unravelling the biological characteristics of mammaprint ... · normalized enrichmet score ul gsea...

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70-gene MP 22 UH -log 10(adj.P.Val) log 2 FLC UH vs. HR log 2 FLC UL vs. LR -log 10(adj.P.Val) Activating Invasion & metastasis Deregulating cellular energetics Enabling replicative immortality Evading growth suppressors Genome instability and mutation Immune response 70-gene MP UL 546 Department of Research and Development, Agendia, Amsterdam, the Netherlands; Contact: [email protected] Hallmarks of Cancer Unravelling the biological characteristics of MammaPrint extreme risk subgroups

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Page 1: Unravelling the biological characteristics of MammaPrint ... · normalized enrichmet score ul gsea g2m checkpoint 11.6 jak stat3 signaling p13k akt mtor signaling inflammatory response

70-gene MP

22

UH

-lo

g 1

0(a

dj.

P.V

al)

log2FLC

UH vs. HR

log2FLC

UL vs. LR

-lo

g 1

0(a

dj.

P.V

al)

Activating Invasion & metastasis

Deregulating cellular energetics

Enabling replicative immortality

Evading growth suppressors

Genome instability and mutation

Immune response

70-gene MP UL

546

Department of Research and Development, Agendia, Amsterdam, the Netherlands;

Contact: [email protected]

Hallmarks of Cancer

Unravelling the biological characteristics of MammaPrint extreme risk subgroups

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René Bernards MammaPrint, the story of the 70-gene profile Professor of Molecular Carcinogenesis The Netherlands Cancer Institute Amsterdam Chief Scientific

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Oncotype Dx Mammaprint

Les signatures génomiques sont prédictives : …senologie.tv/pdfs_up/5a096fc51ba23.pdfSIGNATURES GÉNOMIQUES ONCOTYPE DX Genomic Health Inc. MAMMAPRINT Agendia Inc. PROSIGNA Nanostring

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Edinburgh Research Explorer · wide scan for layers from the second outbreak, pathway analysis revealed P13K/AKT signaling as the most signiﬁcant pathway. In summary, resistance

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Adjuvant! Online ! Online - NKIresearch.nki.nl/amaros/Symposium 2009/Adjuvant Online.pdf · 2009. 11. 13. · Adjuvant Adjuvant & MammaPrint MammaPrint (70-genen profiel) • Pooled

MammaPrint - JCCNB2009/10/18 · MammaPrint The current situation and future developments Laura J. van ‘t Veer Netherlands Cancer Institute, Amsterdam Agendia Inc, The Netherlands

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