

No clinical improvement

Available in 20 ml

Resp

on

se fr

eq

ue

nc

y fo

r e

ac

h c

lass

14-

12-

10-

8-

6-

4-

2-

0-Number of visits

2 3 4 5 6 7Triangular preferences : target lesions

VITIX > PLB VITIX < PLB VITIX = PLB

ACM-ADV_VX-009.indd 2-3ACM-ADV_VX-009.indd 2-3 10/22/20 3:56 PM10/22/20 3:56 PM

Difficulty of contact t

Internal tension

Apprehension

Sleep disorders *

Sensorial troubles

Irritability *

Pain *

Neurovegetative troubles

Attitude t

Doubt-Indecision

Weariness **

Concentration t

D28 PLACEBO group D28 EXTRAMEL group

Differences between EXTRAMEL and PLACEBO group scores at D28 are statistically significant (* ρ < 0,05 ** ρ< 0,01)Differences between EXTRAMEL and PLACEBO group scores at D28 tend to be statistically different (t ρ <0,1)

*t

EPIDERMAL

INCREASES PRIMARY AND SECONDARY

HYPOPIGMENTATION

ANTIOXIDANT DEFENCES

VITIXTABLETS

DAILY CARE

OXIDATIVE STRESS AND ANTIOXIDANTS DEFENCE SYSTEM

SECONDARY FREE RADICALS

SECONDARY ANTIOXIDANTS(Vitamins A, C, E, Se, Cu, Zn, Polyphenols…)

PRIMARY FREE RADICALS

PRIMARY ANTIOXIDANTS(SOD, Catalase, Glutathione Peroxidases…)

Chain

reactions

Situation of stress in oxidation

(exposure to the sun, sport, age, stress…)

CELLDAMAGE

Cell

OXIDATIONFats

ProteinsADN

O2°-

H2O2OH°

ROO-ROO-ROO-

ACTS AT SOURCE ON PRODUCTION OF FREE RADICALS AND REACTIVE OXYGEN SPECIES (ROS)

(1) Dell’Anna ML and al. Mitonchondrial impairement in peripheral blood mononuclear cells during the active phase of vitiligo. J Invest Dermatol. 2001 oct; 117 (4): 908-13(2) Hasse S and al. Tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. J Invest Dermatol. 2004 feb; 1222 (2): 307-13(3) Ratnam AV and al. Ascorbic acid and melanogenesis. Br J Dermatol. 1977 aug; 97 (2): 201-4(4) Montes LF and al. Folic acid and vitamin B12 in vitiligo: a nutritional approach. Cutis. 1992 Jul; 50 (1): 39-42(5) Picardo and al. Antioxydant treatment in vitiligo (abstract). Pigment Cell Res. 1997; 10: 360(6) Bruske K and al. Zinc and its status in some dermatologic diseases. A statistical assessment. Z Hautkr. 1987; 62 suppl 1: 125-31(7) Juhlin L and al. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure. Acta Derm Venereol. 1997 nov; 77 (6): 460-2

CLINICAL STUDIES

EFFECT OF EXOGENOUS INTAKE ANTI-INFLAMMATORY EFFECTOF EXTRAMEL-SOD ON THE INCREASE IN OF EXTRAMEL-SOD AFTER PLASMATIC SOD ACTIVITY IN PIGLETS (8) EXPOSURE TO UV RAYS (9)

EFFECT OF VITIX TABLETS ON SIGNS AND SYMPTOMS OF FATIGUE AND STRESS (10)

DIRECTIONS FOR USE: 1 tablet per day with water during a meal for 3-6 months

(8) Effect of a SOD-containing melon extract on the increase of plasma SOD activity and the prevention of oxidative stress linked to weaning in piglets INRA - J.P LALLES, J.C DAVID, M.A MILESI, D. LACAN, C. YARD - 2006(9) In vivo study on human skin transplanted onto a mouse - ACM-BIONOV - 2006(10) Ex-stress double-blind study, exogenous intake of catalase + SOD (Extramel-SOD) versus placebo in 70 clean, non-depressive subjects showing signs and symptoms of fatigue and stress

Food supplementBox of 30 tablets

Supplementation given to piglets with dietary intake (Extramel-SOD): 0,7 mg/day for 12 jours

Dose of Extramel-SOD: 0,7 mg/day for 2 weeks before exposure to UV rays

Production of TNF-α (marker of inflammation) after exposition to UV rays

70 subjects from 30 to 55 years1 tablet/day for 28 days

Pla

sma

SO

D a

ctiv

ity (

Ul/

ml)

Extramel-SOD microgranules

400 —

300 —

200 —

100 —

0 —Control

+40%

269

379

TNF

(pg

/ml)

Extramel-SODmicrogranules

200 —

150 —

100 —

50 —

0 —Control

-40%165

95

Gastro-resistantmicrogranules,

coating

PRIMARY ANTIOXIDANTS:Catalase + SOD (1,2)

Eliminate primary free radicals by continuous reaction (non-stœchiometric) so secondary free radicals are not given the chance to appear

SECONDARY ANTIOXIDANTS:Vitamin C (3,4), Vitamin E (1), Selenium (5), Copper (6), Zinc (6)

Eliminate secondary free radicals using stœchiometric reaction

COMPLEMENTARY VITAMINS :Vitamin B9 (7), Vitamin B12 (7)

VE

GE TAB L E E XTRA

CT

PATENTED

EXTRAMEL®

SOD


EPIDERMAL

DEPIGMENTEDFACE

HYPOPIGMENTATION

AREAS CAMOUFLAGE& BODY

VITICOLORSKIN CAMOUFLAGE GEL

50 ml tube

COMPLEMENTARY SKINCARE

IMPROVES QUALITY OF LIFE OF PATIENTSLONG-LASTING ATTRACTIVE COLOURING (3 - 5 DAYS)

IMMEDIATE COLOURING

Colouring agents (CI 42090 – CI 19140 – CI 14700): Give immediate colouring to facilitate the application

LONG-LASTING AND DEEP COLOURING

Pigmenting agents (DHA – Erythrulose): Give uniform and natural colouring without demarcation

CLINICAL STUDIES

IN VIVO TEST : COMBINATION OF DHA + ERYTHRULOSE VERSUS DHA ALONE (2)

LONG LASTING COLOURING AND IMPROVEMENT IN THE MOISTURE LEVEL

BEFORE AFTER

u Long-lasting colouring without imperfections: 4 days

u Reduction of - 30 % in skin dryness

DIRECTIONS FOR USE:Apply on depigmented areas by using the brush for a more precise application.

1/ With the flat part of the brush, start to apply from the center of the depigmented area and then draw the product toward the border to avoid any demarcation.

2/ Leave to dry. After 8 hours, if the resulting colour is too light, renew the application.

3/ Then, one to two applications per week are enough to maintain the coloration.

Can be used as a complement to common vitiligo treatments and phototherapy.

(2) In vivo test of DHA + Erythrulose versus DHA alone showing a long-lasting colouring and an improvement in the moisture level on a back area in 8 volunteers during 20 days(1) Noncarcinogenicity of dihydroxyacetone by skin painting. Markin FJ et al. J. Environ. Pathol. Toxicol. Oncol. 1984 Vol 5 (4-5), 349-351

FOR A SAFE COLOURINGu High cutaneous tolerance (1)

u Fragrance-free

End of application period: D10

ERYTHRULOSE + DHA ERYTHRULOSE + DHADHA DHA

4 days after the last application: D14


Laboratoire Dermatologique ACMImpasse Passoir - 92110 Clichy - France - tel: +33 (0) 1 47 37 80 79 - [email protected]

www.labo-acm.com

shok

ola.

com

- 0

5/20

18 -

Inte

rnal

doc

umen

t. S

tric

tly fo

r La

bora

toire

Der

mat

olog

ique

AC

M e

yes

only.

VITIXVITICOLOR

Vitiliginous skin

VITIXRegulating Gel

1-2 times per day20 ml50 ml

VITIXTablets

Once a dayBox of 30 tablets

VITICOLORSkin Camouflage Gel

1-2 times per week 50 ml

DA

ILY S

KIN

CARE

Prev

entio

n an

d re

gula

tion

COM

PLEM

ENTA

RY S

KIN

CARE

Camouflage

ACM-ADV_VX-009.indd 8ACM-ADV_VX-009.indd 8 10/22/20 3:57 PM10/22/20 3:57 PM

vitix viticolor - cs portugal

Documents