Zafar Nawaz

CURRICULUM VITAEUpdated June 3, 2005

I. PERSONAL

Name: Zafar Nawaz

Office Phone: 305-243-1456

Current Academic Rank: Associate ProfessorCurrent Track of Appointment: Tenure-Earning TrackPrimary Department: Biochemistry & Molecular Biology

University of Miami School of MedicineJoint Appointment: UM/SCCC Braman Family Breast Cancer

Institute

Citizenship: PakistanVisa Type: Permanent Resident in USA

II: HIGHER EDUCATION:

Institutional:

December 1992- April 1995:Post Doctoral FellowCell Biology, Baylor College of Medicine, Houston, Texas, USA.Area of Research: To unravel the Molecular Mechanism of Action of Nuclear Hormone Receptors with Specific Emphasis on

Estrogen and Progesterone Receptors, Coactivators and Corepressors and to study the role of the ubiquitin-proteasome pathway in steroid hormone receptor functions.

1987- 1992: Ph. D.University of North Texas, Denton, Texas, USA. Thesis: Molecular Mechanism of Action of Steroid Hormone Receptors.

1983- 1985: Master of Science University of Karachi, Pakistan Major- Genetics Minor- Bacterial Genetics

Thesis: Isolation, Characterization and Genetic Studies of Rhizobium Species.

1981- 1983: Bachelor of Science, University of Karachi, Pakistan Major- Biology Minor- Chemistry

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Zafar NawazIII: EXPERIENCE

Academic University of Miami School of Medicine, Department of Biochemistry and Molecular

Biology, Associate Professor, December 1, 2004 - Todate. University of Miami School of Medicine SCCC Braman Family Breast Cancer Institute,

Associate Research Director, December 1, 2004- Todate. University of the Punjab, Lahore, Pakistan. Visiting Professor, 2004-Todate. Creighton University, Omaha, Nebraska, Associate Professor-Department of Surgery,

Medical Microbiology & Immunology and Cancer Center, 2002- 2004. Creighton University, Omaha, Nebraska, Director, Cancer Center Molecular Biology

Core Lab, 2002- 2004. Baylor College of Medicine, Houston, Texas, Assistant Professor-Department of Cell

Biology, 1997- 2002. Baylor College of Medicine, Houston, Texas, Instructor-Department of Cell Biology,

1995- 1997. Baylor College of Medicine, Houston, Texas, Research Associate - Department of Cell

Biology, 1989 – 1995. University of the Punjab, Lahore, Pakistan, Lecturer - Center for Advanced Molecular

Biology, 1986 – 1987. University of the Punjab, Lahore, Pakistan, Research Fellow - Center for Advanced

Molecular Biology, 1985 – 1986.

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Zafar NawazIV. PUBLICATIONS

a. Books and Monographs:

1. N. J. McKenna, Z. Nawaz, S. Y. Tsai, and M.-J. Tsai. Coactivators and corepressors. In Principles of molecular regulation, ed. Conn, P. M. and Means, A. R., Humana press. pp.385-394, 2000.

2. Lonard, D. M., and Z. Nawaz, Coactivators and Corepressors. In Nuclear receptors and genetic disease, ed. Burris, T. P. and McCabe, E., Academic Press Ltd. pp. 389-408, 2000.

3. Z. Nawaz, D. W. Smith and D. P. McDonnell. Expression of functional vitamin D3 receptor in E. coli. In: Vitamin D; Gene Regulation, Structure-Function Analysis and Clinical Application ( A. W. Norman, R. Bouillon and M. Thomasset, eds. ), 1991, pp. 50-51.

4. D. Santiso-Mere, Z. Nawaz, D. P. McDonnell and B. W. O'Malley. The development of Saccharomyces cerevisiae as a host system for steroid hormone action studies: In: Hormone Action and Molecular Endocrinology, 15th edition (M. R. Huges, W. T. Schrader and B. W. O'Malley eds.). Houston biological associates inc., 1991, pp. 23-1- 23-24.

b. Refereed Journal Articles:

1. S. Dhananjayan, O. Y. Khan and Z. Nawaz. Identification and characterization of WW-domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor functions. MCB, 2005. (Under Revision).

2. O. Y. Khan, G. Fu, A. Ismail, S. Srinivasan, Y. Tu, S. Lu and Z. Nawaz. Multifunction steroid receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate gland. Mol. Endocrinology, 2005. (Under Revision).

3. S. Dhananjayan and Z. Nawaz. Ubiquitin and the control of transcription. Assays in Biochem., 2005. (In Press).

3. A. Ismail and Z. Nawaz. Nuclear hormone receptor degradation and gene transcription: An Update. IUBMB Life Sciences, 2005. (In Press).

4. X. Gao, S.K. Mohsin, Z. Gatalica, G. Fu, P. Sharma and Z. Nawaz. E6-associated protein, E6-AP is involved in the carcinogenesis of human breast and prostate. Endocrinology, 2005, 146:1707-1712.

6. S. Verma, A. Ismail, X. Li, B. W. O’Malley and Z. Nawaz. Ubiquitin-Conjugating Enzyme, UBCH7 acts as a coactivator for steroid hormone receptors. MCB., 2004, 24: 8716-8726.

7. Z. Liu, H. Y. Shi, Z. Nawaz and M. Zhang. Tamoxifen induces the expression of maspin through estrogen receptor-alpha. Cancer Lett., 2004, 209: 55-65.

8. Z. Nawaz and B. W. O’Malley. URBAN RENEWAL IN THE NUCLEUS: Is Protein Turnover by Proteasomes Required for Transcription? Mol. Endo., 2004, 18: 493-499.

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Zafar Nawaz

9. O. Y. Khan and Z. Nawaz. Nuclear hormone receptor co-regulators. Current Opinion in Drug Discovery & Development, 2003, 6: 692-701.

10. F. Yan, X. Gao D. Lonard and Z. Nawaz. Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators. Mol. Endo., 2003, 17: 1315-1331.

11. V. Pearce, Z. Nawaz, W. Xiao, D. Wiedenfled, N. Boyle and D. Smith. 4-Ethoxymethylphenol: A novel estrogen that acts as an agonist for human estrogen receptors. Steroid Biochem. And Mol. Biol., 2003, 84: 431-439.

12. X. Gao, B. W. Loggie and Z. Nawaz. The roles of sex steroid receptor coregulators in cancer. Molecular Cancer, 2002, 1: 1-7.

13. X. Gao and Z. Nawaz. Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer. Breast Cancer Res., 2002, 4: 40-44.

14. C. L. Smith, D. G. DeVera, D. J. Lamb, Z. Nawaz, Y. H. Jiang, A. L. Beaudet and B. W. O’Malley. Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Molecular and Cellular Biology, 2002, 22: 525-535.

15. A. P. Dennis, R. Ul Haq, and Z. Nawaz. Importance of the regulation of nuclear receptor degradation. Front. Bioscience, 2001, d954-959.

16. H. Zhao, R. E. Herrera, E. Coronado-Heinsohn, M. C. Yang, J. H. Ludes-Meyers, K. J. Seybold-Tilson, Z. Nawaz, D. Yee, F. G. Barr, S. G. Diab, P. H. Brown, S. A. W. Fuqua, and C. K. Osborne. FKHR, A bifunctional nuclear protein: coactivator and corepressor. J. Biol. Chem., 2001, 276: 27907-27912.

17. L. Sivaraman, Z. Nawaz, D. Medina, O. M. Conneely, and B. W. O’Malley. 2000. The novel dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis. Breast Cancer Research and Treatment, 62: 185-195

18. S. M. Hyder, J. C. Huang, Z. Nawaz, H. B. Tong, S. Makela, C. Chiappetta and G. Stancel. The Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environmental Health Prospectives, 2000, 108 (5), 785-790.

19. J. Li, J. Wang, J. Wang, Z. Nawaz, J. M. Liu, J. Qin, and J. Wong. Both corepressors SMRT and N-CoR proteins exist in large protein complexes containing HDAC3. EMBO, 2000, 19, 4342-4350.

20. D. M. Lonard*, Z. Nawaz*, C. L. Smith, and B. W. O’Malley. The 26S proteasome is required for estrogen receptor- and coactivator turnover and for efficient estrogen receptor- transactivation. Molecualr Cell, 2000, 5, 939-948.*Equal contribution.

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Zafar Nawaz21. S. M. Hyder, Z. Nawaz, C. Chiappetta, and G. Stancel. Detection of classical and atypical estrogen response elements in the untranslated regions of the rat VEGF gene. Cancer Research, 2000, 60, 3183-3190.

22. N. J. McKenna, J. Xu, Z. Nawaz, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. Nuclear receptor coactivator: Multiple enzymes, multiple complexes, multiple functions. J. Steroid Biochem. Mol. Bio., 1999, 69, 3-12.

23. C. E. Robinson, X. Wu, Z. Nawaz, S. A. Onate, and J. M. Gimble. A corepressor and chicken ovalbumin upstream promoter transcription factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter. Endocrinology, 1999, 140, 1586-1593.

24. Z. Nawaz, Lonard, D. M., Dennis, A. P., Smith, C. L., and B. W. O’Malley. Proteasome-dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci. USA, 1999, 96, 1858-1862.

25. Z. Nawaz, G. M. Standcel, and S. M. Hyder. The pure antiestrogen ICI 182780 inhibits progestin-induce transcription. Cancer Res., 1999, 59, 372-376.

26. Z. Nawaz, D. Lonard, C. L. Smith, Efrat Lev-Lehman, Arthur L. Beaudet, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. The angelman syndrome-associated gene, E6-AP, is also a coactivator for nuclear hormone receptor superfamily. Mol. Cell. Bio., 1999, 19, 1182-1189.

27. N. J. McKenna, Z. Nawaz, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. Distinct steady state nuclear receptor coregulator complexes exist in vivo. Proc. Natl. Acad. Sci. USA, 1998, 95, 11697-11702.

28. H. Shibata, Z. Nawaz, S. Y. Tsai, B. W. O’Malley, and M.-J. Tsai. Gene silencing by COUP-TFI is mediated by transcriptional corepressors N-CoR and SMRT. Mol. Endo., 1997, 11, 714-724.

29. C. L. Smith, Z. Nawaz, and B. W. O’Malley. Transcriptional coregulators modulate the relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to activate the estrogen receptor. Mol. Endo., 1997, 11, 657-666.

30. J. Xu, Z. Nawaz, S. Y. Tsai, M. -J. Tsai and B. W. O’Malley. The extreme carboxyl-terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor. Proc. Natl. Acad. Sci. USA., 1996, 93, 12195-12199.

31. Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid receptor ß. Proc. Natl. Acad. Sci. USA., 1995, 92, 11691-11695.

32. T. P. Burris, Z. Nawaz, M. J. Tsai and B. W. O'Malley. Interaction cloning of a protein, TRUP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors. Proc. Natl. Acad. Sci. USA, 1995, 92, 9525-9529.

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Zafar Nawaz33. S. Hyder, Z. Nawaz, C. Chiappetta, K. Yokoyama and G. M. Stancel. Protooncogene c-jun contains an unusual estrogen inducible enhancer within the coding sequences. J. Biol. Chem., 1995, 270, 8506-8513.

34. C. Baniahmad, Z. Nawaz, A. Baniahmad, M. Gleeson, M. J. Tsai and B. W. O'Malley. Enhancement of human estrogen receptor activity by SPT6: A potential Co-activator. Mol. Endo., 1995, 9, 34-43.

35. Z. Nawaz, C. Baniahmad, D. J. Stillman, T. Burris, B. W. O'Malley and M. J. Tsai. The yeast SIN3 gene negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. Mol. General Genetics, 1994, 245, 724-733.

36. S. A. W. Fuqua, D. C. Allred, R. M. Elledge, S. L. Krieg, M. G. Benedix, Z. Nawaz, B. W. O'Malley, G. L. Green and W. L. McGuire. The ER-positive/ PgR-negative breast cancer phenotype is not associated with mutations within the DNA binding domain. Breast Cancer Res. and Treatment, 1993, 26, 191-202.

37. Z. Nawaz, G. M. Stancel, D. P. McDonnell and S. M. Hyder. Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: A possible mechanism for hormonal carcinogenesis? Mol. Carcinogenesis, 1993, 7, 76-82.

38. S. M. Hyder, G. M. Stancel, Z. Nawaz, D. P. McDonnell and D. S. Loose-Mitchell. Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. J. Biol. Chem., 1992, 267, 18047-18054.

39. Z. Nawaz, M. J. Tsai, D. P. McDonnell and B. W. O'Malley. Identification of novel steroid responsive elements. Gene Expression, 1992, 2, 39-47.

40. S. A. W. Fuqua, S. D. Fitzgerald, D. C. Allred, R. M. Elledge, Z. Nawaz, D. P. McDonnell, B. W. O'Malley, G. L. Green and W. L. McGuire. Inhibition of estrogen receptor action by naturally occurring variant in human breast tumors. Cancer Res., 1992, 52, 483-486.

41. D. P. McDonnell, Z. Nawaz and B. W. O'Malley. In situ distinction between steroid receptor binding and transactivation at a target gene. Mol. Cell. Bio., 1991, 11, 4350-4355.

42. D. P. McDonnell, Z. Nawaz, C. Densmore, N. L. Weigal, T. A. Pham, J. H. Clark and B. W. O'Malley. High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae. J. Steroid Biol. and Mol. Biol, 1991, 39, 291-297.

43. T. A. Pham, J. F. Elliston, Z. Nawaz, D. P. McDonnell, M. J. Tsai and B. W. O'Malley. Antiestrogen can established nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc. Natl. Acad. Sci. USA., 1991, 88, 3125-3129.

44. S. A. W. Fuqua, S. D. Fitzgerald, G. C. Chamness, A. K. Tandon, D. P. McDonnell, Z. Nawaz, B. W. O'Malley and W. L. McGuire. Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res., 1991, 51, 105-109.

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45. J. L. Witliff, L. L. Wenz, J. Dong, Z. Nawaz and T. R. Butt. Expression and characterization of an active human estrogen receptor as a ubiquitin fusion protein from Escherichia coli. J. Biol. Chem., 1990, 265, 22016-22022.

46. S. Riazuddin, A. Sohail and Z. Nawaz. Isolation of temperate bacteriophage phi R7 specific for Pseudomonas aeruginosa. Pak. J. of Zool., 1987, 19(3), 290-298.

47. A. Raufa, Z. Nawaz, S. Riazuddin and A. R. Shakoori. Isolation, characterization and genetic studies of Rhizobium meliloti. Pak. J. of Zool., 1987, 19(2), 120-124.

48. M. Neelam, Z. Nawaz and S. Riazuddin. Hydrocarbon Biodegradation: Biochemical characterization of bacteria isolated from local soils. Pak. J. of Sci. and Indus., 1987, Res. 30, 282-285.

49. M. Neelam, Z. Nawaz, A. R. Shakoori and S. Riazuddin. Isolation and characterization of R- factor (plasmids) from antibiotic resistant strains collected from local hospitals. Pak. J. of Zool., 1987, 19(1), 17-26.

50. Z. Nawaz and N. Ahmad. Isolation and characterization of Rhizobium species as nitrogen fixing symbionts in Guar (Cymopsis tetragonoloba (L) Taub). Pak. J. of Zool., 1987, 19(1), 9-15.

51. S. Riazuddin, A. R. Shakoori and Z. Nawaz. Mutagenicity testing of children,s consumables. Pak. J. of Zool., 1986, 18(3), 325- 334.

c. Abstracts:

1. S. Dhananjayan, O. Y. Khan and Z. Nawaz. Identification and characterization of WW-domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor functions. 2005. The Endocrine Society.

2. S. Srinivasan, O. Y. Khan, G. Fu, A. Ismail, Y. Tu, S. Lu and Z. Nawaz. Multifunction steroid receptor coactivator, E6-associated protein, E6-AP is involved in development of the prostate gland. 2005. The Endocrine Society. 3. Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 Modulates Steroid Hormone Receptor Functions. 2nd Ubiquitin Conference. 4. Seema Verma, Ayesha Ismail, Xiatao Li, Bert W. O’Malley and Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.

5. Brian W. Loggie, Nawaz, Z., Zoran Gatalica, Edward Silvaand, and Ghada A El-Ella. 2004. Inhibition of Mucin 2 production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

6. Ghada A El Ella, Zoran Gatalica and Nawaz, Z. 2004. Inhibition of Mucin production:

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Zafar NawazImplications for treatment of breast cancer. AACR Meeting.

7. Shazia Zafar, Xiuhua Gao, Mohsin Khalid, Zoran Gatalica and Nawaz, Z. 2004. E6-associated protein, E6-AP is involved in the carcinogenesis of human breast and prostate. AACR Meeting.

8. Brian W. Loggie, Ghada A El-Ella, Zoran Gatalica, Edward Silvaand and Nawaz, Z. 2003. Promising new strategies for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

9. Nawaz, Z. 2003. Steroid hormone receptor coregulators. Nuclear Receptors as Drug Targets.

10. S. Verma1, X. Li, B. W. O’Malley and Nawaz, Z. 2003. Ubiquitin Conjugating Enzyme, UBCH7 Act As a Coactivator For Steroid Hormone receptors. The Endocrine Society.

11. Nawaz, Z. 2003. Role of Ubiquitin-Proteasome Pathway Enzymes in Steroid Hormone Receptors Transactivation. NIH meeting on Ubiquitin and Ubiquitin like pathways.

12. Riaz Ul Haq and Nawaz, Z. 2002. Identification and characterization of WW-domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine Society.

13. Xiuhua Gao, Syed K. Mohsin, Thomas M. Weeler, Feng Yan and Nawaz, Z. 2002. E6-associated protein, E6-AP, is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine Society.

14. Seema Verma, Zheng Liu, Riaz Haq, Bert W. O’Malley and Nawaz, Z. 2002. UBCH7, an E2 ubiquitin-comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone Symposia.

15. Torsten A. Hopp, Chenguang Wang, Richard G. Pestell, Nawaz, Z., Mingyue Wang, and Suzanne A.W. Fuqua. 2001. A hypersensitive mutation of estrogen receptor a occurring in premalignant breast disease influences co-activator binding, receptor acetylation, and stability. The Endocrine Society.

16. Xiuhua Gao and Nawaz, Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed in human mammary tumors. The Endocrine Society.

17. Torsten Hopp, D. Craig Allred, Sue Hilsenbeck, Syed Mohsin, Nawaz, Z., Peter O’Connell, Richard G. Pestell, and Suzanne A.W. Fuqua. 2000. A Hypersensitive Estrogen Receptor Protein in Breast Cancer. AACR Meeting.

18. .Bert W. O’Malley, Jamin Xu, Nawaz, Z., Ranier Lanz, Niall Barron, Zeng Liu, Brian Rowen, Indreas Cavarretta, Carolyn Smith, Jamieng Wong, Sophia Tsai and Ming Jer Tsai. 2000. In vivo roles of steroid receptor coactivators in gene regulation. The Endocrine Society.

19. Niall Barron, Nawaz, Z., Jun Qin and Bert W. O’Malley. 2000. Effects of the Ccr4/Not complexes on steroid receptor-dependent transcription. The Endocrine Society.

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Zafar Nawaz20. Carolyn Smith, Darryii De Vera, Nawaz, Z., Yong-Hui Jiang, Arthur L. Beaudet and Bert W. O’Malley. 2000. A null mutation of thew steroid receptor coactivator/ubiquitin ligase E6-AP, negatively impact selected tissues of the male and female reproductive tract in mice. . The Endocrine Society.

21. Andrew Dennis, Nawaz, Z. and Bert W. O’Malley. 2000. Characterization of UBA3: A novel type of nuclear hormone receptor coactivator. The Endocrine Society.

22. Nawaz, Z., David M. Lonard, Carolyn L. Smith and Bert W. O’Malley. 2000. Regulation of Gene Expression by the Nuclear Hormone Receptor-Coactivator Complex Requires the Ubiquitin-Proteasome Pathway. The Endocrine Society.

23. Bert W. O’Malley, Jamin Xu, Nawaz, Z., Ranier Lanz, Ray Wu, David M. Leonard, Zeng Liu, Indreas Cavarretta, Carolyn Smith, Jamieng Wong, Sophia Tsai and Ming Jer Tsai. 2000. Roles of steroid receptor co-activators in transcriptional regulation in vitro and in vivo. The Key Stone Symposia.

24. George W. Cox, Nawaz, Z. and Gail V. W. Johnson. 2000. Analysis of a unique nuclear transglutaminase (TGase) substrate expressed in macrophages. American Association of Immunology Meeting.

25. Lonard, D. M., C. L. Smith, Nawaz, Z. and B. W. O’Malley. 2000. Ligand-mediated down-regulation of estrogen receptor-alpha dependes upon intact AF-2 coactivator-binding surfaces, The Key Stone Symposia.

26. Nawaz, Z. and Bert W. O’Malley. 2000. The Nuclear Hormone Receptor Coactivators are Targets of the Ubiquitin-Proteasome Pathway. The Key Stone Symposia.

27. O’Malley, B. W., Lanz, R., Xu, J., Nawaz, Z., Lonard, D., Smith, C. L., Tsai, S. Y., and Tsai, M. J. 1999. Role of steroid receptor coactivators in transcriptional regulation. The Endocrine Society.

28. Hyder, S. Nawaz, Z., and Stancel, G. 1999. A novel antiprogestin activity associated with the pure antiestrogen ICI 182,780: Inhibition of progesterone receptor mediated gene expression. The Endocrine Society.

29. Hyder, S. M., Chiappetta, Nawaz, Z., and Stancel, G. 1999. Detection of two estrogen receptor binding sites located in the 5’ and 3’ untranslated regions of the VEGF gene. The Endocrine Society.

30. H. H. Zhao, E. C. Heinsohn, K. S. Tilson, M. C. Yang, J. H. Ludes-Meyers, Z. Nawaz, R. E. Herrera, D. Yee, P. H. Brown, S. G. Diab, F. G. Barr, B. W. O’Malley, S. W. A. Fuqua and K. Osborne. 1999. FKHR, a bifunctional nuclear receptor intermediary protein, inhibits estrogen-dependent human breast cancer cell growth. The Endocrine Society.

31. Z. Nawaz, Lonard, D. M., Dennis, A. P., Smith, C. L., and B. W. O’Malley 1999. Proteasome-dependent degradation of the human estrogen receptor. The Endocrine Society.

32. H. H. Zhao, E. C. Heinsohn, K. S. Tilson, M. C. Yang, Z. Nawaz, R. E. Herrera, D. Yee, P. H. Brown, S. G. Diab, F. G. Barr, B. W. O’Malley, S. W. A. Fuqua and K. Osborne. 1999.

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Zafar NawazFKHR, a novel nuclear receptor interacting protein that functions as both a coactivator and corepressor. AACR Meeting (The Steroid Receptor Superfamily).

33. D. M. Lonard, Z. Nawaz, C. L. Smith, and B. W. O’Malley. 1999. Involvement of ubiquitin-proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid Receptor Superfamily).

34. S. Hyder, Z. Nawaz, G. M. Stancel. 1999. The pure antiestrogen ICI182,780 exhibits a novel antiprogestin activity and inhibits progesterone receptor dependent gene expression. AACR Annual Meeting.

35. E. L. Lehman, Z. Nawaz, C. Benton, D. Dicks, and A. Beaudet. 1998. Analysis of mutations causing Angelman Syndrome: mRNA stability and UBA3 activity. American Society of Human Genetics.

36. Z. Nawaz, D. Lonard, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley, 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The Endocrine Society.

37. D. Lonard, Z. Nawaz, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. 1998. The ubiquitin-protein ligase E6-AP, mutated in angelman syndrome, is a steroid receptor coactivator. The Key Stone Symposia.

38. Z. Nawaz, D. Lonard, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley, 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The Key Stone Symposia.

39. C. L. Smith, Z. Nawaz, and B. W. O’Malley. 1997. Transcriptional coregulators modulate the relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to activate the estrogen receptor. The Endocrine Society.

40. H. Shibata, Z. Nawaz, S. Y. Tsai, B. W. O’Malley, and M.-J. Tsai. 1997. Gene silencing by COUP-TFI mediated by transcriptional corepressors N-CoR and SMRT. The Endocrine Society.

41. H. Shibata, Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. 1996. Cloning of corepressors for the thyroid hormone receptor with yeast two-hybrid system. The Endocrine Society.

42. Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. 1996. Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia.

43. T. P. Burris, Z. Nawaz, S. Y. Tsai, M. J. Tsai and B. W. O'Malley, 1995. Interaction cloning of a protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors. The Endocrine Society.

44. C. Chiappetta, Z. Nawaz, G. M. Stancel, and S. M. Hyder, 1994. Different nucleotide requirements for estrogen receptor binding and hormone dependent transcriptional activation defines a novel estrogen responsive element within the coding sequence of c-jun. IX International Congress on Hormonal Steroids.

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Zafar Nawaz45. Z. Nawaz, D. Stillman, T. Burris, B. W. O'Malley, and M. J. Tsai, 1994. The yeast SIN3 gene negatively regulates the transcriptional activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society.

46. S. M. Hyder, Z. Nawaz and G. M. Stancel, 1993. A single base change in the flanking sequence of a cellular oncogene creates an active estrogen response element- A possible mechanism of hormonal carcinogenesis? The Endocrine Society.

47. C. Baniahmad, Z. Nawaz, M. J. Tsai and B. W. O'Malley, 1992. Identification and isolation of co-activator for steroid hormone receptors using a yeast host system. Santa Cruiz Summer Conference.

48. S. M. Hyder, D. S. Loose-Mitchell, Z. Nawaz and G. M. Stancel, 1992. A 32 base pair deoxyoligonucleotide derived from murine c-fos protooncogene binds estrogen receptor. The Endocrine Society.

49. S. A. W. Fuqua, D. C. Allred, D. P. McDonnell, Z. Nawaz, B. W. O'Malley, G. L. Green and W. L. McGuire, 1992. A dominant-positive variant estrogen receptor conferes resistance to endocrine therapy in human breast cancer cells. The Endocrine Society.

50. N. Paslidis, C. Baniahmad, Z. Nawaz, D. P. McDonnell, M.-J. Tsai and B. W. O'Malley, 1992. Identification of an 102 KDa protein which interacts with the estrogen receptor in yeast. American Association of Cancer Research.

51. Z. Nawaz, M.-J. Tsai, D. P. McDonnell and B. W. O'Malley, 1992. A system to identify novel steroid response elements. ASBMB/Biophysical Society.

52. S. A. W. Fuqua, D. C. Allred, M. Qui, S. D. Fitzgerald, M. G. Benedix, S. L. Krieg, D. P. McDonnell, Z. Nawaz, B. W. O'Malley, G. Green and W. L. McGuire, 1991. Transcriptionally active estrogen-independent variant estrogen receptors in human breast tumors. Breast Cancer Symposium.

53. Z. Nawaz, D. P. McDonnell and B. W. O'Malley, 1991. A novel system to identify steroid responsive elements. Eight Workshop on Vitamin D.

54. Z. Nawaz, D. W. Smith, D. P. McDonnell and B. W. O'Malley, 1991. Expression of functional vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D.

55. S. A. W. Fuqua, D. C. Allred, R. M. Elledge, G. L. Green, Z. Nawaz and W. L. McGuire. Estrogen receptor mRNA variants in breast cancer. The Endocrine Society.

56. D. P. McDonnell, Z. Nawaz and B. W. O'Malley, 1991. In situ distinction between steroid receptor binding and transactivation at a target gene. The Endocrine Society.

57. C. L. Densmore, D. P. McDonnell, Z. Nawaz and J. H. Clark, 1990. Expression and characterization of human estrogen receptor in yeast Saccharomyces cerevisiae. The Cell Biology Society.

9

Zafar Nawaz

58. S. A. W. Fuqua, D. P. McDonnell, Z. Nawaz, B. W. O'Malley and McGuire, 1990. Variant estrogen receptor RNA transcripts in breast tumors. The Endocrine Society.

59. T. R. Butt, D. P. McDonnell, Z. Nawaz, L. Bowdin, G. Green and D. Drutz, 1989. Human estrogen receptor expression in yeast and its regulation by non-steroidal ligands. Yeast Cell Biology. Cold Spring Harbour.

V: PROFESSIONAL

Funded Research Performed:

a. Active Grants:ACTIVE7R01-DK-056833 (Nawaz, Z) 2/1/00 - 7/31/05 40%

NIH-NIDDK Nuclear Hormone Action: Role of Ubiquitin Pathways

 Role on project: Principal Investigator Direct Cost $602,170 Indirect Cost $297,241 Total amount $ 899,411

7R01-DK-60907 (Nawaz, Z) 9/30/01 - 11/30/05 35% NIH-NIDDKRole of E6-AP in the Development of Prostate Cancer

 Role on project: Principal Investigator Direct Cost $600,000 Indirect Cost $303,000 Total Amount $903,000

2-R01-HL-062400 (Baxter, Timothy) 2/1/05 - 1/31/10 5%

NIH-NHLBIMMP2-Regulation in Aortic AneurysmRole on project: CollaboratorDirect Cost $6,601Indirect Cost $3,400Total Amount $10,001

b. Research Completed:

Department of Defense (Breast Cancer Research Grant, DAMD17-99-9075) 1999-2003 20%Role of nuclear hormone receptor coactivator, E6-associated protein (E6-AP) in the development of breast cancerRole on project: Principal InvestigatorDirect Cost $225,000

10

Zafar Nawaz Indirect Cost $85,800 Total Amount $310,800

Department of Defense (Breast Cancer Research Grant, DAMD17-00-1-0142) 2000-2004 15%Ubiquitin pathway enzymes: Coactivator of nuclear hormone receptors and their role in the development of breast cancer Role on project: Principal InvestigatorDirect Cost $250,575 Indirect Cost $85,800 Total Amount $336,375

Department of Defense (Breast Cancer Research Grant, DAMD17-02-1-0281) 5/13/02-05/12/04 0%Involvement of steroid receptor coactivator/ubiquitin pathway enzymes in mammary gland tumorigenesis.Role on project: MentorDirect Cost $128,703 Indirect Cost $10,297 Total Amount $139,000

NIHNebraska Center for Cellular Signaling 2003-2004 10% Role on project: MentorDirect Cost $11,500 Indirect Cost $4887 Total Amount $16,387

c. PendingM0500836 (Nawaz, Z) 7/1/05 - 6/30/06 15% DODRole of Protein Kinase B (AKT) Yes-Associated Protein (YAP) in Breast CarcinogenesisRole on Project: Principal Investigator Direct Cost $75,000Indirect Cost $38,625Total Amount $113,625

M0500974 (Nawaz, Z) Competitive Renewal 12/1/05-11/30/10 40% NIHNuclear Hormone Action: Role of Ubiquitin Pathways Role on Project: Principal Investigator

Direct Cost $1,250,000 Indirect Cost $643,750 Total Cost $1,893,750

M0501301 (Nawaz, Z) 12/1/05 - 11/30/08 20% DODCharacterization of E6-Associated Protein, E6-AP as a Tumor Suppressor

11

Zafar NawazProteinRole on Project: Principal InvestigatorDirect Cost $300,000Indirect Cost $154,500

Total Amount $454,000

M0501303 (Ramamoorthy, S) 12/1/05 - 11/30/08 0%DODRole of an E-3 Ubiquitin Protein Ligase/Co-Activator in Mammary GlandCarcinogenesisRole on Project: Mentor

 Direct Cost $83,334 Indirect Cost $6,666 Total Amount $90,000

M0501307(Dhananjayan,S) 12/1/05 - 11/30/08 0% DODRole of the PY Motif Containing Protein, WBP-2 in ER, PR Signaling and Breast Tumorigenesis

 Role on Project: Mentor Direct Cost $83,334 Indirect Cost $6,666 Total Amount $90,000

M0501311(Ismail, A) 12/1/05 - 11/30/08 0%DOD Characterization of YAP (Yes Associated Protein) as a Potential Tumor Suppressor Gene in Breast Carcinoma

  Role on Project: Mentor Direct Cost $375,000 Indirect Cost $30,000 Total Amount $405,000

Editorial Responsibilities:

Ad-hoc Reviewer1. Molecular Endocrinology2. Endocrinology3. Cancer Research4. Molecular and Cellular Biology5. Molecular Cell6. PNAS7. Oncology8. Journal of Biological Chemistry9. Science10. J. of Molecular Endocrinology

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Zafar NawazProfessional and Honorary Organizations:The Endocrine SocietyAmerican Society of MicrobiologyThe American Cancer SocietyAmerican Association for the Advancement of SciencePhi Beta Delta Honor SocietyTri Beta Biological Honor SocietyPhi Kapa Phi Honor SocietyHonor Society of International ScholarsWho’s Who

Honors and Awards:

Scholarship awarded by US Academy for Educational Development, 1987-1991.Competitive Botany Research Award, University of North Texas, 1991-1992.Ronald K. Harmon Dissertation Award for Research Achievement in the Applied Life Sciences, University of North Texas, 1992.Davenport/Flaming Award, Texas Medical Center, 1998.Travel Award from Endocrine Society, 1999.Distinguish Alumni Award from University of North Texas, 2000.

Post- Doctoral Fellowship:December 1992- April 1995:Post Doctoral Fellow

Cell Biology, Baylor College of Medicine Area of Research: To unravel the Molecular Mechanism of Action of Nuclear Hormone Receptors with Specific Emphasis onEstrogen and Progesterone Receptors, Coactivators and Corepressors and to study the role of the ubiquitin-proteasome pathway in steroid hormone receptor functions

Other Professional Activities:

a. Poster presentations:

1. Z. Nawaz, D. W. Smith, D. P. McDonnell and B. W. O'Malley, 1991. Expression of functional vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D, Paris, France.

2. Z. Nawaz, D. P. McDonnell and B. W. O'Malley, 1991. A novel system to identify steroid responsive elements. Eight Workshop on Vitamin D, Paris, France.

3. Z. Nawaz, M.-J. Tsai, D. P. McDonnell and B. W. O'Malley, 1992. A system to identify novel steroid response elements. ASBMB/Biophysical Society, USA.

4. S. M. Hyder, Z. Nawaz and G. M. Stancel, 1993. A single base change in the flanking sequence of a cellular oncogene creates an active estrogen response element- A possible mechanism of hormonal carcinogenesis? The Endocrine Society, USA.

5. Z. Nawaz, D. Stillman, T. Burris, B. W. O'Malley, and M. J. Tsai, 1994. The yeast SIN3 gene negatively regulates the transcriptional activity of the human progesterone receptor and

13

Zafar Nawazpositively regulates the activities of GAL4 and the HAP1 activator. The Endocrine Society, USA.

6. T. P. Burris, Z. Nawaz, S. Y. Tsai, M. J. Tsai and B. W. O'Malley, 1995. Interaction cloning of a protein, TRIP, which inhibits transactivation by the thyroid hormone and retinoic acid receptors. The Endocrine Society, USA.

7. Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. 1996. Specific mutations in the ligand binding domain selectively abolish the silencing function of human thyroid receptor ß. The Key Stone Symposia, USA.

8. Z. Nawaz, D. Lonard, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley, 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The Key Stone Symposia.

9. D. Lonard, Z. Nawaz, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. 1998. The ubiquitin-protein ligase E6-AP, mutated in Angelman syndrome, is a steroid receptor coactivator. The Key Stone Symposia.

10. D. M. Lonard, Z. Nawaz, C. L. Smith, and B. W. O’Malley. 1999. Involvement of ubiquitin-proteasome mediated protein degradation in steroid receptor function. AACR Meeting (The Steroid Receptor Superfamily).

11. H. H. Zhao, E. C. Heinsohn, K. S. Tilson, M. C. Yang, Z. Nawaz, R. E. Herrera, D. Yee, P. H. Brown, S. G. Diab, F. G. Barr, B. W. O’Malley, S. W. A. Fuqua and K. Osborne. 1999. FKHR, a novel nuclear receptor interacting protein that functions as both a coactivator and corepresso. AACR Meeting (The Steroid Receptor Superfamily).12 . Lonard, D. M., C. L. Smith, Nawaz, Z. and B. W. O’Malley. 2000. Ligand-mediated down-regulation of estrogen receptor-alpha dependes upon intact AF-2 coactivator-binding surfaces, The Key Stone Symposia.

13. George W. Cox, Nawaz, Z. and Gail V. W. Johnson. 2000. Analysis of a unique nuclear transglutaminase (TGase) substrate expressed in macrophages. American Association of Immunology Meeting.

14. Andrew Dennis, Nawaz, Z. and Bert W. O’Malley. 2000. Characterization of UBA3: A novel type of nuclear hormone receptor coactivator. The Endocrine Society.

15. Niall Barron, Nawaz, Z., Jun Qin and Bert W. O’Malley. 2000. Effects of the Ccr4/Not complexes on steroid receptor-dependent transcription. The Endocrine Society.

16. Torsten Hopp, D. Craig Allred, Sue Hilsenbeck, Syed Mohsin, Nawaz, Z., Peter O’Connell, Richard G. Pestell, and Suzanne A.W. Fuqua. 2000. A Hypersensitive Estrogen Receptor Protein in Breast Cancer. AACR Meeting.

17. Xiuhua Gao and Nawaz, Z., 2001. The nuclear hormone receptor coactivator, E6-AP is overexpressed in human mammary tumors. The Endocrine Society.

18. Torsten A. Hopp, Chenguang Wang, Richard G. Pestell, Nawaz, Z., Mingyue Wang, and Suzanne A.W. Fuqua. 2001. A hypersensitive mutation of estrogen receptor a occurring in

14

Zafar Nawazpremalignant breast disease influences co-activator binding, receptor acetylation, and stability. The Endocrine Society.

19. Seema Verma, Zheng Liu, Riaz Haq, Bert W. O’Malley and Nawaz, Z. 2002. UBCH7, an E2 ubiquitin-comjugating enzyme: Its possible role in the steroid receptor transactivation. The Key Stone Symposia.

20. Xiuhua Gao, Syed K. Mohsin, Thomas M. Weeler, Feng Yan and Nawaz, Z. 2002. E6-associated protein, E6-AP, is involved in the tumorigenesis of both mammary gland and prostate gland. The Endocrine Society.21. Riaz Ul Haq and Nawaz, Z. 2002. Identification and characterization of WW-domain binding proteins as E6-AP interacting proteins and their role in steroid hormone receptor functions. The Endocrine Society.

22. Brian W. Loggie, Ghada A El-Ella, Zoran Gatalica, Edward Silvaand and Nawaz, Z. 2003. Promising new strategies for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

23. Shazia Zafar, Xiuhua Gao, Mohsin Khalid, Zoran Gatalica and Z. Nawaz. 2003. E6-associated protein, E6-AP is involved in the carcinogenesis of human breast and prostate. AACR Meeting.

24. Ghada A El Ella, Zoran Gatalica and Z. Nawaz. 2003. Inhibition of Mucin production: Implications for treatment of breast cancer. AACR Meeting.

25. Brian W. Loggie, Nawaz, Z., Zoran Gatalica, Edward Silvaand, and Ghada A El-Ella. 2003. Inhibition of Mucin 2 production: Implications for treatment of Pseudomyxoma Peritonei. The Surgical Society of Oncology.

26. Shazia Zafar, Xiuhua Gao, Mohsin Khalid, Zoran Gatalica and Nawaz, Z. 2004. E6-associated protein, E6-AP is involved in the carcinogenesis of human breast and prostate. AACR Meeting.

27. Seema Verma, Ayesha Ismail, Xiatao Li, Bert W. O’Malley and Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with SRC-1 and E6-AP. Key Stone Symposia on Nuclear hormone receptors.

b. Invited Oral Presentations:

Z. Nawaz, 1993. Cloning of steroid hormone receptors in yeast (Saccharomyces cerevisiae). University of North Texas, Denton, Texas, USA.

Z. Nawaz, 1994. The yeast SIN3 gene negatively regulates the transcriptional activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator. Proc. 76th Ann Mtg Endocrine Soc., Anaheim, California, USA.

Z. Nawaz, 1995. Molecular mechanism of action of steroid hormone receptors. University of North Texas, Denton, Texas, USA.

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Zafar NawazZ. Nawaz, 1995. Molecular mechanism of gene silencing by thyroid hormone receptor. Baylor College of Medicine, Houston, Texas, USA.

Z. Nawaz, 1996. Mechanism of gene silencing by thyroid hormone receptor. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.

Z. Nawaz, 1997. A novel host system to study steroid hormone receptor action. National Institute of Biotechnology and Genetic Engineering, Faisalabad, Pakistan.

Z. Nawaz, 1997. A novel host system to study steroid hormone receptor action. Nuclear Institute of Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan

Z. Nawaz, 1997. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. Baylor College of Medicine, Houston, Texas, USA.

Z. Nawaz, 1998. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. The Endocrine Society Meeting, New Orleans.

Z. Nawaz, 1998. The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. University of Oklahoma Health Science Center.

Z. Nawaz, 1999. Proteasome-dependent degradation of the human estrogen receptor. The Endocrine Society Meeting, San Diego.

Z. Nawaz, 1999. Impact of the ubiquitin-proteasome pathway on nuclear hormone action. Tumor Biology Section, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA

Z. Nawaz, 2000. The Angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone receptor superfamily. University of North Texas, Denton, Texas.

Zafar Nawaz, 2000. Regulation of Gene Expression by the Nuclear Hormone Receptor-Coactivator Complex Requires the Ubiquitin-Proteasome Pathway. The Endocrine Society.

Zafar Nawaz, 2002. E6-Associated Protein (E6-AP) and Steroid Hormone Receptor Functions. Department of Pharmacology and Cell Biophysics. University of Cincinnati Medical School. Cincinnati, Ohio.

Zafar Nawaz, 2002. Steroid hormone receptor coregulators. Department of Pharmacology. Texas Tech University, Amarillo, Texas.

Zafar Nawaz, 2002. Steroid hormone receptor cactivators. Cancer Center, Creighton University, Omaha, Nebraska.

Zafar Nawaz, 2003. Steroid hormone receptor cactivators and gene transcription. Center for Advanced Molecular Biology. Lahore, Pakistan.

Zafar Nawaz, 2003. Novel coactivators of steroid hormone receotprs. IBC meeting on Nuclear Receptors as Targets for Drug Development, Philidelphia, USA.

Zafar Nawaz, 2003. Role of the ubiquitin-proteasome pathway in nuclear hormone receptor functions. NIH. USA.

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Zafar Nawaz

Zafar Nawaz, 2003. Ubiquitin Conjugating Enzyme, UBCH7 a coactivator for steroid hormone receptors. Endocrine Meeting. Philidelphia, USA.

Zafar Nawaz, 2003. Novel modulators of steroid hormone receptors. Biomedical Sciences. Creighton University, Omaha, Nebraska, USA.

Zafar Nawaz, 2004. Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by forming a multiprotein complex with SRC-1 and E6-AP, MD Anderson, Houston, Texas, USA.

Zafar Nawaz, 2004. Ubiquitin-Proteasome Pathway Enzymes act as Modulators of Steroid Hormone Receptors. Cancer Center, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

c. Patents Applied:

1. Use of “Pure” Antiestrogen Synthetic Steroids to Inhibit Progestin-Induced Transcription and Method for Administrating Same to Humans and Animals; No. 60/090,074; G&S No. 25630/04

2. Novel Coactivator Overexpressed in Endocrine Tumors; OTA# 98-83; P-017503. Production of antibodies against a novel coactivator, E6-associated protein (E6-AP).4. siRNAs mediated reduction of expression of mucin proteins in neoplasms.5.Development of New Therapeutic Agents for the Treatment of Breast Cancer.

d. Courses and Workshops Attended:

Thirteenth Annual Molecular Endocrine Workshop, USAEight Workshop on Vitamin D, Paris, FranceThe ASBMB/Biophysical Society Workshop, USA The Forty-sixth Annual Symposium on Fundamental Cancer Research, USAThe Welch Foundation Conference on Chemical research, USAThe Endocrine Society Annual Meeting, USAThe Key Stone Symposium, USA

e. Study Sections:

1. Department of Veterans Affairs2. US Army Prostate Cancer Research Program3. US Army Breast Cancer Research Program4. NIH 5. Texas A&M University, Center for Environmental and Rural Health, Pilot Project Grant

Application

VI: TEACHING

Teaching Awards Reserved:

None

Teaching Specialization:

17

Zafar Nawaz

I recently moved from Creighton University to University of Miami School of Medicine. Before moving to Creighton University, I served as a faculty at Baylor College of Medicine. At Creighton University I was involved in 2 training grants: 1) Nebraska Center for Cellular Signaling and 2) Molecular Dissection of Age-Related Diseases. I was acting as a mentor for junior faculty on these grants. Additionally, I was also acting as a Co-PI on the grant entitled “Molecular Dissection of Age-Related Diseases”. I have also been invited to act as a mentor on the K01 proposals of Dr. Beth Floyd, Louisiana State University System and Dr. Prema Rampuri, Creighton University.

I am also involved in both postdoctoral training and graduate student training. Currently, I am training two postdoctoral fellows and three graduate students. At Baylor College of Medicine I organized a weakly seminar series for postdoctoral fellows and graduate students. I was also acting as a course director for the graduate courses entitled “Seminar in Cell & Molecular Biology (242-466)” and “Readings (242-548)”. At Creighton University, I was involved in graduate course entitled “Cell Signaling”.

I have serve as a member on the thesis committees of several graduate students. Member of thesis Advisory Committee at the University of North Texas, Denton, Texas. Member of thesis Advisory Committee at Department of Cell Biology, Baylor College of

Medicine, Houston, Texas.

Pre-Doctoral Student Supervision:

CURRENT GRADUATE STUDENTS

Sarath Dhananjayan (2002-)Sivapriya Ramamoorthy (2003-)Sathishkumar Srinivasan (2004-)

CURRENT POSTDOCTORAL FELLOWS

Ayesha Ismail (2003-)Guilian Fu (2003-)

Names of Mentor

and Traineesa

(include training level

Training Period(Site as

applicable b)

Degree(s) Prior to Entering Training

Title of Research

ProjectWhile Training

With This Mentor

Type(s) AwardDate(s)

AwardingInstitution

Zafar Nawaz

Sarath Dhananjayan (pre)

2003-present

M.S. 8/01 Bharathidasam University

Role of WBP-2 in Steroid hormone receptor function and

18

Zafar Nawaz

Sivapriya Ramamoorthy (pre)

Andrew Dennis (pre)

Virginia Pearce (pre)

Sathish Srinivasan (pre)

Ayesha Ismail (post)

Guilian Fu (post)

Xiuhual Gao (post)

2004-present

1999-2004

1997-2002

2004-present

2003-present

2003-present

1999-2004

M.S.

Ph.D.

Ph.D.

M.S.

Ph.D.

M.D.

Ph.D.

8/01

12/04

06/97

8/01

12/99

8/80

9/93

Bharathidasam University

Baylor College of Medicine

University of North Texas

Birla Institute of Technology and Science

National Institute of Nutrition, India.

Julin Medical College

Torai University,

breast carcinogenesis

Role of E6-AP in mammary gland development and Breast carcinogenesis

Function of protein degradation by 26S peoteasome during progesterone receptor dependent transcription

Isolation and characterization of new phytoestrogen(s) that modulate human estrogen receptor activity.

Role of E6-AP in prostrate gland development and carcinogenesis

Role of the ubiquitin-proteasome pathway in breast carcinogenesis

Role of E6-AP in prostrate gland development and carcinogenesis

19

Zafar Nawaz

Obaid Y. Khan (post)

Seema Verma (post)

Minawar Sattar (post)

Riaz-ul-Haq (post)

2002-2004

2001-2003

2001-2002

2000-2002

Ph.D.

Ph.D.

PhD

PhD

5/98

2000

12/00

1996

Japan

University of Glasgow

University of Punjab

Texas A&M

University of Punjab

Role of E6-AP in breast carcinogenesis

Role of E6-AP in prostate gland development

Characterization of UbcH7 as a coactivator for steroid hormone receptors

Role of E6-AP in the development of normal prostate gland and prostate gland cancer

Role of the ubiquitin-proteasome pathway in nuclear hormone receptor function

VII: SERVICE:

Committees and Administrative Responsibilities:

Associate Research Director of the Braman Family Breast Cancer Institute/ SCCC, Miami, Florida, 2004-Todate.

Member of the Advisory Board of the Cancer Center of Creighton University, 2002-2004.

Member of Creighton University’s Research Organizing Committee, Omaha, Nebraska, 2002- 2004.

Director for Molecular Biology Laboratory at Creighton University, Omaha, Nebraska, 2002- 2004.

Director of Yeast Biology Laboratory at Baylor College of Medicine, Houston, Texas, 1997- 2002.

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