V43 DNA-Ad26-ALVAC StudyELISpot

SFC/

Mill

ion

PBM

C

CD4 T Cell Response(sum IFN-g, IL-2, TNF; bars at median)

% C

D4

T Ce

lls

CD8 T Cell Response(sum IFN-g, IL-2, TNF; bars at median)

% C

D8

T Ce

lls

CD4 T Cell QualityWeek 27

CD8 T Cell QualityWeek 27

ICS not performed on these samples due to low cell numbers

• Group 1– R218 wk 27 CG7V Env– R222 wk2pp 766 Gag-pro, CG7V Env– R222 wk 27 CG7V Env– R255 wk0 CG7V Env– R255 wk2pp 766 Gag-pro, CG7V Env– R255 wk27 CG7V Env– R257 wk 2pp 766 Gag-pro, CG7V Env– R261 wk 27 CG7V Env– R273 wk 0 CG7V Env– R273 wk 27 766 Gag-pro, CG7V Env– R278 wk 27 766 Gag-pro, CG7V-Env

• Group 2– R220 wk 27 CG7V Env– R224 wk 27 CG7V Env– R227 wk 27 766 Gag-pro, CG7V Env– R230 wk 0 766 Gag-pro, CG7V Env– R230 wk 27 CG7V Env– R259 wk 0 766 Gag-pro, CG7V Env– R259 wk 2pp 766 Gag-pro, CG7V Env– R259 wk 27 CG7V Env– R265 wk 0 CG7V Env– R409 wk27 766 Gag-pro, CG7V Env

• Group 3– R225 wk 27 CG7V Env– R234 wk 27 CG7V Env– R256 wk27 CG7V Env– R260 wk27 766 Gag-pro,

CG7V Env– R264 wk 27 CG7V Env– R266 wk 27 CG7V Env– R272 wk 27 766 Gag-pro,

CG7V Env– R276 wk 27 766 Gag-pro,

CG7V Env– R408 wk 27 766 Gag-pro,

CG7V Env