usman mast cell and microglial activation -...
TRANSCRIPT
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
Page # 1
Dr.AnjuUsmanSingh,MD,FAAFP,ABIHM,Hom-C,FMAPS
Mast Cell and Microglial Activation
Implications for ASD
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Disclaimer
• Informationisforeducationalpurposesonly• Nottobetakenasspecificmedicaladvice• Allmedicaldecisionsregardinghealthissuesshouldbediscussedwithyourhealthcareprovider
• Clinicaltrialshavenotbeendoneonsometreatmentapproachesdiscussed
• Ideasandconceptsdiscussedareconsideredalternativetheoriesandnotstandardofcareyet
• Dr.UsmanSinghisMedicalDirectorofTrueHealthMedicalCenterandPureCompoundingPharmacy
• TrueHealthNaturals,Familyowned.
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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HOPEism
It is difficult to say what is impossible, for the dream of yesterday is the hope of today and the reality of tomorrow. Robert H. Goddard
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Neuroinflammation
• Neuroinflammationiswidelyregardedaschronic.• Acuteinflammationusuallyfollowsinjurytothecentralnervoussystemimmediately,andischaracterizedbyinflammatorymolecules,endothelialcellactivation,plateletdeposition,andtissueedema.
• Chronicinflammationisthesustainedactivationofglialcells,mastcellsandrecruitmentofotherimmunecellsintothebrain.
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Causes of Neuroinflammation
• Toxic metabolites • Autoimmunity • Allergens • Aging • Microbes/Infections • Viruses • Traumatic brain injury • Spinal cord injury • Air pollution • Passive smoke • Mycotoxins • Stress
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The Unresolved Inflammatory Response aka Chronic Inflammation
• TheInnateImmuneresponseisactivated• MastCellsdegranulate• Microglialactivated• Glutamateisreleased• ExcessExcitationensues• Leadingto
• Dysautonomia• Mitochondrialdysfunction• Proteinaggregation(hyper-coaguablestate)• Oxidativestress• Abnormalneuronalconnectivity(choking)
Nicolas G. Bazan, ... Ludmila Belayev, in Basic Neurochemistry 2012
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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n engl j med 373;2
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PossibleSymptomsofMastCellActivation
• AtopicorAllergicSymptoms• Hives(urticaria),Feetingrashes,Flushing
• Angioedema• Itching• NasalCongestion• ShortnessofBreath• ChestTightness• Tachycardia• HighorLowBloodPressure
• Fatigue• MusculoskeletalPain• Nausea/Vomiting• Migraine• Difficultyconcentrating• Memoryloss• Anxiety
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Various triggers cause Mast Cells to degranulate And release a variety of inflammatory cells Mast Cells cause Microglial Activation
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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http://www.frontiersin.org/files/Articles/112233/
Microglia release proinflammatory cells, that cause Glutamate release from neurons, Glutamate binds to the NMDA receptor, Allowing Calcium to flow into cells rapidly Excess Calcium excites the cells and causes damage to neurons
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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The principle excitatory receptor, the N-Methyl-D-Aspartate (NMDA) receptor, and its associated calcium (Ca2+) permeable ion channel are activated by glutamate.
©TrueHealthMedicalCenter5/15/19 Copyright by Dr. TC Theoharides
Courtesy Dr. Theoharides
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Histamine,
IL-6, NGF,
NT
CRH, NGF, NT, SP
IL-6, TNF Microglia
Neuron
Mast cell
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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“IntegrativeApproachtoMastCell/MicroglialActivation”
• DietaryInterventions• Anti-inflammatoryDiet:CF/GF/grain-free,lowglutamate,avoidexcitotoxins• Considerlowlectindiet-nightshadefreeandlegumefree• FAILSAFEDiet• Antioxidant,phytonutrient,highcarotenoiddiet
• Treatpotentialunderlyingcause!!!!!!-Toxin,Infection,Allergen*AddressMastCellActivation/MicroglialActivation*AddressGlutamateExcitation(Calciumdriven)*AddressDysautonomia/VagalNerveDysfunction• Improvecirculationandhyper-coagulation/*HBOT• CellMembraneSupport-Omega3’sEPA/DHA-highdose,PC,PS*OtherAnti-inflammatoryagents
• Spices• Foods• Herbs• EssentialOils
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ConsiderMastCellActivationwiththeseConditions
• ASD• AcuteRegressions
• SeasonalRegressions• AllergicDisorders• ReactionstoFood,Chemicals,Temperature,Stress
• Asthma• Eczema(rashes)• MultipleChemicalSensitivities• EhlersDanlosSyndrome
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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LaboratoryWorkupImmune:InfectiousTriggers
• Bacterial-Lyme,Bartonella,Babesia,Mycoplasma/Chlamydiapneumoniae,ASOTiter,AntiDNAseBAb
• Parasitic-ToxoplasmosisAb• Fungal• ViralTiters-EBV,CMV,HHV6• VaccineTiters-MMR,VZ• OrganicAcidTest(OATS)Clostridia• StoolTest-bacteria,yeast,parasites
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LaboratoryWorkupImmune:InflammatoryMarkers
• CBC• CRP,SedimentationRate,PlateletCount• Fecalcalprotectin,lactoferrin,lysozyme• OxidativeStressMarkers
• 8OHDeoxyguanosine,LipidPeroxides,Malonodialdehyde• TotalImmunoglobulinProfile
• (totalIgE,IgM,IgA,IgAandIgGsubclasses)• TLymphocytePanel-CD4/CD8• Naturalkillercell,CD57
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Work - Up Inflammation
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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LaboratoryWorkupImmune:AutoantibodiesandAllergy
• Autoantibodytests(e.g.myelinbasicproteinantibodies,antidopamineAb,antigangliosideAb)
• OtherAutoimmuneAb-NMDA,GAD65Ab• ANA• CeliacPanel• MycotoxinPanel• IgERASTorskintestingforinhalants,food,mold
• IgGELISAtestingforfoodsensitivities
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NaturalAgentstoDecreaseMicroglialActivation
• Resveratol-neuroprotective• Pycnogenol-antioxidant• Gastrodiaelata-braininjuryneuroprotective• Piperakadsura(Japanesepepper)-PGE2inhibitor• Ganodermalucidum(ReishiMushroom)-immunemodulatory
• Epimediumbrevicornum(HornyGoatWeed)-improvesbloodflow
• Fisetin-antiaging• PQQ(pyrroloquinolinequinone)-PGE2andCOX-2inhibitor
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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NaturalAgentstoDecreaseMicroglialActivation
• Luteolin-mastcellstabilizer• PEA(palmitylethanolamide)• Resveratol-neuroprotective• Pycnogenol-antioxidant• Gastrodiaelata-braininjuryneuroprotective• Piperakadsura(Japanesepepper)-PGE2inhibitor• Ganodermalucidum(ReishiMushroom)-immunemodulatory• Epimediumbrevicornum(HornyGoatWeed)-improvesbloodflow• Stephaniatetranda-Cachannelblocker• Fisetin-antiaging• Benfotiamine/Biotin• Vinpocetine-PDEinhibitor,Caregulation• PQQ(pyrroloquinolinequinone)-PGE2andCOX-2inhibitor
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Natural and Pharmaceutical Agents for Mast Cell Activation
• StingingNettles• Quercetin• Luteolin-mastcellstabilizer,antiIL-6• PEA(palmitylethanolamide)• BlackCuminSeedOil• NRF2signaler/Antioxidants:sulfuraphane,DIM,EGCG• H1blockers:diphenhydramine,chlorpheniramine,cyproheptadine,hydroxyzine
• H2blockers:ranitidine,cimetidine,famotidine• MastCellStabilizers:ketotifen,rupatadine,cromolynsodium
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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AvoidDietaryExcitotoxins
• Caffeine• MSG• NutraSweet• Red/yellowfooddyes• Nitrites• Sulfites• Glutamates• Propionates• Benzoates• Limitintakeofphenolics(apples,grapes,bananas,strawberries,…).
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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LimitDietaryGlutamate
• Glutamate• MonosodiumGlutamate(MSG)
• HydrolyzedProtein• ModifiedFoodStarch• NaturalFlavors• Peas,Mushrooms,Tomatoes
• ParmesanCheese• ExcessProtein
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GlutamateModulators
• Magnesium• P5P• Lithium• Leucine• Isoleucine • Lysine• L-Theanine• Taurine• Hypotaurine• Oxaloacetate• GABA• PQQ• Memantine/NamendaRx• Dextromethorphan/NudextaRx
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Glutamate Modulators
CalciumModulation- VitaminD3- VitaminK2- Vinpocetine - Stephaniatetranda
Herbs- Gingkobiloba- Silymarin- Rosemary-LemonBalm- Chamomile- SkullCap- Bacopa- Pycnogenol
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Address Dysautonomia
Down-regulateSympathetic• AdaptogenicHerbs-Ginseng,Ashwaganda,Bacopa,Tulsi• BetaBlockers-Propranolol• Alpha2adenoreceptoragonists-Clonidine,Guafacine• NMDAreceptorantagonists-Memantine,Dextromethorphan• Upregulateinhibitoryneurotransmitters-GABA,L-theanine,Taurine,Glycine
• Benfotiamine
Up-regulateParasympathetic• Acetylcholine(phosphatidylcholine,phosphatidylserine)• AcetylcholinesteraseInhibitors(galantamine,huperizineA,piracetam)
• VagusNerveStimulation(TENSunit)
AddressGutIssues-especiallySIBO• NemecheckProtocol
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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The Polyvagal Theory: Phylogenetic Contributions to Social Behavior
Stephen W. Porges
• Vagal regulation of heart rate and heart rate variability
• Vagal brake = modulates the visceral state
• enables the individual to rapidly engage and disengage with objects and other individuals and to promote self-soothing behaviors and calm behavioral states
• The vagal brake is obviously compromised in autism.
New conceptualization of the role of Vagus
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Polyvagal Theory Cont’d
• TheVagusisinvolvedintheregulationoftheHPAaxis.
• VagalafferentsexhibitaninhibitoryinfluenceonHPAaxisandreducecortisolsecretion.
• TheafferentVagusmediatesbehavioraldepression.
• VagusnerveandAcetylcholinehelptomediategastrointestinalinflammation.
• Lossofvagaltonetotheheartcausesincreasedsympathetictoneandreleaseofcortisol.Highcortisolcausessuppressedimmunefunction.
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
plant compounds that have a normalizing impact on the HPA axis under times of stress, help with blood sugar regulation, anxiety, immune modulation
• PanaxGinseng• SiberianGinseng• HolyBasil• Licorice/Glycyrrhizin• Rhodiolarosea• Ashwaganda• Bacopa• GotuKola• Moringaoleifera• Schisandra
Adaptogens
http://naturehacks.com/3-common-mistakes-made-when-taking-herbal-remedies/
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Medicinal Herbs
• Usedtraditionallybyallculturesforhealing• Complexstructures• Numerousqualities• Multiplecomponents• Availableasdriedherb,tinctures,decoction,oils• Canbeeateninfoodsorasteas• Carefulwithdrugandvitamininteractions• Carefulwithphenolandoxalateissues• Irecommendtorotateandpulsewhenusinglongterm• Manydrugstodayareoriginallyderivedfromherbs
Role of Plant Based Therapies in ASD
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Licorice/Glycyrrhizin
• Preventsbreakdownofcortisoltocortisone
• Increaseshalflifeofcortisol• Selectiveestrogenreceptormodulator
• Immune• Antiviral• Isoflavinoid:antimicrobial,antifungal
• Preventulcerformation• Stimulateshealingofmucosa
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Holy Basil (Tulsi)
• Adaptogenicherb• Antianxiety• Bloodsugarregulation• Antibacterial,antiviral• Anti-inflammatory• Helpswithheadaches• Reducesfever• GoodsourceofVitaminK• Activecompounds:eugenol,rosmarinicacid,apigenin,myretenal,luteolin,β-sitosterol,andcarnosicacid
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Ashwaganda Withania somnifera
• Anti-inflammatory• Antitumor• Antistress
• Modulatescortisol
• Exerciseintolerance• Fatigue• Antioxidant
• Brainlipidperoxidation• Immunomodulatory
• Mobilizationandactivationofperitonealmacrophages,phagocytosis,andincreasedactivityofthelysosomalenzymes
• Hemopoetic“ScientificBasisfortheTherapeuticUseofWithaniasomnifera(Ashwagandha):AReview”Lakshmi-ChandraMishra,MD(Ayur).AltMedReview2000
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Buhner Herbs (anti-inflammatory)
• Polygonumcuspidatum(JapaneseKnotweed)–protectstheendotheliallining
• Scutellariabaicalensis(ChineseSkullcap)-inhibitscytokinecascade
• Salviamiltiorrhiza(RedSage/Danshen)-inhibitscytokinecascade
• ImmuneModulators• Cordyceps• Reishi• Rhodiola• Scutellariabaicalensis(ChineseSkullcap)• Unicariatomentosa(Cat’sclaw)• Eleutherococcussenticosus(SiberianGinseng)• Withaniasomnifera(Ashwaganda)
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Effect of Propranolol on Verbal
Problem Solving in Autism Spectrum
Neurocase:TheNeuralBasisofCognition2008,Beversdorf
• DrugsdecreasingnoradrenergicactivityarebeneficialinASD.
• Beneficialfordifficultnetworkflexibility-dependentproblems.
• Benefitsperformanceforsimpleproblems.• DecreasedflexibilityofaccesstonetworksinASD.• ASDsubjectsbenefitedfrompropranololonsimpleanagrams,whereascontrolsubjectswereimpairedbypropranolol.
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A Prospective, Open-Label Trial of Galantamine in Autistic Disorder
Dr. Rob Nicolson, Beth Craven-Thuss, and Judy Smith. Journal of Child and Adolescent Psychopharmacology.
October 2006, 16(5): 621-629.
• Thirteenchildrenwithautism(meanage,8.8±3.5years)participatedina12-week,open-labeltrialofgalantamine
• Results:Patientsshowedasignificantreductioninparent-ratedirritabilityandsocialwithdrawalontheABC
• SignificantimprovementsinemotionallabilityandinattentionontheConners’ParentRatingScale—Revised
• Clinicianratingsshowedreductionsintheangersubscale• Eightof13participantswereratedasrespondersonthebasisoftheirimprovementscoresontheClinicalGlobalImpressionsscale
• Overall,galantaminewaswell-tolerated,withnosignificantadverseeffectsapartfromheadachesinonepatient
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Phosphadityl Serine
• Lowerscortisol• Increasescellularmetabolism• Antioxidant• Improvesmood• Improvesmotivation• Decreasesanxiety• Improvesmemoryandcognition• Preventshippocampaldamagefromhighcortisol
©TrueHealthMedicalCenter
Phosphatidyl Serine
• Supportsthefunctionofmanyvitalenzymes.• Actsasanantioxidant,andquellsinflammationinthebrain.• InEuropeandJapan,phosphatidylserineissoldasaprescriptiondrugtotreatmemoryandlearningdysfunction.
• Agedratswithcognitivedeficitshavedemonstrateddecreasedphosphatidylserineinthehippocampus.
• Helpswithstressinduceddamageinthebrain.
• UlmannL.Brainandhippocampusfattyacidcompositioninphospholipidclassesofaged-relativecognitivedeficitrats.ProstaglandinsLeukotEssentFattyAcids.2001Mar;64(3):189-95.
• LomnitskiL.DistinctalterationsinphospholipidmetabolisminbrainsofapolipoproteinE-deficientmice.JNeurosciRes.1999Nov15;58(4):586-92.
• SuzukiS.Oraladministrationofsoybeanlecithintransphosphatidylatedphosphatidylserineimprovesmemoryimpairmentinagedrats.JNutr.2001Nov;131(11):2951-6.
• CastilhoJC.Phosphatidylserine:anantidepressiveoracognitiveenhancer?ProgNeuropsychopharmacolBiolPsychiatry.2004Jul;28(4):731-8.
• PepeuG.Nootropicdrugsandbraincholinergicmechanisms.ProgNeuropsychopharmacolBiolPsychiatry.1989;13SupplS77-S88.
• SchreiberS.Anopentrialofplant-sourcederivedphosphatydilserinefortreatmentofage-relatedcognitivedecline.IsrJPsychiatryRelatSci.2000;37(4):302-7.
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Hyperbaric Oxygen Reduces Neuroinflammation
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HBOT Decreases Neuroinflammation in Rat Model of TBI
(2.8 ATA, 2 sessions for 45 min each)
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Hyperbaric treatment for children with autism: a multicenter randomized, double blind, controlled
trial
BMCPediatr.2009RossignolDA,RossignolLW,SmithS,SchneiderC,LogerquistS,UsmanA,NeubranderJ,MadrenEM,HintzG,GrushkinB,MumperEA.
Childrenwithautismwhoreceivedhyperbarictreatmentat1.3atmand24%oxygenfor40hourlysessionshadsignificantimprovementsinoverallfunctioning,receptivelanguage,socialinteraction,eyecontact,andsensory/cognitiveawarenesscomparedtochildrenwhoreceivedslightlypressurizedroomair.PMID:19284641
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Anti-inflammatory Herbs, Spices and Foods
DecreaseIL-6• Allspice• Apple• Basil• Bayleaves• Blackpepper• Caraway• Chilipepper• Cinnamon• Clove• Ginger• Holybasil• Licorice• Nutmeg• Paprika• Sage• Oregano• Rooibostea• Thyme
DecreaseTNF-alpha• Billberry• Caraway• ChiliPepper• Licorice• Nutmeg• Oregano• Sage• Thyme• Bayleaf• Cinnamon• BlackPepper
Increase IL-10
• Allspice• Basil• Cardomom• ChiliPepper• Ginseng• Marjoram• Oregano• Paprika• Pomegranate
Decrease COX-2
• BayLeaf• Nutmeg• BlackPepper• Basil• Thyme• Apple• Clove• Anise
Decrease iNOS
• Licorice• Sage• Fenugreek• Oregano
©TrueHealthMedicalCenter
Common Anti-inflammatory Herbs
Curcumin-Turmeric• COX-2inhibitor,anti-prostaglandin• Similartoibuprofen• Antimicrobial• Breaksdownbiofilms• Preventsbloodclots• Helpsjointpain• NRF2stimulator• Poororalabsorption• InhibitsCOMTandMAOagenes
Boswellia–Indianfrankincense• 5-LOX(lipoxygenaseinhibitor)• TNFalphainhibitor• Antibacterial• Helpswithjointpain• Improvesspatialmemory
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Other Anti-inflammatory Herbs
• Cat’sclaw/Samento(Unicariatomentosa)• NaturalCalciumChannelBlocker• Antiviral,Antibacterial• Immunemodulator• ProtectsDNAfromdamage
• MilkThistle(Silymarin)• IncreasesSODandincreasesglutathioneproduction• Protectsliverandkidney
• Ginger• InhibitsNO,COX-2,andPGE2• Helpswithnausea
www.2bucketscleaning.com/2017/12/5-useful-essential-oils/
Stress and the Autonomic Nervous System
©2012 True Health Medical Center
Anju Usman, M.D. True Health Medical Center.
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Essential Oils
• Usegoesbacktoancientcivilizations2000BC• Usedbyallcultures,traditionallyasperfumes,cosmeticsandformedicinalproperties
• Volatilearomaticcompounds• Changestatequicklyfromliquidtogasatroomtemperature
• Lipophilic,fatsolublecompounds,canpenetratetissueandcells
• Potent,maycauseirritationtoskinandmucosa• Extractedfromfruits,plants,herbs,flowers,stems,leaf,seed,rootorbarkbysteamdistillation
EgyptianMedicinalEssentialOilFormulas
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Using Essential Oils Safely
• Topical-Maybeappliedinsmallquantitieswithacarrieroil• AccupuncturePoints• ReflexologyPoints• Massage• Triggerpoints• Carefulwithcitrusoils,maycausephotosensitivity
• Aromatic-Maybeinhaled,diffusedornebulized• Internal-Someoilscanbeconsumed(teas,water)andusedincooking
• Lessismore• Rotatevariousoils• Avoidprolongeduseofthesameoil• Readlabelsregardinguse
Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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NeuroprotectiveOils
• CholinesteraseInhibitors• Polygonumhydropiper–Marshpepperknotweed• Rumexhastatus-Arrowleafdock• Narcissuspoeticus-Daffodil• Salvialevifolia-sagefamily• Marlierearacemose-BidiLeafTree• Cistusfamily-RockRose
• SustainedAttention• Eucalyptusglobulus• Lavandulaaugustifolia• Rosemarinusofficinalis• Methapeperita• Jasmine
©TrueHealthMedicalCenter
AntioxidantOils
• Lavender–increaseGSH• Thyme• Coriander-increaseGSHinhippocampus• Clove• Eucalyptus• Cinnamon• Juniper• Basil–anticonvulsant,helpswithsleep• Chamomile• Cumin• Coriander• Thyme• Oregano• CommonYarrow• Salviamulticaulis
Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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Stress and the Autonomic Nervous System
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Anju Usman, M.D. True Health Medical Center.
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©TrueHealthMedicalCenter
Antimicrobial,AntioxidantandAnti-InflammatoryActivityofEssentialOils
• EucalyptusOil• LemongrassOil• ThymeOil• LinderniaOil• GeraniumOil• TeaTreeOil
• Antimicrobial• E.Coli-All• Staphylococcus-All• GramNegbacteria-notgeranium• Candida-lemongrass,thyme,lindernia• Pseudomonas-none
• DecreasedTNF-alpha–notgeranium• DecreasedLOX-5• DecreasedIL-1Beta• DecreasedIL-8• DecreasedNO• Lemongrassmostpotentantimicrobial• Thymemostpotentantioxidant
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Anju Usman, M.D. True Health Medical Center.
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Bitters/HOPS in Beer Have an Anti-inflammatory Effect in Alzheimer’s Mice
©TrueHealthMedicalCenter
Consider incorporating more herbs and oils in your daily routine
drinking, eating, sleeping, bathing…
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