v w } l< ] u > µ / u p r p µ ] µ p Ç o ] } z ] p ] À Ç u · 9lvxdo udqjhri wkholjkw 9,6...
TRANSCRIPT
![Page 1: v W } l< ] u > µ / u P r P µ ] µ P Ç o ] } Z ] P ] À Ç u · 9lvxdo udqjhri wkholjkw 9,6 vxshuilfldo 7lvvxh+hprjorelq,qgh[ ±7+, 9,6 udqjh vxshuilfldo 1hdu,qiud5hg 1,5](https://reader036.vdocuments.site/reader036/viewer/2022071006/5fc38d5be27c6128801893ad/html5/thumbnails/1.jpg)
Jin Pok Kim LectureImage-guided surgery applied to the
digestive systemInes Gockel
Department of Visceral, Transplant, Thoracic and Vascular Surgery
University Hospital of Leipzig
13th International Gastric Cancer Congress (IGCC) 2019
May 9th 2019, Prague
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The evolution of imaging-guided surgery
© Universitätsklinikum Leipzig AöR (09.05.2019): Key Note Lecture, IGCC Prague, Ines Gockel
MRI
PET/CT
HSI
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Development of clinical optical imaging
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
de Boer E, et al. BJS 2015
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Principles of intraoperative optical imaging
Optical imaging related to the electromagnetic spectrum
NIR is not visible to the human eye and can be detected bysensitive charge-coupled device cameras only
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Hallmarks of cancer and their targets for opticalimaging
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Biomarker selection tool and TArget Selection Criteria(TASC) and scoring system
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Mechanism of action of fluorescent probes
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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First human imaging of ovarian cancer, targetingfolate receptor
Systemic injection of folate-fluorescein isothiocyanate
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Intraoperative photoimmunodetection and -therapy
de Boer E, et al. BJS 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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ICG = IndoCyanine Green
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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ICG properties
Protein binding – to plasma proteins quickly, ß-Apolipoprotein B (95%)
Metabolism – ICG is not metabolized
Elimination – biphasic with an initial half life of 3-4 min and a second t ½ of about 60-80 min; elimination via bile(unconjugated)
Concentration maximum – in bile after ½ to 2 hours
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Augmented Reality (AR)
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Augmented virtuality-based navigation system
3D patient model using CT scan data only or 3D model associatedto the instrument positions, which are updated in real time due to a tracking system
Azagury DE, et al. Curr Probl Surg 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Data superimposition
tablet, PC: illustration of patient model directly projected on patientskin or organ surface
overlay of preoperative patient 3D model using landmarks, whichare automatically tracked in the video using image processing
Azagury DE, et al. Curr Probl Surg 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Virtual Reality 3D modeling
examples of human body modeling using surface renderingtechnique & display the 3D model in the OR
Mascagni P, et al. J Surg Oncol 2018
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Augmented Reality overlay in laparoscopic surgery
liver tumor (green), surrounding vessels (dark and light blue) and the resection plane (pink)
Azagury DE, et al. Curr Probl Surg 2015
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Modalities for display of Augmented Reality
projector-based overlay of the VR model on the real patient –transparency visualization / screen based visualization of thevirtual model demonstrating the position of the liver tumor (green) by transparency
Mascagni P, et al. J Surg Oncol 2018
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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FLEER – Fluorescence-based enhanced reality
to evaluate bowel perfusion; the VR-perfusion software calculates theslope of the fluorescence time-to peak, which is converted to a virtualperfusion cartogram
white light image is merged with the perfusion cartography obtainingan AR-view of the bowel perfusion
Mascagni P, et al. J Surg Oncol 2018
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Hyperspectral Imaging (HSI)
Developed in the 1960‘s from the
Current applications:
-Aerospatial sensing
-Recycling
-Industrial (material‘s quality and quantity)
-Vegetation
-Fruit contamination and quality control
-Archeology
-Crime scene detection
-Food sorting / agriculture
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI technology
non-invasive tissue analysis
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Basics of technology I
Electromagnetic waves – absorption spectroscopy
Human eye / usual cameras multispectral – 3 channels: Red, Green, Blue (RGB)
Multispectral camera with 4-8 channels
Hyperspectral, optical measurement with 100 colour channels in the range of 500-1000 nm
Non-invasive, contactless, fast and reliable
Camera works like an imaging tissue oxymeter
UV light Visible light Near InfraRed (NIR) light
range of the TIVITA® Tissue
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Basis of technology II
schematic representation of the HSI camera system
Measurement conditions:
Surroundings: as little external light as possible
no dressings or clothes
as little liquids as possible
Distance: 50 cm
Time of measurement: 6,4 s
Time of processing: 18 s
Result: 30 s
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Hyperspectral imaging aquisition methods
Shapey J, et al. J Biophotonics 2019
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Camera technology
Camera-technology for recording and visual representation of chemical tissue information
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Basis of technology IIIHyperspectral cube
Shapey J, et al. J Biophotonics 2019
-> spectral signatures can be generated for specific tissues© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Recording of spectral measurement data
Known spectra
Knowledge of scattering and absorption properties
Presence, quantity & state of the components
green: TIVITA®; orange: pulse oxymeter
relevant componentswavelength (nm)
absorption spectrahemoglobin
ab
so
rpti
on
co
eff
icie
nt
(cm
-1M
-1)
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Current parameters of spectral measurement
Oxygenation of Hemoglobin – StO2:
Visual range of the light (VIS), superficial
Tissue Hemoglobin Index – THI:
VIS range, superficial
Near InfraRed (NIR)-Perfusion:
NIR range, oxygenation in
deeper layers
Tissue Water Index – TWI:
NIR range, oxygenation in
deeper layers
absorption spectrahemoglobin
relevant components
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Recording of spectral measurement data I
RGB image (color image)
Color image calculated from the recorded spectra similar to a normal photo but with objective comparable color
HI / OHI image
Relative volume fraction & distribution of hemoglobin in the viewed image areaColor scale:Red (high hemoglobin content) toBlue (low hemoglobin content)
Oxygenation image
Oxygen saturation of the hemoglobin distributed in the tissueColor scale:Red (high oxygenation) toBlue (low oxygenation)
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Recording of spectral measurement data II
NIR Perfusion image
Describes the oxygenation of deeperlayers of the tissueColor scale:Red (high perfusion) toBlue (low perfusion)
TWI imageDistribution of the tissue water in the viewed image areaColor scale:Red (high water content) toBlue (low water content))
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Recordings of spectral measurement data III
Occlusion-study for validation
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Clinical applications I
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Clinical applications II
Wound-imaging
visual: clear necroses (black),undefined areas
HSI: necrotic areas that are not visuallyrecognizable, white necroses
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Clinical applications III
Wound-imaging
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI in gastrointestinal anastomoses
anastomotic evaluations: perfusion, oxygenation, water content
Jansen-Winkeln B... Gockel I, Chirurg 2018
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-application in GI-anastomoses I
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-application in GI-anastomoses II
with AL without AL
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Current limitations: Camera size in minimally invasiveprocedures
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Measurements via mini-laparotomy in MIS
Mini-laparotomy: extracorporeal phase
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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‚Key Point‘: Perfusion of the proximal gastric tubeduring esophagectomy
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Intrathoracic anastomosis
Nguyen NT, et al. Ann Surg 2008
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-measurement of the gastric tube
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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ROI anastomosis
Oxygenation (StO2)
25 mm
mean ROI in n=30 patients
StO2ROI = 62%
Analysis of HSI-parameters in the area of the lateranastomosis
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Discrimination of areas with high and low perfusion
high perfusion
low perfusion
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-evaluation of the gastric tube
RGB-image Oxygenation (StO2) NIR-Perfusion-Index
Tissue Water-Index Tissue Hemoglobin-Index
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-evaluation of the gastric tube
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Kork, Karl-Heinz
before intrathoracic anastomosis
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Kork, Karl-Heinz
after intrathoracic anastomosis
47© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Gastric tube: HSI-results I
Köhler H,...Gockel I, et al. Surg Endosc 2019
Tissue oxygenation of thegastric tube was significantlyhigher in patients withischemic conditioning(P=0.03)
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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OFS = Optical Fibre Spectroscopy (SaO2)
Blood Volume Fraction (BVF)
Pham TA, et al. Ann Thorac Surg 2011
measurements:-baseline-after devascularization of the stomach-after gastric tube formation-after transposition of the gastric tube
-> correlation of SaO2- / BVF-findings with clinical results
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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(AV-) SaO2- and BVF-changes in patients with and without ischemic conditioning
ischemicconditioning
no yes P-value no yes P-value
short gastricvessles
88.6+ 19.7
92.9+ 11.2
0.69 1.10+ 0.61
1.10+ 0.28
0.99
left gastricartery
74.4+ 26.3
77.4+ 31.0
0.86 1.25+ 0.59
0.96+ 0.34
0.22
gastric tubeformation
67.8+ 37.7
87.8+ 50.6
0.57 1.33+ 0.66
0.99+ 0.73
0.50
gastric tubetranspo-sition
80.7+ 28.6
100.0+ 82.4
0.25 1.56+ 0.62
1.41+ 0.53
0.63
% SaO2 (Mean + SD)* % BVF (Mean + SD)*
*relation in % to the basic value
Pham TA, et al. Ann Thorac Surg 2011
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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LYSIS-project = laparoscopic hyperspectral system
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Determination of the transection margin in colorectalresection with HSI
Jansen-Winkeln B, ...Gockel I, Int J Colorect Dis 2019
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Proximal Resection Border (PRB)
intraoperative visualization of the surgeon is not objective
too much resection: perfusion , but bowel probably tooshort!
too short resection: perfusion
optimum transection line!? PRB
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Proximal Resektion Border (PRB): Where would you transect the descending colon?
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Proximal Resektion Border (PRB): Where would you transect the descending colon?
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Proximal Resektion Border (PRB): Where would you transect the descending colon?
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Comparison with objective HSI-measurement
difference of 2.5 cm
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Comparison of subjective vs. objective determinationof the transection line (descending colon) I
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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before and after devascularization
Jansen-Winkeln B,... Gockel I, Int J Colorect Dis 2019
Comparison of subjective vs. objective determinationof the transection line (descending colon) II
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Time course (min after devascularization)
Jansen-Winkeln B,... Gockel I, Int J Colorect Dis 2019
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Tissue characterization with HSI
Differentiation of thyroid and parathyroid in vivo
absorption spectraHSI-data
classification
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Tissue-classification with HSI
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Current miniature camera variations
integrated camera for OR-microscopy
variants for minimally invasive surgery and endoscopy
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Perspectives
Combined application of molecular targets of opticalimaging, ICG & HSI
Optimization of surgical results (anastomotic healing)
Tissue and tumor classifications
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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Thank you
for your attention!
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel
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HSI-workshop at the University Hospital of Leipzig
17th May, 2019
Save the Date
in association with:The German
Society of Generaland Visceral Surgery
(DGAV)
© Universitätsklinikum Leipzig AöR (09.05.2019): Jin Pok Kim Lecture, IGCC 2019 Prague, Ines Gockel