PowerPoint Presentation

Using RealTimefMRI Based Neurofeedback To Probe Default Network Regulation

R. Cameron Craddock, PhDDirector of Imaging, Child Mind InstituteResearch Scientist, Nathan Kline Institute

February 25, 2016

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Default Network

Task based deactivationBuckner et al. Ann. N.Y. Acad. Sci. 1124: 1-38 (2008).

Default Network Connectivity

Greicius et. al. 2007 Biol. Psychiatry

DN Dysregulation

Sheline et. al. 2009 PNAS

ICN Competition

Fox MD PNAS 2005

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RT Neurofeedback of DMNTest hypothesis of DMN dysregulation in depression, ADHD, aging, etc

Exp. Design

Class Training Labels

Training run

Time-LabeledScans

Image Recon and SVM Classification

Image Data

Data AcquisitionStimulus Presentation

StimulusConventional FMRI

Test Data Classifier OutputTesting Run

Real-Time Tracking RSNsLaConte, et al. (2007) Hum Brain Mapp. 28: 1033-1044Stephen LaConte August 19, 2009

Stimulus seen by volunteerUpdated fMRI resultsMotion tracking and correctionIntensity (brightness) of a single voxel, changing during stimulus conditionsController interface for display parameters

Decoding DN Activity

DMN Modulation Task

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Modulating the DMN

Results

Accuracy was measured from Pearsons correlation between task paradigm and DMN activity extracted after post-processing.

Behavioral Correlates

Measures that were significantly associated with DN regulation include (p 10,000 datasets6,422 individuals4 90 years old539 ASD383 ADHD72 Schizophrenia29 Cocaine Dependent6 Epilepsy

http://fcon_1000.projects.nitrc.org/

Sharing preprocessed dataMake data available to a wider audience of researchersEvaluate reproducibility of analysis results

http://preprocessed-connectomes-project.github.io/

Software to enable a new scale of data analysisVery large datasetsNeed to harness high-performance computing to expedite processingRS fMRI preprocessing is a moving targetMany new methods are proposed all the timeNeed to compare outputs from different processing strategiesMany different toolsets have different strengthsNeed to be able to combine tools from different packages

http://fcp-indi.github.io/

Principles of Open NeuroscienceData, tools and ideas should be openly shared-The Neuro Bureau Manifesto

http://www.neurobureau.org

AcknowledgmentsChild Mind InstituteMichael Milham, MD, PhDZarrar Shehzad

Nathan Kline InstituteAmalia McDonaldStan Colcombe, PhDBennett Leventhal, MD

NYU Child Study CenterAdriana DiMartino, MDF. Xavier Castellanos, MDVTCRIStephen LaConte, PhDPearl Chiu, PhDJonathan Lisinski, MS

Emory UniversityHelen Mayberg, MDThis work is funded by: A NARSAD Young Investigator Award and NIMH R01MH101555