v d latent dorsalizing factors the point of fertilization orients the d/v axis of the frog

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Page 1: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog
Page 2: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

V

D

Latent Dorsalizing Factors

The Point of Fertilization Orients the D/V Axis of the Frog

Page 3: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

ß-Catenin Acts as a Morphogen to Pattern the D/V Axis

Page 4: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Gastrulation: From Embryo to Tadpole

Page 5: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog
Page 6: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Cleavage: From Fertilized Egg to Blastula

Page 7: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Gastrulation of A Frog Embryo

Page 8: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Evolutionary Conservation of Hox Expression Patterns

Page 9: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Evolutionary Conservation of Hox Gene Function

Page 10: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Evolutionary Conservation of Hox Gene Function

Wild-Type Antenna

Antenna Transformed by Mouse Hox Gene

Wild-Type Leg

Claw Claw

Page 11: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Neural Induction by the Spemann Organizer

Page 12: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

The Mangold Spemann Experiment

Page 13: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Chordin Versus BMP Expression in Frog Embryo

Page 14: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Allow Cells toDifferentiate

Animal Caps

Reaggregate Cells

Incubate

Dissociate Cells

Page 15: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Allow Cells toDifferentiate

Animal Caps

Reaggregate Cells

Incubate

Dissociate Cells

+ BMP4+ BMP4+ Chordin

Allow Cells toDifferentiate

Animal Caps

Reaggregate Cells

Incubate

Dissociate Cells

+ BMP4

Page 16: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Allow Cells toDifferentiate

Animal Caps

Reaggregate Cells

Incubate

Dissociate Cells

+ BMP4+ BMP4+ Chordin

Allow Cells toDifferentiate

Animal Caps

Reaggregate Cells

Dissociate Cells

Incubate + BMP4+ BMP4+ Chordin

Page 17: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Evolutionary Conservation of BMP Signaling

Page 18: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Evolutionary Conservation of BMP Signaling

Page 19: V D Latent Dorsalizing Factors The Point of Fertilization Orients the D/V Axis of the Frog

Inverted-brateHypothesis

Evolutionary Conservation of Neural Induction