University of Windsor

Department of Chemistry and Biochemistry

Chemistry: Centre for Catalysis and Materials Research

Biochemistry & Biotechnology Research

University of WindsorDepartment of

Chemistry and Biochemistry

+ 2

Welcome to Chemistry & Biochemistryat the University of Windsor

What is Chemistry?

Programs: Chemistry, Biochemistry & Biotechnology

What Are Our Programs and Courses Like?

About the Department

Scholarship Opportunities

Undergraduate Research Opportunities

Faculty Profiles

What can you do with a degree in Chemistry?

Chemistry: The Central Science

Biology Chemistry Physics

Biochemistry

Synthesizers Characterizers

Organic Chemistry

Inorganic Chemistry

Physical Chemistry

Analytical Chemistry

Biotechnology

What Programs are Available?ChemistryMost general of the degrees, trains student in a broad variety of chemistry sub-disciplines

BiochemistryEmphasis upon chemistry of living systems

Biochemistry & BiotechnologySimilar to biochemistry, with slightly different course focus

Chemistry & PhysicsPhysics and physical chemistry focus

Spectroscopy

What are the programs like?

Chemistry Physics Math Biology Options

Organic Inorganic Physical

Analytical

First Year (Chemistry or Biochemistry)

Second Year

Third Year

Biomolecules

Instrumental Analysis

Quantum Mechanics

Organometallic

Materials Science

Biochemistry Program

Fourth Year

Polymers

Organic Spectroscopy

Advanced Topics

Computational

NMR Spectroscopy

Advanced Topics

Photochemistry

IntermediateOrganic

Biochemistry is the study of the chemistry of living systems, including organic biomolecules, proteins, DNA, nucleic acids and enzymes.

Biotechnology is a set of powerful tools that employ living organisms (or parts of organisms) to make or modify products, improve plants or animals, or develop microorganisms for specific uses.

Courses in Biochemistry & Biotechnology:

Organic Chemistry of Biomolecules Metabolism

Proteins and Nucleic Acids Enzymology

Biotechnology Lab Course DNA Science

Membrane Biochemistry RNA Chemistry

Biochemistry & Biotechnology

Our department…Our department places emphasis on teaching and research – our students are exposed to junior and senior level courses taught by some of the top scientists in Canada.

In Chemistry, 2004:#6 in Canada for overall funding from NSERC#5 in Canada for funding per faculty member (20 funded faculty!)#1 in Canada for research funding in Inorganic Chemistry

From 2000 – 2005, over 12 million dollars in renovations of research laboratories and purchase of scientific instruments makes our department one of the best equipped in Canada, and comparable (or better) than top U.S. institutions!

Professors supervise graduate and undergraduate students in world-class research projects in a variety of areas.

Departmental FacilitiesRenovated Synthetic Laboratories (2000-2005)

X-ray Crystallography

Nuclear Magnetic Resonance

Surface Enhanced Raman Imaging

Undergraduate LaboratoriesIn Fall 2005, all laboratory renovations are complete, with new fumehoods, elephant trunks, lab benches & safety equipment!

Newly revised laboratories and new lab equipment provides students with the chance to obtain sound laboratory skills and technical experience with modern analytical instrumentation.

Science Resource CentreThe new Science Resource Centre in Essex Hall opened in January 2004.

The resource centre is staffed by graduate teaching assistants who help students in 1st and 2nd year courses. Computers are available for scientific computing, calculations and word processing!

Undergraduate ResearchStudents are given the opportunity to work in world class, state-of-the-art research facilities

Summer research project students funded by NSERC or CCMR

Honours project in Chemistry or Biochemistry (59-410)

Lab technicians, part time work in research laboratories

Earn money & gain experience with work study

The opportunity to participate in an active research environment helps many students with future career choices and provides them with practical experience desired by academia, government laboratories and industry

Scholarships & Awards

Students with good academic track records can receive/apply for a variety of awards:- Outstanding Scholars (Chemistry, Chem & Phys)

- 1st Year Entrance Scholarships ($1000)

- 2nd Year Book Prizes

- Summer NSERC Research Scholarships ($6000)

- Centre for Catalysis & Materials Research (CCMR) Undergraduate Research Scholarships ($5500)

- Peter Wyzinski Memorial Award (3rd year: Chemistry, $500)

- Canadian Society for Chemistry Prizes (4th year: Chemistry, Biochemistry)

- Society for Chemical Industry Award (4th year: Chemistry, Biochemistry)

- Hutnik Research Award (Best research project, Biochemistry, $500)

- Dennis Tuck Memorial Award (Best research project, Chemistry, $500)

A Good Community to Work In24 faculty in Chem & Biochem,including 11 new members

Accessible faculty for teaching and research opportunities

Friendly, stimulating & productive environment to work in

Materials Chemistry

Chemists: Bridging the Disciplines

Organic Inorganic Physical Analytical

James Green

Charles Macdonald

Inorganic

Doug Stephan

Steve Loeb

Dave Antonelli

Rob Schurko

Organic Chemistry

Main Group Chemistry

Organometallics & Catalysis

Supramolecular Chemistry

Mesoporous Solids

Solid State NMR

Phil Dutton Physical Organic

Ricardo ArocaVibrational & Raman Spectroscopy

Holger Eichhorn Organic Materials & Liquid Crystals

Jichang WangNon-linear Chemical Dynamics

Sam Johnson Transition Metal Chemistry

Avinash Thadani Organic Chemistry

Tricia Carmichael Materials Chemistry

Organic Chemistry

Chemistry of compounds containing carbon and hydrogen (C, H, O, N, P and S) - building blocks of life

Picture of some reaction mechanism

Prof. James GreenProf. Phil DuttonProf. Holger EichornProf. Avinash Thadani

James GreenAssociate Professor, University of Windsor, 1990NSERC Postdoctoral Fellow, U. of California at BerkeleyPh.D. 1987, University of Waterloo B.Sc. 1982, University of Windsor

Organic Synthesis with Transition Metal Units

SiEt3Bu3Sn

EtO OEt

Co2(CO)6Co2(CO)6

5 equiv BF3-OEt2, CH2Cl2, 0

oC

Formation of Seven- Membered Cyclic Alkyne Complexes

72%

Phil DuttonAssistant Professor, University of Windsor, 1991Post-Doctoral Fellow, NRC Canada, 1989B.Sc. 1985, Ph.D. 1988, University of Victoria

Physical Organic Chemistry

+

Mn+

Mn+

Mn+ Mn+

Ionophores can be attached to surfaces in a variety of manners.Langmuir-Blodgett films are lifted from layers of molecules floating on water surfaces.Self Assembled Monolayers are formed from solutions onto surfaces.Applications are in Sensor Technology

– the binding event causes a response

Holger EichhornAssistant Professor, University of Windsor, 2001Postdoctoral Fellow, Massachusetts Institute of Technology, 1999Postdoctoral Research Assistant, University of Leeds, SOMS, England, 1997Postdoctoral Fellow, University of Exeter, England, 1996Diploma in Chemistry (1991), Ph.D.,(1995) Postdoctoral Fellow (1996),University of Bremen, Germany

Mesomorphism – gateway to new materials for nanotechnology materials with defined supramolecular or nano-structured architectures that are

persistent and uniform on macroscopic length scales

S

S

S

S

SS S

S

S

SS-Ac

S

S

S

S

S

S

S S

O

S-Ac

OO

OC18H37

S SSS S

SS

S

S

S

S

SS S

S

S

S

S

S

S

S

S

S

S

O

S

O O

OR

O

S

OO

OR

S S

O

S

OO

OR

O

S

O O

OR

S

2 nm diameter metal colloid

COO- M+

+

+

2 nm diameter metal colloid

M+ -OOC COO-M+M+ -OOC

3

4

self-organization

R = C18H37

charged head-group thiol

tail-group thiol

NanoParticle-AmphiphilesPhotovoltaic device containing astar-shaped hetero-heptamer

Avinash ThadaniAssistant Professor, University of Windsor, 2004Post-doctoral fellow, University of Chicago, 2001-2004Ph.D. (Toronto) – 2001B.Sc. (Toronto) – 1996

Asymmetric Catalysis & Natural Product Synthesis

(a) Development of Novel Chiral Ligands and Application in C–C Bond Forming Reactions(b) Synthesis of Bioactive Alkaloids

Bioactive AlkaloidsChiral Ligands

N

O

O

H

N

O

O

H

R

R = H, securinineR = OMe, phyllanthine

(–)-norsecurinine

N N

R

R

R

R

:

B(OH)2 Br

Ar

Pd2(dba)3 (cat.)A (cat.)

Cs2CO3 (2 equiv.)dioxane, ²

Ar

A

Inorganic Chemistry

The chemistry of all the elements except carbon*

f – block (lanthanides and actinides)

p – block(main group)

d – block (transition metals)

s – block(main group)

* (Organic Chemistry)

Prof. Doug StephanProf. Stephen LoebProf. David AntonelliProf. Charles MacdonaldProf. Samuel JohnsonProf. Tricia Carmichael

Doug StephanDepartment HeadProfessor, NSERC/NOVA Chemicals Industrial Research ChairOrganometallic Chemistry: Catalyst discovery and developmentNATO Postdoctoral Fellow (Harvard University 1980-1982)B.Sc. (McMaster, 1976), Ph.D. (UWO, 1980)

A + B C + D

Ea

Ea

Reactants

Products

• catalyst provides an alternative, low activation energy pathway for a reaction in which a is the catalyst is regenerated

• not consumed in the reaction

Organometallic Chemistry & Catalysis

Stephen LoebProfessor and Canada Research ChairRoyal Society of Chemistry, Visiting Professor, Oxford UniversityAssistant Professor, University of Winnipeg Post-Doctoral Fellow, University of AlbertaB.Sc (Hon), Ph.D. University of Western Ontario

Supramolecular Chemistry & Molecular MachinesInterpenetrated Molecules

+

“thread” or “axle”

“bead” or “wheel”

[2]-Pseudorotaxane

Interlocked Molecules

“Stopper”[2]-Rotaxane

+ 2

David AntonelliAssociate Professor, University of Windsor, 1998Lecturer 1997 University of SussexResearch Associate 1994-1996 - MITResearch Associate 1994 University of AlbertaNSERC, Postdoc 1991-1993 Oxford/CaltechPhD - 1990 University of Alberta

Mesoporous Metal Oxide Materials

Synthesis and characterization of composite materials

Assistant Professor, University of Windsor, 2001Postdoctoral Fellow, University of Texas, 1998Ph.D., Dalhousie, 1998B.Sc. (Hons.) Dalhousie, 1994

Main Group Inorganic Chemistry

Sam JohnsonAssistant Professor, University of Windsor, 2002NSERC PDF, U. of California at Berkeley, 2000Ph.D. 2000, University of British ColumbiaB.Sc. 1995, McMaster University

PHOTONICS: NONLINEAR OPTICS LIGAND DESIGN

LnM R

LnM N

N R

N2 ?

N2 ACTIVATION

Organometallics and Materials

Tricia CarmichaelAssociate Professor, University of Windsor, 2005Research Staff Member, IBM T.J. Watson Research CenterNSERC PDF – Harvard UniversityPh.D. 1996, University of WindsorB.Sc. 1992, University of Windsor

Surface & Materials Chemistry: Microelectronics

Indium Tin Oxide film patterned using microcontact printing and wet etching

Patterned Ni film fabricated using micro-contact printing & electrodeless plating

Physical/Analytical ChemistryPhysical Chemistry: Measuring physical properties of materials, determining molecular structureAnalytical Chemistry: Determining the constituents and contents of mixtures, solids, liquids, etc.

Prof. Ricardo ArocaProf. Rob SchurkoProf. Jichang Wang

FINGERPRINTS - SPECTROSCOPY

University Professor, University of WindsorD. Sc., Supreme Attestation Commission of the Soviet UnionPhD in Chemistry, Moscow State University, 1970B.Sc. University of Chile, 1964Born Chile in 1943

Rob SchurkoAssistant Professor, University of Windsor, 2000Postdoc, University of Illinois at Chicago, 1999Postdoc, State University of New York at Stony Brook, Brookhaven Nat’l Lab, 1998Ph.D. Dalhousie University, 1998B.Sc. (Hons), M.Sc. University of Manitoba, 1992, 1994

Solid-State Nuclear Magnetic Resonance (NMR)

40000 20000 0 -20000 -40000 Hz

ExperimentalTimes:

40 minutes

340 minutesConventional 91ZrSpin-Echo NMR

91Zr QCPMG NMR

- NMR of quadrupolar (spin > 1/2) nuclei to characterize structure and dynamics in inorganic & organometallic materials

- Sensitivity enhancement for exotic NMR nuclei

Assistant Professor, University of Windsor, 2002Postdoctoral Fellow, Lethbridge University, 2000Postdoctoral Fellow, West Virginia University, 1996Postdoctoral Fellow, ETH Zurich, Switzerland, 1995Ph.D. Copenhagen University, Denmark, 1994B.Sc. Tsinghua University, P. R. China, 1991

Dynamics and Mechanism of Oscillating Chemical Reactions

An example of manipulating chemical reactions with light, in which oscillatory phenomena are induced by light in the otherwise non-oscillatory medium

Jichang Wang

BiochemistryBiochemistry: The chemistry of living systems, including biomolecules, proteins, DNA, RNA, etc.

Prof. Sirinart Ananvoranich – RNA biochemistryProf. James Gauld – Computational biochemistryProf. Lana Lee – Protein Structure & FunctionProf. Bulent Mutus – Biochemistry of NOProf. Sirayam Pandey – Cell DeathProf. Keith Taylor – Applied EnzymologyProf. Otis Vacratsis – Mass Spectrometry

Assistant Professor, University of Windsor, 2000Ph.D. Concordia University (1995)B.Sc, M.Sc (Pharm), Chulalongkorn, Thailand, 1989

Delta ribozyme and its applications.

• Catalytic ribonucleic acids “Delta ribozyme”.

• Delta ribozyme can be modified to cut other ribonucleic acids (RNA) and could be a therapeutic agent, a gene-based drug.

• We are using delta ribozyme as anti-parasitic drugs in our laboratory.

Delta ribozyme

Sirinart Ananvoranich

Assistant Professor, 2001Post-doctoral fellow, Dalhousie University, Halifax, Canada (1999-2001)Post-doctoral fellow, Uppsala University, Uppsala, Sweden (1997-1999) B.Sc., Ph.D. Australian National University (1997)

Computational Chemistry &Molecular Modeling of Biochemical Systems

James Gauld

Associate ProfessorPh.D. University of Alberta, Biochemistry, 1980 A.B. Mount Holyoke College, Chemistry 1973

• Nuclear Magnetic Resonance

• Blood Coagulation• Detoxification• Bacterial Systems

(E.coli & volcanic)• Drug Design

Cys-12

C

N

NMR structure ofArsenate Reductase

Lana Lee

Protein Structure and Function

ProfessorPh.D. University of Manitoba (1982)B.Sc./M.Sc. University of Waterloo

Nitric oxide mediated communication between cells:

• vasodilation

N=O produced in endothelial cells (blood vessel walls) causes muscle cells to relax

Bulent Mutus

Assistant Professor, University of Windsor, 2000JNU, New Delhi, Ph.D. 1992BHU, Varanasi, M.Sc. 1986

Human Neurons Cancer Cells

Apoptosis (cell death) is involved in:

Cancer, AIDS, Alzheimer’s Disease, Parkinson’s Disease and Stroke

Study of the biochemical mechanism of cell death in these diseases.

Programmed Cell Death and Aging Research Lab

Sirayam Pandey

Applied Enzymology• Analytical biochemistry, environmental biotechnology, bio-

organic chemistry, (glyco)protein chemistry, enzyme immobilization

• Business applications with devices and processes• Main current application: enzyme-based industrial wastewater

treatment Remediation but not degradation Possible to capture organic material for re-cycling Enabled by enzymes as commodities (fermentation or plant,

eg. Soybeans, products) Fast, cheap, simple and “green”

ProfessorPh.D. University of Toronto (1976)

Keith Taylor

Proteomics

200 400 600 800m/z

0

100NHNH22-EACDPLR-COOH-EACDPLR-COOH

MS/MS

Biomarkers

Biological Mass

SpectrometryPosttranslational

Modifications

Assistant ProfessorPh.D. Michigan State University (2001)Post doctoral fellowship University of Michigan

Otis Vacratsis

Careers in Chemistry

Chemistry/Biochemistry

Laboratory Technicians and Research Associates-Analytical Chemists-Organic Chemists-Biochemists-Biotechnologists & Molecular Biologists-Pharmacy, Food and Agriculture, Plastics and Coatings, Drug Testing, Environmental, etc.

Specialized Chemistry-Forensic Science-Blood Chemistry-Molecular Spectroscopy-Environmental Chemistry

Research and Development-Industrial Positions-Government Laboratories-Academic Institutions

Chemical Education-Professors-Teachers-Laboratory Instructors-Safety and disposal

Professionals- Chemistry and Health- Patent Attorneys- Environmental Assessment- Pre-professional (i.e., medicine, dentistry, veterinary medicine, pharmacy, etc.)

Chemical Industry ($$$!)- Synthesis and evaluation/testing- Manufacturing QA/QC- Safety control and risk assessment- Research and Development - Biotechnology

Salaries & Employment for Chemists

B.Sc.

Industry $60.0 Government $58.2 Academia $45.0

Four years to complete

All Chemists$80,000

Final Degree ObtainedB.Sc. $59.7M.Sc. $71.3Ph.D. $90.0

Employment SectorIndustry $86.0Government $77.0Academia $63.0

M.Sc.

Industry $76.5 Government $65.8 Academia $52.1

Two years after B.Sc.

Ph.D.

Industry $98.0 Government $91.0 Academia $65.4

Four years after B.Sc.

Data source: All data from Chemical & Engineering News, as of March 1, 2003Annual median salaries given in thousands of dollars (U.S.) for full time chemists employed as of March 1, 2003

Chemist salaries grow faster than cost of living: 4.9 % increase 1996-2001Employment situation: 92.1% employment as of 2003, steady <3.5% unemp.Women as chemists: Education 41.4%, General 34.6%, Biochemistry 30.4%, Analytical 23%

Important folks that you should remember

Department Head:Dr. Doug Stephan

59-140 Chemistry Professors:Dr. David Antonelli, Dr. David Tramontozzi

First year lab coordinator:Mrs. Tina Lepine

Chemistry Office Staff:Ms. Beth KickhamMrs. Brenda Schreiber, Mrs. Marlene Bezaire

Chemical Control Centre:Mr. Chris BuschMr. Jerry Vriesacker, Mr. Bill Middleton

What sets Chemistry & Biochemistry at the University of Windsor apart from the others

1. High teacher to student ratios not found in larger institutions mean that professors are accessible to students - you will find both professors and their graduate students very approachable

2. Most faculty have government and/or industrial funding to run active research programs in a wide variety of sub-disciplines

3. Eleven new faculty have been hired in the past five years - a variety of new research and teaching areas have opened up at Windsor, and the curriculum is continually being revamped to make our students competitive in the academic and industrial sectors

4. Windsor provides a small university environment for a top research-oriented department - excellent contact with major industrial partners and larger academic institutions (e.g., Wayne State, University of Michigan, etc.), and correspondingly, many advantages for our students

5. We have research instrumentation and new laboratories that match or beat much larger institutions in Canada or the United States

Chemistry & Biochemistryat the University of Windsor

For more information:Chemistry and BiochemistryUniversity of Windsor401 Sunset AvenueWindsor, OntarioCanada N9B 3P4

Phone:(519) 253-3000 ext:3521FAX:(519)-973-7098 Email:chembio@uwindsor.caWebsite:www.uwindsor.ca/chemistry

COMPREHENSIVE

Ranking   Last year

1 Guelph 3

2 Waterloo 1

3 Simon Fraser 2

4 Victoria 4

5 Memorial 5

*6 Regina 7

*6 York 6

8 New Brunswick 10

9 Carleton 8

10 Concordia 11

11 Windsor 9

MEDICAL/DOCTORAL

Ranking   Last year

1 Toronto 1

2 Queen’s 3

*3 McGill 4

*3 Western 6

5 UBC 2

6 Montréal 7

7 Alberta 5

8 Sherbrooke 14

9 Ottawa 10

10 McMaster 8

11 Dalhousie 9

12 Saskatchewan 11

13 Laval 12*

14 Calgary 12*

15 Manitoba 15

*indicates a tie

 

UNDERGRADUATE

Ranking   Last year

1 St. Francis Xavier 2

2 Mount Allison 1

3 Acadia 4

4 Winnipeg 5

5 Wilfrid Laurier 7

 *6 Bishop’s 6

 *6 Trent 3

8 UNBC 14

9 UPEI 15

10 St. Thomas 10

11 Saint Mary’s 9

12 Mount Saint Vincent 16

13 Lethbridge 8

14 Brock 12

15 Moncton 11

16 Ryerson 19

Macleans University Rankings

Faults with the Macleans Methodology

STUDENT BODY (21% to 22% of final score)- incoming students' average high-school grades (11%)- proportion of those with averages of 75 per cent or higher (3%)- out-of-province students in the first-year undergraduate class (1.5%)

REPUTATION (20%) - Reputational survey (15%):- Maclean's sent surveys to 7,528 individuals across the country. Respondents rated the universities in three categories: Highest Quality, Most Innovative and Leaders of Tomorrow. Best Overall represents the sum of the scores. -Alumni Support, institutions received points for the number -- rather than the value -- of gifts to the university over the past five years (5%) – Windsor does well here

When respondents were asked to rank the 25 categories in important, REPUTATION sub-categories actually wound up near the bottom of the list (20 – 23)

Macleans makes a straight ranking – no comparison of how similar the schools are to one another

1 McGill University 3 M/D

2 University of Toronto 1 M/D

3 University of British Columbia 5 M/D

4 McMaster University 10 M/D

5 University of Alberta 7 M/D

6 York University 6 Comp

7 Carleton University 9 Comp

8 Simon Fraser University 3 Comp

15 University of Windsor 11 Comp

16 University of Western Ontario 3 M/D

17 University of Winnipeg 4 Undergrad

20 Queens’ University 2 M/D

21 University of Waterloo 2 Comp

24 Dalhousie University 11 M/D

25 University of Guelph 1 Comp

U.S. Rankings: The Gourman Report

Gourman Report Methodology

No “points” for reputation or average entering grades340 US and 50 Canadian schools over 7 yearsRankings in many more categories, plus numerical results as opposed to simple rating system

- Institutional auspices, control and organization - Number of education programs and degrees conferred - Experience level (age) of an institution - Faculty quality, experience, intellectual pursuits and research productivity - Quality of students' scholastic works and records of graduates in postgraduate studies and in their field of practice. - Number of students enrolled - Curriculum content - Quality of instruction and teaching loads - Quality of administration - Quality and access to career placement services and counseling - Quality of physical plant (buildings, surroundings) - Finance, budgets, investments, expenditures and funding - Quality of library (size, material relevance and access) - Computing facilities and resources - Athletic-academic balance - Funding for research equipment and infrastructure - Number of teaching and research opportunities

• For students majoring in Chemistry, Physics, Earth Sciences and Mathematics.

• May be held in addition to other scholarships.

80-84.9 $10,000 ($1000 x 4 years) TA/RA ($2000 x 3 years)

85-89.9 $12,000 ($1500 x 4 years) TA/RA ($2000 x 3 years)

90-94.9 $14,000 ($2000 x 4 years) TA/RA ($2000 x 3 years)

95-100 $16,000 ($2500 x 4 years) TA/RA ($2000 x 3 years)

Outstanding Scholars Awards