Raksa Andalib HiaID:11146010

Pharmacology II

• What is Vitamin ?

Introduction

Chemistry of vitamin E

structure

structure

Sources of vitamin

Sunflower Seeds

• One ounce of dry-roasted sunflower seeds delivers 7.4 mg of vitamin E.

• Almonds (7.3 mg of vitamin E per ounce)

• Hazelnuts (4.3 mg of vitamin E per ounce)

• peanuts (2.2 mg of vitamin E per ounce)

• Pine nuts (One ounce of pine nuts contains 2.6 mg of vitamin E)

Turnip Greens

• A half cup has 2.9 mg of vitamin E

Tomatoes

• A quarter cup of tomato paste has 2.8 mg of vitamin E.

Avocado

• Half an avocado has 2.1 mg of vitamin E and 161 calories.

Pharmacological properties

1.Prevention of oxidative stress

2.Supporting healthy skin

3.Vitamin E inhibits platelet aggregation

4.Vitamin E may be involved in signal transduction in neuronal cells

Therapeutic indications

• Angina pectoris

• Acne

• Alzheimer’s disease

• Cancer

• Cataracts

• complications in late pregnancy

• Diabetes

• Psoriasis

• Parkinson’s disease

• Respiratory infection etc.

Contraindications

• Contraindications have not yet been identified.

Interactions

1. Vitamin E may increase the anticoagulant effect of warfarin.

2. may decrease the benefits of atorvastatin therapy.

3. Plasma levels of vitamin E may be lowered by anticonvulsants.

Nutrient Interactions

1. Vitamin C

2. Glutathione

3. Selenium

4. Vitamin B3

Deficiency syndrome

1.digestive system problems

2.peripheral neuropathy

Side effects

• High doses of vitamin E may prolong bleeding time.

Hypervitaminosis

1. Intestinal cramps

2. Diarrhea

3. Fatigue

4. Double vision

5. Muscle weakness

Sources

1. http://www.whfoods.com/genpage.php?tname=nutrient&dbid=111

2. http://painandbrainhealingcenter.com/vitaminearticle.html#.UnnXhHCBlfB

3. http://news.vanderbilt.edu/2012/07/high-consumption-of-vitamin-e-may-lower-liver-cancer-risk/

4. http://www.antioxidantsdetective.com/vitamin-e-facts.html5. http://www.webmd.com/vitamins-supplements/ingredientmono-

954-VITAMIN%20E.aspx?activeIngredientId=954&activeIngredientName=VITAMIN%20E

Thank you.

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