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VISIT US http://faces.med.nyu.edu/faces-e newsletter FALL 2018 FACES E-NEWSLETTER 1) DR. DEVINSKY FEATURED IN TIME MAGAZINE AS PART OF THE HEALTH CARE 50 2) THE SUDC REGISTRY AND RESEARCH COLLABORATIVE: PROVIDING ANSWERS AND HOPE TO THE LUSIS FAMILY AND BEYOND 3) A NEW EXPERIMENTAL MODEL FOR INFANTILE SPASMS 4) REMEMBERING KEENAN CAMILLERI 5) INTO THE LIGHT EPILEPSY WALK 6) STUDENT SPOTLIGHT – JAKE SCHLOEMANN 7) FUN AT CAMP WITH DIEGO ALCAZAR 8) GORCZYNSKI FAMILY RAISES OVER $55,000 FOR FACES 9) FROM PATIENT TO NURSE BY KATIE HAUCK 10) ALEXANDRA NICKLAS – A JOURNEY OF ACCEPTANCE 11) PUTTING FOR PURPLE 2018 12) HAPPY BIRTHDAY CANDICE STARK! 13) SWATCHED FUNDRAISER BENEFITS FACES 14) REBOUNDWEAR 15) NOTEWORTHY NEWS 1) DR. DEVINSKY FEATURED IN TIME MAGAZINE AS PART OF THE HEALTH CARE 50

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Page 1: VISIT US  newsletter

VISIT US http://faces.med.nyu.edu/faces-e newsletter FALL 2018 FACES E-NEWSLETTER 1) DR. DEVINSKY FEATURED IN TIME MAGAZINE AS PART OF THE

HEALTH CARE 50 2) THE SUDC REGISTRY AND RESEARCH COLLABORATIVE: PROVIDING

ANSWERS AND HOPE TO THE LUSIS FAMILY AND BEYOND 3) A NEW EXPERIMENTAL MODEL FOR INFANTILE SPASMS 4) REMEMBERING KEENAN CAMILLERI 5) INTO THE LIGHT EPILEPSY WALK 6) STUDENT SPOTLIGHT – JAKE SCHLOEMANN 7) FUN AT CAMP WITH DIEGO ALCAZAR 8) GORCZYNSKI FAMILY RAISES OVER $55,000 FOR FACES 9) FROM PATIENT TO NURSE BY KATIE HAUCK 10) ALEXANDRA NICKLAS – A JOURNEY OF ACCEPTANCE 11) PUTTING FOR PURPLE 2018 12) HAPPY BIRTHDAY CANDICE STARK! 13) SWATCHED FUNDRAISER BENEFITS FACES 14) REBOUNDWEAR 15) NOTEWORTHY NEWS

1) DR. DEVINSKY FEATURED IN TIME MAGAZINE AS PART OF THE HEALTH CARE 50

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FACES is thrilled to announce that Dr. Orrin Devinsky has been selected by Time magazine for The Health Care 50. The article highlights his groundbreaking research on cannabidiol’s efficacy in treating seizures. To read the full article, click here. All photo rights to Time

2) The SUDC Registry and Research Collaborative: Providing

Answers and Hope to the Lusis Family and Beyond Ariana Mae Lusis was born into the water and into this world on March 6, 2009. From the moment of her birth, she filled our lives with pure joy. We called Ariana “our sunshine girl” because she was so bright and happy! She had the most incredible blue eyes and we saw a wisdom and peace in her that brought us great comfort. For nearly twenty-one glorious months, we knew what it felt like to have the perfect family. But that perfect life quickly ended the afternoon of November 30, 2010. Ariana hadn’t been feeling well and she was napping in my bedroom. I left the room briefly to do some dishes and give her older brother some attention. When I returned to snuggle, I instantly realized that something wasn’t right. She was unresponsive. What ensued can only be described as hell on earth. Our perfect and beautiful little baby girl had died. A couple of weeks after Ariana died, I became obsessed with finding out why. I stumbled upon some research articles by the SUDC Foundation and febrile seizures. Ariana had a few seizures during times of sickness and suspected this was the cause, but a mother’s intuition does not constitute medical science. My first conversation with Laura Crandall brought such comfort. We were in crisis and I had this person who had experienced the same situation holding my hand and guiding me. The parent email support groups offered by the SUDC Foundation helped me survive many sleepless nights during that first year. We had enrolled in one research study, but it could not explain the death of our precious little girl. Then Ariana’s baby brother, Harper, was born and started having febrile seizures. At 6 months, Harper was diagnosed with a rare and devastating form of epilepsy called Dravet Syndrome. Laura suggested we

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enroll in the SUDC Registry and Research Collaborative at NYU under the direction of Dr. Devinsky. They studied my whole family- determined to help us find an answer. Two years later, I wrote this on Facebook:

“It's been an emotional few days in the Lusis house. Four years of questions were answered yesterday. Four years of insanity are starting to make sense. It seems that the initial genetic tests we had done (at the first research study) were wrong. We now know due to the work at the NYU’s SUDC Registry and Research Collaborative, that the genetic mutation causing Harper's epilepsy is also what caused Ariana's death. It was inherited through low-level mosaicism. Lightning did not strike twice. It struck once and it struck hard. The sadness is always present, but it's taken front and center stage with the new developments. I feel sad and I want my baby girl. I feel scared for Harper. This disease is unbelievably difficult to treat. And yet, I also feel hopeful. Knowledge is power. We are doing everything we can to ensure that Harper is here to stay. To grow up and grow old. To raise a family of his own. I have hope that our family story will help change how doctors treat febrile seizures. I have hope that early diagnosis will save lives. I have hope that SUDC will become a thing of the past and that a cure will be discovered for SCN1a related epilepsies.

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Finally, I feel immense gratitude. I am grateful for our parents, our family and our closest friends that never questioned our need for answers. They never once tried to convince us to let it go. I am grateful for Laura Gould Crandall and the SUDC Foundation. You are my hero and an inspiration. I am grateful for Dr. Orrin Devinsky, who got us the answers we've been so desperately seeking. Thank you for your work! Thank you for fighting for our children! So, there you have it. One hot mess of emotions! We acknowledge them all, but try to keep our focus on the good. Shine on friends!”

Laura, the SUDC Foundation, Dr. Devinsky and the SUDCRRC were tremendous advocates- not only for our daughter- but also for our son. Words can never adequately describe what their work means to our family. Kelly Lusis, Mom of Ariana Lusis

3) A NEW EXPERIMENTAL MODEL

FOR INFANTILE SPASMS By Sloka Iyengar, PhD, PMP Title of study: APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures Journal and citation: Neurobiol Dis. 2017; 98: 149–157. Authors: Antonella Pirone, Jon Alexander, Lauren A. Lau, David Hampton, Andrew Zayachkivsky, Amy Yee, Audrey Yee, Michele H. Jacob, Chris G. Dulla Purpose Infantile spasms (IS) are characterized by characteristic “flexion

extension” spasms that start in infancy, and may progress to cognitive deficits and epilepsy with age

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Another characteristic of IS includes an abnormal EEG pattern known as “hypsarrhythmia”

There is a lack of understanding regarding molecular mechanisms underlying IS, and while treatments for IS do exist, they are associated with many side-effects

Previous studies have shown the involvement of the β-catenin pathway in IS

In this paper, the scientists developed and characterized a mouse model of IS

By developing this mouse model, the scientists wanted to get a more complete picture of pathology in IS, as well as get novel insights to develop new therapies

Description of the study and summary of findings The scientists developed transgenic mice called “APC cKO” mice; in

these mice, the β-catenin pathway is affected They then used an array of methods to characterize these mice

o Electrophysiological analysis revealed an increase in excitatory activity that is similar to what is seen in IS

o The APC cKO mice also showed behavioral spasms and abnormal EEG discharges that are similar to those occurring in infants with IS

o In adulthood, the APC cKO mice showed spontaneous seizures – this is reminiscent of what may occur when infants with IS grow up

What do the results mean? The scientists developed a mouse model of IS that replicated

characteristics of human IS Future work with these transgenic mice will give clues about molecular

mechanisms underlying IS Additionally, this mouse model can also be used to test future therapies

for IS Sloka Iyengar, PhD, PMP Sloka’s graduate work focused on mechanisms of epilepsies. For her postdoctoral work, she investigated the effects of newborn neurons on seizure generation and propagation. She then worked as a clinical research coordinator and was involved in clinical trials in adults and children with refractory

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epilepsies. Currently, Sloka works as an Associate Medical Director at Phase Five Communications. She has lobbied for neuroscience funding on Capitol Hill, and teaches evolution and neuroscience to educators at the American Museum of Natural History. She is also a professional dancer, performing in the New York City area. You can find more about her and contact her at www.slokaiyengar.com.

4) REMEMBERING KEENAN CAMILLERI

FACES expresses our heartfelt sympathy for the Camilleri family. Sadly, Keenan passed away on Monday, October 15, 2018 – just a few months shy of his third birthday. Shawna and Mike – Keenan’s parents – have given us permission to honor his memory, despite their heartbreaking loss. Keenan had the disposition of an angel, and was loved by all who’s lives he touched. In addition to helping organize an extraordinary fundraiser in South Florida for FACES on September 15th, Shawna ran the New York City Marathon on November 4th in memory of Keenan, raising over $25,000. The Garden Gala

On Saturday September 15th, many of South Florida’s business and community leaders paused in their busy lives to gather at the home of Katina and Jorge Garcia, longtime residents of

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Boca Raton for a great cause; an invitation-only Garden Gala to raise funds and awareness for FACES (Finding A Cure for Epilepsy & Seizures).

Katina and Jorge Garcia became involved with FACES through their desire to help their friends, the Camilleri family. Shawna and Michael Camilleri’s son, Keenan, was born with a debilitating rare genetic disease called Microcephaly Capillary Malformation Syndrome. As an infant, Keenan, spent 196 days in the PICU; 27 of those days in Miami before being air ambulanced to NYU Langone Health in New York City. Keenan underwent 2 brain surgeries just after his 1st birthday, a VNS implantation device, then a G-tube. He was on numerous medications around the clock. Most children with this disease are not expected to live past the age of 2.

The Garden Gala included music, dancing, and superb food and beverages provided by two of Boca Raton’s finest dining establishments, Matteo’s and New York Prime. Auction items were unique: a specially commissioned painting and a week’s stay at a luxurious cottage in Martha’s Vineyard. A special video message was delivered by Dr. Orrin Devinsky. The event raised $60,000.

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5) INTO THE LIGHT EPILEPSY WALK On a beautiful Sunday morning at Hudson River Park, our friends at the Epilepsy Foundation of Metropolitan New York held their annual Into the Light Walk fundraiser. Our own Dr. Blanca Vazquez represented NYU Langone Health – Brooklyn with a team in support. Great job to all who participated!

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6) STUDENT

SPOTLIGHT – JAKE SCHLOEMANN

Each year, the FACES College Scholarship provides partial financial assistance to students with epilepsy to use towards their higher education. Below is a personal statement of one of the recipients.

Throughout my

high school career, I have taken an active role in student government as well as the athletics program. As a student council representative, I’ve acted as a liaison between students and high school administrators. I have also helped to create a podcast to report on our sports teams. When not in school, I volunteer as a Heroes and Cool Kids leader teaching middle school students what to expect in the coming years and how to make good life decisions. I also served as a camp counselor during the summer for both the Gridiron Football Camp and Hasbrouck Heights Recreation Program. So when I was diagnosed with Juvenile Myoclonic Epilepsy in 2014 after suffering from a seizure during freshman football practice, I put my leadership and communication skills to work. I reached out to the Anita Kaufman Foundation to ask how I could help bring awareness to the condition and have been working with the foundation as a spokesperson ever since. I have allowed my photo and story to be put on flyers and bookmarks, introduced Purple Day into my school, and raised hundreds of dollars for the organization. Coming from a single parent home with a modest income, scholarship money is a necessity for me. My father is no longer a part of my life and for as long as I can remember my mother has been taking care of my family members in need. First, she opened our home to my brothers, her step-

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children, after they were abandoned by my father. Soon after my brothers graduated high school and moved out, my grandmother was diagnosed with terminal cancer and moved in. Our most recent house guest was my great-grandmother who at 95 could no longer live alone. My mother never complained and always found a way to make ends meet. Unfortunately, at the end of each week there was nothing extra to put into a college savings account. This scholarship has helped me pursue my dream of attending the University of Miami and become a collegiate football coach.

7) FUN AT SUMMER CAMP WITH DIEGO ALCAZAR

Each year, FACES provides partial financial assistance to children with epilepsy to attend the summer camp of their choice via the Dr. Blanca Vazquez Summer Camp Scholarship. Below is a thank you letter from the mother of one of the recipients:

On behalf of my son and the rest of the Alcazar family, I would like to thank FACES and the Blanca Vasquez Summer Camp scholarship, for allowing my son, Diego one more year of horseback riding at the Pony Power summer program. Thanks to you, my son could attend this wonderful program - getting out of the house and his wheelchair to enjoy movement in the outdoors of the farm, even during the hottest days of summer. We will always be grateful to this organization for its kindness and compassion. From the bottom of my heart, Thank you so much. Ligia Arias

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8) GORCZYNSKI FAMILY RAISES OVER $55,000 FOR FACES On September 22, Cindy and Brian Gorczynski hosted a private fundraiser at their residence in New Jersey to benefit FACES. The event was held in honor of their daughter Mia (15) who is currently being treated by Dr. Devinsky. The night was full of friends, family, and amazing music, with live performances by The Nerds and John Rzeznik of Goo Goo Dolls! The night raised over $55,000 to fund FACES research initiatives.

As noted on their fundraising page,

“For Mia, and the 3 million other people in the US and 65 million people around the world affected by epilepsy, it is disheartening to know there is no cure for this neurological condition. Fortunately, however, in many cases, seizures can be controlled with treatment. Thanks to research efforts of organizations like FACES, new treatment therapies and medications have been developed to better manage this condition and decrease the frequency of seizures.”

9) FROM PATIENT TO NURSE

BY: KATIE HAUCK In the middle of my fourth brain

surgery, the anesthesiologist woke me up. Lying on my left side looking down at the floor, I could feel something tickling my head as my doctor spoke to me with commands to move my hand and fingers. For the next 45 minutes, the doctor would ask me to squeeze his hand and whether or not I could feel him touching the tips of my fingers. After a six-hour surgery, I woke up to the nurses doing their best to keep me comfortable. While I greatly appreciated the work of the doctors and surgeons, it would be the nurses who remained by my side every day for the next two months.

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So much of my childhood involved doctors, tests, and trips to the nurse’s office to take my medications. From first grade to sixth grade I had seizures almost every day until we found a dosage that reduced them. Unfortunately, the side effects of my anti-seizure medication were so severe that I was no longer the cheerful little girl I used to be. Even though I had some of the best doctors in the nation, numerous complications caused a three-surgery plan to become a five-surgery battle. Rather than dreading the surgeries, I counted down the days before each one. I cried every time, not because I was scared, but because I couldn’t wait to do something that would turn my life around. Once the plan was derailed due to a risk of paralysis, I felt like I was having surgery every week. Being hospitalized for two months, I got to know all the nurses who saw my attitude go from excited to depressed, as I dealt with the toll taken on my mind and body. They did everything they could from spending hours watching TV with me, to doing arts and crafts in the ICU. The nurses were the ones who stopped at nothing to keep me comfortable after each procedure. When the usual anti-nausea medications didn’t work, they did their best to research new ways to stop it. Margaret, the night nurse, was always telling me about her kids and introducing me to games I could play on my iPad. My favorite nurse, Lindsey, always brought me ice cream and showed me how to make bracelets which I ended up making for every nurse. She even pinned a cloth to my gown that smelled like peppermint

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to help stop my nausea. Before I left, I told the nurses I wanted to be like them when I was older. It’s been five years and there is still nothing I would rather do. Although the surgeries reduced my seizures, I still wake up every morning knowing I could have one. As a result, people are surprised that I always have a smile on my face. I love school and my determination helps me overcome the side effects of my medications, even though I have to work ten times harder than my peers and am not permitted to stay up past 11 pm. Despite these challenges, I still manage to do well in school, play volleyball, and do what makes me happy. Epilepsy is not what defines me, but it has helped me figure out who I want to be. I haven't let 14 years of balancing medications and brain surgeries discourage me; in fact, this has driven me to work even harder so I can pursue a career that will let me help others. Some kids idolize famous singers in hopes to become one; some look up to professional athletes. My heroes are nurses, and Margaret, Lindsey, and many others inspired me to stop at nothing to become one. Someday I hope to be there for my patients the way my nurses were there for me.

10) ALEXANDRA NICKLAS – A JOURNEY OF ACCEPTANCE

During our freshFACES event, Alexandra Nicklas was gracious enough to share her story as a patient speaker, below is the speech she gave. See the FACES holiday issue for a full recap of freshFACES!

I am grateful to be here with you tonight, connected through this amazing organization,

FACES. It took me a long time to get here. As a young girl, as a college student and even a

few years ago, I wouldn’t even step foot in this room. Me and my epilepsy - we did not get

along. Today, I live side by side with my epilepsy. It’s been a process.

Let me tell you my story. My journey of acceptance.

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As a child, I was told I was prone to seizures,

but I never thought I would experience them as

part of my day to day life. Everything changed

the first day of orientation during my freshman

year at Wheaton College.

I spent the day like everyone else - moving into

my dorm room, unpacking, saying goodbye to

my mom and saying hello to the next chapter of

my college life.

And then it happened. I was out with some

new friends, eating pizza, when a piece got

stuck in my throat. Seconds later, my right arm

lost sensation. I started to lose consciousness.

I screamed for help. I thought I was dying. I

was told my seizure lasted for a few minutes; I

fell out of my chair and my body shook

uncontrollably on the floor. EMS came

immediately and rushed me to the hospital.

From that moment on, my life shifted - revolving around regular visits to the doctor,

hospitals, MRI’s, EEGs and physicians, testing-out different seizure medications to help me.

In my college years, if anyone mentioned the word “epilepsy” or the word “seizure” I

couldn’t tolerate it. And the suggestion to join a community like FACES was absolutely out

of the question! I worried about my future. Would I graduate college? Would I get a job?

Would I have friends?

Around this point in my journey, I met Dr. Devinsky. I have vivid memories of my first

appointment. I don’t remember much of what he said when we first met, but I definitely

remember - I was crying hysterically.

Dr. Devinsky has played an important role in my journey.

Over time, he found a medication to adequately control my seizures. I am grateful beyond

words. I have been seizure free for six years. I am proud to say that I graduated from

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Marymount College in 2014 and over the past year, I created Different & Able, an

organization that supports individuals with disabilities.

This was a critical step forward in my journey, and it presented me with the next most

important transition in my life with epilepsy.

I needed to decide how I wanted to live. To live with fear and or to live with courage.

The fear of never following my dreams. The fear of my life crushed by my condition.

Or the courage to persevere. The courage to push forward.

I chose to live with courage.

I refer to this choice as “my acceptance.”

For me, it’s about finding a way to cope and live with the condition - for what it is - while

living my life as fully as possible.

Acceptance and life experience led to four big shifts in my outlook, and my life:

1. BEFORE, I thought: People would not accept me because of my epilepsy;

and doubt my abilities

NOW, I can see that people recognize how capable I am - based on my performance.

2. BEFORE: I could not tolerate epilepsy

NOW, I am comfortable with my epilepsy, and I can talk about it openly.

3. BEFORE, I thought: I could never drive or socialize freely.

NOW, I have my license and drive myself to and from social events with friends.

4. BEFORE, I thought: I was at the mercy of my disorder, loaded with anxiety and

fear.

NOW, with a combination of the right medication, self-education and awareness, my

lifestyle choices contribute to my overall health and functioning.

I’ve come a long way.

As a girl, I didn’t understand the word.

As a young adult, I couldn't handle hearing the word.

Now, as a woman, I stand here talking about it and I can tell you:

epilepsy is a part of me.

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11) PUTTING FOR PURPLE 2018

On Sunday, October 14th, the Harmon family held its 5th Annual Putting for Purple fundraiser for FACES. Over 100 people attended the event which included miniature golf and an inflatable obstacle course. 100 percent of the proceeds were donated to FACES. The event has raised more than $60,000 the past 5 years, including over $12,000 this year. Emily Harmon, age 11, suffers from absence seizures which are now controlled by medication and she is proud to help others by fundraising for FACES.

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12) HAPPY BIRTHDAY CANDICE STARK! Steven Stark threw a party for his wife Candice for her special birthday on May 31st. In lieu of bringing gifts, Candice wished for everyone to make a donation to FACES to show appreciation for everything NY Langone, FACES and Dr. Devinsky do for the Stark’s daughter, Skylar. Controlling Skylar's many seizures has given her a better quality of life and made an extraordinary difference in all their lives. The Stark's raised over $40,000.

13) SWATCHED FUNDRAISER BENEFITS FACES

On Tuesday October 9th, FACES was selected by Chad Stark to be one of the charities of choice at the Swatched Design Game Party Fundraiser, hosted

by the Interior Design Society and held at the Stark Carpet Showroom in Syosset, New York. In this photo, Chad presents FACES executive director, Pamela Mohr with a $1,500 donation.

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14) REBOUNDWEAR

Reboundwear is a clothing company that was inspired by the amazing courage that people find within themselves when they are faced with a struggle. Typically, those with a physical illness or injury are faced with many challenges associated with their condition. And for many dressing, something we all think of as an easy daily task, is actually difficult and often painful.

Bimla Picot watched her own friends and family with this very situation and found it so frustrating that her loved ones started and ended each day with stress and indignity. With a background in high fashion and design, she decided to create a line of clothing that was comfortable and fashionable and, at the same time, functional for a myriad of people with a myriad of health situations. Her mission is to enable everyone to maintain their dignity and style and to

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bring humanity back to healthcare. Bimla conducted 2 years of research and development to help her to create the optimal designs. The studies included talking to patients, caregivers, physical and occupational therapists, doctors and nurses. What we learned is that adults and children, with all kinds of illnesses and aliments, were more interested in talking about their hopes, dreams, and passions, than about their struggles. And we learned that many times something as simple as clothing could be a deterrent in how people live their lives. Starting everyday in clothes that were hard to get dressed in, was a reminder of ones limitations and not of their prospects. We also learned that going to the doctor, getting treatments and going to exercise was a big part of life. The conclusion? If getting dressed at the start of your day was easier and if the clothes in which you were dressing were comfortable, soft and fashionable, then ultimately, one would have a more positive outlook for the rest of their day and they could spend more time thinking about and doing the things they loved. Active lifestyles are such a focus of our culture today and we know that so many people want to be able to get out there in what ever way they can, even if it as simple as a walk to the coffee shop. Reboundwear now makes that easier. Reboundwear applauds the FACES organization in all they do in finding a cure for epilepsy and seizures and for creating a supportive community that encourages patients to strive to be their best selves. Reboundwear can be purchased at: https://www.reboundwear.com/ or on Amazon.

15) NOTEWORTHY NEWS 1) A Sleep Doctor Tells Us How to Sleep Through the Summer

Without AC

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2) Hispanic Creates Scholarship Program for Young People with Epilepsy Who Enjoy Summer Camp

3) Cannabidiol Significantly Reduces Seizures In Patients with Severe Form of Epilepsy

4) There's Even More Evidence That a Drug Derived From Marijuana Offers a Significant Health Benefit

5) Cannabis Oil Could Treat Epilepsy: Landmark Study Reveals it Can Reduce the Severity of Fits By More Than 40 Percent

6) Low Dose of CBD Liquid Eases Epilepsy Seizures: Study 7) Study Finds CBD Drug Epidiolex Reduces Seizures By 42% 8) How to Stop Snoring—and When to See a Doctor About

Dangerous Nighttime Breathing 9) Cannabidiol Significantly Reduces Seizures in Patients with

Severe Form of Epilepsy 10) Cannabidiol Significantly Reduces Seizures in Patients with

Lennox-Gastaut Syndrome 11) Marijuana Constituent Significantly Reduces Severe Epileptic

Seizures 12) CBD Significantly Reduces Seizures In Patients with Severe

Form of Epilepsy 13) Growing Promise: The Future of Medical Marijuana 14) Zeto Announces First Dry Electrode, Wireless EEG Headset

Approved By FDA for Clinical Use 15) Novel Cannabidiol Medication Reduces Seizures From Severe

Epilepsy 16) Cannabidiol Significantly Reduces Seizures in Patients with

Severe Form of Epilepsy 17) NeuroPace Launches Next Generation RNS System, the

World’s Only Brain-Computer Interface for the Treatment of Refractory Epilepsy

18) What Is CBD Oil? 19) There’s a Sea Change Coming for the $1 Billion Marijuana-

Based Industry You’ve Never Heard of 20) Patients with Epilepsy at Increased Risk for Unnatural Death 21) GW Pharmaceuticals plc and Its U.S. Subsidiary Greenwich

Biosciences Announce FDA Approval of EPIDIOLEX® (Cannabidiol) Oral Solution – the First Plant-derived Cannabinoid Prescription Medicine

22) FDA OKs First Drug Containing Marijuana-Derived Ingredient

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23) FDA Approves First Prescription Medication Made From Marijuana

24) FDA Approves First Marijuana-Derived Drug 25) A Drug Derived From Marijuana Has Become the First to Win

Federal Approval, and Experts Predict an Avalanche Effect 26) First FDA-Approved Drug Made From Marijuana Has N.J. Ties 27) Low Dose of CBD Liquid Eases Epilepsy Seizures: Study 28) The FDA Approved a Pot-Derived Drug for Seizures — Will

the DEA Allow It to Be Sold? 29) Cincinnati Tested the Marijuana Drug That the FDA Has Just

Approved 30) FDA Approves First Marijuana-Based Drug for Seizures 31) FDA Approves First Cannabis-Based Drug 32) How a Cincinnati Doctor Helped In the FDA Approval of

Epidiolex 33) FDA Approves Medical Marijuana 34) A New Cannabis-Based Epilepsy Drug Is Going to Change

Lives 35) Brain Implant Puts the Brakes on Epileptic Seizures in Mice 36) Epilepsy Foundation Puts the Brain Front and Center to Rally

Everyone to End Epilepsy 37) Epilepsy Foundation Awards Three Million Dollar Grant to

International Team of Scientists to Improve Seizure Forecasting 38) 50 Most Influential People In Healthcare Cited In Inaugural

Time Magazine List 39) Seven Things Your Body Is Trying to Tell You When You Can’t

Fall Asleep 40) First FDA-approved cannabis-based drug now available in the

US 41) GW Pharmaceuticals: First FDA-Approved Cannabis-Based

Drug Now Available In the U.S. 42) The First FDA-Approved Cannabis-Derived Drug Is Available

for Prescription In the U.S. 43) First U.S. Drug Containing Marijuana-Derived Ingredient Goes

On Sale 44) First FDA-Approved Marijuana Drug Available Across All

U.S. States