virus entry - c-linkage.co.jpryosuke suzuki, hideki aizaki, fumio sugawara, naoko otani, takaji...

23rd International Symposium on Hepatitis C Virus and Related Viruses / 101

POSTERS

P-1 SilencingofCD81andClaudin-1expressionbysmallinterferingRNAsinhibitsHCVentryAnirban MANDAL, Krishna Kumar GANTA, Binay CHAUBEY

P-2 IdentificationandanalysisofanovelimportantenveloperegionrequiredforHCVinfectionNoriyuki WATANABE, Nanako AIHARA, Tomoko DATE, Hussein H ALY, Hideki AIZAKI, Takaji WAKITA

P-3 MonoclonalantibodiesagainsttheextracellulardomainsofoccludinblockhepatitisCvirusinfectioninhumanliverchimericmiceMasayoshi FUKASAWA, Yoshimi SHIMIZU, Yoshitaka SHIRASAGO, Tetsuro SUZUKI, Takaji WAKITA, Kentaro HANADA, Kiyohito YAGI, Masuo KONDOH

P-4 CD81-independentHCVentryutilizingvery-low-densitylipoproteinreceptorSaneyuki UJINO, Hironori NISHITSUJI, Kunitada SHIMOTOHNO

P-5 VanitaracinAisanovelentryinhibitorofhepatitisBandDvirusesthroughtargetingNTCPManabu KANEKO, Koichi WATASHI, Shinji KAMISUKI, Masashi IWAMOTO, Senko TSUKUDA, Hirofumi OHASHI, Fumihiro KAWAI, Masashi MIZOKAMI, San-Yong PARK, Yasuhito TANAKA, Ryosuke SUZUKI, Hideki AIZAKI, Fumio SUGAWARA, Naoko OTANI, Takaji WAKITA

P-6 RetinoidinhibitorsabolishthehostpermissivenesstohepatitisBvirusinfectionbymodulatingtheexpressionofNTCPSenko TSUKUDA, Koichi WATASHI, Masashi IWAMOTO, Ryosuke SUZUKI, Hideki AIZAKI, Soichi KOJIMA, Masaya SUGIYAMA, Yasuhito TANAKA, Masashi MIZOKAMI, Takaji WAKITA

Virus entry


POSTERS

P-7 ISG12inhibitsHCVreplicationthroughactivationoftheJak/STATsignalingpathwayYanzhao CHEN, Chen LIMIN

P-8 HIV-1andHCVhavecomparablegeneticandphenotypicproteasequasispeciesdiversityMiguel Angel MARTINEZ, Ana JORDAN-PAIZ, Maria NEVOT, Sandra FRANCO

P-9 Non-StopmediatedRNAdecaymechanismregulatesHepatitisBvirusreplicationHussein H. ALY, Koichi WATASHI, Kazuaki CHAYAMA, Takaji WAKITA

P-10 ExploringinteractionsbetweenGBF1andHCVproteinsYves ROUILLE, Lucie GOUESLAIN, Najet LEBSIR, Rayan FARHAT, Francois PENIN, Jean DUBUISSON, Catherine L JACKSON

P-11 AroleforphosphorylationinLCSIinregulatingcellularinteractionsofHCVNS5ANiluka GOONAWARDANE, Mark HARRIS

P-12 ThecomplexrelationshipbetweenNS5Ahyperphosphorylationandgenomereplication:definingaroleforresidue146Niluka GOONAWARDANE, Mark HARRIS

P-13 Inositolpolyphosphate-5-phosphataseFfacilitateshepatitisCvirusreplicationviaupregulatingautophagyYu-Hsuan WU, Ching-Kai TSENG, Kung-Chia YOUNG, Jing-Ching LEE

P-14 RegulationofHepatitisCVirusbytRNA-derivedSmallNon-codingRNAsHee CHO, Wooseong LEE, Geon-Woo KIM, Jae-Su MOON, Jong-Won OH

P-15 TheHCVcellculturesystemidentifiedfungal-derivedneoechinulinBasanovelantagonistofliverXreceptorKoichi WATASHI, Syo NAKAJIMA, Hirofumi OHASHI, Shinji KAMISUKI, Andrew Tae-Jun KWON, Harukazu SUZUKI, Senko TSUKUDA, Ryosuke SUZUKI, Hideki AIZAKI, Takanobu KATO, Fumio SUGAWARA, Takaji WAKITA

P-16 VariantfitnesscompensationinHCVbyrescueofdistinctNS3proteasefunctionsandinnateimmuneescapemechanismsGeorg DULTZ, Tetsuro SHIMAKAMI, Murai KAZUHISA, Iris ANTES, Stefan ZEUZEM, Robert TAMPÉ, Stanley M LEMON, Christoph WELSCH

P-17 YellowFevervirusgenome-derivedsmallRNAreducesTcellactivationandenhancesviralreplicationbytargetingthePTPREphosphataseJack T STAPLETON, James H MCLINDEN, Nirjal BHATTARAI, Qing CHANG, Thomas M KAUFMAN, Suzanne L CASSEL, Fayyaz S SUTTERWALA, Hillel HAIM, Donna KLINZMAN, Jinhua XIANG

P-18 UsingproteomicstoidentifynovelhostproteinsregulatingHepatitisCVirusinfectionHolly RAMAGE, Renuka KUMAR, Nevan KROGAN, Melanie OTT

Virus replication

108 / HCV 2016

POSTERS

POSTERS

P-19 DifferentialhepatitisCvirusRNAtargetsiteselectionandhostfactoractivitiesofnaturally-occurringmiR-1223’variantsDaisuke YAMANE, Sara R SELITSKY, Tetsuro SHIMAKAMI, You LI, Masao HONDA, Michinori KOHARA, Praveen SETHUPATHY, Stanley M LEMON

P-20 AnnexinsparticipateintheHCVRNAreplicationTakayuki ABE, Ikuo SHOJI, Yoshiharu MATSUURA

P-21 CooperativestimulationofHepatitisCVirusRNAtranslationbymicroRNA-122/Argonaute2complexesMichael NIEPMANN, Anika NIEDER-RÖHRMANN, Nadia DÜNNES, Gesche K GERRESHEIM, Lyudmila A SHALAMOVA

P-22 InVitroSelectionofSimeprevir-resistanceMutantsforHepatitisCViruswithNS3-Q80KPolymorphisminGenotype1aTetsuro SHIMAKAMI, Kazuhisa MURAI, Christoph WELSCH, Takayoshi SHIRASAKI, Masao HONDA, Shuichi KANEKO

P-23 IdentificationessentialhostfactorsforhepatitisCvirusinfectionbyahigh-throughputCRISPR-Cas9screeningstrategyWei YANG, Yuqiang NIU, Min CHENG, Youhui SI, Xiaojing CHI, Xiuying LIU

P-24 INTRACELLULARPROTECTIONOFHSPB8PROTEININHCVINFECTIONSPaula RAHAL, Ana Claudia S BRAGA, Mariana N BATISTA, Mônica M AKINAGA, Bruno M CARNEIRO

P-25 CellCulture-AdaptiveMutationsofNS5AAffectReplicationofHepatitisCVirusDifferentiallyDependingontheViralGenotypesSeungtaek KIM, Aeri CHUNG, Bora JIN, Kwang-Hyub HAN, Sang Hoon AHN

P-26 PrevalenceofHCVandFirstreportofcompletegenomesequenceofHCVamongthegeneralpopulationinCambodiaChikako YAMAMOTO, Shintaro NAGASHIMA, Somana SVAY, Sirany HOK, Son Huy DO, Channarena CHUON, Hiroko FUJII, Mayumi FUJIMOTO, Shiho SAITO, Muzembo Basilua ANDRE, Keiko KATAYAMA, Kazuaki TAKAHASHI, Junko TANAKA

P-27 VitB12decreasesHCVreplicationinrepliconcelllinesJee-Fu HUANG, Chia-Yen DAI, Ming-Lung YU, Wan-Long CHUANG

P-28 HepatitisBviruscapsidformationisregulatedbymicrotubulesandtheirposttranslationalmodificationMasashi IWAMOTO, Masaya SUGIYAMA, Ryosuke SUZUKI, Hideki AIZAKI, Yasuhito TANAKA, Masashi MIZOKAMI, Naoko OHTANI, Takaji WAKITA, Koichi WATASHI

P-29 DNA-PKcsandRad18arerequiredforHCVreplicationYasuo ARIUMI, Satoshi TATEISHI, Takaji WAKITA, Nobuyuki KATO

P-30 ThemechanismsofepigeneticregulationonhypericininhibitingHCVreplicationChao-ming SHIH, Chih-hsien WU, Jiunn-liang KO


POSTERS

P-31 PathogeniccontributionofMacrophagemigrationInhibitoryFactor(MIF)duringHepatitisCvirus(HCV)infectionChing Wooen SZE, Wei Kiang LIM, Victor C YU, Yee-Joo TAN

P-32 AdaptationofpreviouslydevelopedinfectiousclonesofhepatitisCvirusgenotypes1and2toHuh7cellsYiping LI, Fuxiang ZHENG, Liang RONG, Jiemin SHEN, Yetong FENG

P-33 TheroleofautophagyintheformationofdoublemembranevesiclesinHCV-infectedcellsKeisuke TABATA, David PAUL, Ralf BARTENSCHLAGER

P-34 AminoacidsubstitutionsinIFNsensitivity-determiningregionofHCV-NS5AaffectinfectiousvirusproductionandISGinductionRyuichi SUGIYAMA, Nao SUGIYAMA, Asako MURAYAMA, Megumi TASAKA-FUJITA, Norie YAMADA, Sayuri NITTA, Takahiro MASAKI, Koji ISHII, Akihide RYO, Takaji WAKITA, Takanobu KATO

Virus replication


POSTERS

P-35 Rab32isanessentialhostfactorforhepatitisCvirusparticleassemblySoon B HWANG, Tu M. PHAM, Yun-Sook LIM

P-36 NeglectedbutImportantRoleofApolipoproteinEExchangeinHepatitisCVirusInfectionGang LONG, Zaili YANG, Xiaoning WANG, Xiumei CHI, Fanfan ZHAO, Jinxu GUO, Pengjuan MA, Jin ZHONG, Junqi NIU, Xiaoyu PAN

P-37 QuantitativeLipidDropletProteomeAnalysisIdentifiesAnnexinA3asaCofactorforHepatitisCVirusParticleProductionEva HERKER, Kathrin ROESCH, Marcel KWIATKOWSKI, Sarah HOFMANN, Anja SCHOEBEL, Cordula GRUETTNER, Marcus WURLITZER, Hartmut SCHLUETER

P-38 NF- κ B-inducingkinase(NIK)activatesIKK- αinregulationofhepaticlipogenesisandhepatitisCvirusassemblyQisheng LI, Brianna LOWEY, Stephan CHIU, Fang ZHANG, Kristin VALDEZ, T Jake LIANG

P-39 InfluenceofapolipoproteinEonhepatitisCvirusenvelopeproteinsfoldingJulie DRENEAU, Anne BULL, Elodie BEAUMONT, Philippe ROINGEARD, Audrey BOYER, Jean-Christophe MEUNIER

P-40 CriticalRoleoftheBasicResidueClusterswithinDomain-IofHCVCoreinInteractionwithViralGenomeandParticlesassemblyGuoli SHI, Mami MATSUDA, Ryosuke SUZUKI, Takaji WAKITA, Tetsuro SUZUKI

P-41 HostGlycometabolismModulatesHepatitisCVirusReleaseTao YU, Jin ZHONG

P-42 Cell-death-inducingDFFA-likeEffectorBContributestotheAssemblyofHepatitisCVirus(HCV)ParticlesandInteractswithHCVNS5AHua CAI, Wenxia YAO, Leike LI, Xinlei LI, Longbo HU, Runming MAI, Tao PENG

Viral assembly


POSTERS

P-43 TheMetabolicRegulatorHistoneDeacetylase9ContributestoGlucoseHomeostasisAbnormalityInducedbyHepatitisCVirusInfectionChen JIZHENG, Wang QIAN, Chen XINWEN

P-44 CriticalroleofCREBHactivationinducedinHCV-infectedcellsinenhancingprofibrogenicresponsesinnearbyhepaticstellatecellsTakeshi CHIDA, Masahiko ITO, Kenji NAKASHIMA, Tetsuro SUZUKI

P-45 HepatitisCvirus-inducedinflammasomeregulateslipidmetabolismGulam WARIS, Steven MCRAE, Jawed IQBAL, Mehuli SARKAR-DUTTA, Samantha LANE, Abhiram NAGARAJ, Naushad ALI

P-46 PilotanalysisrevealsSPINK1asanimminentdiagnosticmarkerforHepatitisBandC-associatedHepatocellularCarcinomaobservedinIndonesianpatientsSiti Eriaty Nur RUSLAN, Juniastuti, Bagaswoto Poedjo MARTONO, Nihayatus SA’ADAH, Mochamad AMIN, Soetjipto, Maria Inge LUSIDA

P-47 UpregulationofMAPKphosphatase3isinvolvedinHCV-induceddephosphorylationofFoxO1Lin DENG, Ming CHEN, Ikuo SHOJI, Hak HOTTA

P-48 HumanhepaticstellatecellsarepermissiveforhepatitisCvirusinfection/replicationandplayimportantrolesinfibrosisTakuma ZAITSU, Haruyo AOYAGI, Mami MATSUDA, Noriyuki WATANABE, Akira FUJIMOTO, Koichi WATASHI, Ryosuke SUZUKI, Takasuke FUKUHARA, Yoshiharu MATSUURA, Kenjiro WAKE, Tetsuro SUZUKI, Tomokazu MATSUURA, Koji TAMURA, Takaji WAKITA, Hideki AIZAKI

P-49 AnalysisofcellularfactorsinvolvedintheparticleformationandsecretionofhepatitisCvirusKenichi MORIKAWA, Goki SUDA, Jerome GOUITTENOIRE, Darius MORADPOUR, Naoya SAKAMOTO

P-50 HCV-proteinexpressionexacerbatehepaticpathogenesisinducedbyPTENloss,throughenhancedliverinflammationHerve LERAT, Marion MERCEY, Mohamed-Rabah IMACHE, Natael SOREL, Jacqueline POLYTE, Aurore GAUDIN, Matteo MONTANI, Jean-Francois DUFOUR, Jean-Michel PAWLOTSKY

P-51 AnalysisofviralvariantspectraprovidesevidenceforearlyinuterotransmissionofhepatitisCvirusfrommothertochildVirginie CALDERON, Ariane LAROUCHE, Sébastien FAUTEUX-DANIEL, Marc BOUCHER, Normand LAPOINTE, Fatima KAKKAR, Isabelle BOUCOIRAN, Armelle LE CAMPION, Hugo SOUDEYNS

P-52 LipidMetabolisminRelationtoDevelopmentofSteatosisinHepatitisCVirusInfectedHepatocyte-likeCellsWilson TAT, Rineke STEENBERGEN, D. Lorne TYRRELL

P-53 AmeliorationofHCVliverfibrosisbyselectiveinhibitorofWnt/ β -catenin/CBPsignalingMichinori KOHARA, Yuko TOKUNAGA, Yosuke OSAWA, Takahiro OHTSUKI, Kenzaburo YAMAJI, Daisuke YAMANE, Keisuke MUNEKATA, Mitsuko HARA, Soichi KOJIMA, Kiminori KIMURA

Pathogenesis

132 / HCV 2016

POSTERS

POSTERS

P-54 MolecularmechanismofHCV-inducedlysosomaldegradationofHNF-1 αproteinChieko MATSUI, Nanae MINAMI, Lin DENG, Ikuo SHOJI

P-55 FromAcutetoChronicStagesofHepatitisCVirusInfectionsinCultivatedReporterCellsTsai PEIJU, Cheng HSIANG-LIN, Young KUNG-CHIA

P-56 OverexpressedproteinkinaseR(PKR)inhepatocellularcarcinomawithHCVinfectionmodulatesDNAmethylationTakao WATANABE, Yoshio TOKUMOTO, Masashi HIROOKA, Osamu YOSHIDA, Yohei KOIZUMI, Yusuke IMAI, Yoshiko NAKAMURA, Masanori ABE, Yoichi HIASA

P-57 HEPATITISCVIRUSCOREPROTEINOFGENOTYPE3aDOWNREGULATESPTENEXPRESSIONINHEPATOCYTESTHROUGHMICRORNAs-DEPENDENTMECHANISMSSophie CLÉMENT, Cyril SOBOLEWSKI, Stéphanie CONZELMANN, Francesco NEGRO, Michelangelo FOTI

P-58 RegulationofBcl-2familyproteinsincellsinfectedwithFlavivirusesToru OKAMOTO, Tatsuya SUZUKI, Shinji KUSAKABE, Junki HIRANO, Makoto TOKUNAGA, Takasuke FUKUHARA, Yoshiharu MATSUURA

P-59 DeregulationofWnt-beta-cateninsignalingbyhepatitisCvirusinfection-inducedselectivedegradationsofDishevelledfamilyproteinsPo-Yuan KE, Chih-Wei CHANG

P-60 HepatitisCvirustargetsthemicroRNA-inducedsilencingcomplexandattenuateshostcellularmicroRNAfunctionsTakahiro MASAKI, Takanobu KATO, Yoshihiro MEZAKI, Mariko NAKAMURA, Tomokazu MATSUURA, Takaji WAKITA

P-61 FunctionalstudiesofHepatitisCcore+1/ARFPproteinSavvina MOUSTAFA, Ioannis KARAKASILIOTIS, Niki VASSILAKI, Katerina KASSELA, Sevi FRAKOLAKI, Penelope MAVROMARA

P-62 HepatitisvirusesinducespreadoflivercancercellsthroughgenerationofinvadopodiaLiat NINIO, Avraham NISANI, Ateret DAVIDOVICH, Joel ALTER, Hava GIL-HENN, Meital GAL-TANAMY

P-63 Adenylatekinase4modulatesdrugsensitivityandmitochondrialactivityinHeLacellsKoichi FUJISAWA, Taro TAKAMI, Toshihiko MATSUMOTO, Naoki YAMAMOTO, Isao SAKAIDA

P-64 CytotoxicFunctionofBystanderActivatedCD8+TCellsisAssociatedwithLiverInjuryinAcuteHepatitisAEui-Cheol SHIN, Jihye KIM, Dong-Yeop CHANG, Hyun Woong LEE, Hyung Joon KIM


POSTERS

P-65 ThedetectionofironmetabolismrelatedgenewiththeliverbyNASHmodelratTeruhisa HIGUCHI, Akiko HUKUSHIMA, Kazushige NIREI, Hiroshi MATSUMURA, Mitsuhiko MORIYAMA

P-66 ProteaseinhibitorresistanceremainsevenaftermutantstrainsbecomeundetectableusingdeepsequencingMichio IMAMURA, Hiromi KAN, Nobuhiko HIRAGA, Takuro UCHIDA, Hiromi KAN, Hiromi ABE, Hiroshi AIKATA, Hidenori OCHI, C. Nelson HAYES, Kazuaki CHAYAMA

P-67 ModulationofmetabolicpathwaysbymiR-124duringHCVinfectionTyler SHAW, Megan POWDRILL, Dennis ÖZCELIK, Curtis QUAN, Ragunath SINGARAVELU, John P PEZACKI

P-68 HepatitisCviruscoreproteininteractswithBnip3andsuppressesitsdimerizationandbindingwithLC3Takeya TSUTSUMI, Akira KADO, Kazuya OKUSHIN, Kenichiro ENOOKU, Hidetaka FUJINAGA, Kyoji MORIYA, Hiroshi YOTSUYANAGI, Yumi KANEGAE, Izumu SAITO, Yoshiharu MATSUURA, Kazuhiko KOIKE

P-69 Mutationinthepromoterregionofpre-S1isassociatedwithreduceddiseaseactivityofhepatitisBvirusinfectionKazushi SUGIMOTO, Suguru OGURA, Norihiko YAMAMOTO, Motoh IWASA, Yoshiyuki TAKEI

P-70 MappingtheregionresponsiblefordiseaseprogressionintheHBVpreS1/S2genomebydeepsequencingYuichiro SUZUKI, Shinya MAEKAWA, Mitsuaki SATO, Masaru MURAOKA, Shuya MATSUDA, Natsuko NAKAKUKI, Yasuhiro NAKAYAMA, Taisuke INOUE, Minoru SAKAMOTO, Nobuyuki ENOMOTO

Pathogenesis


POSTERS

P-71 ReactivationofhepatitisBvirusduringsuccessfultreatmentofhepatitisCviruswithinterferon-freedirect-actingantiviralMasaaki KORENAGA, Keiko KORENAGA, Tatsuya KANTO, Masashi MIZOKAMI

P-72 Analysisofglypican-3asapredictivemarkerforpostoperativerecurrenceofHCVrelatedhepatocellularcarcinomaKazuya OFUJI, Keigo SAITO, Hidetaka MATSUDA, Masahiro OHTANI, Katsushi HIRAMATSU, Tomoyuki NEMOTO, Yasunari NAKAMOTO, Tetsuya NAKATSURA

P-73 PhylogeneticandphylodynamicanalysisofhepatitisCvirusgenotype1ainOkinawa,JapanKunikazu HOSHINO, Masaya SUGIYAMA, Tatsuji MAESHIRO, Tomoko DATE, Hirotaka SHOJI, Yohei MANO, Hiroyoshi DOI, Sachiyo YOSHIO, Tatsuya KANTO, Masashi MIZOKAMI

P-74 ComparisonofpatientcharacteristicsandsurvivalbetweenelderlyandyoungerpatientswithhepatocellularcarcinomarelatedtohepatitisCvirusinfectionTomoyuki NEMOTO, Hidetaka MATSUDA, Masahiro OHTANI, Katsushi HIRAMATSU, Yasunari NAKAMOTO

P-75 TheimpactsofZepatierorHarvonitreatmentonplasmalipidprofilesinchronichepatitisCpatientsChiung-Ying TSENG, Hung-Yu SUN, Wei-Jen TSAI, Pin-Nan CHENG, Yen-Cheng CHIU, Ting-Tsung CHANG, Kung-Chia YOUNG

P-76 EfficacyandsideeffectsofsofosbuvirandribavirininpatientswithhepatitisCvirusgenotype2infectionSayuri NOMURA, Naoto KAWABE, Tomoki TAKAMURA, Takamitsu KURASHITA, Yuka OCHI, Masashi OHKI, Kazunori NAKAOKA, Toshiki KAN, Takuji NAKANO, Michihito MURAO, Senju HASHIMOTO, Kentaro YOSHIOKA

P-77 Daclatasvir/AsunaprevirtreatmentincreasesalbuminlevelsToshiki KAN, Naoto KAWABE, Sayuri NOMURA, Tomoki TAKAMURA, Takamitsu KURASHITA, Yuka OCHI, Masashi OHKI, Kazunori NAKAOKA, Takuji NAKANO, Michihito MURAO, Senju HASHIMOTO, Kentaro YOSHIOKA

P-78 Theinfluenceofserumfattyacidprofileandtheeffectofezetimibecombinationonsimeprevirwithpeg-interferon/ribavirintherapyTakao WATANABE, Yoshio TOKUMOTO, Masashi HIROOKA, Osamu YOSHIDA, Yohei KOIZUMI, Yusuke IMAI, Yoshiko NAKAMURA, Masanori ABE, Yoichi HIASA

P-79 Interferonlambda4(IFNL4)CChostgeneticvariantislinkedwithspontaneousHCVclearanceforgenotypes1,2,and3Anders WIDELL, Marianne ALANKO-BLOMÉ, Vilma MOLNEGREN, Per BJÖRKMAN, Kristina NYSTRÖM, Martin LAGGING

P-80 AmulticenterobservationalstudyevaluatingtheantiviralefficacyandsafetywithchronichepatitisCreceivingasunaprevir/daclatasvirtherapyYoshio TOKUMOTO, Takao WATANABE, Koji JOKO, Kojiro MICHITAKA, Yoshiyasu KISAKA, Norio HORIIKE, Seiji NAKANISHI, Yoshinori TANAKA, Yoshiko NAKAMURA, Yusuke IMAI, Yohei KOIZUMI, Osamu YOSHIDA, Masashi HIROOKA, Masanori ABE, Yoichi HIASA

Clinical research

150 / HCV 2016

POSTERS

POSTERS

P-81 Theeffectofdirect-actingantiviraltherapyforpatientswithhepatitisCvirusandhepatitisBviruscoinfectionKazuhiko HAYASHI, Masatoshi ISHIGAMI, Yoji ISHIZU, Teiji KUZUYA, Takashi HONDA, Isao NAKANO, Yoshiki HIROOKA, Hidemi GOTO

P-82 AnalysisofHepatitisCVirusNS3andNS5AResistanceMutationsafterDaclatasvirplusAsunaprevirTreatmentFailuresinKoreaSeungtaek KIM, Hye-Jung PARK, Hye Won LEE, Kwang-Hyub HAN, Sang Hoon AHN

P-83 CombinationTherapywithPeginterferonandEntecavirforPersistentViralSuppressioninPatientswithChronicHepatitisBSatoru HAGIWARA, Naoshi NISHIDA, Masatoshi KUDO

P-84 TheExperienceofDaclatasvirandAsunaprevirTreatmentinKoreanPatientswithGenotype1bHepatitisCVirusInfectionSeungtaek KIM, Hye Won LEE, Beom Kyung KIM, Seung Up KIM, Jun Yong PARK, Do Young KIM, Kwang-Hyub HAN, Sang Hoon AHN

P-85 ClinicopathologicalCharacteristicsofSteatohepatiticHepatocellularCarcinomaMakiko TANIAI, Etsuko HASHIMOTO, Kazuhisa KODAMA, Tomomi KOGISO, Katsutoshi TOKUSHIGE

P-86 PretreatmentglucosestatusdeterminesHCCdevelopmentinHCVpatientswithmildliverdiseaseaftercurativeanti-viraltherapyHuang CHUNG-FENG, Dai CHIA-YEN, Huang JEE-FU, Chuang WAN-LONG, Yu MING-LUNG

P-87 Adetailedhepatitisviralmarkerstudyin3843hepatocellularcarcinomapatientsFromTaiwanLiverCancerNetworkShiu-Feng HUANG, Il-Chi CHANG, Pei-Jer CHEN, Chi-Lin CHEN, Tseng-Chang YEN, Yu-Fan LIAW

P-88 Anti-HDGF(hepatoma-derivedgrowthfactor)treatmentasapossiblenewtherapyforhepatocellularcarcinomaHirayuki ENOMOTO, Hideji NAKAMURA, Hiroki NISHIKAWA, Ryo TAKATA, Kazunori YOH, Kunihiro HASEGAWA, Yukihisa YURI, Akio ISHII, Tomoyuki TAKASHIMA, Yoshiyuki SAKAI, Nobuhiro AIZAWA, Naoto IKEDA, Yoshinori IWATA, Hiroko IIJIMA, Shuhei NISHIGUCHI

P-89 AnalysisofDynamicChangeinSerumLowDensityLipoprotein-CholesterolLevelduringHepatitisCInterferon-freeTreatmentSatoru HASHIMOTO, Kohei HAYASHI, Yuki KUGIYAMA, Shigemune BEKKI, Shinjiro UCHIDA, Akira SAEKI, Shinya NAGAOKA, Seigo ABIRU, Kazumi YAMASAKI, Atsumasa KOMORI, Hiroshi YATSUHASHI

P-90 Impactofinter-individualdifferenceofCYP3AactivityinDAAtreatmentsTadashi IKEGAMI, Akira HONDA, Shoichiro YARA, Naoki KONISHI, Masashi MURAKAMI, Tadakuni MONMA, Takeshi HIRAYAMA, Junichi IWAMOTO, Teruo MIYAZAKI, Yasushi MATSUZAKI

P-91 Selectionofdirect-actingantiviraltreatmentforachievingasustainedviralresponseAyumi SUGIURA, Satoru JOSHITA, Tomoo YAMAZAKI, Naoyuki FUJIMORI, Soichiro SHIBATA, Yuki ICHIKAWA, Michiharu KOMATSU, Akihiro MATSUMOTO, Takeji UMEMURA, Eiji TANAKA


POSTERS

P-92 LiverStiffness-SpleenSize-to-PlateletRatioRiskScoreIdentifiesEsophagealVaricesinChronicLiverDiseaseSatoru JOSHITA, Soichiro SHIBATA, Takeji UMEMURA, Ayumi SUGIURA, Tomoo YAMAZAKI, Naoyuki FUJIMORI, Yuki ICHIKAWA, Michiharu KOMATSU, Akihiro MATSUMOTO, Eiji TANAKA

P-93 ControlledattenuationparameterforthediagnosisofsteatosisinchronichepatitisCNaoto KAWABE, Naohiro ICHINO, Senju HASHIMOTO, Michihito MURAO, Takuji NAKANO, Toshiki KAN, Kazunori NAKAOKA, Masashi OHKI, Yuka OCHI, Tomoki TAKAMURA, Sayuri NOMURA, Aiko FUKUI, Toru NISHIKAWA, Keisuke OSAKABE, Kentaro YOSHIOKA

P-94 Therapeuticeffectofdirect-actingantiviralsonhepatitisCvirusreinfectionafterlivertransplantationSatoshi MIUMA, Hisamitsu MIYAAKI, Ryu SASAKI, Yuri MIYAZOE, Shinobu YAMAMICHI, Mio YAMASHIMA, Suguru NAKASHIKI, Tomohiro SUEHIRO, Hidetaka SHIBATA, Naota TAURA, Kazuhiko NAKAO

P-95 AutotaxinisanovelmarkerforliverfibrosisinpatientswithchronichepatitisCTomoo YAMAZAKI, Satoru JOSHITA, Takeji UMEMURA, Yoko USAMI, Naoyuki FUJIMORI, Ayumi SUGIURA, Soichiro SHIBATA, Yuki ICHIKAWA, Michiharu KOMATSU, Akihiro MATSUMOTO, Eiji TANAKA

P-96 SerumADAMTS13antigenlevelisassociatedwiththeriskofhepatocellularcarcinomainJapanesepatientswithhepatitisCvirusKazumi YAMASAKI, Hitoshi IKEDA, Shigemune BEKKI, Yuki KUGIYAMA, Shinjiro UCHIDA, Satoru HASHIMOTO, Akira SAEKI, Shinya NAGAOKA, Seigo ABIRU, Atsumasa KOMORI, Hiroshi YATSUHASHI

P-97 Tolerabilityofsofosbuvir-basedtherapyforagedpatientswithchronichepatitisCRyotaro SAKAMORI, Tomohide TATSUMI, Takayuki YAKUSHIJIN, Ryoko YAMADA, Naoki MORISHITA, Yuki TAHATA, Ayako URABE, Kunimaro FURUTA, Hayato HIKITA, Hideki HAGIWARA, Naoki HIRAMATSU, Yukinori YAMADA, Yasuharu IMAI, Norio HAYASHI, Tetsuo TAKEHARA

P-98 Resistance-associatedvariantsduringretreatmentwithdaclatasvir/asunaprevirfollowingthefailureofsimeprevir-basedtripletherapyamongthepatientswithchronichepatitisCRyotaro SAKAMORI, Tomohide TATSUMI, Takayuki YAKUSHIJIN, Ryoko YAMADA, Naoki MORISHITA, Yuki TAHATA, Ayako URABE, Kunimaro FURUTA, Hayato HIKITA, Atsushi HOSUI, Naoki HIRAMATSU, Eiji MITA, Shinji TAMURA, Yasuharu IMAI, Tetsuo TAKEHARA

P-99 AdditionofRibavirintoDaclatasvirPlusAsunaprevirforChronicHepatitisC1bPatientswithBaselineNS5AResistance-AssociatedVariantsImprovingResponseRatePei-Jer CHEN, Chun-Ming HONG, Chun-Jen LIU, Shiou-Hwei YEH

P-100 Toinvestigatethetherapeuticstrategyofhugehepatocellularcarcinoma( ≧ 10cm);thecomparisonbetweenthesurgicalandthenon-surgicaltreatmentNorihiko YAMAMOTO, Kazushi SUGIMOTO, Yasuaki TAMAI, Kyoko YOSHIKAWA, Suguru OGURA, Rumi MOROOKA, Ryosuke SUGIMOTO, Hideaki TANAKA, Hiroshi HASEGAWA, Motoh IWASA, Yoshiyuki TAKEI

Clinical research

152 / HCV 2016

POSTERS

POSTERS

P-101 PolymorphismintheinosinetriphosphatasegeneinfluencesthereductionofhemoglobinlevelsandribavirindoseduringsofosbuvirandribavirintherapyRitsuzo KOZUKA, Akihiro TAMORI, Hoang HAI, Yuga TERANISHI, Hiroyuki MOTOYAMA, Etsushi KAWAMURA, Atsushi HAGIHARA, Sawako UCHIDA-KOBAYASHI, Hiroyasu MORIKAWA, Masaru ENOMOTO, Yoshiki MURAKAMI, Norifumi KAWADA

P-102 RecurrenceofhepatocellularcarcinomaafterhepatitisCviruseradicationwithall-oralregimensinpatientswhounderwentcurativetreatmentsRyo NAKAGOMI, Ryosuke TATEISHI, Taijiro WAKE, Mizuki NISHIBATAKE, Naoto FUJIWARA, Masaya SATO, Tatsuya MINAMI, Kenichiro ENOOKU, Hayato NAKAGAWA, Yoshinari ASAOKA, Yuji KONDO, Kazuhiko KOIKE

P-103 TheusefulnessoffrequencyanalysisofHepatitisCvirusdrug-resistantmutationandselectingDAAsinconsiderationofresistantmutationIsao HIDAKA, Isao SAKAIDA

P-104 Resistant-associatedvariantsassociatedwithfailureofdualoraltherapywithDaclatasvirandAsunaprevirSeiichi MAWATARI, Akihiro MORIUCHI, Oki TANIYAMA, Haruka SAKAE, Sho IJUIN, Kazuaki TABU, Kohei ODA, Tsutomu TAMAI, Akio IDO

P-105 EfficacyofdualoraltherapywithasunapreviranddaclatasvirforelderlypatientswithhepatitisCTakashi HONDA, Masatoshi ISHIGAMI, Yoji ISHIZU, Teiji KUZUYA, Kazuhiko HAYASHI, Yoshiki HIROOKA, Tetsuya ISHIKAWA, Hidemi GOTO

P-106 HepatitisCviruseradicationbydaclatasvirandasunaprevirtherapycontributestorapidchangesincirculatinglipid/lipoproteinandapolipoproteinprofilesTakeshi CHIDA, Maho NAGASAWA, Erika MATSUNAGA, Jun ITO, Kazuyoshi OHTA, Shin SHIMOYAMA, Satoru YAMAZAKI, Hidenao NORITAKE, Kazuhito KAWATA, Tetsuro SUZUKI, Yoshimasa KOBAYASHI

P-107 TheefficacyofphlebotomytreatmentinpatientwithchronichepatitisCShoichi SASAKI, Kazushige NIREI, Hiroshi MATSUMURA, Hitomi NAKAMURA, Shunichi MATSUOKA, Mitsuhiko MORIYAMA

P-108 “OthelloHypothesis”InvolvedintheDevelopmentofVirologicFailureinPatientswithGenotype1bHCVShowingNo-RAVsYoshihito UCHIDA, Jun-ichi KOUYAMA, Kayoko NAIKI, Kayoko SUGAWARA, Yukinori IMAI, Nobuaki NAKAYAMA, Satoshi MOCHIDA

P-109 Theroleofalcoholmetabolism-relatedSNPintheprogressionofliverdiseaseintheHCV-patientsachievingviralclearanceShinya MAEKAWA, Natsuko NAKAKUKI, Mitsuaki SATO, Yuichiro SUZUKI, Masaru MURAOKA, Shuya MATSUDA, Yasuhiro NAKAYAMA, Taisuke INOUE, Minoru SAKAMOTO, Nobuyuki ENOMOTO


POSTERS

P-110 StagnationofhistologicalimprovementisapredictorofdevelopmentofhepatocellularcarcinomaafterhepatitisCviruseradicationHiroyuki MOTOYAMA, Akihiro TAMORI, Sawako UCHIDA, Yuga TERANISHI, Ritsuzou KOTSUKA, Etsushi KAWAMURA, Jyunnji HAGIHARA, Hiroyasu MORIKAWA, Yoshiki MURAKAMI, Masaru ENOMOTO, Norifumi KAWADA

P-111 Theefficacyandsafetyoftelaprevir-andsimeprevir-basedtripletherapiesforolderpatientswithchronichepatitisCSatoshi YAMAGIWA, Toru ISHIKAWA, Nobuo WAGURI, Soichi SUGITANI, Kenya KAMIMURA, Atsunori TSUCHIYA, Masaaki TAKAMURA, Hirokazu KAWAI, Shuji TERAI

P-112 Prevalenceofnon-primatehepacivirusinhorsesinMongoliaTomoko DATE, Masaya SUGIYAMA, Damdindorj LKHAGVASUREN, Tsendsuren OYUNSUREN, Takaji WAKITA, Masashi MIZOKAMI

P-113 TheroleofmicroRNA-210-3pinhepatitisBvirus-relatedhepatocellularcarcinomaAsahiro MORISHITA, Hisakazu IWAMA, Koji FUJITA, Teppei SAKAMOTO, Takako NOMURA, Joji TANI, Hirohito YONEYAMA, Tsutomu MASAKI

P-114 Significanceofhepaticprogenitorcellmarker-positivehepatocellularcarcinomaanditspossiblepredictionbyAFP-L3Atsunori TSUCHIYA, Yuichi KOJIMA, Satoshi SEINO, Yusuke WATANABE, Yuzo KAWADA, Shunzo IKARASHI, Suguru TAKEUCHI, Toru SETSU, Akira SAKAMAKI, Satoshi ABE, Kenya KAMIMURA, Masaaki TAKAMURA, Kawai HIROKAZU, Satoshi YAMAGIWA, Shuji TERAI

P-115 Recenttrendinreal-worldanti-viraltreatmentoptionsforgenotype1bchronichepatitisCinJapanKenichi IKEJIMA, Kyoko FUKUHARA, Tomonori AOYAMA, Akira UCHIYAMA, Kazuyoshi KON, Shunhei YAMASHINA, Sumio WATANABE

P-116 CombinationtherapywithDaclatasvirandasunaprevirforthepatientsinfectedwithHCVgenotype1Masakuni TATEYAMA, Motohiko TANAKA, Takehisa WATANABE, Hiroko SETOYAMA, Takeyasu KOUNOE, Yoshinari SAKAI, Masato SASAKI, Kazuhiro SUGI, Shiho MIYASE, Shigetoshi FUJIYAMA, Yutaka SASAKI

P-117 Ledipasvir/SofosbuvirdecreasesriskfactorsassociatedwithhepatocellularcarcinomainpatientswithchronichepatitisCMasaaki KORENAGA, Keiko KORENAGA, Tatsuya KANTO, Masashi MIZOKAMI

P-118 ClinicaloutcomesofpatientswithhepatitisCvirus-relatedhepatocellularcarcinomaobtainingviraleradicationafterinterferontherapyMotohiko TANAKA, Yoko YOSHIMARU, Takayuki TOKUNAGA, Takeshi KAWASAKI, Satomi FUJIE, Takayoshi SONODA, Takehisa WATANABE, Hiroko SETOYAMA, Masakuni TATEYAMA, Yutaka SASAKI

Clinical research


POSTERS

P-119 ActivationofproteinkinaseRbyhepatitisCvirusRNA-dependentRNApolymeraseRyosuke SUZUKI, Mami MATSUDA, Takashi SHIMOIKE, Koichi WATASHI, Hideki AIZAKI, Takanobu KATO, Tetsuro SUZUKI, Takaji WAKITA

P-120 ImmunotherapeuticeffectsandalteredcellmetabolismbythenewlyidentifiedagenttargetingtheGWAS-discoveredsusceptibilitygeneforHCV-HCCKaku GOTO, Wenwen LI, Sayaka ITO, Jun ARAI, Anthony STEPHANOU, Ryosuke MUROYAMA, Yasuo MATSUBARA, Ryo NAKAGAWA, Yasushi TANOUE, Sayuri MORIMOTO, Yoshimi KAISE, Lay LIM, Masahisa JINUSHI, Naoya KATO

P-121 IFN- λ 4potentlyblocksIFN- αsignalingbyISG15andUSP18inHCVinfectionEui-Cheol SHIN, Pil Soo SUNG, Hong SEON-HUI, Park SU-HYUNG

P-122 HepatitisCvirusistargetedbynaturalkillercellsthroughtheinductionofNKG2Dligandinhumannon-neoplastichepatocytecellsHiromichi DANSAKO, Hiroki HIRAMOTO, Youki UEDA, Shinya SATOH, Nobuyuki KATO

P-123 CleavageofMAVSandinterferencewithinnate-immunesignalingisconservedamonghepaciviralNS3/4AproteasesThomas PIETSCHMANN, Angga KUSUMA, Richard JP BROWN, Dominic H BANDA, Gabrielle VIEYRES, Michael ENGELMANN, Eike STEINMANN

P-124 SelenoproteinP,aliver-derivedsecretoryprotein,regulatesRIG-I-mediatedinnateimmunityinhepatocytesKazuhisa MURAI, Masao HONDA, Tetsuro SHIMAKAMI, Takayoshi SHIRASAKI, Hirofumi MISU, Toshinari TAKAMURA, Stanley M LEMON, Seishi MURAKAMI, Shuichi KANEKO

P-125 TumorNecrosisFactor- αinhibitsHCVspreadindependentlyofinterferonsStephen M LAIDLAW, Svetlana MARUKIAN, Rachel GILMORE, Siobhán B CASHMAN, Charles M RICE, Lynn b DUSTIN

P-126 HepatitisCVirusNonstructural5AInhibitsTypeIIFN- β -inducedAntiviralImmunitybyTargetingtheIKK ε /DDX3ComplexByeong-Sun CHOI, Sang-Min KANG, Ji-Young PARK, Ju-Yeon CHOI, Chun KANG

P-127 Longnon-codingRNA#32conferstoantiviralresponsesbycontrollinginterferon-stimulatedgeneexpressionHironori NISHITSUJI, Saneyuki UJINO, Kunitada SHIMOTOHNO

P-128 HepatitisCvirusreplicativedouble-strandedRNAisapotentinterferoninducerthattriggersinterferonproductionthroughMDA5Zhigang YI, Xiaoting DU, Zhenghong YUAN

P-129 Activity-basedproteinprofilingoftheroleof25-hydroxycholesterolandmiRNA-185intheimmunometabolicresponsetoHepatitisCinfectionRoxana FILIP, Genevieve DESROCHERS, John P PEZACKI

Innate immunity

180 / HCV 2016

POSTERS

POSTERS

P-130 TwodifferentrolesofISG15inHCVinfectionIkuo SHOJI, Nanae MINAMI, Chieko MATSUI, Tutik Sri WAHYUNI, Lin DENG

P-131 Monocytes-derivedGalectin-9activatesNKcellsinchronichepatitisCTomohide TATSUMI, Akira NISHIO, Takahiro SUDA, Tadashi KEGASAWA, Seiichi TAWARA, Teppei YOSHIOKA, Satoshi AONO, Minoru SHIGEKAWA, Hayato HIKITA, Ryotaro SAKAMORI, Tetsuo TAKEHARA


POSTERS

P-132 ComprehensiveAnalysisofHumanHepatitisCVirusSpecificTCellResponsesinthePresenceorAbsenceofDirect-actingAntiviralTherapyChao ZHANG, Rui HUA, Yuanyuan CUI, Shasha WANG, Yonghong ZHANG, Zhengkun TU, Pei HAO, Xinyue CHEN, Jin ZHONG, Junqi NIU, Xia JIN

P-133 ATCF1+memory-likepopulationofHCV-specificCD8+T-cellsismaintainedafterDAA-mediatedantigenwithdrawalDominik WIELAND, Anita SCHUCH, Janine KEMMING, Dietmar ZEHN, Werner HELD, Christoph NEUMANN-HAEFELIN, Maike HOFMANN, Robert THIMME

P-134 ImmunogenicityofhighlyconservedE2epitopeofHCVexposedonthesurfaceofLeishmania-derivedhepatitisBsmallantigenparticlesAnna CZARNOTA, Jolanta TYBOROWSKA, Grażyna PESZYŃSKA-SULARZ, Beata GROMADZKA, Krystyna BIEŃKOWSKA-SZEWCZYK, Katarzyna GRZYB

P-135 Lowquasispeciesdiversity:anewriskfactorassociatedwithverticaltransmissionofhepatitisCvirusAriane LAROUCHE, Armelle LE CAMPION, Virginie CALDERON, Sébastien FAUTEUX-DANIEL, Kimberly Ann MILTON MCSWEEN, Marc BOUCHER, Normand LAPOINTE, Mel KRAJDEN, Deborah M. MONEY, Hugo SOUDEYNS

P-136 ReversalofperipheralandintrahepaticHCV-specificCD8+TcellexhaustionafterremovalofcognateantigenPierre TONNERRE, Jihad AL-JABBAN, Damien TULLY, David BEAN, Joelle BROWN, David WOLSKI, Almudena TORRES-CORNEJO, Maxwell ROBIDOUX, Daniel KVISTAD, Jenna GUSTAFSON, Jasneet ANEJA, Todd ALLEN, Raymond T CHUNG, Arthur Y KIM, Georg M LAUER

P-137 Multipleflavivirusesneutralizationassaybasedonsingle-roundinfectiousparticlesMami MATSUDA, Atsushi YAMANAKA, Kentaro YOSHII, Koichi WATASHI, Hideki AIZAKI, Eiji KONISHI, Tomohiko TAKASAKI, Takaji WAKITA, Ryosuke SUZUKI

P-138 CommitmenttoCD8+TcellexhaustionandlossofmemoryTcellpotentialdevelopsduringprimarychronicHCVinfectionMehdi RASOLI PIROZYAN, Preston LEUNG, Auda ELTAHLA, Simone RIZZETTO, Oanh NGUYEN, Katherine KEDZIERSKA, Andrew LLOYD, Rowena BULL, Fabio LUCIANI

P-139 DeepsequencingandfunctionalanalysisofHCVbroadlyneutralizingantibodyAR3CErick GIANG, Linling HE, Jiang ZHU, Mansun LAW

P-140 CpGoligonucleotidescomplexedwithdectin-1ligandenhanceshumoralandcellularimmuneresponsetoHBVvaccineHiroyasu ITO, Motohiro NAKAMURA, Hidekazu ISHIDA, Kouji KOBIYAMA, Takuya YAMAMOTO, Ken J. ISHII, Mitsuru SEISHIMA, Tetsuya ISHIKAWA

P-141 GlobalMappingofAntibodyRecognitionoftheHepatitisCVirusE2Glycoprotein:ImplicationsforVaccineDesignBrian G. PIERCE, Zhen-yong KECK, Catherine FAUVELLE, Ragul GOWTHAMAN, Thomas R FUERST, Roy A MARIUZZA, Thomas F BAUMERT, Steven KH FOUNG

Adaptive immunity


POSTERS

P-142 Functionalhomologyofhepacivirus5’UTRsinIRESactivityandreplicationTomohisa TANAKA, Teruhime OTOGURO, Atsuya YAMASHITA, Hirotake KASAI, Kohji MORIISHI

P-143 ComparativestudyofinvivoevolutionofhepaciviralglycoproteinsinhumansandhorsesThomas PIETSCHMANN, Daniel TODT, Richard JP BROWN, Stephanie WALTER, Juliane DOERRBECKER, Stephanie PFAENDER, Heiner WEDEMEYER, Eike STEINMANN

P-144 InnateAntiviralImmuneResponsestoHepatitisVirusesinTupaiabelangeriMohammad E. H. KAYESH, Sayeh EZZIKOURI, Haiying CHI, Takahiro SANADA, Naoki YAMAMOTO, Bouchra KITAB, Aya MATSUU, Hitoshi HATAI, Noriaki MIYOSHI, Michinori KOHARA, Kyoko TSUKIYAMA-KOHARA

P-145 TheRoleofHepatitisCVirusCapsidProteininthePreservationandNuclearTranslocationofPhospho-IkBalphaWesley WILLIAMS, Julia WEISBROD, Tracy BUSHUR, Steven ZAMORA, Roland WOLKOWICZ

P-146 Bothselectionfromquasispeciesandnewmutationduringtreatmentareinvolvedinemergingresistance-associatedsubstitutionofHCVafterDAAtreatmentHayato HIKITA, Yugo KAI, Tomohide TATSUMI, Naoki MORISHITA, Ryoko YAMADA, Takayuki YAKUSHIJIN, Yasuteru KONDO, Takanobu KATO, Hiroshi SUEMIZU, Ryotaro SAKAMORI, Tetsuo TAKEHARA

P-147 ExaminationasthehepatocytescarcinogenesismodelofthePLC/PRF/5cellstrainTomohiro KANEKO, Shouichi SASAKI, Tomotaka ISHII, Katsutoshi SHIBATA, Mitsuhiko MORIYAMA

New model


POSTERS

P-148 NovelAnti-HepatitisCVirusActivityofSpatholobusSuberectusYing WANG, Shao-Ru CHEN, An-Qi WANG, Li-Gen LIN, Yi-Tao WANG

P-149 EvaluationofAntiviralActivitiesofVitaminDDerivativesinHepatitisCVirusLifecycleAsako MURAYAMA, Nao SUGIYAMA, Takaji WAKITA, Takanobu KATO

P-150 Identificationandcharacterizationofhumanmonoclonalanti-HCVantibodiesclonedfromchronichepatitisCpatientsHiroshi YOKOKAWA, Midori SHINOHARA, Noriko NAKAMURA, Tomokatsu IWAMURA, Tomohiko SUZUKI, Takaji WAKITA

P-151 MitochondriaF1-F0ATPsynthasefacilitatesdenguevirusreplicationandservesasapotentialtargetfordevelopingantiviralagentsChin-Kai TSENG, Chun-Kuang LIN, Yu-Hsuan WU, Kung-Chia YOUNG, Jin-Ching LEE

P-152 Anti-hepatitisCviruscompoundsfromRuta angustifoliamediateasynergisticeffectincombinationwithcurrentdirect-actingantiviralagentsTutik Sri WAHYUNI, Aty WIDYAWARUYANTI, Maria Inge LUSIDA, Achmad FUAD, Lin DENG, Chieko MATSUI, Hiroyuki FUCHINO, Nobuo KAWAHARA, Ikuo SHOJI, Hak HOTTA

P-153 USP18interactswithHCVcoreproteintoinhibitthecore-inducedactivationofJak/STATsignalingpathway:implicationsforviralpersistenceXuezhen SHI, Shilin LI, Limin CHEN

P-154 Antiviralactivitiesofthescorpine-likepeptideSmp76isolatedfromScorpio maurus palmatusagainstdenguevirusandhepatitisCvirusHak HOTTA, Alaa A. EL-BITAR, Moustafa M. SARHAN, Mohamed A. RAHMAN, Lourival D. POSSANI, Ming CHEN, Lin DENG, Chie A. UTSUBO

P-155 NaturalproductLHextractedfromFormosansoftcoralsuppresseshepatitisCvirusreplicationthroughreducingtheMAPK-JNK/c-Jun-C/EBP-regulatedcyclooxygenase-2expressionWei Han CHEN, Chun-Kuang LIN, Chin-Kai TSENG, Yu-Hsuan WU, Chih-Chuang LIAW, Jin-Ching LEE

P-156 TargetedScreeningforAnti-HepatitisCVirusCompoundsviaUltraHigh-ThroughputScreeningJun-Wei LEE, Luh TUNG, Tien-Hsien CHANG

P-157 DevelopmentoftoolstoinvestigateresistanceofhepatitisCvirusgenotype3todirectactinginhibitorsofnonstructuralprotein5ALorna J KELLY, Jack SILBERRAD, Anjna BADHAN, Jean Lutamyo MBISA, Mark HARRIS

P-158 Cultivatedcell-basedevaluationofapolipoproteinswiththetreatmentofdirect-actingantiviralagentsagainsthepatitisCvirusinfectionChen Wei TSAI, Yu Hung SUN, Ying Chiung TSENG, Nan Pin CHENG, Cheng Yen CHIU, Tsung Ting CHANG, Chia Kung YOUNG

Drug and vaccine development

204 / HCV 2016

POSTERS

POSTERS

P-159 CelastrolinhibitshepatitisCvirusactivitybyinducinghemeoxygenase-1throughthenuclearfactorerythroid2-relatedfactor2pathwayHsing-Ju WU, Li-Chuan LIN, Jin-Ching LEE

P-160 TowardsascalableHCVvaccine:PurificationandimmunogenicityofafunctionalgpE1/gpE2heterodimerisolatedfromanFcdomaintaggedprecursorMichael R LOGAN, John LAW, Jason Alexander Ji-Xhin WONG, Darren HOCKMAN, Amir LANDI, Chao CHEN, Kevin CRAWFORD, Juthika KUNDU, Lesley BALDWIN, Janelle JOHNSON, Anita DAHIYA, Gerald LACHANCE, Lorne TYRRELL, Michael HOUGHTON

P-161 Signalpeptidepeptidaseasatargetforanti-HCVdrugToru OKAMOTO, Junki HIRANO, Tatsuya SUZUKI, Shinji KUSAKABE, Takasuke FUKUHARA, Kohji MORIISHI, Kazuhiko KOIKE, Yoshiharu MATSUURA

P-162 RoleoflipiddropletsintheemergenceofdrugresistantvirusagainstdirectactingantiviralsHirofumi OHASHI, Syo NAKAJIMA, Sulyi KIM, Ryosuke SUZUKI, Hideki AIZAKI, Masayoshi FUKASAWA, Shinji KAMISUKI, Fumio SUGAWARA, Naoko OHTANI, Takaji WAKITA, Koichi WATASHI

P-163 Liver-specificmono-unsaturatedfattyacidsynthase-1inhibitorasoneoptionforanti-hepatitisCtreatmentHikari HASEGAWA, Yasunori NIO, Hitomi OKAMURA, Yohei MIYAYAMA, Yuichi AKAHORI, Makoto HIJIKATA

P-164 SynergisticInhibitionofHCVReplicationbyCombinationofaPRK2InhibitorandDirect-actingAntiviralsBo-Yeong PAK, Jae-Su MOON, Seung-Hoon LEE, Jong-Won OH

P-165 ImmunizationwithcocktailsofchimericHBV-HCVparticlesbearingHCVenvelopesfromdifferentgenotypeselicitsbroadlycross-neutralizingantibodyresponsesElodie E.B. BEAUMONT, Clement B.C. BENOIT, Guerin V.G. VANESSA, Chopin L.C. LUCIE, Roingeard P.R. PHILIPPE

P-166 Broadlyactiveantiviralswithanaturallyderivedchelatingmoietytargetinghepaci-andflavivirusreplication;furtherevaluationunderlivernormoxicconditionsEfseveia FRAKOLAKI, Erofili GIANNAKOPOULOU, Vassilios MYRIANTHOPOULOS, Marios DIMITRIOU, Vanessa MADAN, Emmanouel MIKROS, Ralf BARTENSCHLAGER, Penelope MAVROMARA, Grigoris ZOIDIS, Niki VASSILAKI

P-167 Proteaseinhibitor-,concentration-andgenotype-dependentdistributionofNS3resistancesubstitutionsinHCVgenotype1-6populationstreatedwithgrazoprevirandparitaprevirSanne B. JENSEN, Ulrik FAHNOE, Qi TANG, Lubna GHANEM, Santseharay RAMIREZ, Daryl HUMES, Long VAN PHAM, Stephanie SERRE, Jens BUKH, Judith GOTTWEIN


POSTERS

P-168 TheDiscoveryandDevelopmentofanAryloxazoleClassofCompoundsasaHepatitisCVirusEntryInhibitorZongyi HU, He SHANSHAN, Derek LE, Kelin LI, Xin HU, Amy WANG, Marc FERRER, Noel SOUTHALL, Jeffrey AUBÉ, Frank J SCHOENEN, Kazuaki CHAYAMA, Juan J MARUGAN, Kevin J FRANKOWSKI, T. Jake LIANG

P-169 GuanfacineinhibitshepatitisCvirusRNAreplicationMidori TAKEDA, Nobuyuki KATO, Masanori IKEDA

P-170 ACRIDONEFAC4EFFICIENTLYINHIBITSINVITROREPLICATIONOFHEPATITISCVIRUSPaula RAHAL, Campos R. F. GUILHERME, Ana Carolina G. JARDIM, Jacqueline F. SHIMIZU, Mariana N. BATISTA, Eder R. PAGANINI, Mark HARRIS, Luis O. REGASINI, Cintia BITTAR

P-171 HECATEANDITSN-TERMINUSDERIVATIVESINHIBITENTIREHCVREPLICATIONCYCLENON-GENOTYPESPECIFICPaula RAHAL, Mariana Nogueira BATISTA, Paulo Ricardo da Silva SANCHES, Ana Cláudia Silva BRAGA, Guilherme Rodrigues Fernades CAMPOS, Eduardo Maffudi CILLI, Bruno Moreira CARNEIRO

P-172 OptimumcellularandhumoralimmuneresponseselicitedbyahepatitisCvirusE1E2vaccineadjuvantedwithcyclic-di-adenosinemonophosphateandarchaesomesAbdolamir LANDI, John LAW, Darren HOCKMAN, Michael LOGAN, Kevin CRAWFORD, Chao CHEN, Juthika KUNDU, Carlos A. GUZMAN, Lise DESCHATELETS, Lakshmi KRISHNA, Lorne TYRRELL, Michael HOUGHTON

P-173 Developmentofanti-HCVdrugcandidatestargetingNS5AMd Shafiqur RAHMAN, Hee Sun KIM, Il Hak BAE, Youngsu YOU, Byung Moon KIM, Michinori KOHARA, Sung Key JANG

P-174 PropertiesofneutralizingantibodieselicitedbyaHCVvaccinecandidateJason A WONG, Michael LOGAN, Darren HOCKMAN, Rakesh BHAT, Chao CHEN, Aviad LEVIN, Abdul KHAN, Jillian WHITBY, Joseph MARCOTRIGIANO, Sharon FREY, Robert BELSHE, D. Lorne TYRRELL, John LAW, Michael HOUGHTON

P-175 DevelopmentofNovelAnti-viralAgentsagainstHepatitisBVirusbyusingansiRNAScreeningPanelTargetingtheCarbohydrateSynthesisSystemKiyoaki ITO, Masashi YONEDA, Kiyohiko ANGATA, Koichi WATASHI, Takaji WAKITA, Yasuhito TANAKA, Masashi MIZOKAMI, Hisashi NARIMATSU

P-176 ConjugationofHCVE2envelopeproteinwithferritinformsananoparticlevaccinewithimprovedantigenicitythatefficientlyinducesneutralizingantibodiesXuesong WANG, Yu YAN, Dapeng LI, Jin ZHONG, Zhong HUANG

Drug and vaccine development

206 / HCV 2016

POSTERS

POSTERS

P-177 EstablishmentofthemethodforevaluatingmolecularinteractionbetweenhepatitisBvirusentryinhibitorsandsodiumtaurocholatecotransportingpolypeptideKento FUKANO, Satomi SHIMURA, Michael PEEL, Ann SLUDER, Fumihiro KAWAI, Senko TSUKUDA, Ryosuke SUZUKI, Hideki AIZAKI, Sam-Yong PARK, Takaji WAKITA, Yuki OGASAWARA, Koichi WATASHI

P-178 PopulationPharmacokineticAnalysisofLedipasvir/SofosbuvirinJapaneseSubjectswithChronicGenotype1HCVInfectionYoshiyuki UENO, Kimberly L GARRISON, Bing GAO, Phil PANG, Steven KNOX, Anita MATHIAS

P-179 EndoplasmicReticulumStressLinksHepatitisCVirusRNAReplicationtoWild-TypePGC-1 α /Liver-SpecificPGC-1 αUpregulationWenxia YAO, Hua CAI, Xinlei LI, Ting LI, Longbo HU, Tao PENG

virus entry - c-linkage.co.jpryosuke suzuki, hideki aizaki, fumio sugawara, naoko otani, takaji...

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