Urinary system

Tutorial

Antibody mediated glomerular disease

B - linear patternC - granular pattern

Causes of the nephrotic syndrome

Proteinuria> 3.5 g of urinary protein:hypoalbuminaemia <3g/dl: oedema, hyperlipidaemia and lipiduria

A – minimal change

B – membranous GN

Membranoproliferative GN

Quiz

A 12 year old boy develops oliguria

Pyelonephritis

Mechanism of renal failure

Type of Stone Frequency

Calcium oxalate (or phosphate) 75%

Magnesium ammonium phosphate(struvite, or "triple phosphate")

12%

Uric acid 6%

Cystine 1%

Other 6%

Renal Stones

RPKD

mutations in chr 6p

DPKD

• Seen in 1 in 500 to 1000 people

• Accounts for 10% of cases of CRF

• Caused by inheritance of 2 AD genes• PKD 1 chr 16 (90% cases) polycystin 1• PKD 2 chr 4 (10% cases) polycystin 2

Hereditary nephritis(Alport’s syndrome)