vitamin d
TRANSCRIPT
![Page 1: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/1.jpg)
Vitamin D
Submitted by:Prabhjot kaur
![Page 2: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/2.jpg)
Introduction
• It is the collective name given to antirachitic substance.
• These are synthesized in body and found in foods activated by UV radiation.
![Page 3: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/3.jpg)
• D1: mixture of antirachitic substances found in food.
• D2: calciferol,present in irradiated food such as yeast ,fungi ,bread.
• D3: cholecalciferol ,synthesized in skin under the influence of UV rays.
![Page 4: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/4.jpg)
![Page 5: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/5.jpg)
Action of calcitriol
• It enhances absorption of calcium and phosphate from intestine.
• It enhances resorption of calcium and phosphate from bone
• It enhances proximal tubular reabsorption of both calcium and phosphate in kidney
![Page 6: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/6.jpg)
Vitamin D deficiency
• In this ,plasma calcium and phosphate tend to fall due to inadequate intestinal absorption.
• Rickets in children
• Osteomalacia in adults may occur.
![Page 7: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/7.jpg)
Hypervitaminosis D
• It may occur due to chronic ingestion of large doses or due to increased sensitivity of tissues to vitamin D.
• Hypercalcaemia,weakness,fatigue,vomiting,diarrhoea,renal stones,hypertension.
• Even coma may occur.
![Page 8: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/8.jpg)
Treatment
• Its dose should contain the vitamin,low calcium diet,plenty of fluid,and corticosteroid.
![Page 9: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/9.jpg)
Uses
• In prophylaxis : in this prophylactic treatment may be given in obstructive jaundice and other conditions.
• Metabolic rickets; these are group of condition in which the tissues does not give response to vit.D.
![Page 10: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/10.jpg)
Vitamin D resistant rickets
• X linked heredity diseases in which vitamin d metabolism is normal and calcium and phosphate metabolism is deranged.
• Phosphate with high dose of calcitrol.
![Page 11: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/11.jpg)
Vitamin d dependent rickets
• It is a genetic disorder occur due deficiency of renal hydroxylating mechanism.
• Normal doses of calciferol can v given
![Page 12: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/12.jpg)
Renal rickets
![Page 13: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/13.jpg)
• Renal rickets: conversion of 25-OHD3 into calcitriol does not occur due to the chronic renal diseases.
• In postmenopausal osteoporosis:it is an age related problem.in this there is decrease in calcium absorption from gut.
Vitamin D3 and calcium is used
![Page 14: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/14.jpg)
Fanconi syndrome
• In this case vitamin d raise the lowered phosphate level that occur in this condition
![Page 15: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/15.jpg)
Interactions
• Cholestyramine and chronic use of liquid paraffin can reduces vitamin d absorption.
• Phenytoin and phenobarbitone reduces the responsiveness of target tissues to calcitriols.
• Prolong uses of both may cause rickets and osteomalacia.
![Page 16: Vitamin d](https://reader035.vdocuments.site/reader035/viewer/2022070317/5565d472d8b42a8a7b8b52b7/html5/thumbnails/16.jpg)