vii edizione capri pediatria capri, 28 – 30 aprile 2014 biomarkers nell’asma bronchiale...
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VII edizione Capri PediatriaCapri,28 – 30 Aprile 2014
Biomarkers nell’asma bronchiale
Guglielmo ScalaNapoli
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Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
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Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
La cellula Th2 è fondamentale per la maturazione dell’eosinofilo
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Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
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A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
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A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
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Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008 Nasce il
concetto di EMTU
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Lamina basale è prodotta dalle cell epiteliali
Lamina reticolare (MBR) è prodotta dai fibroblasti
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A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
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Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatmentP. Holt & P. Sly, Nature Medicine, 2012
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Holt & Sly, Nat Med 2012
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Holt & Sly, Nat Med 2012
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Holt & Sly, Nat Med 2012
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Holt & Sly, Nat Med 2012
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Holt & Sly, Nat Med 2012Smascherata la marcia atopica??
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The basics of epithelial-mesenchymal transitionKalluri R, Weinbergjj R , J Clin Invest. 2009.
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The basics of epithelial-mesenchymal transitionKalluri R, Weinbergjj R , J Clin Invest. 2009.
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A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.
Khayyal MT 2003, Fundam Clin Pharmacol
FVC + 19%
FEV1 +30%
PEFR +30%
FEF 25-75 +41%
TNF -52%
ICAM-1 -65%
IL-6 -44%
IL-8 -30%
IL-10 +300%
Asma notturno/settimana - 60 %
22 pazienti : placebo24 pazienti : propoli
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Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity Machado JL et al, 2012, Evidence-Based Compl Altern Med
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Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells
Wang et al, 2009, Clin Exp Immunol
The inhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells
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Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne
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Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol
TGF- bAlterazioni morfologiche↓ E - cadherin↑ N - cadherin↑ ROS↑ motilità cellulare
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation.
Kao HF, et al. 2013, Int Immunopharmacol
TGF- bAlterazioni morfologiche↓ E - cadherin↑ N - cadherin↑ ROS↑ motilità cellularePROPOLI
Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol
The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma