viewpoint in leptospirosis - ministry of public...
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VIEWPOINT IN LEPTOSPIROSIS
VISITH SITPRIJA
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LEPTOSPIROSIS : DIRECTION
•• TemperatureTemperature•• OsmolalityOsmolalityOsmolalityOsmolality•• ElectrolytesElectrolytes•• pHpH•• TaxonomyTaxonomy--GenomeGenomeLeptospires •• TaxonomyTaxonomy--GenomeGenome
P t tP t t
Animals Man
•• Prevent entryPrevent entry•• VaccineVaccine•• Early diagnosisEarly diagnosisAnimals Man •• Early treatmentEarly treatment
DiseaseDisease Non diseaseNon disease
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PathophysiologyPathophysiology TreatmentTreatment
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ION CHANNEL FUNCTION
Immunity
Neuromuscular function
T itt d hTransmitters and hormones
Cell volume regulationCell volume regulation
Cell growth
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CaCa Na Na NaKNaK-- ATPaseATPase
NaNaCaCa KK KK KKENaCENaC CaCa
NaNa
KKVV KKATPATP KKCaCaKKKK
NaNaHH
NHENHE ClClHCOHCO33
ClClNaNa
ClCl NaNa KKClClCFTRCFTR AQPAQPClCl ClCl
NCCNCC
NaNa KK
NKCLNKCL
CFTRCFTRCaCCCaCC AQPAQP
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NCCNCC NKCLNKCL
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INFLAMMATION - HYPOXIA
Loss of polarity
Channel dysfunction
Di ti f ll l j tiDisruption of cellular junction
Channel openingp g
Cell swelling
Cell death
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RESPIRATORY SYSTEM
Channels Cytokines
ENaC* TNF IL 1 TGF IL 4ENaC* TNF, IL-1β, TGFβ1, IL-4
NKCC*
CFTR IFNγ, TGF
CFTR IL-1, IL-4
AQPAQP1, 5
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GASTROINTESTINAL TRACT
Channels Cytokines
CFTR IL-1β, IL-3, TNF, Subs.P
ENaC TNF IL 1 IFNγENaC TNF, IL-1, IFNγ
NKCC TNF, IFNγγ
NaK-ATPase TNF, IFNγ, TGF
APQ2, 3
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KIDNEY Channels Cytokines
ENaC Bradykinin
NKCC*NKCC*
NaK-ATPase Bradykinin, IL-1β, NO, PGE2NaK ATPase Bradykinin, IL 1β, NO, PGE2
AQP2*
NHE*
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INFECTION
Modulation of ion channelsModulation of ion channels
Role of cytokines and mediators
Severity of infection
S f fSpecificity of toxin
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