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    Venture Capital Activity Report | Q4 2011

    www.cbinsights.com

    QUARTER SUMMARY 2

    QUARTERLY TRENDS 3

    SECTOR REVIEW 11

    1 INTERNET 11

    2 HEALTHCARE 18

    3 GREEN / CLEAN TECH 25

    GEOGRAPHIC REVIEW

    1 CALIFORNIA 32

    2 MASSACHUSETTS 38

    3 NEW YORK 43

    4 WASHINGTON 49

    5 TEXAS 54

    DEFINITIONS & DATA INTEGRITY 59

    TABLE OF CONTENTS

    2012, CB Insights. All rights reserved. For more information about CB Insights, please email [email protected].

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    Q4 2011 This Quarter in Venture CapitalBam! 2011 VC investment and deal totals mark highest seen in 10 years. Talk ofbubble begins in 3, 2, 1..

    2

    VCs werent bashful in Q4 2011 showering 755 companies with $7.6 billion in venture funding. Q4s performance brought2011s total to $30.6B invested in 3051 deals which marked a 10-year high for the VC asset class on both deals and dollars

    The Fat VC FunnelSo with 2011s results, the bubble talk will shift intooverdrive. The reality is that VC funding is a funnel. Morecompanies get Series A than B than C etc, etc. Withintech, our data shows the VC funnel has gotten fat at thetop (a lot of Series A and Seed deals). And VCDarwinism means that not all of these companies can orshould receive Series B, C, etc. While some would saythis is the way markets work, for a company raisingmoney, this can represent a chokepoint. Some willreceive funding, some will die quickly, some will get acq-hired or get dressed up as acquisitions, some will beorphaned and figure out a way to make money andbecome steady businesses and some will die a slower,more tortured death.

    New York Back to Reality or a Speed Bump?One quarter does not a trend make. So after taking the

    #2 spot for aggregate VC deals and dollars in Q311, NYslipped back to #3 behind Massachusetts. The stateretains its hold on #2 for tech deals and dollars andshowed some life in the healthcare realm as well. Wellsee if NY can fight back like its resilient football Giants orwhether the state will just talk incessantly and not performlike the Jets in future quarters.

    Healthcare VC Rumors of Death Greatly Exaggerate

    Healthcare hit a five quarter high on funding and showedsolid deal activity. Sector reverses downward trend andshows pulse to close out 2011.

    Massachusetts Balanced Attack Brings It Back to #2

    Massachusetts took back its #2 spot for both deals anddollars with deals across multiple sectors. Healthcarewas particularly strong. Internet investment in the statewas the one weak spot in an otherwise strong showing.

    Internet Takes 1/3 of VC Dollars in 2011Cali and NY account for 59% of internet VC deals and66% of funding. Internet investments took over 1/3 ofventure dollars in 2011. Massachusetts fell to a fivequarter low on internet deal share. Mega-deals in thedata storage (Dropbox and Box.net) buoy funding.

    California Steady as Ever.Cali still the top spot for VC deals and dollars. Nuff said

    Washington Stalls. Again.Well bring back our Sleeping in Seattle metaphor asWashington continued its multi-quarter dealflow slide analso came down on funding.

    Only deals in which VCs are participating are included. Companies which raise money from mutual or private equity fundsor corporations (unless it is their corporate venture arms) are not included. We recommend you review our definitions and

    methodology on p. 59 to see what is included/excluded as there is a great amount of misinformation out there.

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    $7.6B over 755 DealsQ4 Continues 2011s Torrid PaceQ4 11 was slower than recent quarters but continued 2011s strong VC performance.2011 reaches $30.6B in total venture funding marking 10 year high.

    3

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    Back to Reality? Mass Deal Share Eclipses NYNYs rise to #2 was short-lived as Mass regains its #2 spot on deals. Cali, Mass andNY continued to own 60+% share of deals.

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    Cali Dominates. Mass & Cali Take 65% of VC DollarsNY funding share dipped back to historical levels. California and Mass took significantshare of venture dollars with Texas registering a big quarter on back of big deals.

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    6

    What Smart Investors, Bankers andWealth Managers Use to Get AheadWith CB Insights you can access deep private company info that was once exclusivelyavailable behind prohibitively expensive paywalls.

    Coverage Universe

    Venture Capital 1999 to present Angel Investment

    Private Equity Federal SBIR Grants 3 years State Grant Programs Incubators Over 300 Middle Market Private Companies

    Sector Coverage

    Green/clean tech Internet Mobile & Telecom

    Software Energy & Utilities Computer Hardware & Services Healthcare Industrial Automotive & Transportation Business Products & Services Consumer Products & Services Electronics Environmental Services &

    Equipment Financial Services Food & Beverages Leisure Media Metals & Mining Retail Risk & Security

    CB Insights is accessible for free by visiting http://www.cbinsights.com

    82,000+ Private Company Profiles.

    Company & Investor Updates via Email.

    Add companies and investors ofinterest to your CBI Watchlist and getnotified of changes and updatesautomatically.

    Over 82,000 high value privatecompany profiles across industries andsectors. Medical devices tomobile. Industrial to internet.

    From Angel to Private Equity.

    Angel investment to venture capital toprivate equity to government funding tounder the radar mid-market privatecompanies.

    Management & Board Information

    Find out about the people behind thecompanies including management andboard of directors profiles.

    Analytics & Reporting

    Downloadable reports and analyticswhich allow you to manipulate datawhen and how you want to.

    http://www.cbinsights.com/http://www.cbinsights.com/
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    Venture Capital Activity Report | Q4 2011

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    So Much for VCs Going on Vacation in DecemberVCs ended the year strong with 264 deals. Every month of 2011 had more than 200deals and $2.2B invested marking a pretty consistent rate of activity for the full year.

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    The Series B and C Crunch? Yeah, Thats Looking LikelySeed and Series A were almost 50% of deals making Series B and beyond a potentialchokepoint for many companies raising early stage money.

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    Healthcare Deals and Dollars Show Some LifeAfter a three quarter slide on deals, healthcare investment regained in Q411. Mobileremained strong on both deals and dollars for a 2nd straight quarter.

    9

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    Get Started for Free with CB InsightsBasic membership on CB Insights is free. Just visit http://www.cbinsights.com. Orconnect with us via any of the following.

    Twitter

    Follow us @cbinsights

    Newsletter

    Click here to receive our weeklydealflow newsletter.

    Email

    [email protected]

    Telephone

    212-292-3148

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    INTERNET

    Q4 2011 Venture Capital

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    Internet Investment Comes Back to Earth After Torrid Q3Web companies took over $10.5B of venture funding in 2011 representing over 1/3 oftotal VC investment.

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    Quarter Highlights

    283 deals | $2,514M

    Top Deals

    Top Cities

    Cali Dominates Net Deals & Dollars and NY Solid at #2NYs thriving internet ecosystem holds strong and nearly doubles Mass on # of deals.Washington DC shows strength on dollars on back of LivingSocial mega-deal.

    San Francisco, CA

    53 deals | $564MNew York, NY

    40 deals | $362MWashington, DC

    6 deals | $207MAustin, TX

    5 deals | $164M

    Palo Alto, CA11 deals | $147MRedwood City, CA

    7 deals | $146MMountain View, CA

    10 deals | $89MSan Mateo, CA

    5 deals | $85MBoston, MA

    6 deals | $69MBurlingame, CA

    2 deals | $46M

    DropboxLivingSocialWhaleShark MediaBox.net

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    Deal/Dollar Share In Line With Historical LevelsNYs ascent of Q311 didnt continue, but the state still was the clear #2.Massachusetts falls to 5 quarter low on share of internet deals.

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    Seed and Series A Momentum Stays StrongSeed deals in web companies maintained record levels, and Series A showed anuptick. Series B and C deals both declined on deal share.

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    Dropbox and Box.net Garner Data Storage Big DollarsDeal and dollar distribution remains diverse with some new areas like businessintelligence, analytics and video showing deal strength.

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    Internet Medians Drop Across the BoardWhile not dramatically declining, the internet sector did see median deal values dropacross-the-board on a sequential basis.

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    HEALTHCARE

    Q4 2011 Venture Capital

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    What Healthcare VC Decline?After three quarters of declining deal volume, healthcare re-emerged with strongdealflow and the highest venture funding tally of the last five quarters.

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    Mass and Cali Retain Dominance of Healthcare SectorCalifornia and Massachusetts combine for 50% of deal share and 67% of dollars. Therest of the field is fragmented as is typical.

    Quarter Highlights

    172 deals | $1,895M

    Top Deals

    Top Cities

    Cambridge, MA13 deals | $262M

    San Diego, CA14 deals | $172M

    South San Francisco, CA3 deals | $106M

    Boston, MA

    4 deals | $80MRedwood City, CA

    2 deals | $74MGermantown, MD

    1 deals | $54MIrvine, CA

    3 deals | $51MNew York, NY

    3 deals | $47MWatertown, MA

    4 deals | $44MBurlingame, CA

    1 deals | $42M

    Portola PharmaceuticalsAgios PharmaceuticalsRempex PharmaceuticalsSensors for Medicine & Scien

    DermiraCleave Biosciences

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    Cali Slides to Five Quarter Low on Deal ShareOverall, venture deal and dollar share stays within its historical bounds.

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    Healthcare Sees Series A Deals Win the QuarterHealthcare VCs committed significant deal volume and funding to Series A deals.Series B was weak on both fronts. Is a Series B crunch which is discussed on thetech front also going to hit healthcare?

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    Medical Devices, Pharma and Biotech Rule Q4Medical devices continue their leading position for deals and dollars within theHealthcare sector, followed by strong quarters for both Pharma and Biotech.

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    Healthcare Medians Come Down Across the Board in Q4Across all stages, medians declined. Funding strength in healthcare in Q411 drivenby healthy deal volume.

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    GREEN & CLEAN TECH

    Q4 2011 Venture Capital

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    Green Tech Deals and Dollars Maintain LevelsQ4 sees funding levels exceed $1B in Q411 and in-line with Q311. Relative to Q410,deals were up 17% and funding was up 62%.

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    Texas Green Tech Deals Down but Funding Share Way UpCali remains the overwhelming leader in terms of Green Tech deals and dollars. Texasshows funding strength on back of large Green Tech investment into

    Quarter Highlights

    69 deals | $1,281M

    Top Deals

    Top Cities

    Irving, TX

    2 deals | $206MPalo Alto, CA

    1 deals | $200MSan Jose, CA

    2 deals | $145MSunnyvale, CA

    5 deals | $97M

    Fremont, CA3 deals | $68M

    Tucson, AZ

    1 deals | $50MWestborough, MA

    2 deals | $31MOrem, UT

    1 deals | $30MAshland, OR

    1 deals | $28MSanta Monica, CA

    1 deals | $27M

    Better PlaceStionSoraaeRecyclingCorps

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    Cali and Texas Take 75% of Green Tech DollarsDeal share across states remains consistent. Mega-deals in Cali and Texas havethem eating up most of Green Tech funding in Q4.

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    Early Stage Green Tech Deals Hit 5-Quarter HighAfter Q311s early stage investment beatdown, Q411 sees a resurgence with 40% ofdeals going to Seed and Series A.

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    Renewables Hits Five Quarter Low on Deal ShareRenewables retains top spot, but sees new 5-quarter low in terms of deal share.Energy Efficiency technology has a strong quarter with a number of smaller deals.

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    Green Tech Median Deal Values Generally DeclineOverall and across most stages, median deal values dropped with the exception ofSeries D. The reduction in investment in renewables helped to drop medians across tboard.

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    CALIFORNIA

    Q4 2011 Venture Capital

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    What Smart Investors, Bankers andWealth Managers Use to Get AheadWith CB Insights you can access deep private company info that was once exclusivelyavailable behind prohibitively expensive paywalls.

    Coverage Universe

    Venture Capital 1999 to present Angel Investment

    Private Equity Federal SBIR Grants 3 years State Grant Programs Incubators Over 300 Middle Market Private Companies

    Sector Coverage

    Green/clean tech Internet Mobile & Telecom

    Software Energy & Utilities Computer Hardware & Services Healthcare Industrial Automotive & Transportation Business Products & Services Consumer Products & Services Electronics Environmental Services &

    Equipment Financial Services Food & Beverages Leisure Media Metals & Mining Retail Risk & Security

    CB Insights is accessible for free by visiting http://www.cbinsights.com

    82,000+ Private Company Profiles.

    Company & Investor Updates via Email.

    Add companies and investors ofinterest to your CBI Watchlist and getnotified of changes and updatesautomatically.

    Over 82,000 high value privatecompany profiles across industries andsectors. Medical devices tomobile. Industrial to internet.

    From Angel to Private Equity.

    Angel investment to venture capital toprivate equity to government funding tounder the radar mid-market privatecompanies.

    Management & Board Information

    Find out about the people behind thecompanies including management andboard of directors profiles.

    Analytics & Reporting

    Downloadable reports and analyticswhich allow you to manipulate datawhen and how you want to.

    http://www.cbinsights.com/http://www.cbinsights.com/
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    The Golden State Steady as EverCalifornia stays within its recent historical ranges on both deals and dollars. VersusQ410, deals were down 3% and funding was up 45%.

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    Mega Deals Across Sectors Maintain Funding BalanceOn the deal side, Internet and Healthcare combine for 57% of deal share.

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    Quarter Highlights

    300 deals | $3,836M

    Top Sector# of Deals Internet$ of Funding Internet

    Top Deals

    Top Cities

    San Francisco

    80 deals | $818MPalo Alto

    29 deals | $529M

    San Jose12 deals | $355M

    Redwood City

    12 deals | $313MFremont

    7 deals | $212MSan Diego

    19 deals | $195MSunnyvale

    10 deals | $143MMountain View

    15 deals | $124MSouth San Francisco

    5 deals | $121MMenlo Park

    13 deals | $119M

    DropboxBetter PlaceStionPrysmPortola Pharmaceuticals

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    Healthcare Gains Modestly on Deals & Dollars in CaliNo violent shifts in deal or funding share for Cali during Q411. Quarter continueddemonstration of Calis balanced VC landscape.

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    Early Stage Dealflow Hits Five Quarter HighSeed and Series A grow in number hitting 45% of deals. Series B and beyondcomparable to prior quarter ranges on both deals and funding.

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    MASSACHUSETTS

    Q4 2011 Venture Capital

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    Patriot Nation Hits Five Quarter High on DealsAfter Q311s blah funding total, Q411 registers a 35% sequential increase and 52%year over year increase on funding. Deals were up 12% sequentially and 19% yearover year.

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    Healthcare Wins on Both Deals and Dollars in MassHealthcare activity in Mass stays strong. Internet took back the #2 spot for fundingfrom Energy.

    40

    Quarter Highlights

    93 deals | $959M

    Top Sector# of Deals Healthcare$ of Funding - Healthcare

    Top Deals

    Top CitiesCambridge

    27 deals | $312MBoston

    16 deals | $169MWaltham

    10 deals | $123MNewton

    6 deals | $83MWestborough

    5 deals | $47MWatertown

    4 deals | $44MBedford

    1 deals | $35MCharlestown

    1 deals | $18MSouthborough

    1 deals | $17M

    Woburn2 deals | $16M

    Agios PharmaceuticalsRapid7Cyber-Ark SoftwareZinkSAGE Therapeutics

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    Internet Deals Hit Five-Quarter Low in MassFour out of ten deals and one out of two VC dollars in Mass went to healthcarecompanies. Internet deal share hits a low watermark.

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    Early Stage Hits 5-Quarter High in MassachusettsSeed and Series A combine for 42% of deals tying with levels seen in Q211. LargerSeries A deals primarily in healthcare drove funding share of Series A rounds tohighest level in five quarters.

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    NEW YORK

    Q4 2011 Venture Capital

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    As the Jets Go, So Does New Yorks VC Scene?After a breakout Q311 where NY took the #2 spot for overall VC, NY dipped butremained strong still ahead on both deals and dollars vs. Q410.

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    Get Started for Free with CB InsightsBasic membership on CB Insights is free. Just visit http://www.cbinsights.com. Orconnect with us via any of the following.

    Twitter

    Follow us @cbinsights

    Newsletter

    Click here to receive our weeklydealflow newsletter.

    Email

    [email protected]

    Telephone

    212-292-3148

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    Internet Still Rules, but Mobile and Healthcare Show LifeInternet continues to command the lions share of deals and dollars, but Mobile dealsregister volume and Healthcare consumes serious dollars in Q4.

    46

    Quarter Highlights

    73 deals | $568M

    Top Sector# of Deals Internet$ of Funding - Internet

    Top Deals

    Top Cities

    New York61 deals | $491M

    Buffalo2 deals | $37M

    Ithaca

    3 deals | $28MBrooklyn

    5 deals | $7MHighland

    1 deals | $4M

    Fab.comImagen BiotechOutbrainKnewton

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    Internet Share Shrinks in Terms of Both Deals and DollarsMobile deals see a jump in Q4, reclaiming share of deal volume experienced in Q2.Healthcare experiences 5-quarter high in terms of dollar share.

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    NY Early Stage Experiences Considerable Jump in Q4Following two relative weak quarters, early stage reclaims share in NY withSeed/Series A commanding 60% of deal volume and nearly 40% of investment in Q4.

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    WASHINGTON

    Q4 2011 Venture Capital

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    In Q4, Washington Fails to Build on Recent MomentumVenture deal volume in Washington was down for a third straight quarter, whileinvestment dollars fall substantially after showing some pep in Q3.

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    Internet and Healthcare Continue to Dominate in WashingtonInternet and Healthcare split venture investment dollars fairly evenly, while Mobileconvincingly occupied the third spot.

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    Quarter Highlights

    24 deals | $146M

    Top Sector# of Deals Internet$ of Funding - Internet

    Top Deals

    Top Cities

    Seattle

    15 deals | $92MBellevue

    3 deals | $32M

    Redmond2 deals | $8M

    Bothell

    1 deals | $8MIssaquah

    1 deals | $3MKirkland

    1 deals | $2M

    NanoString TechnologiesadSageRedFinZaarlyDreamBox

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    Healthcare Grows Share for Third Straight QuarterHealthcare continues its tear, as both deal volume and investment dollars grow sharefor the third straight quarter. Could it unseat Internet for top spot in the near future?

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    Early Stage Investing Roars Back in WashingtonSeed maintains its share of deals while Series A quadruples its share of deal volumeversus Q3. Early stage commands nearly 60% of overall deal volume.

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    TEXAS

    Q4 2011 Venture Capital

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    Dollars Up, Deals Down in the Lone Star StateTexas experiences a substantial dip in deal volume in Q4, but investment dollars popon the backs of large deals.

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    Energy Takes a Back Seat; Mobile Owns 50%+ of DollarsTexas maintains sector diversity in Q4 in terms of deal volume, with Energy taking adistant fifth seat. Mobile & Telecommunications swallows over half of dollars invested.

    56

    Quarter Highlights

    24 deals | $476M

    Top Sector# of Deals Internet$ of Funding Energy & Util

    Top Deals

    Top CitiesAustin

    13 deals | $208MIrving

    2 deals | $206MAllen

    1 deals | $30M

    Lewisville1 deals | $11M

    Dallas

    3 deals | $11MSan Antonio

    1 deals | $4MHouston

    2 deals | $4MRichardson

    1 deals | $2M

    WhaleShark MediaeRecyclingCorpsXtera CommunicationsInova LabsMedMark Services

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    Energy Investment Dollars Disappear in Q4Only a quarter after owning more than one-third of venture dollars invested in Texas,Energy falls off the map. Mobile explodes; Internet also grows share.

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    Early Stage Investment Regains Momentum in TexasSeed VC deal volume comes back down to earth, but Series A explodes as early stagecommands 43% of overall deal volume.

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    Definitions Ensuring Data IntegrityWhats Included in our Quarterly Venture Capital Numbers? What is not?

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    Given the importance of venture capital in spurring innovation and entrepreneurship, measuring venture capital activityaccurately is important. We encourage you to review the methodology and definitions employed by us to betterunderstand the numbers presented in this report. If you have any questions about our definitions or methodologicalprinciples, we encourage you to reach out to us directly.

    Equity financings into emerging companies.Funding must come from venture capital f irms includingcorporate venture groups.

    Fundings of only private companies. Publiccompanies of any kind on any exchange (including PinkSheets) are excluded from our numbers even if theyreceived investment by a venture firm(s)

    Companies must be headquartered in the USA. Ourgeographic data is based on the city and state where thecompany receiving investment is headquartered. If acompany has a satellite office/presence in multiple citiesor was founded in a particular city but has moved its HQ,our results reflect only this HQ address.

    Only include the investment made in the quarter fortranched investments. If a company does a secondclosing of its Series B round for $5M and previously hadclosed $2M in a prior quarter, only the $5M is reflectedin our results.

    Round #s reflect what has closed not what is

    intended. If a company indicates the closing of $5M outof a desired raise of $15M, our numbers reflect only theamount which has closed.

    Only verifiable fundings are included. Fundings areverified via (1) various federal & state regulatory filings(2) direct confirmation with firm or investor or (3) pressrelease.

    Funding close date matters. Fundings are providedbased on funding close date and not on announcementdate.

    Angel investment. These are not included innumbers unless an investment round included Angelsinvesting alongside a venture capital firm or corporateventure group.

    No contingent funding. If a company receives acommitment for $20M subject to hitting certainmilestones but first gets $8M, only the $8M is includedin our data.

    No business development/R&D arrangementswhether transferable into equity now, later ornever. If a company signs a $300M R&D partnershipwith a larger corporation, this is not equity financingnor is it from venture capital firms. As a result, it is notincluded.

    Buyouts, Consolidations and Recapitalizations.All three of these of transaction types are commonlyemployed by private equity firms and are tracked byCB Insights. However, they are excluded for thepurposes of this report. Private equity investments into

    companies which may have received venture capitalinvestment prior are also not included.

    Private placements. These investments also knownas PIPEs (Private Investment in Public Equities) evenif made by a venture capital firm(s) are not included.

    Debt/loans of any kind. Venture debt or any kind ofdebt/loan issued to emerging, startup companies evenif included as an additional part of an equity financingis not included. If a company receives $3M with $2Mfrom venture investors and $1M in debt, only the $2Mis included in these statistics.

    Government funding. Grants, loans, equityfinancings by the federal government, state agencies

    or public-private partnerships to emerging, startupcompanies are not included. Strictly venture orcorporate venture outfits.

    Incubator investments. Investments of money asequity or debt and/or services by incubators are notincluded.

    Strategic corporate investments. Corporationsmaking strategic investments in companies but not aspart of a specific organized venture group are notincluded.

    What is included? What is excluded?

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