use of image registration and fusion algorithms and...
TRANSCRIPT
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Use of Image Registration and
Fusion Algorithms and
Techniques in Radiotherapy
Preliminary Recommendations from TG 132*
Kristy Brock, Sasa Mutic, Todd McNutt, Hua Li, and
Marc Kessler
*Report is currently under review by AAPM
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Disclosure
• Kristy Brock: RaySearch Licensing
• Sasa Mutic: ViewRay Shareholder, Modus
licensing agreement, Varian research and
licensing, Radialogica Shareholder, Treat Safely
Partner
• Todd McNutt: Philips Collaboration, Elekta
Licensing
• Hua Li: Philips Research
• Marc Kessler: Varian research and co-
development agreements
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Learning Objectives
1. Understand the importance of acceptance
testing, including end-to-end tests, phantom
tests, and clinical data tests.
2. Describe the methods for validation and
quality assurance of image registration
techniques.
3. Describe techniques for patient specific
validation.
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Task Group Charge
1. Review the existing techniques and
algorithms for image registration and fusion
2. Discuss issues related to effective clinical
implementation of these techniques and
algorithms in a variety of treatment planning
and delivery situations
3. Discuss the methods to assess the accuracy
of image registration and fusion
4. Discuss issues related to acceptance testing
and quality assurance for image registration
and fusion
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Outline
• Importance of commissioning for image
registration
• Methods for commissioning and clinical
validation
• Example clinical workflow
• Q&A
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Planning IGRT/Dose Accumulation
Adaptation/Retreatment
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Importance of Commissioning
• Implementation effects accuracy1,2
– Cannot infer accuracy based on other studies
• Clinical integration
– Workflow and planning/delivery systems effect
accuracy
• Deformable registration is not ‘always
better’ than rigid
– More degrees of freedom = more potential for
error
1. Kashani, Med Phs, 2008; 2. Brock IJROBP, 2009
Potential Risks of Uncertainties
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Example: Multi-modality imaging for
Planning
Liver: CT (No Contrast = No visible GTV)
Liver: MR (Visible GTV)
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Clinical Registration
X: 26.1mm Y: 119.8mm Z: -12.6mm
X: 1.9deg Y: -2.9deg Z: -4.6deg
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Auto, liver last step
X: 25.6mm Y: 120.8mm Z: -26.1mm
X: -1.5deg Y: 2.5deg Z: -3.4deg
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Nearby Structure Map
X: 14.5mm Y: 122.3mm Z: -26.1mm
X: -1.5deg Y: 2.5deg Z: 4.1deg
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Liver Contour optimization
X: 13.0mm Y: 125.3mm Z: -19.0mm
X: 0.4deg Y: -1.3deg Z: 2.3deg
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Overall Comparison [mm, Degrees] Registration dX dY dZ XROT YROT
ZROT
Overlap
Clinical
26.1 119.8 12.6 1.9 -2.9 -4.6 Defined
Auto
25.6 120.8 -26.1 -1.5 2.5 -3.4
Vessel
14.5 122.3 26.1
-1.5 2.5 4.1
Boundary
13.0 125.3 19.0 0.4 -1.3 2.3
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Example: Dose Accumulation
Exhale 4D CT
Accumulated
Dose
Inhale 4D CT
Planned
Dose Deformable
Registration
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New method to validate Deformable
Image Registration
Control
(No Deformation)
Deformed
(27% Lateral Compression)
Deformable 3D Presage dosimeters
Slides Courtesy of Mark Oldham and Shiva Das
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Dosimeter & Deformable Registration-based Dose
Accumulation: Dose Distributions
Field Displacements Deformed Dosimeter DVF-based
Accumulation
Field Shape Differences
Slides Courtesy of Mark Oldham and Shiva Das
Caution must be used when
accumulating dose, especially in
regions of the image with
homogeneous intensity.
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Validation and QA
How do we Prove it is Reliable?
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Commissioning is Important!
• LINAC
– Know how it works
– Accept and Commission
• Planning System
– Know the dose calculation algorithm
– Accept and Commission
• Deformable Registration Algorithm
– Find out how it works!
– Accept and Commission the software
– Perform an end-to-end test in your clinic
Why is this particularly challenging for deformable
registration?
• Algorithms typically don’t rely on fundamental
physics related to the human anatomy/physiology
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Visual Verification Excellent tool for established techniques
Not enough for Commissioning
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Validation Techniques
• Matching Boundaries
– Does the deformable registration map the
contours to the new image correctly?
• Volume Overlap
– DICE, etc
• Intensity Correlation
– Difference Fusions
– CC, MI, etc
• Digital/Physical Phantoms
• Landmark Based
– TRE, avg error, etc
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Landmark Based
• Reproducibility of point identification is sub-voxel – Gross errors
– Quantification of local accuracy within the target
– Increasing the number increases the overall volume quantification
• Manual technique
• Can identify max errors CT: 512x512x152; 0.09 cm in plane, 0.25 cm
slice; GE scanner; 4D CT with Varian RPM
Error
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Algorithm 1
Algorithm 2
Does Contour Matching Prove Reliability?
Actual Exhale Modeled Exhale
Modeled Exhale Error
102 Bronchial
Bifs
: 3.7 mm
: 2.0 mm
: 8.0 mm
: 3.0 mm
Inhal
e
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Digital or Physical Phantoms • NCAT Phantom
• U of Mich lung phantom
(Kashani, Balter)
• McGill lung phantom
(Serban)
• Can know the true motion of
all points
• Doesn’t include anatomical
noise and variation, likely not
as complex as true
anatomical motion
• Does give a ‘best case’ scenario for
similarity/geometric defm reg
algorithms
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Commissioning and QA Understand the whole picture
Understand
fundamental
components of
algorithm
Phantom
approach to
understand
characteristics of
algorithm
implementation Quantitative
Validation of
Clinical Images Documentation
and Evaluation in
Clinical
Environment
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Validation Tests and Frequencies Frequency Quality Metric Tolerance
Acceptance and
Commissioning
Annual or Upon
Upgrade
System end-to-end tests
Data Transfer (including orientation,
image size, and data integrity)
Using physics phantom
Accurate
Rigid Registration Accuracy (Digital
Phantoms, subset)
Baseline, See details in
Table Z
Deformable Registration Accuracy
(Digital Phantoms, subset)
Baseline, see details in
Table Z
Example patient case verification
((including orientation, image size,
and data integrity)
Using real clinical case
Baseline, see details in
Table Z
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Frequency Quality Metric Tolerance
Each Patient
Data transfer Accurate
Patient orientation Image Data matches specified orientation
(Superior/Inferior, Anterior/Posterior, Left/Right)
Image size Qualitative – no observable distortions, correct aspect
ratio
Data Integrity and Import User defined per TG53 recommendations
Contour propagation Visual confirmation that visible boundaries are within 1-2
voxels of contours; documentation of conformity and
confidence
Rigid registration accuracy At Planning: confirmation that visible, relevant boundaries
are within 1-2 voxels; additional error should feed into
margins
At Tx: confirmation that visible boundaries are within
PTV/PRV margins (doesn’t account for intrafraction
motion)
Deformable registration accuracy At Planning: confirmation that visible, relevant boundaries
and features are within 1-2 voxels; additional error should
feed into margins
At Tx: confirmation that visible boundaries are within
PTV/PRV margins (doesn’t account for intrafraction
motion)
Validation Tests and Frequencies
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Commissioning Datasets*
• Basic geometric phantoms (multi-
modality)1
• Pelvis phantom (CT and MR)1
• Clinical 4D CT Lung2 with simulated
exhale1
*To be made publically available following the approval of TG 132 by AAPM
1. Courtesy of ImSim QA
2. Courtesy of DIR Lab, MD Anderson Cancer Center
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Why Virtual Phantoms
• Known attributes (volumes, offsets,
deformations, etc.)
• Testing standardization – we all are
using the same data
• Geometric phantoms – quantitative
validation
• Anthropomorphic – realistic and
quantitative
Still need end-to-end physical images
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Example Digital Phantoms Provided by the TG-132 via ImSimQA
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Example Digital Phantoms Provided by the TG-132 via ImSimQA
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Example Digital Phantoms Provided by the TG-132
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Example Digital Phantoms Provided by the TG-132
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Recommended Tolerances for the Digital
Phantom Test Cases PHANTOM AND TEST TOLERANCE
Basic geometric phantom registration
Scale – Dataset 1 0.5 * voxel (mm)
Voxel value – Dataset 1 Exact
Registration – Datasets 2, 3, 4, 5, 6 0.5 * voxel (mm)
Contour propagation – Datasets 2, 3, 4, 5, 6 1 * voxel (mm)
Orientation – Datasets 2, 3, 4, 5, 6 Correct
Basic anatomical phantom registration
Orientation - Datasets 1, 3, 4 Correct
Scale - Data sets 1, 3, 4 0.5 * voxel (mm)
Voxel value - Datasets 1, 2, 3, 4, 5 ± 1 nominal value
Registration - Datasets 2, 3, 4, 5 0.5 * voxel (mm)
Contour propagation - Datasets 2, 3, 4, 5 1 * voxel (mm)
Basic deformation phantom registration
Orientation - Dataset 2 Correct
Registration - Dataset 2 95% of voxels within 2 mm, max error less
than 5 mm
Sliding deformation phantom registration
Orientation - Dataset 2 Correct
Scale - Dataset 2 0.5 * voxel (mm)
Registration - Dataset 2 95% of voxels within 2 mm, max error less
than 5 mm
Volume change deformation phantom registration
Orientation - Dataset 2 Correct
Scale - Dataset 2 0.5 * voxel (mm)
Registration - Dataset 2 95% of voxels within 2 mm, max error less
than 5 mm
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Example Clinical Workflow
• Clinic purchased a stand-alone
deformable registration system to
enable MR-CT registration for SBRT
Liver
• Commissioning
• Clinical case validation
• Clinical workflow
• Patient specific QA
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Evaluate Registration Products
• Learn how the different solutions work
• Talk to users
• Evaluate clinical integration and
flexibility
• Purchase
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Commissioning
• Perform end-to-end test with physical
phantom
• Download electronic phantom datasets
from TG 132
– Perform baseline commissioning
• Use ~ 10 retrospective clinical cases to
quantitatively assess accuracy
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Clinical Integration
1. Clear guidelines are provided to the personnel
implementing the image registration and fusion,
2. An efficient, patient specific validation is performed
for each image registration prior to its use (e.g.
qualitative assessment of registration results),
3. Secondary checks or validation are performed at a
frequency to minimize the effect of errors without
prohibiting clinical flow,
4. Clear identification of the accuracy of the
registration are provided to the consumer of the
image fusion so they are fully aware of and can
account for any uncertainties.
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Clinical Integration
• Must consider context of registration
– Timing, Tolerances, Evaluation, etc.
– Systematic vs. random effects
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Request
• Clear identification of the image set(s) to be
registered
– Identification of the primary (e.g. reference)
image geometry
• An understanding of the local region(s) of
importance
• The intended use of the result
– Target delineation
• Techniques to use (deformable or rigid)
• The accuracy required for the final use
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Report
• Identify actual images used
• Indicate the accuracy of registration for local
regions of importance and anatomical
landmarks
– Identify any critical inaccuracies to alert the user
• Verify acceptable tolerances for use
• Techniques used to perform registration
• Fused images in report with annotations
• Documentation from system used for fusion
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Assessment Level Phrase Description
0 Whole scan aligned - Anatomy within 1 mm everywhere
- Useful for structure definition everywhere
- Ok for stereotactic localization
1 Locally aligned - Anatomy local to the area of interest is un-distorted
and aligned within 1mm
- Useful for structure definition within the local region
- Ok for localization provided target is in locally
aligned region
2 Useable with local
anatomical variation
- Aligned locally, with mild anatomical variation
- Useful for reference only during structure definition
on primary image set
- Care should be taken when used for localization
3 Useable with risk of
deformation
- Acceptable registration required deformation which
risks altering anatomy
- Shouldn’t be used for target definition as target
may be deformed
- Useable for dose accumulation
4 Useable for diagnosis
only
- Registration not good enough to rely on geometric
integrity
- Possible use to identify general location of lesion
(e.g PET hot spot)
5 Alignment not acceptable - Unable to align anatomy to acceptable levels
- Patient position variation too great between scans
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TG-132 Product
• Guidelines for understating of clinical
tools
• Digital (virtual) phantoms
• Recommendations for commissioning
and clinical implementation
• Recommendations for periodic and
patient specific QA/QC
• Recommendations for clinical
processes
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Q & A?
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Survey
• Do you use deformable registration in
your clinic?
• Did you perform a formal commissioning
process?
• Do you trust deformable registration for
dose accumulation?